|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
20-384 |
9.97e-100 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 301.05 E-value: 9.97e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLF 99
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 100 ASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCT 179
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 180 IVSLILTKLLQIKKSPQPPKQTSGT-FLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADISLFL-FNALAI 257
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTrAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFtVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 258 AVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATAT 337
Cdd:cd17489 241 LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446425409 338 FFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYITSV 384
Cdd:cd17489 321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-381 |
2.99e-53 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 181.24 E-value: 2.99e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLF 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 100 ASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCT 179
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 180 IVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLM------YGGIGSFITLFATEVGIADIS----L 249
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIfvlafaFGALEPFLPLYAAELGGLSPAqiglL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 250 FLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPH 329
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446425409 330 RRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYI 381
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-348 |
6.08e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 153.21 E-value: 6.08e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 177 SCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEV---GIADISLFLF- 252
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlglSASAAGLLLAl 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 253 NALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRG 332
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARG 331
|
330
....*....|....*.
gi 446425409 333 VATATFFSAFDLGIGA 348
Cdd:COG2814 332 RASGLYNSAFFLGGPL 347
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-381 |
6.80e-29 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 115.75 E-value: 6.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 177 SCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLM--YGGIGSFITLFATEVGIADIS----LF 250
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFflYFAFLTYLPFLLELLYGISPIiiglLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 251 LFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGI-ILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPH 329
Cdd:cd17474 241 AGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSlLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446425409 330 RRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYI 381
Cdd:cd17474 321 ERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-350 |
7.26e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.51 E-value: 7.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYV-KEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYL 98
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSC 178
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 179 TIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPS------LLILCITLMYGGIGSFITLFATEVGIADIS---L 249
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDpvlwllLALLLFGFAFFGLLTYLPLYQEVLGLSALLaglL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 250 FLFNALAIAVTRPFSGKLYDAKGHS---FVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRV 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 446425409 327 APHRRGVATATFFSAFDLGIGAGA 350
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
18-381 |
2.24e-24 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 103.01 E-value: 2.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 18 VALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSK-KIILMIGTAICLLAMGS 96
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSALAKPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQ--TYNFTILFLC 174
Cdd:cd17370 82 LALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYllGGNYRTIFLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 175 ALSCTIVSLILtkLLQIKKSPQPPKQTSGTflDGFIERKALLPSLLILCITLMYGGIG----SFITLFATEVGIADISLF 250
Cdd:cd17370 162 AAIPALLALLI--LLFVVKEYPRPPKLRKK--SKKTSLKKLPKAFWLYLLAVALFALGnfsfAFLILRAQELGLSAALIP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 251 LFNALA---IAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVA 327
Cdd:cd17370 238 LLYALFnlvYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446425409 328 PHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYI 381
Cdd:cd17370 318 AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-379 |
3.29e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 102.63 E-value: 3.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 19 ALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYL 98
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSC 178
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 179 TIVSLILTKLL--QIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEV----GIADISLFLF 252
Cdd:cd17324 163 ALLAALLLWRLlpSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpgfsSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 253 NALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWmIDRVAPHRRG 332
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARG 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446425409 333 VATATFFSAFDLGIGAGAIIFG-FIAHFTNYATVYRYSSLLLIAFLFI 379
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGlVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-388 |
9.73e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.10 E-value: 9.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 177 SCTIVSLILTkllqikkspqppkqtsgtfldgfierkALLPSLLILCITLMYGGIGSFITLFATEVGIADIS----LFLF 252
Cdd:COG2271 172 LPGLLLALLR---------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAqaglLLSL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 253 NALAIAVTRPFSGKLYD--AKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHR 330
Cdd:COG2271 225 PFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446425409 331 RGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYITSVKKQK 388
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-382 |
1.02e-21 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 95.37 E-value: 1.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYV-KEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYL 98
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQtYNFTILFLCALSC 178
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 179 ----TIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADIS----LF 250
Cdd:cd17329 163 fllaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESllglLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 251 LFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHR 330
Cdd:cd17329 243 ALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDK 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446425409 331 RGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYIT 382
Cdd:cd17329 323 RGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-186 |
1.04e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 95.34 E-value: 1.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKEIGG-TSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLA 93
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 94 MGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFL 173
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|...
gi 446425409 174 CALSCTIVSLILT 186
Cdd:cd17325 359 AAAALLLLAAVLF 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
22-382 |
1.45e-21 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 95.02 E-value: 1.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 22 LANLCMFLGFQMLIPTLPVYVKEIGGTSSNI-----GFVVGMFTVAALFVRPLTGNALQKFSKKIILM---IGTAICLLA 93
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLrasLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 94 MGsylFASTVFLLLAVRILHGAgFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFL 173
Cdd:cd17391 83 MA---FVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 174 CALSCTIVSLILTkLLQIKKSPQPP---KQTSGTFLDGFIERKALLPSLLI--LCITLMYGGIGSFITLF-----ATEVG 243
Cdd:cd17391 159 ITGGLLFLAFLLT-LFFVKEDFKPVekkKMVSTKEVWNSVPNPSLLISLFVttFIIQLANQSIEPILTLYirqlmGDASN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 244 IADISLFLFNALAIA--VTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAW 321
Cdd:cd17391 238 LAFISGLVFSATGVSslLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425409 322 MIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFI-AHFTNYATVYRYSSLLLIAFLFIYIT 382
Cdd:cd17391 318 LAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
20-366 |
4.14e-21 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 93.82 E-value: 4.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVR-PLTGNALQKFSKKIILMIGTAICLLAMGSYL 98
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRiPLGILSDRIGKRKLFIIIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 FASTVFLLLAVRILHGAGfGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSC 178
Cdd:cd17490 81 LFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 179 TIVSLILTKLLQIKKSPQPPKQTSG-TFLDGFIERKALLPSLLILCIT-LMYGGIGSFITLFATEVGIADISL----FLF 252
Cdd:cd17490 160 GVLGFILSLFIKEERREKKPVLTELkELLSVLKDKKLLFFSLLAILQQmITFSTTFGFTPLIAKQLGASSFQLgllsIIY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 253 NALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRG 332
Cdd:cd17490 240 LLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRS 319
|
330 340 350
....*....|....*....|....*....|....
gi 446425409 333 VATATFFSAFDLGIGAGAIIFGFIAHFTNYATVY 366
Cdd:cd17490 320 TAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGF 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-389 |
5.42e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.79 E-value: 5.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 177 SCTIVSLILTkLLQIKKSP----QPPKQTSGTFLDGFIERKALLPSLL-ILCITLMYGGIGSFITLFATEVGIADISLFL 251
Cdd:COG2223 167 ILLLVVAVLA-WLFLRDPPagaaAAAKASLRDQLEALRDPRFWLLSLLyFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 252 FNALAI---AVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTT-TIPSLIIAAACYGSGFGAIQPALQAWMIDRVA 327
Cdd:COG2223 246 LAALFAllgALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446425409 328 PHRRGVATATFFSAFDLGIGAGAIIFGFI-AHFTNYATVYRY-SSLLLIAFLFIYITSVKKQKH 389
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALlDATGSYTAAFLVfAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-383 |
1.20e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 92.68 E-value: 1.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMI-----GTAICL 91
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTIL 171
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 172 FLCALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDG------FIERKALLPSLLILCITLM-YGGIGSFITLFATEV-G 243
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLreglryLRRSPLLRLLLLALALFALlGGALTVLLPLLAKEVlG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 244 IADISLFLFNA---LAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQA 320
Cdd:cd06173 241 GGAAGYGLLLAafgVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446425409 321 WMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYITS 383
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-359 |
8.19e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 8.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVA-ALFVrPLTGNALQKFSKKIILMIGTAICLLAMGSYL 98
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAfAALL-LLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSC 178
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 179 TIVSLILTKLLqikkspqppkqtsgtfldgfierkaLLPSLLILCITLMYGGIGSFITLFATEVGIADIS----LFLFNA 254
Cdd:cd17321 160 GLVALLLARTF-------------------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLqaglALLPLA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 255 LAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYT---TTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRR 331
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA 294
|
330 340
....*....|....*....|....*...
gi 446425409 332 GVATATFFSAFDLGIGAGAIIFGFIAHF 359
Cdd:cd17321 295 GAASGILNTARQLGGALGVALLGALLTA 322
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-381 |
1.01e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 89.54 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 33 MLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRIL 112
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 113 HGAGFGITTTTYGTVVSDLIPqARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN---FTILFLCALSCTIVSLILTKLL 189
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGglgLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 190 QIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGI----ADISLFLFnALAIAVTRPFSG 265
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYslvfAGLLLSLF-LFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 266 KLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSlIIAAACYGSGFGAIQPALQAwMIDRVAPHRRGVATATFFS-AFDL 344
Cdd:cd17478 252 PLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWS-YILLVLAGFLLFASFPVTVV-LAQELLPGNVGLASGLMMGlSFGL 329
|
330 340 350
....*....|....*....|....*....|....*..
gi 446425409 345 GiGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYI 381
Cdd:cd17478 330 G-GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
28-387 |
3.36e-19 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 88.58 E-value: 3.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 28 FLGFQ---MLIPTLPVYV-KEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFAST- 102
Cdd:PRK12382 25 FLTYMtvgLPLPVIPLFVhHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLAYLLAAIl 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 103 -------VFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTilflcA 175
Cdd:PRK12382 105 pvsapfkFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGFA-----A 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 176 LSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADISLFLFN-A 254
Cdd:PRK12382 180 LALTTMVLPLLAWAFNGTVRKVPAHAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFTLTAfG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 255 LAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVA 334
Cdd:PRK12382 260 GAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTA 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446425409 335 TATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYITSVKKQ 387
Cdd:PRK12382 340 LGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFRRG 392
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-379 |
8.77e-19 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 86.86 E-value: 8.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEI---GGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAgFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 177 SCTIVSLILTKllqikkspqppkqtsgtfldgFIERKALLPSLLILCITLMYGGIGSFITLFA---TEVGIADISLFL-- 251
Cdd:cd17330 160 ALALLNLVLVL---------------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLkdrFGFSPSQIGLLLal 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 252 FNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRR 331
Cdd:cd17330 219 VGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQ 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446425409 332 GVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFI 379
Cdd:cd17330 299 GKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-382 |
1.47e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.47 E-value: 1.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 51 NIGFVVGM-FTVAALFV---RPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGT 126
Cdd:cd17473 32 NSELLVPLlLTLPALFIalfAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 127 VVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSPQPPKQTSGTFL 206
Cdd:cd17473 112 LIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 207 DGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIAD---ISLFL-FNALAIAVTRPFSGKLYDAKGHSFVIIPGVI 282
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSaalIGLALaIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 283 ITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAH-FTN 361
Cdd:cd17473 272 LMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNlTGG 351
|
330 340
....*....|....*....|.
gi 446425409 362 YATVYRYSSLLLIAFLFIYIT 382
Cdd:cd17473 352 LSGAFLILGVLALVLAIVLLL 372
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
14-378 |
2.50e-18 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 86.09 E-value: 2.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 14 TKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNI-GFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLL 92
Cdd:PRK05122 14 TLRIVSIVMFTFISYLTIGLPLAVLPGYVHDQLGFSAFLaGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 93 AMGSYLFAS--------TVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQ 164
Cdd:PRK05122 94 SGLLYLLAGllaawpvlSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 165 TYNFTILflcALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFieRKALLPSLLILCITLMYGGIGSFITLFATEVGI 244
Cdd:PRK05122 174 WGGLAGL---GLLIMLLALLGLLLARPRPAVPPVKGERLPFRRVL--GRVWPYGMGLALASIGFGTIATFITLYYAARGW 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 245 --ADISLFLFNALAIAvTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWM 322
Cdd:PRK05122 249 dgAALALTLFGVAFVG-ARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446425409 323 IDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLL-LIAFLF 378
Cdd:PRK05122 328 VKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAaLLGLAL 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
20-378 |
1.97e-17 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 82.99 E-value: 1.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLF 99
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 100 ASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIgLWLMQTYNFTILFLCALsCT 179
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAV-LL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 180 IVSLILTKLLQiKKSPQPPKQTSGTFLDGFieRKALLPSLLILCITLMYGGIGSFITLFATEVGI--ADISLFL-FNALA 256
Cdd:cd17477 159 LLALVPLLLTR-RAAPEIEEAESISLRRLL--RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLsvAQAALLLaAFVLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 257 IAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYT-TTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVAT 335
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAAN 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446425409 336 ATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLF 378
Cdd:cd17477 316 AALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-366 |
2.81e-17 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 82.62 E-value: 2.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 38 LPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGF 117
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 118 GITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIK--KSP 195
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLDLRlfKDR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 196 QPPKQTSGTFLDGFierkALLPSLLILciTLMYGGIgsfITLFATEVGIadisLFLFNALAIAVTRPFSGKLYDAKGHSF 275
Cdd:cd17503 179 NFTLGLLLSFLLGL----GLFGAMFLL--PLYLQNV---LGYSAFESGL----VLAPGGLASAILSPLVGRLLDKFGPRL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 276 VIIPGVIITFAGIILLSY---TTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAG-AI 351
Cdd:cd17503 246 LLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGtAL 325
|
330
....*....|....*
gi 446425409 352 IFGFIAHFTNYATVY 366
Cdd:cd17503 326 LATLLTNRTQFHHSR 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-381 |
2.89e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.47 E-value: 2.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 100 ASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN------FTILFL 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgwravFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 174 CALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADI------ 247
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGglsvav 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 248 --SLFLFNALAIAVTRPFSGKLYD-AKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMID 324
Cdd:cd06174 241 agLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446425409 325 RVAPHRRGVATATFFSAFDLGIGAGAIIFGFI-AHFTNYATVYRYSSLLLIAFLFIYI 381
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-388 |
3.08e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.59 E-value: 3.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:COG0738 10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGeGMGYFGLSGTIAMALGPLIGLWLM------QTYNFTI 170
Cdd:COG0738 90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLIllglslSWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 171 LFLCALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADIS-- 248
Cdd:COG0738 169 ILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAta 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 249 --LFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRV 326
Cdd:COG0738 249 alGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425409 327 aPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYrYSSLLLIAFLFIYITSVKKQK 388
Cdd:COG0738 329 -GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF-LVPLVCYLLILLLALALKRKR 388
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
28-379 |
7.04e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 72.25 E-value: 7.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 28 FLGFQMLIPTLPVYVKEI-GGTSSNIGFVVGMFTVA-ALFVRPLtGNALQKFSKKIILMIGTAIclLAMGSYL--FASTV 103
Cdd:cd17472 9 MLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILFGLLL--FIAGSLLaaYATSI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 104 FLLLAVRILHGAGfGITTTTYgTVVSDLIPQARRGEGMGY----FGLSGTIAMALGPLIGlwlmQTYNFTILFLCALSCT 179
Cdd:cd17472 86 YGLILGRALQGSG-AISSVVM-ALLADLTREENRTKAMALigasIGIAFAISMVLGPLLA----AHLGVSGLFLITAILS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 180 IVSLILTklLQIKKSPQPPKQTSGTFLDGFIE----RKALLPSLLILCITLMYGGIGSFITLFATEVGIADISLFLF--N 253
Cdd:cd17472 160 LVSLLIL--LFFVPDPPKIVQISEKEKKKLKKllknKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVylP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 254 ALAIAVTRPFSGKLYDAKGH--SFVIIPGVI-ITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHR 330
Cdd:cd17472 238 AILIGFILMVPFVIYAEKKGkmKQVFVSSILlIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEY 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446425409 331 RGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFI 379
Cdd:cd17472 318 RGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLV 366
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-291 |
1.27e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.00 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 177 SCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADISLFLFNALA 256
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|....*
gi 446425409 257 IAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILL 291
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-379 |
2.23e-13 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 70.65 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVY-VKEIGGTSSNIGFVVGMFTVAALFVRPLTGN-ALQKFSKKIILMIGTAICLLAMGSY 97
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFlTEELGASPLQIGIFMTLSALSGIVVSQWLGRlSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 98 LFASTVFLLLAVRILHGAGFGITTT---TYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLC 174
Cdd:cd17471 81 AFLRNYWVLLLVGVVLLSLGAAAFPqlfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 175 ALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLpsLLILCITLMYGGIGSFIT---LFATEVGIADISLF- 250
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLL--LLFAAFTLLFAANSMYIIampLYVTNELGGSESWVg 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 251 LFNALAIAVTRPF---SGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDrVA 327
Cdd:cd17471 239 LLFGLAAALEIPImllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQD-LM 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446425409 328 PHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLL-LIAFLFI 379
Cdd:cd17471 318 PGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLaLLALVLL 370
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
25-381 |
3.03e-13 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 70.31 E-value: 3.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 25 LCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSK-KIILMIGTAICLLAMGSYLFASTV 103
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKrKALLLLSLLAAVLFFLSLFFVAQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 104 FLLLA-VRILHGAGFGITTTTYGTVVSDLIpqarrGEGMGYFG---LSGTIAMALG-PLIGLWLMQTY---NFTILFLCA 175
Cdd:cd17335 87 FWLLLlLVILGAFFSAPVVPLVDSITLQYL-----GEERERYGkqrLWGSIGFGIAaLLVGILIDRSStykNYTIAFYVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 176 LSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALlpsLLILCITLMYGGIG---SFITLFATEVGIADI---SL 249
Cdd:cd17335 162 AVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVL---AFLLVAFLMGFGHGliySFLFWHLQDLGGSKTligLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 250 FLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWmIDRVAPH 329
Cdd:cd17335 239 WTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSY-ASAAAPP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446425409 330 RRGVATATFFSA--FDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYI 381
Cdd:cd17335 318 GLRATAQGLLQGlyFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
28-189 |
6.54e-13 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 69.18 E-value: 6.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 28 FLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLL 107
Cdd:cd17390 9 LFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 108 AVRILHGAgFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN-FTILFLCALSCTIVSLILT 186
Cdd:cd17390 89 LSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGgFYYVALLCSAIFILNAGLV 167
|
...
gi 446425409 187 KLL 189
Cdd:cd17390 168 WFL 170
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-379 |
2.26e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.98 E-value: 2.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:COG2807 20 LLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQaRRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLC-A 175
Cdd:COG2807 100 RSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVwA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 176 LSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGI----ADISLFL 251
Cdd:COG2807 179 LLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLsaatAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 252 FNALAIaVTRPFSGKLYD-AKGHSFVIIPGVIITFAGIILLSYTTTiPSLIIAAACYGSGFGAIQPALQAWMIDRVA-PH 329
Cdd:COG2807 259 FQLAGI-PGSLLVPLLADrLGDRRPLLLLLGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARtPA 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446425409 330 RRGVATATFFSAFDLGIGAGAIIFGFIAHFTNyatVYRYSSLLLIAFLFI 379
Cdd:COG2807 337 EAAALSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVL 383
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
17-302 |
2.32e-12 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 67.63 E-value: 2.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMF-LGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMG 95
Cdd:cd17331 1 VLLIVHLNIVLYaTCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 96 SYLFASTVFLLLAVRI-------LHGAGfgittttygTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNF 168
Cdd:cd17331 81 LLAFASSVPMLFLSRLpsvfmhaMQAAQ---------MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 169 TILFLCALSCTIVSLILTKLL-------QIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGG--IGSFITLF- 238
Cdd:cd17331 152 QAAALVAAVGSLLSIVLVILLipsntksKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGlpIGMFQSMFs 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446425409 239 ----------ATEVGIADISLFLFNALAIAVTRPFSGKLYdakGHSFVIIPGVIITFAGIILLSYTTTIPSLII 302
Cdd:cd17331 232 lvamdffgltPEENGYLMSYAGVLGMVVQGLLVGPLTKRF---GERSLLKLSVALLAIGYLLLAFVTTVWQLLV 302
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-169 |
5.58e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 5.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKE-IGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLA 93
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 94 MGSYLFA--STVFLLLAVRILHGAGFGITTTTYGTVVSDLIP-------QARRGEGMGYFGLSGTIAMALGPLIGLWLMQ 164
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
....*
gi 446425409 165 TYNFT 169
Cdd:COG2211 388 LFGYV 392
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
33-356 |
6.27e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.45 E-value: 6.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 33 MLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRIL 112
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 113 HGAGFGITTTTYGtVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIK 192
Cdd:cd17504 94 QGIGGAVFPLAFA-LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 193 --KSPQPPKQTSGTFLDGFIerkalLPSLLILCITLMYGGIGSFITLFATEVGIadisLFLFNALAIAVTRPFSGKLYDA 270
Cdd:cd17504 173 llRRRNVLLANITALLAGFG-----MFMVFQLLPQLLQLPTPTGFGLGITEAGL----LLLPGALVMLIAGPLAGRLIAR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 271 KGHSFVIIPGVIITFAGIILLSYT-TTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAG 349
Cdd:cd17504 244 VGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323
|
....*..
gi 446425409 350 AIIFGFI 356
Cdd:cd17504 324 PAIAGAI 330
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-154 |
8.63e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.77 E-value: 8.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 9 REPLWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGG-TSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGT 87
Cdd:COG2814 201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446425409 88 AICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMAL 154
Cdd:COG2814 281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-190 |
1.21e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 65.71 E-value: 1.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIgfVVGMFTVAALFV---RPLTGNALQKFSKKIILMIGTAICL 91
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL--LGLLLALNALLIvllQFPVARLVERFRLRKILMIGILLFA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTIL 171
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLP 357
|
170
....*....|....*....
gi 446425409 172 FLCALSCTIVSLILTKLLQ 190
Cdd:cd17329 358 WLILAALGLIAAALLLGLQ 376
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
20-338 |
3.00e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.12 E-value: 3.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQMLIPTLPVYVKEIGGTSsNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIgtAICLLAMGSYL- 98
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLI--AIVIFELGSLLc 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 -FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALS 177
Cdd:cd17502 78 gLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 178 CTIVSLiltkllqikkspqppkqtsgtfldgfierkALLPSLLILCITLMYGGIGSFITLF-------------ATEVGI 244
Cdd:cd17502 158 IGGLAL------------------------------ALLRTILLSSIFGFLFGGALFGLIYylplyfqlvlgdsATKSGV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 245 ADISLFLFNALAIAVTRPFSGKLYdakGHSFVIIPGVIITFAGIILLS---YTTTIPSLIIAAACYGSGFGAIQPALQAW 321
Cdd:cd17502 208 RLLPLIIGLVIGSIISGALISKTG---RYKPLIVIGTILMSVGAGLLTtltLDTSKWLLIGYLILLGLGLGIGFQQPLVA 284
|
330
....*....|....*..
