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Conserved domains on  [gi|446722673|ref|WP_000799986|]
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MULTISPECIES: bifunctional molybdenum cofactor biosynthesis protein MoaC/MoaB [Acinetobacter]

Protein Classification

bifunctional molybdenum cofactor biosynthesis protein MoaC/MoaB( domain architecture ID 11480000)

bifunctional molybdenum cofactor biosynthesis protein MoaC/MoaB catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 1-303 3.76e-159

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


:

Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 446.31  E-value: 3.76e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:PRK03604  11 MVDVSGKPGTLRTARASGIIVTSPETIELLRQGDLPKGDVLTTAKIAGIQAAKRTSELIPLCHPLPLSWVDVEFEIEDDR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673  81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHcePEELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVA 160
Cdd:PRK03604  91 IRIEATVKTIGKTGVEMEALTAVSVAALTIYDMLKPV--DKALEIGGIRLLEKTGGKSGHKRRFRPRTSAAVLVLSDSIA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 161 AGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLEL-SKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGL 239
Cdd:PRK03604 169 AGTKEDRSGKLIVEGLEEAGFEVSHYTIIPDEPAEIAAAVAAWiAEGYALIITTGGTGLGPRDVTPEALAPLLERRLPGI 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446722673 240 MEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLPHP 303
Cdd:PRK03604 249 AEALRSWGQGRTPTAMLSRLVAGMIGNSLVVALPGSPGGASDALAVLLPALFHAFAMVKGEGHH 312
 
Name Accession Description Interval E-value
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 1-303 3.76e-159

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 446.31  E-value: 3.76e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:PRK03604  11 MVDVSGKPGTLRTARASGIIVTSPETIELLRQGDLPKGDVLTTAKIAGIQAAKRTSELIPLCHPLPLSWVDVEFEIEDDR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673  81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHcePEELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVA 160
Cdd:PRK03604  91 IRIEATVKTIGKTGVEMEALTAVSVAALTIYDMLKPV--DKALEIGGIRLLEKTGGKSGHKRRFRPRTSAAVLVLSDSIA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 161 AGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLEL-SKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGL 239
Cdd:PRK03604 169 AGTKEDRSGKLIVEGLEEAGFEVSHYTIIPDEPAEIAAAVAAWiAEGYALIITTGGTGLGPRDVTPEALAPLLERRLPGI 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446722673 240 MEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLPHP 303
Cdd:PRK03604 249 AEALRSWGQGRTPTAMLSRLVAGMIGNSLVVALPGSPGGASDALAVLLPALFHAFAMVKGEGHH 312
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 145-303 4.85e-58

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 183.78  E-value: 4.85e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 145 RQPVSAAVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYAC--IMTVGGTGIGKRD 222
Cdd:COG0521    7 FVPLRIAVLTVSDRRSRGEREDTSGPALVELLEEAGHEVVARRIVPDDKDAIRAALRELIDDEGVdlVLTTGGTGLSPRD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 223 ITVDTLEPLLERKLDGLMEAARSFG-QKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLP 301
Cdd:COG0521   87 VTPEATRPLLDKELPGFGELFRALSlEEIGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEAILPELPHAVDLLNGVD 166


                 ..
gi 446722673 302 HP 303
Cdd:COG0521  167 HE 168
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
 1-116 1.82e-56

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 178.69  E-value: 1.82e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673    1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYEL--EH 78
Cdd:pfam01967   1 MVDVSDKPVTLRTAVAEGRIRLSPETLELIREGTVKKGDVLAVARIAGIMAAKKTSDLIPLCHPLPLTGVDVEFELdeEE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 446722673   79 DFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKP 116
Cdd:pfam01967  81 DGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKA 118
MogA_MoaB cd00886
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ...
 148-295 2.42e-55

MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.


