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Conserved domains on  [gi|47550729|ref|NP_999874|]
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WD repeat-containing protein 48 [Danio rerio]

Protein Classification

WD repeat WDR48 family protein( domain architecture ID 10078073)

WD repeat WDR48 family protein similar to WD repeat-containing protein 48, a regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-300 3.59e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.03  E-value: 3.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTE 189
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 190 KVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYS 269
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 47550729 270 GGRDRKIYCTDLRNPDMRVLICEEKAPVLRM 300
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 509-673 5.16e-57

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


:

Pssm-ID: 463358  Cd Length: 171  Bit Score: 190.58  E-value: 5.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   509 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHSSSGAKTL- 580
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   581 ------KKDRLSASDMLQVRKVMEHVYEKIinldmESQATSSSANdkPGEQEKEEDVSVMAEEKIELMCLDQVLDPNMDL 654
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKL-----ESLTPEMKPP--SPDEDENADKKLKPEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 47550729   655 RTVKHFIWKSGGDLTIHYR 673
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-300 3.59e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.03  E-value: 3.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTE 189
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 190 KVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYS 269
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 47550729 270 GGRDRKIYCTDLRNPDMRVLICEEKAPVLRM 300
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 509-673 5.16e-57

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 190.58  E-value: 5.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   509 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHSSSGAKTL- 580
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   581 ------KKDRLSASDMLQVRKVMEHVYEKIinldmESQATSSSANdkPGEQEKEEDVSVMAEEKIELMCLDQVLDPNMDL 654
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKL-----ESLTPEMKPP--SPDEDENADKKLKPEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 47550729   655 RTVKHFIWKSGGDLTIHYR 673
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 COG2319
WD40 repeat [General function prediction only];
30-389 7.45e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 7.45e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTE 189
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 190 KVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAFT---- 265
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV----AFSpdgk 301

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 266 HIYSGGRDRKIYCTDLRNPDmrvliceekapvLRMELDRSADPPQSIWVSTTKSFVnkwslkamhnfrASGDYDN----- 340
Cdd:COG2319 302 LLASGSDDGTVRLWDLATGK------------LLRTLTGHTGAVRSVAFSPDGKTL------------ASGSDDGtvrlw 357

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 47550729 341 DCSTPltplctQPEQVIKGGTSIVQC-HILNDKRHILTKDTNNSVAFWDV 389
Cdd:COG2319 358 DLATG------ELLRTLTGHTGAVTSvAFSPDGRTLASGSADGTVRLWDL 401
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 561-673 3.07e-46

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 158.99  E-value: 3.07e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 561 KFNKIPFYLQPHSSSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDMESQAtsssandkpgeqekeedvSVMAEEK 638
Cdd:cd17041   1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47550729 639 IELMCLDQVLDPNMDLRTVKHFIWKSGGDLTIHYR 673
Cdd:cd17041  63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-286 2.70e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-TGTVIISGSTEKV 191
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  192 LRVWDPRTCAKLMKLKGHTDNVKSL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NEAFTHIYS 269
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                        170
                 ....*....|....*..
gi 47550729  270 GGRDRKIYCTDLRNPDM 286
Cdd:PLN00181 636 GSADHKVYYYDLRNPKL 652
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 3.20e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.20e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47550729    199 TCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-238 8.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 8.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550729   203 LMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-300 3.59e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.03  E-value: 3.59e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTE 189
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 190 KVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYS 269
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 47550729 270 GGRDRKIYCTDLRNPDMRVLICEEKAPVLRM 300
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 509-673 5.16e-57

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 190.58  E-value: 5.16e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   509 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHSSSGAKTL- 580
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   581 ------KKDRLSASDMLQVRKVMEHVYEKIinldmESQATSSSANdkPGEQEKEEDVSVMAEEKIELMCLDQVLDPNMDL 654
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKL-----ESLTPEMKPP--SPDEDENADKKLKPEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 47550729   655 RTVKHFIWKSGGDLTIHYR 673
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 COG2319
WD40 repeat [General function prediction only];
30-389 7.45e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 7.45e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTE 189
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 190 KVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAFT---- 265
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV----AFSpdgk 301

