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Conserved domains on  [gi|665400030|ref|NP_995796|]
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nidogen, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
322-549 3.79e-98

G2 nidogen domain and fibulin;


:

Pssm-ID: 214774  Cd Length: 227  Bit Score: 313.23  E-value: 3.79e-98
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    322 ANDQPIRVTGTLTGELNKQ--PVS-EEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANG 398
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGefPVAfENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNG 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    399 YQLTGGVYTHVSRLQFDSGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGelksvqVLN 478
Cdd:smart00682   81 FQLTGGVFTRETEVTFAGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPG------VLT 154

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665400030    479 INITEEQRV----LGLQVEQRILYRSCLRDDEADPSatKVLQKISKVALDYVERDQALRIGAMSKVGVTPESNAC 549
Cdd:smart00682  155 TSSTREYTVdnqtHSYTVDQTITFEECQHRDAFPPT--TQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQC 227
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
108-262 1.99e-48

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 169.53  E-value: 1.99e-48
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    108 FYSNVDTsfsdEGTSISLF-ESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYFDSKTDR-LNTFQVALIANE 185
Cdd:smart00539    2 FWADADT----EGTGKVYYrETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDgTNTFQAVLATDG 77

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400030    186 QSTFVQFIYPDGGLNWLQGETAGLGlpdIRAQAGFVAEDGRF-YTLNGSGSENARFLSESTNLGVPGVWLFEVAPIEN 262
Cdd:smart00539   78 SRTYAIFLYPSLGWTSDTTAGGDDG---VRARAGFNGGDGTFsYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1152-1195 9.15e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 9.15e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 665400030   1152 VIINKQLVNPRGIAVDPYREKLFWSDWDResPKIEMSNLDGTGR 1195
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1107-1145 1.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.99e-10
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 665400030   1107 RPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLD 1145
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA pfam07645
Calcium-binding EGF domain;
591-622 4.01e-10

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.09  E-value: 4.01e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665400030   591 DIDECATGSHVCDENAVCDNTEGGFNCYCTEG 622
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1001-1036 7.11e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 7.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030  1001 CLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLC 1036
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 836-873 3.69e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 3.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665400030   836 CAIRPDICDVHADCVYEEhlGKSECQCQAGYTGNGFNC 873
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTG--GSFTCTCNDGYTGDGVTC 36
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1074-1254 1.06e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14956:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 274  Bit Score: 45.74  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1074 AIGLDKDcveGRVYWGDISTKKIVSTKYDGTDLRPFITT-----DIESPEGIAIDvISRRLYWADSAKDTIEVASLDDpS 1148
Cdd:cd14956    17 GIAVDAD---DNVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLTG-E 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1149 LRAVIINK-----QLVNPRGIAVDPyREKLFWSDW--DRespkieMSNLDGTGRELLLGKDDVTLPNSL-----VVLENS 1216
Cdd:cd14956    92 LQTIGGSSgsgpgQFNAPRGVAVDA-DGNLYVADFgnQR------IQKFDPDGSFLRQWGGTGIEPGSFnyprgVAVDPD 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 665400030 1217 GEVCYADAGTKKVECIEPQNRQIRTISN------ELSYPFGITF 1254
Cdd:cd14956   165 GTLYVADTYNDRIQVFDNDGAFLRKWGGrgtgpgQFNYPYGIAI 208
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 963-995 1.11e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665400030   963 NNCGIHATCEPTEDpaNYECQCIAGFKGDGYVC 995
Cdd:pfam12947    6 GGCHPNATCTNTGG--SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 285-320 1.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.27  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030   285 CQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSC 320
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 797-828 1.82e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 1.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665400030   797 NCHINATCNWYGQelRHICTCQPGFRGDGYNC 828
Cdd:pfam12947    7 GCHPNATCTNTGG--SFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
322-549 3.79e-98

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 313.23  E-value: 3.79e-98
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    322 ANDQPIRVTGTLTGELNKQ--PVS-EEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANG 398
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGefPVAfENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNG 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    399 YQLTGGVYTHVSRLQFDSGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGelksvqVLN 478
Cdd:smart00682   81 FQLTGGVFTRETEVTFAGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPG------VLT 154

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665400030    479 INITEEQRV----LGLQVEQRILYRSCLRDDEADPSatKVLQKISKVALDYVERDQALRIGAMSKVGVTPESNAC 549
Cdd:smart00682  155 TSSTREYTVdnqtHSYTVDQTITFEECQHRDAFPPT--TQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQC 227
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 324-543 3.66e-77

