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Conserved domains on  [gi|446945352|ref|WP_001022608|]
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MULTISPECIES: maltosaccharide ABC transporter permease MalD [Bacillus]

Protein Classification

sugar ABC transporter permease( domain architecture ID 10790449)

sugar ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of sugar substrates including oligosaccharides and maltodextrin

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020|GO:0008643
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 1-280 1.41e-147

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


:

Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 414.55  E-value: 1.41e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   1 MNIKRQKMLRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDSLSGSSIIPQNATLDHYRKLLdlENSNYLLWYKNTLKVS 80
Cdd:COG3833    5 KSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLF--TETPFLRWFLNSLIVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  81 VLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLM 160
Cdd:COG3833   83 VVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 161 KGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAKKF 240
Cdd:COG3833  163 KGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446945352 241 GNEFTTFAAGSVLIAIPISILFLSLQKYFISGLTAGGTKG 280
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
 
Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 1-280 1.41e-147

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 414.55  E-value: 1.41e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   1 MNIKRQKMLRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDSLSGSSIIPQNATLDHYRKLLdlENSNYLLWYKNTLKVS 80
Cdd:COG3833    5 KSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLF--TETPFLRWFLNSLIVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  81 VLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLM 160
Cdd:COG3833   83 VVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 161 KGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAKKF 240
Cdd:COG3833  163 KGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446945352 241 GNEFTTFAAGSVLIAIPISILFLSLQKYFISGLTAGGTKG 280
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
9-280 2.05e-63

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 201.09  E-value: 2.05e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   9 LRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDsLSGSSIIPQNATLDHYRKLLDLENSN-----------YLLWYKNTL 77
Cdd:PRK10998  11 LRLFATHLLLLGFIALIMFPLLMVIAISLREGN-FATGSLIPEQISWEHWKLALGFSVEHadgrvtpppfpVLLWLWNSV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  78 KVSVLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGL------IDTHLALILIYVGG 151
Cdd:PRK10998  90 KVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQyipfigLNTHGGVIFAYLGG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 152 aIPMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVG 231
Cdd:PRK10998 170 -IALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVG 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446945352 232 lyemvAKKFGNE----FTTFAAGSVLIAIPISILFLSLQKYFISGLTAGGTKG 280
Cdd:PRK10998 249 -----MQQYLNPqnylWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-258 1.43e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 75.78  E-value: 1.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  75 NTLKVSVLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTG----LIDTHLALILIYVG 150
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgiLPGLGLPALILALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 151 GAIPMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILrTPENYTLAV 230
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG-GGEAPGPGT 161

                        170       180
                 ....*....|....*....|....*...
gi 446945352 231 GLYEMVAKKFGNEFTTFAAGSVLIAIPI 258
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 90-269 2.86e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 69.25  E-value: 2.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   90 AISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLMKGYFDTIPK 169
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  170 ELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAKKFGNEFTTFAA 249
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170       180
                  ....*....|....*....|
gi 446945352  250 gsvLIAIPISILFLSLQKYF 269
Cdd:pfam00528 161 ---LILLLLNLLVDILQRLL 177
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 16-263 1.80e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 39.66  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   16 LVIFVMCAIIFYPLLWIIGSSFNPGDSlsgssiipQNATLDHYRKLLdlENSNYLLWYKNTLKVSVLTMIFSV-LAISFt 94
Cdd:TIGR03262   9 GMILALLLFLLLPLLALLTKSVYDSDG--------DFIGLANFAEYF--ATPGLLQSLGNSLTVSAIVTAIVVpLAFAF- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   95 AYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIY--VGGAIPMNTW-------LMKGYFD 165
Cdd:TIGR03262  78 AYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLLGGFSIYgfWGIVIGEVFYtfphalmILVTALS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  166 TIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIIlrtPENY-TLAVGLYEMVAKKfgNEF 244
Cdd:TIGR03262 158 LADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVI---GGDYnVLATDIYKQVIGQ--QNF 232

                         250
                  ....*....|....*....
gi 446945352  245 TTFAAGSVLIAIPISILFL 263
Cdd:TIGR03262 233 PMGAVVGVLLLLPALLAFG 251
 
Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 1-280 1.41e-147

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 414.55  E-value: 1.41e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   1 MNIKRQKMLRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDSLSGSSIIPQNATLDHYRKLLdlENSNYLLWYKNTLKVS 80
Cdd:COG3833    5 KSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLF--TETPFLRWFLNSLIVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  81 VLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLM 160
Cdd:COG3833   83 VVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 161 KGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAKKF 240
Cdd:COG3833  163 KGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446945352 241 GNEFTTFAAGSVLIAIPISILFLSLQKYFISGLTAGGTKG 280
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 4-280 1.98e-88

