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Conserved domains on  [gi|446146804|ref|WP_000224659|]
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MULTISPECIES: carbohydrate ABC transporter permease [Enterobacteriaceae]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-280 5.91e-86

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 258.10  E-value: 5.91e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   2 ATNKRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKEAISLHPTLLPQQWTLEHYVDIFNPMifPFVDYFRNSLVVS 81
Cdd:COG0395    6 RRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDG--PFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  82 VVSSVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFML 161
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 162 KSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPD 241
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446146804 242 YIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG 280
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-280 5.91e-86

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 258.10  E-value: 5.91e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   2 ATNKRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKEAISLHPTLLPQQWTLEHYVDIFNPMifPFVDYFRNSLVVS 81
Cdd:COG0395    6 RRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDG--PFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  82 VVSSVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFML 161
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 162 KSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPD 241
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446146804 242 YIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG 280
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
16-280 2.25e-36

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 131.37  E-value: 2.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  16 GLALFLIITLFPFFVMLMTSFKGAKEAISlhpTLLPQQWTLEHY-----VDIFN------PMIFPFVDYFRNSLVVSVVS 84
Cdd:PRK10998  19 LLLGFIALIMFPLLMVIAISLREGNFATG---SLIPEQISWEHWklalgFSVEHadgrvtPPPFPVLLWLWNSVKVAGIT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  85 SVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIY------DTEMALIITMVTqTLPTAV 158
Cdd:PRK10998  96 AIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQYipfiglNTHGGVIFAYLG-GIALHV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 159 FMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFS 238
Cdd:PRK10998 175 WTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQYLN 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446146804 239 TPDYIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG 280
Cdd:PRK10998 255 PQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-259 1.13e-12

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 64.99  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  90 FLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTE----MALIITMVTQTLPTAVFMLKSYF 165
Cdd:cd06261   17 VLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglgLPALILALLLIAPFARLIRRAAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 166 DTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPDYIWG 245
Cdd:cd06261   97 ESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLG 176

                        170
                 ....*....|....
gi 446146804 246 RMMAASLVTALPVV 259
Cdd:cd06261  177 VAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 93-264 5.83e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.01  E-value: 5.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   93 ILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSYFDTIPDEI 172
Cdd:pfam00528   3 PLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  173 EEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSasnftlpVGLNALFSTPdyIWGRMMAASL 252
Cdd:pfam00528  83 VEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW-------PGLGLLLIEA--ILGYDYPEIQ 153

                         170
                  ....*....|..
gi 446146804  253 VTALPVVIMYAL 264
Cdd:pfam00528 154 GPVLAAALILLL 165
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-280 5.91e-86

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 258.10  E-value: 5.91e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   2 ATNKRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKEAISLHPTLLPQQWTLEHYVDIFNPMifPFVDYFRNSLVVS 81
Cdd:COG0395    6 RRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDG--PFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  82 VVSSVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFML 161
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 162 KSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPD 241
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446146804 242 YIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG 280
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 5-280 9.69e-73

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 224.65  E-value: 9.69e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   5 KRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKEAISLhpTLLPQQWTLEHYVDIFNPmiFPFVDYFRNSLVVSVVS 84
Cdd:COG3833   10 RRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSS--SLIPENFTLENYKKLFTE--TPFLRWFLNSLIVAVVT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  85 SVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSY 164
Cdd:COG3833   86 AIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLMKGY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 165 FDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTP-DYI 243
Cdd:COG3833  166 FDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQrNTN 245

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 446146804 244 WGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG 280
Cdd:COG3833  246 WGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
16-280 2.25e-36

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 131.37  E-value: 2.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  16 GLALFLIITLFPFFVMLMTSFKGAKEAISlhpTLLPQQWTLEHY-----VDIFN------PMIFPFVDYFRNSLVVSVVS 84
Cdd:PRK10998  19 LLLGFIALIMFPLLMVIAISLREGNFATG---SLIPEQISWEHWklalgFSVEHadgrvtPPPFPVLLWLWNSVKVAGIT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  85 SVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIY------DTEMALIITMVTqTLPTAV 158
Cdd:PRK10998  96 AIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQYipfiglNTHGGVIFAYLG-GIALHV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 159 FMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFS 238
Cdd:PRK10998 175 WTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQYLN 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446146804 239 TPDYIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGGVKG 280
Cdd:PRK10998 255 PQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 5-272 1.32e-29

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 112.51  E-value: 1.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   5 KRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKeaislHPTLLPQQWTLEHYVDIFNpmIFPFVDYFRNSLVVSVVS 84
Cdd:COG1177    1 SSRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSW-----FLTFPPEGFTLRWYAELFS--DPRLLDALLNSLLIALLS 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  85 SVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSY 164
Cdd:COG1177   74 TLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLAR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 165 FDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFaSIFLSSASNFTLPVGLNALFSTpdYIW 244
Cdd:COG1177  154 LQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVI-TLFLAGPGVTTLPVYIYSMIRR--GIS 230

                        250       260
                 ....*....|....*....|....*...
gi 446146804 245 GRMMAASLVTALPVVIMYALSERFIKSG 272
Cdd:COG1177  231 PEINALSTLLILLSLLLLLLAERLRRRG 258
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
10-267 1.97e-19

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 87.52  E-value: 1.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  10 RIGFYCGLALFLIITLFPFFVMLMTSFKGAkeaislhptlLPQQWTLEHYVDIFNPmiFPFVDYFRNSLVVSVVSSVVAV 89
Cdd:COG1178  288 WLALALCLLLVLLGLLLPLLALLLWSLTKA----------LDDNLTLDNYRFVLLD--PSLLRALLNSLLLALLAALLAV 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  90 FLGILGAYALSRLRFKGRMTINASFYTVYMFSGILL---VVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSYFD 166
Cdd:COG1178  356 LLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLglgLLLLFNRPLPLLLYGTLAILVLAYVVRFLPFALRSLEAALA 435

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 167 TIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDyLFASIFLSSASNFTLPVGLNALFSTPDYiwGR 246
Cdd:COG1178  436 QIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKE-LSATLLLRPPGFETLAVLIYQLASSGRY--GE 512

                        250       260
                 ....*....|....*....|....*
gi 446146804 247 MMAASL----VTALPVVIMYALSER 267
Cdd:COG1178  513 AAALALllvlVSLLPVLLLERLLGR 537
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
17-273 4.21e-18

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 81.71  E-value: 4.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  17 LALFLIITLFPFFVMLMTSFKGAKEAISLHPTLLPQQWTLEHYVDIF----NPMIFPFVDYFRNSLVVSVVSSVVAVFLG 92
Cdd:PRK10973  16 LILGIAVILFPLYVAFVAATLDKQAVFAVPMTLIPGTHLLENIANIWvngvGNNSAPFGRMLLNSFVMAFSITVGKITVS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  93 ILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTlpTAVFMLKSYFDTIPDEI 172
Cdd:PRK10973  96 MLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASA--TATFLFRQFFMTLPDEL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 173 EEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPDYI--WGRMMAA 250
Cdd:PRK10973 174 VEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGTteWNQVMAA 253

                        250       260
                 ....*....|....*....|...
gi 446146804 251 SLVTALPVVIMYALSERFIKSGL 273
Cdd:PRK10973 254 MLLTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-259 1.13e-12

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 64.99  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  90 FLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTE----MALIITMVTQTLPTAVFMLKSYF 165
Cdd:cd06261   17 VLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILpglgLPALILALLLIAPFARLIRRAAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 166 DTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSASNFTLPVGLNALFSTPDYIWG 245
Cdd:cd06261   97 ESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLG 176

                        170
                 ....*....|....
gi 446146804 246 RMMAASLVTALPVV 259
Cdd:cd06261  177 VAAAVALILLLLSL 190
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 1-277 2.30e-12

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 65.55  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   1 MATNKRTLSRIGFYCGLALFLIITLF--PFFVMLMTSFKGAKEAISLHPTllpqqWTLEHYVDIF-NPMifpFVDYFRNS 77
Cdd:COG1176    1 MSAALRRRLRPLLLLLPALLWLLLFFvlPLLLLLVYSFTTRDPYGGVVPG-----FTLENYARLFtDPL---YLKVLLRT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  78 LVVSVVSSVVAVFLGILGAYALSRLRFKGRMTInASFYTVYMFSGILLVVPLFKII-----------TALGIYD------ 140
Cdd:COG1176   73 LWIALLTTLICLLLGYPIAYFLARAPPRWRNLL-LLLVILPFWTSFLVRTYAWIVLlgrngllnsllLALGLIDeplrll 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 141 -TEMALIITMVTQTLPTAVFMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASI 219
Cdd:COG1176  152 yTEFAVVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPAL 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446146804 220 fLSSASNFTLPVGLNALFSTpDYIWGRMMAASLVTALPVVIMYALSERFIKSGLTAGG 277
Cdd:COG1176  232 -LGGGKVLMIGNLIYQQFLS-ALNWPLAAALAVVLLLIVLLVLLLYLRLLRRRRLLGG 287
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 93-264 5.83e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.01  E-value: 5.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   93 ILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSYFDTIPDEI 172
Cdd:pfam00528   3 PLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  173 EEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSasnftlpVGLNALFSTPdyIWGRMMAASL 252
Cdd:pfam00528  83 VEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSW-------PGLGLLLIEA--ILGYDYPEIQ 153

                         170
                  ....*....|..
gi 446146804  253 VTALPVVIMYAL 264
Cdd:pfam00528 154 GPVLAAALILLL 165
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
1-270 2.79e-10

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 60.56  E-value: 2.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804   1 MATNKRTLSRIGFYCGLALFLIITLFPFFVMLMTSFKGAKEAISLHptllpqqwtlehyvdIFNPMifpFVDYFRNSLVV 80
Cdd:COG1178    1 MSTRPRRRPRLLLLLLALLLALLVLLPLLALLLRAFTDGLANFWAL---------------LSDPY---LWRALGNTLLL 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  81 SVVSSVVAVFLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVV----------PLFKIITA-LGIYDTEM----AL 145
Cdd:COG1178   63 ALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALawialfgpngLLNTLLRAlFGLEPPDIyglgGI 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 146 IITMVTQTLPTAVFMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASIFLSSAS 225
Cdd:COG1178  143 ILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVLGGGYT 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 446146804 226 nfTLPVGL-NALFSTPDYiwGRMMAASLVTALPVVIMYALSERFIK 270
Cdd:COG1178  223 --TLTTAIyQAWLGDFDL--GAAAALALVLLLLVLLLLLLERRLRR 264
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
17-221 5.44e-09

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 55.91  E-value: 5.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  17 LALFLIITLFPFFVMLMTSFkgakeaisLHPTLLPQQWT---LEHYVDIF-NPMifpFVDYFRNSLVVSVVSSVVAVFLG 92
Cdd:COG1175   28 LLLLLVFVLYPLLYTLYLSF--------TDWNLLGPPPEfvgLDNYARLFtDPR---FWNALGNTLLFTVVSVPLQLVLG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  93 ILGAYALSRlRFKGRMTINASFYTVYMFSGILLVV-----------PLFKIITALGI------YDTEMAL---IITMVTQ 152
Cdd:COG1175   97 LLLALLLNR-KLRGRGFFRTLFFLPWVISPVVVALiwkwlfnpdygLLNALLGALGLepinwlGDPSLALpavIIVTVWK 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446146804 153 TLPTAVFMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNdyLFASIFL 221
Cdd:COG1175  176 GTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQ--VFDLVYV 242
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 10-230 1.14e-08

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 54.61  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  10 RIGFYCGLALFLIItlfPFFVMLMTSFKGAKEAISLhptllpQQWTLEHYVDIFNPMifPFVDYFRNSLVVSVVSSVVAV 89
Cdd:PRK09500   6 RGGFMTLVYAYLYI---PIIILIVNSFNSSRFGINW------KGFTTKWYELLFNND--SLLQAAQHSLTMAVFSATFAT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804  90 FLGILGAYALSRLRFKGRMTINASFYTVYMFSGILLVVPLFKIITALGIYDTEMALIITMVTQTLPTAVFMLKSYFDTIP 169
Cdd:PRK09500  75 LIGSLTAVALYRYRFRGKKFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFAHITFCLPFVVVTVYSRLKGFD 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446146804 170 DEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASiFLSSASNFTLP 230
Cdd:PRK09500 155 VRMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSFTLSLDDVVVSS-FVTGPSYEILP 214
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 132-201 1.48e-03

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 39.29  E-value: 1.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 132 IITALGIYDTEMALIITMVTQTLPTAVFMLKSYFDTIPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLIS 201
Cdd:PRK09497 140 IDTPIRIMFTESAVIIGLVYILLPFMVLPLYSSIEKLDKPLLEAARDLGANKLQTFIRIIIPLTMPGIIA 209
malF PRK10999
maltose ABC transporter permease MalF;
168-221 2.43e-03

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 39.17  E-value: 2.43e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446146804 168 IPDEIEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFmvAWNDYLFASIFL 221
Cdd:PRK10999 401 IPDDLYEASAMDGAGPFQNFFKITLPLLIKPLTPLMIASF--AFNFNNFVLIQL 452
PRK10592 PRK10592
putrescine transporter subunit: membrane component of ABC superfamily; Provisional
 172-231 8.99e-03

putrescine transporter subunit: membrane component of ABC superfamily; Provisional


Pssm-ID: 182574  Cd Length: 281  Bit Score: 37.14  E-value: 8.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446146804 172 IEEAAMMDGLNRLQIIFRITVPLAMSGLISVFVYCFMVAWNDYLFASiFLSSASNFTLPV 231
Cdd:PRK10592 170 IEEAAMDLGATPLKVFFVITLPMIMPAIISGWLLAFTLSLDDLVIAS-FVSGPGATTLPM 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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