gi 446425409 322 MIDRVAPHRRGVATATF 338
Cdd:cd17502 285 VQNAVPPADVGVATATN 301
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-382 |
3.28e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 64.13 E-value: 3.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 19 ALILANLCMF--LGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:cd17320 1 LLLLALLVALgpLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN-----FTIL 171
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGwraifVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 172 FLCALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALlpsLLILCITLMYGGIGSFITLfATEVGIADISL-- 249
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFL---GYALALGLSFAGLFAYLAA-APFIYIEQLGLsp 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 250 ------FLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTT-----TIPSLIIAAACYGSGFGAIQPAL 318
Cdd:cd17320 237 aqfgllFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446425409 319 QAWMIDRVaPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYIT 382
Cdd:cd17320 317 TSLALEPF-PHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
20-323 |
3.34e-11 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 64.56 E-value: 3.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFL---GFQMLIPTLPVYVKEIGGTS-SNIGFVVGM-FTVAALF---VRPLTGNALQKFSKKIILM---IGTA 88
Cdd:PRK09874 16 LTVAWLGCFLtgaAFSLVMPFLPLYVEQLGVTGhSALNMWSGLvFSITFLFsaiASPFWGGLADRKGRKIMLLrsaLGMG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 89 ICLLAMGsylFASTVFLLLAVRILHGAGFGITTTTyGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNF 168
Cdd:PRK09874 96 IVMVLMG---LAQNIWQFLILRALLGLLGGFVPNA-NALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 169 TILFLCALSCTIVSLILTkLLQIKKSPQPPKQTSGTFLDGFI---ERKALLPSLLI--LCITLMYGGIGSFITLFATEVG 243
Cdd:PRK09874 172 RPVFFITASVLFLCFLVT-LFCIRENFQPVSKKEMLHMREVVtslKNPKLVLSLFVttLIIQVATGSIAPILTLYVRELA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 244 -----IADISLFLFNALAIA--VTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQP 316
Cdd:PRK09874 251 gnvsnIAFISGMIASVPGVAalLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLP 330
|
....*..
gi 446425409 317 ALQAWMI 323
Cdd:PRK09874 331 AVQTLLV 337
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-398 |
1.11e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 8 KREPLWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSN-IGFVVGMFTVAALFVRPLTGNALQKFSKK------ 80
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAAlVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrp 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 81 --IILMIGTAICLLAMGSYLFASTVFLL---LAVRILHGAGFGITTTTYGTVVSDLIPQAR-RGEGMGYFGLSGTIAMAL 154
Cdd:COG2211 83 wiLIGAIPLALSFVLLFTAPDLSPTGKLiyaLVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 155 GPLIGLWLMQTY------NFTILFLCALSCTIVSLILTkLLQIKKSPQPPKQTSG---TFLDGFIERKALLPSLLILCIT 225
Cdd:COG2211 163 ASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLT-FFGTKERPVPEEEKVSlkeSLKALLKNRPFLLLLLAYLLFF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 226 LMYGGIGSFITLFATEV-----GIADISLFLFNALAIAVTrPFSGKLYDAKGHSFVIIPGVIITFAGIILLSY--TTTIP 298
Cdd:COG2211 242 LALALVAALLLYYFKYVlglsaALVGLLLALYFLAALLGA-PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 299 SLIIAAACYGSGFGAIQPALQAWMIDRVAPHRR---GVATATFFSAFD----LGIGAGAIIFGFIAHFTNYATVYRYSS- 370
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTfaikLGQALAGALAGLLLALFGYVAGAAQSPs 400
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 446425409 371 ---------------LLLIAFLFIYITSVKKQKHGDKNTEKAA 398
Cdd:COG2211 401 altgirllffllpavLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
29-360 |
1.31e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 62.27 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 29 LGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVR----PLTGNALQKFSKKIIL---MIGTAICLLAMGsylFAS 101
Cdd:cd17388 13 MGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQfifaPILGALSDRFGRRPVLllsLAGAALDYLLMA---FAP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 102 TVFLLLAVRILhgAGF-GITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTI 180
Cdd:cd17388 90 TLWWLYLGRII--AGItGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 181 VSL----ILTKLLQIKKSPQPPKQTSGTF--LDGFIERKALLPSLLILCITLMYGGIGSFITLFATE---------VGIA 245
Cdd:cd17388 168 NFLlglfVLPESLPPERRRAFRWRRANPFgsLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEdrfdwsptmVGLS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 246 DISLFLFNALAIA-VTRPFSGKLYDAKghsfVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGfGAIQPALQAWMID 324
Cdd:cd17388 248 LAVFGLLHALFQAfVTGPIAKRLGEKR----AILLGLAADALGFLLLAFATQGWMVFPILILLALG-GIAGPALQGLLSR 322
|
330 340 350
....*....|....*....|....*....|....*.
gi 446425409 325 RVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFT 360
Cdd:cd17388 323 QVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-189 |
1.62e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 1.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 14 TKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSS-NIGFVVGMFTVAALFVRPLTGNALQK-FSKKIILMIGTAICL 91
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPiIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTIL 171
Cdd:cd17474 277 LSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356
|
170
....*....|....*...
gi 446425409 172 FLCALSCTIVSLILTKLL 189
Cdd:cd17474 357 FLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
218-399 |
2.12e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 218 SLLILCITLMYGGIGSFITLFATEVGIADISL-FLFNALAIA--VTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYT 294
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIgLIVAAYALAqlLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 295 TTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLI 374
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180
....*....|....*....|....*
gi 446425409 375 AFLFIYITSVKKQKHGDKNTEKAAG 399
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAA 186
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-398 |
5.02e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.37 E-value: 5.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 218 SLLILCITLMYGGIGSFITLFATEVGIADIS---LFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYT 294
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQaglVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 295 TTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLI 374
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLAL 175
|
170 180
....*....|....*....|....
gi 446425409 375 AFLFIYITSVKKQKHGDKNTEKAA 398
Cdd:COG2814 176 LALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
8-185 |
8.93e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.89 E-value: 8.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 8 KREPLWTKEFVALILANLCMFLGFQMLIpTLPVYVKEIGGTSS-NIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIG 86
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPI-QLPFLLQERGGGSAaLIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 87 TAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTY 166
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
170 180
....*....|....*....|....
gi 446425409 167 N-----FTILFLCALSCTIVSLIL 185
Cdd:cd17473 350 GglsgaFLILGVLALVLAIVLLLL 373
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
17-186 |
4.71e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 57.77 E-value: 4.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAicLLAMGS 96
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTF--AFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YL--FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLC 174
Cdd:TIGR00711 82 LLcgVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
170
....*....|..
gi 446425409 175 ALSCTIVSLILT 186
Cdd:TIGR00711 162 NVPIGIIVVVVA 173
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
43-382 |
6.95e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.81 E-value: 6.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 43 KEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTT 122
Cdd:cd17319 31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 123 TYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCalsCTIVSLILtkllqikkspqppkqts 202
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII---EGLLGLLL----------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 203 gTFLDGFIERKALLPSLLILCITLMYGGIGSFITLF--------ATEVGIADISLFLFNALAIAVTRPFSGKLYdAKGHS 274
Cdd:cd17319 171 -AVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYlkqargfsLKQVGLLAAIPFLAGAIGMILGGRLSDRLL-RGARR 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 275 FVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFG 354
Cdd:cd17319 249 LVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIG 328
|
330 340
....*....|....*....|....*....
gi 446425409 355 FIAHFT-NYATVYRYSSLLLIAFLFIYIT 382
Cdd:cd17319 329 YLVDATgSYTAAFLFLAAVALLAALLVLL 357
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
131-386 |
1.21e-08 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 56.44 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 131 LIPQARRGEGMGYFGLSGTIAMALG-PL---IGLWLMQTYNFTILFLCALsctIVSLILTKLLqikksPQPPKQTSGTF- 205
Cdd:PRK03545 125 VAPAGKKAQALSLLATGTALAMVLGlPLgrvIGQYLGWRTTFLAIGGGAL---ITLLLLIKLL-----PLLPSEHSGSLk 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 206 -LDGFIERKAL--LPSLLILCITLMYGGIgSFITLFATEVG-----IADISLFLFNALAIAVTRPFSgKLYDAKGHSFVI 277
Cdd:PRK03545 197 sLPLLFRRPALvsLYLLTVVVVTAHFTAY-SYIEPFVQQVAglsenFATLLLLLFGGAGIIGSVLFS-RLGNRHPSGFLL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 278 IPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIdRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIA 357
Cdd:PRK03545 275 IAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVL-KLAPDATDVAMALFSGIFNIGIGAGALLGNQVS 353
|
250 260
....*....|....*....|....*....
gi 446425409 358 HFTNYATVYRYSSLLLIAFLFIYITSVKK 386
Cdd:PRK03545 354 LHLGLSSIGYVGAALALAALVWSILIFRR 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-198 |
1.50e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.04 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 9 REPLWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTS-SNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGT 87
Cdd:COG2223 199 LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSaATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 88 AICLLAMGSYLFAS-TVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTY 166
Cdd:COG2223 279 ALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
|
170 180 190
....*....|....*....|....*....|...
gi 446425409 167 -NFTILFLCALSCTIVSLILTKLLQIKKSPQPP 198
Cdd:COG2223 359 gSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-155 |
1.67e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.03 E-value: 1.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 12 LWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGG-TSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAIC 90
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGySPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446425409 91 LLAMGSYLF---ASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALG 155
Cdd:cd17321 245 AVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
15-169 |
4.06e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 54.92 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAM 94
Cdd:cd17332 221 RPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 95 GSYLFAS--TVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQA-----RRGEGMGY--FGLSGTIAMALGPLIGLWLMQT 165
Cdd:cd17332 301 LLLFFLPpgNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGelktgKRREGIFYsvMTFFRKLGLALAGALVGLILSL 380
|
....
gi 446425409 166 YNFT 169
Cdd:cd17332 381 AGYV 384
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
22-379 |
4.60e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.55 E-value: 4.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 22 LANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFAS 101
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 102 TVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIV 181
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 182 SLILTKLLQikKSPQPPKQTSGTFLDGFIERKALL---PSLLILCITLMYGG----IGSFITLFATE---VGIADISLFL 251
Cdd:cd17475 163 AAVLFWLFY--REPPAASAATESASTLLRSLKEVLrnrDVWLIAIAGALLVApqfaLLTFLLLFLHDhlgLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 252 FNA-LAIAVTRPFSGKLYDakgHSF------VIIPGVIITFAGIILLSY-TTTIPSLIIAAACYGSGFGAI--QPALQAW 321
Cdd:cd17475 241 AVAqLGGALGRIGLGRVSD---RVFggrrrpVLVITAAIAAAALLVLSLlSPGTPLWLLVLLLILLGLFAIgwNGLYLTL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446425409 322 MIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFT-NYATVYRYSSLLLIAFLFI 379
Cdd:cd17475 318 VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAALL 376
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
49-379 |
4.61e-08 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 54.77 E-value: 4.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 49 SSNIGFVVGMFTVAALFVRPLTGN-ALQKFSKKIILMIGTAICLLAMGSYLFAS--TVFLLLAVRILHGAGFGITTTTYG 125
Cdd:COG2270 51 TALWGYALAIAGLLVALLAPVLGAiADRSGRKKPFLAFFTLLGVLATAALFFVApgGLWLGLLLFVLANIGFEGSLVFYN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 126 TVVSDLIPQARRGE------GMGYFG-----LSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQiKKS 194
Cdd:COG2270 131 AFLPDIATPEEIGRvsglgwALGYLGgvlllLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLP-ERP 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 195 PQPPKQTSGTFLDGFIERKALL------PSLLILCITLM-----YGGIGSFITLFATEV-GIADISLFLFNALAIAVTRP 262
Cdd:COG2270 210 RPGPAPPRGAVRAGFRELRRTLrelrryRDLLRFLLAYFfyrdgVQTVIAFAGIYAAGVlGFSTTELIVFGLLVQIVAAL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 263 FS---GKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIdRVAPHRRgvaTATFF 339
Cdd:COG2270 290 GAllfGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLA-RLIPPGR---EAEFF 365
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 446425409 340 SAFDLGIGAGAII----FGFIAHFTNYatvYRYSSLLLIAFLFI 379
Cdd:COG2270 366 GLYALSGKAASFLgpllFGLVTQLTGS---QRLGILSLIVFFVI 406
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-189 |
6.12e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.15 E-value: 6.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 21 ILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNalqKFSKKIILMIGTAICLLAMGSYL-- 98
Cdd:cd17490 201 LLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGT---LFYKKLGERNTIIIGFLLLGAYCfl 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 99 --FASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCAL 176
Cdd:cd17490 278 ipFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIG 357
|
170
....*....|...
gi 446425409 177 SCTIVSLILTKLL 189
Cdd:cd17490 358 VIALLAAILSLAY 370
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
17-291 |
7.59e-08 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 53.76 E-value: 7.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKI-----ILMIGTAICL 91
Cdd:cd17385 1 LISLALANFSSMICYSILAPFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFmfvagMFVSGGCTIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMGSYLFASTVFLLL--AVRILHGAGFGITTTTYGTVVSDLIPQaRRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFT 169
Cdd:cd17385 81 FGFLDRVPDGTVFIALcfLVRIVEAVGFAAFITASFAIIAKEFPN-NIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 170 ILFLcALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLIL----CITLMYGGIGSFITLF---ATEV 242
Cdd:cd17385 160 LPFL-VLGCLLLLTVPLNMFILPRYDDDPSPKSGSMLKLLKIPSVLLLCLSIVsgsvSLGFLDPTLSPHLRQFklsPGQV 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446425409 243 GIadisLFLFNALAIAVTRPFSGKLYDAKGH-SFVIIPGVIITFAGIILL 291
Cdd:cd17385 239 GL----MFLILAGSYAISAPLWGWLSDKKKIpKWLMVIGSIITGVGFLLL 284
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
38-364 |
1.16e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.15 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 38 LPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGF 117
Cdd:TIGR00881 18 MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 118 GITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTY--NFTILFLCALSCTIVSLILTKLLQikKSP 195
Cdd:TIGR00881 98 GMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELysWHWVFIVPGIIAIIVSLICFLLLR--DSP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 196 QPPKQTS-----GTFLDGFIERKA------------LLPSLLILCITLMY-------GGIGSFITLFATEVG-----IAD 246
Cdd:TIGR00881 176 QSCGLPPaeempNEEPDGDAEKKEeeltkkqiflqyVLLNKVLWYISLGYvfvyvvrTGILDWSPLYLTQEKgfskeKAS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 247 ISLFLFNALAIAVTRP---FSGKLYDAKGHSFVIIPGVIITFA-GIILLSYTTTIPSLIIAAACYG-SGFGaiqPALQAW 321
Cdd:TIGR00881 256 WAFTLYELGGLVGTLLagwLSDKLFNGRRGPLAVFFMALIIVSlLVYWLNPAANPLMDLICLFALGfLVYG---PQMLIG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446425409 322 MIDRVAPHRRGVATATFFSAFDLGIGAGA--IIFGFIAHFTNYAT 364
Cdd:TIGR00881 333 VIASELAPKKAAGTAAGFVGFFAYLGGILagLPLGYLADGFGWAG 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
249-399 |
1.62e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.81 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 249 LFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAP 328
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446425409 329 HRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLFIYITSVKKQKHGDKNTEKAAG 399
Cdd:pfam07690 117 EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-185 |
1.75e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 1.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYV-KEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLA 93
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSMYIIAMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 94 MGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQaRRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFL 173
Cdd:cd17471 279 YLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPG-QPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFL 357
|
170
....*....|..
gi 446425409 174 CALSCTIVSLIL 185
Cdd:cd17471 358 VCAVLALLALVL 369
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
219-398 |
5.85e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.03 E-value: 5.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 219 LLILCITLMYG---GIGSFITLFATEVGIADISLFLFNALAI---AVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLS 292
Cdd:COG2223 9 LATLAFFLAFGvwyLWSVLAPPLAEEFGLSAAQLGLLFAIPVlvgALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 293 YTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLL 372
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGIL 168
|
170 180
....*....|....*....|....*.
gi 446425409 373 LIAFLFIYITSVKKQKHGDKNTEKAA 398
Cdd:COG2223 169 LLVVAVLAWLFLRDPPAGAAAAAKAS 194
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
17-185 |
9.27e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 50.24 E-value: 9.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTG-----NALQKFSKKIILMIGTAICL 91
Cdd:cd17352 185 FVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGlladkPRIGRLYLYIFTLLILGLSL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMgsyLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALG-PLIGLWLMQTYNFTI 170
Cdd:cd17352 265 LAF---PLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDYDA 341
|
170
....*....|....*
gi 446425409 171 LFLCALSCTIVSLIL 185
Cdd:cd17352 342 AFYFCGACLLLSGVL 356
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-189 |
9.73e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 9.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 12 LWTKEFVALILANLCMFLGFQMLIPTLPVYVKEI-GGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAIC 90
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 91 LLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTI 170
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 446425409 171 LFLCALSCTIVSLILTKLL 189
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-189 |
1.11e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 50.27 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 19 ALILANLCMFL---GFQMLIPTLPVYVKE-----IGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAIC 90
Cdd:cd17504 178 NVLLANITALLagfGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 91 LLA-MGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN-- 167
Cdd:cd17504 258 AVGlLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvs 337
|
170 180 190
....*....|....*....|....*....|...
gi 446425409 168 -----------FTILFLCALSCTIVSLILTKLL 189
Cdd:cd17504 338 itsggvptegaYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
15-189 |
1.18e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.88 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTS-SNIGFVVGMFTVAALFVRPLTG---NALQKFSKKIILMIGTAIC 90
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSlKQVGLLAAIPFLAGAIGMILGGrlsDRLLRGARRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 91 LLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQ-TYNFT 169
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYT 338
|
170 180
....*....|....*....|
gi 446425409 170 ILFLCALSCTIVSLILTKLL 189
Cdd:cd17319 339 AAFLFLAAVALLAALLVLLL 358
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
17-375 |
4.82e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.42 E-value: 4.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPtlpvYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:cd17355 9 FLILILSWGIRYYFGVFIIP----IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVF-LLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNF--TILFL 173
Cdd:cd17355 85 LALATSLWqLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrtALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 174 CALSCTIVSLILTKLLQIKKSPQPPKQTSGTFLDGFIERKALL--PSLLILCITLMyggIGSFITLFATEVGIADISLFL 251
Cdd:cd17355 165 ALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALrsASFWLLALAFF---LCGFAVVGLIVHLVPYLADRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 252 FNALAIAVT-----------RPFSGKLYDAKGHSFVIIPGVIITFAGIILLSY-TTTIPSLIIAAACYGSGFGAIQPALQ 319
Cdd:cd17355 242 ISPAAAAVAlaliglfnivgRLLSGWLGDRYSPRRLLAASYALRALGLALLLLlPFPPLALLLFAALFGLGWGATVPLTA 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446425409 320 AWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFT-NYATVYRYSSLLLIA 375
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLI 378
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
17-376 |
8.68e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 47.57 E-value: 8.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANlcMFLgfQMLIPTLPVYVKEiggtSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:cd17384 6 YVALLLDN--MLL--TVVVPIIPDYLNE----NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIP-QARRGEGMGyFGLSGtiaMALGPLIGL--------WLMQTYN 167
Cdd:cd17384 78 FAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPdDKERGKAMG-IALGG---LALGVLVGPpfggvmyeFVGKSAP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 168 FtiLFLCALSCTIVSLiltKLLQIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMygGIGSF-----ITLFAT-- 240
Cdd:cd17384 154 F--LILAFLALLDGAL---QLFILQPSVKSEESEEGTPWKTLLKDPYILIAAGAICFSNS--GIAILepclpIWMMETmc 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 241 ----EVGIAdislFLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQP 316
Cdd:cd17384 227 ppkwQLGTA----FLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDS 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446425409 317 AL---QAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAF 376
Cdd:cd17384 303 SMmplLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILY 365
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
15-159 |
1.21e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKI----ILMIGTAIC 90
Cdd:cd17391 201 SLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIghhrILLGALLAS 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446425409 91 LLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIG 159
Cdd:cd17391 281 ALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
41-381 |
1.72e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.39 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 41 YVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTV-FLLLAVRILHGAGFGI 119
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLwQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 120 TTTTYGTVVSDLIpQARRGEGMGyFGLSGT-IAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSPqpp 198
Cdd:cd17352 109 IYSPAIVIVGQYF-EKKRGLATG-IAVAGSgVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLRLLKDP--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 199 kqtsgTFLdgfierkallpsLLILCITLMYGGIGSFITL---FATEVGIADISL-FLFNALAIA--VTRPFSGKLYDAKG 272
Cdd:cd17352 184 -----TFV------------LLALGVSFAMLGFFVPFVYlpsYAKSLGIDESDAaFLLSIIGISdiVGRILLGLLADKPR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 273 HSFVIIPGVIITFAGIILLSYT--TTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGA 350
Cdd:cd17352 247 IGRLYLYIFTLLILGLSLLAFPlaTTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGP 326
|
330 340 350
....*....|....*....|....*....|..
gi 446425409 351 IIFGFIAHFT-NYATVYRYSSLLLIAFLFIYI 381
Cdd:cd17352 327 PIAGLLRDYTgDYDAAFYFCGACLLLSGVLLF 358
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
38-378 |
2.68e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 46.08 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 38 LPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKI-----ILMIGTAICLLAMGSYLFASTVFLLLAVRIL 112
Cdd:cd17313 22 VPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIgrrrpFILVGAPLAALGLILIPNAADIGLALGDGPR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 113 HgagFGITTTTYGTVV----------------SDLIPQARRGEGMGYFGLSGTIAMALGPLIG--LWLMQTYNFTILFLC 174
Cdd:cd17313 102 T---WALVLFVLGIVLldfamnvcqgpvrallPDLVPPEQRSKANGIINFMGGLGGVLGYLLGaiLWDHNWFGFALGGNL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 175 ALSCTIVSLILT---------------KLLQIKKSPQPPKQTSGTFLDGFIerKALLPSLLILCITLMYGGIG-----SF 234
Cdd:cd17313 179 KVPFYIGAIILLvcvlvtlffvkepplSPEAGEHSENPSLGEVLKSLLKLL--KIMPRSLLRLLLVIFFWWIAffpfeLF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 235 ITLFATE----------------VGIADISLFlFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIP 298
Cdd:cd17313 257 FTDYMGEevyhgtsaasshygagVRMGAWGLL-IFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVT 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 299 SLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATAT-------FFSAFDLGIGAGAIIFGFIAHfTNYATVYRYSSL 371
Cdd:cd17313 336 VALVLFALGGIGWATININPYPLVSDYHSESGRGQGTDTgllnlaiSLAQILVSLLAGPIIDVKGYG-TVFPVAAVASFL 414
|
....*..
gi 446425409 372 LLIAFLF 378
Cdd:cd17313 415 SLVGALF 421
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
12-190 |
4.81e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 12 LWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICL 91
Cdd:cd17335 195 LRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYV 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMG-YFGLSGTIAMALGPLIGLWLMQTYNFTI 170
Cdd:cd17335 275 VRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGlLQGLYFGLGGGLGSLIGGYLYEAFGART 354
|
170 180
....*....|....*....|
gi 446425409 171 LFLCALSCTIVSLILTKLLQ 190
Cdd:cd17335 355 TFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
18-366 |
6.67e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 44.56 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 18 VALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSY 97
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 98 LFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLipQARRGEGM-----GYFGLsGTIAMALGPLIGLWLmQTYNFTILF 172
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALDVAMNAQGVAV--ERAYGRPImsslhAMWSL-GGLAGALLGAAAIGA-GVSPGVHLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 173 LCALSCTIVSLILTKLLQIKKSPQ--PPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIADISL- 249
Cdd:cd17393 158 AAAVLLLLAALVAIRALLPGTGEAaeDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALa 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 250 ---FLFNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDR- 325
Cdd:cd17393 238 algYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALp 317
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446425409 326 VAPHRRGVATATFFSAfdLGIGAGAIIFGFIAHFTNYATVY 366
Cdd:cd17393 318 GLAAGIAVARVATLGY--LGFLVGPPLIGFLADATGLRTAF 356
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
14-135 |
7.08e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 14 TKEFVALILANLCMFLGFQMLIPTLPVYVKEIGGTSS-NIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLL 92
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAfESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 446425409 93 AMGSYLFA---STVFLLLAVRILHGAGFG-----ITTTTYGTVVSDLIPQA 135
Cdd:cd17503 257 GTLLLAFLtpdTSLWLIILPLFIRGLGMGlvfmpLNTLALNSLPPEQIGDA 307
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-162 |
7.11e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.53 E-value: 7.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 59 FTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRG 138
Cdd:cd17328 43 FIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100
....*....|....*....|....
gi 446425409 139 EGMGYFGLSGTIAMALGPLIGLWL 162
Cdd:cd17328 123 RALGVFYFAIPLGSGLGYVVGGLV 146
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
48-359 |
7.34e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.62 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 48 TSSNIGFVVGMFTVAALfvrpltgnaLQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTV 127
Cdd:cd17333 38 SSQNAGYLIGSLLAGFL---------MKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 128 VSDLIPQaRRGEGMGYF-GLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSPQ--PPKQTSGT 204
Cdd:cd17333 109 VGALFEE-SSATRLNVLhGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSarNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 205 FLDGFIE----RKALLPSLLILCITLMYGGIGSFITLFATE-----VGIADISLFLFnALAIAVTRPFSGKLYDAKGHSF 275
Cdd:cd17333 188 FSASASRllrnPSIILGALALFLYVGAETAFSSWVPSYLVEkkhvsDGLAGYLLSGF-WVGITIGRLLGGPISRRIKPHT 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 276 VIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVaPHRRGVATATFFSAFDLGIGAGAIIFGF 355
Cdd:cd17333 267 LLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGF 345
|
....
gi 446425409 356 IAHF 359
Cdd:cd17333 346 IAEA 349
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-186 |
8.97e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 8.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 12 LWTKEFVALILANLCMFLGFQMLIPTLPVYVKEIGG-TSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAIC 90
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 91 LLAMG--SYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGY-FGLSGTIAMALGPLIGLWLMQTYN 167
Cdd:cd17316 254 GILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGG 333
|
170
....*....|....*....
gi 446425409 168 FTILFLCALSCTIVSLILT 186
Cdd:cd17316 334 TGVPALILALLAIVALIVA 352
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
19-189 |
1.48e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.50 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 19 ALILANLCMFL-GFQMLIP--TLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMG 95
Cdd:TIGR00895 18 AIILSFLIMLMdGYDLAAMgfAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 96 SYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCA 175
Cdd:TIGR00895 98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVG 177
|
170
....*....|....
gi 446425409 176 lscTIVSLILTKLL 189
Cdd:TIGR00895 178 ---GIAPLLLLLLL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
56-379 |
1.62e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 56 VGMFTVAALFVRP----LTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDL 131
Cdd:cd17316 38 TGLLFAAGFLGRPigalLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 132 IPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFT----ILFLCALSCTIVSLILTKLLqikkspqppkqtsgtfld 207
Cdd:cd17316 118 APSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRT------------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 208 gfierkaLLPSLLILCITLMYGGIGSFITLFATEVGIADISLFLFNALAIAVT----RPFSGKLYDAKGHSFVIIPGVII 283
Cdd:cd17316 180 -------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGalvgALIAGLLSDRIGRKKTLVIGLIL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 284 TFAGIILLSY--TTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTN 361
Cdd:cd17316 253 SGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
330
....*....|....*...
gi 446425409 362 YATVYRYSSLLLIAFLFI 379
Cdd:cd17316 333 GTGVPALILALLAIVALI 350
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
20-160 |
1.88e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 43.35 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFL---GFQMLIPTLPVYVKEI--GGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSK-KIILMIGTAICLLA 93
Cdd:cd17326 1 IYVMYLTMFLsslQFSIVLTSIWPYLQKIdpTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSvKEPLIVSILIAIVG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446425409 94 MGSYLFASTV-----FLLLAVRILHGAGFGITTT--TYGTVVSDLIPQARrgeGMGYFGLSGTIAMALGPLIGL 160
Cdd:cd17326 81 NILYALAEYFpsnrkYVMLVARFLIGVGAGNVAVlrAYVAAASTLKDRTR---AMAVISAAQALGFIVGPALQA 151
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
36-173 |
1.94e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.37 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 36 PTLPVYVKEIGGTSSNIGFVVGMFT----VAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRI 111
Cdd:PRK09874 240 PILTLYVRELAGNVSNIAFISGMIAsvpgVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRF 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425409 112 LHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFL 173
Cdd:PRK09874 320 LLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFL 381
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
254-359 |
2.71e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.49 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 254 ALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGV 333
Cdd:COG0477 59 LLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGR 138
|
90 100
....*....|....*....|....*.
gi 446425409 334 ATATFFSAFDLGIGAGAIIFGFIAHF 359
Cdd:COG0477 139 ALGLWGAAIGLGLALGPLLGGLLVAA 164
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
53-162 |
4.08e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 42.26 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 53 GFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYgTVVSDLI 132
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVT 145
|
90 100 110
....*....|....*....|....*....|
gi 446425409 133 PQARRGEGMGYFGLSGTIAMALGPLIGLWL 162
Cdd:cd17389 146 SPKKRSKGMALIGVAFSLGFIIGPMIGAYF 175
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
15-185 |
8.86e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.07 E-value: 8.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 15 KEFVALILANLCMFLGFQMLIPTLPVYVKEI--GGTSSNI----------GFVVGMFTVAALFVRPLTGNALQKFSKKII 82
Cdd:cd17313 234 RSLLRLLLVIFFWWIAFFPFELFFTDYMGEEvyHGTSAASshygagvrmgAWGLLIFSLAFLIFSLPIGKLGKKIGRKKV 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 83 LMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGM--GYFGLSGTIAMALGPLIGL 160
Cdd:cd17313 314 YLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTdtGLLNLAISLAQILVSLLAG 393
|
170 180
....*....|....*....|....*
gi 446425409 161 WLMQTYNFTILFLCALSCTIVSLIL 185
Cdd:cd17313 394 PIIDVKGYGTVFPVAAVASFLSLVG 418
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
55-185 |
9.92e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.03 E-value: 9.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 55 VVGMfTVAALFVRPLTgnalQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQ 134
Cdd:cd17365 44 LFGM-AIGALLAGPLA----DRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPA 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 446425409 135 ARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLIL 185
Cdd:cd17365 119 RRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-167 |
1.22e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.07 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 18 VALILANLCMFLGFQMLIPTLPVYVKEIGGtSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSY 97
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGP-SSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 98 LFASTVFLLLAVRILHGAGFGiTTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN 167
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANA 148
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
255-357 |
1.41e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.24 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 255 LAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVA 334
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120
|
90 100
....*....|....*....|...
gi 446425409 335 TATFFSAFDLGIGAGAIIFGFIA 357
Cdd:cd17502 121 QGYIGAVFGIASVAGPLIGGAFT 143
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
222-398 |
2.20e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.91 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 222 LCITLMYGGIGSFITLFATEVGI--ADISLFL-FNALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIP 298
Cdd:cd17475 6 AAASLVAQGIPALAPFLQEDLHLslAQVGLLLsALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 299 SLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTNYATVYRYSSLLLIAFLF 378
Cdd:cd17475 86 VLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAV 165
|
170 180
....*....|....*....|
gi 446425409 379 IYITSVKKQKHGDKNTEKAA 398
Cdd:cd17475 166 LFWLFYREPPAASAATESAS 185
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-185 |
2.67e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 28 FLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIG---TAICLLAMGsyLFASTVF 104
Cdd:cd17365 184 LLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFfalGAVSLALLG--VSPASLV 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 105 LLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQ-----TYNFTILFLCALSCT 179
Cdd:cd17365 262 LLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAaglgpESVFLALAIPAALGA 341
|
....*.
gi 446425409 180 IVSLIL 185
Cdd:cd17365 342 LAVLLL 347
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
44-195 |
2.89e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.55 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 44 EIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLA---MGSYLFASTVFLLLAVRILHGAGFGIT 120
Cdd:cd17357 43 SDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSsllMFLSKSAKSPELLIFGRFLVGIACGLS 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446425409 121 TTTYGTVVSDLIPQARRGeGMGYF-GLSGTIAMALGPLIGLWLMQTYNFTILFLCALSCTIVSLILTKLLQIKKSP 195
Cdd:cd17357 123 TGFVPMYLQEISPSELRG-ALGSLtQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESP 197
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
36-160 |
4.39e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 38.71 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 36 PTLPVYVKEIGGTSSNI--GFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSYLFASTVFLLLAVRILH 113
Cdd:cd17315 18 GALLYIAKDLGFGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446425409 114 GAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGL 160
Cdd:cd17315 98 GLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGL 144
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
280-356 |
4.50e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 39.02 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 280 GVIITFAGIILLSYTTTIPSLIIAA---ACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFI 356
Cdd:cd06176 83 GLALAPFAALLLAGAAFWLGLALAVlafLLYGIGVGAAGTAFLALLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGRL 162
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
218-357 |
6.98e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.38 E-value: 6.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 218 SLLILCITLMYGGIGSFITLFATEVGIADISLFLFNA--LAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTT 295
Cdd:cd06179 4 CLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAwsLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAK 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425409 296 TIPSLIIAAACYGSGFGaIQPALQAWMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIA 357
Cdd:cd06179 84 SVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
20-382 |
8.07e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.00 E-value: 8.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 20 LILANLCMFLGFQ--MLIPTLPVYVKEIGG-TSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLL-AMG 95
Cdd:cd17341 1 LHLSWLSFFLGFMvwFLFAPLGPVIRDDLGlSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 96 SYLFASTVFLLLAVRILHGAGfGITTTTYGTVVSDLIPQAR-RGEGMGYFGL--SGTIAMAL-GPLI---GLWLMQTYNF 168
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKiGGAAGGIAGAgnMGVAVSQLlAPLIagaIVFDGGFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 169 TILFLCALSCTIVSLILTKLL--QIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATE---VG 243
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFgdDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTrfgLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 244 IADISLFLFN-ALAIAVTRPFSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAA-----CYGSGFGAIQPA 317
Cdd:cd17341 240 LVTAGILAALfPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFlalfvALGLGAGAGNGS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446425409 318 LQAwMIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTnYATVYRYSSLLLIAFLFIYIT 382
Cdd:cd17341 320 VFR-MVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMT-GSGVGAFSLFGVLAVACTLLV 382
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
18-116 |
8.10e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 38.06 E-value: 8.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 18 VALILANLCmflgFQMLIPTLPVYVKEiggtSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGSY 97
Cdd:cd17383 6 IALLLDNML----YMVIVPIIPDYLNE----DIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVF 77
|
90
....*....|....*....
gi 446425409 98 LFASTVFLLLAVRILHGAG 116
Cdd:cd17383 78 AFGESYAVLFFARSLQGVG 96
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
17-189 |
8.21e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.02 E-value: 8.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILANLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFVVGMFTVAALFVRPLTGNALQKFSKKIILMIGTAICLLAMGS 96
Cdd:cd17312 5 FLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 97 YLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYNF-TILFLCA 175
Cdd:cd17312 85 MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWrAAFLVPG 164
|
170
....*....|....
gi 446425409 176 LSCTIVSLILTKLL 189
Cdd:cd17312 165 IVGLVVAIILFFFL 178
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
263-359 |
8.72e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.11 E-value: 8.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 263 FSGKLYDAKGHSFVIIPGVIITFAGIILLSYTTTIPSLIIAAACYGSGFGAIQPALQAWMIDRVAPHRRGVATATFFSAF 342
Cdd:TIGR00895 71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGY 150
|
90
....*....|....*...
gi 446425409 343 DLGIGAGAIIFGF-IAHF 359
Cdd:TIGR00895 151 PIGAAVGGFLAGWlIPVF 168
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
17-361 |
9.52e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 37.67 E-value: 9.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 17 FVALILAnLCMFLGFQMLIPTLPVYVKEIGGTSSNIGFV-----VGMFTVAALFVRPLTGNALQKFskkiiLMIGTAICL 91
Cdd:cd06180 2 AGALALA-VAMGIGRFAYTPLLPLMLAELGLSYAQAGWIatanyAGYLVGALLASFLRRRGRARRL-----IRGGLLLTV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 92 LAMGSYLFASTVFLLLAVRILHGAGFGITTTTYGTVVSDLIPQARRGEGMGYFGLSGTIAMALGPLIGLWLMQTYN---- 167
Cdd:cd06180 76 LLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLswra 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 168 -FTILFLCALSCTIVSLILtkllqIKKSPQPPKQTSGTFLDGFIERKALLPSLLILCITLMYGGIGSFITLFATEVGIAD 246
Cdd:cd06180 156 gWLALALLSAVLLLLSFLL-----LRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425409 247 ISLFLFNA---LAIAVTRPFSGKLYDAKG--HSFVIIPGVIITFAGIILLSYTTTipSLIIAAACYGSGFGAIqPALQAW 321
Cdd:cd06180 231 LLAGLLWSlfgLAAVPSCFLWGALSDRWGtrRALAANLLVQAVGVLLPLLSPGPA--GLVLSAVLFGGTFMAI-TALVMA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446425409 322 MIDRVAPHRRGVATATFFSAFDLGIGAGAIIFGFIAHFTN 361
Cdd:cd06180 308 LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATG 347
|
|
| |
