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Conserved domains on  [gi|45580810|ref|NP_996246|]
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Fancd2 [Drosophila melanogaster]

Protein Classification

FANCI/FANCD2 family protein( domain architecture ID 98588)

FANCI/FANCD2 family protein similar to Homo sapiens fanconi anemia group I protein (FANCI) and fanconi anemia group D2 protein (FANCD2)

Gene Ontology:  GO:0006281|GO:0070182

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FANC super family cl17018
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 132-1422 0e+00

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


The actual alignment was detected with superfamily member cd11721:

Pssm-ID: 473054  Cd Length: 1161  Bit Score: 733.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  132 DKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQIYQSQNSMFMNFLMIDFMRDACVEVLLNKIEEVAKSDRVimgk 211
Cdd:cd11721    2 ENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEDAS---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  212 AAIPLPLLPLMLTQLRYLT-ASHKVEIYSRIEVIFNRATESAKLDIIANAELILDASMHDEFVELLNINYSStEDLFHMT 290
Cdd:cd11721   78 VPSEDNLPRLILNQFKWLDhIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQE-NSELTVP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  291 TVQTLGNLSLSDRTQAKLRVRILDFATSGQCSDaiLPHLIRLLLNVLkidTDDSVRDLIGSLRGIFNWRHTNETE----K 366
Cdd:cd11721  157 ILDALSNLNLSPELLSEIREKVLSCLKTVPLED--LPVLVKFLLQSI---TATEALEIISKLRKNLDFSPLSDPSssgsS 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  367 ISASEDSKKSQLELFGFLELGLIRSKKFYQACQRSSASVPAAEF-TSFDMILLLLLIHVNEDNSLYIENILRRRIKLEHI 445
Cdd:cd11721  232 DKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDhKVIDLILLLILYSTNEDKRKSIESLLKKKIKSGFI 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  446 TVSILEEIRQHYRHILEQHITTLMNILHDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSPHLTTm 524
Cdd:cd11721  312 RTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRyYQQEVVGALITHIGSGNSSEVDA- 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  525 ALELLRELQRKSAKDVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAFPDPNLSPCLQLQEQVDMVVKKQLINSIDNI 604
Cdd:cd11721  391 ALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPLSEGSSIQDDLHIIVRKQLSNSSPKY 470

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  605 KKQGIIGCVQLIDAMARIANNGvdrDEFIASVENVDSLPDGRGKMAANLIIRTEASIGNSTESLALFFEELATVFNQRne 684
Cdd:cd11721  471 KRMGIIGAVTLVKHLASANSSD---DAVERSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQA-- 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  685 gtsgCELDNQFIAWACDLVTFRFQASFVTENVPEtlkgikleyqlninelddtdantesdvlniginisklvlspkvkac 764
Cdd:cd11721  546 ----SNLDPKFLEWLGETITEDFQESFVVDLDET---------------------------------------------- 575

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  765 dSIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPSFFeddnYVSVFENFEAEQQKDILSIYFHTVNWMRVSISAF 844
Cdd:cd11721  576 -SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFE----VDEKFDSLSTEQRSVVLDCLFYAINWFREVINAF 650

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  845 ASQRDPPTRRRVLSRLGELIRIEQRMKPLLARApvdfvappyqfltnvklsnqnqkrpgpkpaaklnatlpepdltgnqp 924
Cdd:cd11721  651 ATQKDASTKKKVLKRLRNLIELEGRLSKLLAHC----------------------------------------------- 683

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  925 siadftikvgqcktvktktdfeqmygpreRYRPMEVEIIMLLVEQKFVLNHQLEEEQMGEFLGLLELRFLLEDVVQKLEA 1004
Cdd:cd11721  684 -----------------------------YFRELDLEVFSLLKSGLVTDTSLELSEEEGVHLGPKELRFLLEDLNRKLEH 734

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1005 AVLRHHDSydADSFRPHLAKPEDFICDLLPCLHEVNNHLITLGEAIDNQLTEVSHVYSNLD-----------LFKDQFCY 1073
Cdd:cd11721  735 VLTSPKKK--RMPLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLlsnagqldapgPFVQENQY 812

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1074 IKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQPKTQWKRLEKQSVPQLANLTFQYFLKYEKSVLNLSTAVHLHR 1153
Cdd:cd11721  813 AKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKDLPLKELVSSLFKYLKSFEPSVPSLSTAVSLVQ 892

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1154 LLCNLLKLgslqsdaSQPRFQQAEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFLKKSNAKSQTELLTELVK 1233
Cdd:cd11721  893 LLQALMEK-------SPDRPQLREKLADLARNFLCRQWPDLSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKLEEIAGEA 965

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1234 QCSILNTKDK--ALTSFPNFKKANFPLLFRGLCEVLIHSLSGQVSVDSRG-----DKLKLWESAVDLLNGLLSIVQQVEQ 1306
Cdd:cd11721  966 LPELLEKKKDkdALETFPTLSKSTFPIFFRVLMEALIESVKKILSSAADTgggemERLLLWQSAVRVFKALVNLVKTFDK 1045

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1307 PRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTRFLHQLCCHSKSIKNTAIISYIPSLRETIETL 1386
Cdd:cd11721 1046 RPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPALKKSLETL 1125

                       1290      1300      1310
                 ....*....|....*....|....*....|....*.
gi 45580810 1387 VFRVKALLAANNCHSAFHMGNMINRDLHGDSIITPR 1422
Cdd:cd11721 1126 VYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
 
Name Accession Description Interval E-value
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 132-1422 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 733.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  132 DKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQIYQSQNSMFMNFLMIDFMRDACVEVLLNKIEEVAKSDRVimgk 211
Cdd:cd11721    2 ENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEDAS---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  212 AAIPLPLLPLMLTQLRYLT-ASHKVEIYSRIEVIFNRATESAKLDIIANAELILDASMHDEFVELLNINYSStEDLFHMT 290
Cdd:cd11721   78 VPSEDNLPRLILNQFKWLDhIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQE-NSELTVP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  291 TVQTLGNLSLSDRTQAKLRVRILDFATSGQCSDaiLPHLIRLLLNVLkidTDDSVRDLIGSLRGIFNWRHTNETE----K 366
Cdd:cd11721  157 ILDALSNLNLSPELLSEIREKVLSCLKTVPLED--LPVLVKFLLQSI---TATEALEIISKLRKNLDFSPLSDPSssgsS 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  367 ISASEDSKKSQLELFGFLELGLIRSKKFYQACQRSSASVPAAEF-TSFDMILLLLLIHVNEDNSLYIENILRRRIKLEHI 445
Cdd:cd11721  232 DKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDhKVIDLILLLILYSTNEDKRKSIESLLKKKIKSGFI 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  446 TVSILEEIRQHYRHILEQHITTLMNILHDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSPHLTTm 524
Cdd:cd11721  312 RTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRyYQQEVVGALITHIGSGNSSEVDA- 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  525 ALELLRELQRKSAKDVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAFPDPNLSPCLQLQEQVDMVVKKQLINSIDNI 604
Cdd:cd11721  391 ALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPLSEGSSIQDDLHIIVRKQLSNSSPKY 470

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  605 KKQGIIGCVQLIDAMARIANNGvdrDEFIASVENVDSLPDGRGKMAANLIIRTEASIGNSTESLALFFEELATVFNQRne 684
Cdd:cd11721  471 KRMGIIGAVTLVKHLASANSSD---DAVERSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQA-- 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  685 gtsgCELDNQFIAWACDLVTFRFQASFVTENVPEtlkgikleyqlninelddtdantesdvlniginisklvlspkvkac 764
Cdd:cd11721  546 ----SNLDPKFLEWLGETITEDFQESFVVDLDET---------------------------------------------- 575

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  765 dSIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPSFFeddnYVSVFENFEAEQQKDILSIYFHTVNWMRVSISAF 844
Cdd:cd11721  576 -SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFE----VDEKFDSLSTEQRSVVLDCLFYAINWFREVINAF 650

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  845 ASQRDPPTRRRVLSRLGELIRIEQRMKPLLARApvdfvappyqfltnvklsnqnqkrpgpkpaaklnatlpepdltgnqp 924
Cdd:cd11721  651 ATQKDASTKKKVLKRLRNLIELEGRLSKLLAHC----------------------------------------------- 683

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  925 siadftikvgqcktvktktdfeqmygpreRYRPMEVEIIMLLVEQKFVLNHQLEEEQMGEFLGLLELRFLLEDVVQKLEA 1004
Cdd:cd11721  684 -----------------------------YFRELDLEVFSLLKSGLVTDTSLELSEEEGVHLGPKELRFLLEDLNRKLEH 734

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1005 AVLRHHDSydADSFRPHLAKPEDFICDLLPCLHEVNNHLITLGEAIDNQLTEVSHVYSNLD-----------LFKDQFCY 1073
Cdd:cd11721  735 VLTSPKKK--RMPLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLlsnagqldapgPFVQENQY 812

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1074 IKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQPKTQWKRLEKQSVPQLANLTFQYFLKYEKSVLNLSTAVHLHR 1153
Cdd:cd11721  813 AKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKDLPLKELVSSLFKYLKSFEPSVPSLSTAVSLVQ 892

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1154 LLCNLLKLgslqsdaSQPRFQQAEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFLKKSNAKSQTELLTELVK 1233
Cdd:cd11721  893 LLQALMEK-------SPDRPQLREKLADLARNFLCRQWPDLSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKLEEIAGEA 965

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1234 QCSILNTKDK--ALTSFPNFKKANFPLLFRGLCEVLIHSLSGQVSVDSRG-----DKLKLWESAVDLLNGLLSIVQQVEQ 1306
Cdd:cd11721  966 LPELLEKKKDkdALETFPTLSKSTFPIFFRVLMEALIESVKKILSSAADTgggemERLLLWQSAVRVFKALVNLVKTFDK 1045

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1307 PRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTRFLHQLCCHSKSIKNTAIISYIPSLRETIETL 1386
Cdd:cd11721 1046 RPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPALKKSLETL 1125

                       1290      1300      1310
                 ....*....|....*....|....*....|....*.
gi 45580810 1387 VFRVKALLAANNCHSAFHMGNMINRDLHGDSIITPR 1422
Cdd:cd11721 1126 VYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 90-1434 2.30e-71

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 263.55  E-value: 2.30e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810     90 FELVLVRAGVQLDQGDSL-ILACDHVPIVSKLREIFTSASSYTDKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQ 168
Cdd:pfam14631   14 FVKLLKTAGVILKTGENQnEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCLLPCVPLQSEEASS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    169 IYQS-QNSMFMNFLMIDFMRDACVEVLLNKIEEV----AKSDRVIMGKAAIplpllplmlTQLRYLT-ASHKVEIYSRIE 242
Cdd:pfam14631   94 MVTSyQESLIKLLLGIEILQPAIIKTLFEKLPEFmfesVNSDGLNMPRLII---------NQLKWLDrIVDGKDLTSKLM 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    243 VIFNRATESAKLDIIANAELILDASMHD----EFVELLNINYSSTedlfhMTTVQTLGNLSLSDRTQAKLRVRILDFATS 318
Cdd:pfam14631  165 QLISVAPVELQHDIITSLPEILEDSQHNdvarELSSLLVENTQLT-----VPILDALSSLNLDPTLLSEVRQAVMGTLSA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    319 GQCSDaiLPHLIRLLLNVLkidTDDSVRDLIGSLRGIFNWRHTNETEKISASEDSKKSQLELFG------------FLEL 386
Cdd:pfam14631  240 VQLED--LPVVVKFILHSV---SATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSsgnqasssqdciSLVF 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    387 GLIRSKKFYQACQrSSASVPAAEFT-------SFDMILLLLLIHVNEDNSLYIENILRRRIKLEHITVSILEEIRQHYRH 459
Cdd:pfam14631  315 DVIKSAVRFQKTI-SEAWLKAIENIdsvsdhkVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHAL 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    460 ILEQHITTLMNILHDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSpHLTTMALELLRELQRKSAK 538
Cdd:pfam14631  394 VLRDYFPSILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSyCQQEVVGALVTHVCSGNE-AEVDVALELLLELVVLKPS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    539 DVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAFPDPNLSPClQLQEQVDMVVKKQLINSIDNIKKQGIIGCVQLIDA 618
Cdd:pfam14631  473 AMRLYAVFVKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSS-HIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGS 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    619 MArianngVDRDEFIASVENVdSLPDGRGKMAANLIIRTEASIGNSTESLALFFEELATVFNQRNegtsgceLDNQFIAW 698
Cdd:pfam14631  552 MA------ADRSKSGSSSQSA-SLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGK-------LDPKVLEW 617

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    699 ACDLVTFRFQASFVTENVPET----LKGIKLEYQLNINELDDTdantesdvlnIGINISKLVLSPKVKACD--------- 765
Cdd:pfam14631  618 IGQSVLNDFQDDFVVDLGPDIegdfPFPVKALYGLEEEESQGG----------IAINLLPLLAKDEQAKDEgevtaqekg 687

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    766 ----SIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPsffeDDNYVSVFENFEAEQQKDILSIYFHTVNWMRVSI 841
Cdd:pfam14631  688 qkrvSPLCLSPFFRLLRLCVEKQHDGDLEEIDGLLGCPLILT----DLEVGEKLESLSKKEREFLCSLLFHTINWFREVV 763

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    842 SAFASQRDPPTRRRVLSRLGELIRIEQRMKPLLARAPvDFVAPpyqfLTNVKLSNQNQKRPGpkpaaklnatlpEPDLTG 921
Cdd:pfam14631  764 NAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVTP-GYVPP----LANFDLDSSQKEEAS------------EAEESQ 826

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    922 NQPSIADFTIKVGQCKTVKTKTDFeqmygpRERYRPMEVEIIMLL---VEQKFVLNHQL-----EEEQMGEFLGLLELRf 993
Cdd:pfam14631  827 SEKSQLEKEFKGKEGKTGVSLQSY------RAFFRELDIEVFSVLhcgLLTKSLLDTEMhtkarEEVQLGPAELLFLLE- 899

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    994 lleDVVQKLE----------AAVLRHHDSYDADSFRPHLAKPEDFI---CDLLP--CLHEVN--NHLITLgeaidnqLTE 1056
Cdd:pfam14631  900 ---DLSRKLEfmltpapakrAPFLKGKGDRNVGFSHLQQRSAQEIAhcvVQLLPplCNHLENihNYFQCL-------LAE 969

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1057 VSHVYSNLDLFKDQFCYIKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQPKTQWKRLEkQSVPQLANLTFQYFL 1136
Cdd:pfam14631  970 NHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLFAWSGFSQPENRSLLKSALGVLAGRLKEGEAE-LTLEELVSHSFEYLQ 1048

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1137 KYEKSVLNLSTAVHLHRLLCNLLKLGSlqsDASQPRfqqaEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFL 1216
Cdd:pfam14631 1049 NFRSSVPSFQCALCLIQLLIVIAEKSG---NPAAKR----EKIASLARQFLCQVWVTPSGEKEKGNKFNDALHTLLCIYL 1121

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1217 KKSNA--KSQTELLTELVKQCsILNTKDKALTSFPNFKKANFPLLFRGL---CEVLIHSLSGQVSVDSR---GDKLKLWE 1288
Cdd:pfam14631 1122 EHTDDvlKAIEEIAGEGVPEL-INSSKDASSSTFPTLTRQTFLVFFRVMmaeLEKSVRKIQPGTASDSQevqEEKLLYWN 1200

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1289 SAVDLLNGLLSIVQQVEQPRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTRFLHQLCCHSKSIK 1368
Cdd:pfam14631 1201 MAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMPLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQ 1280

                         1370      1380      1390      1400      1410      1420
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45580810   1369 NTAIISYIPSLRETIETLVFRVKALLAANNCHSAFHMGNMINRDLHGDSIITPRSSFAGEENSDDE 1434
Cdd:pfam14631 1281 DTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKNRDLQGEEILSQRSQESDEEEEEDS 1346
 
Name Accession Description Interval E-value
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 132-1422 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 733.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  132 DKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQIYQSQNSMFMNFLMIDFMRDACVEVLLNKIEEVAKSDRVimgk 211
Cdd:cd11721    2 ENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEDAS---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  212 AAIPLPLLPLMLTQLRYLT-ASHKVEIYSRIEVIFNRATESAKLDIIANAELILDASMHDEFVELLNINYSStEDLFHMT 290
Cdd:cd11721   78 VPSEDNLPRLILNQFKWLDhIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQE-NSELTVP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  291 TVQTLGNLSLSDRTQAKLRVRILDFATSGQCSDaiLPHLIRLLLNVLkidTDDSVRDLIGSLRGIFNWRHTNETE----K 366
Cdd:cd11721  157 ILDALSNLNLSPELLSEIREKVLSCLKTVPLED--LPVLVKFLLQSI---TATEALEIISKLRKNLDFSPLSDPSssgsS 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  367 ISASEDSKKSQLELFGFLELGLIRSKKFYQACQRSSASVPAAEF-TSFDMILLLLLIHVNEDNSLYIENILRRRIKLEHI 445
Cdd:cd11721  232 DKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDhKVIDLILLLILYSTNEDKRKSIESLLKKKIKSGFI 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  446 TVSILEEIRQHYRHILEQHITTLMNILHDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSPHLTTm 524
Cdd:cd11721  312 RTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRyYQQEVVGALITHIGSGNSSEVDA- 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  525 ALELLRELQRKSAKDVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAFPDPNLSPCLQLQEQVDMVVKKQLINSIDNI 604
Cdd:cd11721  391 ALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPLSEGSSIQDDLHIIVRKQLSNSSPKY 470

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  605 KKQGIIGCVQLIDAMARIANNGvdrDEFIASVENVDSLPDGRGKMAANLIIRTEASIGNSTESLALFFEELATVFNQRne 684
Cdd:cd11721  471 KRMGIIGAVTLVKHLASANSSD---DAVERSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQA-- 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  685 gtsgCELDNQFIAWACDLVTFRFQASFVTENVPEtlkgikleyqlninelddtdantesdvlniginisklvlspkvkac 764
Cdd:cd11721  546 ----SNLDPKFLEWLGETITEDFQESFVVDLDET---------------------------------------------- 575

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  765 dSIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPSFFeddnYVSVFENFEAEQQKDILSIYFHTVNWMRVSISAF 844
Cdd:cd11721  576 -SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFE----VDEKFDSLSTEQRSVVLDCLFYAINWFREVINAF 650

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  845 ASQRDPPTRRRVLSRLGELIRIEQRMKPLLARApvdfvappyqfltnvklsnqnqkrpgpkpaaklnatlpepdltgnqp 924
Cdd:cd11721  651 ATQKDASTKKKVLKRLRNLIELEGRLSKLLAHC----------------------------------------------- 683

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  925 siadftikvgqcktvktktdfeqmygpreRYRPMEVEIIMLLVEQKFVLNHQLEEEQMGEFLGLLELRFLLEDVVQKLEA 1004
Cdd:cd11721  684 -----------------------------YFRELDLEVFSLLKSGLVTDTSLELSEEEGVHLGPKELRFLLEDLNRKLEH 734

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1005 AVLRHHDSydADSFRPHLAKPEDFICDLLPCLHEVNNHLITLGEAIDNQLTEVSHVYSNLD-----------LFKDQFCY 1073
Cdd:cd11721  735 VLTSPKKK--RMPLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLlsnagqldapgPFVQENQY 812

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1074 IKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQPKTQWKRLEKQSVPQLANLTFQYFLKYEKSVLNLSTAVHLHR 1153
Cdd:cd11721  813 AKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKDLPLKELVSSLFKYLKSFEPSVPSLSTAVSLVQ 892

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1154 LLCNLLKLgslqsdaSQPRFQQAEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFLKKSNAKSQTELLTELVK 1233
Cdd:cd11721  893 LLQALMEK-------SPDRPQLREKLADLARNFLCRQWPDLSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKLEEIAGEA 965

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1234 QCSILNTKDK--ALTSFPNFKKANFPLLFRGLCEVLIHSLSGQVSVDSRG-----DKLKLWESAVDLLNGLLSIVQQVEQ 1306
Cdd:cd11721  966 LPELLEKKKDkdALETFPTLSKSTFPIFFRVLMEALIESVKKILSSAADTgggemERLLLWQSAVRVFKALVNLVKTFDK 1045

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810 1307 PRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTRFLHQLCCHSKSIKNTAIISYIPSLRETIETL 1386
Cdd:cd11721 1046 RPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPALKKSLETL 1125

                       1290      1300      1310
                 ....*....|....*....|....*....|....*.
gi 45580810 1387 VFRVKALLAANNCHSAFHMGNMINRDLHGDSIITPR 1422
Cdd:cd11721 1126 VYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 90-1434 2.30e-71

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 263.55  E-value: 2.30e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810     90 FELVLVRAGVQLDQGDSL-ILACDHVPIVSKLREIFTSASSYTDKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQ 168
Cdd:pfam14631   14 FVKLLKTAGVILKTGENQnEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCLLPCVPLQSEEASS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    169 IYQS-QNSMFMNFLMIDFMRDACVEVLLNKIEEV----AKSDRVIMGKAAIplpllplmlTQLRYLT-ASHKVEIYSRIE 242
Cdd:pfam14631   94 MVTSyQESLIKLLLGIEILQPAIIKTLFEKLPEFmfesVNSDGLNMPRLII---------NQLKWLDrIVDGKDLTSKLM 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    243 VIFNRATESAKLDIIANAELILDASMHD----EFVELLNINYSSTedlfhMTTVQTLGNLSLSDRTQAKLRVRILDFATS 318
Cdd:pfam14631  165 QLISVAPVELQHDIITSLPEILEDSQHNdvarELSSLLVENTQLT-----VPILDALSSLNLDPTLLSEVRQAVMGTLSA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    319 GQCSDaiLPHLIRLLLNVLkidTDDSVRDLIGSLRGIFNWRHTNETEKISASEDSKKSQLELFG------------FLEL 386
Cdd:pfam14631  240 VQLED--LPVVVKFILHSV---SATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSsgnqasssqdciSLVF 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    387 GLIRSKKFYQACQrSSASVPAAEFT-------SFDMILLLLLIHVNEDNSLYIENILRRRIKLEHITVSILEEIRQHYRH 459
Cdd:pfam14631  315 DVIKSAVRFQKTI-SEAWLKAIENIdsvsdhkVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHAL 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    460 ILEQHITTLMNILHDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSpHLTTMALELLRELQRKSAK 538
Cdd:pfam14631  394 VLRDYFPSILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSyCQQEVVGALVTHVCSGNE-AEVDVALELLLELVVLKPS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    539 DVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAFPDPNLSPClQLQEQVDMVVKKQLINSIDNIKKQGIIGCVQLIDA 618
Cdd:pfam14631  473 AMRLYAVFVKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSS-HIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGS 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    619 MArianngVDRDEFIASVENVdSLPDGRGKMAANLIIRTEASIGNSTESLALFFEELATVFNQRNegtsgceLDNQFIAW 698
Cdd:pfam14631  552 MA------ADRSKSGSSSQSA-SLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGK-------LDPKVLEW 617

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    699 ACDLVTFRFQASFVTENVPET----LKGIKLEYQLNINELDDTdantesdvlnIGINISKLVLSPKVKACD--------- 765
Cdd:pfam14631  618 IGQSVLNDFQDDFVVDLGPDIegdfPFPVKALYGLEEEESQGG----------IAINLLPLLAKDEQAKDEgevtaqekg 687

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    766 ----SIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPsffeDDNYVSVFENFEAEQQKDILSIYFHTVNWMRVSI 841
Cdd:pfam14631  688 qkrvSPLCLSPFFRLLRLCVEKQHDGDLEEIDGLLGCPLILT----DLEVGEKLESLSKKEREFLCSLLFHTINWFREVV 763

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    842 SAFASQRDPPTRRRVLSRLGELIRIEQRMKPLLARAPvDFVAPpyqfLTNVKLSNQNQKRPGpkpaaklnatlpEPDLTG 921
Cdd:pfam14631  764 NAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVTP-GYVPP----LANFDLDSSQKEEAS------------EAEESQ 826

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    922 NQPSIADFTIKVGQCKTVKTKTDFeqmygpRERYRPMEVEIIMLL---VEQKFVLNHQL-----EEEQMGEFLGLLELRf 993
Cdd:pfam14631  827 SEKSQLEKEFKGKEGKTGVSLQSY------RAFFRELDIEVFSVLhcgLLTKSLLDTEMhtkarEEVQLGPAELLFLLE- 899

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810    994 lleDVVQKLE----------AAVLRHHDSYDADSFRPHLAKPEDFI---CDLLP--CLHEVN--NHLITLgeaidnqLTE 1056
Cdd:pfam14631  900 ---DLSRKLEfmltpapakrAPFLKGKGDRNVGFSHLQQRSAQEIAhcvVQLLPplCNHLENihNYFQCL-------LAE 969

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1057 VSHVYSNLDLFKDQFCYIKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQPKTQWKRLEkQSVPQLANLTFQYFL 1136
Cdd:pfam14631  970 NHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLFAWSGFSQPENRSLLKSALGVLAGRLKEGEAE-LTLEELVSHSFEYLQ 1048

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1137 KYEKSVLNLSTAVHLHRLLCNLLKLGSlqsDASQPRfqqaEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFL 1216
Cdd:pfam14631 1049 NFRSSVPSFQCALCLIQLLIVIAEKSG---NPAAKR----EKIASLARQFLCQVWVTPSGEKEKGNKFNDALHTLLCIYL 1121

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1217 KKSNA--KSQTELLTELVKQCsILNTKDKALTSFPNFKKANFPLLFRGL---CEVLIHSLSGQVSVDSR---GDKLKLWE 1288
Cdd:pfam14631 1122 EHTDDvlKAIEEIAGEGVPEL-INSSKDASSSTFPTLTRQTFLVFFRVMmaeLEKSVRKIQPGTASDSQevqEEKLLYWN 1200

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810   1289 SAVDLLNGLLSIVQQVEQPRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTRFLHQLCCHSKSIK 1368
Cdd:pfam14631 1201 MAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMPLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQ 1280

                         1370      1380      1390      1400      1410      1420
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45580810   1369 NTAIISYIPSLRETIETLVFRVKALLAANNCHSAFHMGNMINRDLHGDSIITPRSSFAGEENSDDE 1434
Cdd:pfam14631 1281 DTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKNRDLQGEEILSQRSQESDEEEEEDS 1346
FANC cd11719
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 292-620 1.99e-06

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


Pssm-ID: 212593  Cd Length: 977  Bit Score: 52.62  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  292 VQTLGNLSLSDRTQAKLRVRILDFATSGQCSDaiLPHLIRLLLNVLKIDTDDSVRDLIGSLRGIFNWRHTNETEKISAS- 370
Cdd:cd11719  138 TSVFKDVCLTPEEMNLVVAKVLTMFSKLNLQE--IPPLVYQLLVLSSKGSRRSVLDGIIAFFRELDKQHREEQSSDELSe 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  371 -----EDSKKSQLELFGFLELGLIR------SKKFYQACQRSSaSVPAAEFTSFDMILLLLLIHVNEDNSLYIENILRRR 439
Cdd:cd11719  216 litapADELYHVEGTVILHIVFAIKldcelgRELLKHLKAGQQ-GDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSV 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  440 IK--------------------------------------LEHITVSIL--EEIRQHYRHILEQHITTLMNILHDFMREK 479
Cdd:cd11719  295 VKsfkdlqllqgskflqtlvpqrtcvstmilevvrnsvhsWDHVTQGLIefGFILMDSYGPKKILDGKAVEIGTSLSKMT 374

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580810  480 NRIVSDFAKSSYSILFKIFNSIQKNILKKLLELTCDKSSPHLTTmALELLRELQRKSAKDVQNcATLLIPMLDRISDLSL 559
Cdd:cd11719  375 NQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRTSSPINH-FLDLFSDIIMYAPLILQN-CSKVTETFDYLTFLPL 452

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45580810  560 TQTRVAMDLLCHVAFPDPNLspclqlQEQVDMVVKKQLINSIDNIKKQGIIGCVQLIDAMA 620
Cdd:cd11719  453 QTVQGLLKAVQPLLKISMSM------RDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFK 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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