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Conserved domains on  [gi|221330798|ref|NP_995978|]
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uncharacterized protein Dmel_CG33233, isoform C [Drosophila melanogaster]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 49-295 3.23e-21

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 96.24  E-value: 3.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   49 CEFD---TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSA 125
Cdd:TIGR00898 117 TEWDlvcEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  126 VASLQVGFLGEFHAIKWRpITVAICSQSQ-GLALIYCPLVAMAIlpnnfnvdlsssynlRVWRFLMMFFMIPGWLALVGI 204
Cdd:TIGR00898 197 IWVQAVVLNTEFLPKKQR-AIVGTLIQVFfSLGLVLLPLVAYFI---------------PDWRWLQLAVSLPTFLFFLLS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  205 CLVPETPHFLMSVNRPDKALLALKWICRMNRKKwedvdiTLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICL-F 283
Cdd:TIGR00898 261 WFVPESPRWLISQGRIEEALKILQRIAKINGKK------LPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmM 334

                         250
                  ....*....|..
gi 221330798  284 LIFGIFFTSIGL 295
Cdd:TIGR00898 335 LWFTTAFSYYGL 346
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 49-295 3.23e-21

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 96.24  E-value: 3.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   49 CEFD---TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSA 125
Cdd:TIGR00898 117 TEWDlvcEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  126 VASLQVGFLGEFHAIKWRpITVAICSQSQ-GLALIYCPLVAMAIlpnnfnvdlsssynlRVWRFLMMFFMIPGWLALVGI 204
Cdd:TIGR00898 197 IWVQAVVLNTEFLPKKQR-AIVGTLIQVFfSLGLVLLPLVAYFI---------------PDWRWLQLAVSLPTFLFFLLS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  205 CLVPETPHFLMSVNRPDKALLALKWICRMNRKKwedvdiTLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICL-F 283
Cdd:TIGR00898 261 WFVPESPRWLISQGRIEEALKILQRIAKINGKK------LPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmM 334

                         250
                  ....*....|..
gi 221330798  284 LIFGIFFTSIGL 295
Cdd:TIGR00898 335 LWFTTAFSYYGL 346
Sugar_tr pfam00083
Sugar (and other) transporter;
28-293 5.66e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 73.85  E-value: 5.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   28 FIYMYSVTESMTAGYLVVLTScefdtspkekTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMP 107
Cdd:pfam00083  28 FFKNFGLSKSVSSLAALSVLS----------GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  108 DLYSLSVI---RIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAIcsqsQGLALIYCPLVAMAilpnnFNVDLSSSYNLR 184
Cdd:pfam00083  98 GKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL----YQLAITFGILLAYI-----FGLGLNKTSNSD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  185 VWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWIcrmnrKKWEDVDITLSEEKSSTNDQEGFWKTVWY 264
Cdd:pfam00083 169 GWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKL-----RGVPDVDRELDEIKDSLEAGQEAEKASWK 243

                         250       260
                  ....*....|....*....|....*....
gi 221330798  265 EykLLFSKPHVFKFFICLFLIFGIFFTSI 293
Cdd:pfam00083 244 E--LFSTKTRRQRLLIGVMLQIFQQLTGI 270
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 45-461 3.01e-13

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 71.49  E-value: 3.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  45 VLTSCEFDT--SPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTF 122
Cdd:cd17438   21 VLPSAEKDMclSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 123 LSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFMIPGWLAL 201
Cdd:cd17438  101 IGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHyGWGFSMGTNYHFHSWRVFVIICALPCIASI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 202 VGICLVPETPHFLMSVNRPDKALLALKWI--CRMNRKKWEDVDITLSEEKSSTNDqegFWKTVWyeykllfskphvfkff 279
Cdd:cd17438  181 IALKFMPESPRFLLEMGKHDEAWMILKNIhdTNMRAKGTPEKVFTVSNIKRKNTL---FLAVVW---------------- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 280 iclfliFGIFFTSIGLGIWFP-VIRNMDNSGSNR--------LCDLVNNNPTFINHEADDT------------------N 332
Cdd:cd17438  242 ------FTMAFSYYGLTVWFPdMIRYLQKHVTFEdslfdecyFEDVTSTDTYFKNCTIESTifyntdlyehkfidcrfiN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 333 GTDSESPK-CNDEMTNLIDPVYYGFTYIGCF------ILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIFF 405
Cdd:cd17438  316 STFLEQKEgCHMDFEEDNDFLIYLVSFLGSLsvlpgnIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQ 395