Pssm-ID: 238451 [Multi-domain]  Cd Length: 152  Bit Score: 176.51  E-value: 2.42e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 148 VSAAVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKS--YACIMTVGGTGIGKRDITV 225
Cdd:cd00886    1 LRAAVLTVSDTRSAGEAEDRSGPALVELLEEAGHEVVAYEIVPDDKDEIREALIEWADEdgVDLILTTGGTGLAPRDVTP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 226 DTLEPLLERKLDGLMEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFD 295
Cdd:cd00886   81 EATRPLLDKELPGFGEAFRALSLEETGTAMLSRAVAGIRGGTLIFNLPGSPKAVREALEVILPELPHLLD 150
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
 1-115 2.14e-40

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 137.95  E-value: 2.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673    1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:TIGR00581  12 MVDISAKAETVREAVASGFVRMKPETVAMISEGRVPKGDVLATARVAGIMAAKRTGDLIPLCHPLPLSKVEVELTVREDR 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 446722673   81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:TIGR00581  92 VEITATVRTTGRTGVEMEALTAVSVAALTVYDMCK 126
MoCF_biosynth smart00852
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 151-286 4.16e-26

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.


Pssm-ID: 214856 [Multi-domain]  Cd Length: 138  Bit Score: 100.36  E-value: 4.16e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   151 AVIVLSDTVAAGRK-PDTAGKSVVETLTEAGFDPIHYQIL--PDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDT 227
Cdd:smart00852   1 AIISTGDELLSGGQiRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPDDLTPEA 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 446722673   228 LEPLLERKLDGLMEAARSfGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAI 286
Cdd:smart00852  81 LAELGGRELLGHGVAMRP-GGPPGPLANLSGTAPGVRGKKPVFGLPGNPVAALVMFEEL 138
 
Name Accession Description Interval E-value
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 1-303 3.76e-159

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 446.31  E-value: 3.76e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:PRK03604  11 MVDVSGKPGTLRTARASGIIVTSPETIELLRQGDLPKGDVLTTAKIAGIQAAKRTSELIPLCHPLPLSWVDVEFEIEDDR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673  81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKPHcePEELWMDQCKLLKKKGGKSHFKRVLRQPVSAAVIVLSDTVA 160
Cdd:PRK03604  91 IRIEATVKTIGKTGVEMEALTAVSVAALTIYDMLKPV--DKALEIGGIRLLEKTGGKSGHKRRFRPRTSAAVLVLSDSIA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 161 AGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLEL-SKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGL 239
Cdd:PRK03604 169 AGTKEDRSGKLIVEGLEEAGFEVSHYTIIPDEPAEIAAAVAAWiAEGYALIITTGGTGLGPRDVTPEALAPLLERRLPGI 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446722673 240 MEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLPHP 303
Cdd:PRK03604 249 AEALRSWGQGRTPTAMLSRLVAGMIGNSLVVALPGSPGGASDALAVLLPALFHAFAMVKGEGHH 312
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 145-303 4.85e-58

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 183.78  E-value: 4.85e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 145 RQPVSAAVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYAC--IMTVGGTGIGKRD 222
Cdd:COG0521    7 FVPLRIAVLTVSDRRSRGEREDTSGPALVELLEEAGHEVVARRIVPDDKDAIRAALRELIDDEGVdlVLTTGGTGLSPRD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 223 ITVDTLEPLLERKLDGLMEAARSFG-QKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFDVCRDLP 301
Cdd:COG0521   87 VTPEATRPLLDKELPGFGELFRALSlEEIGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEAILPELPHAVDLLNGVD 166


                 ..
gi 446722673 302 HP 303
Cdd:COG0521  167 HE 168
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
 1-116 1.82e-56

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 178.69  E-value: 1.82e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673    1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYEL--EH 78
Cdd:pfam01967   1 MVDVSDKPVTLRTAVAEGRIRLSPETLELIREGTVKKGDVLAVARIAGIMAAKKTSDLIPLCHPLPLTGVDVEFELdeEE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 446722673   79 DFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLKP 116
Cdd:pfam01967  81 DGVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCKA 118
MogA_MoaB cd00886
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ...
 148-295 2.42e-55

MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.


Pssm-ID: 238451 [Multi-domain]  Cd Length: 152  Bit Score: 176.51  E-value: 2.42e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 148 VSAAVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKS--YACIMTVGGTGIGKRDITV 225
Cdd:cd00886    1 LRAAVLTVSDTRSAGEAEDRSGPALVELLEEAGHEVVAYEIVPDDKDEIREALIEWADEdgVDLILTTGGTGLAPRDVTP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 226 DTLEPLLERKLDGLMEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVHIFD 295
Cdd:cd00886   81 EATRPLLDKELPGFGEAFRALSLEETGTAMLSRAVAGIRGGTLIFNLPGSPKAVREALEVILPELPHLLD 150
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
 1-115 4.05e-54

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 173.32  E-value: 4.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:COG0315   15 MVDVSDKAVTARTAVAEGRVRMSPETLALIREGGVKKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDDDL 94

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446722673  81 --VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:COG0315   95 sgVEITATVKTTGKTGVEMEALTAVSVAALTIYDMCK 131
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
1-115 2.28e-49

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 161.51  E-value: 2.28e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYEL--EH 78
Cdd:PRK09364  15 MVDVSDKAETVRTAVAEGSVRMSPETLALIRDGTAKKGDVLATARIAGIMAAKRTSDLIPLCHPLMLTGVDVDFEWdpEL 94

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446722673  79 DFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:PRK09364  95 PGVRITATVKTTGKTGVEMEALTAVSVAALTIYDMCK 131
MoaC cd00528
MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, ...
 1-115 1.35e-46

MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238293  Cd Length: 136  Bit Score: 153.44  E-value: 1.35e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:cd00528    1 MVDVSDKAVTERTAVAEGRVRLSPETLDLIREGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELDEDT 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446722673  81 --VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:cd00528   81 sgVRIRATVRTTGKTGVEMEALTAVSVAALTIYDMCK 117
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
 1-115 2.28e-46

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 153.09  E-value: 2.28e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYEL--EH 78
Cdd:cd01420    1 MVDVSDKAVTERTAVAEGRVRMSPETLDLITEGQLPKGDVLAVARIAGIMAAKRTSELIPLCHPLPLTGVDVDFELdeET 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446722673  79 DFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:cd01420   81 SGVRIEATVRTTGRTGVEMEALTAVSVAALTIYDMCK 117
PRK12343 PRK12343
cyclic pyranopterin monophosphate synthase MoaC;
1-115 2.39e-41

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 237067  Cd Length: 151  Bit Score: 140.43  E-value: 2.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:PRK12343   9 MVDVSEKEDVLRIAVAEGFIKLKPETIEAIREGEVEKGNVLATARVAGILAVKKTPELIPMCHPIPITGVDVDFEVGEDG 88

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446722673  81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:PRK12343  89 IEARVTVKTTYKTGVEMEALTGVSVALLTIWDMVK 123
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
 1-115 2.14e-40

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 137.95  E-value: 2.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673    1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:TIGR00581  12 MVDISAKAETVREAVASGFVRMKPETVAMISEGRVPKGDVLATARVAGIMAAKRTGDLIPLCHPLPLSKVEVELTVREDR 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 446722673   81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:TIGR00581  92 VEITATVRTTGRTGVEMEALTAVSVAALTVYDMCK 126
MoaC_A cd01419
MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) ...
 1-115 2.64e-39

MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238707  Cd Length: 141  Bit Score: 134.80  E-value: 2.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHDF 80
Cdd:cd01419    1 MVDISSKEDVAREAVASGFIKLKEETIKAIREGKVEKGNVIATARIAGILAVKKTPELIPMCHPIPITGVDVDFEVEEDG 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446722673  81 VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:cd01419   81 IEVRCTVKTTYKTGVEMEALTGVSVALLTIWDMVK 115
PRK14499 PRK14499
cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;
1-115 1.69e-31

cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;


Pssm-ID: 237733 [Multi-domain]  Cd Length: 308  Bit Score: 119.58  E-value: 1.69e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELEHD- 79
Cdd:PRK14499  14 MVDVSSKEPTFRVAVASGRIYVGKEVIEAIEERLLPKGDVFSVAKIAAIMAAKKTSELIPLCHNIFLSGVDVSYEINREe 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446722673  80 -FVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:PRK14499  94 gYIEAVSEVKTEAKTGAEMEAITAVSIFLETIYDMCK 130
MoCF_biosynth pfam00994
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 151-292 7.74e-29

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.


Pssm-ID: 425979 [Multi-domain]  Cd Length: 143  Bit Score: 107.72  E-value: 7.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673  151 AVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEP 230
Cdd:pfam00994   1 AIITTGDELLPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDVTPEALAE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446722673  231 LLERKLDGLMEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAIL-PALVH 292
Cdd:pfam00994  81 LGGRELPGFEELFRGVSLKPGKPVGTAPGAILSRAGKTVFGLPGSPVAAKVMFELLLlPLLRH 143
MoCF_biosynth smart00852
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 151-286 4.16e-26

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.


Pssm-ID: 214856 [Multi-domain]  Cd Length: 138  Bit Score: 100.36  E-value: 4.16e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   151 AVIVLSDTVAAGRK-PDTAGKSVVETLTEAGFDPIHYQIL--PDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDT 227
Cdd:smart00852   1 AIISTGDELLSGGQiRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPDDLTPEA 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 446722673   228 LEPLLERKLDGLMEAARSfGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAI 286
Cdd:smart00852  81 LAELGGRELLGHGVAMRP-GGPPGPLANLSGTAPGVRGKKPVFGLPGNPVAALVMFEEL 138
MoCF_BD cd00758
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ...
 150-290 1.02e-25

MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.


Pssm-ID: 238387 [Multi-domain]  Cd Length: 133  Bit Score: 99.34  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 150 AAVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLE 229
Cdd:cd00758    2 VAIVTVSDELSQGQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRRDVTPEALA 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446722673 230 PLLERKLDGlmeaarsfgqKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAA-ILPAL 290
Cdd:cd00758   82 ELGEREAHG----------KGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEAlVLPAL 133
molyb_syn TIGR00177
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ...
 148-287 6.94e-24

molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.


Pssm-ID: 272944 [Multi-domain]  Cd Length: 148  Bit Score: 94.69  E-value: 6.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673  148 VSAAVIVLSDTVAAGRKP-------DTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGK 220
Cdd:TIGR00177   1 PRVAVISVGDELVEGGQPlepgqiyDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446722673  221 RDITVDTLEPLLERKLDGLMEAarsfgQKRTPYAAMSRG----VAGFIDRSLVVTLPGSRGGASESMAAIL 287
Cdd:TIGR00177  81 RDVTPEALEELGEKEIPGFGEF-----RMLSSLPVLSRPgkpaTAGVRGGTLIFNLPGNPVSALVTFEVLI 146
PRK14500 PRK14500
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; ...
 1-117 4.18e-22

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional


Pssm-ID: 237734 [Multi-domain]  Cd Length: 346  Bit Score: 94.58  E-value: 4.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNT--EKGDALKTARVAGILAAKRTDELIPLCHPLPI----YRADVEY 74
Cdd:PRK14500  13 MVDISQKVVSDRRAVAQAIVQLPPAIKDYVTGQDIflKKGPVIQTAIIAGTMAVKRTADLIPFCHTLPIhgckFDINIVY 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446722673  75 ELEHDFVKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK---PH 117
Cdd:PRK14500  93 QKRDLEIFLQCAVKTNYKTGVEMEALCGVAVAALTIYDMCKsisPH 138
PLN02699 PLN02699
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
 148-292 1.85e-20

Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase


Pssm-ID: 215376 [Multi-domain]  Cd Length: 659  Bit Score: 91.41  E-value: 1.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 148 VSAAVIVLSDTVAAGRKPDTAGK---SVVETLTE--AGFDPIHYQILPDEADTLKNLVLELS--KSYACIMTVGGTGIGK 220
Cdd:PLN02699 459 VKVAILTVSDTVSSGAGPDRSGPravSVVNSSSEklGGAKVVATAVVPDDVEKIKDVLQKWSdiDRMDLILTLGGTGFTP 538

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446722673 221 RDITVDTLEPLLERKLDGLMEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPGSRGGASESMAAILPALVH 292
Cdd:PLN02699 539 RDVTPEATKEVIQKETPGLLYVMMQESLKVTPFAMLSRSAAGIRGSTLIINMPGNPNAVAECMEALLPALKH 610
mogA PRK09417
molybdenum cofactor biosynthesis protein MogA; Provisional
 151-274 1.56e-17

molybdenum cofactor biosynthesis protein MogA; Provisional


Pssm-ID: 181837 [Multi-domain]  Cd Length: 193  Bit Score: 78.84  E-value: 1.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 151 AVIVLSDTVAAGRKPDTAGKSVVETLTEAGFDP--IHYQILPDEADTLKNLVLELSKSYAC--IMTVGGTGIGKRDITVD 226
Cdd:PRK09417   7 GLVSISDRASSGVYEDKGIPALEEWLASALTSPfeIETRLIPDEQDLIEQTLIELVDEMGCdlVLTTGGTGPARRDVTPE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446722673 227 TLEPLLERKLDGLMEAARSFGQKRTPYAAMSRGVAGFIDRSLVVTLPG 274
Cdd:PRK09417  87 ATLAVADKEMPGFGEQMRQISLKFVPTAILSRQVAVIRGQSLIINLPG 134
PLN02375 PLN02375
molybderin biosynthesis protein CNX3
 1-115 5.34e-17

molybderin biosynthesis protein CNX3


Pssm-ID: 178003 [Multi-domain]  Cd Length: 270  Bit Score: 79.03  E-value: 5.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673   1 MKNVGMKPESYRVAEAQAILYAPPHCIELLRQGNTEKGDALKTARVAGILAAKRTDELIPLCHPLPIYRADVEYELE-HD 79
Cdd:PLN02375 127 MVDVSSKDNSKRTALACCKVILGKRVFDLVLANQMGKGDVLGVAKIAGINGAKQTSSLIPLCHNIALTHVRVDLRLNpED 206

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446722673  80 F-VKIITVVETIGPTGVEMEALTAASLAGLTIYDMLK 115
Cdd:PLN02375 207 FsVDIEGEASCTGKTGVEMEAMTAVSVAGLTVYDMCK 243
MoeA COG0303
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ...
 176-274 1.75e-06

Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440072 [Multi-domain]  Cd Length: 401  Bit Score: 48.93  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 176 LTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPL-LERKLDGLmeaarsfgqkrtpya 254
Cdd:COG0303  208 LREAGAEVVDLGIVPDDPEALRAALREALAEADLVITSGGVSVGDYDLVKEALEELgAEVLFHKV--------------- 272

                         90       100
                 ....*....|....*....|...
gi 446722673 255 AMSRG---VAGFIDRSLVVTLPG 274
Cdd:COG0303  273 AMKPGkplAFGRLGGKPVFGLPG 295
MoeA cd00887
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 142-231 2.78e-06

MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.


Pssm-ID: 238452 [Multi-domain]  Cd Length: 394  Bit Score: 48.26  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 142 RVLRQPVsaaVIVLS---------DTVAAGRKPDTAGKSVVETLTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMT 212
Cdd:cd00887  164 PVYRRPR---VAIIStgdelvepgEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVIT 240

                         90
                 ....*....|....*....
gi 446722673 213 VGGTGIGKRDITVDTLEPL 231
Cdd:cd00887  241 SGGVSVGDYDFVKEVLEEL 259
PRK14498 PRK14498
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ...
 176-274 5.08e-04

putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional


Pssm-ID: 237732 [Multi-domain]  Cd Length: 633  Bit Score: 41.35  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446722673 176 LTEAGFDPIHYQILPDEADTLKNLVLELSKSYACIMTVGGTGIGKRDITVDTLEPLLERKLDGLmeaarsfgqkrtpyaA 255
Cdd:PRK14498 222 VEEAGGEPVRYGIVPDDEEELEAALRKALKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHGV---------------A 286

                         90       100
                 ....*....|....*....|..
gi 446722673 256 MSRG---VAGFIDRSLVVTLPG 274
Cdd:PRK14498 287 IKPGkptILGVIGGKPVVGLPG 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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