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Conserved domains on  [gi|148762950|ref|NP_997289|]
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BEN domain-containing protein 4 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BEN smart01025
The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP ...
 412-490 5.42e-13

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.


:

Pssm-ID: 214981  Cd Length: 80  Bit Score: 64.31  E-value: 5.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762950   412 RRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGetgpeRRPLDPVKVTCLREFIRMHCTS--NPDWWMPSEEQINKVFSD 489
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSG-----KKPLDPNKVQAIREYLEERFPSvdLDEDWKVCIQAINNKCRR 75


                   .
gi 148762950   490 A 490
Cdd:smart01025  76 L 76
BRLZ smart00338
basic region leucin zipper;
325-362 1.78e-03

basic region leucin zipper;


:

Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.77  E-value: 1.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 148762950   325 RCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLK 362
Cdd:smart00338  27 EIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
 
Name Accession Description Interval E-value
BEN smart01025
The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP ...
 412-490 5.42e-13

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.


Pssm-ID: 214981  Cd Length: 80  Bit Score: 64.31  E-value: 5.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762950   412 RRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGetgpeRRPLDPVKVTCLREFIRMHCTS--NPDWWMPSEEQINKVFSD 489
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSG-----KKPLDPNKVQAIREYLEERFPSvdLDEDWKVCIQAINNKCRR 75


                   .
gi 148762950   490 A 490
Cdd:smart01025  76 L 76
BEN pfam10523
BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and ...
 412-487 2.36e-06

BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The BEN domain-containing protein 3 (BEND3) is shown to interact (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat and SNF2 HeliC region of ERCC6L) which stimulates the ERCC6L translocase and ATPase activities.


Pssm-ID: 463133  Cd Length: 76  Bit Score: 45.45  E-value: 2.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148762950  412 RRLLRYlirfVFTTDELKYSCGLGKRKRSVQSGetgpeRRPLDPVKVTCLREFIRMHCTS--NPDWWMPSEEQINKVF 487
Cdd:pfam10523   4 RKLLVK----LFPEDTLANHSGTGKRSPAFPPN-----KKGLDPLKVQLIRNYVEERFPEnkNEEWWNECVPRINKTI 72
BRLZ smart00338
basic region leucin zipper;
325-362 1.78e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.77  E-value: 1.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 148762950   325 RCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLK 362
Cdd:smart00338  27 EIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
cc_RasGRP1_C cd22290
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; ...
 321-368 3.96e-03

C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.


Pssm-ID: 412086  Cd Length: 55  Bit Score: 35.49  E-value: 3.96e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 148762950 321 GYCPRCQELEQEVISLQQENEELRRKLESipvpCQTVLDYLKMVLQHH 368
Cdd:cd22290    5 LRKPTYQELEKENSNLKAENEALKIQLKD----AQRRIEALRLELRKH 48
 
Name Accession Description Interval E-value
BEN smart01025
The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP ...
 412-490 5.42e-13

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.


Pssm-ID: 214981  Cd Length: 80  Bit Score: 64.31  E-value: 5.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148762950   412 RRLLRYLIRFVFTTDELKYSCGLGKRKRSVQSGetgpeRRPLDPVKVTCLREFIRMHCTS--NPDWWMPSEEQINKVFSD 489
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSG-----KKPLDPNKVQAIREYLEERFPSvdLDEDWKVCIQAINNKCRR 75


                   .
gi 148762950   490 A 490
Cdd:smart01025  76 L 76
BEN pfam10523
BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and ...
 412-487 2.36e-06

BEN domain; The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The BEN domain-containing protein 3 (BEND3) is shown to interact (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat and SNF2 HeliC region of ERCC6L) which stimulates the ERCC6L translocase and ATPase activities.


Pssm-ID: 463133  Cd Length: 76  Bit Score: 45.45  E-value: 2.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148762950  412 RRLLRYlirfVFTTDELKYSCGLGKRKRSVQSGetgpeRRPLDPVKVTCLREFIRMHCTS--NPDWWMPSEEQINKVF 487
Cdd:pfam10523   4 RKLLVK----LFPEDTLANHSGTGKRSPAFPPN-----KKGLDPLKVQLIRNYVEERFPEnkNEEWWNECVPRINKTI 72
BRLZ smart00338
basic region leucin zipper;
325-362 1.78e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.77  E-value: 1.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 148762950   325 RCQELEQEVISLQQENEELRRKLESIPVPCQTVLDYLK 362
Cdd:smart00338  27 EIEELERKVEQLEAENERLKKEIERLRRELEKLKSELE 64
cc_RasGRP1_C cd22290
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; ...
 321-368 3.96e-03

C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins; RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.


Pssm-ID: 412086  Cd Length: 55  Bit Score: 35.49  E-value: 3.96e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 148762950 321 GYCPRCQELEQEVISLQQENEELRRKLESipvpCQTVLDYLKMVLQHH 368
Cdd:cd22290    5 LRKPTYQELEKENSNLKAENEALKIQLKD----AQRRIEALRLELRKH 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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