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221330798 406 VLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVT 461
Cdd:cd17438  396 CLFCGTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILGNSIFASFVGIT 451
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-212 1.75e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.22  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  21 IIFMVSFFIYMYSVTESMTAGYLVVLTScEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFS 100
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 101 VISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAmAILPNNFNvdlsss 180
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG-GLLADLFG------ 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 221330798 181 ynlrvWRFLMMFFMIPGWLALVGI-CLVPETPH 212
Cdd:COG2814  163 -----WRWVFLVNAVLALLALLLLlRLLPESRP 190
xylE PRK10077
D-xylose transporter XylE; Provisional
 61-230 7.52e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 48.15  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  61 LANSLLGGMVAS--------GLFIGFLADRYGRKFVIRLAlvgALSFsVISAL----------------MPDLYSLSVIR 116
Cdd:PRK10077  52 AANSLLGFCVASaligciigGALGGYCSNRFGRRDSLKIA---AVLF-FISALgsawpefgftsigpdnTGYVPEFVIYR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 117 IIVGTFLSAVASLQVGFLGEFHAIKWRPITVAiCSQsqgLALIYCPLVAMAIlpnNFNVDLSSS---YNLRVWRFLMMFF 193
Cdd:PRK10077 128 IIGGIGVGLASMLSPMYIAEIAPAHIRGKLVS-FNQ---FAIIFGQLVVYFV---NYFIARSGDaswLNTDGWRYMFASE 200

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 221330798 194 MIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWI 230
Cdd:PRK10077 201 AIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKI 237
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 49-295 3.23e-21

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 96.24  E-value: 3.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   49 CEFD---TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSA 125
Cdd:TIGR00898 117 TEWDlvcEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGG 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  126 VASLQVGFLGEFHAIKWRpITVAICSQSQ-GLALIYCPLVAMAIlpnnfnvdlsssynlRVWRFLMMFFMIPGWLALVGI 204
Cdd:TIGR00898 197 IWVQAVVLNTEFLPKKQR-AIVGTLIQVFfSLGLVLLPLVAYFI---------------PDWRWLQLAVSLPTFLFFLLS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  205 CLVPETPHFLMSVNRPDKALLALKWICRMNRKKwedvdiTLSEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFKFFICL-F 283
Cdd:TIGR00898 261 WFVPESPRWLISQGRIEEALKILQRIAKINGKK------LPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmM 334

                         250
                  ....*....|..
gi 221330798  284 LIFGIFFTSIGL 295
Cdd:TIGR00898 335 LWFTTAFSYYGL 346
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 3-305 7.15e-15

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 77.32  E-value: 7.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798    3 AMDVDTALLTIGYGLGQVIIFMVSFFIYMYSVTESMTAGYlvVLTSCEFDT--SPKEKTLLANSLLGGMVASGLFIGFLA 80
Cdd:TIGR01299 149 AQQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGF--VLPSAEKDLciPDSGKGMLGLIVYLGMMVGAFFWGGLA 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   81 DRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIY 160
Cdd:TIGR01299 227 DKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIY 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  161 CPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWICRMNRKKWE 239
Cdd:TIGR01299 307 AAAMAWAIIPHyGWSFQMGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAKG 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  240 DVDITLSEEKSSTNDQE----------GFWKT------------VWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGLGI 297
Cdd:TIGR01299 387 HPEKVFSVNHIKTIHQEdelieiesdtGTWYQrcfvralsegggIWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGLSV 466


                  ....*....
gi 221330798  298 WFP-VIRNM 305
Cdd:TIGR01299 467 WFPdMIKHL 475
Sugar_tr pfam00083
Sugar (and other) transporter;
28-293 5.66e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 73.85  E-value: 5.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   28 FIYMYSVTESMTAGYLVVLTScefdtspkekTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMP 107
Cdd:pfam00083  28 FFKNFGLSKSVSSLAALSVLS----------GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  108 DLYSLSVI---RIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAIcsqsQGLALIYCPLVAMAilpnnFNVDLSSSYNLR 184
Cdd:pfam00083  98 GKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL----YQLAITFGILLAYI-----FGLGLNKTSNSD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  185 VWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWIcrmnrKKWEDVDITLSEEKSSTNDQEGFWKTVWY 264
Cdd:pfam00083 169 GWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKL-----RGVPDVDRELDEIKDSLEAGQEAEKASWK 243

                         250       260
                  ....*....|....*....|....*....
gi 221330798  265 EykLLFSKPHVFKFFICLFLIFGIFFTSI 293
Cdd:pfam00083 244 E--LFSTKTRRQRLLIGVMLQIFQQLTGI 270
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 45-461 3.01e-13

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 71.49  E-value: 3.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  45 VLTSCEFDT--SPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTF 122
Cdd:cd17438   21 VLPSAEKDMclSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 123 LSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFMIPGWLAL 201
Cdd:cd17438  101 IGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHyGWGFSMGTNYHFHSWRVFVIICALPCIASI 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 202 VGICLVPETPHFLMSVNRPDKALLALKWI--CRMNRKKWEDVDITLSEEKSSTNDqegFWKTVWyeykllfskphvfkff 279
Cdd:cd17438  181 IALKFMPESPRFLLEMGKHDEAWMILKNIhdTNMRAKGTPEKVFTVSNIKRKNTL---FLAVVW---------------- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 280 iclfliFGIFFTSIGLGIWFP-VIRNMDNSGSNR--------LCDLVNNNPTFINHEADDT------------------N 332
Cdd:cd17438  242 ------FTMAFSYYGLTVWFPdMIRYLQKHVTFEdslfdecyFEDVTSTDTYFKNCTIESTifyntdlyehkfidcrfiN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 333 GTDSESPK-CNDEMTNLIDPVYYGFTYIGCF------ILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIFF 405
Cdd:cd17438  316 STFLEQKEgCHMDFEEDNDFLIYLVSFLGSLsvlpgnIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQ 395

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221330798 406 VLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVT 461
Cdd:cd17438  396 CLFCGTSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILGNSIFASFVGIT 451
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 19-302 4.41e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 61.60  E-value: 4.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   19 QVIIFMVSFFIYMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALS 98
Cdd:TIGR00895  15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   99 FSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRpitvaicsqSQGLALIYCPLVAMAILPNNFNVDLS 178
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFR---------GTAVGLMFCGYPIGAAVGGFLAGWLI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  179 SSYNlrvWRFLMMF-FMIPGWLALVGICLVPETPHFLMSvNRPDKALLALKwicRMNRKKWEDVDITLSEEKSSTNDQEG 257
Cdd:TIGR00895 166 PVFG---WRSLFYVgGIAPLLLLLLLMRFLPESIDFLVS-KRPETVRRIVN---AIAPQMQAEAQSALPEQKSTQGTKRS 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 221330798  258 FwktvwyeYKLLFSKPHVfkfFICLFLIFGIFFTSIG---LGIWFPVI 302
Cdd:TIGR00895 239 V-------FKALFQGKTA---RITVLLWLLYFMLLVGvyfLTNWLPKL 276
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 45-461 1.05e-09

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 60.58  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  45 VLTSCEFDT--SPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTF 122
Cdd:cd17363   21 VLPSAEKDMclSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 123 LSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFMIPGWLAL 201
Cdd:cd17363  101 IGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHyGWGFSMGTAYQFHSWRVFVIVCALPSVASV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 202 VGICLVPETPHFLMSVNRPDKALLALKWI--CRMNRKKWEDVDITLSEEKsstNDQEGFWKTVWyeykllfskphvfkff 279
Cdd:cd17363  181 VALTFMPESPRFLLEVGKHDEAWMILKQVhdTNMRAKGHPERVFTVSHIK---RMNTLFLAIVW---------------- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 280 iclfliFGIFFTSIGLGIWFP-VIRNM-------------DNSGSNRLCDlvnnNPTFINHEADDT-------------N 332
Cdd:cd17363  242 ------FTMSFSYYGLTVWFPdMIKYLqfedslfeecyfeDVTSTNTFFE----NCTFINTVFYNTdlfeykfidsrflN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 333 GTDSESPKCNDEMTNLIDPVY--YGFTYIGCF------ILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIF 404
Cdd:cd17363  312 STFFLKEKCGCHLNDDEENAYliYLVSFLGSLsvlpgnIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGL 391

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221330798 405 FVLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVT 461
Cdd:cd17363  392 QCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGIT 448
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-212 1.75e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.22  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  21 IIFMVSFFIYMYSVTESMTAGYLVVLTScEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFS 100
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 101 VISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAmAILPNNFNvdlsss 180
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG-GLLADLFG------ 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 221330798 181 ynlrvWRFLMMFFMIPGWLALVGI-CLVPETPH 212
Cdd:COG2814  163 -----WRWVFLVNAVLALLALLLLlRLLPESRP 190
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 68-219 2.09e-09

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 59.74  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   68 GMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVI------RIIVGTFLSAVASLQVGFLGEFHAIK 141
Cdd:TIGR00887  68 GTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMatlcfwRFWLGVGIGGDYPLSAIITSEFATKK 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  142 WRPITVAICSQSQGLALIYCPLVAMAIL-----PNNFNVDLSSSYNL------RVWRFLMMFFMIPGWLALVGICLVPET 210
Cdd:TIGR00887 148 WRGAMMAAVFAMQGFGILAGAIVALIVLagfkhSLEAAADEASCTGScvpavdYMWRILIGFGAVPALLALYFRLTIPET 227


                  ....*....
gi 221330798  211 PHFLMSVNR 219
Cdd:TIGR00887 228 PRYTADVAK 236
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 23-202 2.48e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.77  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  23 FMVSFFIYMYSVTESMTAGYLVVLTSCEFD--TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFS 100
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 101 VISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPNNFNVDLsss 180
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWG--- 157

                        170       180
                 ....*....|....*....|..
gi 221330798 181 ynlrvWRFLMMFFMIPGWLALV 202
Cdd:cd17316  158 -----WRILFLIGALPALLALL 174
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 23-227 2.75e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 58.28  E-value: 2.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  23 FMVSFFIYMYSVTesmtagyLVVLTScEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVI 102
Cdd:COG0477   24 FLEGLDFTIVNVA-------LPSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 103 SALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPnnfnvdlsssyn 182
Cdd:COG0477   96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA------------ 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 221330798 183 LRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLAL 227
Cdd:COG0477  164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLL 208
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 50-220 9.34e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 57.19  E-value: 9.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  50 EFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASL 129
Cdd:cd17359   30 DFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASAL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 130 QVGFLGEFHAIKWRPITVAIcsqsQGLALIYCPLVAMAIlpnNF---NVDLSSSYNLRVWRFLMMFFMIPGWLALVGICL 206
Cdd:cd17359  110 VPMYIAEVAPAEIRGRLVSL----NQLMIVFGQLLAYIV---NYliaNAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF 182

                        170
                 ....*....|....
gi 221330798 207 VPETPHFLMSVNRP 220
Cdd:cd17359  183 IPESPRWLVSKGKP 196
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-171 1.61e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.42  E-value: 1.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  20 VIIFMVSFFIYMYSVTESMTAGYLVVltscEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSF 99
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQA----DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221330798 100 SVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN 171
Cdd:COG2271   89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 47-286 1.61e-08

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 56.81  E-value: 1.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  47 TSCEFDTSPKEKTLLANSL-LGGMVAsGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGtFLSA 125
Cdd:cd17358   32 NSLSLPLTVAQFSWFGSLLtLGALIG-ALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAG-FGGG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 126 VASLQVG-FLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAIlpnnfnvdlsssynlrVWRFLMMFFMIPGWLALVGI 204
Cdd:cd17358  110 AASVVVPvYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----------------PWRTLALIGAIPPVVFLILL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 205 CLVPETPHFLMSVNRPDKALLALKWIcrmnRKKWEDVDITLSEEKSSTNDQEGFWKTVwyEYKLLFSKPHVFKFFICLFL 284
Cdd:cd17358  174 FFIPESPRWLAKKGREEEAEKSLQFL----RGKDADISKEAAEIQEELAELEKEAKES--SFSDLFQRKYLKPLVIGLGL 247


                 ..
gi 221330798 285 IF 286
Cdd:cd17358  248 ML 249
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 45-236 3.01e-08

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 55.81  E-value: 3.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  45 VLTSCEFDT--SPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTF 122
Cdd:cd17439   21 VLPSAEKDMclSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 123 LSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFMIPGWLAL 201
Cdd:cd17439  101 IGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHyGWSFQMGSAYQFHSWRVFVLVCAFPSVFAI 180

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 221330798 202 VGICLVPETPHFLMSVNRPDKALLALKWICRMNRK 236
Cdd:cd17439  181 GALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMR 215
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-482 6.45e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.74  E-value: 6.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  22 IFMVSFFIYMysvTESMTAGYLVVLTScEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSV 101
Cdd:cd06174    1 LLLGFFLTGL---ARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 102 ISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILpnnfnvdlssSY 181
Cdd:cd06174   77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----------SS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 182 NLRVWRFLMMFFMIPGWLALVGICLVPETPHFlmsvnrpdkallalkwicrmnrkkwedvditlseeKSSTNDQEGFWKT 261
Cdd:cd06174  147 LGFGWRAVFLIAAALALLAAILLLLVVPDPPE-----------------------------------SARAKNEEASSKS 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 262 VWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGLGIWFPVIRNMdnsgsnrlcdlvnnnptfinheaddtngtdsespkC 341
Cdd:cd06174  192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG-----------------------------------L 236

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 342 NDEMTNLIDPVYYGFTYIGCFILASVLVHWMTRKYVIALHILISMILGISLNIMKQPTVVLIFFVLMMVLPGVLIPLATS 421
Cdd:cd06174  237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330798 422 VLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVTCDVTFnIFNLCLAICVVLAVF 482
Cdd:cd06174  317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG-AFLVLAVLLLLAAIL 376
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 68-236 6.92e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 51.45  E-value: 6.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  68 GMVASGLFIGFLADRYGRK--FVIRLALVGALSFsvISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPI 145
Cdd:cd17440   46 GMMVGAFFWGGLADKVGRRqsLLICMSVNGFFAF--LSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 146 TVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKAL 224
Cdd:cd17440  124 HLSWLCMFWMIGGIYASAMAWAIIPHyGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 203

                        170
                 ....*....|..
gi 221330798 225 LALKWICRMNRK 236
Cdd:cd17440  204 MILKQIHDTNMR 215
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 58-208 1.92e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 49.60  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  58 KTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEF 137
Cdd:cd17374   37 KSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEW 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330798 138 HAIKWRPITVAICSQSQGLALIYCPLVAmailpnnfnvdlsssYNLRVWRFLMMFFMIPGWLALVGICLVP 208
Cdd:cd17374  117 TTPRHRALAITLTSCFFSIGQMLLAGLA---------------YAIRDWRLLQLVVSVPFFLFFLYSWWLP 172
MFS_1 pfam07690
Major Facilitator Superfamily;
22-451 2.36e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   22 IFMVSFFIYMysvTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSV 101
Cdd:pfam07690   1 LFLAAFLAAL---GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  102 ISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAIlpnnfnvdlsssY 181
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL------------A 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  182 NLRVWRFLMMFFMIPGWLALVGICLVPETPhflmsvnrpdkallalkwicrmnrkkwedvditlseeKSSTNDQEGFWKT 261
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVLLLLPRPPP-------------------------------------ESKRPKPAEEARL 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  262 VWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGLGIWFPVIRNMdnsgsnrlcdlvnnnptfinheaddtngtdsespkc 341
Cdd:pfam07690 189 SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL------------------------------------ 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  342 nDEMTNLIDPVYYGFTYIGCFILASVLVHWM---TRKYVIALHILISMILGISLNIMKQPTVVLIFFVLMMVLPGVLIPL 418
Cdd:pfam07690 233 -SALLAGLLLGLGGLLGAIGRLLLGRLSDRLgrrRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311

                         410       420       430
                  ....*....|....*....|....*....|...
gi 221330798  419 ATSVLVDCLPVNLRGKALCMVRSLARFGGVLGS 451
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 65-228 2.39e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 49.95  E-value: 2.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  65 LLGGMVASgLFIGFLADRYGRKFVIR----LALVGALSFSV-ISALMPDLYSLSviRIIVGTFLSAVASLQVGFLGEFHA 139
Cdd:cd17357   59 FIGGAIGS-FISAFLANRFGRKNGLLisnaLLVVSSLLMFLsKSAKSPELLIFG--RFLVGIACGLSTGFVPMYLQEISP 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 140 IKWRPITVAICsqsqGLALIYCPLVAMAI-LPNNfnvdLSSSYNlrvWRFLMMFFMIPGWLALVGICLVPETPHFLMSV- 217
Cdd:cd17357  136 SELRGALGSLT----QIGVTLGILLGQVFgLPSV----LGTETL---WPYLLFFPGIPALLQLAALPFFPESPKFLLISk 204

                        170
                 ....*....|.
gi 221330798 218 NRPDKALLALK 228
Cdd:cd17357  205 GDEEEAEKSLK 215
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 65-208 2.61e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.50  E-value: 2.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  65 LLGGMVASGLFiGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVasLQVGF--LGEFHAIKW 142
Cdd:cd17317   35 FLGVLIGSLLF-GYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGI--FTVGFvlGMEIVGPKY 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330798 143 RPITVAICSQSQGLALIYCPLVAmailpnnfnvdlsssYNLRVWRFLMMFFMIPGWLALVGICLVP 208
Cdd:cd17317  112 RSFVGILFGLFWALGYMLLALLA---------------YLIRDWRWLQLAISLPGLLFLLLLWWLP 162
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 50-126 3.64e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.12  E-value: 3.64e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330798  50 EFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAV 126
Cdd:cd17365   28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 68-251 6.57e-06

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 48.33  E-value: 6.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  68 GMVASGLFIGFLADRYGRKFVIRLALVG-ALSFSVISALMpDLYSLSVIRIIVGtFLSAVASLQVG-FLGEFHAIKWRPi 145
Cdd:cd17433   53 GAAAGGVLGGWIVDRAGRKLSLMLCSVPfIAGFTVITAAQ-NVWMLYVGRLLTG-LASGVTSLVVPvYISEIAHPRVRG- 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 146 TVAICSQSQGLALIYCPLVAMAILPnnfnvdlsssynlrvWRFLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALL 225
Cdd:cd17433  130 TLGSCVQLMVVIGIMGAYLAGLVLD---------------WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMA 194

                        170       180       190
                 ....*....|....*....|....*....|
gi 221330798 226 ALKWIcRMNRKKWED----VDITLSEEKSS 251
Cdd:cd17433  195 ALRFL-RGPDQGWEWecigIEQSFHLEEQS 223
xylE PRK10077
D-xylose transporter XylE; Provisional
 61-230 7.52e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 48.15  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  61 LANSLLGGMVAS--------GLFIGFLADRYGRKFVIRLAlvgALSFsVISAL----------------MPDLYSLSVIR 116
Cdd:PRK10077  52 AANSLLGFCVASaligciigGALGGYCSNRFGRRDSLKIA---AVLF-FISALgsawpefgftsigpdnTGYVPEFVIYR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 117 IIVGTFLSAVASLQVGFLGEFHAIKWRPITVAiCSQsqgLALIYCPLVAMAIlpnNFNVDLSSS---YNLRVWRFLMMFF 193
Cdd:PRK10077 128 IIGGIGVGLASMLSPMYIAEIAPAHIRGKLVS-FNQ---FAIIFGQLVVYFV---NYFIARSGDaswLNTDGWRYMFASE 200