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 254.54  E-value: 3.66e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030  324 DQPIRVTGTLTGELNKQPVSEE---AKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQ 400
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQSPVEfgdADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNGFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030  401 LTGGVYTHVSRLQFDS-GENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGELKSVQVLNI 479
Cdd:cd00255    81 LTGGEFTRQAEVTFYTgGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVLTSSSTREY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665400030  480 NITE--EQRVLGLQVEQRILYRSCLRDDEADPSATKVlqKISKVALDYVERDQALRIGAMSKVGVT 543
Cdd:cd00255   161 TVDEggESQTLSYQWNQTITYEECPHDDEAAPDLQQL--LVARIFALYNPEEEILRFAITNSIGPG 224
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 324-505 2.73e-63

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 213.22  E-value: 2.73e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030   324 DQPIRVTGTLTGELNKQPVsEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTG 403
Cdd:pfam07474    1 GVPQRVNGKVSGTINGVEF-GDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFSLTG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030   404 GVYTHVSRLQFD-SGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGELKSVQVLNINIT 482
Cdd:pfam07474   80 GVFNRTAEVTFPpTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGELTSSSTRTYTVD 159

                          170       180
                   ....*....|....*....|....*
gi 665400030   483 EEQ--RVLGLQVEQRILYRSCLRDD 505
Cdd:pfam07474  160 GEGntRTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
108-262 1.99e-48

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 169.53  E-value: 1.99e-48
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    108 FYSNVDTsfsdEGTSISLF-ESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYFDSKTDR-LNTFQVALIANE 185
Cdd:smart00539    2 FWADADT----EGTGKVYYrETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDgTNTFQAVLATDG 77

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400030    186 QSTFVQFIYPDGGLNWLQGETAGLGlpdIRAQAGFVAEDGRF-YTLNGSGSENARFLSESTNLGVPGVWLFEVAPIEN 262
Cdd:smart00539   78 SRTYAIFLYPSLGWTSDTTAGGDDG---VRARAGFNGGDGTFsYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 174-257 7.38e-31

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 116.62  E-value: 7.38e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030   174 LNTFQVALIANEQSTFVQFIYPDGGLNWLQGETAGL--GLPDIRAQAGFVAED--GRFYTLNGSGSENARFLSESTNLGV 249
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGtnGLGGTPAQAGFSAGDgdGRYYELPGSGTDSIRNLTETSNVGV 80


                   ....*...
gi 665400030   250 PGVWLFEV 257
Cdd:pfam06119   81 PGRWVFRI 88
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1152-1195 9.15e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 9.15e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 665400030   1152 VIINKQLVNPRGIAVDPYREKLFWSDWDResPKIEMSNLDGTGR 1195
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1107-1145 1.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.99e-10
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 665400030   1107 RPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLD 1145
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA pfam07645
Calcium-binding EGF domain;
591-622 4.01e-10

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.09  E-value: 4.01e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665400030   591 DIDECATGSHVCDENAVCDNTEGGFNCYCTEG 622
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-625 5.38e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 5.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665400030  591 DIDECATGsHVCDENAVCDNTEGGFNCYCTEGFEG 625
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1001-1036 7.11e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 7.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030  1001 CLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLC 1036
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
591-630 7.69e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 7.69e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 665400030    591 DIDECATGsHVCDENAVCDNTEGGFNCYCTEGFEgNGYRC 630
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 836-873 3.69e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 3.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665400030   836 CAIRPDICDVHADCVYEEhlGKSECQCQAGYTGNGFNC 873
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTG--GSFTCTCNDGYTGDGVTC 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1074-1254 1.06e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.74  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1074 AIGLDKDcveGRVYWGDISTKKIVSTKYDGTDLRPFITT-----DIESPEGIAIDvISRRLYWADSAKDTIEVASLDDpS 1148
Cdd:cd14956    17 GIAVDAD---DNVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLTG-E 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1149 LRAVIINK-----QLVNPRGIAVDPyREKLFWSDW--DRespkieMSNLDGTGRELLLGKDDVTLPNSL-----VVLENS 1216
Cdd:cd14956    92 LQTIGGSSgsgpgQFNAPRGVAVDA-DGNLYVADFgnQR------IQKFDPDGSFLRQWGGTGIEPGSFnyprgVAVDPD 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 665400030 1217 GEVCYADAGTKKVECIEPQNRQIRTISN------ELSYPFGITF 1254
Cdd:cd14956   165 GTLYVADTYNDRIQVFDNDGAFLRKWGGrgtgpgQFNYPYGIAI 208
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 963-995 1.11e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665400030   963 NNCGIHATCEPTEDpaNYECQCIAGFKGDGYVC 995
Cdd:pfam12947    6 GGCHPNATCTNTGG--SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 285-320 1.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.27  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030   285 CQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSC 320
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1084-1179 1.71e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1084 GRVYWGDISTKKIVSTKYDGTDlrpfittdiesPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIinKQLVNPRG 1163
Cdd:COG3391    90 GRVSVIDLATGKVVATIPVGGG-----------PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI--PVGAGPHG 156

