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Conserved domains on  [gi|46485501|ref|NP_997496|]
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cadherin-15 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 723-782 1.96e-30

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 113.79  E-value: 1.96e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   723 ADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 782
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 155-255 2.21e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 2.21e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 155 VFRGRILEGAIPGTFVTRAEATDADDPEtdNAALRFSILEQGSPELFSIDEHTGEIRTVQvGLDREVVAVYNLTLQVADM 234
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 46485501 235 SGDGLTATASAIISVDDVNDN 255
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 378-478 4.94e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 378 PLRTSIAEGAPPGTSVATFSARDPDTEQLQRISYS-KDYDPEDWLQVDRATGRIQTQRVLSpaspFLKDGWYRAIILALD 456
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 46485501 457 NAMPPSTATGTLSIEILEVNDH 478
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
270-366 1.91e-18

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   270 EAVSGVDVGRLEVEDKDLPgsPNWVARFTILEGDPDGQFKIYTDPktneGVLSVVKPLDYESREQYELRVSVQNEaplqt 349
Cdd:pfam00028   8 NAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS----- 76

                          90
                  ....*....|....*..
gi 46485501   350 aAPRAQRGQTRVSVWVQ 366
Cdd:pfam00028  77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-147 5.32e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 5.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501  51 ISVSENHKrLPYPLVQIK---SDKQQLGSVIYSIqgpgVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLG 127
Cdd:cd11304   4 VSVPENAP-PGTVVLTVSatdPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 46485501 128 GSTLEDPTDLEIVVVDQNDN 147
Cdd:cd11304  79 GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
487-579 4.03e-09

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   487 SGSLC-SEPDQGPGLLLGATDEDLPPHGAPFHFQLNPRVpdlGRNWSLSQINvshARLRLRHQV---SEGLHRLSLLLQD 562
Cdd:pfam00028   2 SASVPeNAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDT---GDISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 46485501   563 SGEPPQQREQTLNVTVC 579
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 723-782 1.96e-30

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 113.79  E-value: 1.96e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   723 ADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 782
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 155-255 2.21e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 2.21e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 155 VFRGRILEGAIPGTFVTRAEATDADDPEtdNAALRFSILEQGSPELFSIDEHTGEIRTVQvGLDREVVAVYNLTLQVADM 234
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 46485501 235 SGDGLTATASAIISVDDVNDN 255
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-257 1.38e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 1.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    175 ATDADDPEtdNAALRFSILEQGSPELFSIDEHTGEIRTVQVgLDREVVAVYNLTLQVADMSGDGLTATASAIISVDDVND 254
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 46485501    255 NAP 257
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 378-478 4.94e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 378 PLRTSIAEGAPPGTSVATFSARDPDTEQLQRISYS-KDYDPEDWLQVDRATGRIQTQRVLSpaspFLKDGWYRAIILALD 456
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 46485501 457 NAMPPSTATGTLSIEILEVNDH 478
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
156-249 8.05e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 8.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   156 FRGRILEGAIPGTFVTRAEATDADDPetDNAALRFSILEQGSPELFSIDEHTGEIRTVQVgLDREVVAVYNLTLQVADMS 235
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 46485501   236 GDGLTATASAIISV 249
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
382-473 1.22e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   382 SIAEGAPPGTSVATFSARDPDTEQLQRISYSKDYD-PEDWLQVDRATGRIQTQRVLSPASPflkdGWYRAIILALDNAMP 460
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 46485501   461 PSTATGTLSIEIL 473
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
270-366 1.91e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   270 EAVSGVDVGRLEVEDKDLPgsPNWVARFTILEGDPDGQFKIYTDPktneGVLSVVKPLDYESREQYELRVSVQNEaplqt 349
Cdd:pfam00028   8 NAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS----- 76

                          90
                  ....*....|....*..
gi 46485501   350 aAPRAQRGQTRVSVWVQ 366
Cdd:pfam00028  77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-147 5.32e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 5.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501  51 ISVSENHKrLPYPLVQIK---SDKQQLGSVIYSIqgpgVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLG 127
Cdd:cd11304   4 VSVPENAP-PGTVVLTVSatdPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 46485501 128 GSTLEDPTDLEIVVVDQNDN 147
Cdd:cd11304  79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 69-149 1.48e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501     69 SDKQQLGSVIYSIqgpgVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNR 148
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 46485501    149 P 149
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-370 2.40e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 270 EAVSGVDVGRLEVEDKDLPgsPNWVARFTILEGDPDGQFKIytDPKTneGVLSVVKPLDYESREQYELRVSVQNEAPLQt 349
Cdd:cd11304   9 NAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGGGPP- 81

                        90       100
                ....*....|....*....|.
gi 46485501 350 aapraQRGQTRVSVWVQDTNE 370
Cdd:cd11304  82 -----LSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 397-480 1.67e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    397 SARDPDTEQLQRISYSKDYDPED-WLQVDRATGRIQTQRVLSpaspFLKDGWYRAIILALDNAMPPSTATGTLSIEILEV 475
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 46485501    476 NDHAP 480
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 282-372 7.85e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 7.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    282 VEDKDLPgsPNWVARFTILEGDPDGQFKIytDPKTneGVLSVVKPLDYESREQYELRVSVQNeaplqtAAPRAQRGQTRV 361
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTATV 69

                           90
                   ....*....|.
gi 46485501    362 SVWVQDTNEAP 372
Cdd:smart00112  70 TITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
49-141 2.46e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 2.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    49 PPISVSENHKR--LPYPLVQIKSDKQQLGSVIYSIQGPGVDeeprNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDL 126
Cdd:pfam00028   1 YSASVPENAPVgtEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 46485501   127 GGSTLEDPTDLEIVV 141
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
487-579 4.03e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   487 SGSLC-SEPDQGPGLLLGATDEDLPPHGAPFHFQLNPRVpdlGRNWSLSQINvshARLRLRHQV---SEGLHRLSLLLQD 562
Cdd:pfam00028   2 SASVPeNAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDT---GDISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 46485501   563 SGEPPQQREQTLNVTVC 579
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 723-782 1.96e-30

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 113.79  E-value: 1.96e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   723 ADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 782
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 155-255 2.21e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 2.21e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 155 VFRGRILEGAIPGTFVTRAEATDADDPEtdNAALRFSILEQGSPELFSIDEHTGEIRTVQvGLDREVVAVYNLTLQVADM 234
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 46485501 235 SGDGLTATASAIISVDDVNDN 255
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-257 1.38e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 1.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    175 ATDADDPEtdNAALRFSILEQGSPELFSIDEHTGEIRTVQVgLDREVVAVYNLTLQVADMSGDGLTATASAIISVDDVND 254
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 46485501    255 NAP 257
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 378-478 4.94e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 4.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 378 PLRTSIAEGAPPGTSVATFSARDPDTEQLQRISYS-KDYDPEDWLQVDRATGRIQTQRVLSpaspFLKDGWYRAIILALD 456
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 46485501 457 NAMPPSTATGTLSIEILEVNDH 478
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
156-249 8.05e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 8.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   156 FRGRILEGAIPGTFVTRAEATDADDPetDNAALRFSILEQGSPELFSIDEHTGEIRTVQVgLDREVVAVYNLTLQVADMS 235
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 46485501   236 GDGLTATASAIISV 249
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
382-473 1.22e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   382 SIAEGAPPGTSVATFSARDPDTEQLQRISYSKDYD-PEDWLQVDRATGRIQTQRVLSPASPflkdGWYRAIILALDNAMP 460
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 46485501   461 PSTATGTLSIEIL 473
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
270-366 1.91e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   270 EAVSGVDVGRLEVEDKDLPgsPNWVARFTILEGDPDGQFKIYTDPktneGVLSVVKPLDYESREQYELRVSVQNEaplqt 349
Cdd:pfam00028   8 NAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS----- 76

                          90
                  ....*....|....*..
gi 46485501   350 aAPRAQRGQTRVSVWVQ 366
Cdd:pfam00028  77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-147 5.32e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 5.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501  51 ISVSENHKrLPYPLVQIK---SDKQQLGSVIYSIqgpgVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLG 127
Cdd:cd11304   4 VSVPENAP-PGTVVLTVSatdPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 46485501 128 GSTLEDPTDLEIVVVDQNDN 147
Cdd:cd11304  79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 69-149 1.48e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501     69 SDKQQLGSVIYSIqgpgVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNR 148
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 46485501    149 P 149
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 270-370 2.40e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501 270 EAVSGVDVGRLEVEDKDLPgsPNWVARFTILEGDPDGQFKIytDPKTneGVLSVVKPLDYESREQYELRVSVQNEAPLQt 349
Cdd:cd11304   9 NAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGGGPP- 81

                        90       100
                ....*....|....*....|.
gi 46485501 350 aapraQRGQTRVSVWVQDTNE 370
Cdd:cd11304  82 -----LSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 397-480 1.67e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    397 SARDPDTEQLQRISYSKDYDPED-WLQVDRATGRIQTQRVLSpaspFLKDGWYRAIILALDNAMPPSTATGTLSIEILEV 475
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 46485501    476 NDHAP 480
Cdd:smart00112  77 NDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-147 2.03e-12

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 63.90  E-value: 2.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501  48 IPPISVSENHKRlPYPLVQIKSDKQQLGSVIYSIQGPGvDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLG 127
Cdd:cd00031   1 IPDGSAVEGRSR-GSFRVSIPTDLIASSGEIIKISAAG-KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                        90       100
                ....*....|....*....|
gi 46485501 128 GSTLEDPTDLEIVVVDQNDN 147
Cdd:cd00031  79 ANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 282-372 7.85e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 7.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    282 VEDKDLPgsPNWVARFTILEGDPDGQFKIytDPKTneGVLSVVKPLDYESREQYELRVSVQNeaplqtAAPRAQRGQTRV 361
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTATV 69

                           90
                   ....*....|.
gi 46485501    362 SVWVQDTNEAP 372
Cdd:smart00112  70 TITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
49-141 2.46e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 2.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501    49 PPISVSENHKR--LPYPLVQIKSDKQQLGSVIYSIQGPGVDeeprNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDL 126
Cdd:pfam00028   1 YSASVPENAPVgtEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 46485501   127 GGSTLEDPTDLEIVV 141
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
487-579 4.03e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46485501   487 SGSLC-SEPDQGPGLLLGATDEDLPPHGAPFHFQLNPRVpdlGRNWSLSQINvshARLRLRHQV---SEGLHRLSLLLQD 562
Cdd:pfam00028   2 SASVPeNAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDT---GDISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 46485501   563 SGEPPQQREQTLNVTVC 579
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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