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Conserved domains on  [gi|446278777|ref|WP_000356632|]
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MULTISPECIES: PadR family transcriptional regulator [Bacillus]

Protein Classification

PadR family transcriptional regulator( domain architecture ID 11447737)

PadR family transcriptional regulator similar to the phenolic acid decarboxylation repressor, which is a transcription factor that represses genes associated with the phenolic acid stress response in gram-positive bacteria

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  10679470|10908318|10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
1-101 2.35e-35

DNA-binding transcriptional regulator, PadR family [Transcription];


:

Pssm-ID: 441301  Cd Length: 102  Bit Score: 116.57  E-value: 2.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446278777   1 MDKEILKGSIDILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITT 80
Cdd:COG1695    1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                         90       100
                 ....*....|....*....|.
gi 446278777  81 SGKKMLEEKLTAWDSVTALIK 101
Cdd:COG1695   81 AGREELAEWLEEWEKLAEALE 101
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
1-101 2.35e-35

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 116.57  E-value: 2.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446278777   1 MDKEILKGSIDILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITT 80
Cdd:COG1695    1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                         90       100
                 ....*....|....*....|.
gi 446278777  81 SGKKMLEEKLTAWDSVTALIK 101
Cdd:COG1695   81 AGREELAEWLEEWEKLAEALE 101
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 6-100 6.35e-28

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 97.63  E-value: 6.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446278777    6 LKGSIDILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITTSGKKM 85
Cdd:TIGR03433   1 LQGTLDLLILKTLSLGPLHGYGIAQRIQQISEDVLQVEEGSLYPALHRLERRGWIAAEWGESENNRRAKFYRLTAAGRKQ 80

                          90
                  ....*....|....*
gi 446278777   86 LEEKLTAWDSVTALI 100
Cdd:TIGR03433  81 LAAETESWARLSAAI 95
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 14-87 1.38e-25

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 90.77  E-value: 1.38e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446278777   14 LLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITTSGKKMLE 87
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
lstR PRK09416
PadR family transcriptional regulator;
11-86 1.76e-07

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 46.32  E-value: 1.76e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446278777  11 DILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESEtgmkRKFYRITTSGKKML 86
Cdd:PRK09416  44 ILLAILQLLMNEKTGYELLQLLRQRGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEG----AKYYQLTDKGNKML 115
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
13-88 4.75e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 33.72  E-value: 4.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446278777    13 LLLSIIKQHDTYG-YEIIQKLKensndlytMSQGTLYPALKRLEQKDLIHSYwgESETGMKRKFYRITTSGKKMLEE 88
Cdd:smart00347  14 LVLRILYEEGPLSvSELAKRLG--------VSPSTVTRVLDRLEKKGLVRRE--PSPEDRRSVLVSLTEEGRELIEQ 80
 
Name Accession Description Interval E-value
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
1-101 2.35e-35

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 116.57  E-value: 2.35e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446278777   1 MDKEILKGSIDILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITT 80
Cdd:COG1695    1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                         90       100
                 ....*....|....*....|.
gi 446278777  81 SGKKMLEEKLTAWDSVTALIK 101
Cdd:COG1695   81 AGREELAEWLEEWEKLAEALE 101
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 6-100 6.35e-28

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 97.63  E-value: 6.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446278777    6 LKGSIDILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITTSGKKM 85
Cdd:TIGR03433   1 LQGTLDLLILKTLSLGPLHGYGIAQRIQQISEDVLQVEEGSLYPALHRLERRGWIAAEWGESENNRRAKFYRLTAAGRKQ 80

                          90
                  ....*....|....*
gi 446278777   86 LEEKLTAWDSVTALI 100
Cdd:TIGR03433  81 LAAETESWARLSAAI 95
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 14-87 1.38e-25

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 90.77  E-value: 1.38e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446278777   14 LLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRITTSGKKMLE 87
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
lstR PRK09416
PadR family transcriptional regulator;
11-86 1.76e-07

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 46.32  E-value: 1.76e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446278777  11 DILLLSIIKQHDTYGYEIIQKLKENSNDLYTMSQGTLYPALKRLEQKDLIHSYWGESEtgmkRKFYRITTSGKKML 86
Cdd:PRK09416  44 ILLAILQLLMNEKTGYELLQLLRQRGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEG----AKYYQLTDKGNKML 115
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
14-79 9.91e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.78  E-value: 9.91e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446278777  14 LLSIIKQHDTYGYEIIQKLKensndlytMSQGTLYPALKRLEQKDLIHSYWGESETGMKRKFYRIT 79
Cdd:COG1777   22 ILALLSEEPAYVSELARELG--------VSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLS 79
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
13-88 4.75e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 33.72  E-value: 4.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446278777    13 LLLSIIKQHDTYG-YEIIQKLKensndlytMSQGTLYPALKRLEQKDLIHSYwgESETGMKRKFYRITTSGKKMLEE 88
Cdd:smart00347  14 LVLRILYEEGPLSvSELAKRLG--------VSPSTVTRVLDRLEKKGLVRRE--PSPEDRRSVLVSLTEEGRELIEQ 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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