NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446209481|ref|WP_000287336|]
View 

MULTISPECIES: ankyrin repeat domain-containing protein [Bacillus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
81-280 7.95e-46

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 156.27  E-value: 7.95e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  81 NLMDKQLLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREG 160
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 161 YTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLL 240
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAA-----ENGHLEIVKLL 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446209481 241 IDHGADVNMANKEHLTPLQYAEKRGFKDIVNMLRVAGANE 280
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
81-280 7.95e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 156.27  E-value: 7.95e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  81 NLMDKQLLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREG 160
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 161 YTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLL 240
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAA-----ENGHLEIVKLL 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446209481 241 IDHGADVNMANKEHLTPLQYAEKRGFKDIVNMLRVAGANE 280
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 97-280 2.56e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 90.11  E-value: 2.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  97 ETAMKLIQDGANINVEGDNGETPVLAA--TYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTD--IVKVLINAG 172
Cdd:PHA03100  87 EIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKG 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 173 VNTKETTRsggtalisaserghvevVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLIDHGADVNMANK 252
Cdd:PHA03100 167 VDINAKNR-----------------VNYLLSY-GVPINIKDVYGFTPLHYAV-----YNNNPEFVKYLLDLGANPNLVNK 223

                        170       180
                 ....*....|....*....|....*...
gi 446209481 253 EHLTPLQYAEKRGFKDIVNMLRVAGANE 280
Cdd:PHA03100 224 YGDTPLHIAILNNNKEIFKLLLNNGPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-251 8.31e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 8.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  153 LLYASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVnykNERGGTALLEAIvlgngSEN 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAA-----RSG 72

                          90
                  ....*....|....*....
gi 446209481  233 HKKVIQLLIDHGADVNMAN 251
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 150-283 9.47e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.09  E-value: 9.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 150 SNPLLYASREGYTDIVKVLI-NAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVN-------YKnerGGTALL 221
Cdd:cd22192   18 ESPLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNepmtsdlYQ---GETALH 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446209481 222 EAIVlgNGSENhkkVIQLLIDHGADVNMA------------NK----EHltPLQYAEKRGFKDIVNMLRVAGANEVVQ 283
Cdd:cd22192   95 IAVV--NQNLN---LVRELIARGADVVSPratgtffrpgpkNLiyygEH--PLSFAACVGNEEIVRLLIEHGADIRAQ 165
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
81-280 7.95e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 156.27  E-value: 7.95e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  81 NLMDKQLLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREG 160
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 161 YTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLL 240
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAA-----ENGHLEIVKLL 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446209481 241 IDHGADVNMANKEHLTPLQYAEKRGFKDIVNMLRVAGANE 280
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
87-279 5.44e-43

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.56  E-value: 5.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  87 LLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVK 166
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 167 VLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLIDHGAD 246
Cdd:COG0666  171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAA-----ENGNLEIVKLLLEAGAD 244

                        170       180       190
                 ....*....|....*....|....*....|...
gi 446209481 247 VNMANKEHLTPLQYAEKRGFKDIVNMLRVAGAN 279
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
80-248 1.04e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.90  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  80 INLMDKQ----LLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLY 155
Cdd:COG0666  113 VNARDKDgetpLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 156 ASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIVLGNGSENHKK 235
Cdd:COG0666  193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA-GADLNAKDKDGLTALLLAAAAGAALIVKLL 271

                        170
                 ....*....|...
gi 446209481 236 VIQLLIDHGADVN 248
Cdd:COG0666  272 LLALLLLAAALLD 284
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 97-280 2.56e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 90.11  E-value: 2.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  97 ETAMKLIQDGANINVEGDNGETPVLAA--TYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTD--IVKVLINAG 172
Cdd:PHA03100  87 EIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKG 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 173 VNTKETTRsggtalisaserghvevVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLIDHGADVNMANK 252
Cdd:PHA03100 167 VDINAKNR-----------------VNYLLSY-GVPINIKDVYGFTPLHYAV-----YNNNPEFVKYLLDLGANPNLVNK 223

                        170       180
                 ....*....|....*....|....*...
gi 446209481 253 EHLTPLQYAEKRGFKDIVNMLRVAGANE 280
Cdd:PHA03100 224 YGDTPLHIAILNNNKEIFKLLLNNGPSI 251
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
80-215 3.41e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 3.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  80 INLMDKQ----LLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLY 155
Cdd:COG0666  146 VNAQDNDgntpLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 156 ASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVNYKNER 215
Cdd:COG0666  226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-251 8.31e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 8.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  153 LLYASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVnykNERGGTALLEAIvlgngSEN 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAA-----RSG 72

                          90
                  ....*....|....*....
gi 446209481  233 HKKVIQLLIDHGADVNMAN 251
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
123-213 2.37e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.15  E-value: 2.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  123 ATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLIN-AGVNTKEttrSGGTALISASERGHVEVVKEL 201
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNLKD---NGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|..
gi 446209481  202 LEHtDIDVNYKN 213
Cdd:pfam12796  81 LEK-GADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 101-277 1.45e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 101 KLIQDGANINVEGDNGETPV---LAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYT-DIVKVLINAGVNTK 176
Cdd:PHA03095  32 RLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGADVN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 177 ETTRSGGTAL--ISASERGHVEVVKELLEHtDIDVNYKNERGGTALleAIVLGNGSENhKKVIQLLIDHGADVNMANKEH 254
Cdd:PHA03095 112 AKDKVGRTPLhvYLSGFNINPKVIRLLLRK-GADVNALDLYGMTPL--AVLLKSRNAN-VELLRLLIDAGADVYAVDDRF 187

                        170       180
                 ....*....|....*....|....*..
gi 446209481 255 LTPL----QYAEKRgfKDIVNMLRVAG 277
Cdd:PHA03095 188 RSLLhhhlQSFKPR--ARIVRELIRAG 212
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-278 1.49e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.07  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  94 GDTETAMKLIQDGAN-INVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAG 172
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 173 VNTKettrsggTALISASERghvEVVKELLEhTDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLIDHGADVNMANK 252
Cdd:PHA02874  92 VDTS-------ILPIPCIEK---DMIKTILD-CGIDVNIKDAELKTFLHYAI-----KKGDLESIKMLFEYGADVNIEDD 155

                        170       180
                 ....*....|....*....|....*.
gi 446209481 253 EHLTPLQYAEKRGFKDIVNMLRVAGA 278
Cdd:PHA02874 156 NGCYPIHIAIKHNFFDIIKLLLEKGA 181
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-174 1.94e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481   87 LLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIgAGANIEIKDEKKsNPLLYASREGYTDIVK 166
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNGR-TALHYAARSGHLEIVK 78


                  ....*...
gi 446209481  167 VLINAGVN 174
Cdd:pfam12796  79 LLLEKGAD 86
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 95-264 2.09e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.99  E-value: 2.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  95 DTETAMKLIQDGANIN-VEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAGV 173
Cdd:PHA02878 146 EAEITKLLLSYGADINmKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 174 NTKETTRSGGTAL-ISASERGHVEVVKELLEHtDIDVNYKNE-RGGTALLEAIvlgngseNHKKVIQLLIDHGADVNMAN 251
Cdd:PHA02878 226 STDARDKCGNTPLhISVGYCKDYDILKLLLEH-GVDVNAKSYiLGLTALHSSI-------KSERKLKLLLEYGADINSLN 297

                        170
                 ....*....|...
gi 446209481 252 KEHLTPLQYAEKR 264
Cdd:PHA02878 298 SYKLTPLSSAVKQ 310
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 83-262 1.20e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 71.05  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  83 MDKQLLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYT 162
Cdd:PLN03192 525 MASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHH 604

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 163 DIVKVLIN-AGVNTKETtrsGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLI 241
Cdd:PLN03192 605 KIFRILYHfASISDPHA---AGDLLCTAAKRNDLTAMKELLKQ-GLNVDSEDHQGATALQVAM-----AEDHVDMVRLLI 675

                        170       180
                 ....*....|....*....|..
gi 446209481 242 DHGADVNMAN-KEHLTPLQYAE 262
Cdd:PLN03192 676 MNGADVDKANtDDDFSPTELRE 697
PHA03095 PHA03095
ankyrin-like protein; Provisional
 129-280 1.87e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.05  E-value: 1.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 129 VETVKALIGAGANIEIKDEKKSNPL---LYASREGYTDIVKVLINAG--VNTKEttRSGGTALI----SASErghVEVVK 199
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGadVNAPE--RCGFTPLHlylyNATT---LDVIK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 200 ELLEHtDIDVNYKNERGGTALleAIVLGNGSeNHKKVIQLLIDHGADVNMANKEHLTPLQ-YAEKRGFK-DIVNMLRVAG 277
Cdd:PHA03095 102 LLIKA-GADVNAKDKVGRTPL--HVYLSGFN-INPKVIRLLLRKGADVNALDLYGMTPLAvLLKSRNANvELLRLLIDAG 177


                 ...
gi 446209481 278 ANE 280
Cdd:PHA03095 178 ADV 180
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 79-288 2.36e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.09  E-value: 2.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  79 SINLMDKQLLLSATLGDTETAM----------------------------------KLIQDGANINVEGDNGETPV-LAA 123
Cdd:PHA02876 236 NINKNDLSLLKAIRNEDLETSLllydagfsvnsiddckntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLyLMA 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 124 TYQNHVETVKALIGAGANIEIKDEKKSNPLLYASR-EGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELL 202
Cdd:PHA02876 316 KNGYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 203 EHtDIDVNYKNERGGTALLEAIVlgngSENHKKVIQLLIDHGADVNMANKEHLTPLQYAEKRGFK-DIVNMLRVAGA--N 279
Cdd:PHA02876 396 DY-GADIEALSQKIGTALHFALC----GTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEMLLDNGAdvN 470

                        250
                 ....*....|
gi 446209481 280 EV-VQPQQPV 288
Cdd:PHA02876 471 AInIQNQYPL 480
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 95-273 1.29e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  95 DTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAGVN 174
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 175 TKETTRSGGTALISASERGHVEVVKELLEHTDiDVNYKNERGGTALLEAIVlgngseNHKKVIQLLIDHgADVNMANKEH 254
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAII------HNRSAIELLINN-ASINDQDIDG 254

                        170       180
                 ....*....|....*....|
gi 446209481 255 LTPLQYA-EKRGFKDIVNML 273
Cdd:PHA02874 255 STPLHHAiNPPCDIDIIDIL 274
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-261 1.61e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.36  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  94 GDTETAMK-LIQDGANINVEGDNGETP--VLAATYQNHVETVKALIGAGANIEIKDEKKSNPL--LYASREGYTDIVKVL 168
Cdd:PHA03095  94 ATTLDVIKlLIKAGADVNAKDKVGRTPlhVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 169 INAGVNTKETTRSGGTAL--ISASERGHVEVVKELLEHtDIDVNYKNERGGTALLeaiVLGNGSENHKKVIQLLIDHGAD 246
Cdd:PHA03095 174 IDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELIRA-GCDPAATDMLGNTPLH---SMATGSSCKRSLVLPLLIAGIS 249

                        170
                 ....*....|....*
gi 446209481 247 VNMANKEHLTPLQYA 261
Cdd:PHA03095 250 INARNRYGQTPLHYA 264
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-278 1.47e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.70  E-value: 1.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  95 DTETAMKLIQDGANINVEGDNGETPV-LAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAGV 173
Cdd:PHA02876 320 DTENIRTLIMLGADVNAADRLYITPLhQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 174 NTKETTRSGGTAL-ISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSENHK-KVIQLLIDHGADVNMAN 251
Cdd:PHA02876 400 DIEALSQKIGTALhFALCGTNPYMSVKTLIDR-GANVNSKNKDLSTPLHYAC-----KKNCKlDVIEMLLDNGADVNAIN 473

                        170       180
                 ....*....|....*....|....*..
gi 446209481 252 KEHLTPLQYAekRGFKDIVNMLRVAGA 278
Cdd:PHA02876 474 IQNQYPLLIA--LEYHGIVNILLHYGA 498
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 90-279 1.80e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.31  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  90 SATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIeikdEKKSNPLLYASREGYTDIVKVLI 169
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI----NKNDLSLLKAIRNEDLETSLLLY 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 170 NAGVNTKETTRSGGTALISASERGHV-EVVKELLEHtDIDVNYKNERGGTALLEAIVLGNGSENhkkvIQLLIDHGADVN 248
Cdd:PHA02876 261 DAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLER-GADVNAKNIKGETPLYLMAKNGYDTEN----IRTLIMLGADVN 335

                        170       180       190
                 ....*....|....*....|....*....|..
gi 446209481 249 MANKEHLTPLQYAEKRG-FKDIVNMLRVAGAN 279
Cdd:PHA02876 336 AADRLYITPLHQASTLDrNKDIVITLLELGAN 367
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 86-214 3.20e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 3.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  86 QLLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVET------------------VKALIGAGANIEIKDE 147
Cdd:PHA03100 111 LYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDV 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446209481 148 KKSNPLLYASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDiDVNYKNE 214
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP-SIKTIIE 256
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-270 3.74e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.06  E-value: 3.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  94 GDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAGV 173
Cdd:PHA02874 135 GDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGN 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 174 NTKETTRSGGTALISA--SERGHVEVVKELLEHTDIDVNyknerGGTALLEAIvlgnGSENHKKVIQLLIDHGADVNMAN 251
Cdd:PHA02874 215 HIMNKCKNGFTPLHNAiiHNRSAIELLINNASINDQDID-----GSTPLHHAI----NPPCDIDIIDILLYHKADISIKD 285

                        170
                 ....*....|....*....
gi 446209481 252 KEHLTPLQYAEKRGFKDIV 270
Cdd:PHA02874 286 NKGENPIDTAFKYINKDPV 304
PHA03095 PHA03095
ankyrin-like protein; Provisional
 102-261 1.41e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.50  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 102 LIQDGANINVEGDNGETPV-LAATYQNHVETVKALIGAGANIEIKDEKKSNPL-LYASREG-YTDIVKVLINAGVNTKET 178
Cdd:PHA03095  69 LLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLhVYLSGFNiNPKVIRLLLRKGADVNAL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 179 TRSGGT---ALISaSERGHVEVVKELLEHtDIDVNYKNERGGTALLeaiVLGNGSENHKKVIQLLIDHGADVNMANKEHL 255
Cdd:PHA03095 149 DLYGMTplaVLLK-SRNANVELLRLLIDA-GADVYAVDDRFRSLLH---HHLQSFKPRARIVRELIRAGCDPAATDMLGN 223


                 ....*.
gi 446209481 256 TPLQYA 261
Cdd:PHA03095 224 TPLHSM 229
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 83-279 2.80e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 2.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  83 MDKQLLLSA-TLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGY 161
Cdd:PHA02875   1 MDQVALCDAiLFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 162 TDIVKVLINAGVNTKETT-RSGGTALISASERGHVEVVKELLEH-TDIDVNykNERGGTALLEAIVLGNgsenhKKVIQL 239
Cdd:PHA02875  81 VKAVEELLDLGKFADDVFyKDGMTPLHLATILKKLDIMKLLIARgADPDIP--NTDKFSPLHLAVMMGD-----IKGIEL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446209481 240 LIDHGADVNMANKEHLTPLQYAEKRGFKDIVNMLRVAGAN 279
Cdd:PHA02875 154 LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 94-256 1.16e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.38  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  94 GDTETAMKLIQDGANIN-VEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAG 172
Cdd:PHA02875  79 GDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 173 VNTKETTRSGGTALISASERGHVEVVKELLEhTDIDVNYKNERGGTALLEAIVlgngSENHKKVIQLLIDHGADVNMA-- 250
Cdd:PHA02875 159 ACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALCYAI----ENNKIDIVRLFIKRGADCNIMfm 233


                 ....*...
gi 446209481 251 --NKEHLT 256
Cdd:PHA02875 234 ieGEECTI 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
80-186 1.60e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  80 INLMDKQ----LLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLY 155
Cdd:COG0666  179 VNARDNDgetpLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446209481 156 ASREGYTDIVKVLINAGVNTKETTRSGGTAL 186
Cdd:COG0666  259 AAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_4 pfam13637
Ankyrin repeats (many copies);
150-202 4.66e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 4.66e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446209481  150 SNPLLYASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELL 202
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 150-283 9.47e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.09  E-value: 9.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 150 SNPLLYASREGYTDIVKVLI-NAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVN-------YKnerGGTALL 221
Cdd:cd22192   18 ESPLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNepmtsdlYQ---GETALH 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446209481 222 EAIVlgNGSENhkkVIQLLIDHGADVNMA------------NK----EHltPLQYAEKRGFKDIVNMLRVAGANEVVQ 283
Cdd:cd22192   95 IAVV--NQNLN---LVRELIARGADVVSPratgtffrpgpkNLiyygEH--PLSFAACVGNEEIVRLLIEHGADIRAQ 165
Ank_4 pfam13637
Ankyrin repeats (many copies);
216-273 1.15e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 1.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446209481  216 GGTALLEAIVlgngsENHKKVIQLLIDHGADVNMANKEHLTPLQYAEKRGFKDIVNML 273
Cdd:pfam13637   1 ELTALHAAAA-----SGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
182-241 2.79e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 2.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  182 GGTALISASERGHVEVVKELLEHTdIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLI 241
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAA-----SNGNVEVLKLLL 54
PHA02798 PHA02798
ankyrin-like protein; Provisional
 102-273 6.07e-07

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.22  E-value: 6.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 102 LIQDGANINVEGDNGETPVLA-----ATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYT---DIVKVLINAGV 173
Cdd:PHA02798  57 FINLGANVNGLDNEYSTPLCTilsniKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYInnlEILLFMIENGA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 174 NTKETTRSGGTALISASERGH---VEVVKELLEhTDIDVNYKNERGGTALLEAIVLGNGSENHKKVIQLLIDHGADVNMA 250
Cdd:PHA02798 137 DTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLE-KGVDINTHNNKEKYDTLHCYFKYNIDRIDADILKLFVDNGFIINKE 215

                        170       180       190
                 ....*....|....*....|....*....|
gi 446209481 251 NKEH-------LTPLQYAEKRGFKDIVNML 273
Cdd:PHA02798 216 NKSHkkkfmeyLNSLLYDNKRFKKNILDFI 245
Ank_5 pfam13857
Ankyrin repeats (many copies);
201-261 4.95e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 4.95e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446209481  201 LLEHTDIDVNYKNERGGTALLEAIvLGNGSEnhkkVIQLLIDHGADVNMANKEHLTPLQYA 261
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAA-KYGALE----IVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 102-271 5.29e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 47.43  E-value: 5.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 102 LIQDGANINVEGDNGETPVLAATYQNHVETV---KALIGAGANI-EIKDEKKSNpLLYASREGY---TDIVKVLINAGVN 174
Cdd:PHA02989  94 LLKFGADINLKTFNGVSPIVCFIYNSNINNCdmlRFLLSKGINVnDVKNSRGYN-LLHMYLESFsvkKDVIKILLSFGVN 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 175 TKETTRSGGTALISASERGHVEVV----------------------KELLE---------HTD-----------IDVNYK 212
Cdd:PHA02989 173 LFEKTSLYGLTPMNIYLRNDIDVIsikvikylikkgvnietnnngsESVLEsfldnnkilSKKefkvlnfilkyIKINKK 252

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446209481 213 NERGGTALLEAIVLGNGSenhkkVIQLLIDHGADVNMANKEHLTPLQYAEKRGFKDIVN 271
Cdd:PHA02989 253 DKKGFNPLLISAKVDNYE-----AFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLN 306
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 193-284 5.38e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 5.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 193 GHVEVVKELLEHTDIDVNYKNERGGTALLEAIVLGNGsenhkKVIQLLIDHGADVNMANKEHLTPLQYAEKRGFKDIVNM 272
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDA-----KIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKL 86

