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Conserved domains on  [gi|281364133|ref|NP_995929|]
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Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2, isoform D [Drosophila melanogaster]

Protein Classification

peptidyl-alpha-hydroxyglycine alpha-amidating lyase family protein( domain architecture ID 10202478)

peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) family protein may catalyze the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate; similar to Drosophila melanogaster PAL1 and PAL2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 102-404 6.90e-129

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 373.14  E-value: 6.90e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 102 VENWPTEQHSFGQVTAVAVDPQGSPVVFHRAERYWDVNTFNEsNIYYLIeyGPIKENTIYVLDAKTGAIKSgWGSNMFYM 181
Cdd:cd14958    2 VSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFK--GPIEEDTILVFDPDGGFLRS-WGAGLFYM 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 182 PHGLTIDLHGNYWITDVAMHQAFKFKPFSNK-PLLTIGKRFRPGSSVKHLCKPTSIAVATTGEFFIADGYCNSRILKFNA 260
Cdd:cd14958   78 PHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLlPLLTLGERGEPGSDQTHFCKPTDVAVAPDGDIFVADGYCNSRIVKFSP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 261 AGKLLRTIPQP-PEFLSLQVPHAITLLEHlDLLCIADRENMRVVCPKAglisshgEGEPAATIQEPDLGRVFGVASFGD- 338
Cdd:cd14958  158 DGKLLKSWGEPgSGPGQFNLPHSIALDED-GRVYVADRENGRIQVFDA-------DGKFLTEWTNPELGRPYALAIDPDg 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281364133 339 IVFAVNGPTS---MLPVRGFTIDPRSETIIGHWG-------EFKNPHSMAVSVNGSaLYVTEIGtnhqTNRVWKYV 404
Cdd:cd14958  230 LLYVVDGPPRlnrSLPVRGFVIRIGKGLILGRFGpggkapgQFQNPHDIAVDSGGD-IYVGELG----PNRVQKFV 300
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 102-404 6.90e-129

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 373.14  E-value: 6.90e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 102 VENWPTEQHSFGQVTAVAVDPQGSPVVFHRAERYWDVNTFNEsNIYYLIeyGPIKENTIYVLDAKTGAIKSgWGSNMFYM 181
Cdd:cd14958    2 VSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFK--GPIEEDTILVFDPDGGFLRS-WGAGLFYM 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 182 PHGLTIDLHGNYWITDVAMHQAFKFKPFSNK-PLLTIGKRFRPGSSVKHLCKPTSIAVATTGEFFIADGYCNSRILKFNA 260
Cdd:cd14958   78 PHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLlPLLTLGERGEPGSDQTHFCKPTDVAVAPDGDIFVADGYCNSRIVKFSP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 261 AGKLLRTIPQP-PEFLSLQVPHAITLLEHlDLLCIADRENMRVVCPKAglisshgEGEPAATIQEPDLGRVFGVASFGD- 338
Cdd:cd14958  158 DGKLLKSWGEPgSGPGQFNLPHSIALDED-GRVYVADRENGRIQVFDA-------DGKFLTEWTNPELGRPYALAIDPDg 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281364133 339 IVFAVNGPTS---MLPVRGFTIDPRSETIIGHWG-------EFKNPHSMAVSVNGSaLYVTEIGtnhqTNRVWKYV 404
Cdd:cd14958  230 LLYVVDGPPRlnrSLPVRGFVIRIGKGLILGRFGpggkapgQFQNPHDIAVDSGGD-IYVGELG----PNRVQKFV 300
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
111-394 2.24e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 54.64  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 111 SFGQVTAVAVDPQGspvvfhraeRYWDVNTFNesniyylieygpikeNTIYVLDAKTGAIKSgWGSNMFYMPHGLTIDLH 190
Cdd:COG4257   15 PGSGPRDVAVDPDG---------AVWFTDQGG---------------GRIGRLDPATGEFTE-YPLGGGSGPHGIAVDPD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 191 GNYWITDVAMHQAFKFKPFSNKPlltigKRFRPGSSVKHlckPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTIPQ 270
Cdd:COG4257   70 GNLWFTDNGNNRIGRIDPKTGEI-----TTFALPGGGSN---PHGIAFDPDGNLWFTDQG-GNRIGRLDPATGEVTEFPL 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 271 PpefLSLQVPHAITlLEHLDLLCIADRENMRVVC--PKAGLISSHgegEPAATIQEPdlgRVFGVASFGDIVFAVNGPTS 348
Cdd:COG4257  141 P---TGGAGPYGIA-VDPDGNLWVTDFGANAIGRidPDTGTLTEY---ALPTPGAGP---RGLAVDPDGNLWVADTGSGR 210

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 281364133 349 mlpVRGFtiDPRSETI--IGHWGEFKNPHSMAVSVNGsALYVTEIGTN 394
Cdd:COG4257  211 ---IGRF--DPKTGTVteYPLPGGGARPYGVAVDGDG-RVWFAESGAN 252
Phytase-like pfam13449
Esterase-like activity of phytase; This is a repeated domain that carries several highly ...
 235-282 6.28e-04

Esterase-like activity of phytase; This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.


Pssm-ID: 433217 [Multi-domain]  Cd Length: 284  Bit Score: 41.50  E-value: 6.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281364133  235 SIAVATTGEFFIADGYcNSRILKFNAAGKLLRTIPQPPEFLSLQVPHA 282
Cdd:pfam13449  72 GIAVAPDGTFWVSSEG-GPFILRFDLDGRLLRELPLPADFLPDPSPDA 118
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 102-404 6.90e-129

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 373.14  E-value: 6.90e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 102 VENWPTEQHSFGQVTAVAVDPQGSPVVFHRAERYWDVNTFNEsNIYYLIeyGPIKENTIYVLDAKTGAIKSgWGSNMFYM 181
Cdd:cd14958    2 VSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFK--GPIEEDTILVFDPDGGFLRS-WGAGLFYM 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 182 PHGLTIDLHGNYWITDVAMHQAFKFKPFSNK-PLLTIGKRFRPGSSVKHLCKPTSIAVATTGEFFIADGYCNSRILKFNA 260
Cdd:cd14958   78 PHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLlPLLTLGERGEPGSDQTHFCKPTDVAVAPDGDIFVADGYCNSRIVKFSP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 261 AGKLLRTIPQP-PEFLSLQVPHAITLLEHlDLLCIADRENMRVVCPKAglisshgEGEPAATIQEPDLGRVFGVASFGD- 338
Cdd:cd14958  158 DGKLLKSWGEPgSGPGQFNLPHSIALDED-GRVYVADRENGRIQVFDA-------DGKFLTEWTNPELGRPYALAIDPDg 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281364133 339 IVFAVNGPTS---MLPVRGFTIDPRSETIIGHWG-------EFKNPHSMAVSVNGSaLYVTEIGtnhqTNRVWKYV 404
Cdd:cd14958  230 LLYVVDGPPRlnrSLPVRGFVIRIGKGLILGRFGpggkapgQFQNPHDIAVDSGGD-IYVGELG----PNRVQKFV 300
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 112-403 6.33e-27

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 108.17  E-value: 6.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 112 FGQVTAVAVDPQGSPVVfhraerywdVNTFNesniyylieygpikeNTIYVLDAKTGAIKS----GWGSNMFYMPHGLTI 187
Cdd:cd05819    7 LNNPQGIAVDSSGNIYV---------ADTGN---------------NRIQVFDPDGNFITSfgsfGSGDGQFNEPAGVAV 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 188 DLHGNYWITDVAMHQAFKFKPfSNKPLLTIGKrfrPGSSVKHLCKPTSIAVATTGEFFIADgYCNSRILKFNAAGKLLRT 267
Cdd:cd05819   63 DSDGNLYVADTGNHRIQKFDP-DGNFLASFGG---SGDGDGEFNGPRGIAVDSSGNIYVAD-TGNHRIQKFDPDGEFLTT 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 268 IPQPPEFL-SLQVPHAITlLEHLDLLCIADRENMRVVC--PKAGLISSHGEGEPAatiqEPDLGRVFGVA--SFGDIVFA 342
Cdd:cd05819  138 FGSGGSGPgQFNGPTGVA-VDSDGNIYVADTGNHRIQVfdPDGNFLTTFGSTGTG----PGQFNYPTGIAvdSDGNIYVA 212

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281364133 343 vngPTSMLPVRGFTIDPRSETIIG----HWGEFKNPHSMAVSVNGSaLYVTEIGtnhqTNRVWKY 403
Cdd:cd05819  213 ---DSGNNRVQVFDPDGAGFGGNGnflgSDGQFNRPSGLAVDSDGN-LYVADTG----NNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 173-403 8.10e-22

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 93.92  E-value: 8.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 173 GWGSNMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGKRfrpGSSVKHLCKPTSIAVATTGEFFIADGYcN 252
Cdd:cd05819    1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDP-DGNFITSFGSF---GSGDGQFNEPAGVAVDSDGNLYVADTG-N 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 253 SRILKFNAAGKLLRTIPQPPEFLS-LQVPHAITlLEHLDLLCIADRENMRVVC--PKAGLISSHG-EGEPAATIQEPdlg 328
Cdd:cd05819   76 HRIQKFDPDGNFLASFGGSGDGDGeFNGPRGIA-VDSSGNIYVADTGNHRIQKfdPDGEFLTTFGsGGSGPGQFNGP--- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 329 rvFGVA--SFGDIVFAVNGPTSmlpVRGFTIDPRSETIIGHWG----EFKNPHSMAVSVNGSaLYVteigTNHQTNRVWK 402
Cdd:cd05819  152 --TGVAvdSDGNIYVADTGNHR---IQVFDPDGNFLTTFGSTGtgpgQFNYPTGIAVDSDGN-IYV----ADSGNNRVQV 221


                 .
gi 281364133 403 Y 403
Cdd:cd05819  222 F 222
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 156-395 3.85e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 69.23  E-value: 3.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 156 KENTIYVLDA---------KTGAIKSGWGS-----NMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGkrf 221
Cdd:cd14956   22 ADDNVYVADArngriqvfdKDGTFLRRFGTtgdgpGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTL-TGELQTIGG--- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 222 RPGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTIPQPP-EFLSLQVPHAITLLEHLDLLcIADRENM 300
Cdd:cd14956   98 SSGSGPGQFNAPRGVAVDADGNLYVADFG-NQRIQKFDPDGSFLRQWGGTGiEPGSFNYPRGVAVDPDGTLY-VADTYND 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 301 RV-VCPKAGLISSH------GEGE---PAATIQEPDlGRVFgVASFGdivfavNGptsmlPVRGFTIDPRSETIIGHW-- 368
Cdd:cd14956  176 RIqVFDNDGAFLRKwggrgtGPGQfnyPYGIAIDPD-GNVF-VADFG------NN-----RIQKFTADGTFLTSWGSPgt 242

