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Conserved domains on  [gi|446518315|ref|WP_000595661|]
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MULTISPECIES: type VII secretion protein EssA [Bacillus]

Protein Classification

type VII secretion EssA family protein( domain architecture ID 10566396)

type VII secretion EssA family protein with similarity to Staphylococcus aureus ESAT-6 secretion machinery protein EssA, a component of the ESAT-6 secretion system (Ess) that is required for the secretion of EsxA and EsxB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EssA pfam10661
WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) ...
 25-167 4.92e-57

WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (pfam06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (pfam10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (pfam01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria.


:

Pssm-ID: 287614  Cd Length: 148  Bit Score: 175.46  E-value: 4.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446518315   25 IRSAADSYLGDDGKIKFKVDRLEESDQEKNKKEHKETELDKASIELFNQDIEEEIEKKKKKEQKDMEALRDSLFIKQKEN 104
Cdd:pfam10661   1 IGSAADSYLEDDGKMDFKVDRLIKDKQEKNEKQLRETELDKAFISLFTTETEEEINEKKKAEKKEMEDIEDSLFSEDKEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446518315  105 N-SVKDTKNSLFSSEYIVRKSADEVASNETMNEEPISIT----IILLFGGGILLICIGIYTVLRKSWR 167
Cdd:pfam10661  81 NvAVKDTKDSLFSSEYEVRASNTETASSETAEEESTSSTssniIIGLFAGGAVALCGGIYVLMRKLWE 148
 
Name Accession Description Interval E-value
EssA pfam10661
WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) ...
 25-167 4.92e-57

WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (pfam06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (pfam10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (pfam01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria.


Pssm-ID: 287614  Cd Length: 148  Bit Score: 175.46  E-value: 4.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446518315   25 IRSAADSYLGDDGKIKFKVDRLEESDQEKNKKEHKETELDKASIELFNQDIEEEIEKKKKKEQKDMEALRDSLFIKQKEN 104
Cdd:pfam10661   1 IGSAADSYLEDDGKMDFKVDRLIKDKQEKNEKQLRETELDKAFISLFTTETEEEINEKKKAEKKEMEDIEDSLFSEDKEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446518315  105 N-SVKDTKNSLFSSEYIVRKSADEVASNETMNEEPISIT----IILLFGGGILLICIGIYTVLRKSWR 167
Cdd:pfam10661  81 NvAVKDTKDSLFSSEYEVRASNTETASSETAEEESTSSTssniIIGLFAGGAVALCGGIYVLMRKLWE 148
T7SS_EssA_Firm TIGR03927
type VII secretion protein EssA; Members of this family are associated with type VII secretion ...
 27-167 2.89e-29

type VII secretion protein EssA; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This highly divergent protein family consists largely of a central region of highly polar low-complexity sequence containing occasional LF motifs in weak repeats about 17 residues in length, flanked by hydrophobic N- and C-terminal regions. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 200340 [Multi-domain]  Cd Length: 150  Bit Score: 104.77  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446518315   27 SAADSYLGDDGKIKFKVDRLEESDQEKNKKEHK-ETELDKasiELFNQDIEEEIEKKKKKEQKDMEALRDSLF-IKQKEN 104
Cdd:TIGR03927  12 PSADSAAENDGKLQVKPNRYEKKDIEINTDYLQeETELDK---ELFTPEEQKKITFQKHKEKPEQEELKNQLFsENATEN 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446518315  105 NSVKDTKNSLFSSEYIVRKSADEVASNEtMNEEPISITIILLFGGGILLICIGIYTVLRKSWR 167
Cdd:TIGR03927  89 NTVKATKKQLFSSEYEQTSSSSESTSEE-ETKKTSSILLPVLYAGLILLLAAGIYFLIRKVKD 150
 
Name Accession Description Interval E-value
EssA pfam10661
WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) ...
 25-167 4.92e-57

WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (pfam06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (pfam10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (pfam01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria.


Pssm-ID: 287614  Cd Length: 148  Bit Score: 175.46  E-value: 4.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446518315   25 IRSAADSYLGDDGKIKFKVDRLEESDQEKNKKEHKETELDKASIELFNQDIEEEIEKKKKKEQKDMEALRDSLFIKQKEN 104
Cdd:pfam10661   1 IGSAADSYLEDDGKMDFKVDRLIKDKQEKNEKQLRETELDKAFISLFTTETEEEINEKKKAEKKEMEDIEDSLFSEDKEG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446518315  105 N-SVKDTKNSLFSSEYIVRKSADEVASNETMNEEPISIT----IILLFGGGILLICIGIYTVLRKSWR 167
Cdd:pfam10661  81 NvAVKDTKDSLFSSEYEVRASNTETASSETAEEESTSSTssniIIGLFAGGAVALCGGIYVLMRKLWE 148
T7SS_EssA_Firm TIGR03927
type VII secretion protein EssA; Members of this family are associated with type VII secretion ...
 27-167 2.89e-29

type VII secretion protein EssA; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This highly divergent protein family consists largely of a central region of highly polar low-complexity sequence containing occasional LF motifs in weak repeats about 17 residues in length, flanked by hydrophobic N- and C-terminal regions. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 200340 [Multi-domain]  Cd Length: 150  Bit Score: 104.77  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446518315   27 SAADSYLGDDGKIKFKVDRLEESDQEKNKKEHK-ETELDKasiELFNQDIEEEIEKKKKKEQKDMEALRDSLF-IKQKEN 104
Cdd:TIGR03927  12 PSADSAAENDGKLQVKPNRYEKKDIEINTDYLQeETELDK---ELFTPEEQKKITFQKHKEKPEQEELKNQLFsENATEN 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446518315  105 NSVKDTKNSLFSSEYIVRKSADEVASNEtMNEEPISITIILLFGGGILLICIGIYTVLRKSWR 167
Cdd:TIGR03927  89 NTVKATKKQLFSSEYEQTSSSSESTSEE-ETKKTSSILLPVLYAGLILLLAAGIYFLIRKVKD 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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