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Conserved domains on  [gi|665409727|ref|NP_995980|]
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uncharacterized protein Dmel_CG33234, isoform E [Drosophila melanogaster]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 64-234 6.97e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 98.16  E-value: 6.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:TIGR00898 137 FVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  144 VLTIMSFSLGVSMIYVPCLAgVLLPlrtepsSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRM 223
Cdd:TIGR00898 217 VGTLIQVFFSLGLVLLPLVA-YFIP------DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKI 289

                         170
                  ....*....|.
gi 665409727  224 NkGKKVTLNSL 234
Cdd:TIGR00898 290 N-GKKLPAEVL 299
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 64-234 6.97e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 98.16  E-value: 6.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:TIGR00898 137 FVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  144 VLTIMSFSLGVSMIYVPCLAgVLLPlrtepsSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRM 223
Cdd:TIGR00898 217 VGTLIQVFFSLGLVLLPLVA-YFIP------DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKI 289

                         170
                  ....*....|.
gi 665409727  224 NkGKKVTLNSL 234
Cdd:TIGR00898 290 N-GKKLPAEVL 299
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 39-224 6.91e-18

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 86.12  E-value: 6.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  39 GVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGG 118
Cdd:cd17440   19 GFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 119 FFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVPGII 189
Cdd:cd17440   99 FGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPhygwsfsmgSAYQFHSWRVFVIVCALPCVS 178

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 665409727 190 GIIILVFLPESPKYYLSINNQEKAMQVMEKICRMN 224
Cdd:cd17440  179 SVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTN 213
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 56-200 7.12e-18

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.71  E-value: 7.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:COG0477   51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLCNQVPGIIGIIILVFLPES 200
Cdd:COG0477  131 FPARERGRALGLWGAAIGLGLALGPLLGGLLVAA----LGWRWIFLINAPLGLLALVLRLRLPES 191
Sugar_tr pfam00083
Sugar (and other) transporter;
29-220 1.11e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 75.77  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   29 IWMTNEQLGFGVIIAGASCEMriHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFW 108
Cdd:pfam00083  23 LTLIDFFKNFGLSKSVSSLAA--LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKW 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  109 GFLFL---RSVGGFFI-AASVVSLMtYLSEFTKISLRPRVLTImsFSLGVSM-IYVPCLAGVLLPLRTEPSSWRILLLCN 183
Cdd:pfam00083 101 SVYQLivgRVLVGIGVgGASVLAPM-YISEIAPKKLRGALGSL--YQLAITFgILLAYIFGLGLNKTSNSDGWRIPLGLQ 177

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 665409727  184 QVPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKI 220
Cdd:pfam00083 178 LVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKL 214
xylE PRK10077
D-xylose transporter XylE; Provisional
 75-229 4.20e-08

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 55.47  E-value: 4.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  75 GELADVYGRRKIIMITStVANIVSILSACVPEF-------------WGFLFLRSVGGFFIA-ASVVSLMtYLSEFTKISL 140
Cdd:PRK10077  76 GYCSNRFGRRDSLKIAA-VLFFISALGSAWPEFgftsigpdntgyvPEFVIYRIIGGIGVGlASMLSPM-YIAEIAPAHI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 141 RPRVLTIMSFSLGVSMIYVPC------LAGVLLPLRTEpsSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAM 214
Cdd:PRK10077 154 RGKLVSFNQFAIIFGQLVVYFvnyfiaRSGDASWLNTD--GWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAE 231

                        170
                 ....*....|....*
gi 665409727 215 QVMEKICRMNKGKKV 229
Cdd:PRK10077 232 GILRKIMGNTLATQA 246
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 64-234 6.97e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 98.16  E-value: 6.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:TIGR00898 137 FVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  144 VLTIMSFSLGVSMIYVPCLAgVLLPlrtepsSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKICRM 223
Cdd:TIGR00898 217 VGTLIQVFFSLGLVLLPLVA-YFIP------DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKI 289

                         170
                  ....*....|.
gi 665409727  224 NkGKKVTLNSL 234
Cdd:TIGR00898 290 N-GKKLPAEVL 299
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 39-224 1.41e-20

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 95.04  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   39 GVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGG 118
Cdd:TIGR01299 187 GFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSG 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  119 FFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVPGII 189
Cdd:TIGR01299 267 FGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPhygwsfqmgSAYQFHSWRVFVIVCAFPCVF 346

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 665409727  190 GIIILVFLPESPKYYLSINNQEKAMQVMEKICRMN 224
Cdd:TIGR01299 347 AIGALTFMPESPRFFLENGKHDEAWMILKLIHDTN 381
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 39-224 6.91e-18

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 86.12  E-value: 6.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  39 GVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGG 118
Cdd:cd17440   19 GFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 119 FFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVPGII 189
Cdd:cd17440   99 FGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPhygwsfsmgSAYQFHSWRVFVIVCALPCVS 178

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 665409727 190 GIIILVFLPESPKYYLSINNQEKAMQVMEKICRMN 224
Cdd:cd17440  179 SVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTN 213
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 56-200 7.12e-18

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 83.71  E-value: 7.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:COG0477   51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLCNQVPGIIGIIILVFLPES 200
Cdd:COG0477  131 FPARERGRALGLWGAAIGLGLALGPLLGGLLVAA----LGWRWIFLINAPLGLLALVLRLRLPES 191
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 56-193 1.92e-17

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 83.42  E-value: 1.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd17316   38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEF 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRTEPSSWRILLLCNQVPGIIGIII 193
Cdd:cd17316  118 APSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL 175
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
56-202 1.08e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.17  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:COG2814   47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLplrtEPSSWRILLLCNQVPGIIGIIILVF-LPESPK 202
Cdd:COG2814  127 VPPERRGRALGLLGAGLGLGPALGPLLGGLLA----DLFGWRWVFLVNAVLALLALLLLLRlLPESRP 190
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 39-228 1.90e-16

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 81.61  E-value: 1.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  39 GVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGG 118
Cdd:cd17439   19 GFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 119 FFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVPGII 189
Cdd:cd17439   99 VGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPhygwsfqmgSAYQFHSWRVFVLVCAFPSVF 178

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 665409727 190 GIIILVFLPESPKYYLSINNQEKAMQVMEKICRMNKGKK 228
Cdd:cd17439  179 AIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAK 217
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 39-228 3.49e-16

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 80.61  E-value: 3.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  39 GVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGG 118
Cdd:cd17363   19 GFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 119 FFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP-------LRTEPS--SWRILLLCNQVPGII 189
Cdd:cd17363   99 IGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPhygwgfsMGTAYQfhSWRVFVIVCALPSVA 178

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 665409727 190 GIIILVFLPESPKYYLSINNQEKAMQVMEKICRMNKGKK 228
Cdd:cd17363  179 SVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAK 217
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 39-230 4.62e-16

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 80.35  E-value: 4.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  39 GVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGG 118
Cdd:cd17438   19 GFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 119 FFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLP---------LRTEPSSWRILLLCNQVPGII 189
Cdd:cd17438   99 FGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPhygwgfsmgTNYHFHSWRVFVIICALPCIA 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 665409727 190 GIIILVFLPESPKYYLSINNQEKAMQVMEKICRMNKGKKVT 230
Cdd:cd17438  179 SIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGT 219
Sugar_tr pfam00083
Sugar (and other) transporter;
29-220 1.11e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 75.77  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   29 IWMTNEQLGFGVIIAGASCEMriHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFW 108
Cdd:pfam00083  23 LTLIDFFKNFGLSKSVSSLAA--LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKW 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  109 GFLFL---RSVGGFFI-AASVVSLMtYLSEFTKISLRPRVLTImsFSLGVSM-IYVPCLAGVLLPLRTEPSSWRILLLCN 183
Cdd:pfam00083 101 SVYQLivgRVLVGIGVgGASVLAPM-YISEIAPKKLRGALGSL--YQLAITFgILLAYIFGLGLNKTSNSDGWRIPLGLQ 177

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 665409727  184 QVPGIIGIIILVFLPESPKYYLSINNQEKAMQVMEKI 220
Cdd:pfam00083 178 LVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKL 214
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 47-198 1.21e-13

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 72.18  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  47 CEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVV 126
Cdd:cd17372   27 CEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQ 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665409727 127 SLMTYLsEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPlrtePSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17372  107 LASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMP----RLGWRWLLAFSSVPSSLLLVFYRWTP 173
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 56-202 6.16e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.15  E-value: 6.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd06174   33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADL 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRTepSSWRILLLCNQVPGIIGIIILVFLPESPK 202
Cdd:cd06174  113 FPERERGRALGLLQAFGSVGGILGPLLGGILASSLG--FGWRAVFLIAAALALLAAILLLLVVPDPP 177
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
14-196 1.43e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 1.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  14 GKMQFIILLSCFNLQIWMTNEQLGFGVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTV 93
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  94 ANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtep 173
Cdd:COG2271   85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA---- 160

                        170       180
                 ....*....|....*....|...
gi 665409727 174 SSWRILLLcnqVPGIIGIIILVF 196
Cdd:COG2271  161 FGWRAAFL---ILGLPGLLLALL 180
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 30-207 5.42e-12

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 67.15  E-value: 5.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  30 WMTN--EQLGFGVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEF 107
Cdd:cd17441    8 WMADamEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 108 WGFLFLRSVGGFFIAASVVSLMTYlSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPlrtePSSWRILLLCNQVPG 187
Cdd:cd17441   88 SWILVLRGLVGFGIGGVPQSVTLY-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMP----TLGWRWLLILSALPL 162

                        170       180
                 ....*....|....*....|
gi 665409727 188 IIGIIILVFLPESPKYYLSI 207
Cdd:cd17441  163 LIFAVLCFWLPESARYWTTI 182
MFS_1 pfam07690
Major Facilitator Superfamily;
56-220 5.64e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.67  E-value: 5.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAMQ 215
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLGGLLASL----FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLS 189


                  ....*
gi 665409727  216 VMEKI 220
Cdd:pfam07690 190 LIVAW 194
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 56-220 1.08e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 66.23  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLcnqVPGIIGIIILV----FLPESPKyYLSINNQE 211
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV----FGWRSLFY---VGGIAPLLLLLllmrFLPESID-FLVSKRPE 205


                  ....*....
gi 665409727  212 KAMQVMEKI 220
Cdd:TIGR00895 206 TVRRIVNAI 214
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 58-166 1.74e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 65.29  E-value: 1.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLmTYLSEFTK 137
Cdd:cd17330   38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ-AYIADITD 116

                         90       100
                 ....*....|....*....|....*....
gi 665409727 138 ISLRPRVLTIMSFSLGVSMIYVPCLAGVL 166
Cdd:cd17330  117 EEERAKAFGIISAAFGLGFILGPALGGFL 145
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 58-201 1.75e-11

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 65.29  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTK 137
Cdd:cd17315   38 LVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAP 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 138 ISLRPRVLTIMSFSLGVSMIYVPCLAGVLlpLRTEPSSWRILLLCNQVPGIIGIIILVFLPESP 201
Cdd:cd17315  118 AKIRGALGTLNQLMITFGILLAYLLGLAL--SLSPPGWWRLMFALAAVPALLQLLLMFFLPESR 179
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 52-221 2.27e-11

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 65.82  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   52 HDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFL---RSVGGFFIAASVVSL 128
Cdd:TIGR00879  69 SSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLivgRVLLGIGVGIASALV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  129 MTYLSEFTKISLRPRVLTImsFSLGVSM-IYVPCLAGVLLPLRTEPSSWRILLLCNQVPGIIGIIILVFLPESPKYYLSI 207
Cdd:TIGR00879 149 PMYLSEIAPKALRGALTSL--YQLAITFgILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK 226

                         170
                  ....*....|....
gi 665409727  208 NNQEKAMQVMEKIC 221
Cdd:TIGR00879 227 GRVEEARKSLARLR 240
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 58-202 2.56e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.90  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTK 137
Cdd:cd17325   35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665409727 138 ISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRtepsSWRIL-LLCNQVPGIIGIIILVFLPESPK 202
Cdd:cd17325  115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----GYRAPfLVCAALALLALVLALLLLPEPRP 176
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 72-209 4.54e-11

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 64.13  E-value: 4.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  72 FLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFI-AASVVSLMtYLSEFTKISLRPRVLTI--M 148
Cdd:cd17359   54 LFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVgGASALVPM-YIAEVAPAEIRGRLVSLnqL 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665409727 149 SFSLGVSMIYVP--CLAGVLLPLRTEPSSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINN 209
Cdd:cd17359  133 MIVFGQLLAYIVnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK 195
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 18-197 8.99e-11

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 63.37  E-value: 8.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  18 FIILLSCFNLQIwmtneqlgFGVIIAGASCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIV 97
Cdd:cd17365    6 LIIVLDGFDLAV--------MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  98 SILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLTIMS--FSLGVSmiyvpcLAGVLLPLRTEPSS 175
Cdd:cd17365   78 TLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFcgYPLGAA------LGGFLAAALIPAFG 151

                        170       180
                 ....*....|....*....|..
gi 665409727 176 WRILLLcnqVPGIIGIIILVFL 197
Cdd:cd17365  152 WRSVFL---LGGVPPLILLPLL 170
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 59-203 1.61e-10

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 62.67  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  59 LMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKI 138
Cdd:cd17360   40 IVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPP 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665409727 139 SLRPRVLTIMSFSL--GVSMIYVPCLAGVLLplrtePSSWRILLLCNQVPGIIGIIILVFLPESPKY 203
Cdd:cd17360  120 RIRGRLVTINVLFItgGQFVAYVINGAFSYL-----PGGWRWMLGLAAVPAVLQFIGLLFLPESPRW 181
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 64-198 5.64e-10

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 60.67  E-value: 5.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:cd17317   35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665409727 144 VLTIMSFSLGVSMIYVPCLAGVLlplrtepSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17317  115 VGILFGLFWALGYMLLALLAYLI-------RDWRWLQLAISLPGLLFLLLLWWLP 162
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
56-203 6.18e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 60.66  E-value: 6.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 136 TKISLRPRVL--TIMSFSLGVSmiyvpcLAGVLLPLRTEPSSWRILLLcnqVPGIIGIIILV----FLPESPKY 203
Cdd:COG2223  122 FPPDRRGLALglAAGGGNLGAA------VAAFLAPLLIAAFGWRNAFL---ILGILLLVVAVlawlFLRDPPAG 186
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 65-205 1.42e-09

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 59.96  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  65 AAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFL-RSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:cd17356   56 LGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASVLVPVYQSEVAPKHIRGT 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 144 VLTIMSFS--LGVSMIYVPCLAgvlLPLRTEPSSWRILLLCNQVPGIIGIIILVFLPESPKYYL 205
Cdd:cd17356  136 LVSLYQLAitIGILVAYCINYG---THKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWLY 196
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 56-248 1.77e-09

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 59.58  E-value: 1.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAW-LMAASFA-AQMVSCFLWGELADVYGRRKIIMIT---STVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMT 130
Cdd:cd17357   49 LLWsLIVSIFFiGGAIGSFISAFLANRFGRKNGLLISnalLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPM 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 131 YLSEFTKISLRPR--VLTIMSFSLGVSMIYVPCLAGVLlplrTEPSSWRILLLCNQVPGIIGIIILVFLPESPKYYL-SI 207
Cdd:cd17357  129 YLQEISPSELRGAlgSLTQIGVTLGILLGQVFGLPSVL----GTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSK 204

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 665409727 208 NNQEKA--------------MQVMEKI----CRMNKGKKVTLNSLgvesLTQPRLRQPT 248
Cdd:cd17357  205 GDEEEAekslkflrgieddvDQELEEIkkesEQMGDQKQVSLMQL----LRDPSLRLPL 259
2_A_01_02 TIGR00880
Multidrug resistance protein;
58-200 4.82e-09

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 54.58  E-value: 4.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTK 137
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727  138 ISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLCNQVPGII-GIIILVFLPES 200
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQF----LGWRAPFLFLAILALAaFILLAFLLPET 141
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 31-215 9.12e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 57.20  E-value: 9.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  31 MTNEQLGFGVIIAGAScemrihdrrlaWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGF 110
Cdd:cd17358   29 MSDNSLSLPLTVAQFS-----------WFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWML 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 111 LFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR--VLTIMSFSLGVSMIYVpclAGVLLPlrtepssWRILLLCNQVPGI 188
Cdd:cd17358   98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAlgSLNQLLVNIGILLGYV---LGSFLP-------WRTLALIGAIPPV 167

                        170       180
                 ....*....|....*....|....*..
gi 665409727 189 IGIIILVFLPESPKYYLSINNQEKAMQ 215
Cdd:cd17358  168 VFLILLFFIPESPRWLAKKGREEEAEK 194
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 73-203 9.71e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 56.93  E-value: 9.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  73 LWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSL 152
Cdd:cd17371   53 LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGW 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665409727 153 GVSMIYVPCLAGVLLPLRTEPSSWRILLLCNQVPGIIGIIILVFLPESPKY 203
Cdd:cd17371  133 AVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQW 183
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 47-200 2.02e-08

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 55.97  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  47 CEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVV 126
Cdd:cd17442   29 CEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQ 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 127 SLMTyLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPlrtePSSWRILLLCNQVPGIIGIIILVFLPES 200
Cdd:cd17442  109 GLII-KTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIP----TLGWRWLIRFASIPGIILIVVFKFIPRT 177
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 46-202 2.65e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 55.70  E-value: 2.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  46 SCEMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASV 125
Cdd:cd17328   26 QSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 126 VSLMTYLSEFTKISLRPRVLTIMSFSlgvsmIYVPCLAGVLLP--LRTEPSSWRILLLCNQVPGII-GIIILVFLPESPK 202
Cdd:cd17328  106 PIAPTIIADLFPKEKRTRALGVFYFA-----IPLGSGLGYVVGglVAQATGGWRWAFRVTGVLGVLlAILLLLFVREPPR 180
xylE PRK10077
D-xylose transporter XylE; Provisional
 75-229 4.20e-08

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 55.47  E-value: 4.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  75 GELADVYGRRKIIMITStVANIVSILSACVPEF-------------WGFLFLRSVGGFFIA-ASVVSLMtYLSEFTKISL 140
Cdd:PRK10077  76 GYCSNRFGRRDSLKIAA-VLFFISALGSAWPEFgftsigpdntgyvPEFVIYRIIGGIGVGlASMLSPM-YIAEIAPAHI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 141 RPRVLTIMSFSLGVSMIYVPC------LAGVLLPLRTEpsSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAM 214
Cdd:PRK10077 154 RGKLVSFNQFAIIFGQLVVYFvnyfiaRSGDASWLNTD--GWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAE 231

                        170
                 ....*....|....*
gi 665409727 215 QVMEKICRMNKGKKV 229
Cdd:PRK10077 232 GILRKIMGNTLATQA 246
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 64-198 7.21e-08

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 54.22  E-value: 7.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:cd17374   45 MAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRAL 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665409727 144 VLTIMSFSLGVSMIYVPCLAGVLlplrtepSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17374  125 AITLTSCFFSIGQMLLAGLAYAI-------RDWRLLQLVVSVPFFLFFLYSWWLP 172
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 56-203 2.85e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.58  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd17320   36 VQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLplrtEPSSWRILLLcnqVPGIIGIIILV----FLPESPKY 203
Cdd:cd17320  116 YSGAELAKIFSLLMMILAIAPALAPLLGGLLL----LFFGWRAIFV---FLALLGLLLLLlvllFLPETLPE 180
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 56-203 3.02e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 52.66  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEf 135
Cdd:PRK11551  52 MGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSE- 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 136 tkiSLRPRvltimSFSLGVSMIY--VPC---LAGVLLPLRTEPSSWR-ILLLCNQVPGIIGIIILVFLPESPKY 203
Cdd:PRK11551 131 ---AVGPR-----LRGTAVSLMYcgVPFggaLASVIGVLAAGDAAWRhIFYVGGVGPLLLVPLLMRWLPESRAF 196
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 64-199 4.06e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 51.81  E-value: 4.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:cd17323   44 VLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGK 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 665409727 144 VLTIMSFSLGVSMIYVPCLAGVLlplrTEPSSWR---ILLLCnqVPGIIGIIILVFLPE 199
Cdd:cd17323  124 AMGVYSLGPLLGPALGPIIGGFI----TQSLGWRwifWFLAI--ISGFCLILIFLFLPI 176
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
57-156 1.24e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.36  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFT 136
Cdd:COG2814  246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325

                         90       100
                 ....*....|....*....|
gi 665409727 137 KISLRPRVLTIMSFSLGVSM 156
Cdd:COG2814  326 PPEARGRASGLYNSAFFLGG 345
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 58-197 1.51e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTK 137
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 138 ISLRPRVLTIMSFSLGVSMIYVPCLAGVLlplrTEPSSWRILLLCNQVPGIIGIIILVFL 197
Cdd:cd17325  319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFL----YDAFGFATPFLAAAALLLLAAVLFLLL 374
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 68-220 1.55e-06

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 50.41  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  68 MVSCFLWGELADVYGRRKIIMitstVANIVSILSAC------VPEFWGFLFL-RSVGGFFIAASVVSLMTYLSEFTKISL 140
Cdd:cd17431   64 MIGSFSVGLFVNRFGRRNSML----YNNLLAFAGAAlmglskLAKSYEMLILgRFIIGLYCGLTTGLVPMYIGEISPTAL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 141 RPRVLTImsFSLGVSM-IYVPCLAGVLLPLRTEpSSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQE-KAMQVME 218
Cdd:cd17431  140 RGALGTL--HQLGIVVgILISQIFGLEFILGTE-ELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEeEAKSVLK 216


                 ..
gi 665409727 219 KI 220
Cdd:cd17431  217 KL 218
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
57-198 1.92e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRK--IIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSE 134
Cdd:COG2271  219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 135 FTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLplrtEPSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:COG2271  299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLL----DATGYQAAFLLLAALALLAALLALLLL 358
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 77-218 1.97e-06

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 49.83  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  77 LADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLR------PRVLTImsf 150
Cdd:cd17434   64 LNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRgalgacPQIMAV--- 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665409727 151 sLGVSMIYVpclAGVLLPlrtepssWRILLLCNQVPGIIGIIILVFLPESPKYYLSINNQEKAMQVME 218
Cdd:cd17434  141 -FGSLALYA---LGLLLP-------WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALA 197
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 57-197 2.49e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.47  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFT 136
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665409727 137 KISLRPRVLTIMSFSLGVSMIyvpcLAGVLLPLRTEPSSWRILLLCNQVPGIIGIIILVFL 197
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLV----LGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 56-198 9.21e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.55  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAA---SFAAQMVscfLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYL 132
Cdd:cd17321   33 LQWVVNAyllAFAALLL---LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALI 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665409727 133 SEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLcnqVPGIIGIIILVFLP 198
Cdd:cd17321  110 AATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL----FGWRWIFL---INVPIGLVALLLAR 168
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 56-197 2.41e-05

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 46.43  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVS-ILSACVPEF-----WGFLFLRSVGGFfiAASVVSLM 129
Cdd:cd17326   38 FGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGnILYALAEYFpsnrkYVMLVARFLIGV--GAGNVAVL 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665409727 130 -TYLSEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRTEPSSWRILLLCNQ---------VPGIIGIIILVFL 197
Cdd:cd17326  116 rAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPGYVIGIKLRFNMytapawlmaILGIINIILILFF 193
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 57-197 2.51e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.41  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELAD---VYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLS 133
Cdd:cd17319  218 GLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPA 297

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 134 EFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLplrTEPSSWRILLLCNQVPGIIGIIILVFL 197
Cdd:cd17319  298 DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV---DATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 56-203 2.83e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 46.11  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd17312   40 LGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNW 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepSSWRILLLcnqVPGII----GIIILVFLPESPKY 203
Cdd:cd17312  120 FSKKERGTVYGIWSTSHNFGGILAPILAASLASY----YGWRAAFL---VPGIVglvvAIILFFFLRDSPPY 184
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 75-209 4.07e-05

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 45.56  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  75 GELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLtimsfSLGV 154
Cdd:cd17435   57 GVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLV-----SLNE 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665409727 155 SMIYVPCLAGVLL--PLRTEPSSWRILLLCNQVPGIIGIIILVFLPESPKYYLSINN 209
Cdd:cd17435  132 LMIVIGILLAYISnyAFANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDN 188
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 64-198 5.57e-05

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 45.11  E-value: 5.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPR 143
Cdd:cd17447   45 FAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTV 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665409727 144 VLTIMSFSLGVSMIYVPCLAGVLlplrtepSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17447  125 AGVLISLFWTVGNMLLALVAYLI-------RDWRWLILAVTLPCAPGIITWWWVP 172
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 56-198 5.82e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 45.25  E-value: 5.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd17502   32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLlplrTEPSSWRILLLCNqVPgiIGIIILVFLP 198
Cdd:cd17502  112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAF----TDHLSWRWCFYIN-LP--IGGLALALLR 167
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 64-198 5.84e-05

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 45.04  E-value: 5.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  64 FAAQMVSCFLWGELADVYGRRKIIMITSTVAN-IVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRP 142
Cdd:cd17378   43 FVGCLIGSGVLGHLADSSLGRKNLLFLSCLLMaLSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRG 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665409727 143 RVlTIMSFSLGVSMIYVPCLAGVLlplrtEPSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17378  123 QV-GMSTFFFFVLGFMSLPGIAYL-----NGSSWRVLYFWTSIPALIYCILVYLFA 172
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 64-198 8.44e-05

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 44.76  E-value: 8.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  64 FAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRpr 143
Cdd:cd17376   45 FVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVR-- 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665409727 144 vltIMSFSLGVSMIYvpCLAGVLLPLRTEP-SSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17376  123 ---ILFSTLGVCIFY--AIGYMLLPLFAYFiRDWRMLLLALTLPGVLCVPLWWFIP 173
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 57-129 9.03e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 44.50  E-value: 9.03e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPE--FWGFLFLRSVGGFFIAAsVVSLM 129
Cdd:cd17335   35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAqiFWLLLLLVILGAFFSAP-VVPLV 108
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 31-203 9.08e-05

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 44.70  E-value: 9.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  31 MTNEQLGFGV-IIAGASC----EMRIHDRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVP 105
Cdd:cd17437    4 LNSILLGYDIgVMSGAVIfikeDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 106 EFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLTI--MSFSLGVSMIYVPCLAGVLLPLRTepsSWRILLLCN 183
Cdd:cd17437   84 NYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFpeIFINIGILLGYVSNYAFSGLPLHV---GWRLMLGVG 160

                        170       180
                 ....*....|....*....|
gi 665409727 184 QVPGIIGIIILVFLPESPKY 203
Cdd:cd17437  161 AVPSLFLAIGVLAMPESPRW 180
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 77-198 1.08e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.49  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  77 LADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSLGVSM 156
Cdd:cd17503   54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 665409727 157 IYVPCLAGVLlplrTEPSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17503  134 AIGPTLGGWL----TDNLSWRWIFYINLPIGILALLLAPLLD 171
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 57-193 1.79e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.72  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFT 136
Cdd:cd17504   34 SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFP 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665409727 137 KiSLRPRVLTIMSFSLGVSMIYVPCLAGVLlplrTEPSSWRILLLCNQVPGIIGIII 193
Cdd:cd17504  114 P-ERVPVAQGILSATFGIGAGIGLPLGGWI----VQHLGWRWIFWTAAPVAVLLAAL 165
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
56-213 2.19e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPE--FWGFLFLRSVGGFFIAASVVSLMTYLS 133
Cdd:COG2211  266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLA 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 134 E-------FTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPL--------RTEPSSWRILLLCNQVPGI---IGIIILV 195
Cdd:COG2211  346 DvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALfgyvagaaQSPSALTGIRLLFFLLPAVlllLAALLLL 425

                        170
                 ....*....|....*...
gi 665409727 196 FLPESPKYYLSINNQEKA 213
Cdd:COG2211  426 FYPLTRERHAEIRAELAA 443
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 75-198 2.99e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 42.72  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  75 GELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRV--LTIMSFSL 152
Cdd:cd17379   54 GYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVgiVYQMFFTL 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 665409727 153 GVsmIYVPCLAGVLlplrtepSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:cd17379  134 GL--LILPGIAYFI-------PHWRWLQLAVTLPNFLFLLYYWFIP 170
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 75-217 3.02e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 42.99  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  75 GELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLrSVGGFF------IAASVVSLmtYLSEFTKISLRPRVLTIM 148
Cdd:cd17432   71 GPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFEMI-IVGRFLvginagISLNVVPM--YLGESAPKNLRGAVGLVP 147

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665409727 149 SfslgvSMIYVPCLAGVLLPLRT---EPSSWRILLLCNQVPGIIGIIILVFLPESPKYYL-SINNQEKAMQVM 217
Cdd:cd17432  148 A-----IFITLGILLGQVLGLREllgNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLiEKGDEEAARKAL 215
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 58-195 3.05e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPE--FWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd17316  217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSgsPTLLLLLLFILSFFVGGVWGALYAYLAEL 296

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRTEPSSWRILLLCnqvPGIIGIIILV 195
Cdd:cd17316  297 FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL---LAIVALIVAL 353
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 57-202 3.81e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFT 136
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665409727 137 KISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLrtepsSWRILLLCNQVPGIIGIIILVFLPESPK 202
Cdd:cd17474  117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-----SWRYPFFLLAALIPVAFLAILFLLPEPK 177
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 59-137 3.93e-04

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 42.62  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   59 LMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSA-CVP---EFWGFLFLRSVGGFFIAASV----VSLMT 130
Cdd:pfam12832  39 ITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVlFIPislTFWWLALLVVLFSFFWNAILpqfeVATLQ 118


                  ....*..
gi 665409727  131 YLSEFTK 137
Cdd:pfam12832 119 HLGEKRK 125
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 56-197 4.39e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.60  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd06173  246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIyvpcLAGVLLPLRTEPSSWRILLLcnqVPGIIGIIILVFL 197
Cdd:cd06173  326 VPDELRGRVFSVYNALNSGAMP----LGALLAGLLADALGLSAVFL---LAGALLLLAALLL 380
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 53-201 5.22e-04

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 42.24  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  53 DRRLAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYL 132
Cdd:cd17361   50 DQLLQLFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYL 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665409727 133 SEFTKISLRPRVltIMSFSLGVSMiyvPCLAGVLLPLRTE---PSSWRILLLCNQVPGIIGIIILVFLPESP 201
Cdd:cd17361  130 SEMAPAKLRGAL--NIGFQLAITI---GILIANLINYGTSkikPNGWRLSLGLAAVPALILLLGSLFLPETP 196
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
56-198 5.81e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 5.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:COG0738   45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665409727 136 TKISlRPRVLTIMSFSLGVSMIYVPCLAGVLLpLRTEPSSWRILLLCNQVPGIIGIIILVFLP 198
Cdd:COG0738  125 GPET-AASRLNLLHAFFSLGALLGPLLGGLLI-LLGLSLSWHLPYLILAVLLLLLALLFLRSK 185
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 57-200 8.32e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.61  E-value: 8.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGrRKIIMITSTVA-NIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:PRK03893  58 ASLISAAFISRWFGGLLLGAMGDRYG-RRLAMVISIVLfSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIES 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665409727 136 TKISLRPRV--LTIMSFSLGVsmiyvpCLAGVLLPLRTEPSSWRILLLCNQVPGIIGIIILVFLPES 200
Cdd:PRK03893 137 WPKHLRNKAsgFLISGFSIGA------VVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEA 197
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 72-219 1.27e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 41.25  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   72 FLWGELADVYGRRK------IIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLR---- 141
Cdd:TIGR00887  74 LFFGWLADKLGRKRvygmelIIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRgamm 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  142 PRVLTIMSFS-LGVSMIYVPCLAGVLLPLRTEPSS--------------WRILLLCNQVPGIIGIIILVFLPESPKYYLS 206
Cdd:TIGR00887 154 AAVFAMQGFGiLAGAIVALIVLAGFKHSLEAAADEasctgscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTAD 233

                         170
                  ....*....|....
gi 665409727  207 IN-NQEKAMQVMEK 219
Cdd:TIGR00887 234 VAkDVEQAASDMSA 247
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 58-198 1.38e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.62  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  58 WLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTK 137
Cdd:cd17477   35 LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665409727 138 ISLRPRVLTIMSFSLGVSMIyvpcLAGVLLPLrTEPSSWRILLLCnqvpgiIGIIILVFLP 198
Cdd:cd17477  115 NENRGRVLGLYSTVLGLGFA----LGPLLLAL-VGTAGALPFLIA------AVLLLLALVP 164
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 73-120 1.63e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 665409727  73 LWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFF 120
Cdd:cd17391   55 IWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVF 102
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 75-203 1.71e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 40.41  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  75 GELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLtimsfSLGV 154
Cdd:cd17362   60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLV-----SLKE 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665409727 155 SMIYVPCLAGVLLP--LRTEPSSWRILLLCNQVPGIIGIIILVFLPESPKY 203
Cdd:cd17362  135 LFIVLGILLGYVSGyaFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 60-167 1.83e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  60 MAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKIS 139
Cdd:cd17391  246 FSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKE 325

                         90       100
                 ....*....|....*....|....*...
gi 665409727 140 LRPRVltimsFSLGVSMIYVPCLAGVLL 167
Cdd:cd17391  326 VAGRI-----FGYNQSFQYLGNVAGPLL 348
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 57-166 1.99e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.31  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGfFIAASVVSLMTYLSEFT 136
Cdd:cd17388   41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAG-ITGATGAVAAAYIADVT 119

                         90       100       110
                 ....*....|....*....|....*....|
gi 665409727 137 KISLRPRVLTIMSFSLGVSMIYVPCLAGVL 166
Cdd:cd17388  120 PPEQRARNFGLLGAAFGLGFIAGPALGGLL 149
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
73-200 2.06e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 40.28  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  73 LWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVV---SLMTYL---SEFTKislrprvlt 146
Cdd:PRK11102  45 FYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVvinALMRDMfpkEEFSR--------- 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665409727 147 IMSFSLGVSMI---YVPCLAGVLLPLrtepSSWRILLLCNQVPGIIGII-ILVFLPES 200
Cdd:PRK11102 116 MMSFVTLVMTIaplLAPIIGGWLLVW----FSWHAIFWVLALAAILAAAlVFFFIPET 169
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 57-177 3.16e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.92  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGffIAASVVSLMTY-LSEF 135
Cdd:cd06179   35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIG--IGAGTQGLGAAvASEL 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLlpLRTEPSSWR 177
Cdd:cd06179  113 VPNKYRGLVQGVVNLVASPGSALGPLIAGAL--VEANAAGWR 152
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
57-202 3.49e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFA-AQMVSCFLWGELADVYGRRKIIMITSTVANIVSI-LSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSE 134
Cdd:COG2223  243 AGLLAALFAlLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLlLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665409727 135 FTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRtepSSWRILLLCNQVPGIIGIIILVFLPESPK 202
Cdd:COG2223  323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT---GSYTAAFLVFAVLALVALVLTLLLYRRPR 387
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 56-198 3.62e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  56 LAWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEF 135
Cdd:cd17319   40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEW 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409727 136 TKISLRPRVLTIMSFSLGVSMIYVPCLAGVLLPLRtepsSWRILLLCNQVPGII-GIIILVFLP 198
Cdd:cd17319  120 FPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF----GWRWAFIIEGLLGLLlAVLWWFYLR 179
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 73-168 4.00e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 39.29  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727   73 LWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKISLRPRVLTIMSFSL 152
Cdd:TIGR00710  59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVL 138

                          90
                  ....*....|....*.
gi 665409727  153 GVSMIYVPCLAGVLLP 168
Cdd:TIGR00710 139 ALAPAVAPLLGGYILV 154
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 61-203 5.89e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.82  E-value: 5.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  61 AASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEF-----WGFLFLR--------SVGGFFIAASvvs 127
Cdd:cd17367   47 AVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiWAPIILLlarllqglSVGGEYGTSA--- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727 128 lmTYLSEFTKISLRPRVLTIMSFSL--------GVSMIyvpcLAGVLLPLRTEPSSWRILLLCNQVPGIIGIIILVFLPE 199
Cdd:cd17367  124 --TYLSEVAPPGRRGFYSSFQYVTLiggqllalGVLLV----LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEE 197


                 ....
gi 665409727 200 SPKY 203
Cdd:cd17367  198 TESF 201
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 59-166 8.92e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.34  E-value: 8.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  59 LMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILSACVPEFWGFLFLRSVGGFFIAASVVSLMTYLSEFTKI 138
Cdd:cd17489   36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                         90       100
                 ....*....|....*....|....*...
gi 665409727 139 SLRPRVLTIMSFSLGVSMIYVPCLAGVL 166
Cdd:cd17489  116 SRRGEGIGYYGLATTLAMALGPALGLFL 143
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 57-167 9.95e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 37.92  E-value: 9.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409727  57 AWLMAASFAAQMVSCFLWGELADVYGRRKIIMITSTVANIVSILsacVPEFWGFLFLRSVGGFFIAASVVSL----MTYL 132
Cdd:cd17477  226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALL---LPLVPGLPLALLVLLFLWGGAAGPLytlaLALA 302

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665409727 133 SEFTKISLRPRVLTIMSFSLGVSMIYVPCLAGVLL 167
Cdd:cd17477  303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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