NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446438903|ref|WP_000516758|]
View 

MULTISPECIES: Hsp20/alpha crystallin family protein [Bacillus]

Protein Classification

Hsp20/alpha crystallin family protein( domain architecture ID 10157978)

Hsp20/alpha crystallin family protein is a small, stress-induced protein, between 12-43 kDa, which functions as an ATP-independent chaperone that prevents aggregation and protects against cell stress, induced by heat, osmotic, or acid shock

CATH:  2.60.40.790
Gene Ontology:  GO:0006950
PubMed:  10950306|11875128|16165157|11908065|7723051
SCOP:  4002439

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 39-111 2.16e-05

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


:

Pssm-ID: 107221  Cd Length: 88  Bit Score: 40.23  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446438903  39 DLCETEEEYILETDVQNV--------TEQNVLI----KKLETGLAICILHKNI---SLQRTIPLPTTIIYKKMLACLENG 103
Cdd:cd06464    1 DVYETDDAYVVEADLPGFkkedikveVEDGVLTisgeREEEEEEEENYLRRERsygSFSRSFRLPEDVDPDKIKASLENG 80


                 ....*...
gi 446438903 104 FLAIHISK 111
Cdd:cd06464   81 VLTITLPK 88
 
Name Accession Description Interval E-value
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 39-111 2.16e-05

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 40.23  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446438903  39 DLCETEEEYILETDVQNV--------TEQNVLI----KKLETGLAICILHKNI---SLQRTIPLPTTIIYKKMLACLENG 103
Cdd:cd06464    1 DVYETDDAYVVEADLPGFkkedikveVEDGVLTisgeREEEEEEEENYLRRERsygSFSRSFRLPEDVDPDKIKASLENG 80


                 ....*...
gi 446438903 104 FLAIHISK 111
Cdd:cd06464   81 VLTITLPK 88
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 38-115 8.90e-05

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 38.98  E-value: 8.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446438903  38 IDLCETEEEYILETDVQNVTEQNVLIKKLETGLAIC-------------ILHKNI---SLQRTIPLPTTIIYKKMLACLE 101
Cdd:COG0071    2 VDIEETDDAYVITADLPGVDKEDIDVTVEGNVLTISgerkeeeeeegenYLRRERrygSFERSFTLPDDVDVDKIEASYE 81

                         90
                 ....*....|....
gi 446438903 102 NGFLAIHISKNEVA 115
Cdd:COG0071   82 NGVLTITLPKAEEA 95
 
Name Accession Description Interval E-value
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 39-111 2.16e-05

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 40.23  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446438903  39 DLCETEEEYILETDVQNV--------TEQNVLI----KKLETGLAICILHKNI---SLQRTIPLPTTIIYKKMLACLENG 103
Cdd:cd06464    1 DVYETDDAYVVEADLPGFkkedikveVEDGVLTisgeREEEEEEEENYLRRERsygSFSRSFRLPEDVDPDKIKASLENG 80


                 ....*...
gi 446438903 104 FLAIHISK 111
Cdd:cd06464   81 VLTITLPK 88
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 38-115 8.90e-05

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 38.98  E-value: 8.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446438903  38 IDLCETEEEYILETDVQNVTEQNVLIKKLETGLAIC-------------ILHKNI---SLQRTIPLPTTIIYKKMLACLE 101
Cdd:COG0071    2 VDIEETDDAYVITADLPGVDKEDIDVTVEGNVLTISgerkeeeeeegenYLRRERrygSFERSFTLPDDVDVDKIEASYE 81

                         90
                 ....*....|....
gi 446438903 102 NGFLAIHISKNEVA 115
Cdd:COG0071   82 NGVLTITLPKAEEA 95
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 42-111 8.69e-04

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 35.64  E-value: 8.69e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446438903  42 ETEEEYILETDVQNVTEQNVLIKKLETGLAICILHKNI--------SLQRTIPLPTTIIYKKMLACLENGFLAIHISK 111
Cdd:cd00298    3 QTDDEVVVTVDLPGVKKEDIKVEVEDNVLTISGKREEEeerersygEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH