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Conserved domains on  [gi|446450291|ref|WP_000528146|]
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MULTISPECIES: branched-chain-amino-acid transaminase [Bacillus]

Protein Classification

branched-chain-amino-acid transaminase( domain architecture ID 10793669)

branched-chain-amino-acid transaminase is a class IV aminotransferase and a pyridoxaL 5'-phosphate dependent enzyme (PLPDE) that catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids

EC:  2.6.1.42
Gene Symbol:  ilvE
Gene Ontology:  GO:0004084|GO:0030170
PubMed:  31989227|29523060

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
1-299 0e+00

branched-chain-amino-acid transaminase;


:

Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 621.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   1 MGNQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTL 80
Cdd:PRK12479   1 MGNQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEAVLQTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNV 160
Cdd:PRK12479  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYV 240
Cdd:PRK12479 161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446450291 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRERGVRVPGLAESLA 299
Cdd:PRK12479 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKQLTEEFKKLTRERGVRVPGLAESLL 299
 
Name Accession Description Interval E-value
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
1-299 0e+00

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 621.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   1 MGNQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTL 80
Cdd:PRK12479   1 MGNQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEAVLQTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNV 160
Cdd:PRK12479  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYV 240
Cdd:PRK12479 161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446450291 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRERGVRVPGLAESLA 299
Cdd:PRK12479 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKQLTEEFKKLTRERGVRVPGLAESLL 299
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
5-287 1.87e-137

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 389.93  E-value: 1.87e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   5 YIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNE 84
Cdd:COG0115    2 LIWLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVAANG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  85 YADAYIRLIVSRGKGDLGLDPrSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALdPRIKSMNYLNNVLVKI 164
Cdd:COG0115   82 LEDGYIRPQVTRGVGGRGVFA-EEYEPTVIIIASPLPAYPAEAYEKGVRVITSPYRRAAPGGL-GGIKTGNYLNNVLAKQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 165 EAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEV 244
Cdd:COG0115  160 EAKEAGADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPISLEELYTADEV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446450291 245 FLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRER 287
Cdd:COG0115  240 FLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYTDIVRGE 282
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
7-280 4.27e-135

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 383.10  E-value: 4.27e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   7 YMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNE-- 84
Cdd:cd01558    1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNEgg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  85 YADAYIRliVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNtpdaLDPRIKSMNYLNNVLVKI 164
Cdd:cd01558   81 EGDVYIQ--VTRGVGPRGHDFPKCVKPTVVIITQPLPLPPAELLEKGVRVITVPDIRW----LRCDIKSLNLLNNVLAKQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 165 EAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEV 244
Cdd:cd01558  155 EAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDNGILPGITRATVIELAKELGIPVEERPFSLEELYTADEV 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446450291 245 FLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEF 280
Cdd:cd01558  235 FLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
7-287 2.01e-122

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 352.05  E-value: 2.01e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291    7 YMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSY----GGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQK 82
Cdd:TIGR01122   1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYdtdkGPAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   83 NEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIA-EQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSM-NYLNNV 160
Cdd:TIGR01122  81 NNLRSAYIRPLVFRGDGDLGLNPRAGYKPDVIIAAwPWGAYLGEEALEKGIDAKVSSWRRNAPNTIPTAAKAGgNYLNSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYV 240
Cdd:TIGR01122 161 LAKSEARRHGYDEAILLDVEGYVAEGSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQPISREELYT 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 446450291  241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRER 287
Cdd:TIGR01122 241 ADEAFFTGTAAEITPIREVDGRKIGNGRRGPVTKKLQEAFFDLVTGG 287
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
32-259 4.34e-69

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 213.76  E-value: 4.34e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   32 GVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNEYADAYIRLIVSRGKGDLGLDPRScvkP 111
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVGRLRLTVSRGPGGFGLPTSD---P 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  112 SVIIIaeqLKLFPQEFYDNGLSVVSVASRRNTPdALDPRIKSMNYLNNVLVKIEAAQAGVLEALMLNQQGYVCEGSGDNV 191
Cdd:pfam01063  78 TLAIF---VSALPPPPESKKKGVISSLVRRNPP-SPLPGAKTLNYLENVLARREAKAQGADDALLLDEDGNVTEGSTSNV 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446450291  192 FIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTAAELIPVVKV 259
Cdd:pfam01063 154 FLVKGGTLYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
 
Name Accession Description Interval E-value
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
1-299 0e+00

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 621.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   1 MGNQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTL 80
Cdd:PRK12479   1 MGNQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEAVLQTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNV 160
Cdd:PRK12479  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYV 240
Cdd:PRK12479 161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446450291 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRERGVRVPGLAESLA 299
Cdd:PRK12479 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKQLTEEFKKLTRERGVRVPGLAESLL 299
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
4-289 0e+00

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 532.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   4 QYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKN 83
Cdd:PRK08320   3 QLIYLNGEFVPKEEAKVSVFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIMLEIPLSKEEMTEIVLETLRKN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  84 EYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNVLVK 163
Cdd:PRK08320  83 NLRDAYIRLVVSRGVGDLGLDPRKCPKPTVVCIAEPIGLYPGELYEKGLKVITVSTRRNRPDALSPQVKSLNYLNNILAK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 164 IEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADE 243
Cdd:PRK08320 163 IEANLAGVDEAIMLNDEGYVAEGTGDNIFIVKNGKLITPPTYAGALEGITRNAVIEIAKELGIPVREELFTLHDLYTADE 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 446450291 244 VFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRERGV 289
Cdd:PRK08320 243 VFLTGTAAEVIPVVKVDGRVIGDGKPGPITKKLLEEFRELTKKDGT 288
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
5-287 1.87e-137

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 389.93  E-value: 1.87e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   5 YIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNE 84
Cdd:COG0115    2 LIWLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVAANG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  85 YADAYIRLIVSRGKGDLGLDPrSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALdPRIKSMNYLNNVLVKI 164
Cdd:COG0115   82 LEDGYIRPQVTRGVGGRGVFA-EEYEPTVIIIASPLPAYPAEAYEKGVRVITSPYRRAAPGGL-GGIKTGNYLNNVLAKQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 165 EAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEV 244
Cdd:COG0115  160 EAKEAGADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPISLEELYTADEV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446450291 245 FLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRER 287
Cdd:COG0115  240 FLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYTDIVRGE 282
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
7-280 4.27e-135

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 383.10  E-value: 4.27e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   7 YMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNE-- 84
Cdd:cd01558    1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNEgg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  85 YADAYIRliVSRGKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNtpdaLDPRIKSMNYLNNVLVKI 164
Cdd:cd01558   81 EGDVYIQ--VTRGVGPRGHDFPKCVKPTVVIITQPLPLPPAELLEKGVRVITVPDIRW----LRCDIKSLNLLNNVLAKQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 165 EAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEV 244
Cdd:cd01558  155 EAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDNGILPGITRATVIELAKELGIPVEERPFSLEELYTADEV 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446450291 245 FLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEF 280
Cdd:cd01558  235 FLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
7-287 2.01e-122

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 352.05  E-value: 2.01e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291    7 YMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSY----GGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQK 82
Cdd:TIGR01122   1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYdtdkGPAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   83 NEYADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIA-EQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSM-NYLNNV 160
Cdd:TIGR01122  81 NNLRSAYIRPLVFRGDGDLGLNPRAGYKPDVIIAAwPWGAYLGEEALEKGIDAKVSSWRRNAPNTIPTAAKAGgNYLNSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  161 LVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYV 240
Cdd:TIGR01122 161 LAKSEARRHGYDEAILLDVEGYVAEGSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQPISREELYT 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 446450291  241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRER 287
Cdd:TIGR01122 241 ADEAFFTGTAAEITPIREVDGRKIGNGRRGPVTKKLQEAFFDLVTGG 287
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
24-280 4.90e-113

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 326.87  E-value: 4.90e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  24 DHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNEYADAYIRLIVSRGKGDLGL 103
Cdd:cd00449    1 DRGLHYGDGVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELVAANNGASLYIRPLLTRGVGGLGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 104 DPRSCVKPSVIIIAEQLKLfPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNVLVKIEAAQAGVLEALMLNQQGYV 183
Cdd:cd00449   81 APPPSPEPTFVVFASPVGA-YAKGGEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEAGADEALLLDDNGYV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 184 CEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTAAELIPVVKVDSRE 263
Cdd:cd00449  160 TEGSASNVFIVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRG 239
                        250
                 ....*....|....*..
gi 446450291 264 IGDGKPGSVTKRLTEEF 280
Cdd:cd00449  240 IGDGKPGPVTRKLRELL 256
PRK06606 PRK06606
branched-chain amino acid transaminase;
5-287 9.19e-107

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 312.85  E-value: 9.19e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   5 YIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSY----GGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTL 80
Cdd:PRK06606   8 YIWFNGELVPWEDAKVHVLTHALHYGTGVFEGIRAYdtpkGPAIFRLREHTKRLFNSAKILRMEIPYSVDELMEAQREVV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  81 QKNEYADAYIRLIVSRGKGDLGLDPRSCvKPSVIIIAeqlklFP------QEFYDNGLSVVSVASRRNTPDALDPRIK-S 153
Cdd:PRK06606  88 RKNNLKSAYIRPLVFVGDEGLGVRPHGL-PTDVAIAA-----WPwgaylgEEALEKGIRVKVSSWTRHAPNSIPTRAKaS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 154 MNYLNNVLVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPF 233
Cdd:PRK06606 162 GNYLNSILAKTEARRNGYDEALLLDVEGYVSEGSGENIFIVRDGVLYTPPLTSSILEGITRDTVITLAKDLGIEVIERRI 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446450291 234 TRHDVYVADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKKLTRER 287
Cdd:PRK06606 242 TRDELYIADEVFFTGTAAEVTPIREVDGRQIGNGKRGPITEKLQSAYFDIVRGR 295
PRK07650 PRK07650
4-amino-4-deoxychorismate lyase; Provisional
5-284 6.65e-75

4-amino-4-deoxychorismate lyase; Provisional


Pssm-ID: 181067  Cd Length: 283  Bit Score: 230.62  E-value: 6.65e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   5 YIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNE 84
Cdd:PRK07650   1 LIYVNGQYVEEEEARISPFDHGYLYGLGVFETFRIYNGHPFLLDDHYDRLNDALDTLQIEWTMTKDEVLLILKNLLEKNG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  85 YADAYIRLIVSRGKGDLGLDPRSCVKPSVIIIAEQLKlfPQEFYDNGLSVVsVASRRNTPDAlDPRIKSMNYLNNVLVKI 164
Cdd:PRK07650  81 LENAYVRFNVSAGIGEIGLQTEMYEEPTVIVYMKPLA--PPGLPAEKEGVV-LKQRRNTPEG-AFRLKSHHYLNNILGKR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 165 EAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEV 244
Cdd:PRK07650 157 EIGNDPNKEGIFLTEEGYVAEGIVSNLFWVKGDIVYTPSLETGILNGITRAFVIKVLEELGIEVKEGFYTKEELLSADEV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446450291 245 FLTGTAAELIPVVKVDSREIgDGKPGSVTKRLTEEFKKLT 284
Cdd:PRK07650 237 FVTNSIQEIVPLTRIEERDF-PGKVGMVTKRLQNLYEMQR 275
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
24-280 8.92e-75

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 229.12  E-value: 8.92e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  24 DHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPvEEMEEAVLQTLQKNEYADAYIRLIVSRGKGDLGL 103
Cdd:cd01559    1 DRGFAYGDGVFETMRALDGRLFLLDAHLARLERSARRLGIPEPDL-PRLRAALESLLAANDIDEGRIRLILSRGPGGRGY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 104 DPRSCVKPSVIIIAEQLKLFPQEfydNGLSVVSVASRRNTPDALdPRIKSMNYLNNVLVKIEAAQAGVLEALMLNQQGYV 183
Cdd:cd01559   80 APSVCPGPALYVSVIPLPPAWRQ---DGVRLITCPVRLGEQPLL-AGLKHLNYLENVLAKREARDRGADEALFLDTDGRV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 184 CEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTAAELIPVVKVDSRe 263
Cdd:cd01559  156 IEGTASNLFFVKDGELVTPSLDRGGLAGITRQRVIELAAAKGYAVDERPLRLEDLLAADEAFLTNSLLGVAPVTAIDDH- 234
                        250
                 ....*....|....*..
gi 446450291 264 igDGKPGSVTKRLTEEF 280
Cdd:cd01559  235 --DGPPGPLTRALRELL 249
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
32-259 4.34e-69

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 213.76  E-value: 4.34e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   32 GVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNEYADAYIRLIVSRGKGDLGLDPRScvkP 111
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVGRLRLTVSRGPGGFGLPTSD---P 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  112 SVIIIaeqLKLFPQEFYDNGLSVVSVASRRNTPdALDPRIKSMNYLNNVLVKIEAAQAGVLEALMLNQQGYVCEGSGDNV 191
Cdd:pfam01063  78 TLAIF---VSALPPPPESKKKGVISSLVRRNPP-SPLPGAKTLNYLENVLARREAKAQGADDALLLDEDGNVTEGSTSNV 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446450291  192 FIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTAAELIPVVKV 259
Cdd:pfam01063 154 FLVKGGTLYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
20-285 5.45e-64

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 202.81  E-value: 5.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  20 VSVYDHGFLYGDGVFEGIRSY-----GGNVFCLKEHVKRLYESAKSILLTiPMPVEEMEEAVLQTLQKNEY-------AD 87
Cdd:cd01557    2 LHPATHALHYGQAVFEGLKAYrtpdgKIVLFRPDENAERLNRSARRLGLP-PFSVEEFIDAIKELVKLDADwvpygggAS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  88 AYIRLIVSRGKGDLGLDPRSCVKpsVIIIAEQL-KLFPQEFydNGLSVVSVASRRNtpdalDPRIKSM-----NYLNNVL 161
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYL--FAVFASPVgAYFKGGE--KGVSALVSSFRRA-----APGGPGAakaggNYAASLL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 162 VKIEAAQAGVLEALMLN-QQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYV 240
Cdd:cd01557  152 AQKEAAEKGYDQALWLDgAHGYVAEVGTMNIFFVKDGELITPPLDGSILPGITRDSILELARDLGIKVEERPITRDELYE 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 446450291 241 ADEVFLTGTAAELIPVVKVDSREI--GDGKPGSVTKRLTEEFKKLTR 285
Cdd:cd01557  232 ADEVFATGTAAVVTPVGEIDYRGKepGEGEVGPVTKKLYDLLTDIQY 278
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
3-280 2.07e-63

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 201.31  E-value: 2.07e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   3 NQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQK 82
Cdd:PRK06680   2 KRIAYVNGRYVNHREARVHIEDRGFQFADGIYEVCAVRDGKLVDLDRHLARLFRSLGEIRIAPPMTRAELVEVLRELIRR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  83 NEYADAYIRLIVSRGKGDLG-LDPRSCVKPSVIIIAEQLKLF-PQEFYDNGLSVVSVasrrntPDALDPR--IKSMNYLN 158
Cdd:PRK06680  82 NRVREGLVYLQVTRGVARRDhVFPAADVKPSVVVFAKSVDFArPAAAAETGIKVITV------PDNRWKRcdIKSVGLLP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 159 NVLVKIEAAQAGVLEALMLnQQGYVCEGSGDNVFIV-KDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHD 237
Cdd:PRK06680 156 NVLAKQAAKEAGAQEAWMV-DDGFVTEGASSNAWIVtKDGKLVTRPADNFILPGITRHTLIDLAKELGLEVEERPFTLQE 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446450291 238 VYVADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEF 280
Cdd:PRK06680 235 AYAAREAFITAASSFVFPVVQIDGKQIGNGKPGPIAKRLREAY 277
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
5-287 1.13e-57

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 187.11  E-value: 1.13e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   5 YIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNE 84
Cdd:PRK07544  10 FIWMDGELVPWRDAKVHVLTHGLHYASSVFEGERAYGGKIFKLREHSERLRRSAELLDFEIPYSVAEIDAAKKETLAANG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  85 YADAYIRLIVSRGKGDLGLDPRScVKPSVIIIA-EQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMN-YLNNVLV 162
Cdd:PRK07544  90 LTDAYVRPVAWRGSEMMGVSAQQ-NKIHLAIAAwEWPSYFDPEAKMKGIRLDIAKWRRPDPETAPSAAKAAGlYMICTIS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 163 KIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTP-PSYLgaLEGITRNSVIELCERLNISCEERPFTRHDVYVA 241
Cdd:PRK07544 169 KHAAEAKGYADALMLDYRGYVAEATGANIFFVKDGVIHTPtPDCF--LDGITRQTVIELAKRRGIEVVERHIMPEELAGF 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 446450291 242 DEVFLTGTAAELIPVvkvdsREIGDGK--PGSVTKRLTEEFKKLTRER 287
Cdd:PRK07544 247 SECFLTGTAAEVTPV-----SEIGEYRftPGAITRDLMDDYEALVRPR 289
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
4-282 5.45e-46

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 156.72  E-value: 5.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   4 QYIYMNGEFVE--KEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQ 81
Cdd:PRK12400   5 RFVLWNDAVIDttKQKTYIELEERGLQFGDGVYEVIRLYKGNFHLLDPHITRLYRSMEEIELTLPFSKAELITLLYKLIE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  82 KNEY-ADAYIRLIVSRGkgdlgLDPRSCV----KPSVIIIAEQLKLFPQEFYDNGLSVVSvasrrnTPDA--LDPRIKSM 154
Cdd:PRK12400  85 NNNFhEDGTIYLQVSRG-----VQARTHTfsydVPPTIYAYITKKERPALWIEYGVRAIS------EPDTrwLRCDIKSL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 155 NYLNNVLVKIEAAQAGVLEALMLnQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFT 234
Cdd:PRK12400 154 NLLPNILAATKAERKGCKEALFV-RNGTVTEGSHSNFFLIKNGTLYTHPANHLILNGIIRQYVLSLAKTLRIPVQEELFS 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 446450291 235 RHDVYVADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTEEFKK 282
Cdd:PRK12400 233 VRDVYQADECFFTGTTIEILPMTHLDGTAIQDGQVGPITKMLQRSFSQ 280
PRK06092 PRK06092
4-amino-4-deoxychorismate lyase; Reviewed
20-283 2.11e-38

4-amino-4-deoxychorismate lyase; Reviewed


Pssm-ID: 235696  Cd Length: 268  Bit Score: 136.12  E-value: 2.11e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  20 VSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPV---EEMEEAVLQTlqkneyADAYIRLIVSR 96
Cdd:PRK06092  12 LSVSDRSTQYGDGCFTTARVRDGQVSLLSRHLQRLQDACERLAIPLDDWAqleQEMKQLAAEL------ENGVLKVIISR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  97 GKGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVsvASRrnTPDALDPR---IKSMNYLNNVLVKIEAAQAGVLE 173
Cdd:PRK06092  86 GSGGRGYSPAGCAAPTRILSVSPYPAHYSRWREQGITLA--LCP--TRLGRNPLlagIKHLNRLEQVLIRAELEQTEADE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 174 ALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTaaeL 253
Cdd:PRK06092 162 ALVLDSEGWVIECCAANLFWRKGGVVYTPDLDQCGVAGVMRQFILELLAQSGYPVVEVDASLEELLQADEVFICNS---L 238
                        250       260       270
                 ....*....|....*....|....*....|..
gi 446450291 254 IPVVKVdsREIGDGK--PGSVTKRLTEEFKKL 283
Cdd:PRK06092 239 MPVWPV--RAIGETSysSGTLTRYLQPLCERL 268
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
19-278 5.72e-38

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 137.07  E-value: 5.72e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  19 VVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQKNEYADAYIRLIVSRGK 98
Cdd:PLN02845  56 VIPLDDHMVHRGHGVFDTATIRDGHLYELDAHLDRFLRSAAKAKIPLPFDRATLRRILLQTVAASGCRNGSLRYWLSAGP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  99 GDLGLDPRSCVKPS--VIIIAEQLKLFPQEfydnGLSVVSvASRRNTPdaldPR---IKSMNYLNNVLVKIEAAQAGVLE 173
Cdd:PLN02845 136 GGFSLSPSGCSEPAfyAVVIEDTYAQDRPE----GVKVVT-SSVPIKP----PQfatVKSVNYLPNALSQMEAEERGAFA 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 174 ALMLNQQGYVCEGSGDNV-FIVKDGKVLTPPsYLGALEGITRNSVIELCERL------------NISCEErpftrhdVYV 240
Cdd:PLN02845 207 GIWLDEEGFVAEGPNMNVaFLTNDGELVLPP-FDKILSGCTARRVLELAPRLvspgdlrgvkqrKISVEE-------AKA 278
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446450291 241 ADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKRLTE 278
Cdd:PLN02845 279 ADEMMLIGSGVPVLPIVSWDGQPIGDGKVGPITLALHD 316
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
3-275 2.25e-30

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 115.44  E-value: 2.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   3 NQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPMPVEEMEEAVLQTLQK 82
Cdd:PRK13356   6 NTWTFFDGEWHEGNVPIMGPADHAAWLGSTVFDGARAFEGVTPDLDLHCARVNRSAEALGLKPTVSAEEIEALAREGLKR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  83 -NEYADAYIRLIVSRGKGDLGldprscvkpSVIIIAEQ----LKLF----PQefyDNGLSVVSVASRRNTPDALDPRIK- 152
Cdd:PRK13356  86 fDPDTALYIRPMYWAEDGFAS---------GVAPDPEStrfaLCLEeapmPE---PTGFSLTLSPFRRPTLEMAPTDAKa 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 153 SMNYLNNVLVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERP 232
Cdd:PRK13356 154 GCLYPNNARALREARSRGFDNALVLDMLGNVAETATSNVFMVKDGVVFTPVPNGTFLNGITRQRVIALLREDGVTVVETT 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446450291 233 FTRHDVYVADEVFLTGTAAELIPVVKVDSREIgdgKPGSVTKR 275
Cdd:PRK13356 234 LTYEDFLEADEVFSTGNYSKVVPVTRFDDRSL---QPGPVTRR 273
PRK07849 PRK07849
aminodeoxychorismate lyase;
9-265 3.41e-23

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 96.57  E-value: 3.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291   9 NGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKsiLLTIPMPVEE-MEEAVLQTLQK--NEY 85
Cdd:PRK07849  17 SERVHDPSAPLLHADDLAAVRGDGVFETLLVRDGRPCNLEAHLERLARSAA--LLDLPEPDLDrWRRAVELAIEEwrAPE 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  86 ADAYIRLIVSRGKGDLGldprscvKPSVIIIAEQLKLFPQEFYDNGLSVVSvASRRNTPDALDPR------IKSMNYLNN 159
Cdd:PRK07849  95 DEAALRLVYSRGRESGG-------APTAWVTVSPVPERVARARREGVSVIT-LDRGYPSDAAERApwllagAKTLSYAVN 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 160 VLVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVY 239
Cdd:PRK07849 167 MAALRYAARRGADDVIFTSTDGYVLEGPTSTVVIATDDRLLTPPPWYGILPGTTQAALFEVAREKGWDCEYRALRPADLF 246
                        250       260
                 ....*....|....*....|....*.
gi 446450291 240 VADEVFLTGTAAELIPVVKVDSREIG 265
Cdd:PRK07849 247 AADGVWLVSSVRLAARVHTLDGRPLP 272
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
29-279 1.42e-19

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 87.51  E-value: 1.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  29 YGDGVFEGIRSY----GG-NVFCLKEHVKRLYESAKSILLTiPMPVEEMEEAVLQTLQKNE-----YADA---YIR--LI 93
Cdd:PRK13357  64 YGQEIFEGLKAYrhkdGSiVLFRPDANAKRLQRSADRLLMP-ELPEELFLEAVKQLVKADRdwvppYGEGaslYLRpfMI 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  94 vsrGKGD-LGldprscVKPS----VIIIAEqlklfPQE-FYDNGLSVVSV--------ASRRNTPDAldpriKSM-NYLN 158
Cdd:PRK13357 143 ---ATEPfLG------VKPAeeyiFCVIAS-----PVGaYFKGGVKPVSIwvsdeydrAAPGGTGAA-----KVGgNYAA 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 159 NVLVKIEAAQAGVLEALML--NQQGYVCEGSGDNVF-IVKDGKVLTPPSylGA-LEGITRNSVIELCERLNISCEERPFT 234
Cdd:PRK13357 204 SLLAQAEAKEKGCDQVLYLdaVEHTYIEEVGGMNFFfITKDGTVTPPLS--GSiLPGITRDSLLQLAEDLGLTVEERPVS 281
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446450291 235 ----RHDVYVAD--EVFLTGTAAELIPVVKVDSRE----IGDGKPGSVTKRLTEE 279
Cdd:PRK13357 282 idewQADAASGEftEAFACGTAAVITPIGGIKYKDkefvIGDGEVGPVTQKLYDE 336
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
29-276 1.40e-17

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 82.20  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  29 YGDGVFEGIRSY---GGNV--FCLKEHVKRLYESAKSILLTIPMpVEEMEEAVLQTLQKNEyadayiRLIVSRGKGDLgl 103
Cdd:PLN02782 118 YGQGLFEGLKAYrkeDGNIllFRPEENAIRMRNGAERMCMPAPT-VEQFVEAVKETVLANK------RWVPPPGKGSL-- 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 104 dprsCVKPSVIIIAEQLKLFPQ-------------EFYDNGLS----VVSVASRRNTPDALDPrIKSM-NYLNNVLVKIE 165
Cdd:PLN02782 189 ----YIRPLLMGSGAVLGLAPApeytfliyvspvgNYFKEGVApinlIVENEFHRATPGGTGG-VKTIgNYAAVLKAQSI 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 166 AAQAGVLEALMLN--QQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADE 243
Cdd:PLN02782 264 AKAKGYSDVLYLDcvHKKYLEEVSSCNIFIVKDNVISTPAIKGTILPGITRKSIIDVARSQGFQVEERNVTVDELLEADE 343
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 446450291 244 VFLTGTAAELIPVVKVDSR----EIGDGKPGSVTKRL 276
Cdd:PLN02782 344 VFCTGTAVVVSPVGSITYKgkrvSYGEGGFGTVSQQL 380
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
29-259 1.57e-15

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 75.74  E-value: 1.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  29 YGDGVFEGIRSYGGN-----VFCLKEHVKRLYESAKSILLTIPMPvEEMEEAVLQTLQKNEyadayiRLIVSRGKGDLgl 103
Cdd:PLN03117  68 YGQGLFEGLKAYRTEdgritLFRPDQNALRMQTGADRLCMTPPSL-EQFVEAVKQTVLANK------KWVPPPGKGTL-- 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 104 dprsCVKPSVIIIAEQLKLFPQEFY---------------DNGLSV-VSVASRRNTPDALDPRIKSMNYLNNVLVKIEAA 167
Cdd:PLN03117 139 ----YIRPLLIGSGAVLGVAPAPEYtfliyaspvgnyhkaSSGLNLkVDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAK 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 168 QAGVLEALMLNQQG--YVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVF 245
Cdd:PLN03117 215 SSGFSDVLFLDAATgkNIEELSACNIFILKGNIVSTPPTSGTILPGVTRKSISELARDIGYQVEERDVSVDELLEAEEVF 294
                        250
                 ....*....|....
gi 446450291 246 LTGTAAELIPVVKV 259
Cdd:PLN03117 295 CTGTAVVVKAVETV 308
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
29-256 2.25e-11

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 63.59  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  29 YGDGVFEGIRSY---GGNVFCLK--EHVKRLYESAKSILLTIPmPVEEMEEAVLQTLQKNEY-------ADAYIRLIVSR 96
Cdd:PLN02259 104 YGQAIYEGTKAYrkeNGKLLLFRpdHNAIRMKLGAERMLMPSP-SVDQFVNAVKQTALANKRwvppagkGTLYIRPLLMG 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  97 GKGDLGLDPRScvKPSVIIIAEQLKlfpqEFYDNGLSVVSVASR----RNTPDALDPrIKSMNYLNNVLVKIEAAQA-GV 171
Cdd:PLN02259 183 SGPILGLGPAP--EYTFIVYASPVG----NYFKEGMAALNLYVEeeyvRAAPGGAGG-VKSITNYAPVLKALSRAKSrGF 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 172 LEALMLN--QQGYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGT 249
Cdd:PLN02259 256 SDVLYLDsvKKKYLEEASSCNVFVVKGRTISTPATNGTILEGITRKSVMEIASDQGYQVVEKAVHVDEVMDADEVFCTGT 335

                 ....*..
gi 446450291 250 AAELIPV 256
Cdd:PLN02259 336 AVVVAPV 342
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
29-267 2.30e-11

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 63.58  E-value: 2.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  29 YGDGVFEGIRSYGGN-----VFCLKEHVKRLYESAKSILLTIPmPVEEMEEAVLQTLQKNEyadayiRLIVSRGKGDLGL 103
Cdd:PLN02883 100 YGQGLIEGMKAYRGEdgrilLFRPELNAMRMKIGAERMCMHSP-SVHQFIEGVKQTVLANR------RWVPPPGKGSLYL 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 104 DPR---SCVKPSVIIIAEQLKLF----PQEFYDNGLSVVSVASRRNTPDAL---DPRIKSMNYLNNVLVKIEAAQA-GVL 172
Cdd:PLN02883 173 RPLlfgSGASLGVAAAPEYTFLVfgspVQNYFKEGTAALNLYVEEVIPRAYlggTGGVKAISNYGPVLEVMRRAKSrGFS 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 173 EALMLNQQ--GYVCEGSGDNVFIVKDGKVLTPPSYLGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTA 250
Cdd:PLN02883 253 DVLYLDADtgKNIEEVSAANIFLVKGNIIVTPATSGTILGGITRKSIIEIALDLGYKVEERRVPVEELKEAEEVFCTGTA 332
                        250       260
                 ....*....|....*....|...
gi 446450291 251 AELIPVVKVDSR------EIGDG 267
Cdd:PLN02883 333 AGVASVGSITFKntrteyKVGDG 355
PRK07546 PRK07546
hypothetical protein; Provisional
165-257 8.24e-08

hypothetical protein; Provisional


Pssm-ID: 169002 [Multi-domain]  Cd Length: 209  Bit Score: 51.52  E-value: 8.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 165 EAAQAGVLEALMLNQQGYVCEGSGDNVFI-VKDGKVLTPPSYLGALEGITRNSVieLCERlniSCEERPFTRHDVYVADE 243
Cdd:PRK07546 119 ELPPAEADEVILLNERGEVCEGTITNVFLdRGGGMLTTPPLSCGLLPGVLRAEL--LDAG---RAREAVLTVDDLKSARA 193
                         90
                 ....*....|....
gi 446450291 244 VFLTGTAAELIPVV 257
Cdd:PRK07546 194 IWVGNSLRGLIRAE 207
PRK09266 PRK09266
hypothetical protein; Provisional
28-269 2.90e-05

hypothetical protein; Provisional


Pssm-ID: 236438  Cd Length: 266  Bit Score: 44.59  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291  28 LYGDGVFEGIRSYGGNVFCLKEHVKRLyESAKSILLTIPMPVEEMEEAVLQTLQkNEYADAYIRLIVSRGKGDLGlDPRS 107
Cdd:PRK09266  22 LANYGHFTSMQVRDGRVRGLDLHLQRL-RRASRELFGAALDDDRVRAQLRAALA-AGPADASVRVTVFAPDFDFR-NPLA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 108 CVKPSVII-IAEqlklfPQEFYDNGLSVVSVASRRNTPDaldprIKSMNYLNNVLVKIEAAQAGVLEALMLNQQGYVCEG 186
Cdd:PRK09266  99 DVAPDVLVaTSP-----PADGPAGPLRLQSVPYERELPH-----IKHVGTFGQLHLRRLAQRAGFDDALFVDPDGRVSEG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450291 187 SGDNVFIVKDGKVLTPPSylGALEGITRNSVIELCERLNISCEERPFTRHDVYVADEVFLTGTAAELIPVVKVDSREIGD 266
Cdd:PRK09266 169 ATWNLGFWDGGAVVWPQA--PALPGVTMALLQRGLERLGIPQRTRPVTLADLGRFAGAFACNAWRGQRAVSAIDDVALPD 246

                 ...
gi 446450291 267 GKP 269
Cdd:PRK09266 247 SHA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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