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Conserved domains on  [gi|281362826|ref|NP_996310|]
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vacuolar protein sorting 13B, isoform B [Drosophila melanogaster]

Protein Classification

VPS13 family protein( domain architecture ID 13783056)

VPS13 family protein similar to intermembrane lipid transfer protein VPS13B that mediates the transfer of lipids between membranes at organelle contact sites

Gene Ontology:  GO:0032266|GO:0006869|GO:0016192
PubMed:  35491307
TCDB:  1.R.2.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 4-121 1.36e-24

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 98.41  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826    4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNlPVELVSGHIHELSILVPWTKLMSEPVKI 83
Cdd:pfam12624   1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDL-PIEVKSGHIGKLTLKIPWTNLKSEPVVI 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 281362826   84 VINTIEFVAKlPDSESKQRRASFQREQRRKSKRESVEQ 121
Cdd:pfam12624  80 EIEDVYLLAV-PKDESEEYDEEEEEKRELAAKKEKLAA 116
VPS13 super family cl38505
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 134-203 1.19e-03

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


The actual alignment was detected with superfamily member pfam16908:

Pssm-ID: 465309  Cd Length: 234  Bit Score: 40.71  E-value: 1.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362826  134 SSVVNKIINNINLQCHNIILKYvEDDIVVSMNV-------QTLNFSSAGEDWKPTMVDIHpvSVVMRKLLQVSDLTI 203
Cdd:pfam16908   3 ESLITKIIDNLQVTIKNIHIRY-EDSVSNPGHPfafgitlEELSAQSTDENWKPTFIQGT--SKIIHKLVELESLSV 76
 
Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 4-121 1.36e-24

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 98.41  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826    4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNlPVELVSGHIHELSILVPWTKLMSEPVKI 83
Cdd:pfam12624   1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDL-PIEVKSGHIGKLTLKIPWTNLKSEPVVI 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 281362826   84 VINTIEFVAKlPDSESKQRRASFQREQRRKSKRESVEQ 121
Cdd:pfam12624  80 EIEDVYLLAV-PKDESEEYDEEEEEKRELAAKKEKLAA 116
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-216 3.06e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 72.99  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826    4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNlPVELVSGHIHELSILVPWTKLMSEPVKI 83
Cdd:COG5043     2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGL-PIEVTSGLIGTLTLEIPWSSLKNKPVEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826   84 VINTIEFVA------KLPDSESKQRraSFQREQRRKSKRESVEQPDQTKSPGPASS------SSVVNKIINNINLQCHNI 151
Cdd:COG5043    81 YIEDIYLLIspqaknSLTREELPQS--QQALKQRQLDSWEILRETLEESSSSPNISrkqsfiESLITKLIDNIQIYIEDI 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362826  152 ILKYVEDDIVV-----SMNVQTLNFS--SAGEDWKPTMVDIHpvSVVMRKLLQVSDLtiCLDKRNTAGRIEV 216
Cdd:COG5043   159 HLRFEDNLSADlegpySFGLTLYSLRatSTDASWTEYFVSTD--SSCIHKLITLDYF--SIYWCEISPCITT 226
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 134-203 1.19e-03

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 40.71  E-value: 1.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362826  134 SSVVNKIINNINLQCHNIILKYvEDDIVVSMNV-------QTLNFSSAGEDWKPTMVDIHpvSVVMRKLLQVSDLTI 203
Cdd:pfam16908   3 ESLITKIIDNLQVTIKNIHIRY-EDSVSNPGHPfafgitlEELSAQSTDENWKPTFIQGT--SKIIHKLVELESLSV 76
 
Name Accession Description Interval E-value
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 4-121 1.36e-24

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 98.41  E-value: 1.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826    4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNlPVELVSGHIHELSILVPWTKLMSEPVKI 83
Cdd:pfam12624   1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDL-PIEVKSGHIGKLTLKIPWTNLKSEPVVI 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 281362826   84 VINTIEFVAKlPDSESKQRRASFQREQRRKSKRESVEQ 121
Cdd:pfam12624  80 EIEDVYLLAV-PKDESEEYDEEEEEKRELAAKKEKLAA 116
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-216 3.06e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 72.99  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826    4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNlPVELVSGHIHELSILVPWTKLMSEPVKI 83
Cdd:COG5043     2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGL-PIEVTSGLIGTLTLEIPWSSLKNKPVEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362826   84 VINTIEFVA------KLPDSESKQRraSFQREQRRKSKRESVEQPDQTKSPGPASS------SSVVNKIINNINLQCHNI 151
Cdd:COG5043    81 YIEDIYLLIspqaknSLTREELPQS--QQALKQRQLDSWEILRETLEESSSSPNISrkqsfiESLITKLIDNIQIYIEDI 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281362826  152 ILKYVEDDIVV-----SMNVQTLNFS--SAGEDWKPTMVDIHpvSVVMRKLLQVSDLtiCLDKRNTAGRIEV 216
Cdd:COG5043   159 HLRFEDNLSADlegpySFGLTLYSLRatSTDASWTEYFVSTD--SSCIHKLITLDYF--SIYWCEISPCITT 226
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 134-203 1.19e-03

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 40.71  E-value: 1.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281362826  134 SSVVNKIINNINLQCHNIILKYvEDDIVVSMNV-------QTLNFSSAGEDWKPTMVDIHpvSVVMRKLLQVSDLTI 203
Cdd:pfam16908   3 ESLITKIIDNLQVTIKNIHIRY-EDSVSNPGHPfafgitlEELSAQSTDENWKPTFIQGT--SKIIHKLVELESLSV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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