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Conserved domains on  [gi|47086003|ref|NP_998370|]
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cation-dependent mannose-6-phosphate receptor precursor [Danio rerio]

Protein Classification

cation-dependent mannose-6-phosphate receptor( domain architecture ID 1563581)

cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component of the lysosomal enzyme targeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and transports them to endosomal compartments

Gene Ontology:  GO:0015031
PubMed:  3156583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG27 super family cl39051
Autophagy-related protein 27;
24-265 8.24e-115

Autophagy-related protein 27;


The actual alignment was detected with superfamily member pfam02157:

Pssm-ID: 476860  Cd Length: 254  Bit Score: 329.82  E-value: 8.24e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003    24 TSNCKLVSD----SESQRKALRLLEPLTNQNF-TTEGQEKEKYSYIFQVCGDAGG-VKNAGLIQQEK-GGKTIRIGDYSK 96
Cdd:pfam02157   6 EKKCDLVGEesseSQKERALLKRLEPLANKSFeVTVGSGPETYTYNFRVCREVGKtASDAGLVQIDKkNGKETVIGRINE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003    97 TVATAGSDWVLLIYEGGEKYDSHCSSEERKAMIMIS-CSSSSKSAFSVVMEENQKQKNCYYLFELDTTAVCPAVSSKLSA 175
Cdd:pfam02157  86 TQVFNGSDWIMLIYKGGDEYGSHCGKEKRKAIIMIScNRKVLADNFTIVIEEREKEQDCFYLFELDSSLACPPEDSHLSV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003   176 GSIVLIVVISSLTVYIIGGFLYQRLVVGAKGVEQFPNFAFWSEIGNLSADGCDFVCRSRgNREEPPTYRGVGTEPLGEEP 255
Cdd:pfam02157 166 GSILLIVFFSLVAVYIIGGFLYQRLVVGAKGMEQFPNYAFWQDLGNLVADGCDFVCRSK-PRNAPAAYRGVGDDQLGEES 244

                         250
                  ....*....|
gi 47086003   256 EERDDHLLPM 265
Cdd:pfam02157 245 EERDDHLLPM 254
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 24-265 8.24e-115

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 329.82  E-value: 8.24e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003    24 TSNCKLVSD----SESQRKALRLLEPLTNQNF-TTEGQEKEKYSYIFQVCGDAGG-VKNAGLIQQEK-GGKTIRIGDYSK 96
Cdd:pfam02157   6 EKKCDLVGEesseSQKERALLKRLEPLANKSFeVTVGSGPETYTYNFRVCREVGKtASDAGLVQIDKkNGKETVIGRINE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003    97 TVATAGSDWVLLIYEGGEKYDSHCSSEERKAMIMIS-CSSSSKSAFSVVMEENQKQKNCYYLFELDTTAVCPAVSSKLSA 175
Cdd:pfam02157  86 TQVFNGSDWIMLIYKGGDEYGSHCGKEKRKAIIMIScNRKVLADNFTIVIEEREKEQDCFYLFELDSSLACPPEDSHLSV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003   176 GSIVLIVVISSLTVYIIGGFLYQRLVVGAKGVEQFPNFAFWSEIGNLSADGCDFVCRSRgNREEPPTYRGVGTEPLGEEP 255
Cdd:pfam02157 166 GSILLIVFFSLVAVYIIGGFLYQRLVVGAKGMEQFPNYAFWQDLGNLVADGCDFVCRSK-PRNAPAAYRGVGDDQLGEES 244

                         250
                  ....*....|
gi 47086003   256 EERDDHLLPM 265
Cdd:pfam02157 245 EERDDHLLPM 254
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 24-265 8.24e-115

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 329.82  E-value: 8.24e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003    24 TSNCKLVSD----SESQRKALRLLEPLTNQNF-TTEGQEKEKYSYIFQVCGDAGG-VKNAGLIQQEK-GGKTIRIGDYSK 96
Cdd:pfam02157   6 EKKCDLVGEesseSQKERALLKRLEPLANKSFeVTVGSGPETYTYNFRVCREVGKtASDAGLVQIDKkNGKETVIGRINE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003    97 TVATAGSDWVLLIYEGGEKYDSHCSSEERKAMIMIS-CSSSSKSAFSVVMEENQKQKNCYYLFELDTTAVCPAVSSKLSA 175
Cdd:pfam02157  86 TQVFNGSDWIMLIYKGGDEYGSHCGKEKRKAIIMIScNRKVLADNFTIVIEEREKEQDCFYLFELDSSLACPPEDSHLSV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086003   176 GSIVLIVVISSLTVYIIGGFLYQRLVVGAKGVEQFPNFAFWSEIGNLSADGCDFVCRSRgNREEPPTYRGVGTEPLGEEP 255
Cdd:pfam02157 166 GSILLIVFFSLVAVYIIGGFLYQRLVVGAKGMEQFPNYAFWQDLGNLVADGCDFVCRSK-PRNAPAAYRGVGDDQLGEES 244

                         250
                  ....*....|
gi 47086003   256 EERDDHLLPM 265
Cdd:pfam02157 245 EERDDHLLPM 254
ATG27 pfam09451
Autophagy-related protein 27;
177-237 5.58e-03

Autophagy-related protein 27;


Pssm-ID: 430622  Cd Length: 261  Bit Score: 37.31  E-value: 5.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086003   177 SIVLIVVISSLTVYIIGGFLYQRLVVGAKGVEQFPNFAFWSEIGNLSADGCDFVC---RSRGNR 237
Cdd:pfam09451 196 TWFFIILFLFTAAYLIFGSWLNYNRYGARGWDLLPHGDFWRDLPYLLKDVVRKVVgtvQGSGSR 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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