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 221330798 194 MIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWI 230
Cdd:PRK10077 201 AIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKI 237
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 42-217 9.47e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 47.57  E-value: 9.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  42 YLVVLTSCEFDTSpkEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGT 121
Cdd:cd17315   22 YIAKDLGFGLSTS--LQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 122 FLSAVASLQVGFLGEFHAIKWRpITVAICSQ---SQGLALIYCplvamailpnnFNVDLSSSYNLRvWRFLMMFFMIPGW 198
Cdd:cd17315  100 GVGLASVLVPLYISEIAPAKIR-GALGTLNQlmiTFGILLAYL-----------LGLALSLSPPGW-WRLMFALAAVPAL 166

                        170
                 ....*....|....*....
gi 221330798 199 LALVGICLVPETPHFLMSV 217
Cdd:cd17315  167 LQLLLMFFLPESRALLVGV 185
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 53-201 1.10e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 47.66  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  53 TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPD------LYSLSVIRIIVGTFLSAV 126
Cdd:cd17364   36 LPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGD 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221330798 127 ASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAM---AILPNNFNVDLSSSYNLrVWRFLMMFFMIPGWLAL 201
Cdd:cd17364  116 YPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLilsAIFEHPLPAGTYHHADL-VWRIVLGLGAIPALSVL 192
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 50-211 1.88e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 46.88  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  50 EFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGtFLSAVASL 129
Cdd:cd17360   29 EVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVG-LGVGIASM 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 130 QVG-FLGEFHAIKWRPITVAIcsqsQGLALIYCPLVAmailpnnFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVP 208
Cdd:cd17360  108 TVPlYIAEAAPPRIRGRLVTI----NVLFITGGQFVA-------YVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLP 176


                 ...
gi 221330798 209 ETP 211
Cdd:cd17360  177 ESP 179
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 30-217 1.88e-05

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 46.73  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  30 YMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDL 109
Cdd:cd17441    8 WMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 110 YSLSVIRIIVGTFLSAVASlQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPnnfnvdlssSYNlrvWRFL 189
Cdd:cd17441   88 SWILVLRGLVGFGIGGVPQ-SVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMP---------TLG---WRWL 154

                        170       180
                 ....*....|....*....|....*...
gi 221330798 190 MMFFMIPGWLALVGICLVPETPHFLMSV 217
Cdd:cd17441  155 LILSALPLLIFAVLCFWLPESARYWTTI 182
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 23-139 3.11e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 46.14  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  23 FMVSFFIYMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVI 102
Cdd:cd17371    1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 221330798 103 SALMPDLYSLSVIRIIVGtflsavaslqVGFLGEFHA 139
Cdd:cd17371   81 CGFAQNYWQLLILRALAG----------LGFGGEWAA 107
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 30-210 9.04e-05

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 44.83  E-value: 9.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  30 YMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDL 109
Cdd:cd17372    8 WVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 110 YSLSVIRIIVGTFLSAVASLQVGFLgEFHAIKWRPITVAICSQSQGLALIYCPLVAMAILPNnfnvdlsssynlRVWRFL 189
Cdd:cd17372   88 MWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPR------------LGWRWL 154

                        170       180
                 ....*....|....*....|.
gi 221330798 190 MMFFMIPGWLALVGICLVPET 210
Cdd:cd17372  155 LAFSSVPSSLLLVFYRWTPKT 175
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 21-136 1.01e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.46  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  21 IIFMVSFFIymySVTESMTAGYLVVLTScEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFS 100
Cdd:cd17324    3 ALALAAFAI---GTTEYVIQGLLPDIAR-DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 221330798 101 VISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGE 136
Cdd:cd17324   79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAAD 114
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-151 4.22e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   8 TALLTIGYGLGQVIIFMVSFFIYMYSVTesMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGR-- 85
Cdd:COG2271  170 LGLPGLLLALLRFWLLALAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrr 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330798  86 KFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICS 151
Cdd:COG2271  248 KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN 313
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 66-208 4.82e-04

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 42.41  E-value: 4.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  66 LGGMVASGLFiGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPI 145
Cdd:cd17447   46 AGVTMGAVAF-GYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTV 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221330798 146 TVAICSQSQGLALIYCPLVAmailpnnfnvdlsssYNLRVWRFLMMFFMIPGWLALVGICLVP 208
Cdd:cd17447  125 AGVLISLFWTVGNMLLALVA---------------YLIRDWRWLILAVTLPCAPGIITWWWVP 172
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 31-126 4.88e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  31 MYSVTESMTAGYLVVLTScEFDTSPKEKTLLANS-LLGGMVASgLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDL 109
Cdd:cd17504    7 AVMLVETMLSPALPTIQR-EFGTSAAAVSWVLTAyLLVGAVST-PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL 84

                         90
                 ....*....|....*..
gi 221330798 110 YSLSVIRIIVGTFLSAV 126
Cdd:cd17504   85 PVLIAGRALQGIGGAVF 101
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 54-177 6.28e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.79  E-value: 6.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  54 SPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVgF 133
Cdd:cd17330   32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQA-Y 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 221330798 134 LGEFHAIKWRPITVAICSQSQGLALIYCPLVAmAILPNNFNVDL 177
Cdd:cd17330  111 IADITDEEERAKAFGIISAAFGLGFILGPALG-GFLSTPYGYAL 153
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 20-208 6.53e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.79  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  20 VIIFMVSFFIYMYSvteSMTAGYLVVLTScEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSF 99
Cdd:cd17323    2 FIISFLTFVVTFGS---SIYSPALPQIAE-DFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 100 SVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLALIYCPLVAMAIlpnnfnvdlSS 179
Cdd:cd17323   78 QIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFI---------TQ 148

                        170       180
                 ....*....|....*....|....*....
gi 221330798 180 SYNlrvWRFLMMFFMIPGWLALVGICLVP 208
Cdd:cd17323  149 SLG---WRWIFWFLAIISGFCLILIFLFL 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 66-482 8.04e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.79  E-value: 8.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  66 LGGMVASgLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPI 145
Cdd:cd17325   42 LAQLLFS-PPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGR 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 146 TVAICSQSQGLALIYCPLVAMAIlpnnfnvdlsssYNLRVWRFLMMFFMIPGWLALVGICLVPEtphflmsvnrpdkall 225
Cdd:cd17325  121 AMGIFSSAIGLGFLIGPLLGGLL------------ADALGYRAPFLVCAALALLALVLALLLLP---------------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 226 alkwicrmnrkkwedvditlsEEKSSTNDQEGFWKTVWYEYKLLFSKPHVFkfficlFLIFGIFFTSIGLGIWFPVIrnm 305
Cdd:cd17325  173 ---------------------EPRPPPNKRAVSAARLRSGLRLLLRDRRLL------ALFLAIFVLAFAFGALEPFL--- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 306 dnsgSNRLCDLVNNNPTFINheaddtngtdsespkcndeMTNLIdpvyYGFTYIGCFILASVLVHWMTRKYVIALHILIS 385
Cdd:cd17325  223 ----PLYAAELGGLSPAQIG-------------------LLFGA----QGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 386 MILGISLNIMKQPTVVLIFFVLMMVLPGVLIPLATSVLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRvtcdvT 465
Cdd:cd17325  276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-----A 350

                        410
                 ....*....|....*..
gi 221330798 466 FNIFNLCLAICVVLAVF 482
Cdd:cd17325  351 FGFATPFLAAAALLLLA 367
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 37-215 8.97e-04

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 41.71  E-value: 8.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  37 SMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASgLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIR 116
Cdd:cd17435   18 GIISGALLQLRTLLALSCHEQEMVVSSLLIGALLAS-LTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 117 IIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQS--QGLALIYCPLVAMAILPNNfnvdlsssynlrvWRFLMMFFM 194
Cdd:cd17435   97 IAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMivIGILLAYISNYAFANVSNG-------------WKYMFGLVI 163

                        170       180
                 ....*....|....*....|.
gi 221330798 195 IPGWLALVGICLVPETPHFLM 215
Cdd:cd17435  164 PLAALQAIAMYFLPPSPRFLV 184
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 49-214 9.53e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 41.47  E-value: 9.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  49 CEFDTSPKEKTLLAN--SLLGGMVASGLFIG-----FLADRYGRKFVIRLALVGALSFSVIS-ALMPDLYSLSVIRIIVG 120
Cdd:cd17356   31 KYFADNTGTYYPSSSrqGLIVSIVNLGSFFGalissFLSDRIGRKKSIQIGCVIYIIGAIIQvAAIGKWYQLIVGRIIAG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 121 TFLSAVASLQVGFLGEfhaikwrpitVAICSQSQGLALIYCPLVAMAILPNNF-NVDLSSSYNLRVWRFLMMFFMIPGWL 199
Cdd:cd17356  111 LGVGFASVLVPVYQSE----------VAPKHIRGTLVSLYQLAITIGILVAYCiNYGTHKLDGSAQWRIPLGLQIVWGLL 180

                        170
                 ....*....|....*
gi 221330798 200 ALVGICLVPETPHFL 214
Cdd:cd17356  181 LLIGMFFLPESPRWL 195
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 60-215 1.10e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 41.18  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  60 LLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHA 139
Cdd:cd17379   37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVG 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221330798 140 IKWRPiTVAICSQSQ-GLALIYCPLVAMAIlPNnfnvdlsssynlrvWRFLMMFFMIPGWLALVGICLVPETPHFLM 215
Cdd:cd17379  117 SKYRR-TVGIVYQMFfTLGLLILPGIAYFI-PH--------------WRWLQLAVTLPNFLFLLYYWFIPKHTFILM 177
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-157 1.17e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  19 QVIIFMVSFFIYMYSVteSMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALS 98
Cdd:COG2814  208 RLLLLLLLAFLLGFGF--FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 221330798  99 FSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITVAICSQSQGLA 157
Cdd:COG2814  286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
42-105 1.32e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 41.16  E-value: 1.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330798  42 YLVVLTSCEFDTSPKEKTL-LANSL-LGGMVASGLFIGFLADRYGRKFVirlALVGALSFSVISAL 105
Cdd:PRK10473  22 YLVGLPRIAADLNASEAQLhIAFSVyLAGMAAAMLFAGKIADRSGRKPV---AIPGAALFIIASLL 84
PRK12307 PRK12307
MFS transporter;
30-295 1.35e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 41.07  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  30 YMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDL 109
Cdd:PRK12307  27 YVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGV 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 110 YSLSVIRIIVGtflsavaslqVGFLGEFHAIKwrpiTVAICSQSQGLAliycpLVAMAILPNNFNVDlsssyNLRVWRFL 189
Cdd:PRK12307 107 IMLTLSRFIVG----------MGMAGEYACAS----TYAVESWPKHLK-----SKASAFLVSGFGIG-----NIIAAYFM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 190 MMFFMIPGWLALVGICLVPetphflmsvnrpdkaLLALKWICRM--NRKKWEDvditlSEEKSSTNDQEGFWKTVWYEYK 267
Cdd:PRK12307 163 PSFAEAYGWRAAFFVGLLP---------------VLLVIYIRARapESKEWEE-----AKLSGKGKHSQSAWSVFSLSMK 222

                        250       260       270
                 ....*....|....*....|....*....|.
gi 221330798 268 LLFSKPHV---FKFFICLFLIFGIFFTSIGL 295
Cdd:PRK12307 223 GLFNRAQFpltLCVFIVLFSIFGANWPIFGL 253
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 50-120 1.73e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330798  50 EFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVG 120
Cdd:cd17474   28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQG 98
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 59-137 2.04e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  59 TLLANSLLGGMVASgLFIGFLADRYGRKFVIRL-ALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEF 137
Cdd:cd17477  227 LLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDR 305
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 54-131 4.78e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 4.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221330798  54 SPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIrIIVGTFLSAVASLQV 131
Cdd:cd17478  228 SLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTV 304
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 72-137 5.47e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 5.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221330798  72 SGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEF 137
Cdd:cd17473   51 FAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-129 6.40e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 6.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  20 VIIFMVSFFI-YMYSVtesmtagyLVVLTSCEFDTSPKEKTLL--ANSLLGGMVAsgLFIGFLADRYGRKFVIRLALVGA 96
Cdd:COG2223   11 TLAFFLAFGVwYLWSV--------LAPPLAEEFGLSAAQLGLLfaIPVLVGALLR--IPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 221330798  97 LSFSVISALMPDLYSLSVIRIIVG-----TFLSAVASL 129
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGiggggSFAVGIALV 118
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 18-125 6.65e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 38.90  E-value: 6.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798   18 GQVIIFMVSFFIYMYSVTESMTAGYLVVLTSCeFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLAL-VGA 96
Cdd:TIGR00710   3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAAD-LSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLfIFA 81

                          90       100
                  ....*....|....*....|....*....
gi 221330798   97 LSfSVISALMPDLYSLSVIRIIVGTFLSA 125
Cdd:TIGR00710  82 LS-SLGLALSNNIETLLVLRFVQAFGASA 109
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 67-249 8.56e-03

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 38.47  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798  67 GGMVASgLFIGFLADRYGRK----FVIRLALVGA--LSFSVISAlmpdlyslSVIRIIVGTFLSAVAS-LQVGF------ 133
Cdd:cd17431   62 GGMIGS-FSVGLFVNRFGRRnsmlYNNLLAFAGAalMGLSKLAK--------SYEMLILGRFIIGLYCgLTTGLvpmyig 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330798 134 ----------LGEFHAIKwrpITVAI-CSQSQGLALIYCplvamailpnnfnvdlsssyNLRVWRFLMMFFMIPGWLALV 202
Cdd:cd17431  133 eisptalrgaLGTLHQLG---IVVGIlISQIFGLEFILG--------------------TEELWPLLLGFTIVPAILQLA 189

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 221330798 203 GICLVPETPHFLMSV-NRPDKALLALKWIcrmnrKKWEDVDITLSEEK 249
Cdd:cd17431  190 LLPFCPESPRYLLINrNEEEEAKSVLKKL-----RGTTDVSEDIQEMK 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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