NCBI Conserved Domain Search

Conserved domains on [gi|446273968|ref|WP_000351823|]

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MULTISPECIES: ABC transporter ATP-binding protein [Bacillus]

Protein Classification

ABC transporter ATP-binding protein( domain architecture ID 11467437)

ABC transporter ATP-binding protein is the ATPase catalytic subunit of an ATP transporter complex responsible for coupling the energy of ATP hydrolysis to the import of one or more from a variety of substrates including Fe(3+) ions and polyamines such as spermidine and putrescine

CATH: 3.40.50.300

EC: 7.-.-.-

Gene Ontology: GO:0042626|GO:0140359|GO:0005524|GO:0016887

PubMed: 25750732|24638992

SCOP: 4003976

TCDB: 3.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PotA

COG3842

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ...

2-317

1.73e-148

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 421.81 E-value: 1.73e-148

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSsakkikTSPHERN 81
Cdd:COG3842    5 ALELENVSKRYGDVTALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFETPDSGRILLDGRDVTG------LPPEKRN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG3842   79 VGMVFQDYALFPHLTVAENVAFGLRMRGVPkAEIRARVAELLELVGLEGLADRYPHQLSGGQQQRVALARALAPEPRVLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:COG3842  159 LDEPLSALDAKLREEMREELRRLQRELGITFIYVTHDQEEALALADRIAVMNDGRIEQVGTPEEIYERPATRFVADFIGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 241 ANWL-------------VEGKQ-----------------MIRPEHVSWTKNEVCEMYTGEIQHVTYVGERYEMKVNMGAL 290
Cdd:COG3842  239 ANLLpgtvlgdegggvrTGGRTlevpadaglaaggpvtvAIRPEDIRLSPEGPENGLPGTVEDVVFLGSHVRYRVRLGDG 318

                        330       340       350
                 ....*....|....*....|....*....|.
gi 446273968 291 GIWTAY----HNSKLSIGKPVSLYVPKKYIH 317
Cdd:COG3842  319 QELVVRvpnrAALPLEPGDRVGLSWDPEDVV 349

Name

Accession

Description

Interval

E-value

PotA

COG3842

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ...

2-317

1.73e-148

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 421.81 E-value: 1.73e-148

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSsakkikTSPHERN 81
Cdd:COG3842    5 ALELENVSKRYGDVTALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFETPDSGRILLDGRDVTG------LPPEKRN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG3842   79 VGMVFQDYALFPHLTVAENVAFGLRMRGVPkAEIRARVAELLELVGLEGLADRYPHQLSGGQQQRVALARALAPEPRVLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:COG3842  159 LDEPLSALDAKLREEMREELRRLQRELGITFIYVTHDQEEALALADRIAVMNDGRIEQVGTPEEIYERPATRFVADFIGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 241 ANWL-------------VEGKQ-----------------MIRPEHVSWTKNEVCEMYTGEIQHVTYVGERYEMKVNMGAL 290
Cdd:COG3842  239 ANLLpgtvlgdegggvrTGGRTlevpadaglaaggpvtvAIRPEDIRLSPEGPENGLPGTVEDVVFLGSHVRYRVRLGDG 318

                        330       340       350
                 ....*....|....*....|....*....|.
gi 446273968 291 GIWTAY----HNSKLSIGKPVSLYVPKKYIH 317
Cdd:COG3842  319 QELVVRvpnrAALPLEPGDRVGLSWDPEDVV 349

ABC_PotA_N

cd03300

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ...

3-239

8.50e-118

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required for homodimerization with PotA and heterdimerization with PotB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213267 [Multi-domain] Cd Length: 232 Bit Score: 339.21 E-value: 8.50e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNI 82
Cdd:cd03300    1 IELENVSKFYGGFVALDGVSLDIKEGEFFTLLGPSGCGKTTLLRLIAGFETPTSGEILLDGKDI------TNLPPHKRPV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRaTKQTNQ--LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:cd03300   75 NTVFQNYALFPHLTVFENIAFGLR-LKKLPKaeIKERVAEALDLVQLEGYANRKPSQLSGGQQQRVAIARALVNEPKVLL 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:cd03300  154 LDEPLGALDLKLRKDMQLELKRLQKELGITFVFVTHDQEEALTMSDRIAVMNKGKIQQIGTPEEIYEEPANRFVADFIG 232

potA

PRK09452

spermidine/putrescine ABC transporter ATP-binding protein PotA;

3-242

6.55e-105

spermidine/putrescine ABC transporter ATP-binding protein PotA;

Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 311.88 E-value: 6.55e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNI 82
Cdd:PRK09452  15 VELRGISKSFDGKEVISNLDLTINNGEFLTLLGPSGCGKTTVLRLIAGFETPDSGRIMLDGQDI------THVPAENRHV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTNQ-LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:PRK09452  89 NTVFQSYALFPHMTVFENVAFGLRMQKTPAAeITPRVMEALRMVQLEEFAQRKPHQLSGGQQQRVAIARAVVNKPKVLLL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGKA 241
Cdd:PRK09452 169 DESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVARFIGEI 248


                 .
gi 446273968 242 N 242
Cdd:PRK09452 249 N 249

PhnT2

TIGR03265

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ...

3-244

4.07e-97

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ATP-binding protein is found in a number of genomes in operon-like contexts strongly suggesting a substrate specificity for 2-aminoethylphosphonate (2-AEP). The characterized PhnSTUV system is absent in the genomes in which this system is found. These genomes encode systems for the catabolism of 2-AEP, making the need for a 2-AEP-specific transporter likely. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 274496 [Multi-domain] Cd Length: 353 Bit Score: 291.17 E-value: 4.07e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGdtcmyssAKKI-KTSPHERN 81
Cdd:TIGR03265   5 LSIDNIRKRFGAFTALKDISLSVKKGEFVCLLGPSGCGKTTLLRIIAGLERQTAGTIYQG-------GRDItRLPPQKRD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   82 IGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:TIGR03265  78 YGIVFQSYALFPNLTVADNIAYGLKNRGmGRAEVAERVAELLDLVGLPGSERKYPGQLSGGQQQRVALARALATSPGLLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:TIGR03265 158 LDEPLSALDARVREHLRTEIRQLQRRLGVTTIMVTHDQEEALSMADRIVVMNHGVIEQVGTPQEIYRHPATPFVADFVGE 237


                  ....
gi 446273968  241 ANWL 244
Cdd:TIGR03265 238 VNWL 241

ABC_arch_GlcV

NF040933

glucose ABC transporter ATP-binding protein GlcV;

1-248

6.46e-87

glucose ABC transporter ATP-binding protein GlcV;

Pssm-ID: 468866 [Multi-domain] Cd Length: 357 Bit Score: 265.32 E-value: 6.46e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGK----TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcMYSSAKKIKTS 76
Cdd:NF040933   1 VTVRVENVTKIFKKgkkeVVALDNVNLEIKSGEFFGILGPSGHGKTTFLRIIAGLEVPTDGEIYFDDK-LVASPGKIIVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  77 PHERNIGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:NF040933  80 PEDRNIGMVFQNWALYPNMTVFDNIAFPLKIKKvPKDEIEKKVKEVAEILGISEVLDRYPRELSGGQQQRVALARALVKN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVA 235
Cdd:NF040933 160 PQVLLLDEPFSNLDARIRDSARALVKKIQRELKITTIIVSHDPADIFSLADRAGVINNGKFQQVGKPEEIYDNPANIFVA 239

                        250
                 ....*....|...
gi 446273968 236 KFVGKANwLVEGK 248
Cdd:NF040933 240 RLIGDIN-LLEGK 251

tungstate_WtpC

NF040840

tungstate ABC transporter ATP-binding protein WtpC;

3-247

6.85e-74

tungstate ABC transporter ATP-binding protein WtpC;

Pssm-ID: 468779 [Multi-domain] Cd Length: 347 Bit Score: 231.50 E-value: 6.85e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFgKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHE-RN 81
Cdd:NF040840   2 IRIENLSKDW-KEFKLRDISLEVKEGEYFIILGPSGAGKTVLLELIAGIWPPDSGKIYLDG-------KDITNLPPEkRG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:NF040840  74 IAYVYQNYMLFPHKTVFENIAFGLKLRKvPKEEIERKVKEIMELLGISHLLHRKPRTLSGGEQQRVALARALIIEPKLLL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:NF040840 154 LDEPLSALDVQTRDELIREMKRWHREFGFTAIHVTHNFEEALSLADRVGIMLNGRLSQVGDVREVFRRPKNEFVARFVGF 233


                 ....*..
gi 446273968 241 ANwLVEG 247
Cdd:NF040840 234 EN-IIEG 239

ABC_tran

pfam00005

ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...

18-166

7.79e-45

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.

Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 150.11 E-value: 7.79e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIktspHERNIGMVFQDFALWPHMNV 97
Cdd:pfam00005   1 LKNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDERKS----LRKEIGYVFQDPQLFPRLTV 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968   98 FENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKR----YPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:pfam00005  77 RENLRLGLLLKGlSKREKDARAEEALEKLGLGDLADRpvgeRPGTLSGGQRQRVAIARALLTKPKLLLLDEPTA 150

ABC_ATP_DarD

NF038007

darobactin export ABC transporter ATP-binding protein;

14-214

1.10e-39

darobactin export ABC transporter ATP-binding protein;

Pssm-ID: 411600 [Multi-domain] Cd Length: 218 Bit Score: 139.08 E-value: 1.10e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIktSPHERNIGMVFQDFAL 91
Cdd:NF038007  17 KTKVLNHLNFSVEKGDFVSIMGPSGSGKSTLLNIIGMFDSLDSGSLTLAgkEVTNLSYSQKI--ILRRELIGYIFQSFNL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 WPHMNVFENVAFGL--RATKQTNQLrEKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:NF038007  95 IPHLSIFDNVALPLkyRGVAKKERI-ERVNQVLNLFGIDNRRNHKPMQLSGGQQQRVAIARAMVSNPALLLADEPTGNLD 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446273968 170 AILREEMrLELMDIVHSIGLTALYVTHDQtEAMSMSDQIIVMKQG 214
Cdd:NF038007 174 SKNARAV-LQQLKYINQKGTTIIMVTHSD-EASTYGNRIINMKDG 216

AztA

NF040873

zinc ABC transporter ATP-binding protein AztA;

12-209

1.11e-27

zinc ABC transporter ATP-binding protein AztA;

Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 106.55 E-value: 1.11e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmyssakkikTSPHERNIGMVFQDFAL 91
Cdd:NF040873   2 YGGRPVLHGVDLTIPAGSLTAVVGPNGSGKSTLLKVLAGVLRPTSGTV---------------RRAGGARVAYVPQRSEV 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 ---WPhMNVFENVAFGLRATKQ-----TNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:NF040873  67 pdsLP-LTVRDLVAMGRWARRGlwrrlTRDDRAAVDDALERVGLADLAGRQLGELSGGQRQRALLAQGLAQEADLLLLDE 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446273968 164 PLSALDAILREEMRlELMDIVHSIGLTALYVTHDQTEAMSMSDQII 209
Cdd:NF040873 146 PTTGLDAESRERII-ALLAEEHARGATVVVVTHDLELVRRADPCVL 190

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

26-225

3.26e-12

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 67.46 E-value: 3.26e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIY-FG---DtcmyssAKKIKTsphERNIGMVFQDFALWPHMNVFENV 101
Cdd:NF033858 290 RRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWlFGqpvD------AGDIAT---RRRVGYMSQAFSLYGELTVRQNL 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 102 A-----FGLRAtkqtNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEM 176
Cdd:NF033858 361 ElharlFHLPA----AEIAARVAEMLERFDLADVADALPDSLPLGIRQRLSLAVAVIHKPELLILDEPTSGVDPVARDMF 436

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446273968 177 -RLeLMDIVHSIGLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDI 225
Cdd:NF033858 437 wRL-LIELSREDGVTIFISTHFMNEAER-CDRISLMHAGRVLASDTPAAL 484

AAA

smart00382

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

27-215

4.71e-12

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 62.78 E-value: 4.71e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    27 QGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakkiktsphernigmvfqdfalwphmnvfenvafglr 106
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDG------------------------------------------ 38

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   107 atkqtnqlrEKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA-----ILREEMRLELM 181
Cdd:smart00382  39 ---------EDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLILDEITSLLDAeqealLLLLEELRLLL 109

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 446273968   182 DIVHSIGLTALYVTHDQTEAMSM-----SDQIIVMKQGE 215
Cdd:smart00382 110 LLKSEKNLTVILTTNDEKDLGPAllrrrFDRRIVLLLIL 148

40850658_otr

NF000106

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

3-228

5.92e-11

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

Pssm-ID: 411078 [Multi-domain] Cd Length: 351 Bit Score: 62.83 E-value: 5.92e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCG--KTTLLRMIAGleePDKGE--IYFGDTCMYSSAKKIKTSPH 78
Cdd:NF000106  14 VEVRGLVKHFGEVKAVDGVDLDVREGTVLGVLGP*GAA**RGALPAHV*G---PDAGRrpWRF*TWCANRRALRRTIG*H 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFAlwPHMNVFenvAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:NF000106  91 RPVR*GRRESFS--GRENLY---MIGR*LDLSRKDARARADELLERFSLTEAAGRAAAKYSGGMRRRLDLAASMIGRPAV 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 159 ILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:NF000106 166 LYLDEPTTGLDPRTRNEVWDEVRSMVRD-GATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDELKTK 234

GguA

NF040905

sugar ABC transporter ATP-binding protein;

7-214

1.56e-08

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 55.57 E-value: 1.56e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   7 GLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGL------EepdkGEIYF-GDTCMYssaKKIKTSpHE 79
Cdd:NF040905   6 GITKTFPGVKALDDVNLSVREGEIHALCGENGAGKSTLMKVLSGVyphgsyE----GEILFdGEVCRF---KDIRDS-EA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDFALWPHMNVFENVAFG-LRATK---QTNQLREKVEDAIKRVRLqgmeKRYPHELSG----GQQQRVAFARA 151
Cdd:NF040905  78 LGIVIIHQELALIPYLSIAENIFLGnERAKRgviDWNETNRRARELLAKVGL----DESPDTLVTdigvGKQQLVEIAKA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 152 IVTKPHFILFDEPLSAL---DAilreEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:NF040905 154 LSKDVKLLILDEPTAALneeDS----AALLDLLLELKAQGITSIIISHKLNEIRRVADSITVLRDG 215

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

3-225

1.46e-05

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 46.66 E-value: 1.46e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF--GDtcMYSSAKKIKTSPH-- 78
Cdd:NF033858   2 ARLEGVSHRYGKTVALDDVSLDIPAGCMVGLIGPDGVGKSSLLSLIAGARKIQQGRVEVlgGD--MADARHRRAVCPRia 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ------ERNigmvfqdfaLWPHMNVFENVAF-----GLRATkqtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVA 147
Cdd:NF033858  80 ympqglGKN---------LYPTLSVFENLDFfgrlfGQDAA----ERRRRIDELLRATGLAPFADRPAGKLSGGMKQKLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAILR-------EEMRLElmdivhSIGLTALYVTHDQTEAMSMsDQIIVMKQGEVLQKG 220
Cdd:NF033858 147 LCCALIHDPDLLILDEPTTGVDPLSRrqfweliDRIRAE------RPGMSVLVATAYMEEAERF-DWLVAMDAGRVLATG 219


                 ....*
gi 446273968 221 TPEDI 225
Cdd:NF033858 220 TPAEL 224

Name

Accession

Description

Interval

E-value

PotA

COG3842

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ...

2-317

1.73e-148

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 421.81 E-value: 1.73e-148

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSsakkikTSPHERN 81
Cdd:COG3842    5 ALELENVSKRYGDVTALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFETPDSGRILLDGRDVTG------LPPEKRN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG3842   79 VGMVFQDYALFPHLTVAENVAFGLRMRGVPkAEIRARVAELLELVGLEGLADRYPHQLSGGQQQRVALARALAPEPRVLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:COG3842  159 LDEPLSALDAKLREEMREELRRLQRELGITFIYVTHDQEEALALADRIAVMNDGRIEQVGTPEEIYERPATRFVADFIGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 241 ANWL-------------VEGKQ-----------------MIRPEHVSWTKNEVCEMYTGEIQHVTYVGERYEMKVNMGAL 290
Cdd:COG3842  239 ANLLpgtvlgdegggvrTGGRTlevpadaglaaggpvtvAIRPEDIRLSPEGPENGLPGTVEDVVFLGSHVRYRVRLGDG 318

                        330       340       350
                 ....*....|....*....|....*....|.
gi 446273968 291 GIWTAY----HNSKLSIGKPVSLYVPKKYIH 317
Cdd:COG3842  319 QELVVRvpnrAALPLEPGDRVGLSWDPEDVV 349

MalK

COG3839

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; ...

2-317

2.31e-133

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism];

Pssm-ID: 443050 [Multi-domain] Cd Length: 352 Bit Score: 383.27 E-value: 2.31e-133

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERN 81
Cdd:COG3839    3 SLELENVSKSYGGVEALKDIDLDIEDGEFLVLLGPSGCGKSTLLRMIAGLEDPTSGEILIGGRDV------TDLPPKDRN 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG3839   77 IAMVFQSYALYPHMTVYENIAFPLKLRKVPkAEIDRRVREAAELLGLEDLLDRKPKQLSGGQRQRVALGRALVREPKVFL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG- 239
Cdd:COG3839  157 LDEPLSNLDAKLRVEMRAEIKRLHRRLGTTTIYVTHDQVEAMTLADRIAVMNDGRIQQVGTPEELYDRPANLFVAGFIGs 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 240 -----------KANWLVEGKQM-----------------IRPEHVSWTKNEVCEMyTGEIQHVTYVGERYEMKVNMGAlG 291
Cdd:COG3839  237 ppmnllpgtveGGGVRLGGVRLplpaalaaaaggevtlgIRPEHLRLADEGDGGL-EATVEVVEPLGSETLVHVRLGG-Q 314

                        330       340
                 ....*....|....*....|....*...
gi 446273968 292 IWTAY--HNSKLSIGKPVSLYVPKKYIH 317
Cdd:COG3839  315 ELVARvpGDTRLRPGDTVRLAFDPERLH 342

CysA

COG1118

ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and ...

1-244

6.40e-121

ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440735 [Multi-domain] Cd Length: 348 Bit Score: 351.37 E-value: 6.40e-121

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYssakkIKTSPHER 80
Cdd:COG1118    1 MSIEVRNISKRFGSFTLLDDVSLEIASGELVALLGPSGSGKTTLLRIIAGLETPDSGRIVLNGRDLF-----TNLPPRER 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFENVAFGLRATKQTN-QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:COG1118   76 RVGFVFQHYALFPHMTVAENIAFGLRVRPPSKaEIRARVEELLELVQLEGLADRYPSQLSGGQRQRVALARALAVEPEVL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 160 LFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:COG1118  156 LLDEPFGALDAKVRKELRRWLRRLHDELGGTTVFVTHDQEEALELADRVVVMNQGRIEQVGTPDEVYDRPATPFVARFLG 235


                 ....*
gi 446273968 240 KANWL 244
Cdd:COG1118  236 CVNVL 240

ABC_PotA_N

cd03300

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ...

3-239

8.50e-118

Pssm-ID: 213267 [Multi-domain] Cd Length: 232 Bit Score: 339.21 E-value: 8.50e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNI 82
Cdd:cd03300    1 IELENVSKFYGGFVALDGVSLDIKEGEFFTLLGPSGCGKTTLLRLIAGFETPTSGEILLDGKDI------TNLPPHKRPV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRaTKQTNQ--LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:cd03300   75 NTVFQNYALFPHLTVFENIAFGLR-LKKLPKaeIKERVAEALDLVQLEGYANRKPSQLSGGQQQRVAIARALVNEPKVLL 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:cd03300  154 LDEPLGALDLKLRKDMQLELKRLQKELGITFVFVTHDQEEALTMSDRIAVMNKGKIQQIGTPEEIYEEPANRFVADFIG 232

ABC_Carb_Solutes_like

cd03259

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ...

3-220

4.16e-112

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 324.09 E-value: 4.16e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNI 82
Cdd:cd03259    1 LELKGLSKTYGSVRALDDLSLTVEPGEFLALLGPSGCGKTTLLRLIAGLERPDSGEILIDGRDV------TGVPPERRNI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTN-QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:cd03259   75 GMVFQDYALFPHLTVAENIAFGLKLRGVPKaEIRARVRELLELVGLEGLLNRYPHELSGGQQQRVALARALAREPSLLLL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03259  155 DEPLSALDAKLREELREELKELQRELGITTIYVTHDQEEALALADRIAVMNEGRIVQVG 213

potA

PRK09452

spermidine/putrescine ABC transporter ATP-binding protein PotA;

3-242

6.55e-105

spermidine/putrescine ABC transporter ATP-binding protein PotA;

Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 311.88 E-value: 6.55e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNI 82
Cdd:PRK09452  15 VELRGISKSFDGKEVISNLDLTINNGEFLTLLGPSGCGKTTVLRLIAGFETPDSGRIMLDGQDI------THVPAENRHV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTNQ-LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:PRK09452  89 NTVFQSYALFPHMTVFENVAFGLRMQKTPAAeITPRVMEALRMVQLEEFAQRKPHQLSGGQQQRVAIARAVVNKPKVLLL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGKA 241
Cdd:PRK09452 169 DESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVARFIGEI 248


                 .
gi 446273968 242 N 242
Cdd:PRK09452 249 N 249

ABC_CysA_sulfate_importer

cd03296

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ...

1-239

1.52e-99

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213263 [Multi-domain] Cd Length: 239 Bit Score: 293.09 E-value: 1.52e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssaKKIKTSPHER 80
Cdd:cd03296    1 MSIEVRNVSKRFGDFVALDDVSLDIPSGELVALLGPSGSGKTTLLRLIAGLERPDSGTILFGGE------DATDVPVQER 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFENVAFGLRATKQT-----NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:cd03296   75 NVGFVFQHYALFRHMTVFDNVAFGLRVKPRSerppeAEIRAKVHELLKLVQLDWLADRYPAQLSGGQRQRVALARALAVE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVA 235
Cdd:cd03296  155 PKVLLLDEPFGALDAKVRKELRRWLRRLHDELHVTTVFVTHDQEEALEVADRVVVMNKGRIEQVGTPDEVYDHPASPFVY 234


                 ....
gi 446273968 236 KFVG 239
Cdd:cd03296  235 SFLG 238

PhnT2

TIGR03265

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ...

3-244

4.07e-97

Pssm-ID: 274496 [Multi-domain] Cd Length: 353 Bit Score: 291.17 E-value: 4.07e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGdtcmyssAKKI-KTSPHERN 81
Cdd:TIGR03265   5 LSIDNIRKRFGAFTALKDISLSVKKGEFVCLLGPSGCGKTTLLRIIAGLERQTAGTIYQG-------GRDItRLPPQKRD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   82 IGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:TIGR03265  78 YGIVFQSYALFPNLTVADNIAYGLKNRGmGRAEVAERVAELLDLVGLPGSERKYPGQLSGGQQQRVALARALATSPGLLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:TIGR03265 158 LDEPLSALDARVREHLRTEIRQLQRRLGVTTIMVTHDQEEALSMADRIVVMNHGVIEQVGTPQEIYRHPATPFVADFVGE 237


                  ....
gi 446273968  241 ANWL 244
Cdd:TIGR03265 238 VNWL 241

ABC_MalK_N

cd03301

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) ...

3-220

4.41e-96

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two transmembrane-spanning domains (TMDs) or subunits and two nucleotide binding domains (NBDs) or subunits that couple transport to the hydrolysis of ATP. In the maltose transport system, the periplasmic maltose binding protein (MBP) stimulates the ATPase activity of the membrane-associated transporter, which consists of two transmembrane subunits, MalF and MalG, and two copies of the ATP binding subunit, MalK, and becomes tightly bound to the transporter in the catalytic transition state, ensuring that maltose is passed to the transporter as ATP is hydrolyzed.

Pssm-ID: 213268 [Multi-domain] Cd Length: 213 Bit Score: 283.38 E-value: 4.41e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNI 82
Cdd:cd03301    1 VELENVTKRFGNVTALDDLNLDIADGEFVVLLGPSGCGKTTTLRMIAGLEEPTSGRIYIGGRDV------TDLPPKDRDI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTNQ-LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:cd03301   75 AMVFQNYALYPHMTVYDNIAFGLKLRKVPKDeIDERVREVAELLQIEHLLDRKPKQLSGGQRQRVALGRAIVREPKVFLM 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03301  155 DEPLSNLDAKLRVQMRAELKRLQQRLGTTTIYVTHDQVEAMTMADRIAVMNDGQIQQIG 213

potA

TIGR01187

spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine ...

33-306

8.29e-96

spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine/putrescine ABC transporter, ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Polyamines like spermidine and putrescine play vital role in cell proliferation, differentiation, and ion homeostasis. The concentration of polyamines within the cell are regulated by biosynthesis, degradation and transport (uptake and efflux included). [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 162242 [Multi-domain] Cd Length: 325 Bit Score: 286.70 E-value: 8.29e-96

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNIGMVFQDFALWPHMNVFENVAFGLRATKQTN 112
Cdd:TIGR01187   1 LLGPSGCGKTTLLRLLAGFEQPDSGSIMLDGEDV------TNVPPHLRHINMVFQSYALFPHMTVEENVAFGLKMRKVPR 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  113 -QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTA 191
Cdd:TIGR01187  75 aEIKPRVLEALRLVQLEEFADRKPHQLSGGQQQRVALARALVFKPKILLLDEPLSALDKKLRDQMQLELKTIQEQLGITF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  192 LYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGKANWL--------------------------- 244
Cdd:TIGR01187 155 VFVTHDQEEAMTMSDRIAIMRKGKIAQIGTPEEIYEEPANLFVARFIGEINVFeatvierkseqvvlagvegrrcdiytd 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446273968  245 --VEGKQ----MIRPEHVSW---TKNEVCEMYTGEIQHVTYVGE--RYEMKVNMGALGIWTAYHNSKLSIGKP 306
Cdd:TIGR01187 235 vpVEKDQplhvVLRPEKIVIeeeDEANSSNAIIGHVIDITYLGMtlEVHVRLETGQKVLVSEFFNEDDPHMSP 307

fbpC

PRK11432

ferric ABC transporter ATP-binding protein;

10-286

1.30e-95

ferric ABC transporter ATP-binding protein;

Pssm-ID: 183133 [Multi-domain] Cd Length: 351 Bit Score: 287.39 E-value: 1.30e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  10 KNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmySSAKKIKTSPHERNIGMVFQDF 89
Cdd:PRK11432  14 KRFGSNTVIDNLNLTIKQGTMVTLLGPSGCGKTTVLRLVAGLEKPTEGQIFI------DGEDVTHRSIQQRDICMVFQSY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALWPHMNVFENVAFGLRATKQTN-QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSAL 168
Cdd:PRK11432  88 ALFPHMSLGENVGYGLKMLGVPKeERKQRVKEALELVDLAGFEDRYVDQISGGQQQRVALARALILKPKVLLFDEPLSNL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 169 DAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGKANWL---- 244
Cdd:PRK11432 168 DANLRRSMREKIRELQQQFNITSLYVTHDQSEAFAVSDTVIVMNKGKIMQIGSPQELYRQPASRFMASFMGDANIFpatl 247

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 245 ------VEGKQMIRPEHVSWTKNE-----------VCEMYTGE------IQHVTYVGERYEMKVN 286
Cdd:PRK11432 248 sgdyvdIYGYRLPRPAAFAFNLPDgectvgvrpeaITLSEQGEesqrctIKHVAYMGPQYEVTVD 312

ugpC

PRK11650

sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;

3-239

2.40e-94

sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;

Pssm-ID: 236947 [Multi-domain] Cd Length: 356 Bit Score: 284.04 E-value: 2.40e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF-GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT-SPHER 80
Cdd:PRK11650   4 LKLQAVRKSYdGKTQVIKGIDLDVADGEFIVLVGPSGCGKSTLLRMVAGLERITSGEIWIGG-------RVVNElEPADR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFENVAFGL--RATKQTnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:PRK11650  77 DIAMVFQNYALYPHMSVRENMAYGLkiRGMPKA-EIEERVAEAARILELEPLLDRKPRELSGGQRQRVAMGRAIVREPAV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 159 ILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:PRK11650 156 FLFDEPLSNLDAKLRVQMRLEIQRLHRRLKTTSLYVTHDQVEAMTLADRVVVMNGGVAEQIGTPVEVYEKPASTFVASFI 235


                 .
gi 446273968 239 G 239
Cdd:PRK11650 236 G 236

TauB

COG1116

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion ...

3-214

4.91e-92

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440733 [Multi-domain] Cd Length: 260 Bit Score: 274.66 E-value: 4.91e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssakKIKTSPH 78
Cdd:COG1116    8 LELRGVSKRFptggGGVTALDDVSLTVAAGEFVALVGPSGCGKSTLLRLIAGLEKPTSGEVLVDG--------KPVTGPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERnIGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:COG1116   80 PD-RGVVFQEPALLPWLTVLDNVALGLELRGVPkAERRERARELLELVGLAGFEDAYPHQLSGGMRQRVAIARALANDPE 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 158 FILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:COG1116  159 VLLMDEPFGALDALTRERLQDELLRLWQETGKTVLFVTHDVDEAVFLADRVVVLSAR 215

ABC_NrtD_SsuB_transporters

cd03293

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ...

3-211

1.54e-88

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 264.33 E-value: 1.54e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFG----KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssakKIKTSPH 78
Cdd:cd03293    1 LEVRNVSKTYGggggAVTALEDISLSVEEGEFVALVGPSGCGKSTLLRIIAGLERPTSGEVLVDG--------EPVTGPG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 eRNIGMVFQDFALWPHMNVFENVAFGLRAT-KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:cd03293   73 -PDRGYVFQQDALLPWLTVLDNVALGLELQgVPKAEARERAEELLELVGLSGFENAYPHQLSGGMRQRVALARALAVDPD 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446273968 158 FILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVM 211
Cdd:cd03293  152 VLLLDEPFSALDALTREQLQEELLDIWRETGKTVLLVTHDIDEAVFLADRVVVL 205

ABC_arch_GlcV

NF040933

glucose ABC transporter ATP-binding protein GlcV;

1-248

6.46e-87

glucose ABC transporter ATP-binding protein GlcV;

Pssm-ID: 468866 [Multi-domain] Cd Length: 357 Bit Score: 265.32 E-value: 6.46e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGK----TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcMYSSAKKIKTS 76
Cdd:NF040933   1 VTVRVENVTKIFKKgkkeVVALDNVNLEIKSGEFFGILGPSGHGKTTFLRIIAGLEVPTDGEIYFDDK-LVASPGKIIVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  77 PHERNIGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:NF040933  80 PEDRNIGMVFQNWALYPNMTVFDNIAFPLKIKKvPKDEIEKKVKEVAEILGISEVLDRYPRELSGGQQQRVALARALVKN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVA 235
Cdd:NF040933 160 PQVLLLDEPFSNLDARIRDSARALVKKIQRELKITTIIVSHDPADIFSLADRAGVINNGKFQQVGKPEEIYDNPANIFVA 239

                        250
                 ....*....|...
gi 446273968 236 KFVGKANwLVEGK 248
Cdd:NF040933 240 RLIGDIN-LLEGK 251

3a0106s01

TIGR00968

sulfate ABC transporter, ATP-binding protein; [Transport and binding proteins, Anions]

3-244

7.94e-86

sulfate ABC transporter, ATP-binding protein; [Transport and binding proteins, Anions]

Pssm-ID: 130041 [Multi-domain] Cd Length: 237 Bit Score: 258.19 E-value: 7.94e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssaKKIKTSPHERNI 82
Cdd:TIGR00968   1 IEIANISKRFGSFQALDDVNLEVPTGSLVALLGPSGSGKSTLLRIIAGLEQPDSGRIRLNGQ------DATRVHARDRKI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   83 GMVFQDFALWPHMNVFENVAFGLRATKQTNQL-REKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:TIGR00968  75 GFVFQHYALFKHLTVRDNIAFGLEIRKHPKAKiKARVEELLELVQLEGLGDRYPNQLSGGQRQRVALARALAVEPQVLLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGKA 241
Cdd:TIGR00968 155 DEPFGALDAKVRKELRSWLRKLHDEVHVTTVFVTHDQEEAMEVADRIVVMSNGKIEQIGSPDEVYDHPANPFVMSFLGEV 234


                  ...
gi 446273968  242 NWL 244
Cdd:TIGR00968 235 NVL 237

PhnT

TIGR03258

2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; This ATP-binding ...

3-244

3.74e-81

2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; This ATP-binding component of an ABC transport system is found in Salmonella and Burkholderia lineages in the vicinity of enzymes for the breakdown of 2-aminoethylphosphonate.

Pssm-ID: 132302 [Multi-domain] Cd Length: 362 Bit Score: 250.68 E-value: 3.74e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD--KGEIYFGDTCMyssakkIKTSPHER 80
Cdd:TIGR03258   6 IRIDHLRVAYGANTVLDDLSLEIEAGELLALIGKSGCGKTTLLRAIAGFVKAAglTGRIAIADRDL------THAPPHKR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   81 NIGMVFQDFALWPHMNVFENVAFGLRATKQTNQL-REKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:TIGR03258  80 GLALLFQNYALFPHLKVEDNVAFGLRAQKMPKADiAERVADALKLVGLGDAAAHLPAQLSGGMQQRIAIARAIAIEPDVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  160 LFDEPLSALDAILREEMRLELMDIVHSI-GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:TIGR03258 160 LLDEPLSALDANIRANMREEIAALHEELpELTILCVTHDQDDALTLADKAGIMKDGRLAAHGEPQALYDAPADGFAAEFL 239


                  ....*.
gi 446273968  239 GKANWL 244
Cdd:TIGR03258 240 GAANIL 245

PRK11000

maltose/maltodextrin ABC transporter ATP-binding protein MalK;

2-290

4.38e-81

maltose/maltodextrin ABC transporter ATP-binding protein MalK;

Pssm-ID: 182893 [Multi-domain] Cd Length: 369 Bit Score: 250.72 E-value: 4.38e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSsakkikTSPHERN 81
Cdd:PRK11000   3 SVTLRNVTKAYGDVVISKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLEDITSGDLFIGEKRMND------VPPAERG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:PRK11000  77 VGMVFQSYALYPHLSVAENMSFGLKlAGAKKEEINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG- 239
Cdd:PRK11000 157 LDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPANRFVAGFIGs 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 240 -KAN------------------------WL-VEGKQM---------IRPEH-VSWTKNEVCemYTGEIQHVTYVGERYEM 283
Cdd:PRK11000 237 pKMNflpvkvtataieqvqvelpnrqqvWLpVEGRGVqvganmslgIRPEHlLPSDIADVT--LEGEVQVVEQLGNETQI 314


                 ....*..
gi 446273968 284 KVNMGAL 290
Cdd:PRK11000 315 HIQIPAI 321

OpuBA

COG1125

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and ...

3-240

7.26e-81

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440742 [Multi-domain] Cd Length: 306 Bit Score: 248.08 E-value: 7.26e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF-GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT-SPHE- 79
Cdd:COG1125    2 IEFENVTKRYpDGTVAVDDLSLTIPAGEFTVLVGPSGCGKTTTLRMINRLIEPTSGRILIDG-------EDIRDlDPVEl 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 -RNIGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRL--QGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:COG1125   75 rRRIGYVIQQIGLFPHMTVAENIATVPRLLGWDkERIRARVDELLELVGLdpEEYRDRYPHELSGGQQQRVGVARALAAD 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVA 235
Cdd:COG1125  155 PPILLMDEPFGALDPITREQLQDELLRLQRELGKTIVFVTHDIDEALKLGDRIAVMREGRIVQYDTPEEILANPANDFVA 234


                 ....*
gi 446273968 236 KFVGK 240
Cdd:COG1125  235 DFVGA 239

ABC_ModC_molybdenum_transporter

cd03297

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type ...

28-220

2.01e-79

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213264 [Multi-domain] Cd Length: 214 Bit Score: 241.05 E-value: 2.01e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFGLRA 107
Cdd:cd03297   23 EEVTGIFGASGAGKSTLLRCIAGLEKPDGGTIVLNGTVLFDSRKKINLPPQQRKIGLVFQQYALFPHLNVRENLAFGLKR 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 108 tKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSI 187
Cdd:cd03297  103 -KRNREDRISVDELLDLLGLDHLLNRYPAQLSGGEKQRVALARALAAQPELLLLDEPFSALDRALRLQLLPELKQIKKNL 181

                        170       180       190
                 ....*....|....*....|....*....|...
gi 446273968 188 GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03297  182 NIPVIFVTHDLSEAEYLADRIVVMEDGRLQYIG 214

GlnQ

COG1126

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and ...

3-240

3.90e-79

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440743 [Multi-domain] Cd Length: 239 Bit Score: 241.05 E-value: 3.90e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTspHERNI 82
Cdd:COG1126    2 IEIENLHKSFGDLEVLKGISLDVEKGEVVVIIGPSGSGKSTLLRCINLLEEPDSGTITVDGEDLTDSKKDINK--LRRKV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTN--QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG1126   80 GMVFQQFNLFPHLTVLENVTLAPIKVKKMSkaEAEERAMELLERVGLADKADAYPAQLSGGQQQRVAIARALAMEPKVML 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMrLELM-DIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:COG1126  160 FDEPTSALDPELVGEV-LDVMrDLAKE-GMTMVVVTHEMGFAREVADRVVFMDGGRIVEEGPPEEFFENPQHERTRAFLS 237


                 .
gi 446273968 240 K 240
Cdd:COG1126  238 K 238

PRK10851

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;

1-255

1.17e-77

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;

Pssm-ID: 182778 [Multi-domain] Cd Length: 353 Bit Score: 241.53 E-value: 1.17e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYssakkiKTSPHER 80
Cdd:PRK10851   1 MSIEIANIKKSFGRTQVLNDISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQTSGHIRFHGTDVS------RLHARDR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFENVAFGL-----RATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:PRK10851  75 KVGFVFQHYALFRHMTVFDNIAFGLtvlprRERPNAAAIKAKVTQLLEMVQLAHLADRYPAQLSGGQKQRVALARALAVE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVA 235
Cdd:PRK10851 155 PQILLLDEPFGALDAQVRKELRRWLRQLHEELKFTSVFVTHDQEEAMEVADRVVVMSQGNIEQAGTPDQVWREPATRFVL 234

                        250       260
                 ....*....|....*....|....
gi 446273968 236 KFVGKANWL---VEGKQM-IRPEH 255
Cdd:PRK10851 235 EFMGEVNRLqgtIRGGQFhVGAHR 258

ABC_ModC_like

cd03299

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely ...

3-242

1.28e-77

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213266 [Multi-domain] Cd Length: 235 Bit Score: 237.23 E-value: 1.28e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQaLKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKT-SPHERN 81
Cdd:cd03299    1 LKVENLSKDWKEFK-LKNVSLEVERGDYFVILGPTGSGKSVLLETIAGFIKPDSGKILL-------NGKDITNlPPEKRD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRatkqtNQLREKVEDAiKRVR----LQGME---KRYPHELSGGQQQRVAFARAIVT 154
Cdd:cd03299   73 ISYVPQNYALFPHMTVYKNIAYGLK-----KRKVDKKEIE-RKVLeiaeMLGIDhllNRKPETLSGGEQQRVAIARALVV 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 155 KPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFV 234
Cdd:cd03299  147 NPKILLLDEPFSALDVRTKEKLREELKKIRKEFGVTVLHVTHDFEEAWALADKVAIMLNGKLIQVGKPEEVFKKPKNEFV 226


                 ....*...
gi 446273968 235 AKFVGKAN 242
Cdd:cd03299  227 AEFLGFNN 234

ABC_Class3

cd03229

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ...

3-215

3.69e-77

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 234.00 E-value: 3.69e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtsPHERNI 82
Cdd:cd03229    1 LELKNVSKRYGQKTVLNDVSLNIEAGEIVALLGPSGSGKSTLLRCIAGLEEPDSGSILIDGEDLTDLEDELP--PLRRRI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGlratkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:cd03229   79 GMVFQDFALFPHLTVLENIALG---------------------------------LSGGQQQRVALARALAMDPDVLLLD 125

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446273968 163 EPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:cd03229  126 EPTSALDPITRREVRALLKSLQAQLGITVVLVTHDLDEAARLADRVVVLRDGK 178

MlaF

COG1127

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ...

3-238

5.70e-77

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 235.64 E-value: 5.70e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYS-SAKKIKtsPHERN 81
Cdd:COG1127    6 IEVRNLTKSFGDRVVLDGVSLDVPRGEILAIIGGSGSGKSVLLKLIIGLLRPDSGEILVDGQDITGlSEKELY--ELRRR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRA-TKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:COG1127   84 IGMLFQGGALFDSLTVFENVAFPLREhTDLSeAEIRELVLEKLELVGLPGAADKMPSELSGGMRKRVALARALALDPEIL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 160 LFDEPLSALDAI-LREEMRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYvKPSHEFVAKFV 238
Cdd:COG1127  164 LYDEPTAGLDPItSAVIDEL-IRELRDELGLTSVVVTHDLDSAFAIADRVAVLADGKIIAEGTPEELL-ASDDPWVRQFL 241

ABC_Pro_Gly_Betaine

cd03294

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This ...

8-238

1.00e-76

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213261 [Multi-domain] Cd Length: 269 Bit Score: 236.00 E-value: 1.00e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   8 LEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQ 87
Cdd:cd03294   30 ILKKTGQTVGVNDVSLDVREGEIFVIMGLSGSGKSTLLRCINRLIEPTSGKVLIDGQDIAAMSRKELRELRRKKISMVFQ 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  88 DFALWPHMNVFENVAFGLRATKQTNQLR-EKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:cd03294  110 SFALLPHRTVLENVAFGLEVQGVPRAEReERAAEALELVGLEGWEHKYPDELSGGMQQRVGLARALAVDPDILLMDEAFS 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 167 ALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:cd03294  190 ALDPLIRREMQDELLRLQAELQKTIVFITHDLDEALRLGDRIAIMKDGRLVQVGTPEEILTNPANDYVREFF 261

potG

PRK11607

putrescine ABC transporter ATP-binding subunit PotG;

3-247

3.11e-76

putrescine ABC transporter ATP-binding subunit PotG;

Pssm-ID: 183226 [Multi-domain] Cd Length: 377 Bit Score: 238.58 E-value: 3.11e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcMYSSAKKIKTSPHERNI 82
Cdd:PRK11607  20 LEIRNLTKSFDGQHAVDDVSLTIYKGEIFALLGASGCGKSTLLRMLAGFEQPTAGQI------MLDGVDLSHVPPYQRPI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:PRK11607  94 NMMFQSYALFPHMTVEQNIAFGLKQDKlPKAEIASRVNEMLGLVHMQEFAKRKPHQLSGGQRQRVALARSLAKRPKLLLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGKA 241
Cdd:PRK11607 174 DEPMGALDKKLRDRMQLEVVDILERVGVTCVMVTHDQEEAMTMAGRIAIMNRGKFVQIGEPEEIYEHPTTRYSAEFIGSV 253


                 ....*.
gi 446273968 242 NwLVEG 247
Cdd:PRK11607 254 N-VFEG 258

tungstate_WtpC

NF040840

tungstate ABC transporter ATP-binding protein WtpC;

3-247

6.85e-74

tungstate ABC transporter ATP-binding protein WtpC;

Pssm-ID: 468779 [Multi-domain] Cd Length: 347 Bit Score: 231.50 E-value: 6.85e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFgKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHE-RN 81
Cdd:NF040840   2 IRIENLSKDW-KEFKLRDISLEVKEGEYFIILGPSGAGKTVLLELIAGIWPPDSGKIYLDG-------KDITNLPPEkRG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:NF040840  74 IAYVYQNYMLFPHKTVFENIAFGLKLRKvPKEEIERKVKEIMELLGISHLLHRKPRTLSGGEQQRVALARALIIEPKLLL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:NF040840 154 LDEPLSALDVQTRDELIREMKRWHREFGFTAIHVTHNFEEALSLADRVGIMLNGRLSQVGDVREVFRRPKNEFVARFVGF 233


                 ....*..
gi 446273968 241 ANwLVEG 247
Cdd:NF040840 234 EN-IIEG 239

ABC_OpuCA_Osmoprotection

cd03295

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ...

3-240

1.46e-72

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213262 [Multi-domain] Cd Length: 242 Bit Score: 224.49 E-value: 1.46e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQ-ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIK-TSPHE- 79
Cdd:cd03295    1 IEFENVTKRYGGGKkAVNNLNLEIAKGEFLVLIGPSGSGKTTTMKMINRLIEPTSGEIFIDG-------EDIReQDPVEl 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 -RNIGMVFQDFALWPHMNVFENVAFGLRATK-QTNQLREKVEDAIKRVRL--QGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:cd03295   74 rRKIGYVIQQIGLFPHMTVEENIALVPKLLKwPKEKIRERADELLALVGLdpAEFADRYPHELSGGQQQRVGVARALAAD 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVA 235
Cdd:cd03295  154 PPLLLMDEPFGALDPITRDQLQEEFKRLQQELGKTIVFVTHDIDEAFRLADRIAIMKNGEIVQVGTPDEILRSPANDFVA 233


                 ....*
gi 446273968 236 KFVGK 240
Cdd:cd03295  234 EFVGA 238

ABC_MJ0796_LolCDE_FtsE

cd03255

ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...

3-216

1.08e-71

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.

Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 221.59 E-value: 1.08e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFG----KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPH 78
Cdd:cd03255    1 IELKNLSKTYGgggeKVQALKGVSLSIEKGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVRVDGTDISKLSEKELAAFR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:cd03255   81 RRHIGFVFQSFNLLPDLTALENVELPLLlAGVPKKERRERAEELLERVGLGDRLNHYPSELSGGQQQRVAIARALANDPK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 158 FILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDQTEAmSMSDQIIVMKQGEV 216
Cdd:cd03255  161 IILADEPTGNLDSETGKEvMEL-LRELNKEAGTTIVVVTHDPELA-EYADRIIELRDGKI 218

proV

TIGR01186

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine ...

10-240

1.11e-71

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Functionally, this transport system is involved in osmoregulation. Under conditions of stress, the organism recruits these transport system to accumulate glycine betaine and other solutes which offer osmo-protection. It has been demonstrated that glycine betaine uptake is accompanied by symport with sodium ions. The locus has been named variously as proU or opuA. A gene library from L.lactis functionally complements an E.coli proU mutant. The comlementing locus is similar to a opuA locus in B.sutlis. This clarifies the differences in nomenclature. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 130254 [Multi-domain] Cd Length: 363 Bit Score: 226.27 E-value: 1.11e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   10 KNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKtSPHERNIGMVFQD 88
Cdd:TIGR01186   1 KKTGGKKGVNDADLAIAKGEIFVIMGLSGSGKSTTVRMLNRLIEPTAGQIFIdGENIMKQSPVELR-EVRRKKIGMVFQQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   89 FALWPHMNVFENVAFGLRATKQTNQLR-EKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:TIGR01186  80 FALFPHMTILQNTSLGPELLGWPEQERkEKALELLKLVGLEEYEHRYPDELSGGMQQRVGLARALAAEPDILLMDEAFSA 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446273968  168 LDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVGK 240
Cdd:TIGR01186 160 LDPLIRDSMQDELKKLQATLQKTIVFITHDLDEAIRIGDRIVIMKAGEIVQVGTPDEILRNPANEYVEEFIGK 232

ABC_Org_Solvent_Resistant

cd03261

ATP-binding cassette transport system involved in resistance to organic solvents; ABC ...

3-237

3.33e-71

ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 220.84 E-value: 3.33e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPHERNI 82
Cdd:cd03261    1 IELRGLTKSFGGRTVLKGVDLDVRRGEILAIIGPSGSGKSTLLRLIVGLLRPDSGEVLIDGEDI-SGLSEAELYRLRRRM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQ--TNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:cd03261   80 GMLFQSGALFDSLTVFENVAFPLREHTRlsEEEIREIVLEKLEAVGLRGAEDLYPAELSGGMKKRVALARALALDPELLL 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIyVKPSHEFVAKF 237
Cdd:cd03261  160 YDEPTAGLDPIASGVIDDLIRSLKKELGLTSIMVTHDLDTAFAIADRIAVLYDGKIVAEGTPEEL-RASDDPLVRQF 235

ModC

COG4148

ABC-type molybdate transport system, ATPase component ModC [Inorganic ion transport and ...

31-225

5.03e-70

ABC-type molybdate transport system, ATPase component ModC [Inorganic ion transport and metabolism]; ABC-type molybdate transport system, ATPase component ModC is part of the Pathway/BioSystem: Molybdopterin biosynthesis

Pssm-ID: 443319 [Multi-domain] Cd Length: 358 Bit Score: 221.90 E-value: 5.03e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  31 TTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFGLRATKQ 110
Cdd:COG4148   28 TALFGPSGSGKTTLLRAIAGLERPDSGRIRLGGEVLQDSARGIFLPPHRRRIGYVFQEARLFPHLSVRGNLLYGRKRAPR 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 111 TNQlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLT 190
Cdd:COG4148  108 AER-RISFDEVVELLGIGHLLDRRPATLSGGERQRVAIGRALLSSPRLLLMDEPLAALDLARKAEILPYLERLRDELDIP 186

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446273968 191 ALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4148  187 ILYVSHSLDEVARLADHVVLLEQGRVVASGPLAEV 221

GsiA

COG1123

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...

3-232

2.40e-69

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 224.78 E-value: 2.40e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF-----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSP 77
Cdd:COG1123  261 LEVRNLSKRYpvrgkGGVRAVDDVSLTLRRGETLGLVGESGSGKSTLARLLLGLLRPTSGSILFDGKDL-TKLSRRSLRE 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HERNIGMVFQD-FA-LWPHMNVFENVAFGLRATKQTN--QLREKVEDAIKRVRLQ-GMEKRYPHELSGGQQQRVAFARAI 152
Cdd:COG1123  340 LRRRVQMVFQDpYSsLNPRMTVGDIIAEPLRLHGLLSraERRERVAELLERVGLPpDLADRYPHELSGGQRQRVAIARAL 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 153 VTKPHFILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSH 231
Cdd:COG1123  420 ALEPKLLILDEPTSALDVSVQAQiLNL-LRDLQRELGLTYLFISHDLAVVRYIADRVAVMYDGRIVEDGPTEEVFANPQH 498


                 .
gi 446273968 232 E 232
Cdd:COG1123  499 P 499

LolD

COG1136

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];

3-216

2.87e-69

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440751 [Multi-domain] Cd Length: 227 Bit Score: 215.68 E-value: 2.87e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFG----KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPH 78
Cdd:COG1136    5 LELRNLTKSYGtgegEVTALRGVSLSIEAGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVLIDGQDISSLSERELARLR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:COG1136   85 RRHIGFVFQFFNLLPELTALENVALPLLLAGVSrKERRERARELLERVGLGDRLDHRPSQLSGGQQQRVAIARALVNRPK 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 158 FILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDQtEAMSMSDQIIVMKQGEV 216
Cdd:COG1136  165 LILADEPTGNLDSKTGEEvLEL-LRELNRELGTTIVMVTHDP-ELAARADRVIRLRDGRI 222

ABC_HisP_GlnQ

cd03262

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ...

3-216

2.97e-67

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein.

Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 210.08 E-value: 2.97e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSphERNI 82
Cdd:cd03262    1 IEIKNLHKSFGDFHVLKGIDLTVKKGEVVVIIGPSGSGKSTLLRCINLLEEPDSGTIIIDGLKLTDDKKNINEL--RQKV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTN--QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:cd03262   79 GMVFQQFNLFPHLTVLENITLAPIKVKGMSkaEAEERALELLEKVGLADKADAYPAQLSGGQQQRVAIARALAMNPKVML 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 161 FDEPLSALDAILREEMrLELM-DIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03262  159 FDEPTSALDPELVGEV-LDVMkDLAEE-GMTMVVVTHEMGFAREVADRVIFMDDGRI 213

ThiQ

COG3840

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];

26-239

1.68e-66

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];

Pssm-ID: 443051 [Multi-domain] Cd Length: 232 Bit Score: 208.46 E-value: 1.68e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERNIGMVFQDFALWPHMNVFENVAFGL 105
Cdd:COG3840   23 AAGERVAILGPSGAGKSTLLNLIAGFLPPDSGRILWNGQDL------TALPPAERPVSMLFQENNLFPHLTVAQNIGLGL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 106 R-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIV 184
Cdd:COG3840   97 RpGLKLTAEQRAQVEQALERVGLAGLLDRLPGQLSGGQRQRVALARCLVRKRPILLLDEPFSALDPALRQEMLDLVDELC 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 185 HSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:COG3840  177 RERGLTVLMVTHDPEDAARIADRVLLVADGRIAADGPTAALLDGEPPPALAAYLG 231

DppF

COG1124

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

3-233

5.74e-65

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440741 [Multi-domain] Cd Length: 248 Bit Score: 205.42 E-value: 5.74e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGK----TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKiktsPH 78
Cdd:COG1124    2 LEVRNLSVSYGQggrrVPVLKDVSLEVAPGESFGLVGESGSGKSTLLRALAGLERPWSGEVTFDGRPVTRRRRK----AF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDF--ALWPHMNVFENVAFGLRATKQTNQlREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:COG1124   78 RRRVQMVFQDPyaSLHPRHTVDRILAEPLRIHGLPDR-EERIAELLEQVGLpPSFLDRYPHQLSGGQRQRVAIARALILE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 156 PHFILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDqTEAMS-MSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:COG1124  157 PELLLLDEPTSALDVSVQAEiLNL-LKDLREERGLTYLFVSHD-LAVVAhLCDRVAVMQNGRIVEELTVADLLAGPKHPY 234

FtsE

COG2884

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

3-216

1.92e-64

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442130 [Multi-domain] Cd Length: 223 Bit Score: 202.98 E-value: 1.92e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF-GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTS---PH 78
Cdd:COG2884    2 IRFENVSKRYpGGREALSDVSLEIEKGEFVFLTGPSGAGKSTLLKLLYGEERPTSGQVLVNGQ----DLSRLKRReipYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFENVAFGLRAT-KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:COG2884   78 RRRIGVVFQDFRLLPDRTVYENVALPLRVTgKSRKEIRRRVREVLDLVGLSDKAKALPHELSGGEQQRVAIARALVNRPE 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 158 FILFDEPLSALDailrEEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG2884  158 LLLADEPTGNLD----PETSWEIMELLEEInrrGTTVLIATHDLELVDRMPKRVLELEDGRL 215

EcfA2

COG1122

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ...

13-226

3.63e-64

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 202.56 E-value: 3.63e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMY-SSAKKIKtspheRNIGMVFQD--- 88
Cdd:COG1122   12 GGTPALDDVSLSIEKGEFVAIIGPNGSGKSTLLRLLNGLLKPTSGEVLVDGKDITkKNLRELR-----RKVGLVFQNpdd 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  89 --FAlwphMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:COG1122   87 qlFA----PTVEEDVAFGPENLGLPrEEIRERVEEALELVGLEHLADRPPHELSGGQKQRVAIAGVLAMEPEVLVLDEPT 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 166 SALDAilreEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:COG1122  163 AGLDP----RGRRELLELLKRLnkeGKTVIIVTHDLDLVAELADRVIVLDDGRIVADGTPREVF 222

CcmA

COG1131

ABC-type multidrug transport system, ATPase component [Defense mechanisms];

3-225

8.52e-64

ABC-type multidrug transport system, ATPase component [Defense mechanisms];

Pssm-ID: 440746 [Multi-domain] Cd Length: 236 Bit Score: 201.83 E-value: 8.52e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtspheRNI 82
Cdd:COG1131    1 IEVRGLTKRYGDKTALDGVSLTVEPGEIFGLLGPNGAGKTTTIRMLLGLLRPTSGEVRVLGEDVARDPAEVR-----RRI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAF--GLRATKQtNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG1131   76 GYVPQEPALYPDLTVRENLRFfaRLYGLPR-KEARERIDELLELFGLTDAADRKVGTLSGGMKQRLGLALALLHDPELLI 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 161 FDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG1131  155 LDEPTSGLDPEARRELWELLRELAAE-GKTVLLSTHYLEEAERLCDRVAIIDKGRIVADGTPDEL 218

ABC_NikE_OppD_transporters

cd03257

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...

3-220

4.77e-61

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.

Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 194.65 E-value: 4.77e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtSPH 78
Cdd:cd03257    2 LEVKNLSVSFptggGSVKALDDVSFSIKKGETLGLVGESGSGKSTLARAILGLLKPTSGSIIFDGKDLLKLSRRLR-KIR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQD--FALWPHMNVFENVAFGLRAtkqtnQLREKVEDAIKRVRLQGME---------KRYPHELSGGQQQRVA 147
Cdd:cd03257   81 RKEIQMVFQDpmSSLNPRMTIGEQIAEPLRI-----HGKLSKKEARKEAVLLLLVgvglpeevlNRYPHELSGGQRQRVA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03257  156 IARALALNPKLLIADEPTSALDVSVQAQiLDL-LKKLQEELGLTLLFITHDLGVVAKIADRVAVMYAGKIVEEG 228

modC_ABC

TIGR02142

molybdenum ABC transporter, ATP-binding protein; This model represents the ATP-binding ...

29-229

2.04e-60

molybdenum ABC transporter, ATP-binding protein; This model represents the ATP-binding cassette (ABC) protein of the three subunit molybdate ABC transporter. The three proteins of this complex are homologous to proteins of the sulfate ABC transporter. Molybdenum may be used in nitrogenases of nitrogen-fixing bacteria and in molybdopterin cofactors. In some cases, molybdate may be transported by a sulfate transporter rather than by a specific molybdate transporter. [Transport and binding proteins, Anions]

Pssm-ID: 131197 [Multi-domain] Cd Length: 354 Bit Score: 196.87 E-value: 2.04e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   29 EFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFGLRat 108
Cdd:TIGR02142  24 GVTAIFGRSGSGKTTLIRLIAGLTRPDEGEIVLNGRTLFDSRKGIFLPPEKRRIGYVFQEARLFPHLSVRGNLRYGMK-- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  109 KQTNQLREKVEDAIkrVRLQGME---KRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVH 185
Cdd:TIGR02142 102 RARPSERRISFERV--IELLGIGhllGRLPGRLSGGEKQRVAIGRALLSSPRLLLMDEPLAALDDPRKYEILPYLERLHA 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 446273968  186 SIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:TIGR02142 180 EFGIPILYVSHSLQEVLRLADRVVVLEDGRVAAAGPIAEVWASP 223

TauB

COG4525

ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism];

15-211

7.54e-60

ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443596 [Multi-domain] Cd Length: 262 Bit Score: 192.77 E-value: 7.54e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHERniGMVFQDFALWPH 94
Cdd:COG4525   20 QPALQDVSLTIESGEFVVALGASGCGKTTLLNLIAGFLAPSSGEITLDG-------VPVTGPGADR--GVVFQKDALLPW 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFENVAFGLRATKQTNQLREKV-EDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILR 173
Cdd:COG4525   91 LNVLDNVAFGLRLRGVPKAERRARaEELLALVGLADFARRRIWQLSGGMRQRVGIARALAADPRFLLMDEPFGALDALTR 170

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 446273968 174 EEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVM 211
Cdd:COG4525  171 EQMQELLLDVWQRTGKGVFLITHSVEEALFLATRLVVM 208

FepC

COG1120

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ...

3-225

8.24e-59

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism];

Pssm-ID: 440737 [Multi-domain] Cd Length: 254 Bit Score: 189.48 E-value: 8.24e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT-SPHE-- 79
Cdd:COG1120    2 LEAENLSVGYGGRPVLDDVSLSLPPGEVTALLGPNGSGKSTLLRALAGLLKPSSGEVLLDG-------RDLASlSRREla 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDFALWPHMNVFENVAFGLRA-----TKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVT 154
Cdd:COG1120   75 RRIAYVPQEPPAPFGLTVRELVALGRYPhlglfGRPSAEDREAVEEALERTGLEHLADRPVDELSGGERQRVLIARALAQ 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 155 KPHFILFDEPLSALDaiLReeMRLELMDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG1120  155 EPPLLLLDEPTSHLD--LA--HQLEVLELLRRLarerGRTVVMVLHDLNLAARYADRLVLLKDGRIVAQGPPEEV 225

glnQ

PRK09493

glutamine ABC transporter ATP-binding protein GlnQ;

3-237

5.49e-58

glutamine ABC transporter ATP-binding protein GlnQ;

Pssm-ID: 181906 [Multi-domain] Cd Length: 240 Bit Score: 187.22 E-value: 5.49e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKiktsphERNI 82
Cdd:PRK09493   2 IEFKNVSKHFGPTQVLHNIDLNIDQGEVVVIIGPSGSGKSTLLRCINKLEEITSGDLIVDGLKVNDPKVD------ERLI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 ----GMVFQDFALWPHMNVFENVAFGLRATKQTN--QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:PRK09493  76 rqeaGMVFQQFYLFPHLTALENVMFGPLRVRGASkeEAEKQARELLAKVGLAERAHHYPSELSGGQQQRVAIARALAVKP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 157 HFILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAK 236
Cdd:PRK09493 156 KLMLFDEPTSALDPELRHEV-LKVMQDLAEEGMTMVIVTHEIGFAEKVASRLIFIDKGRIAEDGDPQVLIKNPPSQRLQE 234


                 .
gi 446273968 237 F 237
Cdd:PRK09493 235 F 235

NatA

COG4555

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ...

3-225

6.24e-57

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism];

Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 184.29 E-value: 6.24e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssAKKIKTSPHERNI 82
Cdd:COG4555    2 IEVENLSKKYGKVPALKDVSFTAKDGEITGLLGPNGAGKTTLLRMLAGLLKPDSGSILIDGE-----DVRKEPREARRQI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:COG4555   77 GVLPDERGLYDRLTVRENIRYFAELYGLFdEELKKRIEELIELLGLEEFLDRRVGELSTGMKKKVALARALVHDPKVLLL 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4555  157 DEPTNGLDVMARRLLREILRALKKE-GKTVLFSSHIMQEVEALCDRVVILHKGKVVAQGSLDEL 219

PhnC

COG3638

ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and ...

3-225

7.87e-57

ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 442855 [Multi-domain] Cd Length: 249 Bit Score: 184.49 E-value: 7.87e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF-GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPHERN 81
Cdd:COG3638    3 LELRNLSKRYpGGTPALDDVSLEIERGEFVALIGPSGAGKSTLLRCLNGLVEPTSGEILVDGQDV-TALRGRALRRLRRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFG-------LRAT--KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAI 152
Cdd:COG3638   82 IGMIFQQFNLVPRLSVLTNVLAGrlgrtstWRSLlgLFPPEDRERALEALERVGLADKAYQRADQLSGGQQQRVAIARAL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 153 VTKPHFILFDEPLSALDAIL-REEMRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG3638  162 VQEPKLILADEPVASLDPKTaRQVMDL-LRRIAREDGITVVVNLHQVDLARRYADRIIGLRDGRVVFDGPPAEL 234

AbcC

COG1135

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];

3-239

1.32e-56

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 186.82 E-value: 1.32e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF----GKTQALKP--LQIvmKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT- 75
Cdd:COG1135    2 IELENLSKTFptkgGPVTALDDvsLTI--EKGEIFGIIGYSGAGKSTLIRCINLLERPTSGSVLVDG-------VDLTAl 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SPHE-----RNIGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFA 149
Cdd:COG1135   73 SERElraarRKIGMIFQHFNLLSSRTVAENVALPLEIAGVPkAEIRKRVAELLELVGLSDKADAYPSQLSGGQKQRVGIA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 150 RAIVTKPHFILFDEPLSALD-----AILreemRLeLMDIVHSIGLTALYVTHDqteamsMS------DQIIVMKQGEVLQ 218
Cdd:COG1135  153 RALANNPKVLLCDEATSALDpettrSIL----DL-LKDINRELGLTIVLITHE------MDvvrricDRVAVLENGRIVE 221

                        250       260
                 ....*....|....*....|.
gi 446273968 219 KGTPEDIYVKPSHEFVAKFVG 239
Cdd:COG1135  222 QGPVLDVFANPQSELTRRFLP 242

YnjD

COG4136

ABC-type uncharacterized transport system YnjBCD, ATPase component [General function ...

18-211

1.38e-56

ABC-type uncharacterized transport system YnjBCD, ATPase component [General function prediction only];

Pssm-ID: 443311 [Multi-domain] Cd Length: 211 Bit Score: 182.30 E-value: 1.38e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD---KGEIYFGDTCMYSSAkkiktsPHERNIGMVFQDFALWPH 94
Cdd:COG4136   17 LAPLSLTVAPGEILTLMGPSGSGKSTLLAAIAGTLSPAfsaSGEVLLNGRRLTALP------AEQRRIGILFQDDLLFPH 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFENVAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILRE 174
Cdd:COG4136   91 LSVGENLAFALPPTIGRAQRRARVEQALEEAGLAGFADRDPATLSGGQRARVALLRALLAEPRALLLDEPFSKLDAALRA 170

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446273968 175 EMRLELMDIVHSIGLTALYVTHDQTEAMSMSdQIIVM 211
Cdd:COG4136  171 QFREFVFEQIRQRGIPALLVTHDEEDAPAAG-RVLDL 206

ABC_cobalt_CbiO_domain1

cd03225

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ...

13-215

1.48e-56

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 182.28 E-value: 1.48e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTspheRNIGMVFQD---- 88
Cdd:cd03225   12 GARPALDDISLTIKKGEFVLIVGPNGSGKSTLLRLLNGLLGPTSGEVLVDGKDLTKLSLKELR----RKVGLVFQNpddq 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  89 -FALwphmNVFENVAFGLRATKQTN-QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:cd03225   88 fFGP----TVEEEVAFGLENLGLPEeEIEERVEEALELVGLEGLRDRSPFTLSGGQKQRVAIAGVLAMDPDILLLDEPTA 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446273968 167 ALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:cd03225  164 GLDPAGRREL-LELLKKLKAEGKTIIIVTHDLDLLLELADRVIVLEDGK 211

ABC_PhnC_transporter

cd03256

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ...

3-228

9.44e-56

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 181.23 E-value: 9.44e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFG-KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPHERN 81
Cdd:cd03256    1 IEVENLSKTYPnGKKALKDVSLSINPGEFVALIGPSGAGKSTLLRCLNGLVEPTSGSVLIDGTDI-NKLKGKALRQLRRQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATKQTNQL---------REKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAI 152
Cdd:cd03256   80 IGMIFQQFNLIERLSVLENVLSGRLGRRSTWRSlfglfpkeeKQRALAALERVGLLDKAYQRADQLSGGQQQRVAIARAL 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 153 VTKPHFILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:cd03256  160 MQQPKLILADEPVASLDPASSRQvMDL-LKRINREEGITVIVSLHQVDLAREYADRIVGLKDGRIVFDGPPAELTDE 235

ABC_PstB_phosphate_transporter

cd03260

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ...

3-225

3.83e-54

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD).

Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 176.60 E-value: 3.83e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEE-----PDKGEIYFGDTCMYSSAKKIKTsp 77
Cdd:cd03260    1 IELRDLNVYYGDKHALKDISLDIPKGEITALIGPSGCGKSTLLRLLNRLNDlipgaPDEGEVLLDGKDIYDLDVDVLE-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HERNIGMVFQDFALWPhMNVFENVAFGLRA--TKQTNQLREKVEDAIKRVRLQGMEKR--YPHELSGGQQQRVAFARAIV 153
Cdd:cd03260   79 LRRRVGMVFQKPNPFP-GSIYDNVAYGLRLhgIKLKEELDERVEEALRKAALWDEVKDrlHALGLSGGQQQRLCLARALA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 154 TKPHFILFDEPLSALDAILREEMRLELMDIVHSIglTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:cd03260  158 NEPEVLLLDEPTSALDPISTAKIEELIAELKKEY--TIVIVTHNMQQAARVADRTAFLLNGRLVEFGPTEQI 227

ABC_Mj1267_LivG_branched

cd03219

ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ...

3-225

4.15e-54

ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).

Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 176.86 E-value: 4.15e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT-SPHERN 81
Cdd:cd03219    1 LEVRGLTKRFGGLVALDDVSFSVRPGEIHGLIGPNGAGKTTLFNLISGFLRPTSGSVLFDG-------EDITGlPPHEIA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 ---IGMVFQDFALWPHMNVFENVAFGLRATKQTN-----------QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVA 147
Cdd:cd03219   74 rlgIGRTFQIPRLFPELTVLENVMVAAQARTGSGlllararreerEARERAEELLERVGLADLADRPAGELSYGQQRRLE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 148 FARAIVTKPHFILFDEPLsaldAILREEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPED 224
Cdd:cd03219  154 IARALATDPKLLLLDEPA----AGLNPEETEELAELIRELrerGITVLLVEHDMDVVMSLADRVTVLDQGRVIAEGTPDE 229


                 .
gi 446273968 225 I 225
Cdd:cd03219  230 V 230

3a0107s01c2

TIGR00972

phosphate ABC transporter, ATP-binding protein; This model represents the ATP-binding protein ...

3-238

3.19e-53

phosphate ABC transporter, ATP-binding protein; This model represents the ATP-binding protein of a family of ABC transporters for inorganic phosphate. In the model species Escherichia coli, a constitutive transporter for inorganic phosphate, with low affinity, is also present. The high affinity transporter that includes this polypeptide is induced when extracellular phosphate concentrations are low. The proteins most similar to the members of this family but not included appear to be amino acid transporters. [Transport and binding proteins, Anions]

Pssm-ID: 273372 [Multi-domain] Cd Length: 247 Bit Score: 175.18 E-value: 3.19e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEE-----PDKGEIYFGDTCMYSsaKKIKTSP 77
Cdd:TIGR00972   2 IEIENLNLFYGEKEALKNINLDIPKNQVTALIGPSGCGKSTLLRSLNRMNDlvpgvRIEGKVLFDGQDIYD--KKIDVVE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   78 HERNIGMVFQDFALWPhMNVFENVAFGLRA--TKQTNQLREKVEDAIKRVRLQGMEK----RYPHELSGGQQQRVAFARA 151
Cdd:TIGR00972  80 LRRRVGMVFQKPNPFP-MSIYDNIAYGPRLhgIKDKKELDEIVEESLKKAALWDEVKdrlhDSALGLSGGQQQRLCIARA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  152 IVTKPHFILFDEPLSALDAILREEMrLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSH 231
Cdd:TIGR00972 159 LAVEPEVLLLDEPTSALDPIATGKI-EELIQELKK-KYTIVIVTHNMQQAARISDRTAFFYDGELVEYGPTEQIFTNPKE 236


                  ....*..
gi 446273968  232 EFVAKFV 238
Cdd:TIGR00972 237 KRTEDYI 243

ntrCD

TIGR01184

nitrate transport ATP-binding subunits C and D; This model describes the ATP binding subunits ...

18-214

7.86e-52

nitrate transport ATP-binding subunits C and D; This model describes the ATP binding subunits of nitrate transport in bacteria and archaea. This protein belongs to the ATP-binding cassette (ABC) superfamily. It is thought that the two subunits encoded by ntrC and ntrD form the binding surface for interaction with ATP. This model is restricted in identifying ATP binding subunit associated with the nitrate transport. Nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA - a regulatory protein; ntrB - a hydropbobic transmembrane permease and narB - a reductase. [Transport and binding proteins, Anions, Transport and binding proteins, Other]

Pssm-ID: 130252 [Multi-domain] Cd Length: 230 Bit Score: 171.11 E-value: 7.86e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKTSPHERNIgmVFQDFALWPHMNV 97
Cdd:TIGR01184   1 LKGVNLTIQQGEFISLIGHSGCGKSTLLNLISGLAQPTSGGVIL-------EGKQITEPGPDRMV--VFQNYSLLPWLTV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   98 FENVAFGL---RATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILRE 174
Cdd:TIGR01184  72 RENIALAVdrvLPDLSKSERRAIVEEHIALVGLTEAADKRPGQLSGGMKQRVAIARALSIRPKVLLLDEPFGALDALTRG 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 446273968  175 EMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:TIGR01184 152 NLQEELMQIWEEHRVTVLMVTHDVDEALLLSDRVVMLTNG 191

ArtP

COG4161

ABC-type arginine transport system, ATPase component [Amino acid transport and metabolism];

1-237

8.87e-52

ABC-type arginine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443326 [Multi-domain] Cd Length: 242 Bit Score: 171.35 E-value: 8.87e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKkiktsPHE- 79
Cdd:COG4161    1 MSIQLKNINCFYGSHQALFDINLECPSGETLVLLGPSGAGKSSLLRVLNLLETPDSGQLNIAGHQFDFSQK-----PSEk 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 ------RNIGMVFQDFALWPHMNVFEN-VAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARA 151
Cdd:COG4161   76 airllrQKVGMVFQQYNLWPHLTVMENlIEAPCKVLGLSkEQAREKAMKLLARLRLTDKADRFPLHLSGGQQQRVAIARA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IVTKPHFILFDEPLSALDAilreEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEdIYVK 228
Cdd:COG4161  156 LMMEPQVLLFDEPTAALDP----EITAQVVEIIRELsqtGITQVIVTHEVEFARKVASQVVYMEKGRIIEQGDAS-HFTQ 230


                 ....*....
gi 446273968 229 PSHEFVAKF 237
Cdd:COG4161  231 PQTEAFAHY 239

GsiA

COG1123

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...

3-229

9.36e-52

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 178.56 E-value: 9.36e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF--GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD---KGEIYFGDTCMYssakkiKTSP 77
Cdd:COG1123    5 LEVRDLSVRYpgGDVPAVDGVSLTIAPGETVALVGESGSGKSTLALALMGLLPHGgriSGEVLLDGRDLL------ELSE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HER--NIGMVFQDF--ALWPhMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAI 152
Cdd:COG1123   79 ALRgrRIGMVFQDPmtQLNP-VTVGDQIAEALENLGLSrAEARARVLELLEAVGLERRLDRYPHQLSGGQRQRVAIAMAL 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 153 VTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:COG1123  158 ALDPDLLIADEPTTALDVTTQAEILDLLRELQRERGTTVLLITHDLGVVAEIADRVVVMDDGRIVEDGPPEEILAAP 234

ABC_FtsE

cd03292

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ...

13-216

1.05e-51

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages

Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 170.28 E-value: 1.05e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPHERNIGMVFQDFALW 92
Cdd:cd03292   12 NGTAALDGINISISAGEFVFLVGPSGAGKSTLLKLIYKEELPTSGTIRVNGQDV-SDLRGRAIPYLRRKIGVVFQDFRLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHMNVFENVAFGLRATKQTNQL-REKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAI 171
Cdd:cd03292   91 PDRNVYENVAFALEVTGVPPREiRKRVPAALELVGLSHKHRALPAELSGGEQQRVAIARAIVNSPTILIADEPTGNLDPD 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446273968 172 LREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03292  171 TTWEI-MNLLKKINKAGTTVVVATHAKELVDTTRHRVIALERGKL 214

ABC_MetN_methionine_transporter

cd03258

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ...

3-230

2.02e-51

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 170.07 E-value: 2.02e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFG----KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPH 78
Cdd:cd03258    2 IELKNVSKVFGdtggKVTALKDVSLSVPKGEIFGIIGRSGAGKSTLIRCINGLERPTSGSVLVDGTDL-TLLSGKELRKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:cd03258   81 RRRIGMIFQHFNLLSSRTVFENVALPLEIAGVPkAEIEERVLELLELVGLEDKADAYPAQLSGGQKQRVGIARALANNPK 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 158 FILFDEPLSALDAILREEMrLELM-DIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPS 230
Cdd:cd03258  161 VLLCDEATSALDPETTQSI-LALLrDINRELGLTIVLITHEMEVVKRICDRVAVMEKGEVVEEGTVEEVFANPQ 233

HisP

COG4598

ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism];

3-237

2.13e-51

ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443652 [Multi-domain] Cd Length: 259 Bit Score: 170.75 E-value: 2.13e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTSPHER- 80
Cdd:COG4598    9 LEVRDLHKSFGDLEVLKGVSLTARKGDVISIIGSSGSGKSTFLRCINLLETPDSGEIRVgGEEIRLKPDRDGELVPADRr 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 -------NIGMVFQDFALWPHMNVFENVAFG----LRATKQtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFA 149
Cdd:COG4598   89 qlqrirtRLGMVFQSFNLWSHMTVLENVIEApvhvLGRPKA--EAIERAEALLAKVGLADKRDAYPAHLSGGQQQRAAIA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 150 RAIVTKPHFILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:COG4598  167 RALAMEPEVMLFDEPTSALDPELVGEV-LKVMRDLAEEGRTMLVVTHEMGFARDVSSHVVFLHQGRIEEQGPPAEVFGNP 245


                 ....*...
gi 446273968 230 SHEFVAKF 237
Cdd:COG4598  246 KSERLRQF 253

ABC_DR_subfamily_A

cd03230

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ...

3-216

1.05e-50

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 166.03 E-value: 1.05e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtspheRNI 82
Cdd:cd03230    1 IEVRNLSKRYGKKTALDDISLTVEKGEIYGLLGPNGAGKTTLIKIILGLLKPDSGEIKVLGKDIKKEPEEVK-----RRI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVafglratkqtnqlrekvedaikrvrlqgmekryphELSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:cd03230   76 GYLPEEPSLYENLTVRENL-----------------------------------KLSGGMKQRLALAQALLHDPELLILD 120

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446273968 163 EPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03230  121 EPTSGLDPESRREFWELLRELKKE-GKTILLSSHILEEAERLCDRVAILNNGRI 173

artP

PRK11124

arginine transporter ATP-binding subunit; Provisional

1-221

1.23e-50

arginine transporter ATP-binding subunit; Provisional

Pssm-ID: 182980 [Multi-domain] Cd Length: 242 Bit Score: 168.27 E-value: 1.23e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEI-----YFgDTCMYSSAKKIKT 75
Cdd:PRK11124   1 MSIQLNGINCFYGAHQALFDITLDCPQGETLVLLGPSGAGKSSLLRVLNLLEMPRSGTLniagnHF-DFSKTPSDKAIRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SphERNIGMVFQDFALWPHMNVFENV------AFGLraTKQtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFA 149
Cdd:PRK11124  80 L--RRNVGMVFQQYNLWPHLTVQQNLieapcrVLGL--SKD--QALARAEKLLERLRLKPYADRFPLHLSGGQQQRVAIA 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 150 RAIVTKPHFILFDEPLSALDAilreEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGT 221
Cdd:PRK11124 154 RALMMEPQVLLFDEPTAALDP----EITAQIVSIIRELaetGITQVIVTHEVEVARKTASRVVYMENGHIVEQGD 224

ssuB

PRK11247

aliphatic sulfonates transport ATP-binding subunit; Provisional

5-216

1.99e-50

aliphatic sulfonates transport ATP-binding subunit; Provisional

Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 168.32 E-value: 1.99e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   5 ISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKiktspherNIGM 84
Cdd:PRK11247  15 LNAVSKRYGERTVLNQLDLHIPAGQFVAVVGRSGCGKSTLLRLLAGLETPSAGELLAGTAPL-AEARE--------DTRL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VFQDFALWPHMNVFENVAFGLRAtkqtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:PRK11247  86 MFQDARLLPWKKVIDNVGLGLKG-----QWRDAALQALAAVGLADRANEWPAALSGGQKQRVALARALIHRPGLLLLDEP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 165 LSALDAILREEMRlelmDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PRK11247 161 LGALDALTRIEMQ----DLIESLwqqhGFTVLLVTHDVSEAVAMADRVLLIEEGKI 212

ECF_ATPase_1

TIGR04520

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ...

3-230

2.93e-50

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]

Pssm-ID: 275313 [Multi-domain] Cd Length: 268 Bit Score: 167.99 E-value: 2.93e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNF--GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIKtsph 78
Cdd:TIGR04520   1 IEVENVSFSYpeSEKPALKNVSLSIEKGEFVAIIGHNGSGKSTLAKLLNGLLLPTSGKVTVDglDTLDEENLWEIR---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   79 eRNIGMVFQDfalwPHmNVF------ENVAFGL--RATKqTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFAR 150
Cdd:TIGR04520  77 -KKVGMVFQN----PD-NQFvgatveDDVAFGLenLGVP-REEMRKRVDEALKLVGMEDFRDREPHLLSGGQKQRVAIAG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  151 AIVTKPHFILFDEPLSALDAILREemrlELMDIVHSI----GLTALYVTHDQTEAMsMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:TIGR04520 150 VLAMRPDIIILDEATSMLDPKGRK----EVLETIRKLnkeeGITVISITHDMEEAV-LADRVIVMNKGKIVAEGTPREIF 224


                  ....
gi 446273968  227 VKPS 230
Cdd:TIGR04520 225 SQVE 228

ABC_phnC

TIGR02315

phosphonate ABC transporter, ATP-binding protein; Phosphonates are a class of ...

3-226

5.59e-50

phosphonate ABC transporter, ATP-binding protein; Phosphonates are a class of phosphorus-containing organic compound with a stable direct C-P bond rather than a C-O-P linkage. A number of bacterial species have operons, typically about 14 genes in size, with genes for ATP-dependent transport of phosphonates, degradation, and regulation of the expression of the system. Members of this protein family are the ATP-binding cassette component of tripartite ABC transporters of phosphonates. [Transport and binding proteins, Anions]

Pssm-ID: 131368 [Multi-domain] Cd Length: 243 Bit Score: 166.70 E-value: 5.59e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGK-TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTspHER 80
Cdd:TIGR02315   2 LEVENLSKVYPNgKQALKNINLNINPGEFVAIIGPSGAGKSTLLRCINRLVEPSSGSILLeGTDITKLRGKKLRK--LRR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   81 NIGMVFQDFALWPHMNVFENVAFGLRATKQTNQL---------REKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARA 151
Cdd:TIGR02315  80 RIGMIFQHYNLIERLTVLENVLHGRLGYKPTWRSllgrfseedKERALSALERVGLADKAYQRADQLSGGQQQRVAIARA 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968  152 IVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:TIGR02315 160 LAQQPDLILADEPIASLDPKTSKQVMDYLKRINKEDGITVIINLHQVDLAKKYADRIVGLKAGEIVFDGAPSELD 234

ABC_ThiQ_thiamine_transporter

cd03298

ATP-binding cassette domain of the thiamine transport system; Part of the ...

27-220

5.69e-50

ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213265 [Multi-domain] Cd Length: 211 Bit Score: 165.36 E-value: 5.69e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  27 QGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSakkiktSPHERNIGMVFQDFALWPHMNVFENVAFGLR 106
Cdd:cd03298   23 QGEITAIVGPSGSGKSTLLNLIAGFETPQSGRVLINGVDVTAA------PPADRPVSMLFQENNLFAHLTVEQNVGLGLS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 107 AT-KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVH 185
Cdd:cd03298   97 PGlKLTAEDRQAIEVALARVGLAGLEKRLPGELSGGERQRVALARVLVRDKPVLLLDEPFAALDPALRAEMLDLVLDLHA 176

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446273968 186 SIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03298  177 ETKMTVLMVTHQPEDAKRLAQRVVFLDNGRIAAQG 211

tauB

PRK11248

taurine ABC transporter ATP-binding subunit;

3-214

6.02e-50

taurine ABC transporter ATP-binding subunit;

Pssm-ID: 183056 [Multi-domain] Cd Length: 255 Bit Score: 166.80 E-value: 6.02e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGdtcmyssAKKIKTSPHERni 82
Cdd:PRK11248   2 LQISHLYADYGGKPALEDINLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSITLD-------GKPVEGPGAER-- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:PRK11248  73 GVVFQNEGLLPWRNVQDNVAFGLQlAGVEKMQRLEIAHQMLKKVGLEGAEKRYIWQLSGGQRQRVGIARALAANPQLLLL 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:PRK11248 153 DEPFGALDAFTREQMQTLLLKLWQETGKQVLLITHDIEEAVFMATELVLLSPG 205

FetA

COG4619

ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];

3-216

4.79e-49

ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443661 [Multi-domain] Cd Length: 209 Bit Score: 163.06 E-value: 4.79e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSakkiktSPHE--R 80
Cdd:COG4619    1 LELEGLSFRVGGKPILSPVSLTLEAGECVAITGPSGSGKSTLLRALADLDPPTSGEIYLDGKPLSAM------PPPEwrR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPhMNVFENVAFGLRATKQTNQlREKVEDAIKRVRLQG--MEKRYpHELSGGQQQRVAFARAIVTKPHF 158
Cdd:COG4619   75 QVAYVPQEPALWG-GTVRDNLPFPFQLRERKFD-RERALELLERLGLPPdiLDKPV-ERLSGGERQRLALIRALLLQPDV 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 159 ILFDEPLSALDAILREemRLE--LMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG4619  152 LLLDEPTSALDPENTR--RVEelLREYLAEEGRAVLWVSHDPEQIERVADRVLTLEAGRL 209

PRK11264

putative amino-acid ABC transporter ATP-binding protein YecC; Provisional

3-240

5.16e-49

putative amino-acid ABC transporter ATP-binding protein YecC; Provisional

Pssm-ID: 183063 [Multi-domain] Cd Length: 250 Bit Score: 164.15 E-value: 5.16e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG----DTCMYSSAKKIKTSPH 78
Cdd:PRK11264   4 IEVKNLVKKFHGQTVLHGIDLEVKPGEVVAIIGPSGSGKTTLLRCINLLEQPEAGTIRVGditiDTARSLSQQKGLIRQL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFENVAFGLRATKqtnqlREKVEDAIKRVR-------LQGMEKRYPHELSGGQQQRVAFARA 151
Cdd:PRK11264  84 RQHVGFVFQNFNLFPHRTVLENIIEGPVIVK-----GEPKEEATARARellakvgLAGKETSYPRRLSGGQQQRVAIARA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IVTKPHFILFDEPLSALDAilreEMRLELMDIVHSIG---LTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:PRK11264 159 LAMRPEVILFDEPTSALDP----ELVGEVLNTIRQLAqekRTMVIVTHEMSFARDVADRAIFMDQGRIVEQGPAKALFAD 234

                        250
                 ....*....|....*.
gi 446273968 229 PSHE----FVAKFVGK 240
Cdd:PRK11264 235 PQQPrtrqFLEKFLLQ 250

DppD

COG0444

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

3-231

2.67e-48

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440213 [Multi-domain] Cd Length: 320 Bit Score: 164.46 E-value: 2.67e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEP---DKGEIYFGDTCMyssakkIKT 75
Cdd:COG0444    2 LEVRNLKVYFptrrGVVKAVDGVSFDVRRGETLGLVGESGSGKSTLARAILGLLPPpgiTSGEILFDGEDL------LKL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SPHE------RNIGMVFQDF--ALWPHMNVFENVAFGLRATKQTN--QLREKVEDAIKRVRLQGMEKR---YPHELSGGQ 142
Cdd:COG0444   76 SEKElrkirgREIQMIFQDPmtSLNPVMTVGDQIAEPLRIHGGLSkaEARERAIELLERVGLPDPERRldrYPHELSGGM 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 143 QQRVAFARAIVTKPHFILFDEPLSALDAILREE-MRLeLMDIVHSIGLTALYVTHDqteaMS----MSDQIIVMKQGEVL 217
Cdd:COG0444  156 RQRVMIARALALEPKLLIADEPTTALDVTIQAQiLNL-LKDLQRELGLAILFITHD----LGvvaeIADRVAVMYAGRIV 230

                        250
                 ....*....|....
gi 446273968 218 QKGTPEDIYVKPSH 231
Cdd:COG0444  231 EEGPVEELFENPRH 244

LivG

COG0411

ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid ...

4-225

6.35e-48

ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid transport and metabolism];

Pssm-ID: 440180 [Multi-domain] Cd Length: 257 Bit Score: 161.74 E-value: 6.35e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKI-KTSPHERN- 81
Cdd:COG0411    6 EVRGLTKRFGGLVAVDDVSLEVERGEIVGLIGPNGAGKTTLFNLITGFYRPTSGRILFDG-------RDItGLPPHRIAr 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMV--FQDFALWPHMNVFENVAFGL----------------RATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQ 143
Cdd:COG0411   79 LGIArtFQNPRLFPELTVLENVLVAAharlgrgllaallrlpRARREEREARERAEELLERVGLADRADEPAGNLSYGQQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 144 QRVAFARAIVTKPHFILFDEPLSALDAilrEEMRlELMDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQK 219
Cdd:COG0411  159 RRLEIARALATEPKLLLLDEPAAGLNP---EETE-ELAELIRRLrderGITILLIEHDMDLVMGLADRIVVLDFGRVIAE 234


                 ....*.
gi 446273968 220 GTPEDI 225
Cdd:COG0411  235 GTPAEV 240

PRK10070

proline/glycine betaine ABC transporter ATP-binding protein ProV;

8-237

7.30e-48

proline/glycine betaine ABC transporter ATP-binding protein ProV;

Pssm-ID: 182221 [Multi-domain] Cd Length: 400 Bit Score: 165.59 E-value: 7.30e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   8 LEKNfGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQ 87
Cdd:PRK10070  35 LEKT-GLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQ 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  88 DFALWPHMNVFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:PRK10070 114 SFALMPHMTVLDNTAFGMElAGINAEERREKALDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFS 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 167 ALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKF 237
Cdd:PRK10070 194 ALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTF 264

YejF

COG4172

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...

12-232

1.02e-47

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 167.94 E-value: 1.02e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQ----ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEePDKGEIYFGDTCMYS-SAKKIKtsPHERNIGMVF 86
Cdd:COG4172  292 FRRTVghvkAVDGVSLTLRRGETLGLVGESGSGKSTLGLALLRLI-PSEGEIRFDGQDLDGlSRRALR--PLRRRMQVVF 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  87 QD-FA-LWPHMNVFENVAFGLRA-----TKQtnQLREKVEDAIKRVRLQ-GMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:COG4172  369 QDpFGsLSPRMTVGQIIAEGLRVhgpglSAA--ERRARVAEALEEVGLDpAARHRYPHEFSGGQRQRIAIARALILEPKL 446

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 159 ILFDEPLSALDAILREEMrLELM-DIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHE 232
Cdd:COG4172  447 LVLDEPTSALDVSVQAQI-LDLLrDLQREHGLAYLFISHDLAVVRALAHRVMVMKDGKVVEQGPTEQVFDAPQHP 520

FtsE

TIGR02673

cell division ATP-binding protein FtsE; This model describes FtsE, a member of the ABC ...

3-215

1.17e-47

cell division ATP-binding protein FtsE; This model describes FtsE, a member of the ABC transporter ATP-binding protein family. This protein, and its permease partner FtsX, localize to the division site. In a number of species, the ftsEX gene pair is located next to FtsY, the signal recognition particle-docking protein. [Cellular processes, Cell division]

Pssm-ID: 131721 [Multi-domain] Cd Length: 214 Bit Score: 159.72 E-value: 1.17e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNF-GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEI-YFGDTCMYSSAKKIktsPH-E 79
Cdd:TIGR02673   2 IEFHNVSKAYpGGVAALHDVSLHIRKGEFLFLTGPSGAGKTTLLKLLYGALTPSRGQVrIAGEDVNRLRGRQL---PLlR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   80 RNIGMVFQDFALWPHMNVFENVAFGLRAT-KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:TIGR02673  79 RRIGVVFQDFRLLPDRTVYENVALPLEVRgKKEREIQRRVGAALRQVGLEHKADAFPEQLSGGEQQRVAIARAIVNSPPL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968  159 ILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:TIGR02673 159 LLADEPTGNLDPDLSERI-LDLLKRLNKRGTTVIVATHDLSLVDRVAHRVIILDDGR 214

PstB

COG1117

ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; ...

3-238

2.28e-47

ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440734 [Multi-domain] Cd Length: 258 Bit Score: 160.20 E-value: 2.28e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLL----RMIAglEEPD---KGEIYFGDTCMYSSakkiKT 75
Cdd:COG1117   12 IEVRNLNVYYGDKQALKDINLDIPENKVTALIGPSGCGKSTLLrclnRMND--LIPGarvEGEILLDGEDIYDP----DV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SPHE--RNIGMVFQD---FAlwphMNVFENVAFGLRA--TKQTNQLREKVEDAIKRV--------RLqgmeKRYPHELSG 140
Cdd:COG1117   86 DVVElrRRVGMVFQKpnpFP----KSIYDNVAYGLRLhgIKSKSELDEIVEESLRKAalwdevkdRL----KKSALGLSG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 141 GQQQRVAFARAIVTKPHFILFDEPLSALDAI--LR-EEMRLEL---MDIVhsIgltalyVTHDQTEAMSMSDQIIVMKQG 214
Cdd:COG1117  158 GQQQRLCIARALAVEPEVLLMDEPTSALDPIstAKiEELILELkkdYTIV--I------VTHNMQQAARVSDYTAFFYLG 229

                        250       260
                 ....*....|....*....|....
gi 446273968 215 EVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:COG1117  230 ELVEFGPTEQIFTNPKDKRTEDYI 253

L_ocin_972_ABC

TIGR03608

putative bacteriocin export ABC transporter, lactococcin 972 group; A gene pair with a fairly ...

5-209

2.88e-47

putative bacteriocin export ABC transporter, lactococcin 972 group; A gene pair with a fairly wide distribution consists of a polypeptide related to the lactococcin 972 (see TIGR01653) and multiple-membrane-spanning putative immunity protein (see TIGR01654). This model represents a small clade within the ABC transporters that regularly are found adjacent to these bacteriocin system gene pairs and are likely serve as export proteins. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]

Pssm-ID: 188353 [Multi-domain] Cd Length: 206 Bit Score: 158.16 E-value: 2.88e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    5 ISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcMYSSAKKIKTSPHERN-IG 83
Cdd:TIGR03608   1 LKNISKKFGDKVILDDLNLTIEKGKMYAIIGESGSGKSTLLNIIGLLEKFDSGQVYLNGQ-ETPPLNSKKASKFRREkLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   84 MVFQDFALWPHMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:TIGR03608  80 YLFQNFALIENETVEENLDLGLKYKKLSkKEKREKKKEALEKVGLNLKLKQKIYELSGGEQQRVALARAILKPPPLILAD 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 446273968  163 EPLSALDailrEEMRLELMDIVHSI---GLTALYVTHDqTEAMSMSDQII 209
Cdd:TIGR03608 160 EPTGSLD----PKNRDEVLDLLLELndeGKTIIIVTHD-PEVAKQADRVI 204

AppF

COG4608

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; ...

33-231

2.43e-46

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443658 [Multi-domain] Cd Length: 329 Bit Score: 159.51 E-value: 2.43e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPHERNIGMVFQD-FA-LWPHMNVFENVAFGLR---- 106
Cdd:COG4608   49 LVGESGCGKSTLGRLLLRLEEPTSGEILFDGQDI-TGLSGRELRPLRRRMQMVFQDpYAsLNPRMTVGDIIAEPLRihgl 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 107 ATKQtnQLREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD-AI------LREEMRL 178
Cdd:COG4608  128 ASKA--ERRERVAELLELVGLrPEHADRYPHEFSGGQRQRIGIARALALNPKLIVCDEPVSALDvSIqaqvlnLLEDLQD 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 179 ELmdivhsiGLTALYVTHDqteaMSM----SDQIIVMKQGEVLQKGTPEDIYVKPSH 231
Cdd:COG4608  206 EL-------GLTYLFISHD----LSVvrhiSDRVAVMYLGKIVEIAPRDELYARPLH 251

ABC_Iron-Siderophores_B12_Hemin

cd03214

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ...

4-220

5.68e-46

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.

Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 154.13 E-value: 5.68e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT-SPHE--R 80
Cdd:cd03214    1 EVENLSVGYGGRTVLDDLSLSIEAGEIVGILGPNGAGKSTLLKTLAGLLKPSSGEILLDG-------KDLASlSPKElaR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQdfalwphmnvfenvafglratkqtnqlrekvedAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:cd03214   74 KIAYVPQ---------------------------------ALELLGLAHLADRPFNELSGGERQRVLLARALAQEPPILL 120

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 161 FDEPLSALDaiLReeMRLELMDIV----HSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03214  121 LDEPTSHLD--IA--HQIELLELLrrlaRERGKTVVMVLHDLNLAARYADRVILLKDGRIVAQG 180

thiQ

TIGR01277

thiamine ABC transporter, ATP-binding protein; This model describes the energy-transducing ...

28-220

1.38e-45

thiamine ABC transporter, ATP-binding protein; This model describes the energy-transducing ATPase subunit ThiQ of the ThiBPQ thiamine (and thiamine pyrophosphate) ABC transporter in several Proteobacteria. This protein is found so far only in Proteobacteria, and is found in complete genomes only if the ThiB and ThiP subunits are also found. [Transport and binding proteins, Other]

Pssm-ID: 130344 [Multi-domain] Cd Length: 213 Bit Score: 154.25 E-value: 1.38e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAkkiktsPHERNIGMVFQDFALWPHMNVFENVAFGLRA 107
Cdd:TIGR01277  24 GEIVAIMGPSGAGKSTLLNLIAGFIEPASGSIKVNDQSHTGLA------PYQRPVSMLFQENNLFAHLTVRQNIGLGLHP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  108 TKQTNQL-REKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHS 186
Cdd:TIGR01277  98 GLKLNAEqQEKVVDAAQQVGIADYLDRLPEQLSGGQRQRVALARCLVRPNPILLLDEPFSALDPLLREEMLALVKQLCSE 177

                         170       180       190
                  ....*....|....*....|....*....|....
gi 446273968  187 IGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:TIGR01277 178 RQRTLLMVTHHLSDARAIASQIAVVSQGKIKVVS 211

CcmA

COG4133

ABC-type transport system involved in cytochrome c biogenesis, ATPase component ...

1-201

7.40e-45

ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 152.25 E-value: 7.40e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssAKKIKTSPHER 80
Cdd:COG4133    1 MMLEAENLSCRRGERLLFSGLSFTLAAGEALALTGPNGSGKTTLLRILAGLLPPSAGEVLWNGE-----PIRDAREDYRR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFENVAFgLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG4133   76 RLAYLGHADGLKPELTVRENLRF-WAALYGLRADREAIDEALEAVGLAGLADLPVRQLSAGQKRRVALARLLLSPAPLWL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446273968 161 FDEPLSALD----AILREEMRLELMDivhsiGLTALYVTHDQTEA 201
Cdd:COG4133  155 LDEPFTALDaagvALLAELIAAHLAR-----GGAVLLTTHQPLEL 194

ABC_tran

pfam00005

ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...

18-166

7.79e-45

Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 150.11 E-value: 7.79e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIktspHERNIGMVFQDFALWPHMNV 97
Cdd:pfam00005   1 LKNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDERKS----LRKEIGYVFQDPQLFPRLTV 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968   98 FENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKR----YPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:pfam00005  77 RENLRLGLLLKGlSKREKDARAEEALEKLGLGDLADRpvgeRPGTLSGGQRQRVAIARALLTKPKLLLLDEPTA 150

metN

PRK11153

DL-methionine transporter ATP-binding subunit; Provisional

3-239

9.70e-45

DL-methionine transporter ATP-binding subunit; Provisional

Pssm-ID: 236863 [Multi-domain] Cd Length: 343 Bit Score: 155.73 E-value: 9.70e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYS-SAKKIKTSp 77
Cdd:PRK11153   2 IELKNISKVFpqggRTIHALNNVSLHIPAGEIFGVIGASGAGKSTLIRCINLLERPTSGRVLVDGQDLTAlSEKELRKA- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 hERNIGMVFQDFALWPHMNVFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:PRK11153  81 -RRQIGMIFQHFNLLSSRTVFDNVALPLElAGTPKAEIKARVTELLELVGLSDKADRYPAQLSGGQKQRVAIARALASNP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 157 HFILFDEPLSALD-----AIlreemrLELM-DIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPS 230
Cdd:PRK11153 160 KVLLCDEATSALDpattrSI------LELLkDINRELGLTIVLITHEMDVVKRICDRVAVIDAGRLVEQGTVSEVFSHPK 233


                 ....*....
gi 446273968 231 HEFVAKFVG 239
Cdd:PRK11153 234 HPLTREFIQ 242

ZnuC

COG1121

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ...

3-225

1.08e-44

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 152.94 E-value: 1.08e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHErnI 82
Cdd:COG1121    7 IELENLTVSYGGRPVLEDVSLTIPPGEFVAIVGPNGAGKSTLLKAILGLLPPTSGTVRLFG-------KPPRRARRR--I 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFAL-W--PhMNVFENVAFGL--------RATKQtnqLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARA 151
Cdd:COG1121   78 GYVPQRAEVdWdfP-ITVRDVVLMGRygrrglfrRPSRA---DREAVDEALERVGLEDLADRPIGELSGGQQQRVLLARA 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 152 IVTKPHFILFDEPLSALDAilreEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGeVLQKGTPEDI 225
Cdd:COG1121  154 LAQDPDLLLLDEPFAGVDA----ATEEALYELLRELrreGKTILVVTHDLGAVREYFDRVLLLNRG-LVAHGPPEEV 225

SapF

COG4167

ABC-type antimicrobial peptide export system, ATPase component SapF [Defense mechanisms];

3-258

1.22e-44

ABC-type antimicrobial peptide export system, ATPase component SapF [Defense mechanisms];

Pssm-ID: 443328 [Multi-domain] Cd Length: 265 Bit Score: 153.45 E-value: 1.22e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF---------GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKI 73
Cdd:COG4167    5 LEVRNLSKTFkyrtglfrrQQFEAVKPVSFTLEAGQTLAIIGENGSGKSTLAKMLAGIIEPTSGEILINGHKLEYGDYKY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  74 KTspheRNIGMVFQD--FALWPHMNVFENVAFGLR-ATKQTNQLR-EKVEDAIKRVrlqGM--EKR--YPHELSGGQQQR 145
Cdd:COG4167   85 RC----KHIRMIFQDpnTSLNPRLNIGQILEEPLRlNTDLTAEEReERIFATLRLV---GLlpEHAnfYPHMLSSGQKQR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 146 VAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4167  158 VALARALILQPKIIIADEALAALDMSVRSQIINLMLELQEKLGISYIYVSQHLGIVKHISDKVLVMHQGEVVEYGKTAEV 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 446273968 226 YVKPSHEFVAKfvgkanwLVEGKQMIRPEHVSW 258
Cdd:COG4167  238 FANPQHEVTKR-------LIESHFGEALTADAW 263

modC

PRK11144

molybdenum ABC transporter ATP-binding protein ModC;

31-226

1.90e-44

molybdenum ABC transporter ATP-binding protein ModC;

Pssm-ID: 182993 [Multi-domain] Cd Length: 352 Bit Score: 155.42 E-value: 1.90e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  31 TTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFGLRATKQ 110
Cdd:PRK11144  27 TAIFGRSGAGKTSLINAISGLTRPQKGRIVLNGRVLFDAEKGICLPPEKRRIGYVFQDARLFPHYKVRGNLRYGMAKSMV 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 111 TNQlrekveDAIkrVRLQGME---KRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSI 187
Cdd:PRK11144 107 AQF------DKI--VALLGIEpllDRYPGSLSGGEKQRVAIGRALLTAPELLLMDEPLASLDLPRKRELLPYLERLAREI 178

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 446273968 188 GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK11144 179 NIPILYVSHSLDEILRLADRVVVLEQGKVKAFGPLEEVW 217

thiQ

PRK10771

thiamine ABC transporter ATP-binding protein ThiQ;

26-225

3.76e-44

thiamine ABC transporter ATP-binding protein ThiQ;

Pssm-ID: 182716 [Multi-domain] Cd Length: 232 Bit Score: 151.27 E-value: 3.76e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMyssakkiKTSPHERNIGMVFQDFALWPHMNVFENVAFG 104
Cdd:PRK10771  23 ERGERVAILGPSGAGKSTLLNLIAGFLTPASGSLTLnGQDHT-------TTPPSRRPVSMLFQENNLFSHLTVAQNIGLG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 105 LR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMrLELMD- 182
Cdd:PRK10771  96 LNpGLKLNAAQREKLHAIARQMGIEDLLARLPGQLSGGQRQRVALARCLVREQPILLLDEPFSALDPALRQEM-LTLVSq 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446273968 183 IVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK10771 175 VCQERQLTLLMVSHSLEDAARIAPRSLVVADGRIAWDGPTDEL 217

ECF_ATPase_2

TIGR04521

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ...

15-226

1.09e-43

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the downstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]

Pssm-ID: 275314 [Multi-domain] Cd Length: 277 Bit Score: 151.06 E-value: 1.09e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHeRNIGMVFQD-----F 89
Cdd:TIGR04521  18 KKALDDVSLTIEDGEFVAIIGHTGSGKSTLIQHLNGLLKPTSGTVTIDGRDITAKKKKKLKDLR-KKVGLVFQFpehqlF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   90 ALwphmNVFENVAFGLRATKQTNQ-LREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:TIGR04521  97 EE----TVYKDIAFGPKNLGLSEEeAEERVKEALELVGLdEEYLERSPFELSGGQMRRVAIAGVLAMEPEVLILDEPTAG 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968  168 LDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:TIGR04521 173 LDPKGRKEILDLFKRLHKEKGLTVILVTHSMEDVAEYADRVIVMHKGKIVLDGTPREVF 231

ABC_TM1139_LivF_branched

cd03224

ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ...

3-225

1.12e-43

ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.

Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 149.51 E-value: 1.12e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKI-KTSPHERN 81
Cdd:cd03224    1 LEVENLNAGYGKSQILFGVSLTVPEGEIVALLGRNGAGKTTLLKTIMGLLPPRSGSIRFDG-------RDItGLPPHERA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 ---IGMVFQDFALWPHMNVFENVAFGLRAtkqtnQLREKVEDAIKRV-----RLQGMEKRYPHELSGGQQQRVAFARAIV 153
Cdd:cd03224   74 ragIGYVPEGRRIFPELTVEENLLLGAYA-----RRRAKRKARLERVyelfpRLKERRKQLAGTLSGGEQQMLAIARALM 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 154 TKPHFILFDEPLSALDAILREemrlELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:cd03224  149 SRPKLLLLDEPSEGLAPKIVE----EIFEAIRELrdeGVTILLVEQNARFALEIADRAYVLERGRVVLEGTAAEL 219

ABC_ATPase

cd00267

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...

4-215

1.20e-43

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 147.39 E-value: 1.20e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIG 83
Cdd:cd00267    1 EIENLSFRYGGRTALDNVSLTLKAGEIVALVGPNGSGKSTLLRAIAGLLKPTSGEILIDGK----DIAKLPLEELRRRIG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  84 MVFQdfalwphmnvfenvafglratkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:cd00267   77 YVPQ--------------------------------------------------LSGGQRQRVALARALLLNPDLLLLDE 106

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446273968 164 PLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:cd00267  107 PTSGLDPASRERL-LELLRELAEEGRTVIIVTHDPELAELAADRVIVLKDGK 157

SunT

COG2274

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ...

17-225

1.28e-43

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];

Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 159.23 E-value: 1.28e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIktSPHE--RNIGMVFQDFALWpH 94
Cdd:COG2274  490 VLDNISLTIKPGERVAIVGRSGSGKSTLLKLLLGLYEPTSGRILIDGI----DLRQI--DPASlrRQIGVVLQDVFLF-S 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFENVAFG-LRATkqtnqlREKVEDAIKRVRL----QGMEKRYPHE-------LSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:COG2274  563 GTIRENITLGdPDAT------DEEIIEAARLAGLhdfiEALPMGYDTVvgeggsnLSGGQRQRLAIARALLRNPRILILD 636

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446273968 163 EPLSALDAILREEMRLELMDIVHsiGLTALYVTHDqTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG2274  637 EATSALDAETEAIILENLRRLLK--GRTVIIIAHR-LSTIRLADRIIVLDKGRIVEDGTHEEL 696

ectoine_ehuA

TIGR03005

ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Members of this family are the ...

3-240

2.25e-43

ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Members of this family are the ATP-binding protein of a conserved four gene ABC transporter operon found next to ectoine unilization operons and ectoine biosynthesis operons. Ectoine is a compatible solute that protects enzymes from high osmolarity. It is released by some species in response to hypoosmotic shock, and it is taken up by a number of bacteria as a compatible solute or for consumption. This family shows strong sequence similiarity to a number of amino acid ABC transporter ATP-binding proteins.

Pssm-ID: 132050 [Multi-domain] Cd Length: 252 Bit Score: 149.59 E-value: 2.25e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTSP---- 77
Cdd:TIGR03005   1 VRFSDVTKRFGILTVLDGLNFSVAAGEKVALIGPSGSGKSTILRILMTLEPIDEGQIQVeGEQLYHMPGRNGPLVPadek 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   78 HER----NIGMVFQDFALWPHMNVFENVAFGLRATK--QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARA 151
Cdd:TIGR03005  81 HLRqmrnKIGMVFQSFNLFPHKTVLDNVTEAPVLVLgmARAEAEKRAMELLDMVGLADKADHMPAQLSGGQQQRVAIARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  152 IVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSH 231
Cdd:TIGR03005 161 LAMRPKVMLFDEVTSALDPELVGEVLNVIRRLASEHDLTMLLVTHEMGFAREFADRVCFFDKGRIVEQGKPDEIFRQPKE 240


                  ....*....
gi 446273968  232 EFVAKFVGK 240
Cdd:TIGR03005 241 ERTREFLSK 249

ABC_subfamily_A

cd03263

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily ...

3-222

2.08e-42

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.

Pssm-ID: 213230 [Multi-domain] Cd Length: 220 Bit Score: 146.11 E-value: 2.08e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQ--ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtspheR 80
Cdd:cd03263    1 LQIRNLTKTYKKGTkpAVDDLSLNVYKGEIFGLLGHNGAGKTTTLKMLTGELRPTSGTAYINGYSIRTDRKAAR-----Q 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFENVAF-----GLRATkqtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:cd03263   76 SLGYCPQFDALFDELTVREHLRFyarlkGLPKS----EIKEEVELLLRVLGLTDKANKRARTLSGGMKRKLSLAIALIGG 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 156 PHFILFDEPLSALDAILREEMrlelMDIVHSI--GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTP 222
Cdd:cd03263  152 PSVLLLDEPTSGLDPASRRAI----WDLILEVrkGRSIILTTHSMDEAEALCDRIAIMSDGKLRCIGSP 216

PRK11831

phospholipid ABC transporter ATP-binding protein MlaF;

3-225

7.96e-42

phospholipid ABC transporter ATP-binding protein MlaF;

Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 146.06 E-value: 7.96e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTSphERN 81
Cdd:PRK11831   8 VDMRGVSFTRGNRCIFDNISLTVPRGKITAIMGPSGIGKTTLLRLIGGQIAPDHGEILFdGENIPAMSRSRLYTV--RKR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATKQTNQ--LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:PRK11831  86 MSMLFQSGALFTDMNVFDNVAYPLREHTQLPAplLHSTVMMKLEAVGLRGAAKLMPSELSGGMARRAALARAIALEPDLI 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 160 LFDEPLSALDAILREEMrLELMD-IVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK11831 166 MFDEPFVGQDPITMGVL-VKLISeLNSALGVTCVVVSHDVPEVLSIADHAYIVADKKIVAHGSAQAL 231

MdlB

COG1132

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];

13-224

3.41e-41

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];

Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 151.09 E-value: 3.41e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakKIKTSPHE---RNIGMVFQDF 89
Cdd:COG1132  351 GDRPVLKDISLTIPPGETVALVGPSGSGKSTLVNLLLRFYDPTSGRILIDGV-------DIRDLTLEslrRQIGVVPQDT 423

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALWpHMNVFENVAFG-LRATkqtnqlREKVEDAIKRVRL----QGMEKRYPHE-------LSGGQQQRVAFARAIVTKPH 157
Cdd:COG1132  424 FLF-SGTIRENIRYGrPDAT------DEEVEEAAKAAQAhefiEALPDGYDTVvgergvnLSGGQRQRIAIARALLKDPP 496

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 158 FILFDEPLSALD----AILREEMRlELMDivhsiGLTALYVTHdqteamSMS-----DQIIVMKQGEVLQKGTPED 224
Cdd:COG1132  497 ILILDEATSALDteteALIQEALE-RLMK-----GRTTIVIAH------RLStirnaDRILVLDDGRIVEQGTHEE 560

cbiO

PRK13635

energy-coupling factor ABC transporter ATP-binding protein;

14-226

1.97e-40

energy-coupling factor ABC transporter ATP-binding protein;

Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 142.85 E-value: 1.97e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssakkIKTSPH-----ERNIGMVFQD 88
Cdd:PRK13635  19 ATYALKDVSFSVYEGEWVAIVGHNGSGKSTLAKLLNGLLLPEAGTITVGG---------MVLSEEtvwdvRRQVGMVFQN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  89 falwPHmNVF------ENVAFGLRatkqtNQ------LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:PRK13635  90 ----PD-NQFvgatvqDDVAFGLE-----NIgvpreeMVERVDQALRQVGMEDFLNREPHRLSGGQKQRVAIAGVLALQP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 157 HFILFDEPLSALDAILREEMrlelMDIVHSI----GLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13635 160 DIIILDEATSMLDPRGRREV----LETVRQLkeqkGITVLSITHDLDEAAQ-ADRVIVMNKGEILEEGTPEEIF 228

CeuD

COG4604

ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and ...

3-225

7.67e-40

ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443654 [Multi-domain] Cd Length: 252 Bit Score: 140.60 E-value: 7.67e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHE--- 79
Cdd:COG4604    2 IEIKNVSKRYGGKVVLDDVSLTIPKGGITALIGPNGAGKSTLLSMISRLLPPDSGEVLVDG-------LDVATTPSRela 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDfalwPHMN----VFENVAFGL------RATKQTnqlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFA 149
Cdd:COG4604   75 KRLAILRQE----NHINsrltVRELVAFGRfpyskgRLTAED---REIIDEAIAYLDLEDLADRYLDELSGGQRQRAFIA 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 150 RAIVTKPHFILFDEPLSALD---AilREEMRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4604  148 MVLAQDTDYVLLDEPLNNLDmkhS--VQMMKL-LRRLADELGKTVVIVLHDINFASCYADHIVAMKDGRVVAQGTPEEI 223

ABC_ATP_DarD

NF038007

darobactin export ABC transporter ATP-binding protein;

14-214

1.10e-39

darobactin export ABC transporter ATP-binding protein;

Pssm-ID: 411600 [Multi-domain] Cd Length: 218 Bit Score: 139.08 E-value: 1.10e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIktSPHERNIGMVFQDFAL 91
Cdd:NF038007  17 KTKVLNHLNFSVEKGDFVSIMGPSGSGKSTLLNIIGMFDSLDSGSLTLAgkEVTNLSYSQKI--ILRRELIGYIFQSFNL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 WPHMNVFENVAFGL--RATKQTNQLrEKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:NF038007  95 IPHLSIFDNVALPLkyRGVAKKERI-ERVNQVLNLFGIDNRRNHKPMQLSGGQQQRVAIARAMVSNPALLLADEPTGNLD 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446273968 170 AILREEMrLELMDIVHSIGLTALYVTHDQtEAMSMSDQIIVMKQG 214
Cdd:NF038007 174 SKNARAV-LQQLKYINQKGTTIIMVTHSD-EASTYGNRIINMKDG 216

PRK10619

histidine ABC transporter ATP-binding protein HisP;

3-241

1.19e-39

histidine ABC transporter ATP-binding protein HisP;

Pssm-ID: 182592 [Multi-domain] Cd Length: 257 Bit Score: 140.10 E-value: 1.19e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGD---TCMYSSAKKIKTSPHE 79
Cdd:PRK10619   6 LNVIDLHKRYGEHEVLKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGqtiNLVRDKDGQLKVADKN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 R------NIGMVFQDFALWPHMNVFENVafgLRATKQTNQL--REKVEDAIKRVRLQGMEKR----YPHELSGGQQQRVA 147
Cdd:PRK10619  86 QlrllrtRLTMVFQHFNLWSHMTVLENV---MEAPIQVLGLskQEARERAVKYLAKVGIDERaqgkYPVHLSGGQQQRVS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYV 227
Cdd:PRK10619 163 IARALAMEPEVLLFDEPTSALDPELVGEV-LRIMQQLAEEGKTMVVVTHEMGFARHVSSHVIFLHQGKIEEEGAPEQLFG 241

                        250
                 ....*....|....
gi 446273968 228 KPSHEFVAKFVGKA 241
Cdd:PRK10619 242 NPQSPRLQQFLKGS 255

ABCC_MRP_Like

cd03228

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ...

13-215

2.34e-39

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 136.74 E-value: 2.34e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALW 92
Cdd:cd03228   13 RPKPVLKDVSLTIKPGEKVAIVGPSGSGKSTLLKLLLRLYDPTSGEILIDGV----DLRDLDLESLRKNIAYVPQDPFLF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 pHMNVFENVafglratkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSALDAIL 172
Cdd:cd03228   89 -SGTIRENI------------------------------------LSGGQRQRIAIARALLRDPPILILDEATSALDPET 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446273968 173 REEMRLELMDIvhSIGLTALYVTHDqTEAMSMSDQIIVMKQGE 215
Cdd:cd03228  132 EALILEALRAL--AKGKTVIVIAHR-LSTIRDADRIIVLDDGR 171

YbbA

COG4181

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ...

3-218

2.67e-39

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443338 [Multi-domain] Cd Length: 233 Bit Score: 138.34 E-value: 2.67e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkikTSPH 78
Cdd:COG4181    9 IELRGLTKTVgtgaGELTILKGISLEVEAGESVAIVGASGSGKSTLLGLLAGLDRPTSGTVRLAGQDL--------FALD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 E--------RNIGMVFQDFALWPHMNVFENVA-----FGLRatkqtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQR 145
Cdd:COG4181   81 EdararlraRHVGFVFQSFQLLPTLTALENVMlplelAGRR------DARARARALLERVGLGHRLDHYPAQLSGGEQQR 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 146 VAFARAIVTKPHfILF-DEPLSALDAILREEMrLELM-DIVHSIGLTALYVTHDQTEAmSMSDQIIVMKQGEVLQ 218
Cdd:COG4181  155 VALARAFATEPA-ILFaDEPTGNLDAATGEQI-IDLLfELNRERGTTLVLVTHDPALA-ARCDRVLRLRAGRLVE 226

ABC_drug_resistance_like

cd03264

ABC-type multidrug transport system, ATPase component; The biological function of this family ...

3-220

1.43e-38

ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213231 [Multi-domain] Cd Length: 211 Bit Score: 135.78 E-value: 1.43e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGeFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmySSAKKIKTSPHERnI 82
Cdd:cd03264    1 LQLENLTKRYGKKRALDGVSLTLGPG-MYGLLGPNGAGKTTLMRILATLTPPSSGTIRIDG----QDVLKQPQKLRRR-I 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAF-----GLRATKQtnqlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:cd03264   75 GYLPQEFGVYPNFTVREFLDYiawlkGIPSKEV----KARVDEVLELVNLGDRAKKKIGSLSGGMRRRVGIAQALVGDPS 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 158 FILFDEPLSALDAilreEMRLELMDIVHSIGLTALYV--THDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03264  151 ILIVDEPTAGLDP----EERIRFRNLLSELGEDRIVIlsTHIVEDVESLCNQVAVLNKGKLVFEG 211

PRK10908

cell division ATP-binding protein FtsE;

12-214

1.50e-38

cell division ATP-binding protein FtsE;

Pssm-ID: 182829 [Multi-domain] Cd Length: 222 Bit Score: 136.16 E-value: 1.50e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMySSAKKIKTSPHERNIGMVFQDFAL 91
Cdd:PRK10908  12 LGGRQALQGVTFHMRPGEMAFLTGHSGAGKSTLLKLICGIERPSAGKIWFSGHDI-TRLKNREVPFLRRQIGMIFQDHHL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 WPHMNVFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:PRK10908  91 LMDRTVYDNVAIPLIiAGASGDDIRRRVSAALDKVGLLDKAKNFPIQLSGGEQQRVGIARAVVNKPAVLLADEPTGNLDD 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446273968 171 ILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:PRK10908 171 ALSEGI-LRLFEEFNRVGVTVLMATHDIGLISRRSYRMLTLSDG 213

PRK14239

phosphate transporter ATP-binding protein; Provisional

3-232

3.49e-38

phosphate transporter ATP-binding protein; Provisional

Pssm-ID: 184585 [Multi-domain] Cd Length: 252 Bit Score: 136.06 E-value: 3.49e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEE--PD---KGEIYFGDTCMYSsaKKIKTSP 77
Cdd:PRK14239   6 LQVSDLSVYYNKKKALNSVSLDFYPNEITALIGPSGSGKSTLLRSINRMNDlnPEvtiTGSIVYNGHNIYS--PRTDTVD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HERNIGMVFQDFALWPhMNVFENVAFGLR--ATKQTNQLREKVEDAIKRVRLQGMEKRYPHE----LSGGQQQRVAFARA 151
Cdd:PRK14239  84 LRKEIGMVFQQPNPFP-MSIYENVVYGLRlkGIKDKQVLDEAVEKSLKGASIWDEVKDRLHDsalgLSGGQQQRVCIARV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IVTKPHFILFDEPLSALDAILR---EEMRLELMDivhsiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:PRK14239 163 LATSPKIILLDEPTSALDPISAgkiEETLLGLKD-----DYTMLLVTRSMQQASRISDRTGFFLDGDLIEYNDTKQMFMN 237


                 ....
gi 446273968 229 PSHE 232
Cdd:PRK14239 238 PKHK 241

CydD

COG4988

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ...

13-224

4.02e-38

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 142.20 E-value: 4.02e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakKIKTSPHE---RNIGMVFQDf 89
Cdd:COG4988  348 GGRPALDGLSLTIPPGERVALVGPSGAGKSTLLNLLLGFLPPYSGSILINGV-------DLSDLDPAswrRQIAWVPQN- 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALWPHMNVFENVAFGLR-ATkqtnqlREKVEDAIKRVRLQGMEKRYPH-------E----LSGGQQQRVAFARAIVTKPH 157
Cdd:COG4988  420 PYLFAGTIRENLRLGRPdAS------DEELEAALEAAGLDEFVAALPDgldtplgEggrgLSGGQAQRLALARALLRDAP 493

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 158 FILFDEPLSALDAilreEMRLELMDIVHSI--GLTALYVTHDqTEAMSMSDQIIVMKQGEVLQKGTPED 224
Cdd:COG4988  494 LLLLDEPTAHLDA----ETEAEILQALRRLakGRTVILITHR-LALLAQADRILVLDDGRIVEQGTHEE 557

ABC_Metallic_Cations

cd03235

ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...

12-214

1.71e-37

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.

Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 133.04 E-value: 1.71e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIY-FGdtcmyssaKKIKTSPHErnIGMVFQDF- 89
Cdd:cd03235    9 YGGHPVLEDVSFEVKPGEFLAIVGPNGAGKSTLLKAILGLLKPTSGSIRvFG--------KPLEKERKR--IGYVPQRRs 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALW--PhMNVFENVAFGLRAT-----KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:cd03235   79 IDRdfP-ISVRDVVLMGLYGHkglfrRLSKADKAKVDEALERVGLSELADRQIGELSGGQQQRVLLARALVQDPDLLLLD 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446273968 163 EPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:cd03235  158 EPFAGVDPKTQEDI-YELLRELRREGMTILVVTHDLGLVLEYFDRVLLLNRT 208

ABC_NatA_sodium_exporter

cd03266

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ...

3-220

3.93e-37

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein.

Pssm-ID: 213233 [Multi-domain] Cd Length: 218 Bit Score: 132.49 E-value: 3.93e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGK----TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKTSPH 78
Cdd:cd03266    2 ITADALTKRFRDvkktVQAVDGVSFTVKPGEVTGLLGPNGAGKTTTLRMLAGLLEPDAGFATV-------DGFDVVKEPA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 E--RNIGMVFQDFALWPHMNVFENVAF--GLRATKQTnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVT 154
Cdd:cd03266   75 EarRRLGFVSDSTGLYDRLTARENLEYfaGLYGLKGD-ELTARLEELADRLGMEELLDRRVGGFSTGMRQKVAIARALVH 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 155 KPHFILFDEPLSALD----AILREEMRlELMDivhsIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03266  154 DPPVLLLDEPTTGLDvmatRALREFIR-QLRA----LGKCILFSTHIMQEVERLCDRVVVLHRGRVVYEG 218

cbiO

PRK13647

cobalt transporter ATP-binding subunit; Provisional

15-223

4.07e-37

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 134.09 E-value: 4.07e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIY-FGDTCMYSSAKKIKTspherNIGMVFQD----- 88
Cdd:PRK13647  18 TKALKGLSLSIPEGSKTALLGPNGAGKSTLLLHLNGIYLPQRGRVKvMGREVNAENEKWVRS-----KVGLVFQDpddqv 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  89 FAlwphMNVFENVAFG---LRATKQtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13647  93 FS----STVWDDVAFGpvnMGLDKD--EVERRVEEALKAVRMWDFRDKPPYHLSYGQKKRVAIAGVLAMDPDVIVLDEPM 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 166 SALDAILREEMRlELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPE 223
Cdd:PRK13647 167 AYLDPRGQETLM-EILDRLHNQGKTVIVATHDVDLAAEWADQVIVLKEGRVLAEGDKS 223

ABC_cobalt_CbiO_domain2

cd03226

Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of ...

13-216

1.19e-36

Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The CbiMNQO family ABC transport system is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

Pssm-ID: 213193 [Multi-domain] Cd Length: 205 Bit Score: 130.84 E-value: 1.19e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHERNIGMVFQDfalw 92
Cdd:cd03226   11 KGTEILDDLSLDLYAGEIIALTGKNGAGKTTLAKILAGLIKESSGSILLNG-------KPIKAKERRKSIGYVMQD---- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 phMN-------VFENVAFGLRATKQTNqlrEKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:cd03226   80 --VDyqlftdsVREELLLGLKELDAGN---EQAETVLKDLDLYALKERHPLSLSGGQKQRLAIAAALLSGKDLLIFDEPT 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446273968 166 SALDailREEMRL--ELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03226  155 SGLD---YKNMERvgELIRELAAQGKAVIVITHDYEFLAKVCDRVLLLANGAI 204

cbiO

PRK13650

energy-coupling factor transporter ATPase;

26-230

1.38e-36

energy-coupling factor transporter ATPase;

Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 132.93 E-value: 1.38e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKtspheRNIGMVFQDfalwPH-----MNVFE 99
Cdd:PRK13650  31 KQGEWLSIIGHNGSGKSTTVRLIDGLLEAESGQIIIdGDLLTEENVWDIR-----HKIGMVFQN----PDnqfvgATVED 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 100 NVAFGLRATKQTNQ-LREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilreEMRL 178
Cdd:PRK13650 102 DVAFGLENKGIPHEeMKERVNEALELVGMQDFKEREPARLSGGQKQRVAIAGAVAMRPKIIILDEATSMLDP----EGRL 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 179 ELMDIVHSI----GLTALYVTHDQTEaMSMSDQIIVMKQGEVLQKGTPEDIYVKPS 230
Cdd:PRK13650 178 ELIKTIKGIrddyQMTVISITHDLDE-VALSDRVLVMKNGQVESTSTPRELFSRGN 232

PRK15079

oligopeptide ABC transporter ATP-binding protein OppF; Provisional

12-231

1.55e-36

oligopeptide ABC transporter ATP-binding protein OppF; Provisional

Pssm-ID: 185037 [Multi-domain] Cd Length: 331 Bit Score: 134.06 E-value: 1.55e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIV---MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEI-YFGDTCMYSSAKKIKTSphERNIGMVFQ 87
Cdd:PRK15079  28 WQPPKTLKAVDGVtlrLYEGETLGVVGESGCGKSTFARAIIGLVKATDGEVaWLGKDLLGMKDDEWRAV--RSDIQMIFQ 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  88 D--FALWPHMNVFENVAFGLRA-----TKQtnQLREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:PRK15079 106 DplASLNPRMTIGEIIAEPLRTyhpklSRQ--EVKDRVKAMMLKVGLlPNLINRYPHEFSGGQCQRIGIARALILEPKLI 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 160 LFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSH 231
Cdd:PRK15079 184 ICDEPVSALDVSIQAQVVNLLQQLQREMGLSLIFIAHDLAVVKHISDRVLVMYLGHAVELGTYDEVYHNPLH 255

ABC_Carb_Monos_I

cd03216

First domain of the ATP-binding cassette component of monosaccharide transport system; This ...

3-216

2.42e-36

First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.

Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 128.70 E-value: 2.42e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIK-TSPHERN 81
Cdd:cd03216    1 LELRGITKRFGGVKALDGVSLSVRRGEVHALLGENGAGKSTLMKILSGLYKPDSGEILVDG-------KEVSfASPRDAR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 ---IGMVFQdfalwphmnvfenvafglratkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHF 158
Cdd:cd03216   74 ragIAMVYQ--------------------------------------------------LSVGERQMVEIARALARNARL 103

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 159 ILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03216  104 LILDEPTAALTPAEVERL-FKVIRRLRAQGVAVIFISHRLDEVFEIADRVTVLRDGRV 160

PRK14247

phosphate ABC transporter ATP-binding protein; Provisional

3-238

3.35e-36

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172735 [Multi-domain] Cd Length: 250 Bit Score: 130.80 E-value: 3.35e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEE--PD---KGEIYFGDTCMYssakKIKTSP 77
Cdd:PRK14247   4 IEIRDLKVSFGQVEVLDGVNLEIPDNTITALMGPSGSGKSTLLRVFNRLIElyPEarvSGEVYLDGQDIF----KMDVIE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HERNIGMVFQDFALWPHMNVFENVAFGL---RATKQTNQLREKVEDAIKRVRL-QGMEKRY---PHELSGGQQQRVAFAR 150
Cdd:PRK14247  80 LRRRVQMVFQIPNPIPNLSIFENVALGLklnRLVKSKKELQERVRWALEKAQLwDEVKDRLdapAGKLSGGQQQRLCIAR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 151 AIVTKPHFILFDEPLSALDAILR---EEMRLELMDivhsiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYV 227
Cdd:PRK14247 160 ALAFQPEVLLADEPTANLDPENTakiESLFLELKK-----DMTIVLVTHFPQQAARISDYVAFLYKGQIVEWGPTREVFT 234

                        250
                 ....*....|.
gi 446273968 228 KPSHEFVAKFV 238
Cdd:PRK14247 235 NPRHELTEKYV 245

ABC_YhbG

cd03218

ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the ...

3-229

3.44e-36

ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.

Pssm-ID: 213185 [Multi-domain] Cd Length: 232 Bit Score: 130.36 E-value: 3.44e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakKIKTSP-HER- 80
Cdd:cd03218    1 LRAENLSKRYGKRKVVNGVSLSVKQGEIVGLLGPNGAGKTTTFYMIVGLVKPDSGKILLDGQ-------DITKLPmHKRa 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 --NIGMVFQDFALWPHMNVFENVAFGLRATKQTN-QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:cd03218   74 rlGIGYLPQEASIFRKLTVEENILAVLEIRGLSKkEREEKLEELLEEFHITHLRKSKASSLSGGERRRVEIARALATNPK 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 158 FILFDEPLSALDAILREEMRlELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:cd03218  154 FLLLDEPFAGVDPIAVQDIQ-KIIKILKDRGIGVLITDHNVRETLSITDRAYIIYEGKVLAEGTPEEIAANE 224

CydC

COG4987

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease ...

13-224

9.20e-36

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444011 [Multi-domain] Cd Length: 569 Bit Score: 136.05 E-value: 9.20e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakKIKTSPHE---RNIGMVFQDF 89
Cdd:COG4987  346 AGRPVLDGLSLTLPPGERVAIVGPSGSGKSTLLALLLRFLDPQSGSITLGGV-------DLRDLDEDdlrRRIAVVPQRP 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALWpHMNVFENVAFGL-RATkqtnqlREKVEDAIKRVRLQGMEKRYPH-------E----LSGGQQQRVAFARAIVTKPH 157
Cdd:COG4987  419 HLF-DTTLRENLRLARpDAT------DEELWAALERVGLGDWLAALPDgldtwlgEggrrLSGGERRRLALARALLRDAP 491

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 158 FILFDEPLSALDAILREEMRLELMDivHSIGLTALYVTHDQTEAMSMsDQIIVMKQGEVLQKGTPED 224
Cdd:COG4987  492 ILLLDEPTEGLDAATEQALLADLLE--ALAGRTVLLITHRLAGLERM-DRILVLEDGRIVEQGTHEE 555

MglA

COG1129

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

3-216

1.73e-35

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 134.38 E-value: 1.73e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIK-TSPHE-- 79
Cdd:COG1129    5 LEMRGISKSFGGVKALDGVSLELRPGEVHALLGENGAGKSTLMKILSGVYQPDSGEILLDG-------EPVRfRSPRDaq 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 -RNIGMVFQDFALWPHMNVFENVAFGLRATK----QTNQLREKVEDAIKRVrlqGMEKRyPH----ELSGGQQQRVAFAR 150
Cdd:COG1129   78 aAGIAIIHQELNLVPNLSVAENIFLGREPRRggliDWRAMRRRARELLARL---GLDID-PDtpvgDLSVAQQQLVEIAR 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 151 AIVTKPHFILFDEPLSALDAilRE-EMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG1129  154 ALSRDARVLILDEPTASLTE--REvERLFRIIRRLKAQGVAIIYISHRLDEVFEIADRVTVLRDGRL 218

ModF

COG1119

ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ...

12-225

2.31e-35

ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism];

Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 128.66 E-value: 2.31e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKG-EIY-FGDtcmyssaKKIKTSPHE--RNIGMVFQ 87
Cdd:COG1119   13 RGGKTILDDISWTVKPGEHWAILGPNGAGKSTLLSLITGDLPPTYGnDVRlFGE-------RRGGEDVWElrKRIGLVSP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  88 DFALW--PHMNVFENVAFGLRAT-----KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:COG1119   86 ALQLRfpRDETVLDVVLSGFFDSiglyrEPTDEQRERARELLELLGLAHLADRPFGTLSQGEQRRVLIARALVKDPELLI 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 161 FDEPLSALDAILREEMrLELMDIVHSIGLTAL-YVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG1119  166 LDEPTAGLDLGARELL-LALLDKLAAEGAPTLvLVTHHVEEIPPGITHVLLLKDGRVVAAGPKEEV 230

cbiO

PRK13632

cobalt transporter ATP-binding subunit; Provisional

14-225

2.33e-35

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 129.34 E-value: 2.33e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIY-FGDTCMYSSAKKIKTspherNIGMVFQDfalw 92
Cdd:PRK13632  21 ENNALKNVSFEINEGEYVAILGHNGSGKSTISKILTGLLKPQSGEIKiDGITISKENLKEIRK-----KIGIIFQN---- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHmNVF------ENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13632  92 PD-NQFigatveDDIAFGLENKKVPpKKMKDIIDDLAKKVGMEDYLDKEPQNLSGGQKQRVAIASVLALNPEIIIFDEST 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 166 SALDAILREEMrLELMDIVHSIGL-TALYVTHDQTEAMsMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK13632 171 SMLDPKGKREI-KKIMVDLRKTRKkTLISITHDMDEAI-LADKVIVFSEGKLIAQGKPKEI 229

PRK13633

energy-coupling factor transporter ATPase;

17-226

2.50e-35

energy-coupling factor transporter ATPase;

Pssm-ID: 237453 [Multi-domain] Cd Length: 280 Bit Score: 129.44 E-value: 2.50e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIKtspheRNIGMVFQDfalwPH 94
Cdd:PRK13633  25 ALDDVNLEVKKGEFLVILGRNGSGKSTIAKHMNALLIPSEGKVYVDglDTSDEENLWDIR-----NKAGMVFQN----PD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MN-----VFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSAL 168
Cdd:PRK13633  96 NQivatiVEEDVAFGPENLGiPPEEIRERVDESLKKVGMYEYRRHAPHLLSGGQKQRVAIAGILAMRPECIIFDEPTAML 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 169 DAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13633 176 DPSGRREVVNTIKELNKKYGITIILITHYMEEAVE-ADRIIVMDSGKVVMEGTPKEIF 232

LivF

COG0410

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid ...

4-225

2.88e-35

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid transport and metabolism];

Pssm-ID: 440179 [Multi-domain] Cd Length: 236 Bit Score: 127.79 E-value: 2.88e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHERN-- 81
Cdd:COG0410    5 EVENLHAGYGGIHVLHGVSLEVEEGEIVALLGRNGAGKTTLLKAISGLLPPRSGSIRFDGEDI------TGLPPHRIArl 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 -IGMVFQDFALWPHMNVFENVAFGLRATKQtnqlREKVEDAIKRV-----RLQGMEKRYPHELSGGQQQRVAFARAIVTK 155
Cdd:COG0410   79 gIGYVPEGRRIFPSLTVEENLLLGAYARRD----RAEVRADLERVyelfpRLKERRRQRAGTLSGGEQQMLAIGRALMSR 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446273968 156 PHFILFDEPLSALDAILREEMrlelMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG0410  155 PKLLLLDEPSLGLAPLIVEEI----FEIIRRLnreGVTILLVEQNARFALEIADRAYVLERGRIVLEGTAAEL 223

cbiO

PRK13643

energy-coupling factor transporter ATPase;

15-226

3.57e-35

energy-coupling factor transporter ATPase;

Pssm-ID: 184203 [Multi-domain] Cd Length: 288 Bit Score: 129.47 E-value: 3.57e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQdfalWPH 94
Cdd:PRK13643  19 SRALFDIDLEVKKGSYTALIGHTGSGKSTLLQHLNGLLQPTEGKVTVGDIVVSSTSKQKEIKPVRKKVGVVFQ----FPE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFE-----NVAFGLRATKQTNQLREKVedAIKRVRLQGMEKRY----PHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13643  95 SQLFEetvlkDVAFGPQNFGIPKEKAEKI--AAEKLEMVGLADEFweksPFELSGGQMRRVAIAGILAMEPEVLVLDEPT 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 166 SALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13643 173 AGLDPKARIEM-MQLFESIHQSGQTVVLVTHLMDDVADYADYVYLLEKGHIISCGTPSDVF 232

ABC_DrrA

cd03265

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein ...

3-225

4.58e-35

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213232 [Multi-domain] Cd Length: 220 Bit Score: 127.10 E-value: 4.58e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtspheRNI 82
Cdd:cd03265    1 IEVENLVKKYGDFEAVRGVSFRVRRGEIFGLLGPNGAGKTTTIKMLTTLLKPTSGRATVAGHDVVREPREVR-----RRI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVA-FGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:cd03265   76 GIVFQDLSVDDELTGWENLYiHARLYGVPGAERRERIDELLDFVGLLEAADRLVKTYSGGMRRRLEIARSLVHRPEVLFL 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:cd03265  156 DEPTIGLDPQTRAHVWEYIEKLKEEFGMTILLTTHYMEEAEQLCDRVAIIDHGRIIAEGTPEEL 219

cbiO

PRK13634

cobalt transporter ATP-binding subunit; Provisional

1-229

5.40e-35

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 128.98 E-value: 5.40e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGK-----TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKT 75
Cdd:PRK13634   1 MDITFQKVEHRYQYktpfeRRALYDVNVSIPSGSYVAIIGHTGSGKSTLLQHLNGLLQPTSGTVTIGERVITAGKKNKKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SPHERNIGMVFQdfalWPHMNVFE-----NVAFGlratkQTNqLREKVEDAIKRVR----LQGMEK----RYPHELSGGQ 142
Cdd:PRK13634  81 KPLRKKVGIVFQ----FPEHQLFEetvekDICFG-----PMN-FGVSEEDAKQKARemieLVGLPEellaRSPFELSGGQ 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 143 QQRVAFARAIVTKPHFILFDEPLSALDAILREEMrlelMDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQ 218
Cdd:PRK13634 151 MRRVAIAGVLAMEPEVLVLDEPTAGLDPKGRKEM----MEMFYKLhkekGLTTVLVTHSMEDAARYADQIVVMHKGTVFL 226

                        250
                 ....*....|.
gi 446273968 219 KGTPEDIYVKP 229
Cdd:PRK13634 227 QGTPREIFADP 237

PhnK

COG1101

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

3-226

6.12e-35

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 440718 [Multi-domain] Cd Length: 264 Bit Score: 127.89 E-value: 6.12e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGK-----TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKI-KTS 76
Cdd:COG1101    2 LELKNLSKTFNPgtvneKRALDGLNLTIEEGDFVTVIGSNGAGKSTLLNAIAGSLPPDSGSILIDG-------KDVtKLP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  77 PHER--NIGMVFQDFAL--WPHMNVFENVA--------FGLRATkQTNQLREKVEDAIKRVRLqGMEKRYPHE---LSGG 141
Cdd:COG1101   75 EYKRakYIGRVFQDPMMgtAPSMTIEENLAlayrrgkrRGLRRG-LTKKRRELFRELLATLGL-GLENRLDTKvglLSGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 142 QQQRVAFARAIVTKPHFILFDEPLSALD---AilreEMRLEL-MDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVL 217
Cdd:COG1101  153 QRQALSLLMATLTKPKLLLLDEHTAALDpktA----ALVLELtEKIVEENNLTTLMVTHNMEQALDYGNRLIMMHEGRII 228

                        250
                 ....*....|....*..
gi 446273968 218 --------QKGTPEDIY 226
Cdd:COG1101  229 ldvsgeekKKLTVEDLL 245

cbiO

PRK13636

cobalt transporter ATP-binding subunit; Provisional

15-228

6.63e-35

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184196 [Multi-domain] Cd Length: 283 Bit Score: 128.43 E-value: 6.63e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSphERNIGMVFQD-----F 89
Cdd:PRK13636  19 THALKGININIKKGEVTAILGGNGAGKSTLFQNLNGILKPSSGRILFDGKPIDYSRKGLMKL--RESVGMVFQDpdnqlF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 AlwphMNVFENVAFG-LRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSAL 168
Cdd:PRK13636  97 S----ASVYQDVSFGaVNLKLPEDEVRKRVDNALKRTGIEHLKDKPTHCLSFGQKKRVAIAGVLVMEPKVLVLDEPTAGL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 169 DAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:PRK13636 173 DPMGVSEIMKLLVEMQKELGLTIIIATHDIDIVPLYCDNVFVMKEGRVILQGNPKEVFAE 232

ABC_putative_ATPase

cd03269

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ...

3-220

6.75e-35

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 126.24 E-value: 6.75e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAK-KIKTSPHERn 81
Cdd:cd03269    1 LEVENVTKRFGRVTALDDISFSVEKGEIFGLLGPNGAGKTTTIRMILGIILPDSGEVLFDGKPLDIAARnRIGYLPEER- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 igmvfqdfALWPHMNVFEN-VAFG-LRATKQTnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:cd03269   80 --------GLYPKMKVIDQlVYLAqLKGLKKE-EARRRIDEWLERLELSEYANKRVEELSKGNQQKVQFIAAVIHDPELL 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 160 LFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03269  151 ILDEPFSGLDPVNVELLKDVIRELARA-GKTVILSTHQMELVEELCDRVLLLNKGRAVLYG 210

PRK15134

microcin C ABC transporter ATP-binding protein YejF; Provisional

8-233

7.82e-35

microcin C ABC transporter ATP-binding protein YejF; Provisional

Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 132.91 E-value: 7.82e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   8 LEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTT----LLRMIAGleepdKGEIYFGDTCMYSSAKKiKTSPHERNIG 83
Cdd:PRK15134 292 LKRTVDHNVVVKNISFTLRPGETLGLVGESGSGKSTtglaLLRLINS-----QGEIWFDGQPLHNLNRR-QLLPVRHRIQ 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  84 MVFQD--FALWPHMNVFENVAFGLRATKQT---NQLREKVEDAIKRVRLQGMEK-RYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:PRK15134 366 VVFQDpnSSLNPRLNVLQIIEEGLRVHQPTlsaAQREQQVIAVMEEVGLDPETRhRYPAEFSGGQRQRIAIARALILKPS 445

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 158 FILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PRK15134 446 LIILDEPTSSLDKTVQAQILALLKSLQQKHQLAYLFISHDLHVVRALCHQVIVLRQGEVVEQGDCERVFAAPQQEY 521

nickel_nikD

TIGR02770

nickel import ATP-binding protein NikD; This family represents the NikD subunit of a ...

21-239

7.92e-35

nickel import ATP-binding protein NikD; This family represents the NikD subunit of a multisubunit nickel import ABC transporter complex. Nickel, once imported, may be used in urease and in certain classes of hydrogenase and superoxide dismutase. NikD and NikE are homologous. [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 131817 [Multi-domain] Cd Length: 230 Bit Score: 126.71 E-value: 7.92e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   21 LQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD----KGEIYFGDTCMYSSAKKiktsphERNIGMVFQD--FALWPH 94
Cdd:TIGR02770   5 LNLSLKRGEVLALVGESGSGKSLTCLAILGLLPPGltqtSGEILLDGRPLLPLSIR------GRHIATIMQNprTAFNPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   95 MNVFENVAFGLRA-TKQTNQLREKVEDAIKRVRLQGME---KRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:TIGR02770  79 FTMGNHAIETLRSlGKLSKQARALILEALEAVGLPDPEevlKKYPFQLSGGMLQRVMIALALLLEPPFLIADEPTTDLDV 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968  171 ILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:TIGR02770 159 VNQARVLKLLRELRQLFGTGILLITHDLGVVARIADEVAVMDDGRIVERGTVKEIFYNPKHETTRKLLS 227

cbiO

PRK13639

cobalt transporter ATP-binding subunit; Provisional

15-226

1.33e-34

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184199 [Multi-domain] Cd Length: 275 Bit Score: 127.50 E-value: 1.33e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTsphERNIGMVFQD----- 88
Cdd:PRK13639  15 TEALKGINFKAEKGEMVALLGPNGAGKSTLFLHFNGILKPTSGEVLIkGEPIKYDKKSLLEV---RKTVGIVFQNpddql 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  89 FAlwPhmNVFENVAFG-LRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:PRK13639  92 FA--P--TVEEDVAFGpLNLGLSKEEVEKRVKEALKAVGMEGFENKPPHHLSGGQKKRVAIAGILAMKPEIIVLDEPTSG 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 168 LDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13639 168 LDPMGASQI-MKLLYDLNKEGITIIISTHDVDLVPVYADKVYVMSDGKIIKEGTPKEVF 225

cbiO

PRK13648

cobalt transporter ATP-binding subunit; Provisional

27-226

1.62e-34

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 127.17 E-value: 1.62e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  27 QGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYS-SAKKIKtspheRNIGMVFQDfalwPHmNVF------E 99
Cdd:PRK13648  34 KGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDdNFEKLR-----KHIGIVFQN----PD-NQFvgsivkY 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 100 NVAFGLRA-TKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilreEMRL 178
Cdd:PRK13648 104 DVAFGLENhAVPYDEMHRRVSEALKQVDMLERADYEPNALSGGQKQRVAIAGVLALNPSVIILDEATSMLDP----DARQ 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446273968 179 ELMDIVHSI----GLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13648 180 NLLDLVRKVksehNITIISITHDLSEAME-ADHVIVMNKGTVYKEGTPTEIF 230

ABCC_ATM1_transporter

cd03253

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ...

16-223

2.15e-34

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 125.81 E-value: 2.15e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmySSAKKIKTSPHERNIGMVFQDFALWpHM 95
Cdd:cd03253   15 PVLKDVSFTIPAGKKVAIVGPSGSGKSTILRLLFRFYDVSSGSILIDG----QDIREVTLDSLRRAIGVVPQDTVLF-ND 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFENVAFG-LRATKqtnqlrEKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:cd03253   90 TIGYNIRYGrPDATD------EEVIEAAKAAQIHDKIMRFPDgydtivgerglKLSGGEKQRVAIARAILKNPPILLLDE 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 164 PLSALDAILREEMRLELMDIvhSIGLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPE 223
Cdd:cd03253  164 ATSALDTHTEREIQAALRDV--SKGRTTIVIAHRLSTIVN-ADKIIVLKDGRIVERGTHE 220

PRK14267

phosphate ABC transporter ATP-binding protein; Provisional

3-238

3.84e-34

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 184596 [Multi-domain] Cd Length: 253 Bit Score: 125.72 E-value: 3.84e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD-----KGEIYFGDTCMYSSakkiKTSP 77
Cdd:PRK14267   5 IETVNLRVYYGSNHVIKGVDLKIPQNGVFALMGPSGCGKSTLLRTFNRLLELNeearvEGEVRLFGRNIYSP----DVDP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HE--RNIGMVFQDFALWPHMNVFENVAFGLRAT---KQTNQLREKVEDAIKRVRL----QGMEKRYPHELSGGQQQRVAF 148
Cdd:PRK14267  81 IEvrREVGMVFQYPNPFPHLTIYDNVAIGVKLNglvKSKKELDERVEWALKKAALwdevKDRLNDYPSNLSGGQRQRLVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 149 ARAIVTKPHFILFDEPLSALDAILR---EEMRLELMDivhsiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK14267 161 ARALAMKPKILLMDEPTANIDPVGTakiEELLFELKK-----EYTIVLVTHSPAQAARVSDYVAFLYLGKLIEVGPTRKV 235

                        250
                 ....*....|...
gi 446273968 226 YVKPSHEFVAKFV 238
Cdd:PRK14267 236 FENPEHELTEKYV 248

NupO

COG3845

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ...

3-216

5.87e-34

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 130.15 E-value: 5.87e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIK-TSPHE-- 79
Cdd:COG3845    6 LELRGITKRFGGVVANDDVSLTVRPGEIHALLGENGAGKSTLMKILYGLYQPDSGEILIDG-------KPVRiRSPRDai 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 -RNIGMVFQDFALWPHMNVFENVAFGLRATKQ----TNQLREKVEDAIKRVrlqGME---KRYPHELSGGQQQRVAFARA 151
Cdd:COG3845   79 aLGIGMVHQHFMLVPNLTVAENIVLGLEPTKGgrldRKAARARIRELSERY---GLDvdpDAKVEDLSVGEQQRVEILKA 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 152 IVTKPHFILFDEPLSALDAilrEEMRlELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG3845  156 LYRGARILILDEPTAVLTP---QEAD-ELFEILRRLaaeGKSIIFITHKLREVMAIADRVTVLRRGKV 219

cbiO

PRK13637

energy-coupling factor transporter ATPase;

1-226

8.59e-34

energy-coupling factor transporter ATPase;

Pssm-ID: 237455 [Multi-domain] Cd Length: 287 Bit Score: 125.55 E-value: 8.59e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGL-----EKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSsaKKIKT 75
Cdd:PRK13637   1 MSIKIENLthiymEGTPFEKKALDNVNIEIEDGEFVGLIGHTGSGKSTLIQHLNGLLKPTSGKIIIDGVDITD--KKVKL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SPHERNIGMVFQdfalWPHMNVFE-----NVAFGLRATKQT-NQLREKVEDAIKRVRL--QGMEKRYPHELSGGQQQRVA 147
Cdd:PRK13637  79 SDIRKKVGLVFQ----YPEYQLFEetiekDIAFGPINLGLSeEEIENRVKRAMNIVGLdyEDYKDKSPFELSGGQKRRVA 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13637 155 IAGVVAMEPKILILDEPTAGLDPKGRDEILNKIKELHKEYNMTIILVSHSMEDVAKLADRIIVMNKGKCELQGTPREVF 233

YhaQ

COG4152

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

3-225

2.70e-33

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 443322 [Multi-domain] Cd Length: 298 Bit Score: 124.45 E-value: 2.70e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEI-YFGDTCMYSSAKKIKTSPHERn 81
Cdd:COG4152    2 LELKGLTKRFGDKTAVDDVSFTVPKGEIFGLLGPNGAGKTTTIRIILGILAPDSGEVlWDGEPLDPEDRRRIGYLPEER- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 igmvfqdfALWPHMNVFENVAF-----GLRAtkqtNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:COG4152   81 --------GLYPKMKVGEQLVYlarlkGLSK----AEAKRRADEWLERLGLGDRANKKVEELSKGNQQKVQLIAALLHDP 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 157 HFILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4152  149 ELLILDEPFSGLDPVNVELLKDVIRELAAK-GTTVIFSSHQMELVEELCDRIVIINKGRKVLSGSVDEI 216

LptB

COG1137

ABC-type lipopolysaccharide export system, ATPase component [Cell wall/membrane/envelope ...

1-226

1.33e-32

ABC-type lipopolysaccharide export system, ATPase component [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440752 [Multi-domain] Cd Length: 240 Bit Score: 120.90 E-value: 1.33e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTC-----MYSSAKKikt 75
Cdd:COG1137    2 MTLEAENLVKSYGKRTVVKDVSLEVNQGEIVGLLGPNGAGKTTTFYMIVGLVKPDSGRIFLDGEDithlpMHKRARL--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 spherniGM--------VFQDfalwphMNVFENVAFGLRATKQT-NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRV 146
Cdd:COG1137   79 -------GIgylpqeasIFRK------LTVEDNILAVLELRKLSkKEREERLEELLEEFGITHLRKSKAYSLSGGERRRV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 147 AFARAIVTKPHFILFDEPLSALDAILREEMRlelmDIVHS-----IG-LtalyVT-HDQTEAMSMSDQIIVMKQGEVLQK 219
Cdd:COG1137  146 EIARALATNPKFILLDEPFAGVDPIAVADIQ----KIIRHlkergIGvL----ITdHNVRETLGICDRAYIISEGKVLAE 217


                 ....*..
gi 446273968 220 GTPEDIY 226
Cdd:COG1137  218 GTPEEIL 224

ABC_BcrA_bacitracin_resist

cd03268

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily ...

3-220

2.64e-32

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.

Pssm-ID: 213235 [Multi-domain] Cd Length: 208 Bit Score: 119.24 E-value: 2.64e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmySSAKKIKTSPHERNI 82
Cdd:cd03268    1 LKTNDLTKTYGKKRVLDDISLHVKKGEIYGFLGPNGAGKTTTMKIILGLIKPDSGEITF------DGKSYQKNIEALRRI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATkqtnQLREK-VEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:cd03268   75 GALIEAPGFYPNLTARENLRLLARLL----GIRKKrIDEVLDVVGLKDSAKKKVKGFSLGMKQRLGIALALLGNPDLLIL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03268  151 DEPTNGLDPDGIKELRELILSLRDQ-GITVLISSHLLSEIQKVADRIGIINKGKLIEEG 208

COG4559

ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism];

3-224

6.12e-32

ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443620 [Multi-domain] Cd Length: 258 Bit Score: 119.84 E-value: 6.12e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSsakkikTSPHE--R 80
Cdd:COG4559    2 LEAENLSVRLGGRTLLDDVSLTLRPGELTAIIGPNGAGKSTLLKLLTGELTPSSGEVRLNGRPLAA------WSPWElaR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQD----FALwphmNVFENVAFGL----RATKQTNQLrekVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAI 152
Cdd:COG4559   76 RRAVLPQHsslaFPF----TVEEVVALGRaphgSSAAQDRQI---VREALALVGLAHLAGRSYQTLSGGEQQRVQLARVL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 153 V-------TKPHFILFDEPLSALD--------AILRE--EMRLELMDIVHSIGLTALYvthdqteamsmSDQIIVMKQGE 215
Cdd:COG4559  149 AqlwepvdGGPRWLFLDEPTSALDlahqhavlRLARQlaRRGGGVVAVLHDLNLAAQY-----------ADRILLLHQGR 217


                 ....*....
gi 446273968 216 VLQKGTPED 224
Cdd:COG4559  218 LVAQGTPEE 226

PRK09984

phosphonate ABC transporter ATP-binding protein;

3-223

6.22e-32

phosphonate ABC transporter ATP-binding protein;

Pssm-ID: 182182 [Multi-domain] Cd Length: 262 Bit Score: 120.12 E-value: 6.22e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKG-----EIyFGDTCMYSS--AKKIKT 75
Cdd:PRK09984   5 IRVEKLAKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKSTLLRHLSGLITGDKSagshiEL-LGRTVQREGrlARDIRK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  76 SphERNIGMVFQDFALWPHMNVFENVAFGLRATKQ---------TNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRV 146
Cdd:PRK09984  84 S--RANTGYIFQQFNLVNRLSVLENVLIGALGSTPfwrtcfswfTREQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 147 AFARAIVTKPHFILFDEPLSALDAilrEEMRLeLMDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTP 222
Cdd:PRK09984 162 AIARALMQQAKVILADEPIASLDP---ESARI-VMDTLRDInqndGITVVVTLHQVDYALRYCERIVALRQGHVFYDGSS 237


                 .
gi 446273968 223 E 223
Cdd:PRK09984 238 Q 238

PRK15112

peptide ABC transporter ATP-binding protein SapF;

16-238

8.95e-32

peptide ABC transporter ATP-binding protein SapF;

Pssm-ID: 185067 [Multi-domain] Cd Length: 267 Bit Score: 119.89 E-value: 8.95e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIY-------FGDTCmYSSAKkiktsphernIGMVFQD 88
Cdd:PRK15112  27 EAVKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTSGELLiddhplhFGDYS-YRSQR----------IRMIFQD 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  89 --FALWPHMNVFENVAFGLRA-TKQTNQLREK-VEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:PRK15112  96 psTSLNPRQRISQILDFPLRLnTDLEPEQREKqIIETLRQVGLlPDHASYYPHMLAPGQKQRLGLARALILRPKVIIADE 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 164 PLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:PRK15112 176 ALASLDMSMRSQLINLMLELQEKQGISYIYVTQHLGMMKHISDQVLVMHQGEVVERGSTADVLASPLHELTKRLI 250

lolD

PRK11629

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

15-221

1.07e-31

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 118.76 E-value: 1.07e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWPH 94
Cdd:PRK11629  22 TDVLHNVSFSIGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFENVAFGLR-ATKQTNQLREKVEDAIKRVrlqGMEKRYPH---ELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:PRK11629 102 FTALENVAMPLLiGKKKPAEINSRALEMLAAV---GLEHRANHrpsELSGGERQRVAIARALVNNPRLVLADEPTGNLDA 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446273968 171 ILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQiIVMKQGEVLQKGT 221
Cdd:PRK11629 179 RNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRMSRQ-LEMRDGRLTAELS 228

dppF

PRK11308

dipeptide transporter ATP-binding subunit; Provisional

7-231

1.69e-31

dipeptide transporter ATP-binding subunit; Provisional

Pssm-ID: 236898 [Multi-domain] Cd Length: 327 Bit Score: 120.45 E-value: 1.69e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   7 GLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTSphERNIGMV 85
Cdd:PRK11308  20 GLFKPERLVKALDGVSFTLERGKTLAVVGESGCGKSTLARLLTMIETPTGGELYYqGQDLLKADPEAQKLL--RQKIQIV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDfalwPH--MNVFENVAFGLRATKQTN------QLREKVEDAIKRVRLQGmE--KRYPHELSGGQQQRVAFARAIVTK 155
Cdd:PRK11308  98 FQN----PYgsLNPRKKVGQILEEPLLINtslsaaERREKALAMMAKVGLRP-EhyDRYPHMFSGGQRQRIAIARALMLD 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSH 231
Cdd:PRK11308 173 PDVVVADEPVSALDVSVQAQVLNLMMDLQQELGLSYVFISHDLSVVEHIADEVMVMYLGRCVEKGTKEQIFNNPRH 248

LPS_export_lptB

TIGR04406

LPS export ABC transporter ATP-binding protein; Members of this fmaily are LptB, the ...

3-225

1.93e-31

LPS export ABC transporter ATP-binding protein; Members of this fmaily are LptB, the ATP-binding cassette protein of an ABC transporter involved in lipopolysaccharide export. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]

Pssm-ID: 275199 [Multi-domain] Cd Length: 239 Bit Score: 118.15 E-value: 1.93e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakKIKTSP-HER- 80
Cdd:TIGR04406   2 LVAENLIKSYKKRKVVNDVSLSVKSGEIVGLLGPNGAGKTTSFYMIVGLVRPDAGKILIDGQ-------DITHLPmHERa 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   81 --NIGMVFQDFALWPHMNVFENVAFGLRATKQT--NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:TIGR04406  75 rlGIGYLPQEASIFRKLTVEENIMAVLEIRKDLdrAEREERLEALLEEFQISHLRDNKAMSLSGGERRRVEIARALATNP 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968  157 HFILFDEPLSALDAILREEMRlELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:TIGR04406 155 KFILLDEPFAGVDPIAVGDIK-KIIKHLKERGIGVLITDHNVRETLDICDRAYIISDGKVLAEGTPAEI 222

cbiO

PRK13644

energy-coupling factor transporter ATPase;

15-230

2.33e-31

energy-coupling factor transporter ATPase;

Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 118.94 E-value: 2.33e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIKtspheRNIGMVFQDfalw 92
Cdd:PRK13644  15 TPALENINLVIKKGEYIGIIGKNGSGKSTLALHLNGLLRPQKGKVLVSgiDTGDFSKLQGIR-----KLVGIVFQN---- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHMN-----VFENVAFGLR-ATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:PRK13644  86 PETQfvgrtVEEDLAFGPEnLCLPPIEIRKRVDRALAEIGLEKYRHRSPKTLSGGQGQCVALAGILTMEPECLIFDEVTS 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 167 ALD-----AILREEMRLelmdivHSIGLTALYVTHDqTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPS 230
Cdd:PRK13644 166 MLDpdsgiAVLERIKKL------HEKGKTIVYITHN-LEELHDADRIIVMDRGKIVLEGEPENVLSDVS 227

hmuV

PRK13548

hemin importer ATP-binding subunit; Provisional

3-224

2.94e-31

hemin importer ATP-binding subunit; Provisional

Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 117.95 E-value: 2.94e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIK-TSPHE-- 79
Cdd:PRK13548   3 LEARNLSVRLGGRTLLDDVSLTLRPGEVVAILGPNGAGKSTLLRALSGELSPDSGEVRLNG-------RPLAdWSPAEla 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQ----DFALwphmNVFENVAFGL----RATKQTNQLrekVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARA 151
Cdd:PRK13548  76 RRRAVLPQhsslSFPF----TVEEVVAMGRaphgLSRAEDDAL---VAAALAQVDLAHLAGRDYPQLSGGEQQRVQLARV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IV------TKPHFILFDEPLSALDaiLREEmrLELMDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGT 221
Cdd:PRK13548 149 LAqlwepdGPPRWLLLDEPTSALD--LAHQ--HHVLRLARQLaherGLAVIVVLHDLNLAARYADRIVLLHQGRLVADGT 224


                 ...
gi 446273968 222 PED 224
Cdd:PRK13548 225 PAE 227

PRK14243

phosphate transporter ATP-binding protein; Provisional

12-238

3.50e-31

phosphate transporter ATP-binding protein; Provisional

Pssm-ID: 184588 [Multi-domain] Cd Length: 264 Bit Score: 117.96 E-value: 3.50e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLR-------MIAGLEEpdKGEIYFGDTCMYssAKKIKTSPHERNIGM 84
Cdd:PRK14243  20 YGSFLAVKNVWLDIPKNQITAFIGPSGCGKSTILRcfnrlndLIPGFRV--EGKVTFHGKNLY--APDVDPVEVRRRIGM 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VFQDFALWPHmNVFENVAFGLRATKQTNQLREKVEDAIKRVRL----QGMEKRYPHELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:PRK14243  96 VFQKPNPFPK-SIYDNIAYGARINGYKGDMDELVERSLRQAALwdevKDKLKQSGLSLSGGQQQRLCIARAIAVQPEVIL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 161 FDEPLSALDAI--LREEmrlELMdivHSIG--LTALYVTHDQTEAMSMSDQIIVM---------KQGEVLQKGTPEDIYV 227
Cdd:PRK14243 175 MDEPCSALDPIstLRIE---ELM---HELKeqYTIIIVTHNMQQAARVSDMTAFFnveltegggRYGYLVEFDRTEKIFN 248

                        250
                 ....*....|.
gi 446273968 228 KPSHEFVAKFV 238
Cdd:PRK14243 249 SPQQQATRDYV 259

nikE

PRK10419

nickel ABC transporter ATP-binding protein NikE;

12-218

5.96e-31

nickel ABC transporter ATP-binding protein NikE;

Pssm-ID: 236689 [Multi-domain] Cd Length: 268 Bit Score: 117.48 E-value: 5.96e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIV---MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPH---ERNIGMV 85
Cdd:PRK10419  19 SGKHQHQTVLNNVslsLKSGETVALLGRSGCGKSTLARLLVGLESPSQGNVSWRGE----PLAKLNRAQRkafRRDIQMV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDF--ALWPHMNVFENVAFGLRatkqtNQLREKVEDAIKRVR--LQGME------KRYPHELSGGQQQRVAFARAIVTK 155
Cdd:PRK10419  95 FQDSisAVNPRKTVREIIREPLR-----HLLSLDKAERLARASemLRAVDlddsvlDKRPPQLSGGQLQRVCLARALAVE 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQ 218
Cdd:PRK10419 170 PKLLILDEAVSNLDLVLQAGVIRLLKKLQQQFGTACLFITHDLRLVERFCQRVMVMDNGQIVE 232

YejF

COG4172

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...

13-231

9.32e-31

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 121.33 E-value: 9.32e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKT----TLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHE------RNI 82
Cdd:COG4172   21 GTVEAVKGVSFDIAAGETLALVGESGSGKSvtalSILRLLPDPAAHPSGSILFDGQDL------LGLSERElrrirgNRI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQD--FALWPHMNVFENVA------FGLRATkqtnQLREKVEDAIKRVRLQGMEKR---YPHELSGGQQQRVAFARA 151
Cdd:COG4172   95 AMIFQEpmTSLNPLHTIGKQIAevlrlhRGLSGA----AARARALELLERVGIPDPERRldaYPHQLSGGQRQRVMIAMA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IVTKPHFILFDEPLSALDAILREEMrLELM-DIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPS 230
Cdd:COG4172  171 LANEPDLLIADEPTTALDVTVQAQI-LDLLkDLQRELGMALLLITHDLGVVRRFADRVAVMRQGEIVEQGPTAELFAAPQ 249


                 .
gi 446273968 231 H 231
Cdd:COG4172  250 H 250

met_CoM_red_A2

TIGR03269

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...

3-225

4.30e-30

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis]

Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 119.52 E-value: 4.30e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNF-----GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF--GDTCMyssaKKIKT 75
Cdd:TIGR03269 280 IKVRNVSKRYisvdrGVVKAVDNVSLEVKEGEIFGIVGTSGAGKTTLSKIIAGVLEPTSGEVNVrvGDEWV----DMTKP 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   76 SPHERN-----IGMVFQDFALWPHMNVFENV--AFGLRATKQTNQLRekvedAIKRVRLQGMEK--------RYPHELSG 140
Cdd:TIGR03269 356 GPDGRGrakryIGILHQEYDLYPHRTVLDNLteAIGLELPDELARMK-----AVITLKMVGFDEekaeeildKYPDELSE 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  141 GQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:TIGR03269 431 GERHRVALAQVLIKEPRIVILDEPTGTMDPITKVDVTHSILKAREEMEQTFIIVSHDMDFVLDVCDRAALMRDGKIVKIG 510


                  ....*
gi 446273968  221 TPEDI 225
Cdd:TIGR03269 511 DPEEI 515

ABCG_EPDR

cd03213

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ...

13-220

5.56e-30

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.

Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 113.03 E-value: 5.56e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGL--EEPDKGEIYFGDTCMYSSAKKiktspheRNIGMVFQDFA 90
Cdd:cd03213   20 SGKQLLKNVSGKAKPGELTAIMGPSGAGKSTLLNALAGRrtGLGVSGEVLINGRPLDKRSFR-------KIIGYVPQDDI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LWPHMNVFENVAFGlratkqtnqlrekvedaikrVRLQGmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:cd03213   93 LHPTLTVRETLMFA--------------------AKLRG--------LSGGERKRVSIALELVSNPSLLFLDEPTSGLDS 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446273968 171 IlreeMRLELMDIVHSI---GLTALYVTHD-QTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03213  145 S----SALQVMSLLRRLadtGRTIICSIHQpSSEIFELFDKLLLLSQGRVIYFG 194

cbiO

PRK13640

energy-coupling factor transporter ATPase;

14-230

9.29e-30

energy-coupling factor transporter ATPase;

Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 114.90 E-value: 9.29e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGE--------IYFGDTCMYSSAKKIktspherniGMV 85
Cdd:PRK13640  19 KKPALNDISFSIPRGSWTALIGHNGSGKSTISKLINGLLLPDDNPnskitvdgITLTAKTVWDIREKV---------GIV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDfalwPH-----MNVFENVAFGL--RATKQtNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:PRK13640  90 FQN----PDnqfvgATVGDDVAFGLenRAVPR-PEMIKIVRDVLADVGMLDYIDSEPANLSGGQKQRVAIAGILAVEPKI 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 159 ILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAmSMSDQIIVMKQGEVLQKGTPEDIYVKPS 230
Cdd:PRK13640 165 IILDESTSMLDPAGKEQILKLIRKLKKKNNLTVISITHDIDEA-NMADQVLVLDDGKLLAQGSPVEIFSKVE 235

ABCC_Glucan_exporter_like

cd03254

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ...

13-228

1.19e-29

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 113.09 E-value: 1.19e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALW 92
Cdd:cd03254   14 EKKPVLKDINFSIKPGETVAIVGPTGAGKTTLINLLMRFYDPQKGQILIDGI----DIRDISRKSLRSMIGVVLQDTFLF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHmNVFENVAFGlratKQTNQlREKVEDAIKRVRLQGMEKRYP-----------HELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:cd03254   90 SG-TIMENIRLG----RPNAT-DEEVIEAAKEAGAHDFIMKLPngydtvlgengGNLSQGERQLLAIARAMLRDPKILIL 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 162 DEPLSALD----AILREEMRlELMDivhsiGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:cd03254  164 DEATSNIDteteKLIQEALE-KLMK-----GRTSIIIAH-RLSTIKNADKILVLDDGKIIEEGTHDELLAK 227

CydD

TIGR02857

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ...

3-211

1.65e-29

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD

Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 118.16 E-value: 1.65e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNF-GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERN 81
Cdd:TIGR02857 322 LEFSGVSVAYpGRRPALRPVSFTVPPGERVALVGPSGAGKSTLLNLLLGFVDPTEGSIAVNGV----PLADADADSWRDQ 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   82 IGMVFQDfalwPHM---NVFENVAFGLRATKqtnqlREKVEDAIKRVRLQGMEKRYP-----------HELSGGQQQRVA 147
Cdd:TIGR02857 398 IAWVPQH----PFLfagTIAENIRLARPDAS-----DAEIREALERAGLDEFVAALPqgldtpigeggAGLSGGQAQRLA 468

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968  148 FARAIVTKPHFILFDEPLSALD----AILREEMRlELMDivhsiGLTALYVTHDqTEAMSMSDQIIVM 211
Cdd:TIGR02857 469 LARAFLRDAPLLLLDEPTAHLDaeteAEVLEALR-ALAQ-----GRTVLLVTHR-LALAALADRIVVL 529

fecE

PRK11231

Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;

1-225

3.53e-29

Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;

Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 112.41 E-value: 3.53e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYS-SAKKIKtsphe 79
Cdd:PRK11231   1 MTLRTENLTVGYGTKRILNDLSLSLPTGKITALIGPNGCGKSTLLKCFARLLTPQSGTVFLGDKPISMlSSRQLA----- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDFALWPHMNVFENVAFGlRAT------KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIV 153
Cdd:PRK11231  76 RRLALLPQHHLTPEGITVRELVAYG-RSPwlslwgRLSAEDNARVNQAMEQTRINHLADRRLTDLSGGQRQRAFLAMVLA 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 154 TKPHFILFDEPLSALDaILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK11231 155 QDTPVVLLDEPTTYLD-INHQVELMRLMRELNTQGKTVVTVLHDLNQASRYCDHLVVLANGHVMAQGTPEEV 225

ABCC_MsbA

cd03251

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ...

17-226

4.15e-29

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 111.55 E-value: 4.15e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALWpHMN 96
Cdd:cd03251   17 VLRDISLDIPAGETVALVGPSGSGKSTLVNLIPRFYDVDSGRILIDGH----DVRDYTLASLRRQIGLVSQDVFLF-NDT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 VFENVAFGLRatkqtNQLREKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:cd03251   92 VAENIAYGRP-----GATREEVEEAARAANAHEFIMELPEgydtvigergvKLSGGQRQRIAIARALLKDPPILILDEAT 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 166 SALDaiLREEMRL-----ELMDivhsiGLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:cd03251  167 SALD--TESERLVqaaleRLMK-----NRTTFVIAHRLSTIEN-ADRIVVLEDGKIVERGTHEELL 224

NHLM_micro_ABC2

TIGR03797

NHLM bacteriocin system ABC transporter, ATP-binding protein; Members of this protein family ...

16-224

9.93e-29

NHLM bacteriocin system ABC transporter, ATP-binding protein; Members of this protein family are ABC transporter ATP-binding subunits, part of a three-gene putative bacteriocin transport operon. The other subunits include another ATP-binding subunit (TIGR03796), which has an N-terminal leader sequence cleavage domain, and an HlyD homolog (TIGR03794). In a number of genomes, members of protein families related to nitrile hydratase alpha subunit or to nif11 have undergone paralogous family expansions, with members possessing a putative bacteriocin cleavage region ending with a classic Gly-Gly motif. Those sets of putative bacteriocins, members of this protein family and its partners TIGR03794 and TIGR03796, and cyclodehydratase/docking scaffold fusion proteins of thiazole/oxazole biosynthesis frequently show correlated species distribution and co-clustering within many of those genomes. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Biosynthesis of natural products]

Pssm-ID: 274789 [Multi-domain] Cd Length: 686 Bit Score: 116.59 E-value: 9.93e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GdtcmySSAKKIKTSPHERNIGMVFQDFALWPH 94
Cdd:TIGR03797 467 LILDDVSLQIEPGEFVAIVGPSGSGKSTLLRLLLGFETPESGSVFYdG-----QDLAGLDVQAVRRQLGVVLQNGRLMSG 541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   95 mNVFENVAFGLRATkqtnqlrekVEDAIKRVRLQGME---KRYP---H--------ELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:TIGR03797 542 -SIFENIAGGAPLT---------LDEAWEAARMAGLAediRAMPmgmHtvisegggTLSGGQRQRLLIARALVRKPRILL 611

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968  161 FDEPLSALDAILREemrlelmdIVhSIGLTALYVT-----HDQTEAMSmSDQIIVMKQGEVLQKGTPED 224
Cdd:TIGR03797 612 FDEATSALDNRTQA--------IV-SESLERLKVTriviaHRLSTIRN-ADRIYVLDAGRVVQQGTYDE 670

PRK14246

phosphate ABC transporter ATP-binding protein; Provisional

18-238

1.01e-28

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172734 [Multi-domain] Cd Length: 257 Bit Score: 111.29 E-value: 1.01e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEE-------PDKGEIYFGDTCMYSSAKKIKtspheRNIGMVFQDFA 90
Cdd:PRK14246  26 LKDITIKIPNNSIFGIMGPSGSGKSTLLKVLNRLIEiydskikVDGKVLYFGKDIFQIDAIKLR-----KEVGMVFQQPN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LWPHMNVFENVAFGLRA--TKQTNQLREKVEDAIKRVRL-QGMEKRY---PHELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:PRK14246 101 PFPHLSIYDNIAYPLKShgIKEKREIKKIVEECLRKVGLwKEVYDRLnspASQLSGGQQQRLTIARALALKPKVLLMDEP 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 165 LSALDAILREEMRLELMDIVHSIglTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:PRK14246 181 TSMIDIVNSQAIEKLITELKNEI--AIVIVSHNPQQVARVADYVAFLYNGELVEWGSSNEIFTSPKNELTEKYV 252

PRK14258

phosphate ABC transporter ATP-binding protein; Provisional

3-229

2.17e-28

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 184593 [Multi-domain] Cd Length: 261 Bit Score: 110.51 E-value: 2.17e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD-----KGEIYFGDTCMYSsaKKIKTSP 77
Cdd:PRK14258   8 IKVNNLSFYYDTQKILEGVSMEIYQSKVTAIIGPSGCGKSTFLKCLNRMNELEsevrvEGRVEFFNQNIYE--RRVNLNR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  78 HERNIGMVFQDFALWPhMNVFENVAFGLRAT--KQTNQLREKVEDAIKRVRLQGMEKRYPH----ELSGGQQQRVAFARA 151
Cdd:PRK14258  86 LRRQVSMVHPKPNLFP-MSVYDNVAYGVKIVgwRPKLEIDDIVESALKDADLWDEIKHKIHksalDLSGGQQQRLCIARA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IVTKPHFILFDEPLSALDAIlrEEMRLElmDIVHSIG----LTALYVTHDQTEAMSMSDQIIVMKQ-----GEVLQKGTP 222
Cdd:PRK14258 165 LAVKPKVLLMDEPCFGLDPI--ASMKVE--SLIQSLRlrseLTMVIVSHNLHQVSRLSDFTAFFKGnenriGQLVEFGLT 240


                 ....*..
gi 446273968 223 EDIYVKP 229
Cdd:PRK14258 241 KKIFNSP 247

PRK13651

cobalt transporter ATP-binding subunit; Provisional

1-225

2.25e-28

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 111.33 E-value: 2.25e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKT-----QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-------------- 61
Cdd:PRK13651   1 MQIKVKNIVKIFNKKlptelKALDNVSVEINQGEFIAIIGQTGSGKTTFIEHLNALLLPDTGTIEWifkdeknkkktkek 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  62 -----GDTCMYSSAKKIKTSPH-ERNIGMVFQdFALWphmNVFE-----NVAFGLRATKQTNQlrEKVEDAIKRVRLQGM 130
Cdd:PRK13651  81 ekvleKLVIQKTRFKKIKKIKEiRRRVGVVFQ-FAEY---QLFEqtiekDIIFGPVSMGVSKE--EAKKRAAKYIELVGL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 131 E----KRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSD 206
Cdd:PRK13651 155 DesylQRSPFELSGGQKRRVALAGILAMEPDFLVFDEPTAGLDPQGVKEI-LEIFDNLNKQGKTIILVTHDLDNVLEWTK 233

                        250
                 ....*....|....*....
gi 446273968 207 QIIVMKQGEVLQKGTPEDI 225
Cdd:PRK13651 234 RTIFFKDGKIIKDGDTYDI 252

PRK10584

putative ABC transporter ATP-binding protein YbbA; Provisional

18-201

3.78e-28

putative ABC transporter ATP-binding protein YbbA; Provisional

Pssm-ID: 182569 [Multi-domain] Cd Length: 228 Bit Score: 109.10 E-value: 3.78e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWPHMNV 97
Cdd:PRK10584  26 LTGVELVVKRGETIALIGESGSGKSTLLAILAGLDDGSSGEVSLVGQPLHQMDEEARAKLRAKHVGFVFQSFMLIPTLNA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVAfgLRATKQTNQLREKVEDAIKRVRLQGMEKRYPH---ELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILRE 174
Cdd:PRK10584 106 LENVE--LPALLRGESSRQSRNGAKALLEQLGLGKRLDHlpaQLSGGEQQRVALARAFNGRPDVLFADEPTGNLDRQTGD 183

                        170       180
                 ....*....|....*....|....*..
gi 446273968 175 EMRLELMDIVHSIGLTALYVTHDQTEA 201
Cdd:PRK10584 184 KIADLLFSLNREHGTTLILVTHDLQLA 210

livG

PRK11300

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

3-225

5.65e-28

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

Pssm-ID: 183080 [Multi-domain] Cd Length: 255 Bit Score: 109.31 E-value: 5.65e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHER-- 80
Cdd:PRK11300   6 LSVSGLMMRFGGLLAVNNVNLEVREQEIVSLIGPNGAGKTTVFNCLTGFYKPTGGTILLRG-------QHIEGLPGHQia 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMV--FQDFALWPHMNVFEN--VA----------FGLRATKQTNQL-REKVEDA---IKRVRLQGMEKRYPHELSGGQ 142
Cdd:PRK11300  79 RMGVVrtFQHVRLFREMTVIENllVAqhqqlktglfSGLLKTPAFRRAeSEALDRAatwLERVGLLEHANRQAGNLAYGQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 143 QQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTP 222
Cdd:PRK11300 159 QRRLEIARCMVTQPEILMLDEPAAGLNPKETKELDELIAELRNEHNVTVLLIEHDMKLVMGISDRIYVVNQGTPLANGTP 238


                 ...
gi 446273968 223 EDI 225
Cdd:PRK11300 239 EEI 241

cbiO

PRK13645

energy-coupling factor transporter ATPase;

16-226

7.65e-28

energy-coupling factor transporter ATPase;

Pssm-ID: 184204 [Multi-domain] Cd Length: 289 Bit Score: 109.71 E-value: 7.65e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPH-ERNIGMVFQdfalWPH 94
Cdd:PRK13645  25 KALNNTSLTFKKNKVTCVIGTTGSGKSTMIQLTNGLIISETGQTIVGDYAIPANLKKIKEVKRlRKEIGLVFQ----FPE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFE-----NVAFG---LRATKQtnQLREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13645 101 YQLFQetiekDIAFGpvnLGENKQ--EAYKKVPELLKLVQLpEDYVKRSPFELSGGQKRRVALAGIIAMDGNTLVLDEPT 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 166 SALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13645 179 GGLDPKGEEDFINLFERLNKEYKKRIIMVTHNMDQVLRIADEVIVMHEGKVISIGSPFEIF 239

ABC_MTABC3_MDL1_MDL2

cd03249

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ...

16-224

9.66e-28

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.

Pssm-ID: 213216 [Multi-domain] Cd Length: 238 Bit Score: 108.01 E-value: 9.66e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmySSAKKIKTSPHERNIGMVFQDFALWPhM 95
Cdd:cd03249   17 PILKGLSLTIPPGKTVALVGSSGCGKSTVVSLLERFYDPTSGEILLDG----VDIRDLNLRWLRSQIGLVSQEPVLFD-G 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFENVAFGLRATKQtnqlrEKVEDAIKRVRL----QGMEKRY-----PH--ELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:cd03249   92 TIAENIRYGKPDATD-----EEVEEAAKKANIhdfiMSLPDGYdtlvgERgsQLSGGQKQRIAIARALLRNPKILLLDEA 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 165 LSALDAILREEMRLELMDIvhSIGLTALYVTHDQTeAMSMSDQIIVMKQGEVLQKGTPED 224
Cdd:cd03249  167 TSALDAESEKLVQEALDRA--MKGRTTIVIAHRLS-TIRNADLIAVLQNGQVVEQGTHDE 223

AztA

NF040873

zinc ABC transporter ATP-binding protein AztA;

12-209

1.11e-27

zinc ABC transporter ATP-binding protein AztA;

Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 106.55 E-value: 1.11e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmyssakkikTSPHERNIGMVFQDFAL 91
Cdd:NF040873   2 YGGRPVLHGVDLTIPAGSLTAVVGPNGSGKSTLLKVLAGVLRPTSGTV---------------RRAGGARVAYVPQRSEV 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 ---WPhMNVFENVAFGLRATKQ-----TNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:NF040873  67 pdsLP-LTVRDLVAMGRWARRGlwrrlTRDDRAAVDDALERVGLADLAGRQLGELSGGQRQRALLAQGLAQEADLLLLDE 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446273968 164 PLSALDAILREEMRlELMDIVHSIGLTALYVTHDQTEAMSMSDQII 209
Cdd:NF040873 146 PTTGLDAESRERII-ALLAEEHARGATVVVVTHDLELVRRADPCVL 190

cbiO

PRK13652

cobalt transporter ATP-binding subunit; Provisional

13-229

1.17e-27

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 172200 [Multi-domain] Cd Length: 277 Bit Score: 109.12 E-value: 1.17e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKtspheRNIGMVFQDfal 91
Cdd:PRK13652  15 GSKEALNNINFIAPRNSRIAVIGPNGAGKSTLFRHFNGILKPTSGSVLIrGEPITKENIREVR-----KFVGLVFQN--- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 wPHMNVF-----ENVAFG-LRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13652  87 -PDDQIFsptveQDIAFGpINLGLDEETVAHRVSSALHMLGLEELRDRVPHHLSGGEKKRVAIAGVIAMEPQVLVLDEPT 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 166 SALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:PRK13652 166 AGLDPQGVKELIDFLNDLPETYGMTVIFSTHQLDLVPEMADYIYVMDKGRIVAYGTVEEIFLQP 229

CP_lyasePhnK

TIGR02323

phosphonate C-P lyase system protein PhnK; Members of this family are the PhnK protein of C-P ...

3-233

2.54e-27

phosphonate C-P lyase system protein PhnK; Members of this family are the PhnK protein of C-P lyase systems for utilization of phosphonates. These systems resemble phosphonatase-based systems in having a three component ABC transporter, where TIGR01097 is the permease, TIGR01098 is the phosphonates binding protein, and TIGR02315 is the ATP-binding cassette (ABC) protein. They differ, however, in having, typically, ten or more additional genes, many of which are believed to form a membrane-associated complex. This protein (PhnK) and the adjacent-encoded PhnL resemble transporter ATP-binding proteins but are suggested, based on mutatgenesis studies, to be part of this complex rather than part of a transporter per se. [Central intermediary metabolism, Phosphorus compounds]

Pssm-ID: 188208 [Multi-domain] Cd Length: 253 Bit Score: 107.61 E-value: 2.54e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGD--------TCMySSAKKIK 74
Cdd:TIGR02323   4 LQVSGLSKSYGGGKGCRDVSFDLYPGEVLGIVGESGSGKSTLLGCLAGRLAPDHGTATYIMrsgaelelYQL-SEAERRR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   75 TSPHErnIGMVFQDFALWPHMNVFE--NVAFGLRATKQTN--QLREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFA 149
Cdd:TIGR02323  83 LMRTE--WGFVHQNPRDGLRMRVSAgaNIGERLMAIGARHygNIRATAQDWLEEVEIdPTRIDDLPRAFSGGMQQRLQIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  150 RAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:TIGR02323 161 RNLVTRPRLVFMDEPTGGLDVSVQARLLDLLRGLVRDLGLAVIIVTHDLGVARLLAQRLLVMQQGRVVESGLTDQVLDDP 240


                  ....
gi 446273968  230 SHEF 233
Cdd:TIGR02323 241 QHPY 244

btuD

PRK09536

corrinoid ABC transporter ATPase; Reviewed

1-225

3.01e-27

corrinoid ABC transporter ATPase; Reviewed

Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 110.32 E-value: 3.01e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYS-SAKKIKtsphe 79
Cdd:PRK09536   2 PMIDVSDLSVEFGDTTVLDGVDLSVREGSLVGLVGPNGAGKTTLLRAINGTLTPTAGTVLVAGDDVEAlSARAAS----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDFALWPHMNVFENVAFGL-----RATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVT 154
Cdd:PRK09536  77 RRVASVPQDTSLSFEFDVRQVVEMGRtphrsRFDTWTETDRAAVERAMERTGVAQFADRPVTSLSGGERQRVLLARALAQ 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 155 KPHFILFDEPLSALDaILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK09536 157 ATPVLLLDEPTASLD-INHQVRTLELVRRLVDDGKTAVAAIHDLDLAARYCDELVLLADGRVRAAGPPADV 226

type_I_sec_LssB

TIGR03375

type I secretion system ATPase, LssB family; Type I protein secretion is a system in some ...

14-225

3.26e-27

type I secretion system ATPase, LssB family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. This model is related to models TIGR01842 and TIGR01846, and to bacteriocin ABC transporters that cleave their substrates during export. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]

Pssm-ID: 274550 [Multi-domain] Cd Length: 694 Bit Score: 111.88 E-value: 3.26e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALWp 93
Cdd:TIGR03375 477 ETPALDNVSLTIRPGEKVAIIGRIGSGKSTLLKLLLGLYQPTEGSVLLDGV----DIRQIDPADLRRNIGYVPQDPRLF- 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   94 HMNVFENVAFGLRATKQTNQLRekvedAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:TIGR03375 552 YGTLRDNIALGAPYADDEEILR-----AAELAGVTEFVRRHPDgldmqigergrSLSGGQRQAVALARALLRDPPILLLD 626

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968  163 EPLSALDAilREEMRleLMDIVH--SIGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:TIGR03375 627 EPTSAMDN--RSEER--FKDRLKrwLAGKTLVLVTH-RTSLLDLVDRIIVMDNGRIVADGPKDQV 686

urea_trans_UrtE

TIGR03410

urea ABC transporter, ATP-binding protein UrtE; Members of this protein family are ABC ...

4-238

3.88e-27

urea ABC transporter, ATP-binding protein UrtE; Members of this protein family are ABC transporter ATP-binding subunits associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 274567 [Multi-domain] Cd Length: 230 Bit Score: 106.46 E-value: 3.88e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKI-KTSPHER-- 80
Cdd:TIGR03410   2 EVSNLNVYYGQSHILRGVSLEVPKGEVTCVLGRNGVGKTTLLKTLMGLLPVKSGSIRLDG-------EDItKLPPHERar 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   81 -NIGMVFQDFALWPHMNVFENVAFGLRATKQTNQlreKVEDAIKRV--RLQGMEKRYPHELSGGQQQRVAFARAIVTKPH 157
Cdd:TIGR03410  75 aGIAYVPQGREIFPRLTVEENLLTGLAALPRRSR---KIPDEIYELfpVLKEMLGRRGGDLSGGQQQQLAIARALVTRPK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  158 FILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIyvkpSHEFVAKF 237
Cdd:TIGR03410 152 LLLLDEPTEGIQPSIIKDIGRVIRRLRAEGGMAILLVEQYLDFARELADRYYVMERGRVVASGAGDEL----DEDKVRRY 227


                  .
gi 446273968  238 V 238
Cdd:TIGR03410 228 L 228

cbiO

PRK13642

energy-coupling factor transporter ATPase;

18-226

5.01e-27

energy-coupling factor transporter ATPase;

Pssm-ID: 184202 [Multi-domain] Cd Length: 277 Bit Score: 107.49 E-value: 5.01e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKtspheRNIGMVFQD-FALWPHM 95
Cdd:PRK13642  23 LNGVSFSITKGEWVSIIGQNGSGKSTTARLIDGLFEEFEGKVKIdGELLTAENVWNLR-----RKIGMVFQNpDNQFVGA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILRE 174
Cdd:PRK13642  98 TVEDDVAFGMENQGiPREEMIKRVDEALLAVNMLDFKTREPARLSGGQKQRVAVAGIIALRPEIIILDESTSMLDPTGRQ 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446273968 175 EMRLELMDIVHSIGLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13642 178 EIMRVIHEIKEKYQLTVLSITHDLDEAAS-SDRILVMKAGEIIKEAAPSELF 228

PRK10261

glutathione transporter ATP-binding protein; Provisional

28-238

5.70e-27

glutathione transporter ATP-binding protein; Provisional

Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 111.10 E-value: 5.70e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG----DTCmysSAKKIKtsPHERNIGMVFQD--FALWPHMNVFENV 101
Cdd:PRK10261 350 GETLSLVGESGSGKSTTGRALLRLVESQGGEIIFNgqriDTL---SPGKLQ--ALRRDIQFIFQDpyASLDPRQTVGDSI 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 102 AFGLRATK--QTNQLREKVEDAIKRVRLQGMEK-RYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRL 178
Cdd:PRK10261 425 MEPLRVHGllPGKAAAARVAWLLERVGLLPEHAwRYPHEFSGGQRQRICIARALALNPKVIIADEAVSALDVSIRGQIIN 504

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 179 ELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFV 238
Cdd:PRK10261 505 LLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVEIGPRRAVFENPQHPYTRKLM 564

cbiO

PRK13649

energy-coupling factor transporter ATPase;

17-226

6.37e-27

energy-coupling factor transporter ATPase;

Pssm-ID: 184208 [Multi-domain] Cd Length: 280 Bit Score: 107.14 E-value: 6.37e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQdfalWPHMN 96
Cdd:PRK13649  22 ALFDVNLTIEDGSYTAFIGHTGSGKSTIMQLLNGLHVPTQGSVRVDDTLITSTSKNKDIKQIRKKVGLVFQ----FPESQ 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 VFE-----NVAFGLRATKQTNQLREKVedAIKRVRLQGMEK----RYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:PRK13649  98 LFEetvlkDVAFGPQNFGVSQEEAEAL--AREKLALVGISEslfeKNPFELSGGQMRRVAIAGILAMEPKILVLDEPTAG 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 168 LDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13649 176 LDPKGRKEL-MTLFKKLHQSGMTIVLVTHLMDDVANYADFVYVLEKGKLVLSGKPKDIF 233

ABCC_bacteriocin_exporters

cd03245

ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ...

14-220

2.39e-26

ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane.

Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 103.82 E-value: 2.39e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALWp 93
Cdd:cd03245   16 EIPALDNVSLTIRAGEKVAIIGRVGSGKSTLLKLLAGLYKPTSGSVLLDGT----DIRQLDPADLRRNIGYVPQDVTLF- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  94 HMNVFENVAFGLRATKQtnqlrEKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:cd03245   91 YGTLRDNITLGAPLADD-----ERILRAAELAGVTDFVNKHPNgldlqigergrGLSGGQRQAVALARALLNDPPILLLD 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446273968 163 EPLSALDaiLREEMRLelmdiVHSI-----GLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03245  166 EPTSAMD--MNSEERL-----KERLrqllgDKTLIIITH-RPSLLDLVDRIIVMDSGRIVADG 220

PRK13537

nodulation factor ABC transporter ATP-binding protein NodI;

3-225

4.15e-26

nodulation factor ABC transporter ATP-binding protein NodI;

Pssm-ID: 237420 [Multi-domain] Cd Length: 306 Bit Score: 105.27 E-value: 4.15e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAkkiktsPHER-N 81
Cdd:PRK13537   8 IDFRNVEKRYGDKLVVDGLSFHVQRGECFGLLGPNGAGKTTTLRMLLGLTHPDAGSISLCGEPVPSRA------RHARqR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVA-----FGLRATkqtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:PRK13537  82 VGVVPQFDNLDPDFTVRENLLvfgryFGLSAA----AARALVPPLLEFAKLENKADAKVGELSGGMKRRLTLARALVNDP 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 157 HFILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK13537 158 DVLVLDEPTTGLDPQARHLMWERLRSLLAR-GKTILLTTHFMEEAERLCDRLCVIEEGRKIAEGAPHAL 225

cbiO

PRK13638

energy-coupling factor ABC transporter ATP-binding protein;

6-226

9.05e-26

energy-coupling factor ABC transporter ATP-binding protein;

Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 103.93 E-value: 9.05e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   6 SGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKTsphERNIGM 84
Cdd:PRK13638   5 SDLWFRYQDEPVLKGLNLDFSLSPVTGLVGANGCGKSTLFMNLSGLLRPQKGAVLWqGKPLDYSKRGLLAL---RQQVAT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VFQDfalwPHMNVF-----ENVAFGLRATK-QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:PRK13638  82 VFQD----PEQQIFytdidSDIAFSLRNLGvPEAEITRRVDEALTLVDAQHFRHQPIQCLSHGQKKRVAIAGALVLQARY 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 159 ILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK13638 158 LLLDEPTAGLDPAGRTQMIAIIRRIVAQ-GNHVIISSHDIDLIYEISDAVYVLRQGQILTHGAPGEVF 224

PRK10895

lipopolysaccharide ABC transporter ATP-binding protein; Provisional

8-225

1.01e-25

lipopolysaccharide ABC transporter ATP-binding protein; Provisional

Pssm-ID: 182817 [Multi-domain] Cd Length: 241 Bit Score: 103.05 E-value: 1.01e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   8 LEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSP-HER---NIG 83
Cdd:PRK10895   9 LAKAYKGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDAGNIIIDD-------EDISLLPlHARarrGIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  84 MVFQDFALWPHMNVFENV--AFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:PRK10895  82 YLPQEASIFRRLSVYDNLmaVLQIRDDLSAEQREDRANELMEEFHIEHLRDSMGQSLSGGERRRVEIARALAANPKFILL 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 162 DEPLSALDAILREEMRlELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK10895 162 DEPFAGVDPISVIDIK-RIIEHLRDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEI 224

PRK10247

putative ABC transporter ATP-binding protein YbbL; Provisional

13-211

1.66e-25

putative ABC transporter ATP-binding protein YbbL; Provisional

Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 101.71 E-value: 1.66e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHER---NIGMVFQDF 89
Cdd:PRK10247  18 GDAKILNNISFSLRAGEFKLITGPSGCGKSTLLKIVASLISPTSGTLLFEG-------EDISTLKPEIyrqQVSYCAQTP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALWPHmNVFENVAFGLRATKQTNQlREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSAL 168
Cdd:PRK10247  91 TLFGD-TVYDNLIFPWQIRNQQPD-PAIFLDDLERFALpDTILTKNIAELSGGEKQRISLIRNLQFMPKVLLLDEITSAL 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446273968 169 DailrEEMRLELMDIVHSI----GLTALYVTHDQTEaMSMSDQIIVM 211
Cdd:PRK10247 169 D----ESNKHNVNEIIHRYvreqNIAVLWVTHDKDE-INHADKVITL 210

ccmA

TIGR01189

heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein ...

13-170

3.01e-25

heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]

Pssm-ID: 273491 [Multi-domain] Cd Length: 198 Bit Score: 100.51 E-value: 3.01e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHeRNIGMVFQDFALW 92
Cdd:TIGR01189  11 GERMLFEGLSFTLNAGEALQVTGPNGIGKTTLLRILAGLLRPDSGEVRWNGT----PLAEQRDEPH-ENILYLGHLPGLK 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968   93 PHMNVFENVAFgLRATKQTNQLreKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:TIGR01189  86 PELSALENLHF-WAAIHGGAQR--TIEDALAAVGLTGFEDLPAAQLSAGQQRRLALARLWLSRRPLWILDEPTTALDK 160

PRK14271

phosphate ABC transporter ATP-binding protein; Provisional

31-239

4.25e-25

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172759 [Multi-domain] Cd Length: 276 Bit Score: 102.10 E-value: 4.25e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  31 TTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCM--YSSAKKIKTSPHERNIGMVFQDFALWPhMNVFENVAFGLRAT 108
Cdd:PRK14271  50 TSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLggRSIFNYRDVLEFRRRVGMLFQRPNPFP-MSIMDNVLAGVRAH 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 109 KQT--NQLREKVEDAIKRVRL-QGMEKRY---PHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRlelmD 182
Cdd:PRK14271 129 KLVprKEFRGVAQARLTEVGLwDAVKDRLsdsPFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIE----E 204

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 183 IVHSIG--LTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFVAKFVG 239
Cdd:PRK14271 205 FIRSLAdrLTVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVA 263

PRK13536

nodulation factor ABC transporter ATP-binding protein NodI;

1-225

1.22e-24

nodulation factor ABC transporter ATP-binding protein NodI;

Pssm-ID: 237419 [Multi-domain] Cd Length: 340 Bit Score: 102.22 E-value: 1.22e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKtspheR 80
Cdd:PRK13536  40 VAIDLAGVSKSYGDKAVVNGLSFTVASGECFGLLGPNGAGKSTIARMILGMTSPDAGKITVLGVPVPARARLAR-----A 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDFALWPHMNVFEN-VAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:PRK13536 115 RIGVVPQFDNLDLEFTVRENlLVFGRYFGMSTREIEAVIPSLLEFARLESKADARVSDLSGGMKRRLTLARALINDPQLL 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 160 LFDEPLSALDAILR----EEMRLELmdivhSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK13536 195 ILDEPTTGLDPHARhliwERLRSLL-----ARGKTILLTTHFMEEAERLCDRLCVLEAGRKIAEGRPHAL 259

cbiO

PRK13641

energy-coupling factor transporter ATPase;

14-229

1.46e-24

energy-coupling factor transporter ATPase;

Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 100.67 E-value: 1.46e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYS--SAKKIKTSphERNIGMVFQdfal 91
Cdd:PRK13641  19 EKKGLDNISFELEEGSFVALVGHTGSGKSTLMQHFNALLKPSSGTITIAGYHITPetGNKNLKKL--RKKVSLVFQ---- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 WPHMNVFEN-----VAFGLRATKQTNQ-LREKVEDAIKRVRL-QGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:PRK13641  93 FPEAQLFENtvlkdVEFGPKNFGFSEDeAKEKALKWLKKVGLsEDLISKSPFELSGGQMRRVAIAGVMAYEPEILCLDEP 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 165 LSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:PRK13641 173 AAGLDPEGRKEM-MQLFKDYQKAGHTVILVTHNMDDVAEYADDVLVLEHGKLIKHASPKEIFSDK 236

cbiO

PRK13646

energy-coupling factor transporter ATPase;

16-273

1.51e-24

energy-coupling factor transporter ATPase;

Pssm-ID: 184205 [Multi-domain] Cd Length: 286 Bit Score: 100.62 E-value: 1.51e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQdfalWPHM 95
Cdd:PRK13646  21 QAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQ----FPES 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFEN-----VAFGlraTKQTNQLREKVEDAIKRVRLQ-GMEK----RYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13646  97 QLFEDtvereIIFG---PKNFKMNLDEVKNYAHRLLMDlGFSRdvmsQSPFQMSGGQMRKIAIVSILAMNPDIIVLDEPT 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 166 SALDAilreEMRLELMDIVHSIGL----TALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI-----YVKPSHEFVAK 236
Cdd:PRK13646 174 AGLDP----QSKRQVMRLLKSLQTdenkTIILVSHDMNEVARYADEVIVMKEGSIVSQTSPKELfkdkkKLADWHIGLPE 249

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 446273968 237 FVgKANWLVEGKQMIRPEHVSWTKNEVCEMYTgEIQH 273
Cdd:PRK13646 250 IV-QLQYDFEQKYQTKLKDIALTEEEFVSLYK-EWQH 284

met_CoM_red_A2

TIGR03269

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...

3-257

1.90e-24

Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 103.34 E-value: 1.90e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLE--EPDKGEIYF-----------------GD 63
Cdd:TIGR03269   1 IEVKNLTKKFDGKEVLKNISFTIEEGEVLGILGRSGAGKSVLMHVLRGMDqyEPTSGRIIYhvalcekcgyverpskvGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   64 TC-------------MYSSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFGLratkqtNQLREKVEDAIKR----VR 126
Cdd:TIGR03269  81 PCpvcggtlepeevdFWNLSDKLRRRIRKRIAIMLQRTFALYGDDTVLDNVLEAL------EEIGYEGKEAVGRavdlIE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  127 LQGMEKRYPH---ELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHdQTEAMS 203
Cdd:TIGR03269 155 MVQLSHRITHiarDLSGGEKQRVVLARQLAKEPFLFLADEPTGTLDPQTAKLVHNALEEAVKASGISMVLTSH-WPEVIE 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968  204 -MSDQIIVMKQGEVLQKGTPEdiyvkpshEFVAKF------VGKANWLVEGKQMIRPEHVS 257
Cdd:TIGR03269 234 dLSDKAIWLENGEIKEEGTPD--------EVVAVFmegvseVEKECEVEVGEPIIKVRNVS 286

PRK10535

macrolide ABC transporter ATP-binding protein/permease MacB;

13-237

1.44e-23

macrolide ABC transporter ATP-binding protein/permease MacB;

Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 101.34 E-value: 1.44e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALW 92
Cdd:PRK10535  19 EQVEVLKGISLDIYAGEMVAIVGASGSGKSTLMNILGCLDKPTSGTYRVAGQDVATLDADALAQLRREHFGFIFQRYHLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHMNVFENVAF-GLRATKQTNQLREKVEDAIKRVrlqGMEKR---YPHELSGGQQQRVAFARAIVTKPHFILFDEPLSAL 168
Cdd:PRK10535  99 SHLTAAQNVEVpAVYAGLERKQRLLRAQELLQRL---GLEDRveyQPSQLSGGQQQRVSIARALMNGGQVILADEPTGAL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 169 DAILREemrlELMDIVHSI---GLTALYVTHDQTEAmSMSDQIIVMKQGEVLQ----------KGTPEDIYVKPS--HEF 233
Cdd:PRK10535 176 DSHSGE----EVMAILHQLrdrGHTVIIVTHDPQVA-AQAERVIEIRDGEIVRnppaqekvnvAGGTEPVVNTASgwRQF 250


                 ....
gi 446273968 234 VAKF 237
Cdd:PRK10535 251 VSGF 254

cbiO

PRK13631

cobalt transporter ATP-binding subunit; Provisional

33-229

1.69e-23

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237451 [Multi-domain] Cd Length: 320 Bit Score: 98.38 E-value: 1.69e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYFGD-----------TCMYSSAKKIKTSPH-ERNIGMVFQdfalWPHMNVFE- 99
Cdd:PRK13631  57 IIGNSGSGKSTLVTHFNGLIKSKYGTIQVGDiyigdkknnheLITNPYSKKIKNFKElRRRVSMVFQ----FPEYQLFKd 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 100 ----NVAFGLRATKQT-NQLREKVEDAIKRVRLQ-GMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILR 173
Cdd:PRK13631 133 tiekDIMFGPVALGVKkSEAKKLAKFYLNKMGLDdSYLERSPFGLSGGQKRRVAIAGILAIQPEILIFDEPTAGLDPKGE 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 174 EEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:PRK13631 213 HEM-MQLILDAKANNKTVFVITHTMEHVLEVADEVIVMDKGKILKTGTPYEIFTDQ 267

ABCC_Protease_Secretion

cd03246

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ...

28-216

2.04e-23

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA.

Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 94.59 E-value: 2.04e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALWPHmNVFENVafglra 107
Cdd:cd03246   28 GESLAIIGPSGSGKSTLARLILGLLRPTSGRVRLDGA----DISQWDPNELGDHVGYLPQDDELFSG-SIAENI------ 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 108 tkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSALDaILREEMRLELMDIVHSI 187
Cdd:cd03246   97 ------------------------------LSGGQRQRLGLARALYGNPRILVLDEPNSHLD-VEGERALNQAIAALKAA 145

                        170       180
                 ....*....|....*....|....*....
gi 446273968 188 GLTALYVTHdQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03246  146 GATRIVIAH-RPETLASADRILVLEDGRV 173

phnK

PRK11701

phosphonate C-P lyase system protein PhnK; Provisional

4-233

2.08e-23

phosphonate C-P lyase system protein PhnK; Provisional

Pssm-ID: 183280 [Multi-domain] Cd Length: 258 Bit Score: 96.92 E-value: 2.08e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-----GDTCMYSSAKKIKTSPH 78
Cdd:PRK11701   8 SVRGLTKLYGPRKGCRDVSFDLYPGEVLGIVGESGSGKTTLLNALSARLAPDAGEVHYrmrdgQLRDLYALSEAERRRLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFE--NVAFGLRATKQTN--QLREKVEDAIKRVRLQgmEKR---YPHELSGGQQQRVAFARA 151
Cdd:PRK11701  88 RTEWGFVHQHPRDGLRMQVSAggNIGERLMAVGARHygDIRATAGDWLERVEID--AARiddLPTTFSGGMQQRLQIARN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 152 IVTKPHFILFDEPLSALD----AILreemrLELM-DIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK11701 166 LVTHPRLVFMDEPTGGLDvsvqARL-----LDLLrGLVRELGLAVVIVTHDLAVARLLAHRLLVMKQGRVVESGLTDQVL 240


                 ....*..
gi 446273968 227 VKPSHEF 233
Cdd:PRK11701 241 DDPQHPY 247

CydC

TIGR02868

thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ...

13-197

2.17e-23

thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.

Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 100.51 E-value: 2.17e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDfalw 92
Cdd:TIGR02868 346 GAPPVLDGVSLDLPPGERVAILGPSGSGKSTLLATLAGLLDPLQGEVTLDGV----PVSSLDQDEVRRRVSVCAQD---- 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   93 PHM---NVFENVAFGlratkQTNQLREKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHF 158
Cdd:TIGR02868 418 AHLfdtTVRENLRLA-----RPDATDEELWAALERVGLADWLRALPDgldtvlgeggaRLSGGERQRLALARALLADAPI 492

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 446273968  159 ILFDEPLSALDAILREEMrLELMDIVHSiGLTALYVTHD 197
Cdd:TIGR02868 493 LLLDEPTEHLDAETADEL-LEDLLAALS-GRTVVLITHH 529

PRK10575

Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;

18-225

2.45e-23

Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;

Pssm-ID: 182561 [Multi-domain] Cd Length: 265 Bit Score: 96.78 E-value: 2.45e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIktspHERNIGMVFQDFALWPHMNV 97
Cdd:PRK10575  27 LHPLSLTFPAGKVTGLIGHNGSGKSTLLKMLGRHQPPSEGEILLDAQPLESWSSKA----FARKVAYLPQQLPAAEGMTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVAFG-------LRATKQTNqlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:PRK10575 103 RELVAIGrypwhgaLGRFGAAD--REKVEEAISLVGLKPLAHRLVDSLSGGERQRAWIAMLVAQDSRCLLLDEPTSALDI 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 171 ilreEMRLELMDIVHSI----GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK10575 181 ----AHQVDVLALVHRLsqerGLTVIAVLHDINMAARYCDYLVALRGGEMIAQGTPAEL 235

PRK10261

glutathione transporter ATP-binding protein; Provisional

13-277

6.89e-23

glutathione transporter ATP-binding protein; Provisional

Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 99.16 E-value: 6.89e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKT----TLLRMIagleEPDKGEIYFGDTCMYSSAKKI--------KTSPHER 80
Cdd:PRK10261  27 QKIAAVRNLSFSLQRGETLAIVGESGSGKSvtalALMRLL----EQAGGLVQCDKMLLRRRSRQVielseqsaAQMRHVR 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 --NIGMVFQD--FALWPHMNVFENVAFGLRATKQTNqlREKVEDAIKR----VRL---QGMEKRYPHELSGGQQQRVAFA 149
Cdd:PRK10261 103 gaDMAMIFQEpmTSLNPVFTVGEQIAESIRLHQGAS--REEAMVEAKRmldqVRIpeaQTILSRYPHQLSGGMRQRVMIA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 150 RAIVTKPHFILFDEPLSALDAILREEMrLELMDIVHS-IGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:PRK10261 181 MALSCRPAVLIADEPTTALDVTIQAQI-LQLIKVLQKeMSMGVIFITHDMGVVAEIADRVLVMYQGEAVETGSVEQIFHA 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 446273968 229 PSHEFVAKFVGKANWLVEGKQMIRPEHVSWTKNEVCEMYTGEIQHVTYV 277
Cdd:PRK10261 260 PQHPYTRALLAAVPQLGAMKGLDYPRRFPLISLEHPAKQEPPIEQDTVV 308

PRK10253

iron-enterobactin ABC transporter ATP-binding protein;

12-225

7.01e-23

iron-enterobactin ABC transporter ATP-binding protein;

Pssm-ID: 182336 [Multi-domain] Cd Length: 265 Bit Score: 95.82 E-value: 7.01e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKIKtspheRNIGMVFQDFA 90
Cdd:PRK10253  17 YGKYTVAENLTVEIPDGHFTAIIGPNGCGKSTLLRTLSRLMTPAHGHVWLdGEHIQHYASKEVA-----RRIGLLAQNAT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LWPHMNVFENVAFGlRATKQT--NQLREKVEDAIKR-VRLQG---MEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:PRK10253  92 TPGDITVQELVARG-RYPHQPlfTRWRKEDEEAVTKaMQATGithLADQSVDTLSGGQRQRAWIAMVLAQETAIMLLDEP 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 165 LSALDaILREEMRLELM-DIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK10253 171 TTWLD-ISHQIDLLELLsELNREKGYTLAAVLHDLNQACRYASHLIALREGKIVAQGAPKEI 231

YddA

COG4178

ABC-type uncharacterized transport system, permease and ATPase components [General function ...

18-176

1.11e-22

ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only];

Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 98.34 E-value: 1.11e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF--GDTCMYSSAKkiktsphernigmvfqdfalwPHM 95
Cdd:COG4178  379 LEDLSLSLKPGERLLITGPSGSGKSTLLRAIAGLWPYGSGRIARpaGARVLFLPQR---------------------PYL 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 ---NVFENVAFGLRATKQTnqlREKVEDAIKRVRLQGM------EKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:COG4178  438 plgTLREALLYPATAEAFS---DAELREALEAVGLGHLaerldeEADWDQVLSLGEQQRLAFARLLLHKPDWLFLDEATS 514

                        170
                 ....*....|
gi 446273968 167 ALDAILREEM 176
Cdd:COG4178  515 ALDEENEAAL 524

PRK13539

cytochrome c biogenesis protein CcmA; Provisional

26-170

1.43e-22

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 93.40 E-value: 1.43e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFgL 105
Cdd:PRK13539  26 AAGEALVLTGPNGSGKTTLLRLIAGLLPPAAGTIKLDG-------GDIDDPDVAEACHYLGHRNAMKPALTVAENLEF-W 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 106 RATKQTNQLRekVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:PRK13539  98 AAFLGGEELD--IAAALEAVGLAPLAHLPFGYLSAGQKRRVALARLLVSNRPIWILDEPTAALDA 160

znuC

PRK09544

high-affinity zinc transporter ATPase; Reviewed

11-237

1.96e-22

high-affinity zinc transporter ATPase; Reviewed

Pssm-ID: 181939 [Multi-domain] Cd Length: 251 Bit Score: 94.03 E-value: 1.96e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  11 NFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGeiyfgdtcmyssakKIKTSPHERnIGMVFQDFA 90
Cdd:PRK09544  13 SFGQRRVLSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVAPDEG--------------VIKRNGKLR-IGYVPQKLY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LWPHMNVfenvafglrATKQTNQLREKVED-----AIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK09544  78 LDTTLPL---------TVNRFLRLRPGTKKedilpALKRVQAGHLIDAPMQKLSGGETQRVLLARALLNRPQLLVLDEPT 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 166 SALDAilreEMRLELMDIV----HSIGLTALYVTHDQTEAMSMSDQIIVMKQgEVLQKGTPEDIYVKPshEFVAKF 237
Cdd:PRK09544 149 QGVDV----NGQVALYDLIdqlrRELDCAVLMVSHDLHLVMAKTDEVLCLNH-HICCSGTPEVVSLHP--EFISMF 217

PRK13538

cytochrome c biogenesis heme-transporting ATPase CcmA;

21-170

2.44e-22

cytochrome c biogenesis heme-transporting ATPase CcmA;

Pssm-ID: 184125 [Multi-domain] Cd Length: 204 Bit Score: 92.56 E-value: 2.44e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  21 LQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHErnigmvFQDFALW-------- 92
Cdd:PRK13538  20 LSFTLNAGELVQIEGPNGAGKTSLLRILAGLARPDAGEVLWQG-------EPIRRQRDE------YHQDLLYlghqpgik 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968  93 PHMNVFENVAFGLRATKQTNqlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:PRK13538  87 TELTALENLRFYQRLHGPGD--DEALWEALAQVGLAGFEDVPVRQLSAGQQRRVALARLWLTRAPLWILDEPFTAIDK 162

ABCD_peroxisomal_ALDP

cd03223

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ...

18-199

3.31e-22

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic).

Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 91.45 E-value: 3.31e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmyssakkiktsPHERNIGMVFQDfalwPHMNv 97
Cdd:cd03223   17 LKDLSFEIKPGDRLLITGPSGTGKSSLFRALAGLWPWGSGRIGM---------------PEGEDLLFLPQR----PYLP- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 fenvafglRATkqtnqLREKVedaikrvrlqgmekRYP--HELSGGQQQRVAFARAIVTKPHFILFDEPLSALDailrEE 175
Cdd:cd03223   77 --------LGT-----LREQL--------------IYPwdDVLSGGEQQRLAFARLLLHKPKFVFLDEATSALD----EE 125

                        170       180
                 ....*....|....*....|....
gi 446273968 176 MRLELMDIVHSIGLTALYVTHDQT 199
Cdd:cd03223  126 SEDRLYQLLKELGITVISVGHRPS 149

bacteriocin_ABC

TIGR01193

ABC-type bacteriocin transporter; This model describes ABC-type bacteriocin transporter. The ...

2-225

3.56e-22

ABC-type bacteriocin transporter; This model describes ABC-type bacteriocin transporter. The amino terminal domain (pfam03412) processes the N-terminal leader peptide from the bacteriocin while C-terminal domains resemble ABC transporter membrane protein and ATP-binding cassette domain. In general, bacteriocins are agents which are responsible for killing or inhibiting the closely related species or even different strains of the same species. Bacteriocins are usually encoded by bacterial plasmids. Bacteriocins are named after the species and hence in literature one encounters various names e.g., leucocin from Leuconostic geldium; pedicocin from Pedicoccus acidilactici; sakacin from Lactobacillus sake etc. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair, Transport and binding proteins, Other]

Pssm-ID: 130261 [Multi-domain] Cd Length: 708 Bit Score: 97.12 E-value: 3.56e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    2 DIKISGLEKNFG-KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHER 80
Cdd:TIGR01193 473 DIVINDVSYSYGyGSNILSDISLTIKMNSKTTIVGMSGSGKSTLAKLLVGFFQARSGEILLNGF----SLKDIDRHTLRQ 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   81 NIGMVFQDfalwPHM---NVFENVAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHEL-------SGGQQQRVAFAR 150
Cdd:TIGR01193 549 FINYLPQE----PYIfsgSILENLLLGAKENVSQDEIWAACEIAEIKDDIENMPLGYQTELseegssiSGGQKQRIALAR 624

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968  151 AIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSiglTALYVTHDQTEAmSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:TIGR01193 625 ALLTDSKVLILDESTSNLDTITEKKIVNNLLNLQDK---TIIFVAHRLSVA-KQSDKIIVLDHGKIIEQGSHDEL 695

ABCC_Hemolysin

cd03252

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ...

17-225

9.50e-22

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy.

Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 92.16 E-value: 9.50e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKkiktSPHERNIGMVFQDFALWpHMN 96
Cdd:cd03252   17 ILDNISLRIKPGEVVGIVGRSGSGKSTLTKLIQRFYVPENGRVLVDGHDLALADP----AWLRRQVGVVLQENVLF-NRS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 VFENVAFGLRATKqtnqlREKVEDAikrVRLQG-----MEKRYPHE---------LSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:cd03252   92 IRDNIALADPGMS-----MERVIEA---AKLAGahdfiSELPEGYDtivgeqgagLSGGQRQRIAIARALIHNPRILIFD 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 163 EPLSALDAilreEMRLELMDIVHSI--GLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDI 225
Cdd:cd03252  164 EATSALDY----ESEHAIMRNMHDIcaGRTVIIIAHRLSTVKN-ADRIIVMEKGRIVEQGSHDEL 223

oppD

PRK09473

oligopeptide transporter ATP-binding component; Provisional

13-233

9.96e-22

oligopeptide transporter ATP-binding component; Provisional

Pssm-ID: 181888 [Multi-domain] Cd Length: 330 Bit Score: 93.64 E-value: 9.96e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDkGEIyfGDTCMYSSAKKIKTSPHERN------IGMVF 86
Cdd:PRK09473  27 GDVTAVNDLNFSLRAGETLGIVGESGSGKSQTAFALMGLLAAN-GRI--GGSATFNGREILNLPEKELNklraeqISMIF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  87 QD--FALWPHMNVFENVAFGLRATKQTNQlREKVEDAIKR---VRLQGMEKR---YPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:PRK09473 104 QDpmTSLNPYMRVGEQLMEVLMLHKGMSK-AEAFEESVRMldaVKMPEARKRmkmYPHEFSGGMRQRVMIAMALLCRPKL 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 159 ILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PRK09473 183 LIADEPTTALDVTVQAQIMTLLNELKREFNTAIIMITHDLGVVAGICDKVLVMYAGRTMEYGNARDVFYQPSHPY 257

ATM1

COG5265

ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ...

28-221

1.15e-21

ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 95.66 E-value: 1.15e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakKIKTSPHE---RNIGMVFQDFALWphmN--VFENVA 102
Cdd:COG5265  384 GKTVAIVGPSGAGKSTLARLLFRFYDVTSGRILIDGQ-------DIRDVTQAslrAAIGIVPQDTVLF---NdtIAYNIA 453

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 103 FG-LRATkqtnqlREKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFDEPLSALD- 169
Cdd:COG5265  454 YGrPDAS------EEEVEAAARAAQIHDFIESLPDgydtrvgerglKLSGGEKQRVAIARTLLKNPPILIFDEATSALDs 527

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 170 ----AILReemrlELMDIvhSIGLTALYVTH------DqteamsmSDQIIVMKQGEVLQKGT 221
Cdd:COG5265  528 rterAIQA-----ALREV--ARGRTTLVIAHrlstivD-------ADEILVLEAGRIVERGT 575

3a01208

TIGR00958

Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]

16-229

2.79e-21

Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 94.40 E-value: 2.79e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKTSPH---ERNIGMVFQDFALW 92
Cdd:TIGR00958 495 PVLKGLTFTLHPGEVVALVGPSGSGKSTVAALLQNLYQPTGGQVLL-------DGVPLVQYDHhylHRQVALVGQEPVLF 567

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   93 PHmNVFENVAFGLRATKQtNQLREKVEDAIKRVRLQGMEKRYPHE-------LSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:TIGR00958 568 SG-SVRENIAYGLTDTPD-EEIMAAAKAANAHDFIMEFPNGYDTEvgekgsqLSGGQKQRIAIARALVRKPRVLILDEAT 645

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968  166 SALDAilreEMRLELMDIVHSIGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:TIGR00958 646 SALDA----ECEQLLQESRSRASRTVLLIAH-RLSTVERADQILVLKKGSVVEMGTHKQLMEDQ 704

livF

PRK11614

high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;

3-221

2.81e-21

high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;

Pssm-ID: 183231 [Multi-domain] Cd Length: 237 Bit Score: 90.71 E-value: 2.81e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIKTSpher 80
Cdd:PRK11614   6 LSFDKVSAHYGKIQALHEVSLHINQGEIVTLIGANGAGKTTLLGTLCGDPRATSGRIVFDgkDITDWQTAKIMREA---- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 nIGMVFQDFALWPHMNVFENVAF-GLRATKQTNQLRekvedaIKRV-----RLQGMEKRYPHELSGGQQQRVAFARAIVT 154
Cdd:PRK11614  82 -VAIVPEGRRVFSRMTVEENLAMgGFFAERDQFQER------IKWVyelfpRLHERRIQRAGTMSGGEQQMLAIGRALMS 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 155 KPHFILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGT 221
Cdd:PRK11614 155 QPRLLLLDEPSLGLAPIIIQQI-FDTIEQLREQGMTIFLVEQNANQALKLADRGYVLENGHVVLEDT 220

ABC_CcmA_heme_exporter

cd03231

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ...

27-170

3.19e-21

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE.

Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 89.47 E-value: 3.19e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  27 QGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIktsphERNIGMVFQDFALWPHMNVFENVAFgLR 106
Cdd:cd03231   25 AGEALQVTGPNGSGKTTLLRILAGLSPPLAGRVLLNGGPLDFQRDSI-----ARGLLYLGHAPGIKTTLSVLENLRF-WH 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968 107 ATKQTNQlrekVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:cd03231   99 ADHSDEQ----VEEALARVGLNGFEDRPVAQLSAGQQRRVALARLLLSGRPLWILDEPTTALDK 158

ArpD

COG4618

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular ...

28-225

3.43e-21

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport];

Pssm-ID: 443660 [Multi-domain] Cd Length: 563 Bit Score: 94.04 E-value: 3.43e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSakkiktSPHE--RNIGMVFQDFALWPHmNVFENVA-FG 104
Cdd:COG4618  358 GEVLGVIGPSGSGKSTLARLLVGVWPPTAGSVRLDGADLSQW------DREElgRHIGYLPQDVELFDG-TIAENIArFG 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 105 lRATkqtnqlREKVEDAIKRVRLQGMEKRYP-----------HELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILr 173
Cdd:COG4618  431 -DAD------PEKVVAAAKLAGVHEMILRLPdgydtrigeggARLSGGQRQRIGLARALYGDPRLVVLDEPNSNLDDEG- 502

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446273968 174 EEMRLELMDIVHSIGLTALYVTHDQTeAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4618  503 EAALAAAIRALKARGATVVVITHRPS-LLAAVDKLLVLRDGRVQAFGPRDEV 553

ABCC_TAP

cd03248

ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ...

15-216

3.45e-21

ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes.

Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 90.22 E-value: 3.45e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKTSPHE---RNIGMVFQDFAL 91
Cdd:cd03248   27 TLVLQDVSFTLHPGEVTALVGPSGSGKSTVVALLENFYQPQGGQVLL-------DGKPISQYEHKylhSKVSLVGQEPVL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 WPHmNVFENVAFGLrATKQTNQLREKVEDAIKRVRLQGMEKRYPHE-------LSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:cd03248  100 FAR-SLQDNIAYGL-QSCSFECVKEAAQKAHAHSFISELASGYDTEvgekgsqLSGGQKQRVAIARALIRNPQVLILDEA 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446273968 165 LSALDAILREEMRLELMDIVHSigLTALYVTHdQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03248  178 TSALDAESEQQVQQALYDWPER--RTVLVIAH-RLSTVERADQILVLDGGRI 226

ABCC_cytochrome_bd

cd03247

ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ...

15-220

1.51e-20

ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism.

Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 86.98 E-value: 1.51e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIktsphERNIGMVFQDfalwPH 94
Cdd:cd03247   15 QQVLKNLSLELKQGEKIALLGRSGSGKSTLLQLLTGDLKPQQGEITLDGVPVSDLEKAL-----SSLISVLNQR----PY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 M---NVFENVafGLRatkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSALDAI 171
Cdd:cd03247   86 LfdtTLRNNL--GRR-------------------------------FSGGERQRLALARILLQDAPIVLLDEPTVGLDPI 132

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446273968 172 LREEMrLELMdIVHSIGLTALYVTHDQTeAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03247  133 TERQL-LSLI-FEVLKDKTLIWITHHLT-GIEHMDKILFLENGKIIMQG 178

ABCC_MRP_domain1

cd03250

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...

17-215

1.58e-20

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 87.91 E-value: 1.58e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSakkikTSPhernigmvfqdfalWpHMN 96
Cdd:cd03250   20 TLKDINLEVPKGELVAIVGPVGSGKSSLLSALLGELEKLSGSVSVPGSIAYVS-----QEP--------------W-IQN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 --VFENVAFGlratKQTNQlrEKVEDAIKRVRLQGMEKRYPH-------E----LSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:cd03250   80 gtIRENILFG----KPFDE--ERYEKVIKACALEPDLEILPDgdlteigEkginLSGGQKQRISLARAVYSDADIYLLDD 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 164 PLSALDA-----ILREEMRLELMDivhsiGLTALYVTHdQTEAMSMSDQIIVMKQGE 215
Cdd:cd03250  154 PLSAVDAhvgrhIFENCILGLLLN-----NKTRILVTH-QLQLLPHADQIVVLDNGR 204

type_I_sec_PrtD

TIGR01842

type I secretion system ABC transporter, PrtD family; Type I protein secretion is a system in ...

13-225

1.71e-20

type I secretion system ABC transporter, PrtD family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. [Protein fate, Protein and peptide secretion and trafficking]

Pssm-ID: 200134 [Multi-domain] Cd Length: 544 Bit Score: 92.03 E-value: 1.71e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgDTCMYSSAKKIKTSPHernIGMVFQDFALW 92
Cdd:TIGR01842 329 GKKPTLRGISFSLQAGEALAIIGPSGSGKSTLARLIVGIWPPTSGSVRL-DGADLKQWDRETFGKH---IGYLPQDVELF 404

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   93 PHmNVFENVA-FGLRATKqtnqlrEKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFIL 160
Cdd:TIGR01842 405 PG-TVAENIArFGENADP------EKIIEAAKLAGVHELILRLPDgydtvigpggaTLSGGQRQRIALARALYGDPKLVV 477

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968  161 FDEPLSALDailrEEMRLELMDIVHSI---GLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:TIGR01842 478 LDEPNSNLD----EEGEQALANAIKALkarGITVVVITH-RPSLLGCVDKILVLQDGRIARFGERDEV 540

ABC_NatA_like

cd03267

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ...

17-220

1.74e-20

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.

Pssm-ID: 213234 [Multi-domain] Cd Length: 236 Bit Score: 88.54 E-value: 1.74e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKiktspHERNIGMVF-QDFALWPHM 95
Cdd:cd03267   36 ALKGISFTIEKGEIVGFIGPNGAGKTTTLKILSGLLQPTSGEVRVAGLVPWKRRKK-----FLRRIGVVFgQKTQLWWDL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFENVAFgLRATKQTN--QLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILR 173
Cdd:cd03267  111 PVIDSFYL-LAAIYDLPpaRFKKRLDELSELLDLEELLDTPVRQLSLGQRMRAEIAAALLHEPEILFLDEPTIGLDVVAQ 189

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446273968 174 EEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03267  190 ENIRNFLKEYNRERGTTVLLTSHYMKDIEALARRVLVIDKGRLLYDG 236

PRK09700

D-allose ABC transporter ATP-binding protein AlsA;

3-240

1.94e-20

D-allose ABC transporter ATP-binding protein AlsA;

Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 91.77 E-value: 1.94e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTsphERNI 82
Cdd:PRK09700   6 ISMAGIGKSFGPVHALKSVNLTVYPGEIHALLGENGAGKSTLMKVLSGIHEPTKGTITINNINYNKLDHKLAA---QLGI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQT--------NQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVT 154
Cdd:PRK09700  83 GIIYQELSVIDELTVLENLYIGRHLTKKVcgvniidwREMRVRAAMMLLRVGLKVDLDEKVANLSISHKQMLEIAKTLML 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 155 KPHFILFDEPLSALDAILREEMRLeLMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKpshEFV 234
Cdd:PRK09700 163 DAKVIIMDEPTSSLTNKEVDYLFL-IMNQLRKEGTAIVYISHKLAEIRRICDRYTVMKDGSSVCSGMVSDVSND---DIV 238


                 ....*.
gi 446273968 235 AKFVGK 240
Cdd:PRK09700 239 RLMVGR 244

ABC_Carb_Monos_II

cd03215

Second domain of the ATP-binding cassette component of monosaccharide transport system; This ...

17-216

2.21e-20

Second domain of the ATP-binding cassette component of monosaccharide transport system; This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. In members of Carb_Monos family the single hydrophobic gene product forms a homodimer, while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.

Pssm-ID: 213182 [Multi-domain] Cd Length: 182 Bit Score: 86.72 E-value: 2.21e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKT-SPHER-NIGMVF-----QDF 89
Cdd:cd03215   15 AVRDVSFEVRAGEIVGIAGLVGNGQTELAEALFGLRPPASGEITLDG-------KPVTRrSPRDAiRAGIAYvpedrKRE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 ALWPHMNVFENVAFGLRatkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:cd03215   88 GLVLDLSVAENIALSSL-------------------------------LSGGNQQKVVLARWLARDPRVLILDEPTRGVD 136

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 170 --------AILReEMRLElmdivhsiGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03215  137 vgakaeiyRLIR-ELADA--------GKAVLLISSELDELLGLCDRILVMYEGRI 182

TagH

COG1134

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate ...

2-225

2.47e-20

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440749 [Multi-domain] Cd Length: 245 Bit Score: 88.21 E-value: 2.47e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmyssakKIK---TSPH 78
Cdd:COG1134   26 ELLLRRRRTRREEFWALKDVSFEVERGESVGIIGRNGAGKSTLLKLIAGILEPTSGRV------------EVNgrvSALL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ErnIGMVFQdfalwPHMNVFENVAFGLRA----TKQTNQLREKV------EDAIKR-VrlqgmeKRYphelSGGQQQRVA 147
Cdd:COG1134   94 E--LGAGFH-----PELTGRENIYLNGRLlglsRKEIDEKFDEIvefaelGDFIDQpV------KTY----SSGMRARLA 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG1134  157 FAVATAVDPDILLVDEVLAVGDAAFQKKCLARIRELRES-GRTVIFVSHSMGAVRRLCDRAIWLEKGRLVMDGDPEEV 233

Uup

COG0488

ATPase components of ABC transporters with duplicated ATPase domains [General function ...

5-197

3.74e-20

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 90.89 E-value: 3.74e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   5 ISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmySSAKKIKtsphernIGM 84
Cdd:COG0488    1 LENLSKSFGGRPLLDDVSLSINPGDRIGLVGRNGAGKSTLLKILAGELEPDSGEV--------SIPKGLR-------IGY 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VFQDFALWPHMNVFENVAFGLRATKQTNQLREKVEDAIK--------------------------RVR--LQGME-KRYP 135
Cdd:COG0488   66 LPQEPPLDDDLTVLDTVLDGDAELRALEAELEELEAKLAepdedlerlaelqeefealggweaeaRAEeiLSGLGfPEED 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 136 H-----ELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilreEMRLELMDIVHSIGLTALYVTHD 197
Cdd:COG0488  146 LdrpvsELSGGWRRRVALARALLSEPDLLLLDEPTNHLDL----ESIEWLEEFLKNYPGTVLVVSHD 208

Uup

COG0488

ATPase components of ABC transporters with duplicated ATPase domains [General function ...

3-216

4.35e-20

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 90.51 E-value: 4.35e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCmyssakkiktspherNI 82
Cdd:COG0488  316 LELEGLSKSYGDKTLLDDLSLRIDRGDRIGLIGPNGAGKSTLLKLLAGELEPDSGTVKLGETV---------------KI 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFA-LWPHMNVFENVAFGLRATKQTnQLREKV-------EDAIKRVRlqgmekryphELSGGQQQRVAFARAIVT 154
Cdd:COG0488  381 GYFDQHQEeLDPDKTVLDELRDGAPGGTEQ-EVRGYLgrflfsgDDAFKPVG----------VLSGGEKARLALAKLLLS 449

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 155 KPHFILFDEPLSALDAilreEMRLELMDivhsiGL-----TALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG0488  450 PPNVLLLDEPTNHLDI----ETLEALEE-----ALddfpgTVLLVSHDRYFLDRVATRILEFEDGGV 507

PRK11174

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

15-221

5.27e-20

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 90.67 E-value: 5.27e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEePDKGEIyfgdtcmyssakKI-----KTSPHE---RNIGMVF 86
Cdd:PRK11174 363 KTLAGPLNFTLPAGQRIALVGPSGAGKTSLLNALLGFL-PYQGSL------------KIngielRELDPEswrKHLSWVG 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  87 QDFALwPHMNVFENVAFGlratkQTNQLREKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTK 155
Cdd:PRK11174 430 QNPQL-PHGTLRDNVLLG-----NPDASDEQLQQALENAWVSEFLPLLPQgldtpigdqaaGLSVGQAQRLALARALLQP 503

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIvhSIGLTALYVTH--DQTEAMsmsDQIIVMKQGEVLQKGT 221
Cdd:PRK11174 504 CQLLLLDEPTASLDAHSEQLVMQALNAA--SRRQTTLMVTHqlEDLAQW---DQIWVMQDGQIVQQGD 566

type_I_sec_HlyB

TIGR01846

type I secretion system ABC transporter, HlyB family; Type I protein secretion is a system in ...

18-225

5.74e-20

type I secretion system ABC transporter, HlyB family; Type I protein secretion is a system in some Gram-negative bacteria to export proteins (often proteases) across both inner and outer membranes to the extracellular medium. This is one of three proteins of the type I secretion apparatus. Targeted proteins are not cleaved at the N-terminus, but rather carry signals located toward the extreme C-terminus to direct type I secretion. [Protein fate, Protein and peptide secretion and trafficking]

Pssm-ID: 273831 [Multi-domain] Cd Length: 694 Bit Score: 90.57 E-value: 5.74e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcMYSSAKKIKTSPH--ERNIGMVFQDFALWPHm 95
Cdd:TIGR01846 473 LSNLNLDIKPGEFIGIVGPSGSGKSTLTKLLQRLYTPQHGQV------LVDGVDLAIADPAwlRRQMGVVLQENVLFSR- 545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   96 NVFENVAFGLRATKqtnqlrekVEDAIKRVRLQGMEK---RYPH-----------ELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:TIGR01846 546 SIRDNIALCNPGAP--------FEHVIHAAKLAGAHDfisELPQgyntevgekgaNLSGGQRQRIAIARALVGNPRILIF 617

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968  162 DEPLSALDAilreEMRLELMDIVHSI--GLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:TIGR01846 618 DEATSALDY----ESEALIMRNMREIcrGRTVIIIAH-RLSTVRACDRIIVLEKGQIAESGRHEEL 678

ABCG_White

cd03234

White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ...

10-220

6.34e-20

White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners.

Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 86.56 E-value: 6.34e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  10 KNFGKT-QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDK---GEIYFGdtcmySSAKKIKTSPheRNIGMV 85
Cdd:cd03234   14 KNWNKYaRILNDVSLHVESGQVMAILGSSGSGKTTLLDAISGRVEGGGttsGQILFN-----GQPRKPDQFQ--KCVAYV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDFALWPHMNVFENVAF----GLRATKQTNQLREKVED------AIKRVRLQGMEKrypheLSGGQQQRVAFARAIVTK 155
Cdd:cd03234   87 RQDDILLPGLTVRETLTYtailRLPRKSSDAIRKKRVEDvllrdlALTRIGGNLVKG-----ISGGERRRVSIAVQLLWD 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 156 PHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:cd03234  162 PKVLILDEPTSGLDSFTALNLVSTLSQLARRNRIVILTIHQPRSDLFRLFDRILLLSSGEIVYSG 226

3a01204

TIGR00955

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ...

24-223

1.04e-19

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273361 [Multi-domain] Cd Length: 617 Bit Score: 89.72 E-value: 1.04e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   24 VMKQGEFTTLLGPSGCGKTTLLRMIAGLEEpdKGEIYFGDTCMysSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAF 103
Cdd:TIGR00955  47 VAKPGELLAVMGSSGAGKTTLMNALAFRSP--KGVKGSGSVLL--NGMPIDAKEMRAISAYVQQDDLFIPTLTVREHLMF 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  104 G--LRATKQT--NQLREKVEDAIKRVRLQ-------GMEKRYpHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAIL 172
Cdd:TIGR00955 123 QahLRMPRRVtkKEKRERVDEVLQALGLRkcantriGVPGRV-KGLSGGERKRLAFASELLTDPPLLFCDEPTSGLDSFM 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446273968  173 REEMRLELMDIVHSiGLTALYVTHDQT-EAMSMSDQIIVMKQGEVLQKGTPE 223
Cdd:TIGR00955 202 AYSVVQVLKGLAQK-GKTIICTIHQPSsELFELFDKIILMAEGRVAYLGSPD 252

MglA

COG1129

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

38-216

3.38e-19

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 87.77 E-value: 3.38e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  38 GCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIK-TSPHE--RN-IGMVFQD---FALWPHMNVFENVA-------- 102
Cdd:COG1129  288 GAGRTELARALFGADPADSGEIRLDG-------KPVRiRSPRDaiRAgIAYVPEDrkgEGLVLDLSIRENITlasldrls 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 103 -FGLRatkQTNQLREKVEDAIKRVRLqgmekRYPH------ELSGGQQQRVAFARAIVTKPHFILFDEPLSALD--Ailr 173
Cdd:COG1129  361 rGGLL---DRRRERALAEEYIKRLRI-----KTPSpeqpvgNLSGGNQQKVVLAKWLATDPKVLILDEPTRGIDvgA--- 429

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446273968 174 eemRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG1129  430 ---KAEIYRLIRELaaeGKAVIVISSELPELLGLSDRILVMREGRI 472

xylG

TIGR02633

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ...

3-215

5.26e-19

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose isomerase and xylulokinase enzymes for xylose utilization. Members of this protein family are the ATP-binding cassette (ABC) subunit of the known or predicted high-affinity xylose ABC transporter for xylose import. These genes, which closely resemble other sugar transport ABC transporter genes, typically are encoded near xylose utilization enzymes and regulatory proteins. Note that this form of the transporter contains two copies of the ABC transporter domain (pfam00005). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 87.57 E-value: 5.26e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD--KGEIYFGDTCMysSAKKIKTSpHER 80
Cdd:TIGR02633   2 LEMKGIVKTFGGVKALDGIDLEVRPGECVGLCGENGAGKSTLMKILSGVYPHGtwDGEIYWSGSPL--KASNIRDT-ERA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   81 NIGMVFQDFALWPHMNVFENVAFGLRAT-----KQTNQLREKVEDAIKRVRLQGMEKRYP-HELSGGQQQRVAFARAIVT 154
Cdd:TIGR02633  79 GIVIIHQELTLVPELSVAENIFLGNEITlpggrMAYNAMYLRAKNLLRELQLDADNVTRPvGDYGGGQQQLVEIAKALNK 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968  155 KPHFILFDEPLSALDailREEMRLeLMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:TIGR02633 159 QARLLILDEPSSSLT---EKETEI-LLDIIRDLkahGVACVYISHKLNEVKAVCDTICVIRDGQ 218

BtuD

COG4138

ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism]; ...

18-225

7.95e-19

ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism];

Pssm-ID: 443313 [Multi-domain] Cd Length: 248 Bit Score: 84.12 E-value: 7.95e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEePDKGEIYFGDTCMySSAkkiktSPHE--RNIGMVFQDFALWPHM 95
Cdd:COG4138   12 LGPISAQVNAGELIHLIGPNGAGKSTLLARMAGLL-PGQGEILLNGRPL-SDW-----SAAElaRHRAYLSQQQSPPFAM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFENVAFGLRATKQTnqlrEKVEDAIKRV--RLQGMEK--RYPHELSGGQQQRVAFARAIV-----TKPH--FILFDEP 164
Cdd:COG4138   85 PVFQYLALHQPAGASS----EAVEQLLAQLaeALGLEDKlsRPLTQLSGGEWQRVRLAAVLLqvwptINPEgqLLLLDEP 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 165 L--------SALDAILREemrlelmdiVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4138  161 MnsldvaqqAALDRLLRE---------LCQQGITVVMSSHDLNHTLRHADRVWLLKQGKLVASGETAEV 220

ABC_KpsT_Wzt

cd03220

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ...

1-216

8.39e-19

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.

Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 83.35 E-value: 8.39e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   1 MDIKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmySSAKKIkTSPHER 80
Cdd:cd03220   21 KKLGILGRKGEVGEFWALKDVSFEVPRGERIGLIGRNGAGKSTLLRLLAGIYPPDSGTV--------TVRGRV-SSLLGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVfqdfalwPHMNVFENVAFGLRATKQTNQLREKVEDAI-----------KRVRlqgmekryphELSGGQQQRVAFA 149
Cdd:cd03220   92 GGGFN-------PELTGRENIYLNGRLLGLSRKEIDEKIDEIiefselgdfidLPVK----------TYSSGMKARLAFA 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 150 RAIVTKPHFILFDEPLSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:cd03220  155 IATALEPDILLIDEVLAVGDAAFQEKC-QRRLRELLKQGKTVILVSHDPSSIKRLCDRALVLEKGKI 220

dppD

PRK11022

dipeptide transporter ATP-binding subunit; Provisional

27-233

9.35e-19

dipeptide transporter ATP-binding subunit; Provisional

Pssm-ID: 182906 [Multi-domain] Cd Length: 326 Bit Score: 85.18 E-value: 9.35e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  27 QGEFTTLLGPSGCGKTTLLRMIAGL-EEPDKgeiYFGDTCMYSSAKKIKTSPHER------NIGMVFQD--FALWPHMNV 97
Cdd:PRK11022  32 QGEVVGIVGESGSGKSVSSLAIMGLiDYPGR---VMAEKLEFNGQDLQRISEKERrnlvgaEVAMIFQDpmTSLNPCYTV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVAFGLRaTKQTNQLREKVEDAIKRVRLQGM---EKR---YPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAI 171
Cdd:PRK11022 109 GFQIMEAIK-VHQGGNKKTRRQRAIDLLNQVGIpdpASRldvYPHQLSGGMSQRVMIAMAIACRPKLLIADEPTTALDVT 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 172 LREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PRK11022 188 IQAQIIELLLELQQKENMALVLITHDLALVAEAAHKIIVMYAGQVVETGKAHDIFRAPRHPY 249

PRK03695

vitamin B12-transporter ATPase; Provisional

18-225

1.53e-18

vitamin B12-transporter ATPase; Provisional

Pssm-ID: 235150 [Multi-domain] Cd Length: 248 Bit Score: 83.44 E-value: 1.53e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLeEPDKGEIYFGDTCM--YSSAKKiktsPHERniGMVFQDFALWPHM 95
Cdd:PRK03695  12 LGPLSAEVRAGEILHLVGPNGAGKSTLLARMAGL-LPGSGSIQFAGQPLeaWSAAEL----ARHR--AYLSQQQTPPFAM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 NVFENVAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAI-----VTKPH--FILFDEPLS-- 166
Cdd:PRK03695  85 PVFQYLTLHQPDKTRTEAVASALNEVAEALGLDDKLGRSVNQLSGGEWQRVRLAAVVlqvwpDINPAgqLLLLDEPMNsl 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 167 ------ALDAILREEMRLelmdivhsiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK03695 165 dvaqqaALDRLLSELCQQ---------GIAVVMSSHDLNHTLRHADRVWLLKQGKLLASGRRDEV 220

PRK15134

microcin C ABC transporter ATP-binding protein YejF; Provisional

28-233

5.15e-18

microcin C ABC transporter ATP-binding protein YejF; Provisional

Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 84.76 E-value: 5.15e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKT-TLLRMIAGLEEPD----KGEIYF-GDTCMYSSAKKIKtspHER--NIGMVFQD--FALWPHMNV 97
Cdd:PRK15134  35 GETLALVGESGSGKSvTALSILRLLPSPPvvypSGDIRFhGESLLHASEQTLR---GVRgnKIAMIFQEpmVSLNPLHTL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVA--FGLRATKQTNQLREKVEDAIKRVRLQGMEKR---YPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAIL 172
Cdd:PRK15134 112 EKQLYevLSLHRGMRREAARGEILNCLDRVGIRQAAKRltdYPHQLSGGERQRVMIAMALLTRPELLIADEPTTALDVSV 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 173 REEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PRK15134 192 QAQILQLLRELQQELNMGLLFITHNLSIVRKLADRVAVMQNGRCVEQNRAATLFSAPTHPY 252

PRK13549

xylose transporter ATP-binding subunit; Provisional

7-215

1.60e-17

xylose transporter ATP-binding subunit; Provisional

Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 83.05 E-value: 1.60e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   7 GLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEePD---KGEIYF-GDTCmysSAKKIKTSpHERNI 82
Cdd:PRK13549  10 NITKTFGGVKALDNVSLKVRAGEIVSLCGENGAGKSTLMKVLSGVY-PHgtyEGEIIFeGEEL---QASNIRDT-ERAGI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFG---------------LRATKQTNQLREKVEDAIKrVRlqgmekryphELSGGQQQRVA 147
Cdd:PRK13549  85 AIIHQELALVKELSVLENIFLGneitpggimdydamyLRAQKLLAQLKLDINPATP-VG----------NLGLGQQQLVE 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAilrEEMRLeLMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:PRK13549 154 IAKALNKQARLLILDEPTASLTE---SETAV-LLDIIRDLkahGIACIYISHKLNEVKAISDTICVIRDGR 220

PRK15439

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

3-225

2.29e-17

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 82.41 E-value: 2.29e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcMYSSAKKIKTspHERNI 82
Cdd:PRK15439  12 LCARSISKQYSGVEVLKGIDFTLHAGEVHALLGGNGAGKSTLMKIIAGIVPPDSGTLEIGGN-PCARLTPAKA--HQLGI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQDFALWPHMNVFENVAFGLRATKQTnqlREKVEDAIKRVRLQgmekRYPHELSG----GQQQRVAFARAIVTKPHF 158
Cdd:PRK15439  89 YLVPQEPLLFPNLSVKENILFGLPKRQAS---MQKMKQLLAALGCQ----LDLDSSAGslevADRQIVEILRGLMRDSRI 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 159 ILFDEPLSALDAIlrEEMRL-----ELMDIVHSIgltaLYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:PRK15439 162 LILDEPTASLTPA--ETERLfsrirELLAQGVGI----VFISHKLPEIRQLADRISVMRDGTIALSGKTADL 227

rim_protein

TIGR01257

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ...

17-222

3.10e-17

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other]

Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 82.75 E-value: 3.10e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSphernIGMVFQDFALWPHMN 96
Cdd:TIGR01257  945 AVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGKDIETNLDAVRQS-----LGMCPQHNILFHHLT 1019

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    97 VFENVAFGLRAT-KQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREE 175
Cdd:TIGR01257 1020 VAEHILFYAQLKgRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVVLDEPTSGVDPYSRRS 1099

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 446273968   176 MRLELMDivHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTP 222
Cdd:TIGR01257 1100 IWDLLLK--YRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTP 1144

araG

PRK11288

L-arabinose ABC transporter ATP-binding protein AraG;

7-214

3.13e-17

L-arabinose ABC transporter ATP-binding protein AraG;

Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 82.27 E-value: 3.13e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   7 GLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCM-YSSAkkikTSPHERNIGMV 85
Cdd:PRK11288   9 GIGKTFPGVKALDDISFDCRAGQVHALMGENGAGKSTLLKILSGNYQPDAGSILIDGQEMrFAST----TAALAAGVAII 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDFALWPHMNVFENVAFGlratkqtnQLREK-----VEDAIKRVRLQ----GMEKRyPH----ELSGGQQQRVAFARAI 152
Cdd:PRK11288  85 YQELHLVPEMTVAENLYLG--------QLPHKggivnRRLLNYEAREQlehlGVDID-PDtplkYLSIGQRQMVEIAKAL 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 153 VTKPHFILFDEPLSALDAilREEMRleLMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:PRK11288 156 ARNARVIAFDEPTSSLSA--REIEQ--LFRVIRELraeGRVILYVSHRMEEIFALCDAITVFKDG 216

ABCF_EF-3

cd03221

ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is ...

3-215

3.93e-17

ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP nucleotide binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.

Pssm-ID: 213188 [Multi-domain] Cd Length: 144 Bit Score: 76.72 E-value: 3.93e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmyssakkikTSPHERNI 82
Cdd:cd03221    1 IELENLSKTYGGKLLLKDISLTINPGDRIGLVGRNGAGKSTLLKLIAGELEPDEGIV---------------TWGSTVKI 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  83 GMVFQdfalwphmnvfenvafglratkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFD 162
Cdd:cd03221   66 GYFEQ--------------------------------------------------LSGGEKMRLALAKLLLENPNLLLLD 95

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446273968 163 EPLSALDailrEEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:cd03221   96 EPTNHLD----LESIEALEEALKEYPGTVILVSHDRYFLDQVATKIIELEDGK 144

ABCG_PDR_domain1

cd03233

First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette ...

9-216

4.76e-17

First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213200 [Multi-domain] Cd Length: 202 Bit Score: 78.07 E-value: 4.76e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   9 EKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD---KGEIYFGDTcmysSAKKIKtSPHERNIGMV 85
Cdd:cd03233   14 GKGRSKIPILKDFSGVVKPGEMVLVLGRPGSGCSTLLKALANRTEGNvsvEGDIHYNGI----PYKEFA-EKYPGEIIYV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDFALWPHMNVFENVAFGLRAtkQTNQLrekvedaikrVRlqgmekryphELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:cd03233   89 SEEDVHFPTLTVRETLDFALRC--KGNEF----------VR----------GISGGERKRVSIAEALVSRASVLCWDNST 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446273968 166 SALDAILREEMRLELMDIVHSIGLTALyVTHDQT--EAMSMSDQIIVMKQGEV 216
Cdd:cd03233  147 RGLDSSTALEILKCIRTMADVLKTTTF-VSLYQAsdEIYDLFDKVLVLYEGRQ 198

PhnL

COG4778

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion ...

3-214

8.68e-17

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism];

Pssm-ID: 443809 [Multi-domain] Cd Length: 229 Bit Score: 77.86 E-value: 8.68e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNF------GKT-QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmYSSAKKI-- 73
Cdd:COG4778    5 LEVENLSKTFtlhlqgGKRlPVLDGVSFSVAAGECVALTGPSGAGKSTLLKCIYGNYLPDSGSILV-----RHDGGWVdl 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  74 -KTSPHE------RNIGMVFQdF--------ALwphmnvfENVAFGLRAT-KQTNQLREKVEDAIKRVRLQgmEKR---Y 134
Cdd:COG4778   80 aQASPREilalrrRTIGYVSQ-FlrviprvsAL-------DVVAEPLLERgVDREEARARARELLARLNLP--ERLwdlP 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 135 PHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILRE---EMRLELMDivhsIGLTALYVTHDqTEAMS-MSDQIIV 210
Cdd:COG4778  150 PATFSGGEQQRVNIARGFIADPPLLLLDEPTASLDAANRAvvvELIEEAKA----RGTAIIGIFHD-EEVREaVADRVVD 224


                 ....
gi 446273968 211 MKQG 214
Cdd:COG4778  225 VTPF 228

PRK13657

glucan ABC transporter ATP-binding protein/ permease;

13-221

1.19e-16

glucan ABC transporter ATP-binding protein/ permease;

Pssm-ID: 184214 [Multi-domain] Cd Length: 588 Bit Score: 80.39 E-value: 1.19e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDfALW 92
Cdd:PRK13657 346 NSRQGVEDVSFEAKPGQTVAIVGPTGAGKSTLINLLQRVFDPQSGRILIDGT----DIRTVTRASLRRNIAVVFQD-AGL 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHMNVFENVAFGlratkQTNQLREKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILF 161
Cdd:PRK13657 421 FNRSIEDNIRVG-----RPDATDEEMRAAAERAQAHDFIERKPDgydtvvgergrQLSGGERQRLAIARALLKDPPILIL 495

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 162 DEPLSALDAILREEMRLELMDIVHsiGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGT 221
Cdd:PRK13657 496 DEATSALDVETEAKVKAALDELMK--GRTTFIIAH-RLSTVRNADRILVFDNGRVVESGS 552

SapD

COG4170

ABC-type antimicrobial peptide export system, ATPase component SapD [Defense mechanisms];

13-231

3.77e-16

ABC-type antimicrobial peptide export system, ATPase component SapD [Defense mechanisms];

Pssm-ID: 443330 [Multi-domain] Cd Length: 331 Bit Score: 78.02 E-value: 3.77e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDkgEIYFGDTCMYSSAKKIKTSPHER------NIGMVF 86
Cdd:COG4170   18 GRVKAVDRVSLTLNEGEIRGLVGESGSGKSLIAKAICGITKDN--WHVTADRFRWNGIDLLKLSPRERrkiigrEIAMIF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  87 QD--FALWPHMNVFENVAFGLRATKQT----NQLREKVEDAIK---RVRLQGME---KRYPHELSGGQQQRVAFARAIVT 154
Cdd:COG4170   96 QEpsSCLDPSAKIGDQLIEAIPSWTFKgkwwQRFKWRKKRAIEllhRVGIKDHKdimNSYPHELTEGECQKVMIAMAIAN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 155 KPHFILFDEPLSALDA-----ILReemRLELMDIVHsiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:COG4170  176 QPRLLIADEPTNAMESttqaqIFR---LLARLNQLQ--GTSILLISHDLESISQWADTITVLYCGQTVESGPTEQILKSP 250


                 ..
gi 446273968 230 SH 231
Cdd:COG4170  251 HH 252

nikD

PRK10418

nickel transporter ATP-binding protein NikD; Provisional

132-232

5.30e-16

nickel transporter ATP-binding protein NikD; Provisional

Pssm-ID: 236688 [Multi-domain] Cd Length: 254 Bit Score: 76.28 E-value: 5.30e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 132 KRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVM 211
Cdd:PRK10418 135 KLYPFEMSGGMLQRMMIALALLCEAPFIIADEPTTDLDVVAQARILDLLESIVQKRALGMLLVTHDMGVVARLADDVAVM 214

                         90       100
                 ....*....|....*....|.
gi 446273968 212 KQGEVLQKGTPEDIYVKPSHE 232
Cdd:PRK10418 215 SHGRIVEQGDVETLFNAPKHA 235

PRK11160

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

16-221

3.31e-15

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 76.02 E-value: 3.31e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  16 QALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHE---RNIGMVFQDfalw 92
Cdd:PRK11160 354 PVLKGLSLQIKAGEKVALLGRTGCGKSTLLQLLTRAWDPQQGEILLNG-------QPIADYSEAalrQAISVVSQR---- 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHmnVF-----ENVAFglrATKQTNQlrEKVEDAIKRVrlqGMEK----------------RyphELSGGQQQRVAFARA 151
Cdd:PRK11160 423 VH--LFsatlrDNLLL---AAPNASD--EALIEVLQQV---GLEKlleddkglnawlgeggR---QLSGGEQRRLGIARA 489

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968 152 IVTKPHFILFDEPLSALDAIL-REEMRLeLMDivHSIGLTALYVTHDQTEAMSMsDQIIVMKQGEVLQKGT 221
Cdd:PRK11160 490 LLHDAPLLLLDEPTEGLDAETeRQILEL-LAE--HAQNKTVLMITHRLTGLEQF-DRICVMDNGQIIEQGT 556

PLN03211

ABC transporter G-25; Provisional

28-220

4.26e-15

ABC transporter G-25; Provisional

Pssm-ID: 215634 [Multi-domain] Cd Length: 659 Bit Score: 76.07 E-value: 4.26e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKgeiyFGDTCMYSSAKKikTSPHERNIGMVFQDFALWPHMNVFENVAFG--L 105
Cdd:PLN03211  94 GEILAVLGPSGSGKSTLLNALAGRIQGNN----FTGTILANNRKP--TKQILKRTGFVTQDDILYPHLTVRETLVFCslL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 106 RATKQ-TNQLREKV-EDAIKRVRLQGMEK-----RYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRL 178
Cdd:PLN03211 168 RLPKSlTKQEKILVaESVISELGLTKCENtiignSFIRGISGGERKRVSIAHEMLINPSLLILDEPTSGLDATAAYRLVL 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446273968 179 ELMDIVHSiGLTALYVTHD-QTEAMSMSDQIIVMKQGEVLQKG 220
Cdd:PLN03211 248 TLGSLAQK-GKTIVTSMHQpSSRVYQMFDSVLVLSEGRCLFFG 289

hmuV

PRK13547

heme ABC transporter ATP-binding protein;

18-231

5.73e-15

heme ABC transporter ATP-binding protein;

Pssm-ID: 184132 [Multi-domain] Cd Length: 272 Bit Score: 73.71 E-value: 5.73e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAG-LEEP--DKGEIYFGDTCMYSS----------AKKIKTSPHERNIGM 84
Cdd:PRK13547  17 LRDLSLRIEPGRVTALLGRNGAGKSTLLKALAGdLTGGgaPRGARVTGDVTLNGEplaaidaprlARLRAVLPQAAQPAF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VF--QDFAL---WPHMNvfenvafglRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAI------- 152
Cdd:PRK13547  97 AFsaREIVLlgrYPHAR---------RAGALTHRDGEIAWQALALAGATALVGRDVTTLSGGELARVQFARVLaqlwpph 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 153 --VTKPHFILFDEPLSALDaiLREEMRLelMDIVHSIG----LTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIy 226
Cdd:PRK13547 168 daAQPPRYLLLDEPTAALD--LAHQHRL--LDTVRRLArdwnLGVLAIVHDPNLAARHADRIAMLADGAIVAHGAPADV- 242


                 ....*
gi 446273968 227 VKPSH 231
Cdd:PRK13547 243 LTPAH 247

ABCC_SUR1_N

cd03290

ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ...

18-214

5.75e-15

ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.

Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 72.75 E-value: 5.75e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKKIKTSPHERNIGMVFQDFALWpHMNV 97
Cdd:cd03290   17 LSNINIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNKNESEPSFEATRSRNRYSVAYAAQKPWLL-NATV 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVAFGLRATKQtnqlreKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:cd03290   96 EENITFGSPFNKQ------RYKAVTDACSLQPDIDLLPFgdqteigergiNLSGGQRQRICVARALYQNTNIVFLDDPFS 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446273968 167 ALDAILREEMRLE-LMDIVHSIGLTALYVTHdQTEAMSMSDQIIVMKQG 214
Cdd:cd03290  170 ALDIHLSDHLMQEgILKFLQDDKRTLVLVTH-KLQYLPHADWIIAMKDG 217

ABC_ABC_ChvD

TIGR03719

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of ...

3-197

1.00e-14

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of the ABC transporter ATP-binding cassette, but are found outside the common ABC transporter operon structure that features integral membrane permease proteins and substrate-binding proteins encoded next to the ATP-binding cassette (ABC domain) protein. The member protein ChvD from Agrobacterium tumefaciens was identified as both a candidate to interact with VirB8, based on yeast two-hybrid analysis, and as an apparent regulator of VirG. The general function of this protein family is unknown.

Pssm-ID: 274744 [Multi-domain] Cd Length: 552 Bit Score: 74.59 E-value: 1.00e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCmyssakkiktspherNI 82
Cdd:TIGR03719 323 IEAENLTKAFGDKLLIDDLSFKLPPGGIVGVIGPNGAGKSTLFRMITGQEQPDSGTIEIGETV---------------KL 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   83 GMVFQ--DfALWPHMNVFENVAFG---LRATKQTNQLRE-------KVEDAIKRVRlqgmekryphELSGGQQQRVAFAR 150
Cdd:TIGR03719 388 AYVDQsrD-ALDPNKTVWEEISGGldiIKLGKREIPSRAyvgrfnfKGSDQQKKVG----------QLSGGERNRVHLAK 456

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 446273968  151 AIVTKPHFILFDEPLSALDAilrEEMR-LElmDIVHSIGLTALYVTHD 197
Cdd:TIGR03719 457 TLKSGGNVLLLDEPTNDLDV---ETLRaLE--EALLNFAGCAVVISHD 499

PRK10762

D-ribose transporter ATP binding protein; Provisional

3-215

3.10e-14

D-ribose transporter ATP binding protein; Provisional

Pssm-ID: 236755 [Multi-domain] Cd Length: 501 Bit Score: 73.11 E-value: 3.10e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEI-YFGDTCMYSSAKkiktSPHERN 81
Cdd:PRK10762   5 LQLKGIDKAFPGVKALSGAALNVYPGRVMALVGENGAGKSTMMKVLTGIYTRDAGSIlYLGKEVTFNGPK----SSQEAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVFQDFALWPHMNVFENVAFGLRATK-----QTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKP 156
Cdd:PRK10762  81 IGIIHQELNLIPQLTIAENIFLGREFVNrfgriDWKKMYAEADKLLARLNLRFSSDKLVGELSIGEQQMVEIAKVLSFES 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 157 HFILFDEPLSAL-----DAILR--EEMRLELMDIVhsigltalYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:PRK10762 161 KVIIMDEPTDALtdtetESLFRviRELKSQGRGIV--------YISHRLKEIFEICDDVTVFRDGQ 218

MK0520

COG2401

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ...

7-198

3.54e-14

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];

Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 70.76 E-value: 3.54e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   7 GLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEE--PDKGEIyfgdtcmyssakkiktsphernigm 84
Cdd:COG2401   35 GVELRVVERYVLRDLNLEIEPGEIVLIVGASGSGKSTLLRLLAGALKgtPVAGCV------------------------- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VFQDFALWPHMNVFENVAfglratkqtnqLREKVEDAIKRVRLQGME-----KRYPHELSGGQQQRVAFARAIVTKPHFI 159
Cdd:COG2401   90 DVPDNQFGREASLIDAIG-----------RKGDFKDAVELLNAVGLSdavlwLRRFKELSTGQKFRFRLALLLAERPKLL 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 446273968 160 LFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQ 198
Cdd:COG2401  159 VIDEFCSHLDRQTAKRVARNLQKLARRAGITLVVATHHY 197

ABC_RNaseL_inhibitor_domain2

cd03237

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ...

26-210

4.28e-14

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213204 [Multi-domain] Cd Length: 246 Bit Score: 70.90 E-value: 4.28e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEI-YFGDTCMYSSAK-KIKTSPHERNIGM-VFQDFALWPHMNVfenva 102
Cdd:cd03237   23 SESEVIGILGPNGIGKTTFIKMLAGVLKPDEGDIeIELDTVSYKPQYiKADYEGTVRDLLSsITKDFYTHPYFKT----- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 103 fglratkqtnqlrekveDAIKRVRLQGMEKRYPHELSGGQQQRVAFArAIVTKPHFI-LFDEPLSALDAilreEMRLELM 181
Cdd:cd03237   98 -----------------EIAKPLQIEQILDREVPELSGGELQRVAIA-ACLSKDADIyLLDEPSAYLDV----EQRLMAS 155

                        170       180       190
                 ....*....|....*....|....*....|...
gi 446273968 182 DIVHSIGL----TALYVTHDQTEAMSMSDQIIV 210
Cdd:cd03237  156 KVIRRFAEnnekTAFVVEHDIIMIDYLADRLIV 188

cyc_pep_trnsptr

TIGR01194

cyclic peptide transporter; This model describes cyclic peptide transporter in bacteria. ...

17-218

4.61e-14

cyclic peptide transporter; This model describes cyclic peptide transporter in bacteria. Bacteria have elaborate pathways for the production of toxins and secondary metabolites. Many such compounds, including syringomycin and pyoverdine are synthesized on non-ribosomal templates consisting of a multienzyme complex. On several occasions the proteins of the complex and transporter protein are present on the same operon. Often times these compounds cross the biological membrane by specific transporters. Syringomycin is an amphipathic, cylclic lipodepsipeptide when inserted into host causes formation of channels, permeable to variety of cations. On the other hand, pyoverdine is a cyclic octa-peptidyl dihydroxyquinoline, which is efficient in sequestering iron for uptake. [Transport and binding proteins, Amino acids, peptides and amines, Transport and binding proteins, Other]

Pssm-ID: 130262 [Multi-domain] Cd Length: 555 Bit Score: 72.68 E-value: 4.61e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKkiktSPHERNIGMVFQDFALWphmN 96
Cdd:TIGR01194 357 ALGPIDLRIAQGDIVFIVGENGCGKSTLAKLFCGLYIPQEGEILLDGAAVSADSR----DDYRDLFSAIFADFHLF---D 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   97 VFENVAFGLRA-TKQTNQLREKVEDAIKrVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREE 175
Cdd:TIGR01194 430 DLIGPDEGEHAsLDNAQQYLQRLEIADK-VKIEDGGFSTTTALSTGQQKRLALICAWLEDRPILLFDEWAADQDPAFKRF 508

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 446273968  176 MRLELMDIVHSIGLTALYVTHDQtEAMSMSDQIIVMKQGEVLQ 218
Cdd:TIGR01194 509 FYEELLPDLKRQGKTIIIISHDD-QYFELADQIIKLAAGCIVK 550

PRK15056

manganese/iron ABC transporter ATP-binding protein;

17-226

9.15e-14

manganese/iron ABC transporter ATP-binding protein;

Pssm-ID: 185016 [Multi-domain] Cd Length: 272 Bit Score: 70.30 E-value: 9.15e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKK--IKTSPHERNIGMVF----QDFA 90
Cdd:PRK15056  22 ALRDASFTVPGGSIAALVGVNGSGKSTLFKALMGFVRLASGKISILGQPTRQALQKnlVAYVPQSEEVDWSFpvlvEDVV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LwphMNVFENVAFGLRATKQTnqlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDa 170
Cdd:PRK15056 102 M---MGRYGHMGWLRRAKKRD---RQIVTAALARVDMVEFRHRQIGELSGGQKKRVFLARAIAQQGQVILLDEPFTGVD- 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 171 iLREEMRL-ELMDIVHSIGLTALYVTHDQTEAMSMSDqIIVMKQGEVLQKGTPEDIY 226
Cdd:PRK15056 175 -VKTEARIiSLLRELRDEGKTMLVSTHNLGSVTEFCD-YTVMVKGTVLASGPTETTF 229

NupO

COG3845

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ...

4-216

1.78e-13

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 70.83 E-value: 1.78e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLE-KNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkIKTSPHE-RN 81
Cdd:COG3845  259 EVENLSvRDDRGVPALKDVSLEVRAGEILGIAGVAGNGQSELAEALAGLRPPASGSIRLDGEDI------TGLSPRErRR 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  82 IGMVF-----QDFALWPHMNVFENVAFGLRATKQ--------TNQLREKVEDAIKR--VRLQGmekryPHE----LSGGQ 142
Cdd:COG3845  333 LGVAYipedrLGRGLVPDMSVAENLILGRYRRPPfsrggfldRKAIRAFAEELIEEfdVRTPG-----PDTparsLSGGN 407

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 143 QQRVAFARAIVTKPHFILFDEPLSALD--AIlrEEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:COG3845  408 QQKVILARELSRDPKLLIAAQPTRGLDvgAI--EFIHQRLLELRDA-GAAVLLISEDLDEILALSDRIAVMYEGRI 480

PRK13543

heme ABC exporter ATP-binding protein CcmA;

18-169

1.88e-13

heme ABC exporter ATP-binding protein CcmA;

Pssm-ID: 184129 [Multi-domain] Cd Length: 214 Bit Score: 68.34 E-value: 1.88e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKTSPHERNIGMVFQDFALWPHMNV 97
Cdd:PRK13543  27 FGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVESGQIQI-------DGKTATRGDRSRFMAYLGHLPGLKADLST 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968  98 FENVAF--GL--RATKQTNQlrekveDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:PRK13543 100 LENLHFlcGLhgRRAKQMPG------SALAIVGLAGYEDTLVRQLSAGQKKRLALARLWLSPAPLWLLDEPYANLD 169

PTZ00243

ABC transporter; Provisional

18-224

5.12e-13

ABC transporter; Provisional

Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 70.19 E-value: 5.12e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYfgdtcmyssakkiktspHERNIGMVFQDfalwphmnv 97
Cdd:PTZ00243  676 LRDVSVSVPRGKLTVVLGATGSGKSTLLQSLLSQFEISEGRVW-----------------AERSIAYVPQQ--------- 729

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   98 fenvAFGLRATKQTNQL------REKVEDAIKRVRLQ--------GMEKRYPHE---LSGGQQQRVAFARAIVTKPHFIL 160
Cdd:PTZ00243  730 ----AWIMNATVRGNILffdeedAARLADAVRVSQLEadlaqlggGLETEIGEKgvnLSGGQKARVSLARAVYANRDVYL 805

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446273968  161 FDEPLSALDAILREEMRLELMdIVHSIGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPED 224
Cdd:PTZ00243  806 LDDPLSALDAHVGERVVEECF-LGALAGKTRVLATH-QVHVVPRADYVVALGDGRVEFSGSSAD 867

PRK10789

SmdA family multidrug ABC transporter permease/ATP-binding protein;

17-229

6.17e-13

SmdA family multidrug ABC transporter permease/ATP-binding protein;

Pssm-ID: 182732 [Multi-domain] Cd Length: 569 Bit Score: 69.36 E-value: 6.17e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYssakKIKTSPHERNIGMVFQDFALWPHmN 96
Cdd:PRK10789 330 ALENVNFTLKPGQMLGICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLT----KLQLDSWRSRLAVVSQTPFLFSD-T 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 VFENVAFGL-RATKQtnQLRE-----KVEDAIKRVRlQGMEKRYPHE---LSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:PRK10789 405 VANNIALGRpDATQQ--EIEHvarlaSVHDDILRLP-QGYDTEVGERgvmLSGGQKQRISIARALLLNAEILILDDALSA 481

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 168 LDAilREEMRlelmdIVHSI-----GLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKP 229
Cdd:PRK10789 482 VDG--RTEHQ-----ILHNLrqwgeGRTVIISAH-RLSALTEASEILVMQHGHIAQRGNHDQLAQQS 540

SufC

COG0396

Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, ...

4-223

1.02e-12

Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440165 [Multi-domain] Cd Length: 245 Bit Score: 66.63 E-value: 1.02e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   4 KISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLE--EPDKGEIYFGD---TCMyssakkiktSPH 78
Cdd:COG0396    2 EIKNLHVSVEGKEILKGVNLTIKPGEVHAIMGPNGSGKSTLAKVLMGHPkyEVTSGSILLDGediLEL---------SPD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ER---NIGMVFQDFALWPHMNVFEnvaFgLRATKQTN--------QLREKVEDAIKRVRL-QGMEKRYPHE-LSGGQQQR 145
Cdd:COG0396   73 ERaraGIFLAFQYPVEIPGVSVSN---F-LRTALNARrgeelsarEFLKLLKEKMKELGLdEDFLDRYVNEgFSGGEKKR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 146 VAFARAIVTKPHFILFDEPLSALDA----ILRE---EMRLElmdivhsiGLTALYVTH-----DQTEAmsmsDQIIVMKQ 213
Cdd:COG0396  149 NEILQMLLLEPKLAILDETDSGLDIdalrIVAEgvnKLRSP--------DRGILIITHyqrilDYIKP----DFVHVLVD 216

                        250
                 ....*....|
gi 446273968 214 GEVLQKGTPE 223
Cdd:COG0396  217 GRIVKSGGKE 226

PRK15093

peptide ABC transporter ATP-binding protein SapD;

13-233

1.25e-12

peptide ABC transporter ATP-binding protein SapD;

Pssm-ID: 185049 [Multi-domain] Cd Length: 330 Bit Score: 67.52 E-value: 1.25e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEpDKGEIYfGDTCMYSSAKKIKTSPHER------NIGMVF 86
Cdd:PRK15093  18 GWVKAVDRVSMTLTEGEIRGLVGESGSGKSLIAKAICGVTK-DNWRVT-ADRMRFDDIDLLRLSPRERrklvghNVSMIF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  87 QD--FALWPHMNVFENV-------AFGLRATKQTNQLREKVEDAIKRVRLQ---GMEKRYPHELSGGQQQRVAFARAIVT 154
Cdd:PRK15093  96 QEpqSCLDPSERVGRQLmqnipgwTYKGRWWQRFGWRKRRAIELLHRVGIKdhkDAMRSFPYELTEGECQKVMIAIALAN 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 155 KPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PRK15093 176 QPRLLIADEPTNAMEPTTQAQIFRLLTRLNQNNNTTILLISHDLQMLSQWADKINVLYCGQTVETAPSKELVTTPHHPY 254

ABC_ABC_ChvD

TIGR03719

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of ...

33-197

1.50e-12

Pssm-ID: 274744 [Multi-domain] Cd Length: 552 Bit Score: 68.04 E-value: 1.50e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmyssAKKIKtsphernIGMVFQDFALWPHMNVFENVAFGLRATKQT- 111
Cdd:TIGR03719  36 VLGLNGAGKSTLLRIMAGVDKDFNGEARP--------QPGIK-------VGYLPQEPQLDPTKTVRENVEEGVAEIKDAl 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  112 -----------------NQLRE---KVEDAIKRVRLQGMEK---------RYP------HELSGGQQQRVAFARAIVTKP 156
Cdd:TIGR03719 101 drfneisakyaepdadfDKLAAeqaELQEIIDAADAWDLDSqleiamdalRCPpwdadvTKLSGGERRRVALCRLLLSKP 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 446273968  157 HFILFDEPLSALDAilreEMRLELMDIVHSIGLTALYVTHD 197
Cdd:TIGR03719 181 DMLLLDEPTNHLDA----ESVAWLERHLQEYPGTVVAVTHD 217

PRK13540

cytochrome c biogenesis protein CcmA; Provisional

25-169

1.71e-12

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 184127 [Multi-domain] Cd Length: 200 Bit Score: 65.36 E-value: 1.71e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  25 MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmYSSAKKIKTSPHERNIGMVFQDFALWPHMNVFENVAFG 104
Cdd:PRK13540  24 LPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILF-----ERQSIKKDLCTYQKQLCFVGHRSGINPYLTLRENCLYD 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 105 LRATKQTNQLREKVedaikRVRLQGMEKRYP-HELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:PRK13540  99 IHFSPGAVGITELC-----RLFSLEHLIDYPcGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALD 159

PRK10522

multidrug transporter membrane component/ATP-binding component; Provisional

17-215

2.11e-12

multidrug transporter membrane component/ATP-binding component; Provisional

Pssm-ID: 236707 [Multi-domain] Cd Length: 547 Bit Score: 67.69 E-value: 2.11e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcMYSSAKKIktSPHERNIGMVFQDFALWPHM- 95
Cdd:PRK10522 338 SVGPINLTIKRGELLFLIGGNGSGKSTLAMLLTGLYQPQSGEILLDG--KPVTAEQP--EDYRKLFSAVFTDFHLFDQLl 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 --NVFENVAFGLRATKQTNQLREKVEDAIKRVRLQgmekryphELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILR 173
Cdd:PRK10522 414 gpEGKPANPALVEKWLERLKMAHKLELEDGRISNL--------KLSKGQKKRLALLLALAEERDILLLDEWAADQDPHFR 485

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446273968 174 EEMRLELMDIVHSIGLTALYVTHDQtEAMSMSDQIIVMKQGE 215
Cdd:PRK10522 486 REFYQVLLPLLQEMGKTIFAISHDD-HYFIHADRLLEMRNGQ 526

ABCC_MRP_domain2

cd03244

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ...

17-222

2.81e-12

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 65.21 E-value: 2.81e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTT----LLRMIagleEPDKGEIYFGDtcmyssaKKIKTSPHE---RNIGMVFQDf 89
Cdd:cd03244   19 VLKNISFSIKPGEKVGIVGRTGSGKSSlllaLFRLV----ELSSGSILIDG-------VDISKIGLHdlrSRISIIPQD- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  90 alwPHM---NVFENVAFGLRATKqtnqlrEKVEDAIKRVRL----QGMEKRYPHE-------LSGGQQQRVAFARAIVTK 155
Cdd:cd03244   87 ---PVLfsgTIRSNLDPFGEYSD------EELWQALERVGLkefvESLPGGLDTVveeggenLSVGQRQLLCLARALLRK 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 156 PHFILFDEPLSALD--------AILREEMRlelmdivhsiGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTP 222
Cdd:cd03244  158 SKILVLDEATASVDpetdaliqKTIREAFK----------DCTVLTIAH-RLDTIIDSDRILVLDKGRVVEFDSP 221

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

26-225

3.26e-12

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 67.46 E-value: 3.26e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIY-FG---DtcmyssAKKIKTsphERNIGMVFQDFALWPHMNVFENV 101
Cdd:NF033858 290 RRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWlFGqpvD------AGDIAT---RRRVGYMSQAFSLYGELTVRQNL 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 102 A-----FGLRAtkqtNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEM 176
Cdd:NF033858 361 ElharlFHLPA----AEIAARVAEMLERFDLADVADALPDSLPLGIRQRLSLAVAVIHKPELLILDEPTSGVDPVARDMF 436

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446273968 177 -RLeLMDIVHSIGLTALYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDI 225
Cdd:NF033858 437 wRL-LIELSREDGVTIFISTHFMNEAER-CDRISLMHAGRVLASDTPAAL 484

PRK13541

cytochrome c biogenesis protein CcmA; Provisional

21-169

3.45e-12

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 184128 [Multi-domain] Cd Length: 195 Bit Score: 64.51 E-value: 3.45e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  21 LQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYSSAKkiktsPHERNIGmvfQDFALWPHMNVFEN 100
Cdd:PRK13541  19 LSITFLPSAITYIKGANGCGKSSLLRMIAGIMQPSSGNIYYKNCNINNIAK-----PYCTYIG---HNLGLKLEMTVFEN 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 101 VAFGLRATKQTnqlrEKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:PRK13541  91 LKFWSEIYNSA----ETLYAAIHYFKLHDLLDEKCYSLSSGMQKIVAIARLIACQSDLWLLDEVETNLS 155

AAA

smart00382

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

27-215

4.71e-12

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 62.78 E-value: 4.71e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    27 QGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakkiktsphernigmvfqdfalwphmnvfenvafglr 106
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDG------------------------------------------ 38

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   107 atkqtnqlrEKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA-----ILREEMRLELM 181
Cdd:smart00382  39 ---------EDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVLILDEITSLLDAeqealLLLLEELRLLL 109

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 446273968   182 DIVHSIGLTALYVTHDQTEAMSM-----SDQIIVMKQGE 215
Cdd:smart00382 110 LLKSEKNLTVILTTNDEKDLGPAllrrrFDRRIVLLLIL 148

PRK10762

D-ribose transporter ATP binding protein; Provisional

25-216

5.68e-12

D-ribose transporter ATP binding protein; Provisional

Pssm-ID: 236755 [Multi-domain] Cd Length: 501 Bit Score: 66.18 E-value: 5.68e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  25 MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIKT-SPHE--RNiGMVF--QDF---ALWPHMN 96
Cdd:PRK10762 275 LRKGEILGVSGLMGAGRTELMKVLYGALPRTSGYVTL-------DGHEVVTrSPQDglAN-GIVYisEDRkrdGLVLGMS 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 VFENVAF-GLRA-TKQTNQLREK-----VEDAIK--RVRLQGMEKRYpHELSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:PRK10762 347 VKENMSLtALRYfSRAGGSLKHAdeqqaVSDFIRlfNIKTPSMEQAI-GLLSGGNQQKVAIARGLMTRPKVLILDEPTRG 425

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446273968 168 LDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PRK10762 426 VDVGAKKEI-YQLINQFKAEGLSIILVSSEMPEVLGMSDRILVMHEGRI 473

ABC_RNaseL_inhibitor_domain1

cd03236

The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ...

24-211

6.27e-12

The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI s are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLIs have an N-terminal Fe-S domain and two nucleotide binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213203 [Multi-domain] Cd Length: 255 Bit Score: 64.70 E-value: 6.27e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  24 VMKQGEFTTLLGPSGCGKTTLLRMIAGL---------EEPDKGEI--YFGDTCMYSSAKKIKtsphERNIGMVF--QDFA 90
Cdd:cd03236   22 VPREGQVLGLVGPNGIGKSTALKILAGKlkpnlgkfdDPPDWDEIldEFRGSELQNYFTKLL----EGDVKVIVkpQYVD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LWPhmNVFE-NVAFGLRATKQTNQLrekvEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:cd03236   98 LIP--KAVKgKVGELLKKKDERGKL----DELVDQLELRHVLDRNIDQLSGGELQRVAIAAALARDADFYFFDEPSSYLD 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446273968 170 AilreEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVM 211
Cdd:cd03236  172 I----KQRLNAARLIRELaedDNYVLVVEHDLAVLDYLSDYIHCL 212

Rli1

COG1245

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...

25-210

8.71e-12

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];

Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 65.96 E-value: 8.71e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  25 MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmySSAKKIKTSPHErnigmVFQDFalwpHMNVFENVAFG 104
Cdd:COG1245  363 IREGEVLGIVGPNGIGKTTFAKILAGVLKPDEGEV--------DEDLKISYKPQY-----ISPDY----DGTVEEFLRSA 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 105 LRATKQTNQLREKVedaIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilreEMRLELMDIV 184
Cdd:COG1245  426 NTDDFGSSYYKTEI---IKPLGLEKLLDKNVKDLSGGELQRVAIAACLSRDADLYLLDEPSAHLDV----EQRLAVAKAI 498

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446273968 185 HSI----GLTALYVTHDqteaMSM----SDQIIV 210
Cdd:COG1245  499 RRFaenrGKTAMVVDHD----IYLidyiSDRLMV 528

MRP_assoc_pro

TIGR00957

multi drug resistance-associated protein (MRP); This model describes multi drug ...

18-221

9.49e-12

multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other]

Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 66.12 E-value: 9.49e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRmiAGLEEPDKGEiyfGDTCMYSSAKKIktsPHERNIgmvfQDFALWphmnv 97
Cdd:TIGR00957  654 LNGITFSIPEGALVAVVGQVGCGKSSLLS--ALLAEMDKVE---GHVHMKGSVAYV---PQQAWI----QNDSLR----- 716

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    98 fENVAFG-------LRATKQTNQLREKVEDAIKRVRLQGMEKRYphELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA 170
Cdd:TIGR00957  717 -ENILFGkalnekyYQQVLEACALLPDLEILPSGDRTEIGEKGV--NLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDA 793

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446273968   171 ILREEMrleLMDIVHSIGL----TALYVTHDQTeAMSMSDQIIVMKQGEVLQKGT 221
Cdd:TIGR00957  794 HVGKHI---FEHVIGPEGVlknkTRILVTHGIS-YLPQVDVIIVMSGGKISEMGS 844

PRK13409

ribosome biogenesis/translation initiation ATPase RLI;

26-210

1.09e-11

ribosome biogenesis/translation initiation ATPase RLI;

Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 65.60 E-value: 1.09e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMYssakK---IKTSPHERnigmvfqdfalwphmnvfenVA 102
Cdd:PRK13409 363 YEGEVIGIVGPNGIGKTTFAKLLAGVLKPDEGEVDPELKISY----KpqyIKPDYDGT--------------------VE 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 103 FGLRATKQ---TNQLREKVedaIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilreEMRLE 179
Cdd:PRK13409 419 DLLRSITDdlgSSYYKSEI---IKPLQLERLLDKNVKDLSGGELQRVAIAACLSRDADLYLLDEPSAHLDV----EQRLA 491

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446273968 180 LMDIVHSI----GLTALYVTHDQTEAMSMSDQIIV 210
Cdd:PRK13409 492 VAKAIRRIaeerEATALVVDHDIYMIDYISDRLMV 526

ABC_FeS_Assembly

cd03217

ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ...

3-223

2.62e-11

ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet.

Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 61.77 E-value: 2.62e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLE--EPDKGEIYFGDtcmyssaKKIKT-SPHE 79
Cdd:cd03217    1 LEIKDLHVSVGGKEILKGVNLTIKKGEVHALMGPNGSGKSTLAKTIMGHPkyEVTEGEILFKG-------EDITDlPPEE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 R---NIGMVFQDFALWPhmnvfenvafGLratkqtnqlreKVEDAIkrvrlqgmekRYPHE-LSGGQQQRVAFARAIVTK 155
Cdd:cd03217   74 RarlGIFLAFQYPPEIP----------GV-----------KNADFL----------RYVNEgFSGGEKKRNEILQLLLLE 122

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 156 PHFILFDEPLSALDAilrEEMRL--ELMDIVHSIGLTALYVTH-----DQTEAmsmsDQIIVMKQGEVLQKGTPE 223
Cdd:cd03217  123 PDLAILDEPDSGLDI---DALRLvaEVINKLREEGKSVLIITHyqrllDYIKP----DRVHVLYDGRIVKSGDKE 190

COG4586

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

26-225

3.03e-11

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 443643 [Multi-domain] Cd Length: 323 Bit Score: 63.18 E-value: 3.03e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcMYSSAKKIKtspHERNIGMVF-QDFALWPHMNVFENvaFG 104
Cdd:COG4586   46 EPGEIVGFIGPNGAGKSTTIKMLTGILVPTSGEVRVLG--YVPFKRRKE---FARRIGVVFgQRSQLWWDLPAIDS--FR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 105 L----------RATKQTNQLRE--KVEDAIKR-VRlqgmekryphELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAI 171
Cdd:COG4586  119 LlkaiyripdaEYKKRLDELVEllDLGELLDTpVR----------QLSLGQRMRCELAAALLHRPKILFLDEPTIGLDVV 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446273968 172 LREEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDI 225
Cdd:COG4586  189 SKEAIREFLKEYNRERGTTILLTSHDMDDIEALCDRVIVIDHGRIIYDGSLEEL 242

3a01205

TIGR00956

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

2-170

3.99e-11

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 64.36 E-value: 3.99e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968     2 DIKISGleknfGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAglEEPDKGEIYFGDtcMYSSAKKIKTSpHERN 81
Cdd:TIGR00956  768 EVKIKK-----EKRVILNNVDGWVKPGTLTALMGASGAGKTTLLNVLA--ERVTTGVITGGD--RLVNGRPLDSS-FQRS 837

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    82 IGMVFQDFALWPHMNVFENVAFG--LRATKQTNqLREKVEDAIKRVRLQGMEKrY-------PHE-LSGGQQQRVAFARA 151
Cdd:TIGR00956  838 IGYVQQQDLHLPTSTVRESLRFSayLRQPKSVS-KSEKMEYVEEVIKLLEMES-YadavvgvPGEgLNVEQRKRLTIGVE 915

                          170       180
                   ....*....|....*....|
gi 446273968   152 IVTKPHFILF-DEPLSALDA 170
Cdd:TIGR00956  916 LVAKPKLLLFlDEPTSGLDS 935

Rli1

COG1245

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...

26-211

4.69e-11

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];

Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 63.65 E-value: 4.69e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  26 KQGEFTTLLGPSGCGKTTLLRMIAGL---------EEPDKGEI--YFGDTCMYS-----SAKKIKTSpHE----RNIGMV 85
Cdd:COG1245   97 KKGKVTGILGPNGIGKSTALKILSGElkpnlgdydEEPSWDEVlkRFRGTELQDyfkklANGEIKVA-HKpqyvDLIPKV 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  86 FQDfalwphmNVFEnvafglrATKQTNQlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:COG1245  176 FKG-------TVRE-------LLEKVDE-RGKLDELAEKLGLENILDRDISELSGGELQRVAIAAALLRDADFYFFDEPS 240

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446273968 166 SALDaiLREEMRL-----ELMDIVHSIgltaLYVTHDQTEAMSMSDQIIVM 211
Cdd:COG1245  241 SYLD--IYQRLNVarlirELAEEGKYV----LVVEHDLAILDYLADYVHIL 285

PTZ00265

multidrug resistance protein (mdr1); Provisional

19-169

5.90e-11

multidrug resistance protein (mdr1); Provisional

Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 63.51 E-value: 5.90e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   19 KPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmySSAKKIKTSPHERNIGMVFQDFALWPHmNVF 98
Cdd:PTZ00265  402 KDLNFTLTEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIINDS---HNLKDINLKWWRSKIGVVSQDPLLFSN-SIK 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   99 ENVAFGLRATKQ----TNQLRE------------------------------------------------KVEDAIKRVR 126
Cdd:PTZ00265  478 NNIKYSLYSLKDlealSNYYNEdgndsqenknkrnscrakcagdlndmsnttdsneliemrknyqtikdsEVVDVSKKVL 557

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 446273968  127 LQGMEKRYP-----------HELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:PTZ00265  558 IHDFVSALPdkyetlvgsnaSKLSGGQKQRISIARAIIRNPKILILDEATSSLD 611

40850658_otr

NF000106

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

3-228

5.92e-11

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

Pssm-ID: 411078 [Multi-domain] Cd Length: 351 Bit Score: 62.83 E-value: 5.92e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCG--KTTLLRMIAGleePDKGE--IYFGDTCMYSSAKKIKTSPH 78
Cdd:NF000106  14 VEVRGLVKHFGEVKAVDGVDLDVREGTVLGVLGP*GAA**RGALPAHV*G---PDAGRrpWRF*TWCANRRALRRTIG*H 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFAlwPHMNVFenvAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHF 158
Cdd:NF000106  91 RPVR*GRRESFS--GRENLY---MIGR*LDLSRKDARARADELLERFSLTEAAGRAAAKYSGGMRRRLDLAASMIGRPAV 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 159 ILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:NF000106 166 LYLDEPTTGLDPRTRNEVWDEVRSMVRD-GATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDELKTK 234

PTZ00265

multidrug resistance protein (mdr1); Provisional

80-225

6.17e-11

multidrug resistance protein (mdr1); Provisional

Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 63.51 E-value: 6.17e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   80 RNI-GMVFQDFALWpHMNVFENVAFGlratkQTNQLREKVEDAIKRVRLQGMEKRYPHE-----------LSGGQQQRVA 147
Cdd:PTZ00265 1295 RNLfSIVSQEPMLF-NMSIYENIKFG-----KEDATREDVKRACKFAAIDEFIESLPNKydtnvgpygksLSGGQKQRIA 1368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  148 FARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIGLTALYVTHdQTEAMSMSDQIIVM----KQGEVLQ-KGTP 222
Cdd:PTZ00265 1369 IARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKTIITIAH-RIASIKRSDKIVVFnnpdRTGSFVQaHGTH 1447


                  ...
gi 446273968  223 EDI 225
Cdd:PTZ00265 1448 EEL 1450

PLN03130

ABC transporter C family member; Provisional

138-225

6.47e-11

ABC transporter C family member; Provisional

Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 63.60 E-value: 6.47e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  138 LSGGQQQRVAFARAIVTKPHFILFDEPLSALDA---------ILREEMRlelmdivhsiGLTALYVThDQTEAMSMSDQI 208
Cdd:PLN03130  741 ISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAhvgrqvfdkCIKDELR----------GKTRVLVT-NQLHFLSQVDRI 809

                          90
                  ....*....|....*..
gi 446273968  209 IVMKQGEVLQKGTPEDI 225
Cdd:PLN03130  810 ILVHEGMIKEEGTYEEL 826

PRK15064

ABC transporter ATP-binding protein; Provisional

5-224

7.49e-11

ABC transporter ATP-binding protein; Provisional

Pssm-ID: 237894 [Multi-domain] Cd Length: 530 Bit Score: 62.99 E-value: 7.49e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   5 ISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCmyssakkiktspherNIGM 84
Cdd:PRK15064 322 VENLTKGFDNGPLFKNLNLLLEAGERLAIIGENGVGKTTLLRTLVGELEPDSGTVKWSENA---------------NIGY 386

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  85 VFQD----FAlwPHMNVFENVAfGLRATKQTNQLREKV--------EDAIKRVRLqgmekrypheLSGGQQQRVAFARAI 152
Cdd:PRK15064 387 YAQDhaydFE--NDLTLFDWMS-QWRQEGDDEQAVRGTlgrllfsqDDIKKSVKV----------LSGGEKGRMLFGKLM 453

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 153 VTKPHFILFDEPLSALD--AILREEMRLELMDivhsiGlTALYVTHDQTEAMSMSDQIIVMKQGEVLQ-KGTPED 224
Cdd:PRK15064 454 MQKPNVLVMDEPTNHMDmeSIESLNMALEKYE-----G-TLIFVSHDREFVSSLATRIIEITPDGVVDfSGTYEE 522

PRK13409

ribosome biogenesis/translation initiation ATPase RLI;

23-211

1.15e-10

ribosome biogenesis/translation initiation ATPase RLI;

Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 62.52 E-value: 1.15e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  23 IVMKQGEFTTLLGPSGCGKTTLLRMIAGL---------EEPDKGEI--YFGDTCMYS-----SAKKIKTSpheRNIGMVf 86
Cdd:PRK13409  94 PIPKEGKVTGILGPNGIGKTTAVKILSGElipnlgdyeEEPSWDEVlkRFRGTELQNyfkklYNGEIKVV---HKPQYV- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  87 qDFAlwPhmNVFE-NVAFGLRATKQtnqlREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK13409 170 -DLI--P--KVFKgKVRELLKKVDE----RGKLDEVVERLGLENILDRDISELSGGELQRVAIAAALLRDADFYFFDEPT 240

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446273968 166 SALDaiLREemRLELMDIVHSI--GLTALYVTHDQTEAMSMSDQIIVM 211
Cdd:PRK13409 241 SYLD--IRQ--RLNVARLIRELaeGKYVLVVEHDLAVLDYLADNVHIA 284

PRK10982

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

5-215

1.34e-10

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 62.05 E-value: 1.34e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   5 ISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF-GDTCMYSSAKKiktsPHERNIG 83
Cdd:PRK10982   1 MSNISKSFPGVKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKDSGSILFqGKEIDFKSSKE----ALENGIS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  84 MVFQDFALWPHMNVFENVAFGLRATKQTNQLREKVEDAIKRVRLQGMEKRYPHE----LSGGQQQRVAFARAIVTKPHFI 159
Cdd:PRK10982  77 MVHQELNLVLQRSVMDNMWLGRYPTKGMFVDQDKMYRDTKAIFDELDIDIDPRAkvatLSVSQMQMIEIAKAFSYNAKIV 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 160 LFDEPLSALDailrEEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGE 215
Cdd:PRK10982 157 IMDEPTSSLT----EKEVNHLFTIIRKLkerGCGIVYISHKMEEIFQLCDEITILRDGQ 211

PRK10790

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;

30-221

1.54e-10

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;

Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 62.04 E-value: 1.54e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  30 FTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDtcmyssaKKIKTSPHE---RNIGMVFQDFALWPHmNVFENVAFGLR 106
Cdd:PRK10790 369 FVALVGHTGSGKSTLASLLMGYYPLTEGEIRLDG-------RPLSSLSHSvlrQGVAMVQQDPVVLAD-TFLANVTLGRD 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 107 ATKqtnqlrEKVEDAIKRVRLQGMEKRYP-----------HELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREE 175
Cdd:PRK10790 441 ISE------EQVWQALETVQLAELARSLPdglytplgeqgNNLSVGQKQLLALARVLVQTPQILILDEATANIDSGTEQA 514

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446273968 176 MRLELMDIVHSiglTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGT 221
Cdd:PRK10790 515 IQQALAAVREH---TTLVVIAHRLSTIVEADTILVLHRGQAVEQGT 557

ABCC_NFT1

cd03369

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ...

2-222

1.89e-10

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 59.73 E-value: 1.89e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   2 DIKISGLEKNFGK--TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHE 79
Cdd:cd03369    6 EIEVENLSVRYAPdlPPVLKNVSFKVKAGEKIGIVGRTGAGKSTLILALFRFLEAEEGKIEIDGI----DISTIPLEDLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDFALwphmnvfenvafgLRATKQTN------QLREKVEDAIkRVRLQGMEkrypheLSGGQQQRVAFARAIV 153
Cdd:cd03369   82 SSLTIIPQDPTL-------------FSGTIRSNldpfdeYSDEEIYGAL-RVSEGGLN------LSQGQRQLLCLARALL 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 154 TKPHFILFDEPLSAL----DAILREEMRLELMD-----IVHSIGLTALYvthdqteamsmsDQIIVMKQGEVLQKGTP 222
Cdd:cd03369  142 KRPRVLVLDEATASIdyatDALIQKTIREEFTNstiltIAHRLRTIIDY------------DKILVMDAGEVKEYDHP 207

ABCC_CFTR1

cd03291

ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ...

18-239

5.38e-10

ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.

Pssm-ID: 213258 [Multi-domain] Cd Length: 282 Bit Score: 59.49 E-value: 5.38e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGeiyfgdtcmyssakKIKtspHERNIGMVFQDFALWPHmNV 97
Cdd:cd03291   53 LKNINLKIEKGEMLAITGSTGSGKTSLLMLILGELEPSEG--------------KIK---HSGRISFSSQFSWIMPG-TI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVAFGLratkQTNQLREKveDAIKRVRLQGMEKRYPHE-----------LSGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:cd03291  115 KENIIFGV----SYDEYRYK--SVVKACQLEEDITKFPEKdntvlgeggitLSGGQRARISLARAVYKDADLYLLDSPFG 188

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968 167 ALDAILREEM----RLELMdivhsIGLTALYVThDQTEAMSMSDQIIVMKQGEVLQKGT-PEDIYVKPshEFVAKFVG 239
Cdd:cd03291  189 YLDVFTEKEIfescVCKLM-----ANKTRILVT-SKMEHLKKADKILILHEGSSYFYGTfSELQSLRP--DFSSKLMG 258

PLN03073

ABC transporter F family; Provisional

33-216

6.28e-10

ABC transporter F family; Provisional

Pssm-ID: 215558 [Multi-domain] Cd Length: 718 Bit Score: 60.26 E-value: 6.28e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYfgdtcmySSAK-KIKTSPHERNIGMVFQDFALWPHMNVFENV---------- 101
Cdd:PLN03073 540 MVGPNGIGKSTILKLISGELQPSSGTVF-------RSAKvRMAVFSQHHVDGLDLSSNPLLYMMRCFPGVpeqklrahlg 612

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 102 AFGLRATkqtnqlrekvedaikrVRLQGMekrypHELSGGQQQRVAFARAIVTKPHFILFDEPLSALDailreemrlelM 181
Cdd:PLN03073 613 SFGVTGN----------------LALQPM-----YTLSGGQKSRVAFAKITFKKPHILLLDEPSNHLD-----------L 660

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446273968 182 DIVHSI--GLT-----ALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PLN03073 661 DAVEALiqGLVlfqggVLMVSHDEHLISGSVDELWVVSEGKV 702

PRK09700

D-allose ABC transporter ATP-binding protein AlsA;

25-218

8.49e-10

D-allose ABC transporter ATP-binding protein AlsA;

Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 59.80 E-value: 8.49e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  25 MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmysSAKKIK-TSPHER-NIGMVF-----QDFALWPHMNV 97
Cdd:PRK09700 286 VCRGEILGFAGLVGSGRTELMNCLFGVDKRAGGEIRL-------NGKDISpRSPLDAvKKGMAYitesrRDNGFFPNFSI 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  98 FENVA-------------FGLRATKQTNQLREKVEDAIKrVRLQGMEKRYpHELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:PRK09700 359 AQNMAisrslkdggykgaMGLFHEVDEQRTAENQRELLA-LKCHSVNQNI-TELSGGNQQKVLISKWLCCCPEVIIFDEP 436

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446273968 165 LSALDAILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQ 218
Cdd:PRK09700 437 TRGIDVGAKAEI-YKVMRQLADDGKVILMVSSELPEIITVCDRIAVFCEGRLTQ 489

PRK11819

putative ABC transporter ATP-binding protein; Reviewed

35-172

1.21e-09

putative ABC transporter ATP-binding protein; Reviewed

Pssm-ID: 236992 [Multi-domain] Cd Length: 556 Bit Score: 59.36 E-value: 1.21e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  35 GPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmyssakkIKtsphernIGMVFQ--DfALWPHMNVFENVAFGLRATKQTN 112
Cdd:PRK11819 357 GPNGAGKSTLFKMITGQEQPDSGTIKIGET--------VK-------LAYVDQsrD-ALDPNKTVWEEISGGLDIIKVGN 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 113 qlRE------------KVEDAIKRVrlqGMekrypheLSGGQQQRVAFARAIVTKPHFILFDEP--------LSAL-DAI 171
Cdd:PRK11819 421 --REipsrayvgrfnfKGGDQQKKV---GV-------LSGGERNRLHLAKTLKQGGNVLLLDEPtndldvetLRALeEAL 488


                 .
gi 446273968 172 L 172
Cdd:PRK11819 489 L 489

xylG

TIGR02633

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ...

25-216

1.21e-09

Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 59.07 E-value: 1.21e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   25 MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD-KGEIYFGD------TCMYSSAKKIKTSPHERNI-GMVfqdfalwPHMN 96
Cdd:TIGR02633 283 LRRGEILGVAGLVGAGRTELVQALFGAYPGKfEGNVFINGkpvdirNPAQAIRAGIAMVPEDRKRhGIV-------PILG 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   97 VFENVAFG-LRATKQTNQLREKVE-----DAIKRVRLQGMEKRYP-HELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:TIGR02633 356 VGKNITLSvLKSFCFKMRIDAAAElqiigSAIQRLKVKTASPFLPiGRLSGGNQQKAVLAKMLLTNPRVLILDEPTRGVD 435

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 446273968  170 AILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:TIGR02633 436 VGAKYEI-YKLINQLAQEGVAIIVVSSELAEVLGLSDRVLVIGEGKL 481

araG

PRK11288

L-arabinose ABC transporter ATP-binding protein AraG;

20-216

1.72e-09

L-arabinose ABC transporter ATP-binding protein AraG;

Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 58.77 E-value: 1.72e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  20 PLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGdtcmySSAKKIKTSPHERNIGMVF------QDfALWP 93
Cdd:PRK11288 271 PISFSVRAGEIVGLFGLVGAGRSELMKLLYGATRRTAGQVYLD-----GKPIDIRSPRDAIRAGIMLcpedrkAE-GIIP 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  94 HMNVFENVAFGLRATKQTNQ--LREKVEDAIKRVRLQGMEKRYPH------ELSGGQQQRVAFARAIVTKPHFILFDEPL 165
Cdd:PRK11288 345 VHSVADNINISARRHHLRAGclINNRWEAENADRFIRSLNIKTPSreqlimNLSGGNQQKAILGRWLSEDMKVILLDEPT 424

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446273968 166 SALDAILREEmrleLMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PRK11288 425 RGIDVGAKHE----IYNVIYELaaqGVAVLFVSSDLPEVLGVADRIVVMREGRI 474

rim_protein

TIGR01257

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ...

3-228

2.07e-09

Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 58.87 E-value: 2.07e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968     3 IKISGLEKNFGKTQ--ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGleepdkgeiyfgDTCMYSSAKKIKTSPHER 80
Cdd:TIGR01257 1938 LRLNELTKVYSGTSspAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTG------------DTTVTSGDATVAGKSILT 2005

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    81 NIGMVFQDFALWPHMNVFENVAFGLRATKQTNQLR-------EKVED-AIKRVRLQGMEKRYPHELSGGQQQRVAFARAI 152
Cdd:TIGR01257 2006 NISDVHQNMGYCPQFDAIDDLLTGREHLYLYARLRgvpaeeiEKVANwSIQSLGLSLYADRLAGTYSGGNKRKLSTAIAL 2085

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968   153 VTKPHFILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:TIGR01257 2086 IGCPPLVLLDEPTTGMDPQARRMLWNTIVSIIRE-GRAVVLTSHSMEECEALCTRLAIMVKGAFQCLGTIQHLKSK 2160

3a01205

TIGR00956

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

14-249

2.12e-09

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 58.97 E-value: 2.12e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIA----GLEEPDKGEI-------------YFGDTcMYSS------- 69
Cdd:TIGR00956   73 TFDILKPMDGLIKPGELTVVLGRPGSGCSTLLKTIAsntdGFHIGVEGVItydgitpeeikkhYRGDV-VYNAetdvhfp 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    70 ----------AKKIKTsPHERNIGMVFQDFAlwPHMNVFENVAFGLRATKQTnqlreKVEDAIKRvrlqgmekryphELS 139
Cdd:TIGR00956  152 hltvgetldfAARCKT-PQNRPDGVSREEYA--KHIADVYMATYGLSHTRNT-----KVGNDFVR------------GVS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   140 GGQQQRVAFARAIVTKPHFILFDEPLSALDA--------ILReemrlELMDIVHSIGLTALYvtHDQTEAMSMSDQIIVM 211
Cdd:TIGR00956  212 GGERKRVSIAEASLGGAKIQCWDNATRGLDSatalefirALK-----TSANILDTTPLVAIY--QCSQDAYELFDKVIVL 284

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 446273968   212 KQGEVlqkgtpedIYVKPSHEfVAKFVGKANWLVEGKQ 249
Cdd:TIGR00956  285 YEGYQ--------IYFGPADK-AKQYFEKMGFKCPDRQ 313

PRK11176

lipid A ABC transporter ATP-binding protein/permease MsbA;

15-228

4.34e-09

lipid A ABC transporter ATP-binding protein/permease MsbA;

Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 57.72 E-value: 4.34e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgDTCmysSAKKIKTSPHERNIGMVFQDFALWpH 94
Cdd:PRK11176 356 VPALRNINFKIPAGKTVALVGRSGSGKSTIANLLTRFYDIDEGEILL-DGH---DLRDYTLASLRNQVALVSQNVHLF-N 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  95 MNVFENVAFGlrATKQTNqlREKVEDAIKRVRLQGMEKRYPH-----------ELSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:PRK11176 431 DTIANNIAYA--RTEQYS--REQIEEAARMAYAMDFINKMDNgldtvigengvLLSGGQRQRIAIARALLRDSPILILDE 506

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446273968 164 PLSALD-----AILR--EEMRLElmdivhsigLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVK 228
Cdd:PRK11176 507 ATSALDteserAIQAalDELQKN---------RTSLVIAH-RLSTIEKADEILVVEDGEIVERGTHAELLAQ 568

PRK11819

putative ABC transporter ATP-binding protein; Reviewed

33-170

4.68e-09

putative ABC transporter ATP-binding protein; Reviewed

Pssm-ID: 236992 [Multi-domain] Cd Length: 556 Bit Score: 57.44 E-value: 4.68e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmyssAKKIKtsphernIGMVFQDFALWPHMNVFENVAFGLRATKQ-- 110
Cdd:PRK11819  38 VLGLNGAGKSTLLRIMAGVDKEFEGEARP--------APGIK-------VGYLPQEPQLDPEKTVRENVEEGVAEVKAal 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 111 ----------------TNQLRE---KVEDAIKRVRL--------QGMEK-RYPH------ELSGGQQQRVAFARAIVTKP 156
Cdd:PRK11819 103 drfneiyaayaepdadFDALAAeqgELQEIIDAADAwdldsqleIAMDAlRCPPwdakvtKLSGGERRRVALCRLLLEKP 182

                        170
                 ....*....|....
gi 446273968 157 HFILFDEPLSALDA 170
Cdd:PRK11819 183 DMLLLDEPTNHLDA 196

CFTR_protein

TIGR01271

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...

15-221

4.89e-09

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]

Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 57.61 E-value: 4.89e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    15 TQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGeiyfgdtcmyssakKIKtspHERNIGMVFQDFALWPH 94
Cdd:TIGR01271  439 TPVLKNISFKLEKGQLLAVAGSTGSGKSSLLMMIMGELEPSEG--------------KIK---HSGRISFSPQTSWIMPG 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    95 mNVFENVAFGL-------RATKQTNQLREKVEDAIKRVRLQGMEKRYphELSGGQQQRVAFARAIVTKPHFILFDEPLSA 167
Cdd:TIGR01271  502 -TIKDNIIFGLsydeyryTSVIKACQLEEDIALFPEKDKTVLGEGGI--TLSGGQRARISLARAVYKDADLYLLDSPFTH 578

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968   168 LDAILREEM----RLELMdivhsIGLTALYVThDQTEAMSMSDQIIVMKQGEVLQKGT 221
Cdd:TIGR01271  579 LDVVTEKEIfescLCKLM-----SNKTRILVT-SKLEHLKKADKILLLHEGVCYFYGT 630

ABCG_PDR_domain2

cd03232

Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding ...

13-214

6.52e-09

Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213199 [Multi-domain] Cd Length: 192 Bit Score: 54.94 E-value: 6.52e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  13 GKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPD--KGEIYFgdtcmysSAKKIKTSpHERNIGMVFQDFA 90
Cdd:cd03232   18 GKRQLLNNISGYVKPGTLTALMGESGAGKTTLLDVLAGRKTAGviTGEILI-------NGRPLDKN-FQRSTGYVEQQDV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  91 LWPHMNVFENVAFG--LRAtkqtnqlrekvedaikrvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSAL 168
Cdd:cd03232   90 HSPNLTVREALRFSalLRG------------------------------LSVEQRKRLTIGVELAAKPSILFLDEPTSGL 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446273968 169 DAilreEMRLELMDIVHSI---GLTALYVTHDQTEA-MSMSDQIIVMKQG 214
Cdd:cd03232  140 DS----QAAYNIVRFLKKLadsGQAILCTIHQPSASiFEKFDRLLLLKRG 185

PRK11147

ABC transporter ATPase component; Reviewed

3-249

1.18e-08

ABC transporter ATPase component; Reviewed

Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 56.11 E-value: 1.18e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgdtcmyssAKKIKTSPHE--- 79
Cdd:PRK11147   4 ISIHGAWLSFSDAPLLDNAELHIEDNERVCLVGRNGAGKSTLMKILNGEVLLDDGRIIY--------EQDLIVARLQqdp 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 -RNI-GMVFqDFalwphmnVFENVAFGLRATKQTNQLREKVED-----AIKRV-RLQG---------MEKRY-------- 134
Cdd:PRK11147  76 pRNVeGTVY-DF-------VAEGIEEQAEYLKRYHDISHLVETdpsekNLNELaKLQEqldhhnlwqLENRInevlaqlg 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 135 --PH----ELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSIgltaLYVTHDQTEAMSMSDQI 208
Cdd:PRK11147 148 ldPDaalsSLSGGWLRKAALGRALVSNPDVLLLDEPTNHLDIETIEWLEGFLKTFQGSI----IFISHDRSFIRNMATRI 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446273968 209 IVMKQGEVLQKGTPEDIYVkpshefvakfVGKANWL-VEGKQ 249
Cdd:PRK11147 224 VDLDRGKLVSYPGNYDQYL----------LEKEEALrVEELQ 255

GguA

NF040905

sugar ABC transporter ATP-binding protein;

7-214

1.56e-08

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 55.57 E-value: 1.56e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   7 GLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGL------EepdkGEIYF-GDTCMYssaKKIKTSpHE 79
Cdd:NF040905   6 GITKTFPGVKALDDVNLSVREGEIHALCGENGAGKSTLMKVLSGVyphgsyE----GEILFdGEVCRF---KDIRDS-EA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  80 RNIGMVFQDFALWPHMNVFENVAFG-LRATK---QTNQLREKVEDAIKRVRLqgmeKRYPHELSG----GQQQRVAFARA 151
Cdd:NF040905  78 LGIVIIHQELALIPYLSIAENIFLGnERAKRgviDWNETNRRARELLAKVGL----DESPDTLVTdigvGKQQLVEIAKA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446273968 152 IVTKPHFILFDEPLSAL---DAilreEMRLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQG 214
Cdd:NF040905 154 LSKDVKLLILDEPTAALneeDS----AALLDLLLELKAQGITSIIISHKLNEIRRVADSITVLRDG 215

PLN03232

ABC transporter C family member; Provisional

138-226

1.79e-08

ABC transporter C family member; Provisional

Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 56.14 E-value: 1.79e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  138 LSGGQQQRVAFARAIVTKPHFILFDEPLSALDA---------ILREEMRlelmdivhsiGLTALYVThDQTEAMSMSDQI 208
Cdd:PLN03232  741 ISGGQKQRVSMARAVYSNSDIYIFDDPLSALDAhvahqvfdsCMKDELK----------GKTRVLVT-NQLHFLPLMDRI 809

                          90
                  ....*....|....*...
gi 446273968  209 IVMKQGEVLQKGTPEDIY 226
Cdd:PLN03232  810 ILVSEGMIKEEGTFAELS 827

ABC_RNaseL_inhibitor

cd03222

ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a ...

24-210

1.91e-08

ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins, and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains, which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213189 [Multi-domain] Cd Length: 177 Bit Score: 53.34 E-value: 1.91e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  24 VMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYfgdtcmyssakkiktsphernigmvfqdfalWPHMNVfenvaf 103
Cdd:cd03222   21 VVKEGEVIGIVGPNGTGKTTAVKILAGQLIPNGDNDE-------------------------------WDGITP------ 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 104 glratkqtnqlrekvedAIKRVRLqgmekryphELSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilreEMRLELMDI 183
Cdd:cd03222   64 -----------------VYKPQYI---------DLSGGELQRVAIAAALLRNATFYLFDEPSAYLDI----EQRLNAARA 113

                        170       180       190
                 ....*....|....*....|....*....|.
gi 446273968 184 VHSIGL----TALYVTHDQTEAMSMSDQIIV 210
Cdd:cd03222  114 IRRLSEegkkTALVVEHDLAVLDYLSDRIHV 144

PRK15439

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

28-227

2.84e-08

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 55.06 E-value: 2.84e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFG--DTCMYSSAKKIKTS----PHERNIGMVFQDFAL-WphmnvfeN 100
Cdd:PRK15439 289 GEILGLAGVVGAGRTELAETLYGLRPARGGRIMLNgkEINALSTAQRLARGlvylPEDRQSSGLYLDAPLaW-------N 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 101 VAfGLRATKQTNQLREKVEDAI-KRVRlQGMEKRYPHE------LSGGQQQRVAFARAIVTKPHFILFDEPLSALDAilr 173
Cdd:PRK15439 362 VC-ALTHNRRGFWIKPARENAVlERYR-RALNIKFNHAeqaartLSGGNQQKVLIAKCLEASPQLLIVDEPTRGVDV--- 436

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446273968 174 eEMRLELMDIVHSI---GLTALYVTHDQTEAMSMSDQIIVMKQGEVLQKGTPEDIYV 227
Cdd:PRK15439 437 -SARNDIYQLIRSIaaqNVAVLFISSDLEEIEQMADRVLVMHQGEISGALTGAAINV 492

3a01203

TIGR00954

Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, ...

21-185

3.74e-08

Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273360 [Multi-domain] Cd Length: 659 Bit Score: 54.75 E-value: 3.74e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   21 LQIVMKQGEFTTLLGPSGCGKTTLLRMIAGL--------EEPDKGEIYFgdtcmyssakkIKTSPHERNigMVFQDFALW 92
Cdd:TIGR00954 471 LSFEVPSGNNLLICGPNGCGKSSLFRILGELwpvyggrlTKPAKGKLFY-----------VPQRPYMTL--GTLRDQIIY 537

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   93 PhMNVFENVAFGLRATKQTNQLRE-KVEDAIKR-VRLQGMEKrYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSAL-- 168
Cdd:TIGR00954 538 P-DSSEDMKRRGLSDKDLEQILDNvQLTHILEReGGWSAVQD-WMDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVsv 615

                         170       180
                  ....*....|....*....|..
gi 446273968  169 ---DAILR--EEMRLELMDIVH 185
Cdd:TIGR00954 616 dveGYMYRlcREFGITLFSVSH 637

PvdE

COG4615

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion ...

17-216

6.69e-08

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion transport and metabolism];

Pssm-ID: 443659 [Multi-domain] Cd Length: 547 Bit Score: 53.65 E-value: 6.69e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  17 ALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTCMyssakkiktSPHER-----NIGMVFQDFAL 91
Cdd:COG4615  347 TLGPIDLTIRRGELVFIVGGNGSGKSTLAKLLTGLYRPESGEILLDGQPV---------TADNReayrqLFSAVFSDFHL 417

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  92 wphmnvFENVaFGLratkQTNQLREKVEDAIKRVRLQgmekrypH------------ELSGGQQQRVAFARAIVTKPHFI 159
Cdd:COG4615  418 ------FDRL-LGL----DGEADPARARELLERLELD-------HkvsvedgrfsttDLSQGQRKRLALLVALLEDRPIL 479

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968 160 LFDEPLSALDAILRE--------EMRlelmdivhSIGLTALYVTHDQTeAMSMSDQIIVMKQGEV 216
Cdd:COG4615  480 VFDEWAADQDPEFRRvfytellpELK--------ARGKTVIAISHDDR-YFDLADRVLKMDYGKL 535

PLN03140

ABC transporter G family member; Provisional

14-170

3.11e-07

ABC transporter G family member; Provisional

Pssm-ID: 215599 [Multi-domain] Cd Length: 1470 Bit Score: 52.16 E-value: 3.11e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   14 KTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEepdKGEIYFGDTCMYSSAKKIKTspHERNIGMVFQDFALWP 93
Cdd:PLN03140  892 RLQLLREVTGAFRPGVLTALMGVSGAGKTTLMDVLAGRK---TGGYIEGDIRISGFPKKQET--FARISGYCEQNDIHSP 966

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   94 HMNVFENVAFG--LRATKQ---------TNQLREKVE-----DAIkrVRLQGMEKrypheLSGGQQQRVAFARAIVTKPH 157
Cdd:PLN03140  967 QVTVRESLIYSafLRLPKEvskeekmmfVDEVMELVEldnlkDAI--VGLPGVTG-----LSTEQRKRLTIAVELVANPS 1039

                         170
                  ....*....|...
gi 446273968  158 FILFDEPLSALDA 170
Cdd:PLN03140 1040 IIFMDEPTSGLDA 1052

PRK13549

xylose transporter ATP-binding subunit; Provisional

25-216

5.71e-07

xylose transporter ATP-binding subunit; Provisional

Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 50.70 E-value: 5.71e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  25 MKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDK-GEIYFgdtcmysSAKKIKT-SPHE---RNIGMVFQD---FALWPHMN 96
Cdd:PRK13549 285 LRRGEILGIAGLVGAGRTELVQCLFGAYPGRWeGEIFI-------DGKPVKIrNPQQaiaQGIAMVPEDrkrDGIVPVMG 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 VFENVAFG-LRATKQTNQLREKVEDAIKRVRLQGMEKRYPH------ELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:PRK13549 358 VGKNITLAaLDRFTGGSRIDDAAELKTILESIQRLKVKTASpelaiaRLSGGNQQKAVLAKCLLLNPKILILDEPTRGID 437

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446273968 170 AILREEMrLELMDIVHSIGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PRK13549 438 VGAKYEI-YKLINQLVQQGVAIIVISSELPEVLGLSDRVLVMHEGKL 483

PRK10938

putative molybdenum transport ATP-binding protein ModF; Provisional

28-201

8.64e-07

putative molybdenum transport ATP-binding protein ModF; Provisional

Pssm-ID: 182852 [Multi-domain] Cd Length: 490 Bit Score: 50.40 E-value: 8.64e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  28 GEFTTLLGPSGCGKTTLLRMIAGleepDKGEIYFGDTCMYSSAK-------KIKtspheRNIGMVFQDFalwpHM----- 95
Cdd:PRK10938 286 GEHWQIVGPNGAGKSTLLSLITG----DHPQGYSNDLTLFGRRRgsgetiwDIK-----KHIGYVSSSL----HLdyrvs 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  96 ----NV-----FENVafGL-RATkqTNQLREKVEDAIKRVRLQGMEKRYP-HELSGGQQQRVAFARAIVTKPHFILFDEP 164
Cdd:PRK10938 353 tsvrNVilsgfFDSI--GIyQAV--SDRQQKLAQQWLDILGIDKRTADAPfHSLSWGQQRLALIVRALVKHPTLLILDEP 428

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 446273968 165 LSALDAILREEMRlELMDIVHSIGLTAL-YVTHDQTEA 201
Cdd:PRK10938 429 LQGLDPLNRQLVR-RFVDVLISEGETQLlFVSHHAEDA 465

PRK10636

putative ABC transporter ATP-binding protein; Provisional

33-216

1.13e-06

putative ABC transporter ATP-binding protein; Provisional

Pssm-ID: 236729 [Multi-domain] Cd Length: 638 Bit Score: 50.17 E-value: 1.13e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  33 LLGPSGCGKTTLLRMIAGLEEPDKGEIyfgdtcmySSAKKIKT---SPHErnIGMVFQDFALWPHMnvfenVAFGLRATK 109
Cdd:PRK10636 343 LLGRNGAGKSTLIKLLAGELAPVSGEI--------GLAKGIKLgyfAQHQ--LEFLRADESPLQHL-----ARLAPQELE 407

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 110 QtnQLRE----------KVEDAIKRvrlqgmekrypheLSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLE 179
Cdd:PRK10636 408 Q--KLRDylggfgfqgdKVTEETRR-------------FSGGEKARLVLALIVWQRPNLLLLDEPTNHLDLDMRQALTEA 472

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446273968 180 LMDIVHSIgltaLYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PRK10636 473 LIDFEGAL----VVVSHDRHLLRSTTDDLYLVHDGKV 505

PRK11147

ABC transporter ATPase component; Reviewed

8-197

1.59e-06

ABC transporter ATPase component; Reviewed

Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 49.56 E-value: 1.59e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   8 LEKNFGKTqalkplqiVMKqGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGdtcmyssaKKIKTSphernigmVFQ 87
Cdd:PRK11147 334 LVKDFSAQ--------VQR-GDKIALIGPNGCGKTTLLKLMLGQLQADSGRIHCG--------TKLEVA--------YFD 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  88 DF--ALWPHMNVFENVAFGlratKQTnqlrekVE-DAIKR---VRLQG-----MEKRYP-HELSGGQQQRVAFARaIVTK 155
Cdd:PRK11147 389 QHraELDPEKTVMDNLAEG----KQE------VMvNGRPRhvlGYLQDflfhpKRAMTPvKALSGGERNRLLLAR-LFLK 457

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446273968 156 P-HFILFDEPLSALDAilrEEMRLeLMDIVHSIGLTALYVTHD 197
Cdd:PRK11147 458 PsNLLILDEPTNDLDV---ETLEL-LEELLDSYQGTVLLVSHD 496

PLN03232

ABC transporter C family member; Provisional

18-233

8.39e-06

ABC transporter C family member; Provisional

Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 47.66 E-value: 8.39e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFgDTCmysSAKKIKTSPHERNIGMVFQDFALWPHmnv 97
Cdd:PLN03232 1252 LHGLSFFVSPSEKVGVVGRTGAGKSSMLNALFRIVELEKGRIMI-DDC---DVAKFGLTDLRRVLSIIPQSPVLFSG--- 1324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   98 feNVAFGLRATKQTNQlrEKVEDAIKRVRLQGMEKRYPHEL-----------SGGQQQRVAFARAIVTKPHFILFDEPLS 166
Cdd:PLN03232 1325 --TVRFNIDPFSEHND--ADLWEALERAHIKDVIDRNPFGLdaevseggenfSVGQRQLLSLARALLRRSKILVLDEATA 1400

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446273968  167 ALDA--------ILREEMRlelmdivhsiGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PLN03232 1401 SVDVrtdsliqrTIREEFK----------SCTMLVIAH-RLNTIIDCDKILVLSSGQVLEYDSPQELLSRDTSAF 1464

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

3-225

1.46e-05

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 46.66 E-value: 1.46e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYF--GDtcMYSSAKKIKTSPH-- 78
Cdd:NF033858   2 ARLEGVSHRYGKTVALDDVSLDIPAGCMVGLIGPDGVGKSSLLSLIAGARKIQQGRVEVlgGD--MADARHRRAVCPRia 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ------ERNigmvfqdfaLWPHMNVFENVAF-----GLRATkqtnQLREKVEDAIKRVRLQGMEKRYPHELSGGQQQRVA 147
Cdd:NF033858  80 ympqglGKN---------LYPTLSVFENLDFfgrlfGQDAA----ERRRRIDELLRATGLAPFADRPAGKLSGGMKQKLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 148 FARAIVTKPHFILFDEPLSALDAILR-------EEMRLElmdivhSIGLTALYVTHDQTEAMSMsDQIIVMKQGEVLQKG 220
Cdd:NF033858 147 LCCALIHDPDLLILDEPTTGVDPLSRrqfweliDRIRAE------RPGMSVLVATAYMEEAERF-DWLVAMDAGRVLATG 219


                 ....*
gi 446273968 221 TPEDI 225
Cdd:NF033858 220 TPAEL 224

CFTR_protein

TIGR01271

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...

18-219

1.57e-05

Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 46.83 E-value: 1.57e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDkGEIY-----------------FG----DTCMYSSAKKIKTS 76
Cdd:TIGR01271 1235 LQDLSFSVEGGQRVGLLGRTGSGKSTLLSALLRLLSTE-GEIQidgvswnsvtlqtwrkaFGvipqKVFIFSGTFRKNLD 1313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    77 PHERnigmvFQDFALWphmNVFENVafGLRAtkqtnqLREKVEDAIKRVRLQGmekryPHELSGGQQQRVAFARAIVTKP 156
Cdd:TIGR01271 1314 PYEQ-----WSDEEIW---KVAEEV--GLKS------VIEQFPDKLDFVLVDG-----GYVLSNGHKQLMCLARSILSKA 1372

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968   157 HFILFDEPLSALDAILREEMRLELMdivHSIGLTALYVTHDQTEAMSMSDQIIV-----MKQGEVLQK 219
Cdd:TIGR01271 1373 KILLLDEPSAHLDPVTLQIIRKTLK---QSFSNCTVILSEHRVEALLECQQFLViegssVKQYDSIQK 1437

ycf16

CHL00131

sulfate ABC transporter protein; Validated

3-223

2.16e-05

sulfate ABC transporter protein; Validated

Pssm-ID: 214372 [Multi-domain] Cd Length: 252 Bit Score: 45.02 E-value: 2.16e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNFGKTQALKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGleEPD----KGEIYFGDTCMyssakkIKTSPH 78
Cdd:CHL00131   8 LEIKNLHASVNENEILKGLNLSINKGEIHAIMGPNGSGKSTLSKVIAG--HPAykilEGDILFKGESI------LDLEPE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  79 ERNIGMVFQDFALWPHMNVFENVAFgLRATKQTNQ-LREKVE-DAI-------KRVRLQGMEKRYPHE-----LSGGQQQ 144
Cdd:CHL00131  80 ERAHLGIFLAFQYPIEIPGVSNADF-LRLAYNSKRkFQGLPElDPLefleiinEKLKLVGMDPSFLSRnvnegFSGGEKK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 145 RVAFARAIVTKPHFILFDEPLSALD----AILREEMRLeLMDIVHSIgltaLYVTHDQteamSMSDQII-----VMKQGE 215
Cdd:CHL00131 159 RNEILQMALLDSELAILDETDSGLDidalKIIAEGINK-LMTSENSI----ILITHYQ----RLLDYIKpdyvhVMQNGK 229


                 ....*...
gi 446273968 216 VLQKGTPE 223
Cdd:CHL00131 230 IIKTGDAE 237

MRP_assoc_pro

TIGR00957

multi drug resistance-associated protein (MRP); This model describes multi drug ...

18-225

3.15e-05

Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 45.71 E-value: 3.15e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLEEPDKGEIYFGDTcmysSAKKIKTSPHERNIGMVFQDFALWP---H 94
Cdd:TIGR00957 1302 LRHINVTIHGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGL----NIAKIGLHDLRFKITIIPQDPVLFSgslR 1377

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968    95 MNvfenvafgLRATKQTNQlrEKVEDAIKRVRLQGMEKRYP----HE-------LSGGQQQRVAFARAIVTKPHFILFDE 163
Cdd:TIGR00957 1378 MN--------LDPFSQYSD--EEVWWALELAHLKTFVSALPdkldHEcaeggenLSVGQRQLVCLARALLRKTKILVLDE 1447

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446273968   164 PLSALDailreemrLELMDIVHSI------GLTALYVTHDQTEAMSMSdQIIVMKQGEVLQKGTPEDI 225
Cdd:TIGR00957 1448 ATAAVD--------LETDNLIQSTirtqfeDCTVLTIAHRLNTIMDYT-RVIVLDKGEVAEFGAPSNL 1506

PRK00635

excinuclease ABC subunit A; Provisional

138-238

1.46e-04

excinuclease ABC subunit A; Provisional

Pssm-ID: 234806 [Multi-domain] Cd Length: 1809 Bit Score: 43.66 E-value: 1.46e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  138 LSGGQQQRVAFAR---AIVTKPHFILfDEPlsaldAI-LREEMRLELMDIVHSI---GLTALYVTHDQtEAMSMSDQIIV 210
Cdd:PRK00635  477 LSGGEQERTALAKhlgAELIGITYIL-DEP-----SIgLHPQDTHKLINVIKKLrdqGNTVLLVEHDE-QMISLADRIID 549

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446273968  211 MKQ------GEVLQKGTPEDiYVKPSHEFVAKFV 238
Cdd:PRK00635  550 IGPgagifgGEVLFNGSPRE-FLAKSDSLTAKYL 582

uvra

TIGR00630

excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of ...

83-230

2.12e-04

excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of proteins of which all members for which functions are known except the UvrA proteins are involved in the transport of material through membranes. UvrA orthologs are involved in the recognition of DNA damage as a step in nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

Pssm-ID: 273184 [Multi-domain] Cd Length: 925 Bit Score: 43.08 E-value: 2.12e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   83 GMVFQDFALWPhmnVFENVAF--GLRATKQTNQLREKVEDAIKRvRLQ-----GME----KRYPHELSGGQQQRVAFARA 151
Cdd:TIGR00630 427 GKSIADVSELS---IREAHEFfnQLTLTPEEKKIAEEVLKEIRE-RLGflidvGLDylslSRAAGTLSGGEAQRIRLATQ 502

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  152 I---VTKPHFILfDEPLSALDAilREEMRL-ELMDIVHSIGLTALYVTHDQtEAMSMSDQIIVM------KQGEVLQKGT 221
Cdd:TIGR00630 503 IgsgLTGVLYVL-DEPSIGLHQ--RDNRRLiNTLKRLRDLGNTLIVVEHDE-DTIRAADYVIDIgpgageHGGEVVASGT 578


                  ....*....
gi 446273968  222 PEDIYVKPS 230
Cdd:TIGR00630 579 PEEILANPD 587

PTZ00243

ABC transporter; Provisional

139-233

3.07e-04

ABC transporter; Provisional

Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 42.84 E-value: 3.07e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  139 SGGQQQRVAFARAIVTK-PHFILFDEPLSALDAILREEMRLELMD---------IVHSIGLTALYvthdqteamsmsDQI 208
Cdd:PTZ00243 1447 SVGQRQLMCMARALLKKgSGFILMDEATANIDPALDRQIQATVMSafsaytvitIAHRLHTVAQY------------DKI 1514

                          90       100
                  ....*....|....*....|....*
gi 446273968  209 IVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:PTZ00243 1515 IVMDHGAVAEMGSPRELVMNRQSIF 1539

PRK10982

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

138-216

3.75e-04

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 42.02 E-value: 3.75e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446273968 138 LSGGQQQRVAFARAIVTKPHFILFDEPLSALDAILREEMRLELMDIVHSiGLTALYVTHDQTEAMSMSDQIIVMKQGEV 216
Cdd:PRK10982 392 LSGGNQQKVIIGRWLLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKK-DKGIIIISSEMPELLGITDRILVMSNGLV 469

SbcC

COG0419

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];

31-197

5.75e-04

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];

Pssm-ID: 440188 [Multi-domain] Cd Length: 204 Bit Score: 40.38 E-value: 5.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  31 TTLLGPSGCGKTTLLRMIA-GLEEPDKGEIYFGDTCMYSSAKKIKtsphernIGMVFQ-------------DFALWPHMN 96
Cdd:COG0419   26 NLIVGPNGAGKSTILEAIRyALYGKARSRSKLRSDLINVGSEEAS-------VELEFEhggkryrierrqgEFAEFLEAK 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  97 ------VFENVaFGL----RATKQTNQLREKVEDAIKRV-RLQGMEKRY---------PHELSGGQQQRVAFARAIVtkp 156
Cdd:COG0419   99 pserkeALKRL-LGLeiyeELKERLKELEEALESALEELaELQKLKQEIlaqlsgldpIETLSGGERLRLALADLLS--- 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 446273968 157 hfILFDepLSALDailrEEMRLELMDIVHSIGLtalyVTHD 197
Cdd:COG0419  175 --LILD--FGSLD----EERLERLLDALEELAI----ITHV 203

PLN03130

ABC transporter C family member; Provisional

33-242

5.95e-04

ABC transporter C family member; Provisional

Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 41.65 E-value: 5.95e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   33 LLGPSGCGKTTLLRMIAGLEEPDKGEIYFgDTCMYSsakKIKTSPHERNIGMVFQDFALWPHmnvfeNVAFGLRATKQTN 112
Cdd:PLN03130 1270 IVGRTGAGKSSMLNALFRIVELERGRILI-DGCDIS---KFGLMDLRKVLGIIPQAPVLFSG-----TVRFNLDPFNEHN 1340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  113 --QLREKVE-----DAIKRVRLqGMEKRYPH---ELSGGQQQRVAFARAIVTKPHFILFDEPLSALDA--------ILRE 174
Cdd:PLN03130 1341 daDLWESLErahlkDVIRRNSL-GLDAEVSEageNFSVGQRQLLSLARALLRRSKILVLDEATAAVDVrtdaliqkTIRE 1419

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446273968  175 EMRlelmdivhsiGLTALYVTHdQTEAMSMSDQIIVMKQGEVLQKGTPEDIYVKPSHEFvAKFV---GKAN 242
Cdd:PLN03130 1420 EFK----------SCTMLIIAH-RLNTIIDCDRILVLDAGRVVEFDTPENLLSNEGSAF-SKMVqstGAAN 1478

uvra

TIGR00630

excinuclease ABC, A subunit; This family is a member of the ABC transporter superfamily of ...

138-225

7.95e-04

Pssm-ID: 273184 [Multi-domain] Cd Length: 925 Bit Score: 41.15 E-value: 7.95e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  138 LSGGQQQRVAFARAI---VTKPHFILFDEPLSALDAilrEEMRlELMDIVHSI---GLTALYVTHDqTEAMSMSDQIIVM 211
Cdd:TIGR00630 830 LSGGEAQRIKLAKELskrSTGRTLYILDEPTTGLHF---DDIK-KLLEVLQRLvdkGNTVVVIEHN-LDVIKTADYIIDL 904

                          90       100
                  ....*....|....*....|
gi 446273968  212 ------KQGEVLQKGTPEDI 225
Cdd:TIGR00630 905 gpeggdGGGTVVASGTPEEV 924

PLN03073

ABC transporter F family; Provisional

130-169

9.70e-04

ABC transporter F family; Provisional

Pssm-ID: 215558 [Multi-domain] Cd Length: 718 Bit Score: 41.00 E-value: 9.70e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 446273968 130 MEKRYPHELSGGQQQRVAFARAIVTKPHFILFDEPLSALD 169
Cdd:PLN03073 337 MQVKATKTFSGGWRMRIALARALFIEPDLLLLDEPTNHLD 376

ABC_UvrA

cd03238

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...

3-214

1.44e-03

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.

Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 38.84 E-value: 1.44e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968   3 IKISGLEKNfgktqALKPLQIVMKQGEFTTLLGPSGCGKTTLLRmiagleepdkgeiyfgdTCMYSSAKK--IKTSPHER 80
Cdd:cd03238    1 LTVSGANVH-----NLQNLDVSIPLNVLVVVTGVSGSGKSTLVN-----------------EGLYASGKArlISFLPKFS 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  81 NIGMVFQDfalwphmnvfenvafglratkqtnQLREKVEDAIKRVRL-QGMEKrypheLSGGQQQRVAFARAIVTKPHFI 159
Cdd:cd03238   59 RNKLIFID------------------------QLQFLIDVGLGYLTLgQKLST-----LSGGELQRVKLASELFSEPPGT 109

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 160 LF--DEPLSALDailrEEMRLELMDIVHSI---GLTALYVTHDQTeAMSMSDQIIVMKQG 214
Cdd:cd03238  110 LFilDEPSTGLH----QQDINQLLEVIKGLidlGNTVILIEHNLD-VLSSADWIIDFGPG 164

sufC

PRK09580

cysteine desulfurase ATPase component; Reviewed

18-169

1.60e-03

cysteine desulfurase ATPase component; Reviewed

Pssm-ID: 181965 [Multi-domain] Cd Length: 248 Bit Score: 39.39 E-value: 1.60e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  18 LKPLQIVMKQGEFTTLLGPSGCGKTTLLRMIAGLE--EPDKGEIYFgdtcmySSAKKIKTSPHER---NIGMVFQDFALW 92
Cdd:PRK09580  17 LRGLNLEVRPGEVHAIMGPNGSGKSTLSATLAGREdyEVTGGTVEF------KGKDLLELSPEDRageGIFMAFQYPVEI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968  93 PHMN--VFENVAF-GLRATKQTNQL-REKVEDAIK-RVRLQGMekryPHEL---------SGGQQQRVAFARAIVTKPHF 158
Cdd:PRK09580  91 PGVSnqFFLQTALnAVRSYRGQEPLdRFDFQDLMEeKIALLKM----PEDLltrsvnvgfSGGEKKRNDILQMAVLEPEL 166

                        170
                 ....*....|.
gi 446273968 159 ILFDEPLSALD 169
Cdd:PRK09580 167 CILDESDSGLD 177

ABC_UvrA_I

cd03270

ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair ...

138-220

2.00e-03

ATP-binding cassette domain I of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.

Pssm-ID: 213237 [Multi-domain] Cd Length: 226 Bit Score: 39.16 E-value: 2.00e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 138 LSGGQQQRVAFARAIVTKPHFIL--FDEPLSALDAilREEMRL-ELMDIVHSIGLTALYVTHDQtEAMSMSDQIIVM--- 211
Cdd:cd03270  138 LSGGEAQRIRLATQIGSGLTGVLyvLDEPSIGLHP--RDNDRLiETLKRLRDLGNTVLVVEHDE-DTIRAADHVIDIgpg 214

                         90
                 ....*....|..
gi 446273968 212 ---KQGEVLQKG 220
Cdd:cd03270  215 agvHGGEIVAQG 226

SpoIIIAA

COG3854

Stage III sporulation protein SpoIIIAA [Cell cycle control, cell division, chromosome ...

31-49

2.73e-03

Stage III sporulation protein SpoIIIAA [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 443063 Cd Length: 309 Bit Score: 38.98 E-value: 2.73e-03

                         10
                 ....*....|....*....
gi 446273968  31 TTLLGPSGCGKTTLLRMIA 49
Cdd:COG3854  143 TLIISPPGCGKTTLLRDIA 161

ABC_Class2

cd03227

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ...

136-212

3.03e-03

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.

Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 37.72 E-value: 3.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 136 HELSGGQQQRVA----FARAIVTKPHFILFDEPLSALDaiLREEMRLELMDIVHSI-GLTALYVTHDQtEAMSMSDQIIV 210
Cdd:cd03227   76 LQLSGGEKELSAlaliLALASLKPRPLYILDEIDRGLD--PRDGQALAEAILEHLVkGAQVIVITHLP-ELAELADKLIH 152


                 ..
gi 446273968 211 MK 212
Cdd:cd03227  153 IK 154

PRK13342

recombination factor protein RarA; Reviewed

19-50

5.79e-03

recombination factor protein RarA; Reviewed

Pssm-ID: 237355 [Multi-domain] Cd Length: 413 Bit Score: 38.14 E-value: 5.79e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 446273968  19 KPLQIVMKQGEFTTLL--GPSGCGKTTLLRMIAG 50
Cdd:PRK13342  25 KPLRRMIEAGRLSSMIlwGPPGTGKTTLARIIAG 58

ABCC_SUR2

cd03288

ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The ...

120-233

6.33e-03

ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.

Pssm-ID: 213255 [Multi-domain] Cd Length: 257 Bit Score: 37.58 E-value: 6.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446273968 120 DAIKRVRLQGMEKRYPHEL-----------SGGQQQRVAFARAIVTKPHFILFDEPLSALDailreeMRLElmDIVHSIG 188
Cdd:cd03288  128 EALEIAQLKNMVKSLPGGLdavvteggenfSVGQRQLFCLARAFVRKSSILIMDEATASID------MATE--NILQKVV 199

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446273968 189 LTA------LYVTHDQTEAMSmSDQIIVMKQGEVLQKGTPEDIYVKPSHEF 233
Cdd:cd03288  200 MTAfadrtvVTIAHRVSTILD-ADLVLVLSRGILVECDTPENLLAQEDGVF 249

AAA

cd00009

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...

12-49

7.28e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.

Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 36.36 E-value: 7.28e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 446273968  12 FGKTQALKPLQIVMKQGEFTTLL--GPSGCGKTTLLRMIA 49
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLlyGPPGTGKTTLARAIA 40

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01