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Conserved domains on  [gi|442626998|ref|NP_995663|]
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uncharacterized protein Dmel_CG3748, isoform C [Drosophila melanogaster]

Protein Classification

LEM domain-containing protein( domain architecture ID 10650460)

LEM domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LEM smart00540
in nuclear membrane-associated proteins; LEM, domain in nuclear membrane-associated proteins, ...
14-57 3.86e-14

in nuclear membrane-associated proteins; LEM, domain in nuclear membrane-associated proteins, including lamino-associated polypeptide 2 and emerin.


:

Pssm-ID: 128813  Cd Length: 44  Bit Score: 66.20  E-value: 3.86e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442626998    14 QDIQRLTDAQLSTMCKSHGLILGPITFQNRRMAERKLHIAMITE 57
Cdd:smart00540   1 DDVDRLSDAELRAELKQYGLPPGPITDTTRKLYEKKLRKLRRGG 44
 
Name Accession Description Interval E-value
LEM smart00540
in nuclear membrane-associated proteins; LEM, domain in nuclear membrane-associated proteins, ...
14-57 3.86e-14

in nuclear membrane-associated proteins; LEM, domain in nuclear membrane-associated proteins, including lamino-associated polypeptide 2 and emerin.


Pssm-ID: 128813  Cd Length: 44  Bit Score: 66.20  E-value: 3.86e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442626998    14 QDIQRLTDAQLSTMCKSHGLILGPITFQNRRMAERKLHIAMITE 57
Cdd:smart00540   1 DDVDRLSDAELRAELKQYGLPPGPITDTTRKLYEKKLRKLRRGG 44
LEM cd12934
LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner ...
19-55 1.38e-03

LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins; The family corresponds to a group of inner nuclear membrane proteins containing LEM domain. Emerin occurs in four phosphorylated forms and plays a role in cell cycle-dependent events. It is absent from the inner nuclear membrane in most patients with X-linked muscular dystrophy. Emerin interacts with A-type and B-type lamins. Man1, also termed LEM domain-containing protein 3 (LEMD3) is an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization. LAP2, also termed thymopoietin (TP), or thymopoietin-related peptide (TPRP), is composed of isoform alpha and isoforms beta/gamma and may be involved in chromatin organization and post-mitotic reassembly. Some LAP2 isoforms are inner nuclear membrane proteins that can bind to nuclear lamins and chromatin, while others are non-membrane nuclear polypeptides. This family also contains LEM domain-containing protein LEMP-1 and LEM2. LEMP-1, also termed cancer/testis antigen 50 (CT50), is encoded by LEMD1, a novel testis-specific gene expressed in colorectal cancers. LEMP-1 may function as a cancer-testis antigen for immunotherapy of colorectal carcinoma (CRC). LEM2, also termed LEMD2, is a novel Man1-related ubiquitously expressed inner nuclear membrane protein required for normal nuclear envelope morphology. Association with lamin A is required for its proper nuclear envelope localization while its binding to lamin C plays an important role in the organization of lamin A/C complexes. Some uncharacterized LEM domain-containing proteins are also included in this family. Unlike other family members, these harbor an ankyrin repeat region that may mediate protein-protein interactions.


Pssm-ID: 240585  Cd Length: 37  Bit Score: 36.23  E-value: 1.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 442626998  19 LTDAQLSTMCKSHGLILGPITFQNRRMAERKLHIAMI 55
Cdd:cd12934    1 LSDDELRRELKELGEPPGPITDTTRKVYLKKLAKLLK 37
LEM pfam03020
LEM domain; The LEM domain is 50 residues long and is composed of two parallel alpha helices. ...
15-50 4.05e-03

LEM domain; The LEM domain is 50 residues long and is composed of two parallel alpha helices. This domain is found in inner nuclear membrane proteins. It is called the LEM domain after LAP2, Emerin and Man1.


Pssm-ID: 460781  Cd Length: 40  Bit Score: 34.77  E-value: 4.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442626998   15 DIQRLTDAQLSTMCKSHGLILGPITFQNRRMAERKL 50
Cdd:pfam03020   1 DVDQLSDEELREQLKEYGVSPGPITATTRKLYEKKL 36
 
Name Accession Description Interval E-value
LEM smart00540
in nuclear membrane-associated proteins; LEM, domain in nuclear membrane-associated proteins, ...
14-57 3.86e-14

in nuclear membrane-associated proteins; LEM, domain in nuclear membrane-associated proteins, including lamino-associated polypeptide 2 and emerin.


Pssm-ID: 128813  Cd Length: 44  Bit Score: 66.20  E-value: 3.86e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442626998    14 QDIQRLTDAQLSTMCKSHGLILGPITFQNRRMAERKLHIAMITE 57
Cdd:smart00540   1 DDVDRLSDAELRAELKQYGLPPGPITDTTRKLYEKKLRKLRRGG 44
LEM cd12934
LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner ...
19-55 1.38e-03

LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins; The family corresponds to a group of inner nuclear membrane proteins containing LEM domain. Emerin occurs in four phosphorylated forms and plays a role in cell cycle-dependent events. It is absent from the inner nuclear membrane in most patients with X-linked muscular dystrophy. Emerin interacts with A-type and B-type lamins. Man1, also termed LEM domain-containing protein 3 (LEMD3) is an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization. LAP2, also termed thymopoietin (TP), or thymopoietin-related peptide (TPRP), is composed of isoform alpha and isoforms beta/gamma and may be involved in chromatin organization and post-mitotic reassembly. Some LAP2 isoforms are inner nuclear membrane proteins that can bind to nuclear lamins and chromatin, while others are non-membrane nuclear polypeptides. This family also contains LEM domain-containing protein LEMP-1 and LEM2. LEMP-1, also termed cancer/testis antigen 50 (CT50), is encoded by LEMD1, a novel testis-specific gene expressed in colorectal cancers. LEMP-1 may function as a cancer-testis antigen for immunotherapy of colorectal carcinoma (CRC). LEM2, also termed LEMD2, is a novel Man1-related ubiquitously expressed inner nuclear membrane protein required for normal nuclear envelope morphology. Association with lamin A is required for its proper nuclear envelope localization while its binding to lamin C plays an important role in the organization of lamin A/C complexes. Some uncharacterized LEM domain-containing proteins are also included in this family. Unlike other family members, these harbor an ankyrin repeat region that may mediate protein-protein interactions.


Pssm-ID: 240585  Cd Length: 37  Bit Score: 36.23  E-value: 1.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 442626998  19 LTDAQLSTMCKSHGLILGPITFQNRRMAERKLHIAMI 55
Cdd:cd12934    1 LSDDELRRELKELGEPPGPITDTTRKVYLKKLAKLLK 37
LEM pfam03020
LEM domain; The LEM domain is 50 residues long and is composed of two parallel alpha helices. ...
15-50 4.05e-03

LEM domain; The LEM domain is 50 residues long and is composed of two parallel alpha helices. This domain is found in inner nuclear membrane proteins. It is called the LEM domain after LAP2, Emerin and Man1.


Pssm-ID: 460781  Cd Length: 40  Bit Score: 34.77  E-value: 4.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442626998   15 DIQRLTDAQLSTMCKSHGLILGPITFQNRRMAERKL 50
Cdd:pfam03020   1 DVDQLSDEELREQLKEYGVSPGPITATTRKLYEKKL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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