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 264.26  E-value: 1.98e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   4 KRQKMLRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDSL--SGSSIIPQNATLDHYRKLLdlENSNYLLWYKNTLKVSV 81
Cdd:COG0395    7 RRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIfsGPPSLLPSEFTLENYRAAF--TDGPFGRYLLNSLIVAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  82 LTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLMK 161
Cdd:COG0395   85 VSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 162 GYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAkKFG 241
Cdd:COG0395  165 QFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQG-QYG 243

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446945352 242 NEFTTFAAGSVLIAIPISILFLSLQKYFISGLTAGGTKG 280
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
9-280 2.05e-63

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 201.09  E-value: 2.05e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   9 LRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDsLSGSSIIPQNATLDHYRKLLDLENSN-----------YLLWYKNTL 77
Cdd:PRK10998  11 LRLFATHLLLLGFIALIMFPLLMVIAISLREGN-FATGSLIPEQISWEHWKLALGFSVEHadgrvtpppfpVLLWLWNSV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  78 KVSVLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGL------IDTHLALILIYVGG 151
Cdd:PRK10998  90 KVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQyipfigLNTHGGVIFAYLGG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 152 aIPMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVG 231
Cdd:PRK10998 170 -IALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVG 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446945352 232 lyemvAKKFGNE----FTTFAAGSVLIAIPISILFLSLQKYFISGLTAGGTKG 280
Cdd:PRK10998 249 -----MQQYLNPqnylWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 13-265 9.90e-31

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 115.21  E-value: 9.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  13 LSYLVIFVMCAIIFYPLLWIIGSSFNPGDSLSgssIIPQNATLDHYRKLLdlENSNYLLWYKNTLKVSVLTMIFSVLAIS 92
Cdd:COG1177    8 LLRLFLALVLLFLYLPILVLVLYSFNDSWFLT---FPPEGFTLRWYAELF--SDPRLLDALLNSLLIALLSTLLATVLGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  93 FTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLMKGYFDTIPKELD 172
Cdd:COG1177   83 PAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARLQGFDPSLE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 173 ESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILaSIILRTPENYTLAVGLYEMVakKFGNEFTTFAAGSV 252
Cdd:COG1177  163 EAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVI-TLFLAGPGVTTLPVYIYSMI--RRGISPEINALSTL 239

                        250
                 ....*....|...
gi 446945352 253 LIAIPISILFLSL 265
Cdd:COG1177  240 LILLSLLLLLLAE 252
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
9-265 4.63e-20

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 89.45  E-value: 4.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   9 LRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGdslsgssiIPQNATLDHYRKLLDleNSNYLLWYKNTLKVSVLTMIFSV 88
Cdd:COG1178  286 WRWLALALCLLLVLLGLLLPLLALLLWSLTKA--------LDDNLTLDNYRFVLL--DPSLLRALLNSLLLALLAALLAV 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  89 LAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFA---ALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLMKGYFD 165
Cdd:COG1178  356 LLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVlglGLLLLFNRPLPLLLYGTLAILVLAYVVRFLPFALRSLEAALA 435

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 166 TIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFIlASIILRTPENYTLAVGLYEMVakkfGNEFT 245
Cdd:COG1178  436 QIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELS-ATLLLRPPGFETLAVLIYQLA----SSGRY 510

                        250       260
                 ....*....|....*....|
gi 446945352 246 TFAAGSVLIAIPISILFLSL 265
Cdd:COG1178  511 GEAAALALLLVLVSLLPVLL 530
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
4-272 2.98e-17

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 81.36  E-value: 2.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   4 KRQKMLRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGdslsgssiipqnatLDHYRKLLdleNSNYLLWY-KNTLKVSVL 82
Cdd:COG1178    3 TRPRRRPRLLLLLLALLLALLVLLPLLALLLRAFTDG--------------LANFWALL---SDPYLWRAlGNTLLLALL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  83 TMIFSVLAISFTAYAFSRYRFVGRKngLLTFLIL--QMIPNFAALIALYVLAQLTGLIDTHLALIL------IY-VGGAI 153
Cdd:COG1178   66 VTLLSLLLGVPLAWLLARTDFPGRR--LLRWLLLlpLALPPYVVALAWIALFGPNGLLNTLLRALFgleppdIYgLGGII 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 154 --------PMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIIlrTPEN 225
Cdd:COG1178  144 lvlvlfnyPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL--GGGY 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 446945352 226 YTLAVGLYEMVAKKFGnefttFAAGSVL--IAIPISILFLSLQKYFISG 272
Cdd:COG1178  222 TTLTTAIYQAWLGDFD-----LGAAAALalVLLLLVLLLLLLERRLRRR 265
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-258 1.43e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 75.78  E-value: 1.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  75 NTLKVSVLTMIFSVLAISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTG----LIDTHLALILIYVG 150
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgiLPGLGLPALILALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 151 GAIPMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILrTPENYTLAV 230
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG-GGEAPGPGT 161

                        170       180
                 ....*....|....*....|....*...
gi 446945352 231 GLYEMVAKKFGNEFTTFAAGSVLIAIPI 258
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALILLLLS 189
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 5-219 7.16e-16

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 75.57  E-value: 7.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   5 RQKMLRLSLSYLVIFVMCAIIFYPLLWIIGSSFNPGDSLSGssiIPQNATLDHYRKLLdlENSNYLLWYKNTLKVSVLTM 84
Cdd:COG1176    6 RRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGG---VVPGFTLENYARLF--TDPLYLKVLLRTLWIALLTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  85 IFSVLaISF-TAYAFSRYRFvGRKNGLLTFLILQMIPNF------------------AALIALYVLAQLTGLIDTHLALI 145
Cdd:COG1176   81 LICLL-LGYpIAYFLARAPP-RWRNLLLLLVILPFWTSFlvrtyawivllgrngllnSLLLALGLIDEPLRLLYTEFAVV 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446945352 146 LIYVGGAIPMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASII 219
Cdd:COG1176  159 IGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALL 232
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 90-269 2.86e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 69.25  E-value: 2.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   90 AISFTAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLMKGYFDTIPK 169
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  170 ELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAKKFGNEFTTFAA 249
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160

                         170       180
                  ....*....|....*....|
gi 446945352  250 gsvLIAIPISILFLSLQKYF 269
Cdd:pfam00528 161 ---LILLLLNLLVDILQRLL 177
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
18-213 5.70e-14

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 70.55  E-value: 5.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  18 IFVMCAIIFYPLLWIIGSSFNPGDSLSGSsiiPQNATLDHYRKLLDleNSNYLLWYKNTLKVSVLTMIFSVLAISFTAYA 97
Cdd:COG1175   28 LLLLLVFVLYPLLYTLYLSFTDWNLLGPP---PEFVGLDNYARLFT--DPRFWNALGNTLLFTVVSVPLQLVLGLLLALL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  98 FSRyRFVGRkNGLLTFLILQMI--PNFAALIALYVLAQLTGLI----------------DTHLALILIyvggaIPMNTWL 159
Cdd:COG1175  103 LNR-KLRGR-GFFRTLFFLPWVisPVVVALIWKWLFNPDYGLLnallgalglepinwlgDPSLALPAV-----IIVTVWK 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446945352 160 MKGYF--------DTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDF 213
Cdd:COG1175  176 GTGFNmliflaglQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVF 237
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
94-273 6.03e-13

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 67.45  E-value: 6.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  94 TAYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPmnTWLMKGYFDTIPKELDE 173
Cdd:PRK10973  98 SAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATA--TFLFRQFFMTLPDELVE 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 174 SARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIILRTPENYTLAVGLYEMVAKKFG-NEFTTFAAGSV 252
Cdd:PRK10973 176 AARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGtTEWNQVMAAML 255

                        170       180
                 ....*....|....*....|.
gi 446945352 253 LIAIPISILFLSLQKYFISGL 273
Cdd:PRK10973 256 LTLIPPVVIVLAMQRAFVRGL 276
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 8-264 5.35e-12

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 64.24  E-value: 5.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   8 MLRLsLSYLVIFVMCAIIFYPLLWIIGSSFNPgdslSGSSIIPQNATLDHYRKLLdlENSNYLLWYKNTLKVSVLTMIFS 87
Cdd:PRK09500   1 MGRL-LRGGFMTLVYAYLYIPIIILIVNSFNS----SRFGINWKGFTTKWYELLF--NNDSLLQAAQHSLTMAVFSATFA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  88 VLAISFTAYAFSRYRFVGRK--NGLLtfLILQMIPNFAALIALYVLAQLTGLIDTHLALILIYVGGAIPMNTWLMKGYFD 165
Cdd:PRK09500  74 TLIGSLTAVALYRYRFRGKKfvSGML--FVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFAHITFCLPFVVVTVYSRLK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 166 TIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIIlRTPENYTLAVGLYEMVakKFGNEFT 245
Cdd:PRK09500 152 GFDVRMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSFTLSLDDVVVSSFV-TGPSYEILPLKIYSMV--KVGVSPE 228

                        250
                 ....*....|....*....
gi 446945352 246 TFAAGSVLIAIPISILFLS 264
Cdd:PRK09500 229 VNALATILLVLSLVLVILS 247
ModB COG4149
ABC-type molybdate transport system, permease component ModB [Inorganic ion transport and ...
 76-264 7.59e-07

ABC-type molybdate transport system, permease component ModB [Inorganic ion transport and metabolism]; ABC-type molybdate transport system, permease component ModB is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 443320 [Multi-domain]  Cd Length: 223  Bit Score: 48.89  E-value: 7.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  76 TLKVSVLTMIFSVLAISFTAYAFSRYRFVGRknGLL-TFLILQMI-PN----FAALIAL-------YVLAQLTG--LIDT 140
Cdd:COG4149   12 SLKVALIATLLLLLLGIPLAWWLARTRFRGK--GLLeALVTLPLVlPPtvlgFYLLLLFgrngplgQLLEELFGisLVFT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352 141 HLALILiyvgGAIPMNTWLM----KGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTF---IGPF--T 211
Cdd:COG4149   90 WTGAVL----ASVVVSLPLMvqplRAAFEAVDPRLEEAARTLGASPWRVFFRVTLPLAKPGILAGAVLAFaraLGEFgaT 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446945352 212 DFILASIILRTPenyTLAVGLYEMVAKkfGNEFTTFAAGSVLIAIPISILFLS 264
Cdd:COG4149  166 LMFAGNIPGKTQ---TLPLAIYDAVEA--GDYAAAHALSLILLAISFVVLLLL 213
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 16-263 1.80e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 39.66  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   16 LVIFVMCAIIFYPLLWIIGSSFNPGDSlsgssiipQNATLDHYRKLLdlENSNYLLWYKNTLKVSVLTMIFSV-LAISFt 94
Cdd:TIGR03262   9 GMILALLLFLLLPLLALLTKSVYDSDG--------DFIGLANFAEYF--ATPGLLQSLGNSLTVSAIVTAIVVpLAFAF- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   95 AYAFSRYRFVGRKNGLLTFLILQMIPNFAALIALYVLAQLTGLIDTHLALILIY--VGGAIPMNTW-------LMKGYFD 165
Cdd:TIGR03262  78 AYALTRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLLGGFSIYgfWGIVIGEVFYtfphalmILVTALS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  166 TIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDFILASIIlrtPENY-TLAVGLYEMVAKKfgNEF 244
Cdd:TIGR03262 158 LADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVI---GGDYnVLATDIYKQVIGQ--QNF 232

                         250
                  ....*....|....*....
gi 446945352  245 TTFAAGSVLIAIPISILFL 263
Cdd:TIGR03262 233 PMGAVVGVLLLLPALLAFG 251
modB PRK09421
molybdate ABC transporter permease subunit;
77-196 6.23e-03

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 37.21  E-value: 6.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352  77 LKVSVLTMIFSV-LAIsFTAYAFSRYRFVGRK--NGLLTF-LILQ-MIPNFAALIAL-------YVLAQLTGLID----T 140
Cdd:PRK09421  15 LKVSSVAVLFSLpFGI-LVAWLLARCRFPGKSllDSLLHLpLVLPpVVTGYLLLISMgrrgfigQWLYEWFGISFafswR 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446945352 141 HLALILIYVggAIPMNTWLMKGYFDTIPKELDESARMDGAGHFRIFWQIIMPLAKP 196
Cdd:PRK09421  94 GAALAAAVM--AFPLMVRAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLPLTLP 147
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 19-235 8.66e-03

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 37.35  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   19 FVMCAIIFYPLLWIIGSSFnpgdslsGSSII---PQNA--TLDHYRklLDLENSNYLLWYKNTLKVSVLTMIFSVLAISF 93
Cdd:TIGR03262 284 LVYCAIISAALLAVVGMAV-------YASLVkfwPYNLslTLKHYN--FDLMDGGGWEAYKNSLRLAATTALIGTILVFG 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446945352   94 TAYAFSRYRFVGRKNGLLTFL-ILQM-IPNFAALIAlYVL------AQLTGLIDTHLALILI-----YVGGAIPMNTWLM 160
Cdd:TIGR03262 355 GAYLIEKTRGFGLLRGVLRFLaILPMaVPGLVLGLG-YIFffnaptNPLNGLYGTMALLVLCtvvhfYTVSHLTAVTALK 433

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446945352  161 KgyfdtIPKELDESARMDGAGHFRIFWQIIMPLAKPIVAVVALFTFIGPFTDfILASIILRTPENYTLAVGLYEM 235
Cdd:TIGR03262 434 Q-----IDSEFEAVSASLKVPFYKTFLRVTLPVCLPAILDIARYLFVNSMTT-VSAVVFLYSPDTKLASVAILNM 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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