NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|46402175|ref|NP_997089|]
View 

lysophospholipid acyltransferase LPCAT4 [Mus musculus]

Protein Classification

glycerol-3-phosphate acyltransferase( domain architecture ID 10168560)

glycerol-3-phosphate acyltransferase (GPAT) catalyzes the incorporation of an acyl group from acylCoA into the acceptor glycerol 3-phosphate

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008374
SCOP:  4003349

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 109-306 8.98e-75

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


:

Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 235.19  E-value: 8.98e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAaPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRR 188
Cdd:cd07991  13 IKVHGKPDPPEAPRIIVA-NHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKER 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 189 ATSGgKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEF 268
Cdd:cd07991  92 ATDP-NWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRLLTQPANVLEVEF 170

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 46402175 269 LPVYQPSlEESKDPTLYANNVQRVMAQALGIPATECEF 306
Cdd:cd07991 171 LPVYTPS-EEGEDPKEFANRVRLIMANKLGLPATDWTG 207
 
Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 109-306 8.98e-75

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 235.19  E-value: 8.98e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAaPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRR 188
Cdd:cd07991  13 IKVHGKPDPPEAPRIIVA-NHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKER 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 189 ATSGgKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEF 268
Cdd:cd07991  92 ATDP-NWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRLLTQPANVLEVEF 170

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 46402175 269 LPVYQPSlEESKDPTLYANNVQRVMAQALGIPATECEF 306
Cdd:cd07991 171 LPVYTPS-EEGEDPKEFANRVRLIMANKLGLPATDWTG 207
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 109-298 1.90e-21

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 92.77  E-value: 1.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAAPHSTFFDPIVL---LPCDlPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEV 185
Cdd:COG0204  31 VRVEGLENLPADGPVLIVANHQSWLDILLLlaaLPRP-VRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQA 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 186 RRRATSGGkwpQVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIRYPNSLDTTSWAWRgPGVlkvlwltasqpc 261
Cdd:COG0204 110 VEALKAGE---SLVIFPEGTRSPDGRLLPFKTGAARlaleAGVPIVPVAIDGTERALPKGFLPR-PGK------------ 173

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 46402175 262 siVDVEFLPVYQPSLEESKDPTLYANNVQRVMAQALG 298
Cdd:COG0204 174 --VTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLA 208
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 123-233 7.94e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 85.10  E-value: 7.94e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175    123 VLVAAPHSTFFDPIVL---LPC--DLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKwpq 197
Cdd:smart00563   1 ALVVANHQSFLDPLVLsalLPRklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEW--- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 46402175    198 VLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIRY 233
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARlaleAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 109-231 1.48e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 76.16  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175   109 IRVRGQRASRLEAPVLVAAPHSTFFDPIvLLPCDLPK------VVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVV 182
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVL-LLSLALYKrgrplvFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 46402175   183 EEVRRrATSGGKWpqVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLI 231
Cdd:pfam01553  81 EYLVE-LLREGKL--VVIFPEGTRSREGELLPFKKGAFRlaieAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 109-232 3.64e-10

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 57.74  E-value: 3.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175   109 IRVRGQRASRLEAPVLVAAPHSTFFDPIVL---LPCDLpKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEV 185
Cdd:TIGR00530   4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLsaaFPPPI-VFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALKAA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 46402175   186 RRRATSGgkWPqVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIR 232
Cdd:TIGR00530  83 IEVLKQG--RS-IGVFPEGTRSRGRDILPFKKGAFHiaikAGVPILPVVLS 130
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 120-253 5.28e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 50.50  E-value: 5.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175  120 EAPVLVAAPHSTFFDPIVLLPCDLP-KVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGkwpQV 198
Cdd:PLN02901  49 DEPAVYVSNHQSFLDIYTLFHLGRPfKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLKRCMELLKKGA---SV 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46402175  199 LFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLI-----RYPNSLDttsWAWRgPGVLKVL 253
Cdd:PLN02901 126 FFFPEGTRSKDGKLAAFKKGAFSvaakTGVPVVPITLvgtgkIMPNGKE---GILN-PGSVKVV 185
 
Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 109-306 8.98e-75

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 235.19  E-value: 8.98e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAaPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRR 188
Cdd:cd07991  13 IKVHGKPDPPEAPRIIVA-NHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKER 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 189 ATSGgKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEF 268
Cdd:cd07991  92 ATDP-NWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRLLTQPANVLEVEF 170

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 46402175 269 LPVYQPSlEESKDPTLYANNVQRVMAQALGIPATECEF 306
Cdd:cd07991 171 LPVYTPS-EEGEDPKEFANRVRLIMANKLGLPATDWTG 207
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 109-298 1.90e-21

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 92.77  E-value: 1.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAAPHSTFFDPIVL---LPCDlPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEV 185
Cdd:COG0204  31 VRVEGLENLPADGPVLIVANHQSWLDILLLlaaLPRP-VRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQA 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 186 RRRATSGGkwpQVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIRYPNSLDTTSWAWRgPGVlkvlwltasqpc 261
Cdd:COG0204 110 VEALKAGE---SLVIFPEGTRSPDGRLLPFKTGAARlaleAGVPIVPVAIDGTERALPKGFLPR-PGK------------ 173