                        250       260
                 ....*....|....*....|....*....
gi 281364133 369 --GEFKNPHSMAVSVNGSaLYVTEIGTNH 395
Cdd:cd14956  243 gpGQFKNPWGVVVDADGT-VYVADSNNNR 270
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 160-302 6.57e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 59.52  E-value: 6.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 160 IYVLDAKTGAIK---------SGWGS---NMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPFsNKPLLTIGKRFRpgssv 227
Cdd:cd14962   25 IYVADTGRGAVFvfdlpngkvFVIGNagpNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRD-GKFLRAIGAGAL----- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 228 khLCKPTSIAVATTGEF-FIADGYcNSRILKFNAAGKLLRTIPQ----PPEFlslQVPHAITLLeHLDLLCIADRENMRV 302
Cdd:cd14962   99 --FKRPTGIAVDPAGKRlYVVDTL-AHKVKVFDLDGRLLFDIGKrgsgPGEF---NLPTDLAVD-RDGNLYVTDTMNFRV 171
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 160-265 8.94e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 59.13  E-value: 8.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 160 IYVLDA---------KTGAIKSGWGS-----NMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPFSNkpLLTigKRFRPGS 225
Cdd:cd14955  123 VYVTDSgnnriqkfdSSGTFITKWGSfgsgdGQFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTGT--FLT--KWGSEGS 198

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 281364133 226 SVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLL 265
Cdd:cd14955  199 GDGQFNAPYGIAVDSAGNVYVADTG-NNRIQKFDSSGTFI 237
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 173-303 1.35e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 55.38  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 173 GWGSNMFYMPHGLTIDlHGNYWITDVAMHQAFKFKPfSNKPLLTIGKrfrPGSSVKHLCKPTSIAVATTGEFFIADGYcN 252
Cdd:cd14963    3 GPFGDPLNKPMGVAVS-DGRIYVADTNNHRVQVFDY-EGKFKKSFGG---PGTGPGEFKYPYGIAVDSDGNIYVADLY-N 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 281364133 253 SRILKFNAAGKLLRTIPQPPEFLSLQVPHAITLleHLDLLCIADRENMRVV 303
Cdd:cd14963   77 GRIQVFDPDGKFLKYFPEKKDRVKLISPAGLAI--DDGKLYVSDVKKHKVI 125
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 160-267 1.41e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 55.66  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 160 IYVLDA------K---TGAIKSGWGS-----NMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGKRfrpGS 225
Cdd:cd14955   76 VYVADTgnhriqKfdsTGTFLTKWGSsgsgdGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDS-SGTFITKWGSF---GS 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 281364133 226 SVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRT 267
Cdd:cd14955  152 GDGQFNSPTGIAVDSAGNVYVADTG-NNRIQKFTSTGTFLTK 192
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 173-403 1.81e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 54.98  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 173 GWGSNMFYMPHGLTIDLHGNYWITDVAMH--QAFKfkpfsnKPLLTIGKRFRPGSSVKHLCKPTSIAVATTGEFFIADgY 250
Cdd:cd14956    6 GSGPGQFKDPRGIAVDADDNVYVADARNGriQVFD------KDGTFLRRFGTTGDGPGQFGRPRGLAVDKDGWLYVAD-Y 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 251 CNSRILKFNAAGKLLRTI----PQPPEFLSlqvPHAITLLEHLDLLcIADRENMRVV--CPKAGLISSHGE-GEPAATIQ 323
Cdd:cd14956   79 WGDRIQVFTLTGELQTIGgssgSGPGQFNA---PRGVAVDADGNLY-VADFGNQRIQkfDPDGSFLRQWGGtGIEPGSFN 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 324 EPdlgRVFGVASFGDiVFAVNGPTSMLPVrgFTIDPRsetIIGHWG-------EFKNPHSMAVSVNGSaLYVTEIGtnhq 396
Cdd:cd14956  155 YP---RGVAVDPDGT-LYVADTYNDRIQV--FDNDGA---FLRKWGgrgtgpgQFNYPYGIAIDPDGN-VFVADFG---- 220


                 ....*..
gi 281364133 397 TNRVWKY 403
Cdd:cd14956  221 NNRIQKF 227
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
111-394 2.24e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 54.64  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 111 SFGQVTAVAVDPQGspvvfhraeRYWDVNTFNesniyylieygpikeNTIYVLDAKTGAIKSgWGSNMFYMPHGLTIDLH 190
Cdd:COG4257   15 PGSGPRDVAVDPDG---------AVWFTDQGG---------------GRIGRLDPATGEFTE-YPLGGGSGPHGIAVDPD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 191 GNYWITDVAMHQAFKFKPFSNKPlltigKRFRPGSSVKHlckPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTIPQ 270
Cdd:COG4257   70 GNLWFTDNGNNRIGRIDPKTGEI-----TTFALPGGGSN---PHGIAFDPDGNLWFTDQG-GNRIGRLDPATGEVTEFPL 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 271 PpefLSLQVPHAITlLEHLDLLCIADRENMRVVC--PKAGLISSHgegEPAATIQEPdlgRVFGVASFGDIVFAVNGPTS 348
Cdd:COG4257  141 P---TGGAGPYGIA-VDPDGNLWVTDFGANAIGRidPDTGTLTEY---ALPTPGAGP---RGLAVDPDGNLWVADTGSGR 210

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 281364133 349 mlpVRGFtiDPRSETI--IGHWGEFKNPHSMAVSVNGsALYVTEIGTN 394
Cdd:COG4257  211 ---IGRF--DPKTGTVteYPLPGGGARPYGVAVDGDG-RVWFAESGAN 252
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 157-265 2.66e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 54.50  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 157 ENTIYVLD---------AKTGAIKSGWGSN-----MFYMPHGLTIDLHGNYWITDVAMHQAFKFKpfSNKPLLTigKRFR 222
Cdd:cd14955   26 AGNVYVADtgnnriqkfDSTGTFLTKWGSSgsgdgQFYSPTGIAVDSDGNVYVADTGNHRIQKFD--STGTFLT--KWGS 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 281364133 223 PGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLL 265
Cdd:cd14955  102 SGSGDGQFNSPSGIAVDSAGNVYVTDSG-NNRIQKFDSSGTFI 143
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 157-268 8.16e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 52.97  E-value: 8.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 157 ENTIYVLDAKTGAI----KSGW------GSNMFYMPHGLTIDLHGNY-WITDVAMHQAFKFKPfSNKPLLTIGKRfrpGS 225
Cdd:cd14962   67 NGNLYVSDAELGKVfvfdRDGKflraigAGALFKRPTGIAVDPAGKRlYVVDTLAHKVKVFDL-DGRLLFDIGKR---GS 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 281364133 226 SVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTI 268
Cdd:cd14962  143 GPGEFNLPTDLAVDRDGNLYVTDTM-NFRVQIFDADGKFLRSF 184
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
245-406 1.32e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.00  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 245 FIADGYcNSRILKFNAA-GKLLRTIPQPPEflslqvPHAITLLEHLDLLCIADRENMRVV---CPKAGLISSHGEG-EPA 319
Cdd:COG3391   83 YVANSG-SGRVSVIDLAtGKVVATIPVGGG------PRGLAVDPDGGRLYVADSGNGRVSvidTATGKVVATIPVGaGPH 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 320 ATIQEPDLGRVFgVASFGD----IVFAVngptsmlpvrgftIDPRSETIIGHWGEFKNPHSMAVSVNGSALYVTEIGTNH 395
Cdd:COG3391  156 GIAVDPDGKRLY-VANSGSntvsVIVSV-------------IDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNT 221

                        170
                 ....*....|....
gi 281364133 396 ---QTNRVWKYVLA 406
Cdd:COG3391  222 sngGSNTVSVIDLA 235
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 171-268 6.92e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 50.34  E-value: 6.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 171 KSGWGSNMFYMPHGLTIDLHGNYWITDVAMH--QAFKFkpfSNKPLLTIGKrfrPGSSVKHLCKPTSIAVATTGEFFIAD 248
Cdd:cd14957    9 SNGSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVFTS---SGVYSYSIGS---GGTGSGQFNSPYGIAVDSNGNIYVAD 82

                         90       100
                 ....*....|....*....|
gi 281364133 249 gYCNSRILKFNAAGKLLRTI 268
Cdd:cd14957   83 -TDNNRIQVFNSSGVYQYSI 101
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 156-268 7.10e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 50.37  E-value: 7.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 156 KENTIYVLDAKTGAI----KSGWGSNMF---------YMPHGLTIDlHGNYWITDVAMHQAFKFKPFSNKpLLTIGKrfr 222
Cdd:cd14963   65 SDGNIYVADLYNGRIqvfdPDGKFLKYFpekkdrvklISPAGLAID-DGKLYVSDVKKHKVIVFDLEGKL-LLEFGK--- 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 281364133 223 PGSSVKHLCKPTSIAVATTGEFFIAD-GycNSRILKFNAAGKLLRTI 268
Cdd:cd14963  140 PGSEPGELSYPNGIAVDEDGNIYVADsG--NGRIQVFDKNGKFIKEL 184
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 112-303 1.11e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 49.59  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 112 FGQVTAVAVDPQGSpvvfhraerywdvntfnesniYYLIEYGpikENTIYVLDAKTGAIKSgWGSN-----MFYMPHGLT 186
Cdd:cd14956  106 FNAPRGVAVDADGN---------------------LYVADFG---NQRIQKFDPDGSFLRQ-WGGTgiepgSFNYPRGVA 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 187 IDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGKRFR-PGssvkHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLL 265
Cdd:cd14956  161 VDPDGTLYVADTYNDRIQVFDN-DGAFLRKWGGRGTgPG----QFNYPYGIAIDPDGNVFVADFG-NNRIQKFTADGTFL 234

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 281364133 266 RTIPQPP-EFLSLQVPHAITlLEHLDLLCIADRENMRVV 303
Cdd:cd14956  235 TSWGSPGtGPGQFKNPWGVV-VDADGTVYVADSNNNRVQ 272
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 157-394 1.69e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 49.21  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 157 ENTIYVLDAKTGAI--------------KSGWGSNMFYMPHGLTIDLHGNYWITDVAMH--QAF----KFKpfsnkpllt 216
Cdd:cd14963   19 DGRIYVADTNNHRVqvfdyegkfkksfgGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGriQVFdpdgKFL--------- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 217 igKRFRPGSSVKHLCKPTSIAVaTTGEFFIAD-GYcnSRILKFNAAGKLLRTIPQPPEFL-SLQVPHAITLLEHlDLLCI 294
Cdd:cd14963   90 --KYFPEKKDRVKLISPAGLAI-DDGKLYVSDvKK--HKVIVFDLEGKLLLEFGKPGSEPgELSYPNGIAVDED-GNIYV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 295 ADRENMRV-VCPKaglisshgEGEPAATIQ-EPDLGRVF----GVASFGDI-VFAVNGPTSMlpVRGFTIDPRSETIIGH 367
Cdd:cd14963  164 ADSGNGRIqVFDK--------NGKFIKELNgSPDGKSGFvnprGIAVDPDGnLYVVDNLSHR--VYVFDEQGKELFTFGG 233

                        250       260       270
                 ....*....|....*....|....*....|.
gi 281364133 368 WG----EFKNPHSMAVSVNGsALYVTEIGTN 394
Cdd:cd14963  234 RGkddgQFNLPNGLFIDDDG-RLYVTDRENN 263
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 104-304 4.85e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 47.66  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 104 NWPTEqhsFGQVTAVAVDPQGSPVVFHRAERywDVNTFNeSNIYYLIEYGPI----------------KENTIYVLDAKT 167
Cdd:cd14961    5 GWPGT---LNNPTGVAVTPTGRVVVADDGNK--RIQVFD-SDGNCLQQFGPKgdagqdirypldvavtPDGHIVVTDAGD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 168 GAIK----SG----WGSNMFYMPHGLTIDLHGNYWITDVAMHQAFKFKpfSNKPLLTIGKRFRPGSsvkHLCKPTSIAVA 239
Cdd:cd14961   79 RSVKvfsfDGrlklFVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLT--VDFKLGILKKGQKLCS---QLCRPRFVAVS 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281364133 240 TTGE-------FFIADGYCNSRILKFNAAGKLLRTIPQppEFLSLQVPHAITL----LEHLDLLCIADRENMRVVC 304
Cdd:cd14961  154 RLGAvavtehlFANGTRSSSTRVKVFSSGGQLLGQIDS--FGLNLVFPSLICAsgvaFDSEGNVIVADTGSGAILC 227
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 172-267 1.18e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 46.42  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 172 SGWGSNMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGkrfRPGSSVKHLCKPTSIAVATTGEFFIADGYc 251
Cdd:cd14955    8 YGSGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDS-TGTFLTKWG---SSGSGDGQFYSPTGIAVDSDGNVYVADTG- 82

                         90
                 ....*....|....*.
gi 281364133 252 NSRILKFNAAGKLLRT 267
Cdd:cd14955   83 NHRIQKFDSTGTFLTK 98
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 145-302 1.53e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 46.11  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 145 NIYYLIEYGpikeNTIYVLDAKTG---AIKSGW-GSNMFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGKR 220
Cdd:cd14957   77 NIYVADTDN----NRIQVFNSSGVyqySIGTGGsGDGQFNGPYGIAVDSNGNIYVADTGNHRIQVFTS-SGTFSYSIGSG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 221 frpGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTI----PQPPEFLSlqvPHAITlLEHLDLLCIAD 296
Cdd:cd14957  152 ---GTGPGQFNGPQGIAVDSDGNIYVADTG-NHRIQVFTSSGTFQYTFgssgSGPGQFSD---PYGIA-VDSDGNIYVAD 223


                 ....*.
gi 281364133 297 RENMRV 302
Cdd:cd14957  224 TGNHRI 229
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 182-402 3.51e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.89  E-value: 3.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 182 PHGLTIDLHGNYWITDVAMHQAFKFKPFSNKP-LLTIGKrfrpgssvkhLCKPTSIAVATTGEFFIADGYcNSRILKFnA 260
Cdd:cd14952   12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQtVLPFTG----------LYQPQGVAVDAAGTVYVTDFG-NNRVLKL-A 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 261 AGkllRTIPQPPEFLSLQVPHAITLLEHLDLLcIADRENMRVVCPKAGlisshgegepaATIQE----PDLGRVFGVA-- 334
Cdd:cd14952   80 AG---STTQTVLPFTGLNDPTGVAVDAAGNVY-VADTGNNRVLKLAAG-----------SNTQTvlpfTGLSNPDGVAvd 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 335 SFGDIVFA-------------VNGPTSmLPvrgFTidprsetiighwgEFKNPHSMAVSVNGsALYVTEigtnHQTNRVW 401
Cdd:cd14952  145 GAGNVYVTdtgnnrvlklaagSTTQTV-LP---FT-------------GLNSPSGVAVDTAG-NVYVTD----HGNNRVL 202


                 .
gi 281364133 402 K 402
Cdd:cd14952  203 K 203
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 157-259 4.39e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 44.87  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 157 ENTIYVLDAKTGAIK----SG-----WGSN-----MFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGKRfr 222
Cdd:cd14955  167 AGNVYVADTGNNRIQkftsTGtfltkWGSEgsgdgQFNAPYGIAVDSAGNVYVADTGNNRIQKFDS-SGTFITKWGSE-- 243

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 281364133 223 pGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFN 259
Cdd:cd14955  244 -GSGDGQFNSPSGIAVDSAGNVYVADSG-NNRIQKFA 278
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
68-303 1.05e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.53  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133  68 LAMPLTDDDAVALQNQRSYDNVPLPAASVPTPVLVENWPTEQHSFGQVTAVAVDPQGSPVVFHRAERYWDVNTFNESNIY 147
Cdd:COG3391    4 ASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 148 YLIEYGpikeNTIYVLDAKTGAIKSGWGSNmfYMPHGLTIDLHGNY-WITDVAMHQAFKFKPFSNKPLltigKRFRPGSS 226
Cdd:COG3391   84 VANSGS----GRVSVIDLATGKVVATIPVG--GGPRGLAVDPDGGRlYVADSGNGRVSVIDTATGKVV----ATIPVGAG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 227 vkhlckPTSIAVATTG-EFFIADGYCN--SRIL-KFNAA-GKLLRTIPQPpeflslQVPHAITLLEHLDLLCIADRENMR 301
Cdd:COG3391  154 ------PHGIAVDPDGkRLYVANSGSNtvSVIVsVIDTAtGKVVATIPVG------GGPVGVAVSPDGRRLYVANRGSNT 221


                 ..
gi 281364133 302 VV 303
Cdd:COG3391  222 SN 223
Phytase-like pfam13449
Esterase-like activity of phytase; This is a repeated domain that carries several highly ...
 235-282 6.28e-04

Esterase-like activity of phytase; This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.


Pssm-ID: 433217 [Multi-domain]  Cd Length: 284  Bit Score: 41.50  E-value: 6.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281364133  235 SIAVATTGEFFIADGYcNSRILKFNAAGKLLRTIPQPPEFLSLQVPHA 282
Cdd:pfam13449  72 GIAVAPDGTFWVSSEG-GPFILRFDLDGRLLRELPLPADFLPDPSPDA 118
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 156-302 1.20e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.61  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 156 KENTIYVLD----------------AKTGAIKSGWGSnmFYMPHGLTIDLHGNYWITDVAMHQAFKFKPfSNKPLLTIGK 219
Cdd:cd14954  127 SEGRIYVSDtrnhrvqvfdsdgqfiRKFGFEGAGPGQ--LDSPRGVAVNPDGNIVVSDFNNHRLQVFDP-DGQFLRFFGS 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 220 rfrPGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTI-PQPPEFLSLQVPHAITLLEHLDLLcIADRE 298
Cdd:cd14954  204 ---EGSGNGQFKRPRGVAVDDEGNIIVADSG-NHRVQVFSPDGEFLCSFgTEGNGEGQFDRPSGVAVTPDGRIV-VVDRG 278


                 ....
gi 281364133 299 NMRV 302
Cdd:cd14954  279 NHRI 282
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 159-259 2.69e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 39.17  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 159 TIYVLDAKTGAIK--------------SGWGSNMFYMPHGLTIDLHGNYWITDVAMHqafKFKPFSNKP--LLTIGKRfr 222
Cdd:cd14957  171 NIYVADTGNHRIQvftssgtfqytfgsSGSGPGQFSDPYGIAVDSDGNIYVADTGNH---RIQVFTSSGayQYSIGTS-- 245

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 281364133 223 pGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFN 259
Cdd:cd14957  246 -GSGNGQFNYPYGIAVDNDGKIYVADSN-NNRIQVFN 280
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 210-302 3.32e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 39.07  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364133 210 SNKPLLTIGKRfrpGSSVKHLCKPTSIAVATTGEFFIADGYcNSRILKFNAAGKLLRTIPQ----PPEFLSlqvPHAITL 285
Cdd:cd14954    6 KGRPLLSFGKE---GSKDGELCRPWGVAVDKDGRIIVADRS-NNRVQVFDPDGKFLRKFGSygsrDGQFDR---PAGVAV 78

                         90
                 ....*....|....*..
gi 281364133 286 LEHLDLLcIADRENMRV 302
Cdd:cd14954   79 NSRGRII-VADKDNHRI 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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