                         90
                 ....*....|..
gi 446209481 273 LRVAGANEVVQP 284
Cdd:PHA02874  87 LIDNGVDTSILP 98
PHA02798 PHA02798
ankyrin-like protein; Provisional
 162-259 6.52e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.14  E-value: 6.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 162 TDIVKVLINAG--VNTKETTRSGG--TALISASERGH-VEVVKELLEHtDIDVNYKNERGGTALLeaIVLGNGSENHKKV 236
Cdd:PHA02798  51 TDIVKLFINLGanVNGLDNEYSTPlcTILSNIKDYKHmLDIVKILIEN-GADINKKNSDGETPLY--CLLSNGYINNLEI 127

                         90       100
                 ....*....|....*....|...
gi 446209481 237 IQLLIDHGADVNMANKEHLTPLQ 259
Cdd:PHA02798 128 LLFMIENGADTTLLDKDGFTMLQ 150
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-146 9.61e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 9.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481   87 LLLSATLGDTETAMKLIqDGANINVEgDNGETPVLAATYQNHVETVKALIGAGANIEIKD 146
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLL-EHADVNLK-DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
91-136 1.27e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 1.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446209481   91 ATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALI 136
Cdd:pfam13637   9 AASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 87-238 1.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.75  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  87 LLLSATLGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVK 166
Cdd:PHA02875 106 LHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICK 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 167 VLINAGVNTKETTRSGG-TALISASERGHVEVVKELL---------------EHT------DIDVNYKNERGGtALLEAI 224
Cdd:PHA02875 186 MLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIkrgadcnimfmiegeECTildmicNMCTNLESEAID-ALIADI 264

                        170
                 ....*....|....
gi 446209481 225 VLgngsENHKKVIQ 238
Cdd:PHA02875 265 AI----RIHKKTIR 274
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 195-279 2.92e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.04  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 195 VEVVKELLEH-TDIDVNYKNERGGTALLEAIVLgngSENH-KKVIQLLIDHGADVNMANKEHLTPLQYA--EKRGFKDIV 270
Cdd:PHA03100  48 IDVVKILLDNgADINSSTKNNSTPLHYLSNIKY---NLTDvKEIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIV 124


                 ....*....
gi 446209481 271 NMLRVAGAN 279
Cdd:PHA03100 125 EYLLDNGAN 133
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 119-279 5.91e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.10  E-value: 5.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 119 PVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLInagvnTKETTRSGGTALISASERGH---V 195
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI-----RSINKCSVFYTLVAIKDAFNnrnV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 196 EVVKELL-----EHTDIDVNYKNERGGTALLEAivlgngsenhkKVIQLLIDHGADVNMANKEHL-TPLQYAEKRGFKDI 269
Cdd:PHA02878 115 EIFKIILtnrykNIQTIDLVYIDKKSKDDIIEA-----------EITKLLLSYGADINMKDRHKGnTALHYATENKDQRL 183

                        170
                 ....*....|
gi 446209481 270 VNMLRVAGAN 279
Cdd:PHA02878 184 TELLLSYGAN 193
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 208-273 7.60e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 7.60e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446209481 208 DVNYKNERGGTALLEAIVLGngsenHKKVIQLLIDHGADVNMANKEHLTPLQYAEKRGFKDIVNML 273
Cdd:PTZ00322 107 DPNCRDYDGRTPLHIACANG-----HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_2 pfam12796
Ankyrin repeats (3 copies);
230-273 7.66e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.87  E-value: 7.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446209481  230 SENHKKVIQLLIDHGADVNMANKEHLTPLQYAEKRGFKDIVNML 273
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 89-168 1.38e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481  89 LSATlGDTETAMKLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVL 168
Cdd:PTZ00322  89 LAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA02798 PHA02798
ankyrin-like protein; Provisional
 129-253 1.88e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 42.51  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 129 VETVKALIGAGANIEIKDEKKSNPL--LYASREGYT---DIVKVLINAGVNTKETTRSGGT---ALISASERGHVEVVKE 200
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLctILSNIKDYKhmlDIVKILIENGADINKKNSDGETplyCLLSNGYINNLEILLF 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446209481 201 LLEHtDIDVNYKNERGGTALleAIVLGNGSENHKKVIQLLIDHGADVNMANKE 253
Cdd:PHA02798 131 MIEN-GADTTLLDKDGFTML--QVYLQSNHHIDIEIIKLLLEKGVDINTHNNK 180
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 163-269 2.82e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 42.05  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 163 DIVKVLINAGVNTKETTRS--------------GGTALISASERGHVEVVKELLEHTDIDVNYKNERGGTALLEAIVLGN 228
Cdd:cd22194  155 DIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTDITSQDSRGNTVLHALVTVAE 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446209481 229 GSENHKKVI-----QLLIDHGADV--NMANKEHLTPLQYAEKRGFKDI 269
Cdd:cd22194  235 DSKTQNDFVkrmydMILLKSENKNleTIRNNEGLTPLQLAAKMGKAEI 282
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 115-147 3.69e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 3.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446209481  115 NGETPV-LAATYQNHVETVKALIGAGANIEIKDE 147
Cdd:pfam00023   1 DGNTPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 109-265 6.62e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.19  E-value: 6.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 109 INVEGDNGETPVLAATYQNHV--ETVKALIGAGANIE--IKDEKKSNPLLYAS--REGYTDIVKVLINAGVNTKETTRSG 182
Cdd:PHA02859  44 VNDCNDLYETPIFSCLEKDKVnvEILKFLIENGADVNfkTRDNNLSALHHYLSfnKNVEPEILKILIDSGSSITEEDEDG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 183 GTAL------ISASerghVEVVKELLEHTDIDVNyKNERGGTALLEAIVLgngsENHKKVIQLLIDHGADVNMANKEHLT 256
Cdd:PHA02859 124 KNLLhmymcnFNVR----INVIKLLIDSGVSFLN-KDFDNNNILYSYILF----HSDKKIFDFLTSLGIDINETNKSGYN 194


                 ....*....
gi 446209481 257 PLQYAEKRG 265
Cdd:PHA02859 195 CYDLIKFRN 203
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 154-248 7.95e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 154 LYASREGYTDIVKVLINAGVNTKETTRSggtaLIS-ASERGHVEVVkellehtdIDVNYKNE--RGGTALLEAIvlgngS 230
Cdd:cd22194   88 LTASDTGKTCLMKALLNINENTKEIVRI----LLAfAEENGILDRF--------INAEYTEEayEGQTALNIAI-----E 150

                         90
                 ....*....|....*...
gi 446209481 231 ENHKKVIQLLIDHGADVN 248
Cdd:cd22194  151 RRQGDIVKLLIAKGADVN 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 132-210 8.05e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 8.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446209481 132 VKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVN 210
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA02798 PHA02798
ankyrin-like protein; Provisional
 102-248 8.09e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.59  E-value: 8.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 102 LIQDGANINVEGDNGETPV---LAATYQNHVETVKALIGAGANIEIKDEKKSNPL------------------------- 153
Cdd:PHA02798  95 LIENGADINKKNSDGETPLyclLSNGYINNLEILLFMIENGADTTLLDKDGFTMLqvylqsnhhidieiiklllekgvdi 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 154 -LYASREGYT---------------DIVKVLINAGVNTKETTRSGGT-------ALISASERGHVEVVKELLEHtdIDVN 210
Cdd:PHA02798 175 nTHNNKEKYDtlhcyfkynidridaDILKLFVDNGFIINKENKSHKKkfmeylnSLLYDNKRFKKNILDFIFSY--IDIN 252

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 446209481 211 YKNERGGTALLEAIvlgngSENHKKVIQLLIDHGADVN 248
Cdd:PHA02798 253 QVDELGFNPLYYSV-----SHNNRKIFEYLLQLGGDIN 285
Ank_5 pfam13857
Ankyrin repeats (many copies);
178-223 9.71e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 9.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446209481  178 TTRSGGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEA 223
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
140-189 1.08e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 1.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446209481  140 ANIEIKDEKKSNPLLYASREGYTDIVKVLINAGVNTKETTRSGGTALISA 189
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 102-279 1.50e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.86  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 102 LIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYtdIVKVLINAGVNTKETTRS 181
Cdd:PHA02878  56 LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFNNRNVE--IFKIILTNRYKNIQTIDL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 182 GGTALISASERGHVEVVKELLEHtDIDVNYKNERGGTALLEAIvlgngSEN-HKKVIQLLIDHGADVNMANKEHLTPLQY 260
Cdd:PHA02878 134 VYIDKKSKDDIIEAEITKLLLSY-GADINMKDRHKGNTALHYA-----TENkDQRLTELLLSYGANVNIPDKTNNSPLHH 207

                        170
                 ....*....|....*....
gi 446209481 261 AEKRGFKDIVNMLRVAGAN 279
Cdd:PHA02878 208 AVKHYNKPIVHILLENGAS 226
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 215-252 3.25e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 3.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 446209481  215 RGGTALLEAIvlgnGSENHKKVIQLLIDHGADVNMANK 252
Cdd:pfam00023   1 DGNTPLHLAA----GRRGNLEIVKLLLSKGADVNARDK 34
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 161-249 4.60e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 38.18  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 161 YTDIVKVLINAGVNTKETTRsGGTALISASERGHV--EVVKELLEHTDiDVNYKN--ERGGTALLEAIVLGngSENHKKV 236
Cdd:PHA02989  15 DKNALEFLLRTGFDVNEEYR-GNSILLLYLKRKDVkiKIVKLLIDNGA-DVNYKGyiETPLCAVLRNREIT--SNKIKKI 90

                         90
                 ....*....|...
gi 446209481 237 IQLLIDHGADVNM 249
Cdd:PHA02989  91 VKLLLKFGADINL 103
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 101-273 5.89e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 37.97  E-value: 5.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 101 KLIQDGANINVEGDNGETPVLaaTYQNHVETVKALIGAGANIEIKDEKKSN-PL---LYASREGYTDI--VKVLINAGVN 174
Cdd:PHA02716 232 KIIELGGDMDMKCVNGMSPIM--TYIINIDNINPEITNIYIESLDGNKVKNiPMilhSYITLARNIDIsvVYSFLQPGVK 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 175 TKETTRSGGTALISASERGHV--EVVKELLEHTDiDVNYKNERGGTAL------LEAIVLGNGSENHK---KVIQLLIDH 243
Cdd:PHA02716 310 LHYKDSAGRTCLHQYILRHNIstDIIKLLHEYGN-DLNEPDNIGNTVLhtylsmLSVVNILDPETDNDirlDVIQCLISL 388

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446209481 244 GADVNMANKEHLTPLQ----YAEKRGFKDIVNML 273
Cdd:PHA02716 389 GADITAVNCLGYTPLTsyicTAQNYMYYDIIDCL 422
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 195-279 7.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.74  E-value: 7.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 195 VEVVKELLEHTDIDVNYKNErggTALLEAIVLGNGSENHKKVIQLLIDHGADVNMANKEHLTPLQYAEKRGFKDIVNMLR 274
Cdd:PHA02876 122 IHILKEAISGNDIHYDKINE---SIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLL 198


                 ....*
gi 446209481 275 VAGAN 279
Cdd:PHA02876 199 SYGAD 203
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
163-279 7.90e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 37.24  E-value: 7.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 163 DIVKVLINAGVNTKETTRSGGTALISASERGHVEVVKELLEHTDIDVNYKNERGGTALLEAIvlgngSENHKKVIQLLID 242
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAA-----LAGDLLVALLLLA 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446209481 243 HGADVNMANKEHLTPLQYAEKRGFKDIVNMLRVAGAN 279
Cdd:COG0666   76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD 112
PHA03095 PHA03095
ankyrin-like protein; Provisional
 101-170 8.56e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.31  E-value: 8.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446209481 101 KLIQDGANINVEGDNGETPVLAATYQNHVETVKALIGAGANIEIKDEKKSNPLLYASREGYTDIVKVLIN 170
Cdd:PHA03095 242 PLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH