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Conserved domains on  [gi|445931023|ref|WP_000008878|]
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MULTISPECIES: nitroreductase family protein [Streptococcus]

Protein Classification

nitroreductase family protein( domain architecture ID 10790284)

nitroreductase family protein similar to nitroreductase, which catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMR2 COG3560
Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction ...
 2-204 3.93e-121

Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction only];


:

Pssm-ID: 442781  Cd Length: 196  Bit Score: 341.01  E-value: 3.93e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   2 SFLEELKNRRSIYALGRNTEVSDEKIVEIIKEAVRQSPSAFNSQTSRVVILLNDEVTKFWDeLVANDLVETMkvqgaPET 81
Cdd:COG3560    1 DFLEAIKNRRSIYALGKNLPISDEEIEEIIKEAVKHTPSAFNSQSSRVVVLFGEEHDKLWD-ITKETLRKIV-----PAE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  82 AIAGTKEKLASFGASKGTVLFFEDQDVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALsAELGLGGNLQHYNPVIDA 161
Cdd:COG3560   75 AFAPTEEKINSFAAGYGTVLFFEDQDVVKGLQEQFPLYADNFPVWSEQSSGMAQYAVWTAL-AEEGIGASLQHYNPLIDE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 445931023 162 SVQAVYGVPASWKLRGQLNFGSIEAETGEKEFMNDDDRFKVIG 204
Cdd:COG3560  154 AVAKEWNIPASWKLRAQMPFGSIEAPAGEKEFIPDEERFKVFK 196
 
Name Accession Description Interval E-value
FMR2 COG3560
Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction ...
 2-204 3.93e-121

Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction only];


Pssm-ID: 442781  Cd Length: 196  Bit Score: 341.01  E-value: 3.93e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   2 SFLEELKNRRSIYALGRNTEVSDEKIVEIIKEAVRQSPSAFNSQTSRVVILLNDEVTKFWDeLVANDLVETMkvqgaPET 81
Cdd:COG3560    1 DFLEAIKNRRSIYALGKNLPISDEEIEEIIKEAVKHTPSAFNSQSSRVVVLFGEEHDKLWD-ITKETLRKIV-----PAE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  82 AIAGTKEKLASFGASKGTVLFFEDQDVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALsAELGLGGNLQHYNPVIDA 161
Cdd:COG3560   75 AFAPTEEKINSFAAGYGTVLFFEDQDVVKGLQEQFPLYADNFPVWSEQSSGMAQYAVWTAL-AEEGIGASLQHYNPLIDE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 445931023 162 SVQAVYGVPASWKLRGQLNFGSIEAETGEKEFMNDDDRFKVIG 204
Cdd:COG3560  154 AVAKEWNIPASWKLRAQMPFGSIEAPAGEKEFIPDEERFKVFK 196
Frm2-like cd02140
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-201 3.69e-107

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380317  Cd Length: 192  Bit Score: 305.38  E-value: 3.69e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   3 FLEELKNRRSIYALGRNTEVSDEKIVEIIKEAVRQSPSAFNSQTSRVVILLNDEVTKFWDelVANDLVETMKVQGAPETa 82
Cdd:cd02140    1 FLEAAKARRTIYALGKNSPVSDEEIEEIVKEAVKHVPSSFNSQSSRAVILLGDEHKKLWD--IVKDTLRPLVPAEAFEA- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  83 iagTKEKLASFGASKGTVLFFEDQDVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALSAElGLGGNLQHYNPVIDAS 162
Cdd:cd02140   78 ---TKEKLNGFKAGYGTVLFFEDQDVVKGLQEQFPAYADNFPVWSEQSSGMAQIAVWTALALE-GIGANLQHYNPLIDAA 153

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 445931023 163 VQAVYGVPASWKLRGQLNFGSIEAETGEKEFMNDDDRFK 201
Cdd:cd02140  154 VAKKWNIPSNWKLRAQLVFGSPEAPPGEKTFIPDEDRVK 192
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-182 8.18e-20

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 82.05  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023    7 LKNRRSIYALgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDEV-TKFWDELVANDLVETMKVQGAPETAIAG 85
Cdd:pfam00881   1 IRQRRSVRKF-DPEPVPKEVLEEIL-EAARRAPSAGNLQPWRFYVVTDGELrYRLAEAALELLLVEPAAALLLLLRRDAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   86 TKEKLASFGASKGTVLFfedqdVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALsAELGLGGNLQHYNPviDASVQA 165
Cdd:pfam00881  79 LKLLLQDFLRGAPVLIV-----ITASLSTYLRKAAERAYREALLDAGAAAQNLLLAA-TSLGLGSCPIGGFD--AAAVRE 150

                         170
                  ....*....|....*..
gi 445931023  166 VYGVPASWKLRGQLNFG 182
Cdd:pfam00881 151 LLGLPDDERLVGLIAVG 167
 
Name Accession Description Interval E-value
FMR2 COG3560
Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction ...
 2-204 3.93e-121

Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction only];


Pssm-ID: 442781  Cd Length: 196  Bit Score: 341.01  E-value: 3.93e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   2 SFLEELKNRRSIYALGRNTEVSDEKIVEIIKEAVRQSPSAFNSQTSRVVILLNDEVTKFWDeLVANDLVETMkvqgaPET 81
Cdd:COG3560    1 DFLEAIKNRRSIYALGKNLPISDEEIEEIIKEAVKHTPSAFNSQSSRVVVLFGEEHDKLWD-ITKETLRKIV-----PAE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  82 AIAGTKEKLASFGASKGTVLFFEDQDVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALsAELGLGGNLQHYNPVIDA 161
Cdd:COG3560   75 AFAPTEEKINSFAAGYGTVLFFEDQDVVKGLQEQFPLYADNFPVWSEQSSGMAQYAVWTAL-AEEGIGASLQHYNPLIDE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 445931023 162 SVQAVYGVPASWKLRGQLNFGSIEAETGEKEFMNDDDRFKVIG 204
Cdd:COG3560  154 AVAKEWNIPASWKLRAQMPFGSIEAPAGEKEFIPDEERFKVFK 196
Frm2-like cd02140
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-201 3.69e-107

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380317  Cd Length: 192  Bit Score: 305.38  E-value: 3.69e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   3 FLEELKNRRSIYALGRNTEVSDEKIVEIIKEAVRQSPSAFNSQTSRVVILLNDEVTKFWDelVANDLVETMKVQGAPETa 82
Cdd:cd02140    1 FLEAAKARRTIYALGKNSPVSDEEIEEIVKEAVKHVPSSFNSQSSRAVILLGDEHKKLWD--IVKDTLRPLVPAEAFEA- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  83 iagTKEKLASFGASKGTVLFFEDQDVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALSAElGLGGNLQHYNPVIDAS 162
Cdd:cd02140   78 ---TKEKLNGFKAGYGTVLFFEDQDVVKGLQEQFPAYADNFPVWSEQSSGMAQIAVWTALALE-GIGANLQHYNPLIDAA 153

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 445931023 163 VQAVYGVPASWKLRGQLNFGSIEAETGEKEFMNDDDRFK 201
Cdd:cd02140  154 VAKKWNIPSNWKLRAQLVFGSPEAPPGEKTFIPDEDRVK 192
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-182 8.18e-20

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 82.05  E-value: 8.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023    7 LKNRRSIYALgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDEV-TKFWDELVANDLVETMKVQGAPETAIAG 85
Cdd:pfam00881   1 IRQRRSVRKF-DPEPVPKEVLEEIL-EAARRAPSAGNLQPWRFYVVTDGELrYRLAEAALELLLVEPAAALLLLLRRDAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   86 TKEKLASFGASKGTVLFfedqdVVKSLQEQFVLYADNFPVWSEQSTGIASVNTWTALsAELGLGGNLQHYNPviDASVQA 165
Cdd:pfam00881  79 LKLLLQDFLRGAPVLIV-----ITASLSTYLRKAAERAYREALLDAGAAAQNLLLAA-TSLGLGSCPIGGFD--AAAVRE 150

                         170
                  ....*....|....*..
gi 445931023  166 VYGVPASWKLRGQLNFG 182
Cdd:pfam00881 151 LLGLPDDERLVGLIAVG 167
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-182 1.51e-15

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 70.02  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   7 LKNRRSIYALgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDEvtkfwdelvandlvetmkvqgapetaiagT 86
Cdd:cd02062    1 IKTRRSIRKF-TDKPVPEEKLRKIL-EAARLAPSAGNLQPWRFIVVRDRE-----------------------------K 49

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  87 KEKLASFGASKG--------TVLFFEDQDVVKSlqeqfvlyadnfpvWSEQSTGIASVNTWTALsAELGLGGNLQHYNPV 158
Cdd:cd02062   50 KEKLAKLAAPNQkfiagapvVIVVVADPDKSRP--------------WALEDAGAAAQNLLLAA-AALGLGSCWIGGFDF 114

                        170       180
                 ....*....|....*....|....
gi 445931023 159 IDASVQAVYGVPASWKLRGQLNFG 182
Cdd:cd02062  115 REDKVRELLGIPENLRPVALIAIG 138
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-182 6.43e-11

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 58.33  E-value: 6.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   3 FLEELKNRRSIYALgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDEvtkfwdelvandlvetmkvqgapeta 82
Cdd:COG0778    1 LLELLLTRRSVRKF-TDKPVSDEELEELL-EAARLAPSAGNLQPWRFVVVRDPE-------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023  83 iagTKEKLASFGASKGtvlffedQDVVKSLQEQFVLYAD------NFPVWSEQSTGIASVNTWTALsAELGLGGNLQhyN 156
Cdd:COG0778   53 ---LRERLAEALAEAN-------QEWVADAPVLIVVCADpdrsekVPERYALLDAGIAAQNLLLAA-RALGLGTCWI--G 119

                        170       180
                 ....*....|....*....|....*.
gi 445931023 157 PVIDASVQAVYGVPASWKLRGQLNFG 182
Cdd:COG0778  120 GFDPEKVRELLGLPEGEEPVALLALG 145
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-59 6.75e-07

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 47.08  E-value: 6.75e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 445931023   3 FLEELKNRRSI--YalgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVIlLNDEVTK 59
Cdd:cd02139    1 VYEAIKKRRSIrkY---KPTPVEEEKLLRIL-EAARLAPSAKNRQPWRFIV-VKDKELK 54
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 3-59 4.46e-06

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 44.93  E-value: 4.46e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 445931023   3 FLEELKNRRSIYALGRNTEVSDEKIvEIIKEAVRQSPSAFNSQTSRVVILLNDEVTK 59
Cdd:cd02149    2 ILELLNFRYATKKFDPNKKISDEDL-ETILEALRLSPSSFGLEPWKFLVVENPELKA 57
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 4-56 5.22e-06

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 44.54  E-value: 5.22e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 445931023   4 LEELKNRRSIYALGRNTEVSDEKIVEIIKEAvRQSPSAFNSQTSRVVILLNDE 56
Cdd:cd02137    1 LEVIKSRRSVRNFDPDHKIPKEELKEILELA-TLAPSSFNLQPWRFVVVRDPE 52
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 6-66 1.11e-05

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 44.07  E-value: 1.11e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 445931023   6 ELKNRRSIYALGrNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDevTKFWDELVA 66
Cdd:cd02138    1 LIAERWSPRAFS-PEPISEEDLLSLF-EAARWAPSCFNEQPWRFVVARRD--TEAFEKLLD 57
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 7-52 4.10e-05

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 42.19  E-value: 4.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 445931023   7 LKNRRSIYALgRNTEVSDEKIVEIIKEAvRQSPSAFNSQTSRVVIL 52
Cdd:cd02136    2 IKSRRSVRAF-KDKPVPKETIEKILEAA-RRAPSGKNTQPWRVYVV 45
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 2-56 1.12e-04

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 40.83  E-value: 1.12e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 445931023   2 SFLEELKNRRSIyalgRN---TEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDE 56
Cdd:cd20609    1 DFLELAKKRYSV----RKfsdKPVEKEKLDKIL-EAGRLAPTAVNYQPQRILVVRSEE 53
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 7-74 3.33e-04

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 39.76  E-value: 3.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445931023   7 LKNRRSI--YalgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDEVTKFWDELVandlVETMK 74
Cdd:cd02143    2 LRSRRSIrrY---KDKPVPRETLEKLL-DIARYAPTGHNSQPVHWLVVDDPEKVRRLAELV----IDWMR 63
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 4-59 6.75e-04

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 38.47  E-value: 6.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 445931023   4 LEELKNRRSIYALgRNTEVSDEKIvEIIKEAVRQSPSAFNSQTSRVVILLNDEVTK 59
Cdd:cd20608    1 FEAIKTRRSVRRF-SDKPVEEEKL-EKILEAARLAPSWANKQCWRFIVVTDKETLS 54
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 5-57 1.11e-03

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 38.45  E-value: 1.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 445931023   5 EELKNRRSIYALgRNTEVSDEKIVEIIkEAVRQSPSAFNSQTSRVVILLNDEV 57
Cdd:cd03370    3 EAIESRRSIRKY-TQEPVPDEDLREIL-RLAGLAPSAWNIQPWRFVVVRDAEL 53
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-67 7.43e-03

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 35.72  E-value: 7.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445931023   7 LKNRRSI--YalgRNTEVSDEKIVEIIKEAVRqSPSAFNSQTSRVVILLNDEvtkfWDELVAN 67
Cdd:cd20610    1 IKKRRSIrkF---KPDPVPKEDIEKILEAANW-APSGMNRQNWEFVVVKGGE----KIEKIGI 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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