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Conserved domains on  [gi|446582373|ref|WP_000659719|]
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MULTISPECIES: mevalonate kinase [Streptococcus]

Protein Classification

mevalonate kinase( domain architecture ID 11446334)

mevalonate kinase catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 10-266 3.12e-80

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 243.98  E-value: 3.12e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  10 AHSKIILMGEHSVVYGYPAIAIPLkNIEVTCLIEEAPQ---LIALDM--------------TDPLSTAIFAALDYLGKTS 72
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAV-DRRATVTVEPSDDdklRIESPDlggtldldpladaaLRYIKAAIEAALEYLGLPL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  73 SKIAYHIESQVPERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTCLSENTIKFIRNIG 152
Cdd:COG1577   80 KGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 153 FSTVPMHLNAYLVIADTGIHGHTKEAVDKVK----SSGEAVLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQ 228
Cdd:COG1577  160 AEPLELPKNLPLVVGDTGVPASTKELVAKVRklkeRNPELYEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRA 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446582373 229 LGVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALV 266
Cdd:COG1577  240 LGVSTPELDRLVEAARKAGALGAKLTGAGGGGCVIALA 277
 
Name Accession Description Interval E-value
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 10-266 3.12e-80

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 243.98  E-value: 3.12e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  10 AHSKIILMGEHSVVYGYPAIAIPLkNIEVTCLIEEAPQ---LIALDM--------------TDPLSTAIFAALDYLGKTS 72
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAV-DRRATVTVEPSDDdklRIESPDlggtldldpladaaLRYIKAAIEAALEYLGLPL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  73 SKIAYHIESQVPERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTCLSENTIKFIRNIG 152
Cdd:COG1577   80 KGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 153 FSTVPMHLNAYLVIADTGIHGHTKEAVDKVK----SSGEAVLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQ 228
Cdd:COG1577  160 AEPLELPKNLPLVVGDTGVPASTKELVAKVRklkeRNPELYEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRA 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446582373 229 LGVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALV 266
Cdd:COG1577  240 LGVSTPELDRLVEAARKAGALGAKLTGAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 10-265 8.35e-78

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 237.57  E-value: 8.35e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373   10 AHSKIILMGEHSVVYGYPAIAIPLKNIEVTCLIEEAP----------QLIAL--DMTDPLSTAIFAALDYLGKTSSK-IA 76
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDgsfiesdlgrGSLDDapDELDGLKYVLAEFLSRFSELNPPpLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373   77 YHIESQVPERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTCLSENTIKFIRNIGFSTV 156
Cdd:TIGR00549  81 ITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATSTSGGPVYFEKGEGEFTK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  157 PMHLNAYLVIADTGIHGHTKEAVDKVK----SSGEAVLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQLGVS 232
Cdd:TIGR00549 161 LISLDGYFVIADTGVSGSTKEAVARVRqlleRFPELIDSIMDAIGELTLEAKAALQDGDVESLGELMNINQGLLKALGVS 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 446582373  233 SLEADHLVEVAISCGALGAKMSGGGLGGCIIAL 265
Cdd:TIGR00549 241 HPKLDQLVEIARKAGALGAKLTGAGGGGCMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 10-273 1.14e-28

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 111.30  E-value: 1.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  10 AHSKIILMGEHSVVYGYPAIAIPLkNIEVTCLIEEAPQLI----ALDMTDPLSTAIFAALDYLGKTSSK--IAYHIESQV 83
Cdd:PRK03926   6 APGKIYLFGEHAVVYGKPAIACAI-DLRTYVRAEFNDDSIyiesDYGKTGEKHPYVSAAIEKMREEADKdgVTVSITSQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  84 PERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTClsenTIKfirniGFSTVPM--HL- 160
Cdd:PRK03926  85 PVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPTDTYVS----TMG-----GFVTIPDrkKLp 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 161 --NAYLVIADTGIHGHTKEAVDKVKSSGEA----VLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQLGVSSL 234
Cdd:PRK03926 156 fpECGIVVGYTGSSGSTKELVANVRKLKEEypelIEPILSSIGKISEKGEELILSGDYVSLGELMNINQGLLDALGVSTK 235

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446582373 235 EADHLVEVAISCGALGAKMSGGGLGGCIIALVKEKREAE 273
Cdd:PRK03926 236 ELSELIYAARTAGALGAKITGAGGGGCMVALAAPEKQSE 274
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 205-284 1.11e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 57.09  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  205 DAIHKSDSKQLGSLMTKAHQSLK---QLGVSSLEADHLVEVAISCGaLGAKMSGGGLGGCIIALVKEKREAERLSQQLER 281
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLEpllVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKDEDDAEEVARALRE 81


                  ...
gi 446582373  282 EGA 284
Cdd:pfam08544  82 AGK 84
 
Name Accession Description Interval E-value
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 10-266 3.12e-80

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 243.98  E-value: 3.12e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  10 AHSKIILMGEHSVVYGYPAIAIPLkNIEVTCLIEEAPQ---LIALDM--------------TDPLSTAIFAALDYLGKTS 72
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAV-DRRATVTVEPSDDdklRIESPDlggtldldpladaaLRYIKAAIEAALEYLGLPL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  73 SKIAYHIESQVPERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTCLSENTIKFIRNIG 152
Cdd:COG1577   80 KGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 153 FSTVPMHLNAYLVIADTGIHGHTKEAVDKVK----SSGEAVLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQ 228
Cdd:COG1577  160 AEPLELPKNLPLVVGDTGVPASTKELVAKVRklkeRNPELYEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRA 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446582373 229 LGVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALV 266
Cdd:COG1577  240 LGVSTPELDRLVEAARKAGALGAKLTGAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 10-265 8.35e-78

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 237.57  E-value: 8.35e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373   10 AHSKIILMGEHSVVYGYPAIAIPLKNIEVTCLIEEAP----------QLIAL--DMTDPLSTAIFAALDYLGKTSSK-IA 76
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDgsfiesdlgrGSLDDapDELDGLKYVLAEFLSRFSELNPPpLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373   77 YHIESQVPERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTCLSENTIKFIRNIGFSTV 156
Cdd:TIGR00549  81 ITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATSTSGGPVYFEKGEGEFTK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  157 PMHLNAYLVIADTGIHGHTKEAVDKVK----SSGEAVLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQLGVS 232
Cdd:TIGR00549 161 LISLDGYFVIADTGVSGSTKEAVARVRqlleRFPELIDSIMDAIGELTLEAKAALQDGDVESLGELMNINQGLLKALGVS 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 446582373  233 SLEADHLVEVAISCGALGAKMSGGGLGGCIIAL 265
Cdd:TIGR00549 241 HPKLDQLVEIARKAGALGAKLTGAGGGGCMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 10-273 1.14e-28

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 111.30  E-value: 1.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  10 AHSKIILMGEHSVVYGYPAIAIPLkNIEVTCLIEEAPQLI----ALDMTDPLSTAIFAALDYLGKTSSK--IAYHIESQV 83
Cdd:PRK03926   6 APGKIYLFGEHAVVYGKPAIACAI-DLRTYVRAEFNDDSIyiesDYGKTGEKHPYVSAAIEKMREEADKdgVTVSITSQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  84 PERRGMGSSAAVAIAAIRAVFDYFDEDLEADLLECLVNRAEMIAHSNPSGLDAKTClsenTIKfirniGFSTVPM--HL- 160
Cdd:PRK03926  85 PVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPTDTYVS----TMG-----GFVTIPDrkKLp 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 161 --NAYLVIADTGIHGHTKEAVDKVKSSGEA----VLPFLKELGYLAEASEDAIHKSDSKQLGSLMTKAHQSLKQLGVSSL 234
Cdd:PRK03926 156 fpECGIVVGYTGSSGSTKELVANVRKLKEEypelIEPILSSIGKISEKGEELILSGDYVSLGELMNINQGLLDALGVSTK 235

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446582373 235 EADHLVEVAISCGALGAKMSGGGLGGCIIALVKEKREAE 273
Cdd:PRK03926 236 ELSELIYAARTAGALGAKITGAGGGGCMVALAAPEKQSE 274
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 13-282 3.75e-18

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 82.98  E-value: 3.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  13 KIILMGEHSVVYGYPAIAIPLKN-----IEVT------CLIEEAPQL--IALDMTDPLSTAIFAALDYLGKTSSK--IAY 77
Cdd:PTZ00298  18 KVILFGEHFVVYGAEAIVAGIDEytecrLELTkgvpglQVVDQRPAVpgYIVEKREEQRKAHQLVLRHLNIDTSVdgLKM 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  78 HIESQVPERRGMGSSAAVAIAAIRAvfdyFDEDLEADLLECLVNRAEMIA----HSNPSGLDAKTCLSENTIKFIRNIG- 152
Cdd:PTZ00298  98 HLGGPLVPSSGIGASASDVVSLSRA----LSELYQLNLTEEEVNLSAFVGeggyHGTPSGADNTAATYGGLISYRRVNGk 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 153 --FSTVPMHLNAYLVIADTGIHGHTKEAVDKVKSSGEAVLPFLKEL--GYLAEASE--DAIHKSDSKQLGSLMTKAHQSL 226
Cdd:PTZ00298 174 svFKRIAFQQPLYLVVCSTGITASTTKVVGDVRKLKENQPTWFNRLleNYNACVSEakEALQKGNLFRVGELMNANHDLC 253

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446582373 227 KQLGVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALVKEKREAERLSQQLERE 282
Cdd:PTZ00298 254 QKLTVSCRELDSIVQTCRTYGALGAKMSGTGRGGLVVALAASEDQRDAIAKAVRAR 309
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
149-268 3.11e-16

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 77.89  E-value: 3.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 149 RNIGFSTVPMHLNAY-LVIADTGI-HGHTKEAVDKVKSSGEAVLPFLkELGYLAEASED-----------------AIH- 208
Cdd:COG0153  188 RSLEYEYVPLPLEGYaLVIVDTNVkHSLADSEYNERRAECEAAAAIL-GVKSLRDVTLEdleaararlgdevlrrrARHv 266

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446582373 209 ---------------KSDSKQLGSLMTKAHQSLKQL-GVSSLEADHLVEVAIS-CGALGAKMSGGGLGGCIIALVKE 268
Cdd:COG0153  267 vtenqrvleavealrAGDLEAFGKLMNASHASLRDDyEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPK 343
PRK03817 PRK03817
galactokinase; Provisional
 194-282 4.57e-13

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 68.48  E-value: 4.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 194 KELGYLAEASE------DAIHKSDSKQLGSLMTKAHQSLKQL-GVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALV 266
Cdd:PRK03817 233 KRAGYVLRENErvlkvrDALKEGDIETLGELLTESHWDLADNyEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALV 312

                         90
                 ....*....|....*.
gi 446582373 267 KEKReAERLSQQLERE 282
Cdd:PRK03817 313 DKGK-FESIGEELLEE 327
PRK00555 PRK00555
galactokinase; Provisional
 205-282 2.15e-12

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 66.42  E-value: 2.15e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446582373 205 DAIHKSDSKQLGSLMTKAHQSLKQ-LGVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALVKEKReAERLSQQLERE 282
Cdd:PRK00555 262 AALADSDFTAAGQLLTASHASMRDdFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADR-AEDVADTVRRA 339
PLN02521 PLN02521
galactokinase
 200-268 1.13e-11

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 64.73  E-value: 1.13e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 200 AEASEDAIHKSDSKQLGSLMTKAHQSLKQL-GVSSLEADHLVEVAISCGALGAKMSGGGLGGCIIALVKE 268
Cdd:PLN02521 380 DTVSSSLSEEEKLKKLGDLMNESHYSCSVLyECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKE 449
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 205-284 1.11e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 57.09  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  205 DAIHKSDSKQLGSLMTKAHQSLK---QLGVSSLEADHLVEVAISCGaLGAKMSGGGLGGCIIALVKEKREAERLSQQLER 281
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLEpllVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKDEDDAEEVARALRE 81


                  ...
gi 446582373  282 EGA 284
Cdd:pfam08544  82 AGK 84
PRK05322 PRK05322
galactokinase; Provisional
 205-268 4.56e-10

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 59.49  E-value: 4.56e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446582373 205 DAIHKSDSKQLGSLMTKAHQSLKQ-LGVSSLEADHLVEVAISC-GALGAKMSGGGLGGCIIALVKE 268
Cdd:PRK05322 286 KALKAGDLEKFGRLMNASHVSLRDdYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGCAIAIVKK 351
PRK05101 PRK05101
galactokinase; Provisional
 205-274 4.27e-08

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 53.77  E-value: 4.27e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446582373 205 DAIHKSDSKQLGSLMTKAHQSLK---QLGVSslEADHLVEVAISC----GalGAKMSGGGLGGCIIALV-KEKREAER 274
Cdd:PRK05101 280 SALAAGDLKRMGELMAESHASMRddfEITVP--QIDTLVEIVKAVigdqG--GVRMTGGGFGGCIVALVpEELVEAVR 353
PLN02677 PLN02677
mevalonate kinase
 9-266 2.70e-06

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 48.29  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373   9 KAHSKIILMGEHSVVYGYPAIAI-----------------------------------PLKNIE--------------VT 39
Cdd:PLN02677   6 RAPGKIILAGEHAVVHGSTAVAAaidlytyvslrfppsaenddtlklqlkdlglefswPLARIKealpdlgtpcpstpTS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  40 CLIEEAPQLIAL--DMTDP---------LSTAIFAALDYLGKTSSKIAyhIESQVPERRGMGSSAAVAIAAIRAVFDYFD 108
Cdd:PLN02677  86 CSEETLKSIAALveEQNIPeakiwlssgVSAFLWLYTSILGFNPATVV--VTSELPLGSGLGSSAAFCVALSAALLAASD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 109 -----------EDLEADLLEcLVNR----AEMIAHSNPSGLDAKTCLSENTIKF----IRNIGfSTVPMHlnayLVIADT 169
Cdd:PLN02677 164 sisvstggngwSSLDETDLE-LVNKwafeGEKIIHGKPSGIDNTVSTYGNMIKFksgeLTRLQ-SNMPLK----MLITNT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 170 GIHGHTKEAV-----------DKVKSSGEAVLPFLKELGYLAE-ASEDAIH-KSDSKQLGSLMTKAHQSLKQLGVS--SL 234
Cdd:PLN02677 238 RVGRNTKALVagvseralrhpDAMKSVFNAVDSISEELATIIQsPAEDELSiTEKEEKLKELMEMNQGLLQCMGVShsSI 317

                        330       340       350
                 ....*....|....*....|....*....|..
gi 446582373 235 EADHLVEVAIScgaLGAKMSGGGLGGCIIALV 266
Cdd:PLN02677 318 ETVLRTTLKYK---LVSKLTGAGGGGCVLTLL 346
PTZ00290 PTZ00290
galactokinase; Provisional
 208-287 1.42e-04

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 42.89  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373 208 HKSDSKQLGSLMTKAHQSLKQL-GVSSLEADHLVE-VAISCGALGAKMSGGGLGGCIIALVK---EKREAERLSQQLE-R 281
Cdd:PTZ00290 358 REERFRKAGEILNAGHQGMRDLmKITTPELDFIHElINEEKGVAGGRMMGGGFGGCIILLLKknaVDRVVAHVREKFKaR 437


                 ....*.
gi 446582373 282 EGAVNT 287
Cdd:PTZ00290 438 FGVEND 443
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 49-281 1.81e-03

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 39.31  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373   49 IALDMTDPLSTAIFA-ALDYLGKTSSKIAYHIESQVPERRGMGSSAAVAIAAIRAVFDYFDEDL-EADLLE-CLV--NRA 123
Cdd:TIGR00191  54 IPTEPTDNLIYQVAKrFLDQLGIRMPPVKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLsKERLLDyASEleGHP 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  124 EMIAHSNPSGLDAKTcLSENTIKFIRnigfstVPMHLNAYLVIADTGIHGHTKEAvdkvkssgEAVLPflKELGY---LA 200
Cdd:TIGR00191 134 DNVAPALLGGFQLAF-VEDDKLEVLK------IPIFSKLDWVLAIPNIEVSTAEA--------RAVLP--KAYPRqdlVF 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446582373  201 EASEDA--IHKSDSKQ--LGSLMTK--AHQSLKQLGVSSLEADHlvEVAISCGALGAKMSGGglGGCIIALVKEKREAER 274
Cdd:TIGR00191 197 NLSHLAglVHAIYQKKpdLGAIMMKdrIHQPYRESLIPNLFKIK--QAALEKGAYGITISGS--GPTILAMADEEFAEQK 272


                  ....*..
gi 446582373  275 LSQQLER 281
Cdd:TIGR00191 273 EQDLLEV 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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