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Conserved domains on  [gi|446926643|ref|WP_001003899|]
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MULTISPECIES: hypothetical protein [Bacillus]

Protein Classification

LSm family protein( domain architecture ID 249)

LSm family protein such as eukaryotic LSm (Sm-like proteins) and bacterial LSm-related Hfq proteins, that have an Sm fold consisting of a five-stranded beta-sheet and an alpha-helix at the N-terminus, and are involved in processes associated with RNA processing and gene expression regulation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sm_like super family cl00259
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
6-36 2.13e-03

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


The actual alignment was detected with superfamily member cd01734:

Pssm-ID: 469694  Cd Length: 72  Bit Score: 35.50  E-value: 2.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446926643   6 KSIGENIYVKLI----GEKRFKGVLIDVGNDIVVL 36
Cdd:cd01734   14 RFIGKEVKVKLKepidGRKKFTGELLGVDDDTVTL 48
 
Name Accession Description Interval E-value
YlxS_C cd01734
Bacillus subtilis YxlS-like, C-terminal domain; YxlS is a Bacillus subtilis gene of unknown ...
6-36 2.13e-03

Bacillus subtilis YxlS-like, C-terminal domain; YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix and a five-stranded beta-sheet. This CD represents the C-terminal domain which has a fold similar to the Sm fold of proteins like Sm-D3.


Pssm-ID: 212481  Cd Length: 72  Bit Score: 35.50  E-value: 2.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446926643   6 KSIGENIYVKLI----GEKRFKGVLIDVGNDIVVL 36
Cdd:cd01734   14 RFIGKEVKVKLKepidGRKKFTGELLGVDDDTVTL 48
 
Name Accession Description Interval E-value
YlxS_C cd01734
Bacillus subtilis YxlS-like, C-terminal domain; YxlS is a Bacillus subtilis gene of unknown ...
6-36 2.13e-03

Bacillus subtilis YxlS-like, C-terminal domain; YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix and a five-stranded beta-sheet. This CD represents the C-terminal domain which has a fold similar to the Sm fold of proteins like Sm-D3.


Pssm-ID: 212481  Cd Length: 72  Bit Score: 35.50  E-value: 2.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446926643   6 KSIGENIYVKLI----GEKRFKGVLIDVGNDIVVL 36
Cdd:cd01734   14 RFIGKEVKVKLKepidGRKKFTGELLGVDDDTVTL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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