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Conserved domains on  [gi|446920439|ref|WP_000997695|]
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MULTISPECIES: IS256-like element ISEf1 family transposase [Bacteria]

Protein Classification

transposase( domain architecture ID 11465190)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism; may belong to the IS256 family

Gene Ontology:  GO:0004803|GO:0003677|GO:0006313
PubMed:  17981967|20543074

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
2-377 2.46e-169

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


:

Pssm-ID: 442557  Cd Length: 400  Bit Score: 478.92  E-value: 2.46e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   2 NDFTTEIVQTLVTKGD-----LNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGFNSGNSRNGSYFRSIKTEYGELTLE 76
Cdd:COG3328    1 KTLTKELLEELLSELLegddlFDDLLRELLKELLEQALEAELDAHLGAEKYERTGGERGNSRNGYRERTVKTRVGELELR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  77 IPRDRNGEFKQQTLPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYGHHYTPQTMSNMTKVLTEEVNAFKSRALNDK 156
Cdd:COG3328   81 VPRDRDGSFEPQLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 157 YVAIFMDATYIPLKR-QTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKD 235
Cdd:COG3328  161 YPYVYLDAIYLKVREdGRVVNKAVYVALGVNEDGRKEVLGLWVGESESAAFWLEVLRDLKNRGLKDVLLVVSDGLKGLPE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 236 TIHQIYPKAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIEN-QDLL 314
Cdd:COG3328  241 AIEAVFPGARWQRCIVHKIRNSLKYVPKKDRKAVAADLKAIYQAPTKEAAEAALDAFAEKWGKKYPKAAKSLEENwDELL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446920439 315 TFYDFPPSIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIFDTYNQKFLNRSHK 377
Cdd:COG3328  321 TFFDFPAEIRRHIYTTNPIERLNREIRRRTKVVGIFPNEEAALKLVYLALQEASKKWTMGIRR 383
 
Name Accession Description Interval E-value
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
2-377 2.46e-169

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


Pssm-ID: 442557  Cd Length: 400  Bit Score: 478.92  E-value: 2.46e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   2 NDFTTEIVQTLVTKGD-----LNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGFNSGNSRNGSYFRSIKTEYGELTLE 76
Cdd:COG3328    1 KTLTKELLEELLSELLegddlFDDLLRELLKELLEQALEAELDAHLGAEKYERTGGERGNSRNGYRERTVKTRVGELELR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  77 IPRDRNGEFKQQTLPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYGHHYTPQTMSNMTKVLTEEVNAFKSRALNDK 156
Cdd:COG3328   81 VPRDRDGSFEPQLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 157 YVAIFMDATYIPLKR-QTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKD 235
Cdd:COG3328  161 YPYVYLDAIYLKVREdGRVVNKAVYVALGVNEDGRKEVLGLWVGESESAAFWLEVLRDLKNRGLKDVLLVVSDGLKGLPE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 236 TIHQIYPKAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIEN-QDLL 314
Cdd:COG3328  241 AIEAVFPGARWQRCIVHKIRNSLKYVPKKDRKAVAADLKAIYQAPTKEAAEAALDAFAEKWGKKYPKAAKSLEENwDELL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446920439 315 TFYDFPPSIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIFDTYNQKFLNRSHK 377
Cdd:COG3328  321 TFFDFPAEIRRHIYTTNPIERLNREIRRRTKVVGIFPNEEAALKLVYLALQEASKKWTMGIRR 383
transpos_IS256 NF033543
IS256 family transposase; Members of this family belong to the branch of the IS256-like family ...
1-390 9.36e-164

IS256 family transposase; Members of this family belong to the branch of the IS256-like family of transposases that includes the founding member. It excludes the IS1249 group.


Pssm-ID: 468074 [Multi-domain]  Cd Length: 406  Bit Score: 465.16  E-value: 9.36e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   1 MNDFTTEIVQTLVTKGDlNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGfnSGNSRNGSYFRSIKTEYGELTLEIPRD 80
Cdd:NF033543   9 LLDEALLGLKALEDLTD-DELLRELLKALLEQLLEAELTAHLGAEKYERTG--RGNVRNGYYPRTVLTRGGPVELRVPRD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  81 RNGEFKQQT-LPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYGHHYTPQTMSNMTKVLTEEVNAFKSRALNDKYVA 159
Cdd:NF033543  86 RDGSFEPQLiLKRYRRSEKALEAVIIELYLKGVSTRDIQEALEELYGIDVSSKSVSRLTDAVDEEVEAWQNRPLEERYPY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 160 IFMDATYIPLK-RQTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKDTIH 238
Cdd:NF033543 166 VFLDATYLKVRdGGRVVNKAVLVALGVDADGKKEVLGLWIGPSESAAFWLEVLRDLKNRGLKGVLLVVSDGLKGLPEAIR 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 239 QIYPKAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIENQD-LLTFY 317
Cdd:NF033543 246 EVFPGATWQRCIVHKIRNVLAKVPKKDRKEVAAALKAIYQAPDAEEAEAALDAFAEELWKKYPKAAASLEEAWEdLLAFF 325
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446920439 318 DFPPSIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIFDTYNQKFLNRshKGFQQVTDTLVSMF 390
Cdd:NF033543 326 DFPPEHRRSIYTTNAIESLNAEIRRRTKVVGIFPNDESALRLLYALLLEAEKKWRRR--RGYKQLLSLLAILK 396
Transposase_mut pfam00872
Transposase, Mutator family;
6-364 1.47e-113

Transposase, Mutator family;


Pssm-ID: 307151  Cd Length: 380  Bit Score: 336.28  E-value: 1.47e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439    6 TEIVQTLVTKGDLNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGFNSgNSRNGSYFRSIKTEYGELTLEIPRDRNGEF 85
Cdd:pfam00872  10 SEALQAIIELQGKDDLLRTLLKTVMNALLEAELTEHLGAARYERTEERS-NQRNGSYSRTFITRAGTLELRIPRDRNGSF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   86 KQQTLPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYG-HHYTPQTMSNMTKVLTEEVNAFKSRALNDK-YVAIFMD 163
Cdd:pfam00872  89 SPALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYGhKSVSKSTVSRITKRLDEAVGAFRNRPLEENeYPYLFLD 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  164 ATYIPLKRQTVSK-EAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKDTIHQIYP 242
Cdd:pfam00872 169 ATYLKVREEGRVVsKAVYIAIGIDADGRREILGFEVGDGESEAFWLTFLTSLKNRGLQGVELVVSDAHKGLVAAISAVFP 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  243 KAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIEN-QDLLTFYDFPP 321
Cdd:pfam00872 249 GAAWQRCRVHFLRNLLAKVPKKDRDDVLEALKTIYRAPDAEEARAALEAFLEKYGKKYPAIAESLDNAwEDLLAFTAFPE 328
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 446920439  322 SIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIF 364
Cdd:pfam00872 329 QIWRRIWSTNPIERLNKEIRRRTRVVGIFPNEESALRLLGAVL 371
 
Name Accession Description Interval E-value
IS285 COG3328
Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];
2-377 2.46e-169

Transposase (or an inactivated derivative) [Mobilome: prophages, transposons];


Pssm-ID: 442557  Cd Length: 400  Bit Score: 478.92  E-value: 2.46e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   2 NDFTTEIVQTLVTKGD-----LNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGFNSGNSRNGSYFRSIKTEYGELTLE 76
Cdd:COG3328    1 KTLTKELLEELLSELLegddlFDDLLRELLKELLEQALEAELDAHLGAEKYERTGGERGNSRNGYRERTVKTRVGELELR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  77 IPRDRNGEFKQQTLPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYGHHYTPQTMSNMTKVLTEEVNAFKSRALNDK 156
Cdd:COG3328   81 VPRDRDGSFEPQLLPKYQRREQALEEVIIELYAKGVSTRDIEEALEELYGTGLSKSTVSRITDKLDEEVEAWQNRPLEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 157 YVAIFMDATYIPLKR-QTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKD 235
Cdd:COG3328  161 YPYVYLDAIYLKVREdGRVVNKAVYVALGVNEDGRKEVLGLWVGESESAAFWLEVLRDLKNRGLKDVLLVVSDGLKGLPE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 236 TIHQIYPKAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIEN-QDLL 314
Cdd:COG3328  241 AIEAVFPGARWQRCIVHKIRNSLKYVPKKDRKAVAADLKAIYQAPTKEAAEAALDAFAEKWGKKYPKAAKSLEENwDELL 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446920439 315 TFYDFPPSIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIFDTYNQKFLNRSHK 377
Cdd:COG3328  321 TFFDFPAEIRRHIYTTNPIERLNREIRRRTKVVGIFPNEEAALKLVYLALQEASKKWTMGIRR 383
transpos_IS256 NF033543
IS256 family transposase; Members of this family belong to the branch of the IS256-like family ...
1-390 9.36e-164

IS256 family transposase; Members of this family belong to the branch of the IS256-like family of transposases that includes the founding member. It excludes the IS1249 group.


Pssm-ID: 468074 [Multi-domain]  Cd Length: 406  Bit Score: 465.16  E-value: 9.36e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   1 MNDFTTEIVQTLVTKGDlNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGfnSGNSRNGSYFRSIKTEYGELTLEIPRD 80
Cdd:NF033543   9 LLDEALLGLKALEDLTD-DELLRELLKALLEQLLEAELTAHLGAEKYERTG--RGNVRNGYYPRTVLTRGGPVELRVPRD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  81 RNGEFKQQT-LPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYGHHYTPQTMSNMTKVLTEEVNAFKSRALNDKYVA 159
Cdd:NF033543  86 RDGSFEPQLiLKRYRRSEKALEAVIIELYLKGVSTRDIQEALEELYGIDVSSKSVSRLTDAVDEEVEAWQNRPLEERYPY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 160 IFMDATYIPLK-RQTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKDTIH 238
Cdd:NF033543 166 VFLDATYLKVRdGGRVVNKAVLVALGVDADGKKEVLGLWIGPSESAAFWLEVLRDLKNRGLKGVLLVVSDGLKGLPEAIR 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439 239 QIYPKAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIENQD-LLTFY 317
Cdd:NF033543 246 EVFPGATWQRCIVHKIRNVLAKVPKKDRKEVAAALKAIYQAPDAEEAEAALDAFAEELWKKYPKAAASLEEAWEdLLAFF 325
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446920439 318 DFPPSIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIFDTYNQKFLNRshKGFQQVTDTLVSMF 390
Cdd:NF033543 326 DFPPEHRRSIYTTNAIESLNAEIRRRTKVVGIFPNDESALRLLYALLLEAEKKWRRR--RGYKQLLSLLAILK 396
Transposase_mut pfam00872
Transposase, Mutator family;
6-364 1.47e-113

Transposase, Mutator family;


Pssm-ID: 307151  Cd Length: 380  Bit Score: 336.28  E-value: 1.47e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439    6 TEIVQTLVTKGDLNELFRSHLEKAINTLLRTELTAFLDYEKYDRTGFNSgNSRNGSYFRSIKTEYGELTLEIPRDRNGEF 85
Cdd:pfam00872  10 SEALQAIIELQGKDDLLRTLLKTVMNALLEAELTEHLGAARYERTEERS-NQRNGSYSRTFITRAGTLELRIPRDRNGSF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439   86 KQQTLPAYKRTNDTLETTIIHLFEKGVTMSEIADLIEKMYG-HHYTPQTMSNMTKVLTEEVNAFKSRALNDK-YVAIFMD 163
Cdd:pfam00872  89 SPALLERYQRRERALDAVVIEMYVSGVSTRKVSDIVEELYGhKSVSKSTVSRITKRLDEAVGAFRNRPLEENeYPYLFLD 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  164 ATYIPLKRQTVSK-EAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEVLLFITDGLKGMKDTIHQIYP 242
Cdd:pfam00872 169 ATYLKVREEGRVVsKAVYIAIGIDADGRREILGFEVGDGESEAFWLTFLTSLKNRGLQGVELVVSDAHKGLVAAISAVFP 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  243 KAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANSKEEANTFLSGMIEKWKKNYPKVTQSLIEN-QDLLTFYDFPP 321
Cdd:pfam00872 249 GAAWQRCRVHFLRNLLAKVPKKDRDDVLEALKTIYRAPDAEEARAALEAFLEKYGKKYPAIAESLDNAwEDLLAFTAFPE 328
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 446920439  322 SIRRTIYSTNLIESFNKQIKRYSRRKEQFQNEESLERFLVSIF 364
Cdd:pfam00872 329 QIWRRIWSTNPIERLNKEIRRRTRVVGIFPNEESALRLLGAVL 371
MULE pfam10551
MULE transposase domain; This domain was identified by Babu and colleagues.
160-256 1.46e-06

MULE transposase domain; This domain was identified by Babu and colleagues.


Pssm-ID: 463145 [Multi-domain]  Cd Length: 98  Bit Score: 46.10  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446920439  160 IFMDATYiplkRQTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINS----RGVQEVLLFITDGLKGMKD 235
Cdd:pfam10551   2 LLIDGTY----KTNKYKMPLFTAVGVDHHGQSFPIAFGLVSNETEESFTWLFDQLIAfrecMSGLSPQVIITDRDKALKN 77
                          90       100
                  ....*....|....*....|.
gi 446920439  236 TIHQIYPKAKYQHCCIHVSRN 256
Cdd:pfam10551  78 AINLVFPEAQHRLCIFHINKN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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