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 266 HIYSGGRDRKIYCTDLRNPDmrvliceekapvLRMELDRSADPPQSIWVSTTKSFVnkwslkamhnfrASGDYDN----- 340
Cdd:COG2319 302 LLASGSDDGTVRLWDLATGK------------LLRTLTGHTGAVRSVAFSPDGKTL------------ASGSDDGtvrlw 357

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 47550729 341 DCSTPltplctQPEQVIKGGTSIVQC-HILNDKRHILTKDTNNSVAFWDV 389
Cdd:COG2319 358 DLATG------ELLRTLTGHTGAVTSvAFSPDGRTLASGSADGTVRLWDL 401
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 561-673 3.07e-46

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 158.99  E-value: 3.07e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 561 KFNKIPFYLQPHSSSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDMESQAtsssandkpgeqekeedvSVMAEEK 638
Cdd:cd17041   1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47550729 639 IELMCLDQVLDPNMDLRTVKHFIWKSGGDLTIHYR 673
Cdd:cd17041  63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
WD40 COG2319
WD40 repeat [General function prediction only];
33-300 5.50e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 5.50e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMST 112
Cdd:COG2319  39 VASLAASPDGARLAAGAGDLTLLLLDAAAGAL---LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEKVL 192
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---------TLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 193 RVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAF----THIY 268
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV----AFspdgRLLA 262

                       250       260       270
                ....*....|....*....|....*....|..
gi 47550729 269 SGGRDRKIYCTDLRNPDMRVLICEEKAPVLRM 300
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-238 2.31e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.19  E-value: 2.31e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 110
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC---LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 111 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 190
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---------TLRGHENGVNSVAFSPDGYLLASGSEDG 241

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 47550729 191 VLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-276 2.35e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 2.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  37 QLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTH 116
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGAL---LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 117 KDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttssLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWD 196
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 197 PRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvneAF----THIYSGGR 272
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV----AFspdgKLLASGSA 224


                ....
gi 47550729 273 DRKI 276
Cdd:COG2319 225 DGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
31-199 3.89e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.89e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCM 110
Cdd:COG2319 247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL---LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 111 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEK 190
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR---------TLTGHTGAVTSVAFSPDGRTLASGSADG 394


                ....*....
gi 47550729 191 VLRVWDPRT 199
Cdd:COG2319 395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-282 6.44e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 6.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 109 CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT------------------------ASNNTV----- 159
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtlkghtgpvrdvaasadgtylasgSSDKTIrlwdl 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 160 ----TTSSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIR 235
Cdd:cd00200  81 etgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 47550729 236 LWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSGGRDRKIYCTDLR 282
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
87-389 7.78e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 7.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSG 166
Cdd:COG2319   6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA---------TLLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 167 NKDSIYSLAMNQTGTVIISGSTEKVLRVWDPRTCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIA 246
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 247 TYRVHDEGVWALqvneAF----THIYSGGRDRKIYCTDLRNPDmrvliceekapvLRMELDRSADPPQSIWVSTTKSFVn 322
Cdd:COG2319 157 TLTGHSGAVTSV----AFspdgKLLASGSDDGTVRLWDLATGK------------LLRTLTGHTGAVRSVAFSPDGKLL- 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47550729 323 kwslkamhnfrASGDYDN-----DCSTPltplctQPEQVIKGGTSIVQC-HILNDKRHILTKDTNNSVAFWDV 389
Cdd:COG2319 220 -----------ASGSADGtvrlwDLATG------KLLRTLTGHSGSVRSvAFSPDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
29-104 9.62e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 9.62e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47550729  29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNA 104
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL---LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-286 2.70e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-TGTVIISGSTEKV 191
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  192 LRVWDPRTCAKLMKLKGHTDNVKSL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NEAFTHIYS 269
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                        170
                 ....*....|....*..
gi 47550729  270 GGRDRKIYCTDLRNPDM 286
Cdd:PLN00181 636 GSADHKVYYYDLRNPKL 652
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-286 1.64e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 1.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729 206 LKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSGGRDRKIYCTDLRNPD 285
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84


                .
gi 47550729 286 M 286
Cdd:cd00200  85 C 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 3.20e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.20e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47550729    199 TCAKLMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-238 8.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 8.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550729   203 LMKLKGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-217 1.48e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   10 AGRRKVQV----SYvIRDEVEKYNRNGVnaLQL-DPALNRLFTAGRDSIIRIWSVNQHKQDPYIasmehhtdwvndiilc 84
Cdd:PLN00181 530 ASRSKLSGicwnSY-IKSQVASSNFEGV--VQVwDVARSQLVTEMKEHEKRVWSIDYSSADPTL---------------- 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   85 cngktLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNtltaltasNNTVTTSSL 164
Cdd:PLN00181 591 -----LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLR--------NPKLPLCTM 657

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 47550729  165 SGNKDSIYSLAMNQTGTvIISGSTEKVLRVWDPRTCAK------LMKLKGHTdNVKSLL 217
Cdd:PLN00181 658 IGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISginetpLHSFMGHT-NVKNFV 714
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 68-103 2.58e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.58e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 47550729     68 IASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWN 103
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 44-202 7.97e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 7.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   44 RLFTAGRDSIIRIWSV-----NQHKQDPyIASMEHHTDWVNDIILCCNGK-TLISASSDTTVKVWNAHKGFCMSTLRTHK 117
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIpeeglTQNISDP-IVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  118 DYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSlsgnKDSIYSLAMNQTGTVIISGSTEKVLRVWDP 197
Cdd:PTZ00421 169 DQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKS----QRCLWAKRKDLIITLGCSKSQQRQIMLWDT 244


                 ....*
gi 47550729  198 RTCAK 202
Cdd:PTZ00421 245 RKMAS 249
WD40 pfam00400
WD domain, G-beta repeat;
68-103 1.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550729    68 IASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWN 103
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 106-145 1.59e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.59e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 47550729    106 KGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
107-145 4.70e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 47550729   107 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 83-239 4.82e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 4.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   83 LCCNG--KTLISASS-DTTVKVWNAHKGFCMSTLRTHKDYVKALAYAK-DKELVASAGLDRQIFLWDVNTLTALTASNNT 158
Cdd:PLN00181 538 ICWNSyiKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  159 VTTSSLSGNKDSIYSLAMnqtgtviisGSTEKVLRVWDPRTCA-KLMKLKGHTDNVkSLLLNRDGTQCLSGSSDGTIRLW 237
Cdd:PLN00181 618 ANICCVQFPSESGRSLAF---------GSADHKVYYYDLRNPKlPLCTMIGHSKTV-SYVRFVDSSTLVSSSTDNTLKLW 687


                 ..
gi 47550729  238 SL 239
Cdd:PLN00181 688 DL 689
PTZ00421 PTZ00421
coronin; Provisional
 41-151 1.33e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729   41 ALNRLFTAGRDSIIRIWSVNQHKQDPYIASmehHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD-Y 119
Cdd:PTZ00421 137 AMNVLASAGADMVVNVWDVERGKAVEVIKC---HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaK 213

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 47550729  120 VKALAYAKDKELVASAGLD----RQIFLWDVNTLTA 151
Cdd:PTZ00421 214 SQRCLWAKRKDLIITLGCSksqqRQIMLWDTRKMAS 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 162-196 4.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 47550729    162 SSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWD 196
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
161-196 6.81e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 6.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 47550729   161 TSSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 134-306 2.42e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  134 SAGLDRQIFLWDVNT--LTALTASNntvtTSSLSGNKD-----SIYSLAMNqtgtVIISGSTEKVLRVWDPRTCAKLMKL 206
Cdd:PTZ00421  93 TASEDGTIMGWGIPEegLTQNISDP----IVHLQGHTKkvgivSFHPSAMN----VLASAGADMVVNVWDVERGKAVEVI 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47550729  207 KGHTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEG-----VWALQVNEAFTHIYSGGRDRKIYCTDL 281
Cdd:PTZ00421 165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrcLWAKRKDLIITLGCSKSQQRQIMLWDT 244

                        170       180
                 ....*....|....*....|....*
gi 47550729  282 RnpDMrvliceeKAPVLRMELDRSA 306
Cdd:PTZ00421 245 R--KM-------ASPYSTVDLDQSS 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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