NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|47523126|ref|NP_999033|]
View 

ficolin-2 precursor [Sus scrofa]

Protein Classification

fibrinogen-related domain-containing protein( domain architecture ID 10053370)

fibrinogen-related domain-containing protein contains a C terminal globular domain similar to that of fibrinogen, and may be involved in one or more of a variety of binding interactions and functions including complement activation, signaling and regulation

PubMed:  1304888
SCOP:  4002544

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
112-321 6.16e-116

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 333.44  E-value: 6.16e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126 112 PRTCKELLTRGHILSGWHTIYLPDC-QPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHI 190
Cdd:cd00087   3 PRDCSEVLQRGGRTSGVYTIQPPGSnEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLEKI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126 191 HALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGDSLTSHNNSLFTTKDQDNDQYASNCAVL 270
Cdd:cd00087  83 HLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDALSYHNGMKFSTFDRDNDGASGNCAES 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 47523126 271 YQGAWWYNSCHVSNLNGRYLGGSH-GSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:cd00087 162 YSGGWWYNSCHASNLNGRYYSGGHrNEYDNGINWATWKGSTYSLKFTEMKIR 213
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
112-321 6.16e-116

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 333.44  E-value: 6.16e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126 112 PRTCKELLTRGHILSGWHTIYLPDC-QPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHI 190
Cdd:cd00087   3 PRDCSEVLQRGGRTSGVYTIQPPGSnEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLEKI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126 191 HALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGDSLTSHNNSLFTTKDQDNDQYASNCAVL 270
Cdd:cd00087  83 HLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDALSYHNGMKFSTFDRDNDGASGNCAES 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 47523126 271 YQGAWWYNSCHVSNLNGRYLGGSH-GSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:cd00087 162 YSGGWWYNSCHASNLNGRYYSGGHrNEYDNGINWATWKGSTYSLKFTEMKIR 213
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
112-321 1.48e-109

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 317.30  E-value: 1.48e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126    112 PRTCKELLTRGHILSGWHTIYLPD-CQPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHI 190
Cdd:smart00186   2 PRDCSDVLQNGGKTSGLYTIYPDGsSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNENI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126    191 HALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGD-SLTSHNNSLFTTKDQDNDQYASNCAV 269
Cdd:smart00186  82 HLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEADGYRLHIGGY-SGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCAE 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47523126    270 LYQGAWWYNSCHVSNLNGRYlgGSHGSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:smart00186 161 EYGGGWWYNNCHAANLNGRY--YPNNNYDNGINWATWKGSWYSLKFTEMKIR 210
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
112-321 1.26e-81

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 246.67  E-value: 1.26e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126   112 PRTCKELLTRGHILSGWHTIYL-PDCQPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGS-QLGEFWLGNDH 189
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPdGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGNDK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126   190 IHALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGD-------SLTSHNNSLFTTKDQDNDQ 262
Cdd:pfam00147  82 IHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENY-IGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 47523126   263 YASNCAVLYQGAWWYNSCHVSNLNGRYLGGSHGSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:pfam00147 161 PDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSKQNGIIWATWKGRWYSMKKAEMKIR 219
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
114-155 3.89e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 46.02  E-value: 3.89e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 47523126  114 TCKELLTRGHIL-SGWHTIY---LPDCQPLTVLCDMDTDGGGWTVF 155
Cdd:NF040941   1 SCWEILQAGPSApSGVYWIDpdgMGGLAPFQVYCDMTTDGGGWTLV 46
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
112-321 6.16e-116

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 333.44  E-value: 6.16e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126 112 PRTCKELLTRGHILSGWHTIYLPDC-QPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHI 190
Cdd:cd00087   3 PRDCSEVLQRGGRTSGVYTIQPPGSnEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLEKI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126 191 HALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGDSLTSHNNSLFTTKDQDNDQYASNCAVL 270
Cdd:cd00087  83 HLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGY-SGTAGDALSYHNGMKFSTFDRDNDGASGNCAES 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 47523126 271 YQGAWWYNSCHVSNLNGRYLGGSH-GSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:cd00087 162 YSGGWWYNSCHASNLNGRYYSGGHrNEYDNGINWATWKGSTYSLKFTEMKIR 213
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
112-321 1.48e-109

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 317.30  E-value: 1.48e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126    112 PRTCKELLTRGHILSGWHTIYLPD-CQPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHI 190
Cdd:smart00186   2 PRDCSDVLQNGGKTSGLYTIYPDGsSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNENI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126    191 HALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGD-SLTSHNNSLFTTKDQDNDQYASNCAV 269
Cdd:smart00186  82 HLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEADGYRLHIGGY-SGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCAE 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 47523126    270 LYQGAWWYNSCHVSNLNGRYlgGSHGSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:smart00186 161 EYGGGWWYNNCHAANLNGRY--YPNNNYDNGINWATWKGSWYSLKFTEMKIR 210
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
112-321 1.26e-81

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 246.67  E-value: 1.26e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126   112 PRTCKELLTRGHILSGWHTIYL-PDCQPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGS-QLGEFWLGNDH 189
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPdGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGNDK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47523126   190 IHALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFvEGNAGD-------SLTSHNNSLFTTKDQDNDQ 262
Cdd:pfam00147  82 IHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENY-IGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 47523126   263 YASNCAVLYQGAWWYNSCHVSNLNGRYLGGSHGSFANGVNWSSGKGYNYSYKVSEMKFR 321
Cdd:pfam00147 161 PDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSKQNGIIWATWKGRWYSMKKAEMKIR 219
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
114-155 3.89e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 46.02  E-value: 3.89e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 47523126  114 TCKELLTRGHIL-SGWHTIY---LPDCQPLTVLCDMDTDGGGWTVF 155
Cdd:NF040941   1 SCWEILQAGPSApSGVYWIDpdgMGGLAPFQVYCDMTTDGGGWTLV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH