Vitellinogen, open beta-sheet; This entry represents the open beta-sheet domain found in ...
665-1005
1.86e-84
Vitellinogen, open beta-sheet; This entry represents the open beta-sheet domain found in vitellinogen, which generally corresponds to a domain within the lipovitellin-1 peptide product. This domain adopts a structure consisting of several large open beta-sheets.
:
Pssm-ID: 462702 Cd Length: 300 Bit Score: 280.38 E-value: 1.86e-84
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
3741-3908
1.33e-14
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.
The actual alignment was detected with superfamily member smart00216:
Pssm-ID: 214566 [Multi-domain] Cd Length: 163 Bit Score: 74.36 E-value: 1.33e-14
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
3952-4014
4.57e-03
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.
:
Pssm-ID: 214843 Cd Length: 76 Bit Score: 38.86 E-value: 4.57e-03
Vitellinogen, open beta-sheet; This entry represents the open beta-sheet domain found in ...
665-1005
1.86e-84
Vitellinogen, open beta-sheet; This entry represents the open beta-sheet domain found in vitellinogen, which generally corresponds to a domain within the lipovitellin-1 peptide product. This domain adopts a structure consisting of several large open beta-sheets.
Pssm-ID: 462702 Cd Length: 300 Bit Score: 280.38 E-value: 1.86e-84
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal ...
50-632
3.08e-55
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport. This family contains the LV1n chain from lipovitellin, that contains two structural domains.
Pssm-ID: 460170 [Multi-domain] Cd Length: 582 Bit Score: 205.20 E-value: 3.08e-55
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
3741-3908
1.33e-14
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.
Pssm-ID: 214566 [Multi-domain] Cd Length: 163 Bit Score: 74.36 E-value: 1.33e-14
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
3751-3909
3.01e-10
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.
Pssm-ID: 459671 [Multi-domain] Cd Length: 154 Bit Score: 61.62 E-value: 3.01e-10
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
3952-4014
4.57e-03
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.
Pssm-ID: 214843 Cd Length: 76 Bit Score: 38.86 E-value: 4.57e-03
Vitellinogen, open beta-sheet; This entry represents the open beta-sheet domain found in ...
665-1005
1.86e-84
Vitellinogen, open beta-sheet; This entry represents the open beta-sheet domain found in vitellinogen, which generally corresponds to a domain within the lipovitellin-1 peptide product. This domain adopts a structure consisting of several large open beta-sheets.
Pssm-ID: 462702 Cd Length: 300 Bit Score: 280.38 E-value: 1.86e-84
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal ...
50-632
3.08e-55
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport. This family contains the LV1n chain from lipovitellin, that contains two structural domains.
Pssm-ID: 460170 [Multi-domain] Cd Length: 582 Bit Score: 205.20 E-value: 3.08e-55
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
3741-3908
1.33e-14
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.
Pssm-ID: 214566 [Multi-domain] Cd Length: 163 Bit Score: 74.36 E-value: 1.33e-14
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
3751-3909
3.01e-10
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.
Pssm-ID: 459671 [Multi-domain] Cd Length: 154 Bit Score: 61.62 E-value: 3.01e-10
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
3952-4014
4.57e-03
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.
Pssm-ID: 214843 Cd Length: 76 Bit Score: 38.86 E-value: 4.57e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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