                          90
                  ....*....|....*.
gi 665400030 1164 IAVDPYREKLFWSDWD 1179
Cdd:COG3391   157 IAVDPDGKRLYVANSG 172
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 797-828 1.82e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 1.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665400030   797 NCHINATCNWYGQelRHICTCQPGFRGDGYNC 828
Cdd:pfam12947    7 GCHPNATCTNTGG--SFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1084-1123 2.40e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 2.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665400030  1084 GRVYWGDISTK-KIVSTKYDGTDLRPFITTDIESPEGIAID 1123
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1171-1212 2.68e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 2.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665400030  1171 EKLFWSDWdRESPKIEMSNLDGTGRELLLgKDDVTLPNSLVV 1212
Cdd:pfam00058    1 GRLYWTDS-SLRASISSADLNGSDRKTLF-TDDLQHPNAIAV 40
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1076-1105 5.80e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 5.80e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 665400030   1076 GLDKDCVEGRVYWGDISTKKIVSTKYDGTD 1105
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
 
Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
322-549 3.79e-98

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 313.23  E-value: 3.79e-98
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    322 ANDQPIRVTGTLTGELNKQ--PVS-EEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANG 398
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGefPVAfENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNG 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    399 YQLTGGVYTHVSRLQFDSGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGelksvqVLN 478
Cdd:smart00682   81 FQLTGGVFTRETEVTFAGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPG------VLT 154

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665400030    479 INITEEQRV----LGLQVEQRILYRSCLRDDEADPSatKVLQKISKVALDYVERDQALRIGAMSKVGVTPESNAC 549
Cdd:smart00682  155 TSSTREYTVdnqtHSYTVDQTITFEECQHRDAFPPT--TQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQC 227
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 324-543 3.66e-77

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 254.54  E-value: 3.66e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030  324 DQPIRVTGTLTGELNKQPVSEE---AKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQ 400
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQSPVEfgdADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNGFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030  401 LTGGVYTHVSRLQFDS-GENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGELKSVQVLNI 479
Cdd:cd00255    81 LTGGEFTRQAEVTFYTgGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVLTSSSTREY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665400030  480 NITE--EQRVLGLQVEQRILYRSCLRDDEADPSATKVlqKISKVALDYVERDQALRIGAMSKVGVT 543
Cdd:cd00255   161 TVDEggESQTLSYQWNQTITYEECPHDDEAAPDLQQL--LVARIFALYNPEEEILRFAITNSIGPG 224
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 324-505 2.73e-63

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 213.22  E-value: 2.73e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030   324 DQPIRVTGTLTGELNKQPVsEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTG 403
Cdd:pfam07474    1 GVPQRVNGKVSGTINGVEF-GDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFSLTG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030   404 GVYTHVSRLQFD-SGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGELKSVQVLNINIT 482
Cdd:pfam07474   80 GVFNRTAEVTFPpTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGELTSSSTRTYTVD 159

                          170       180
                   ....*....|....*....|....*
gi 665400030   483 EEQ--RVLGLQVEQRILYRSCLRDD 505
Cdd:pfam07474  160 GEGntRTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
108-262 1.99e-48

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 169.53  E-value: 1.99e-48
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030    108 FYSNVDTsfsdEGTSISLF-ESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYFDSKTDR-LNTFQVALIANE 185
Cdd:smart00539    2 FWADADT----EGTGKVYYrETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDgTNTFQAVLATDG 77

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400030    186 QSTFVQFIYPDGGLNWLQGETAGLGlpdIRAQAGFVAEDGRF-YTLNGSGSENARFLSESTNLGVPGVWLFEVAPIEN 262
Cdd:smart00539   78 SRTYAIFLYPSLGWTSDTTAGGDDG---VRARAGFNGGDGTFsYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 174-257 7.38e-31

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 116.62  E-value: 7.38e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030   174 LNTFQVALIANEQSTFVQFIYPDGGLNWLQGETAGL--GLPDIRAQAGFVAED--GRFYTLNGSGSENARFLSESTNLGV 249
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGtnGLGGTPAQAGFSAGDgdGRYYELPGSGTDSIRNLTETSNVGV 80


                   ....*...
gi 665400030   250 PGVWLFEV 257
Cdd:pfam06119   81 PGRWVFRI 88
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1152-1195 9.15e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 9.15e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 665400030   1152 VIINKQLVNPRGIAVDPYREKLFWSDWDResPKIEMSNLDGTGR 1195
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1107-1145 1.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.99e-10
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 665400030   1107 RPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLD 1145
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
EGF_CA pfam07645
Calcium-binding EGF domain;
591-622 4.01e-10

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.09  E-value: 4.01e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665400030   591 DIDECATGSHVCDENAVCDNTEGGFNCYCTEG 622
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 595-630 3.66e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 3.66e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030   595 CATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRC 630
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-625 5.38e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 5.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665400030  591 DIDECATGsHVCDENAVCDNTEGGFNCYCTEGFEG 625
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1001-1036 7.11e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 7.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030  1001 CLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLC 1036
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
591-630 7.69e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 7.69e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 665400030    591 DIDECATGsHVCDENAVCDNTEGGFNCYCTEGFEgNGYRC 630
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1083-1229 8.13e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 52.29  E-value: 8.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1083 EGRVYWGDISTKKIVSTKYDGTDLRPFITT-----DIESPEGIAIDViSRRLYWADSAKDTIEVASLDDPSLR----AVI 1153
Cdd:cd14963   111 DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgsepgELSYPNGIAVDE-DGNIYVADSGNGRIQVFDKNGKFIKelngSPD 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1154 INKQLVNPRGIAVDPyREKLFWSDwdrespkiEMSN----LDGTGRELL----LGKDDVT--LPNSLVVLENsGEVCYAD 1223
Cdd:cd14963   190 GKSGFVNPRGIAVDP-DGNLYVVD--------NLSHrvyvFDEQGKELFtfggRGKDDGQfnLPNGLFIDDD-GRLYVTD 259


                  ....*.
gi 665400030 1224 AGTKKV 1229
Cdd:cd14963   260 RENNRV 265
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 836-873 3.69e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 3.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665400030   836 CAIRPDICDVHADCVYEEhlGKSECQCQAGYTGNGFNC 873
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTG--GSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1127-1168 3.30e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 3.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 665400030  1127 RRLYWADSAKD-TIEVASLDDPSLRAVIINkQLVNPRGIAVDP 1168
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTD-DLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1074-1254 1.06e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.74  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1074 AIGLDKDcveGRVYWGDISTKKIVSTKYDGTDLRPFITT-----DIESPEGIAIDvISRRLYWADSAKDTIEVASLDDpS 1148
Cdd:cd14956    17 GIAVDAD---DNVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLTG-E 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1149 LRAVIINK-----QLVNPRGIAVDPyREKLFWSDW--DRespkieMSNLDGTGRELLLGKDDVTLPNSL-----VVLENS 1216
Cdd:cd14956    92 LQTIGGSSgsgpgQFNAPRGVAVDA-DGNLYVADFgnQR------IQKFDPDGSFLRQWGGTGIEPGSFnyprgVAVDPD 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 665400030 1217 GEVCYADAGTKKVECIEPQNRQIRTISN------ELSYPFGITF 1254
Cdd:cd14956   165 GTLYVADTYNDRIQVFDNDGAFLRKWGGrgtgpgQFNYPYGIAI 208
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 963-995 1.11e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.11e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665400030   963 NNCGIHATCEPTEDpaNYECQCIAGFKGDGYVC 995
Cdd:pfam12947    6 GGCHPNATCTNTGG--SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 285-320 1.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.27  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665400030   285 CQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSC 320
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1084-1179 1.71e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1084 GRVYWGDISTKKIVSTKYDGTDlrpfittdiesPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIinKQLVNPRG 1163
Cdd:COG3391    90 GRVSVIDLATGKVVATIPVGGG-----------PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI--PVGAGPHG 156

                          90
                  ....*....|....*.
gi 665400030 1164 IAVDPYREKLFWSDWD 1179
Cdd:COG3391   157 IAVDPDGKRLYVANSG 172
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 797-828 1.82e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 1.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665400030   797 NCHINATCNWYGQelRHICTCQPGFRGDGYNC 828
Cdd:pfam12947    7 GCHPNATCTNTGG--SFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1084-1123 2.40e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 2.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665400030  1084 GRVYWGDISTK-KIVSTKYDGTDLRPFITTDIESPEGIAID 1123
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1059-1177 3.17e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.91  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1059 PLNGRNVRPISVAQMAIGLDKDCVEGRVYWGDISTKKIvsTKYDGTDLRPFITTDI-ESPEGIAIDVISRRLYWADSAKD 1137
Cdd:COG3391    97 LATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRV--SVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSN 174

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 665400030 1138 TI----EVASLDDPSLRAVIinKQLVNPRGIAVDPYREKLFWSD 1177
Cdd:COG3391   175 TVsvivSVIDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVAN 216
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 588-624 4.35e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.14  E-value: 4.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 665400030  588 VCLDIDECATGSHVCDEnaVCDNTEGGFNCYCTEGFE 624
Cdd:cd01475   183 ICVVPDLCATLSHVCQQ--VCISTPGSYLCACTEGYA 217
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1084-1273 6.09e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1084 GRVYWGDISTKKIVSTKYDGTDLRPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIinKQLVNPRG 1163
Cdd:COG3391    37 LAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATI--PVGGGPRG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1164 IAVDPYREKLFWSDWDRESpkieMSNLDGTGRELL----LGKDdvtlPNSLVVLENSGEVcY-ADAGTKK----VECIEP 1234
Cdd:COG3391   115 LAVDPDGGRLYVADSGNGR----VSVIDTATGKVVatipVGAG----PHGIAVDPDGKRL-YvANSGSNTvsviVSVIDT 185

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 665400030 1235 QNRQ-IRTISnELSYPFGITFTHDQFY---------WTDWTTKKVEIVD 1273
Cdd:COG3391   186 ATGKvVATIP-VGGGPVGVAVSPDGRRlyvanrgsnTSNGGSNTVSVID 233
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1061-1269 1.06e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1061 NGRNVRPISVAqmaigLDKDcveGRVYWGDISTKKIVstKYD--GTDLRPFITTDIE-----SPEGIAIDvISRRLYWAD 1133
Cdd:cd05819    51 DGQFNEPAGVA-----VDSD---GNLYVADTGNHRIQ--KFDpdGNFLASFGGSGDGdgefnGPRGIAVD-SSGNIYVAD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1134 SAKDTIEVASLDDpSLRAVI-----INKQLVNPRGIAVDPyREKLFWSDW--DRespkIEMSNLDGTGreLLLGKDDVTL 1206
Cdd:cd05819   120 TGNHRIQKFDPDG-EFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTgnHR----IQVFDPDGNF--LTTFGSTGTG 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665400030 1207 PNSL-----VVLENSGEVcY-ADAGTKKVECIEPQNRQI------RTISNELSYPFGITFT-HDQFYWTDWTTKKV 1269
Cdd:cd05819   192 PGQFnyptgIAVDSDGNI-YvADSGNNRVQVFDPDGAGFggngnfLGSDGQFNRPSGLAVDsDGNLYVADTGNNRI 266
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1171-1212 2.68e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 2.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665400030  1171 EKLFWSDWdRESPKIEMSNLDGTGRELLLgKDDVTLPNSLVV 1212
Cdd:pfam00058    1 GRLYWTDS-SLRASISSADLNGSDRKTLF-TDDLQHPNAIAV 40
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1073-1177 5.19e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.26  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1073 MAIGLDKDcveGRVYWGDISTKKIV-------STKYDGTDLRPFITtdieSPEGIAIDViSRRLYWADSAKDTIEVASLD 1145
Cdd:cd14962    15 YGVAADGR---GRIYVADTGRGAVFvfdlpngKVFVIGNAGPNRFV----SPIGVAIDA-NGNLYVSDAELGKVFVFDRD 86

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665400030 1146 DPSLRAVIINKQLVNPRGIAVDPYREKLFWSD 1177
Cdd:cd14962    87 GKFLRAIGAGALFKRPTGIAVDPAGKRLYVVD 118
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1076-1105 5.80e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.04  E-value: 5.80e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 665400030   1076 GLDKDCVEGRVYWGDISTKKIVSTKYDGTD 1105
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 1200-1286 6.66e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.95  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400030 1200 GKDDVTLPNSLVVLeNSGEVCYADAGTKKVECIEPQNRQIRTIS------NELSYPFGITFTHD-QFYWTDWTTKKVEIV 1272
Cdd:cd14961     6 WPGTLNNPTGVAVT-PTGRVVVADDGNKRIQVFDSDGNCLQQFGpkgdagQDIRYPLDVAVTPDgHIVVTDAGDRSVKVF 84

                          90
                  ....*....|....
gi 665400030 1273 DSLGARQTPIQPPF 1286
Cdd:cd14961    85 SFDGRLKLFVRKSF 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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