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 46402175 262 siVDVEFLPVYQPSLEESKDPTLYANNVQRVMAQALG 298
Cdd:COG0204 174 --VTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLA 208
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 109-252 2.32e-21

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 91.56  E-value: 2.32e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPCDLPKV--VSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVR 186
Cdd:cd07989  12 VRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIrfVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREALREAI 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 187 RRATSGGKwpqVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIRYPNSLDTTSWAWRGPGVLKV 252
Cdd:cd07989  92 EALKEGES---VVIFPEGTRSRDGELLPFKSGAFRlakeAGVPIVPVAISGTWGSLPKGKKLPRPGRVTV 158
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 123-233 7.94e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 85.10  E-value: 7.94e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175    123 VLVAAPHSTFFDPIVL---LPC--DLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKwpq 197
Cdd:smart00563   1 ALVVANHQSFLDPLVLsalLPRklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEW--- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 46402175    198 VLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIRY 233
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARlaleAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 109-231 1.48e-16

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 76.16  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175   109 IRVRGQRASRLEAPVLVAAPHSTFFDPIvLLPCDLPK------VVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVV 182
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVL-LLSLALYKrgrplvFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 46402175   183 EEVRRrATSGGKWpqVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLI 231
Cdd:pfam01553  81 EYLVE-LLREGKL--VVIFPEGTRSREGELLPFKKGAFRlaieAGVPIVPVAI 130
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 109-294 6.70e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 73.22  E-value: 6.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPC-------DLPKVVSRAENLSVPVIGALlrfnQAILVSRHDPASRRRV 181
Cdd:cd06551  14 LEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLlerglrrDVYGLMDEELLERYPFFTRL----GAFSVDRDSPRSAAKS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 182 VEEVRRRATSGGKWpqVLFFPEGTCSN-KKALLKFKPGAFI----AGVPVQPVLIRYPNSLDTtswawrgpgvlkvlwlt 256
Cdd:cd06551  90 LKYVARLLSKPGSV--VWIFPEGTRTRrDKRPLQFKPGVAHlaekAGVPIVPVALRYTFELFE----------------- 150

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 46402175 257 aSQPCSIVDVEFLPVYQPSLEESKDPTLYANNVQRVMA 294
Cdd:cd06551 151 -QFPEIFVRIGPPIPYAETALGEELAAELANRLTRLLD 187
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 109-232 3.64e-10

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 57.74  E-value: 3.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175   109 IRVRGQRASRLEAPVLVAAPHSTFFDPIVL---LPCDLpKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEV 185
Cdd:TIGR00530   4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLsaaFPPPI-VFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALKAA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 46402175   186 RRRATSGgkWPqVLFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLIR 232
Cdd:TIGR00530  83 IEVLKQG--RS-IGVFPEGTRSRGRDILPFKKGAFHiaikAGVPILPVVLS 130
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 120-253 5.28e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 50.50  E-value: 5.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175  120 EAPVLVAAPHSTFFDPIVLLPCDLP-KVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGkwpQV 198
Cdd:PLN02901  49 DEPAVYVSNHQSFLDIYTLFHLGRPfKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLKRCMELLKKGA---SV 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46402175  199 LFFPEGTCSNKKALLKFKPGAFI----AGVPVQPVLI-----RYPNSLDttsWAWRgPGVLKVL 253
Cdd:PLN02901 126 FFFPEGTRSKDGKLAAFKKGAFSvaakTGVPVVPITLvgtgkIMPNGKE---GILN-PGSVKVV 185
PLN02833 PLN02833
glycerol acyltransferase family protein
 199-299 3.80e-06

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 49.00  E-value: 3.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175  199 LFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLpvyQP-SLE 277
Cdd:PLN02833 241 LIFPEGTCVNNEYTVMFKKGAFELGCTVCPIAIKYNKIFVDAFWNSRKQSFTMHLLRLMTSWAVVCDVWYL---EPqTLR 317

                         90       100
                 ....*....|....*....|..
gi 46402175  278 ESKDPTLYANNVQRVMAQALGI 299
Cdd:PLN02833 318 PGETPIEFAERVRDMIAKRAGL 339
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 109-233 7.46e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 43.79  E-value: 7.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46402175 109 IRVRGQRASRLEAPVLVAAPHS-TFFDPIVLLPCDLPKV--VSRAENLSVPVIGALLRFNQAILVSR-------HDPASR 178
Cdd:cd07992  16 ITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVrfLAKADLFKNPLIGWLLESFGAIPVYRpkdlargGIGKIS 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46402175 179 RRVVEEVRRRATSGGKWpqVLFFPEGTCSNKKALLKFKPGAFIA----------GVPVQPVLIRY 233
Cdd:cd07992  96 NAAVFDAVGEALKAGGA--IGIFPEGGSHDRPRLLPLKAGAARMalealeagqkDVKIVPVGLNY 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH