NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446503621|ref|WP_000581475|]
View 

MULTISPECIES: VOC family protein [Bacillus]

Protein Classification

VOC family protein( domain architecture ID 10163559)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms; similar to type I extradiol dioxygenase, glyoxalase I and a group of antibiotic resistance proteins such as Staphylococcus aureus bleomycin resistance protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 7-124 4.24e-54

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


:

Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 165.16  E-value: 4.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   7 QIMLYVNNQDEAVNFWTEKVGFHVVAEEDNkQGMRWIEIAPTNGAETSIILHNKEVISKM--SPELNLGTPSLMFFSENL 84
Cdd:cd07263    1 QVMLYVDDQDKALDFYVEKLGFEVVEDVPM-GGMRWVTVAPPGSPGTSLLLEPKAHPAQMpqSPEAAGGTPGILLATDDI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446503621  85 DQLYAGLKNKNVTVGEMVT-MPSGKVFNFADSEGNYFAVME 124
Cdd:cd07263   80 DATYERLTAAGVTFVQEPTqMGGGRVANFRDPDGNLFALME 120
 
Name Accession Description Interval E-value
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 7-124 4.24e-54

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 165.16  E-value: 4.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   7 QIMLYVNNQDEAVNFWTEKVGFHVVAEEDNkQGMRWIEIAPTNGAETSIILHNKEVISKM--SPELNLGTPSLMFFSENL 84
Cdd:cd07263    1 QVMLYVDDQDKALDFYVEKLGFEVVEDVPM-GGMRWVTVAPPGSPGTSLLLEPKAHPAQMpqSPEAAGGTPGILLATDDI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446503621  85 DQLYAGLKNKNVTVGEMVT-MPSGKVFNFADSEGNYFAVME 124
Cdd:cd07263   80 DATYERLTAAGVTFVQEPTqMGGGRVANFRDPDGNLFALME 120
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-124 3.38e-15

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 66.58  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   1 MIHKVGQIMLYVNNQDEAVNFWTEKVGFHVVAEEDnkQGMRWIEIAPTNGAEtsiilhnkEVISKMSPELNLGTPSLMFF 80
Cdd:COG3324    1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAG--PGGDYAEFDTDGGQV--------GGLMPGAEEPGGPGWLLYFA 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446503621  81 SENLDQLYAGLKNKNVTV--GEMVTMPSGKVFNFADSEGNYFAVME 124
Cdd:COG3324   71 VDDLDAAVARVEAAGGTVlrPPTDIPPWGRFAVFRDPEGNRFGLWQ 116
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
4-122 7.45e-13

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 60.54  E-value: 7.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621    4 KVGQIMLYVNNQDEAVNFWTEKVGFHVVAEEDNKQGMRWIEIAPTNGAETSIILHNKEVISKMSPELNLGTPSLMFFSEN 83
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLVEETDAGEEGGLRSAFFLAGGRVLELLLNETPPPAAAGFGGHHIAFIAFSVDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446503621   84 LDQLYAGLKNKNVTV-GEMVTMPSG-KVFNFADSEGNYFAV 122
Cdd:pfam00903  81 VDAAYDRLKAAGVEIvREPGRHGWGgRYSYFRDPDGNLIEL 121
 
Name Accession Description Interval E-value
VOC_like cd07263
uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate ...
 7-124 4.24e-54

uncharacterized subfamily of vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping


Pssm-ID: 319924 [Multi-domain]  Cd Length: 120  Bit Score: 165.16  E-value: 4.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   7 QIMLYVNNQDEAVNFWTEKVGFHVVAEEDNkQGMRWIEIAPTNGAETSIILHNKEVISKM--SPELNLGTPSLMFFSENL 84
Cdd:cd07263    1 QVMLYVDDQDKALDFYVEKLGFEVVEDVPM-GGMRWVTVAPPGSPGTSLLLEPKAHPAQMpqSPEAAGGTPGILLATDDI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446503621  85 DQLYAGLKNKNVTVGEMVT-MPSGKVFNFADSEGNYFAVME 124
Cdd:cd07263   80 DATYERLTAAGVTFVQEPTqMGGGRVANFRDPDGNLFALME 120
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 1-124 3.38e-15

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 66.58  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   1 MIHKVGQIMLYVNNQDEAVNFWTEKVGFHVVAEEDnkQGMRWIEIAPTNGAEtsiilhnkEVISKMSPELNLGTPSLMFF 80
Cdd:COG3324    1 MPGTIVWVELPVDDLERAKAFYEEVFGWTFEDDAG--PGGDYAEFDTDGGQV--------GGLMPGAEEPGGPGWLLYFA 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446503621  81 SENLDQLYAGLKNKNVTV--GEMVTMPSGKVFNFADSEGNYFAVME 124
Cdd:COG3324   71 VDDLDAAVARVEAAGGTVlrPPTDIPPWGRFAVFRDPEGNRFGLWQ 116
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
4-122 7.45e-13

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 60.54  E-value: 7.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621    4 KVGQIMLYVNNQDEAVNFWTEKVGFHVVAEEDNKQGMRWIEIAPTNGAETSIILHNKEVISKMSPELNLGTPSLMFFSEN 83
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLVEETDAGEEGGLRSAFFLAGGRVLELLLNETPPPAAAGFGGHHIAFIAFSVDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446503621   84 LDQLYAGLKNKNVTV-GEMVTMPSG-KVFNFADSEGNYFAV 122
Cdd:pfam00903  81 VDAAYDRLKAAGVEIvREPGRHGWGgRYSYFRDPDGNLIEL 121
GloA COG0346
Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary ...
 4-124 1.97e-10

Catechol 2,3-dioxygenase or related enzyme, vicinal oxygen chelate (VOC) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440115 [Multi-domain]  Cd Length: 125  Bit Score: 54.23  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   4 KVGQIMLYVNNQDEAVNFWTEKVGFHVVAE---EDNKQGMRWIEIaptnGAETSIILHNKEVISKMSPELNLGTpsLMFF 80
Cdd:COG0346    2 GLHHVTLRVSDLEASLAFYTDVLGLELVKRtdfGDGGFGHAFLRL----GDGTELELFEAPGAAPAPGGGGLHH--LAFR 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446503621  81 SENLDQLYAGLKNKNVTV-GEMVTMPSG-KVFNFADSEGNYFAVME 124
Cdd:COG0346   76 VDDLDAAYARLRAAGVEIeGEPRDRAYGyRSAYFRDPDGNLIELVE 121
CatE COG2514
Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];
2-118 6.51e-08

Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442004 [Multi-domain]  Cd Length: 141  Bit Score: 48.03  E-value: 6.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   2 IHKVGQIMLYVNNQDEAVNFWTEKVGFHVVAEEDnkqGMRWIEIAptnGAETSIILHNKEviskmSPELNLGTPSLMFFS 81
Cdd:COG2514    1 ITRLGHVTLRVRDLERSAAFYTDVLGLEVVEREG---GRVYLRAD---GGEHLLVLEEAP-----GAPPRPGAAGLDHVA 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446503621  82 ------ENLDQLYAGLKNKNVTVGEMVTMPSGKVFNFADSEGN 118
Cdd:COG2514   70 frvpsrADLDAALARLAAAGVPVEGAVDHGVGESLYFRDPDGN 112
VOC cd06587
vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed ...
 8-120 3.49e-03

vicinal oxygen chelate (VOC) family; The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.


Pssm-ID: 319898 [Multi-domain]  Cd Length: 112  Bit Score: 34.81  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446503621   8 IMLYVNNQDEAVNFWTEKVGFHVVAEEDnkqGMRWIEIAPTNGAETSIILHNKEViskmsPELNLGTPSLMFFSENLDQL 87
Cdd:cd06587    2 VALRVPDLDASVAFYEEVLGFEVVSRNE---GGGFAFLRLGPGLRLALLEGPEPE-----RPGGGGLFHLAFEVDDVDEV 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446503621  88 YAGLK----NKNVTVGEMVTMPSGKVFNFADSEGNYF 120
Cdd:cd06587   74 DERLReagaEGELVAPPVDDPWGGRSFYFRDPDGNLI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH