|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
32-1267 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 843.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 32 CTFYEECGknpelsgGLTSLSNISCLSNTPARHVTGDHLALLQRVCPrlYNGPNDT-YACCSTKQLVSLDSSLSITKALL 110
Cdd:TIGR00917 1 CAMYDICG-------ARSDGKVLNCPYNIPSVKPPDLLSSLIQSLCQ--YSHPTISgNVCCTETQFDTLRSNVQQAIPFI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 111 TRCPACSENFVSIHCHNTCSPDQSLFINVTRVVQRDPGQlpAVVAYEAFYQRSFAEKAYESCSRVRIPAAASLAVGSMCG 190
Cdd:TIGR00917 72 VRCPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 191 VYGSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGqaLADGMKPLDGKITPCNESQGEDSAACSCQDCAASC-PVIPPP 269
Cdd:TIGR00917 150 GAKNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCP--VSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCkAKVPTQ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 270 PALRPS--------------FYMGRMPGWLALIIIFTAVFVLLSVVLVYLRVA-SNRNKNKTAGSQEAPNLPRKRRFSPH 334
Cdd:TIGR00917 227 KKHSCSiklgvkcvdfilaiLYIVLVSVFLGGGLLHPVRGKKKTSQMGTLSEAdGEINSVNQQKDQNTPQRNWGQLSTVQ 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 335 TVLGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTA 414
Cdd:TIGR00917 307 GHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIAT 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 415 KNRSSYKYDSLLLGPKNFSGILSLDLLQEllelqerlrhlQVWSHEAQRNISLQDICYAPLKPHNtsltdCCVNSLLQYF 494
Cdd:TIGR00917 387 VQTSSHEKAPEILTDDNLKLLFDIQKKVS-----------QLFANYEGELITLDSPCFKPNHPYN-----CFIYSTCKKL 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 495 QNNHTLLlltaNQTLNGQTSLVDWKDHFLYCANAPLtykdgtalalSCIADYGAPVFPFLAVGGYQGTDYSEAEALIITF 574
Cdd:TIGR00917 451 QNMYSKL----KPENYDDYGGVDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTF 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 575 SINNYPADDPRMAHAKLWEEAFLKEMQSFqRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSY 654
Cdd:TIGR00917 517 PVNNFVNKTNKTEKAVAWEKAFIQLAKDE-LLPMVQATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDS 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 655 SRWSRVAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQR-- 732
Cdd:TIGR00917 596 PRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGvd 675
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 733 -------EAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEAS 805
Cdd:TIGR00917 676 neqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDK 755
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 806 RPDVVCCFS------SRNLPPPKQKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPK 879
Cdd:TIGR00917 756 RVDCFPCIKtskssiSAEKGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQ 835
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 880 DSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGMNAICSSAGCESFSLTQkiqyasEFPNQSYVAIAASSWVDDFID 959
Cdd:TIGR00917 836 DSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYLV 909
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 960 WLTPSSSCCRIYtrgPHKDEFCPSTDTSfnCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNL 1039
Cdd:TIGR00917 910 WLSPQASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDL 984
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1040 SSDGQII-ASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRkvpgtdpnFEVFPYTISNVFYQQYLTVLPEGIFTLA 1118
Cdd:TIGR00917 985 QGYATIIqASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSSK--------MEVYPYSVFYVFFEQYLTIWKTAIINLS 1056
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1119 LCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTR 1198
Cdd:TIGR00917 1057 IALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSR 1136
|
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 253970442 1199 LERAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLG 1267
Cdd:TIGR00917 1137 NHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
30-283 |
1.28e-93 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 301.06 E-value: 1.28e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 30 GFCTFYEECGKNPELSGGLTslsnisCLSNTPARHVTGDHLALLQRVCPRLYNgpNDTYACCSTKQLVSLDSSLSITKAL 109
Cdd:pfam16414 1 GRCAWYGECGKKSLFGKDLP------CPYNGPAKPLDDEVRDLLAELCPLLFA--DETPVCCDADQLNTLRSNLKLAEGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 110 LTRCPACSENFVSIHCHNTCSPDQSLFINVTRVVQRDPGQLpAVVAYEAFYQRSFAEKAYESCSRVRIPAAASLAVGSMC 189
Cdd:pfam16414 73 LSRCPACKKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKE-YVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLIC 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 190 GVYgsalCNAQRWLNFQGDTGNGLAPLDITFHLlePGQALADGMKPLDGKITPCNESQgEDSAACSCQDCAASCPVIPPP 269
Cdd:pfam16414 152 GGA----CNYTRWLKFMGDKKNGGSPFQINFPD--PPEEDPSGMVPLNPNTKDCNESY-DASYACSCVDCPLSCPPPPQL 224
|
250
....*....|....*
gi 253970442 270 PALRP-SFYMGRMPG 283
Cdd:pfam16414 225 PPPPHgPCKVGGLDG 239
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
589-1240 |
2.88e-51 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 195.27 E-value: 2.88e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 589 AKLWEEAFlkEMQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDSKATL 668
Cdd:pfam02460 174 SKEWEDEL--SQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPIL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 669 GLGGVAVVLGAVVAAMGFYSYLGVPSSlVIIQVVPFLVLAVGADNIFIFVLEYQRL-PRMPGEQReahIGRTLGSVAPSM 747
Cdd:pfam02460 252 AALGLLSPVMAIVSSFGLLFWMGFPFN-SIVCVTPFLVLAIGVDDMFLMVAAWQRTtATLSVKKR---MGEALSEAGVSI 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 748 LLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPdvvCCF----------SSRN 817
Cdd:pfam02460 328 TITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRH---CLFvwatsspqriDSEG 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 818 LPPPKQK--EGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYF-----LFL 890
Cdd:pfam02460 405 SEPDKSHniEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLslrekHFW 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 891 NRYLEV-----GPPvyfDTTsgyNFSTEAGMNAIcssagcesfsltqkiqyASEFPNQSYVAIAASS--WVDDFIDWLtp 963
Cdd:pfam02460 485 PEGLQIqvavnNPP---NLT---IPESRDRMNEM-----------------VDEFENTPYSLGPNSTlfWLREYENFL-- 539
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 964 sssccriYTRGPHKDEfcpstDTSFNCLKNCMNRTLG-PVRPTTEQFHKYlpwflNDTpnircpKGGLAAYRTSVNLssd 1042
Cdd:pfam02460 540 -------STLNMEEEE-----DEEKEWSYGNLPSFLKaPGNSHWAGDLVW-----DDN------TTMVTKFRFTLAG--- 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1043 gqiiasqfmayhKPLRNSQDFTEALRasrllaanitaELRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFV 1122
Cdd:pfam02460 594 ------------KGLSTWNDRTRALQ-----------EWRSIADQYPEFNVTVFDEDAPFADQYLTILPSTIQNIVITLI 650
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1123 PTFVVCYLLLGLDIrSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERA 1202
Cdd:pfam02460 651 CMFIVCFLFIPNPP-CVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERV 729
|
650 660 670
....*....|....*....|....*....|....*...
gi 253970442 1203 KDATIFMGSAVFAGvAMTNFPGILILGFAQAQLIQIFF 1240
Cdd:pfam02460 730 VDALEALGWPVFQG-GLSTILGVLVLLFVPSYMVVVFF 766
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
684-815 |
6.48e-50 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 173.54 E-value: 6.48e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 684 MGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEqrEAHIGRTLGSVAPSMLLCSLSEAICFFLGAL 763
Cdd:pfam12349 24 LGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEALGEVGPSITLTSLTEILAFLLGAL 101
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 253970442 764 TSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSS 815
Cdd:pfam12349 102 TDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
592-1268 |
3.26e-36 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 149.65 E-value: 3.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 592 WEEAFLKEMQSFQRSTADKFQIAFSAErSLEDEINRTTIQDLPVFAISYLIVFLYISLALgsySRWSrvAVDSKATLGLG 671
Cdd:TIGR00918 359 WQRNFSEEVQQSLPKNSSQKILVFSST-TLDDILKKFSDVSAIRIVSGYLLMLAYACLTM---LRWD--CAKSQGSVGLA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 672 GVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEY-QRLPRMPGEQReahIGRTLGSVAPSMLLC 750
Cdd:TIGR00918 433 GVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFsETGQNIPFEER---TGECLKRTGASVVLT 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 751 SLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSS--------------- 815
Cdd:TIGR00918 510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSpcsarviqiepqaya 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 816 RNLPPPK----------------------------------QKEGLLLC------------------------------- 830
Cdd:TIGR00918 590 DGSAPPVysshmqstvqlrteydpgtqhyyttneprshlsvQPSDPLSCqspdiagstrdllsqfedskaaclslpcarw 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 831 ----FFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVgPPVYFDTTS 906
Cdd:TIGR00918 670 tlatFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSF-YNMYAVTQG 748
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 907 GYNFSTeagmnaicssagcesfSLTQKIQYASEFPNQSYVAI-----AASSWVDDFIDWL-------TPSSSCCRIyTRG 974
Cdd:TIGR00918 749 NFDYPT----------------QQQLLYDLHQSFSSVKYVLKedngqLPRMWLHYFRDWLqglqkafDEDWRDGRI-TKE 811
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 975 PHKDefcPSTDTSF------------------NCLKNCMNRTLGPVRPttEQFHKYLP-WFLNDTPNIRCPKGGLAAYR- 1034
Cdd:TIGR00918 812 NYRN---GSDDAVLaykllvqtghrdkpvdkeQLTTQRLVNADGIINP--NAFYIYLSaWVSNDPVAYAASQANIYPHPp 886
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1035 -----------TSVNLSSDGQIIASQFMAYHKPLRNSQDFTEALRASRLLAANitAELRKVPGtdpnfevFPYTISNVFY 1103
Cdd:TIGR00918 887 ewlhdkndydpENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNN--YEGFGLPS-------YPSGYPFLFW 957
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1104 QQYLTVLPEGIFTLALCFVPTFVVCYLLLgLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFV 1183
Cdd:TIGR00918 958 EQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFT 1036
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1184 SHITRSFaVSTKPTRLERAKDATIFMGSAVFAGvAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVL 1263
Cdd:TIGR00918 1037 VHIALGF-LTAIGDRNRRAVLALEHMFAPVLDG-ALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLL 1114
|
....*
gi 253970442 1264 SYLGP 1268
Cdd:TIGR00918 1115 SMFGP 1119
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
558-1239 |
2.78e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 84.53 E-value: 2.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 558 GYQGTDYSE-AEALIITFSINNYPADDPRMAhaklweEAFLKEMQSF-QRSTADKFQIAFSAERSLEDEINRTTIQDLPV 635
Cdd:COG1033 149 LYVGRLVSPdGKATLIVVTLDPDPLSSDLDR------KEVVAEIRAIiAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAI 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 636 F-AISYLIVFLYISLALGSYsRW-------SRVAVdskatlglggvavvlgavVAAMGFYSYLGVPSSLVIIqVVPFLVL 707
Cdd:COG1033 223 FfPLALLLILLLLFLFFRSL-RGvllpllvVLLAV------------------IWTLGLMGLLGIPLSPLTI-LVPPLLL 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 708 AVGADNIFIFVLEYQRLPRMPGEQREAhIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQ 787
Cdd:COG1033 283 AIGIDYGIHLLNRYREERRKGLDKREA-LREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 788 MTAFVALLSLDSKRQEASRpdvvccfssrnlppPKQKEGLLLCFFRKIYTpfLLHRFIRPVVLLLFLVLFGAnLYLMCNI 867
Cdd:COG1033 362 LTLLPALLSLLPRPKPKTR--------------RLKKPPELGRLLAKLAR--FVLRRPKVILVVALVLAVVS-LYGISRL 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 868 SVGLDQDLALPKDS-YLIDYFLFLNRYLEVGP-PVYFDTTSGYNFSTEAGMNAIcssagcESFSltqkiQYASEFPNqsy 945
Cdd:COG1033 425 KVEYDFEDYLPEDSpIRQDLDFIEENFGGSDPlEVVVDTGEPDGLKDPEVLKEI------DRLQ-----DYLESLPE--- 490
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 946 vaIAASSWVDDFIDWLTpsssccRIYTRGPHKDEFCPSTDTSfncLKNCMNRTLGPVRPTTEQFhkylpwflndtpnirc 1025
Cdd:COG1033 491 --VGKVLSLADLVKELN------QALNEGDPKYYALPESREL---LAQLLLLLSSPPGDDLSRF---------------- 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1026 pkgglaayrtsvnLSSDGQiiASQFMAYHKPLRNSQ--DFTEALRAsrLLAANITAELRKVPGTDpNFEVFPYTISNVFY 1103
Cdd:COG1033 544 -------------VDEDYS--AARVTVRLKDLDSEEikALVEEVRA--FLAENFPPDGVEVTLTG-SAVLFAAINESVIE 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1104 QQyltvlpegIFTLALCFVPTFVVCYLLLGlDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFV 1183
Cdd:COG1033 606 SQ--------IRSLLLALLLIFLLLLLAFR-SLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYT 676
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 253970442 1184 SHITRSFavstkptRLERAKDATIFM---------GSAVFaGVAMTNFPGILILGFAQAQLIQIF 1239
Cdd:COG1033 677 IHFLSRY-------REERRKGGDLEEairralrttGKAIL-FTSLTLAAGFGVLLFSSFPPLADF 733
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
690-801 |
9.70e-07 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 52.29 E-value: 9.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 690 LGVPSSLVIIQVVpfLVLAVGAD-NIFIfVLEYQR-LPRmpGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMP 767
Cdd:pfam03176 196 IGLSTFALNLLVV--LLIAVGTDyALFL-VSRYREeLRA--GEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLP 270
|
90 100 110
....*....|....*....|....*....|....
gi 253970442 768 AVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKR 801
Cdd:pfam03176 271 VFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW 304
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
326-797 |
4.19e-06 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 51.40 E-value: 4.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 326 PRKRRFSPHTVLGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVElWSAPKSQARKEKAFHDEHFGpff 405
Cdd:COG1033 377 PKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFG--- 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 406 RTNQIFV---TAKNRSSYKYDSLllgpknfsgilsldllqellelqerlrhlqVWSHEAQRNISLQdicyaPLKPHNTSL 482
Cdd:COG1033 453 GSDPLEVvvdTGEPDGLKDPEVL------------------------------KEIDRLQDYLESL-----PEVGKVLSL 497
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 483 TDccvnsllqyfqnnhtlLLLTANQTLNGqtslvdwkdhflycaNAPLTYKDGTALALSCIADYGAPVFPFLAVGGYQGT 562
Cdd:COG1033 498 AD----------------LVKELNQALNE---------------GDPKYYALPESRELLAQLLLLLSSPPGDDLSRFVDE 546
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 563 DYSEAealIITFSINNYPADDprmahaklwEEAFLKEMQSF--QRSTADKFQIAFSAERSLEDEINRTTIQDLP-VFAIS 639
Cdd:COG1033 547 DYSAA---RVTVRLKDLDSEE---------IKALVEEVRAFlaENFPPDGVEVTLTGSAVLFAAINESVIESQIrSLLLA 614
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 640 YLIVFLYISLALGSysrWSR---------VAVdskatlglggvavvlgavVAAMGFYSYLGVPSSLVIIQVVPfLVLAVG 710
Cdd:COG1033 615 LLLIFLLLLLAFRS---LRLglislipnlLPI------------------LLTFGLMGLLGIPLNIATAVVAS-IALGIG 672
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 711 ADNiFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTA 790
Cdd:COG1033 673 VDY-TIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751
|
....*..
gi 253970442 791 FVALLSL 797
Cdd:COG1033 752 LPALLLL 758
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1115-1238 |
1.76e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 49.22 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1115 FTLALCFVPTFVVCYLLLGlDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVE----FVSHITRSF 1190
Cdd:pfam00873 335 KTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVDdaivVVENIERVL 413
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 253970442 1191 AVSTKPTR---------LERAKDATIFMGSAVFAGVA-MTNFPGILILGFAQAQLIQI 1238
Cdd:pfam00873 414 EENGLKPLeaayksmgeIGGALVAIALVLSAVFLPILfLGGLTGRIFRQFAITIVLAI 471
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
322-415 |
2.10e-05 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 48.99 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 322 APNLPRKRRFSPHTvlGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVElwSAPK-SQARkeKAFH--D 398
Cdd:COG2409 332 WPRRPRRRRAAAPE--SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDAD--SLPAdSPSR--QGYDalA 405
|
90
....*....|....*..
gi 253970442 399 EHFGPFFrTNQIFVTAK 415
Cdd:COG2409 406 EHFPPGS-NGPLTVVVE 421
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1097-1241 |
8.19e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.33 E-value: 8.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1097 TISNVFyqqylTVLPEGIFtlalcFVptFVVCYLLLGlDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAV 1176
Cdd:COG3696 333 AIHTVT-----KNLLEGAL-----LV--ILVLFLFLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 253970442 1177 GM-------SVEFV-SHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAmtnfpgILILGFaqaqlIQIFFF 1241
Cdd:COG3696 400 GIivdgavvMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF-----LPIFTL 461
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
637-786 |
8.80e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.15 E-value: 8.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 637 AISYLIVFLYISLALGSYSRWSRVAVDSKATLGLGgvavvlgavvaaMGFYSYLGVPSSLVIIqVVPFLVLAVGADNIfI 716
Cdd:COG4258 646 LLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLT------------LAILGLLGIPLNLFHL-IALLLVLGIGIDYA-L 711
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 717 FVLEyqrlprmpGEQREAHIGRTLGSVapsmLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLL 786
Cdd:COG4258 712 FFTE--------GLLDKGELARTLLSI----LLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
691-797 |
5.94e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.44 E-value: 5.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 691 GVPSSLvIIQVVPFLVLAVGADnIFIFVLEYQRlprmpgEQREAH-----IGRTLGSVAPSMLLCSLSEAICFFLGALTS 765
Cdd:TIGR00921 616 GIPSFL-AMATTISIILGLGMD-YSIHLAERYF------EERKEHgpkeaITHTMERTGPGILFSGLTTAGGFLSLLLSH 687
|
90 100 110
....*....|....*....|....*....|..
gi 253970442 766 MPAVRTFALTSGLAIIFDFLLQMTAFVALLSL 797
Cdd:TIGR00921 688 FPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
684-797 |
7.66e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.06 E-value: 7.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 684 MGFYSYLGVPSSLVIIQVVPfLVLAVGADNIfIFVLEyqrlpRMpgeQREAHIGRTLGS--------VAPSMLLCSLSEA 755
Cdd:TIGR00921 235 LGIMGWLGIPLYATTLLAVP-MLIGVGIDYG-IQTLN-----RY---EEERDIGRAKGEaivtavrrTGRAVLIALLTTS 304
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 253970442 756 ICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSL 797
Cdd:TIGR00921 305 AGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
695-807 |
9.56e-04 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 43.83 E-value: 9.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 695 SLVIIQVVpFLVLAVG--ADNIFIFVLEYQRLPRMPGEQREAhIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTF 772
Cdd:TIGR03480 320 HLNLISVA-FAVLFIGlgVDFAIQFSLRYREERFRGGNHREA-LSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSEL 397
|
90 100 110
....*....|....*....|....*....|....*
gi 253970442 773 ALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRP 807
Cdd:TIGR03480 398 GIIAGTGMFIALFVTLTVLPALLRLLRPPRRRKPP 432
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1130-1240 |
1.14e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 43.29 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1130 LLLGLDIRS---GILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSF------------AVST 1194
Cdd:TIGR00921 208 LVLLLDFKRwwrPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeerdigrakgeAIVT 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 253970442 1195 KPTRLERAKDATIFMGSAVFAGVAMTNFPGI------LILGFAQAQLIQIFF 1240
Cdd:TIGR00921 288 AVRRTGRAVLIALLTTSAGFAALALSEFPMVsefglgLVAGLITAYLLTLLV 339
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
1114-1224 |
3.53e-03 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 42.02 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253970442 1114 IFTLALCFVPTFVVCYLLLGlDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVE----FVSHITRS 1189
Cdd:TIGR00915 341 VHTLIEAIVLVFLVMYLFLQ-NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDdaivVVENVERV 419
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 253970442 1190 FAVSTKPTRlERAKDAtifMG-------------SAVFAGVAMtnFPG 1224
Cdd:TIGR00915 420 MAEEGLPPK-EATRKS---MGqiqgalvgiamvlSAVFVPMAF--FGG 461
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1114-1178 |
7.67e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 40.86 E-value: 7.67e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 253970442 1114 IFTLALCFVPTFVVCYLLLGlDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGM 1178
Cdd:COG0841 334 VKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGI 397
|
|
| |
