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Conserved domains on  [gi|446969659|ref|WP_001046915|]
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MULTISPECIES: amino acid ABC transporter permease [Bacillus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-219 2.91e-87

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 256.54  E-value: 2.91e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   1 MNLDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQ 80
Cdd:COG0765    1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  81 IiGYEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKE 160
Cdd:COG0765   81 L-GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446969659 161 SAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKKSD 219
Cdd:COG0765  160 TSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-219 2.91e-87

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 256.54  E-value: 2.91e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   1 MNLDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQ 80
Cdd:COG0765    1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  81 IiGYEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKE 160
Cdd:COG0765   81 L-GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446969659 161 SAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKKSD 219
Cdd:COG0765  160 TSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
11-219 3.50e-46

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 152.21  E-value: 3.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  11 SIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIiGYEIPAFL 90
Cdd:PRK15100  11 SAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF-GIELDPIP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  91 AAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGAT 170
Cdd:PRK15100  90 AAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446969659 171 DLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKKSD 219
Cdd:PRK15100 170 ELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQE 218
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 12-217 3.08e-30

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 111.09  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   12 IPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPqIIGYEIPAFLA 91
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLP-LIGLSLDPVTT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   92 AVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGATD 171
Cdd:TIGR03004  83 GVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLAD 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 446969659  172 LMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKK 217
Cdd:TIGR03004 163 LTFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 21-206 1.18e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.62  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  21 VTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIIGYEIPA--FLAAVLAFSL 98
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglGLPALILALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  99 NSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGATDLMRRAYI 178
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTG 162

                        170       180
                 ....*....|....*....|....*...
gi 446969659 179 VGGETFKYLEPLLFVGLIYYMLVIILTL 206
Cdd:cd06261  163 LLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 33-217 2.77e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.01  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   33 GFILGTLLALckiARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVpqIIGYEIPAFLAAVLAFSLNSGAYMSEVIRAGI 112
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIA--ILSILGHGILPAIILALLGWAGYARLIRRAAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  113 QAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGATDLMRRAYIVGGETFKY---LEP 189
Cdd:pfam00528  76 RSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYpeiQGP 155

                         170       180
                  ....*....|....*....|....*...
gi 446969659  190 LLFVGLIYYMLVIILTLVGKAIEGRMKK 217
Cdd:pfam00528 156 VLAAALILLLLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-219 2.91e-87

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 256.54  E-value: 2.91e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   1 MNLDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQ 80
Cdd:COG0765    1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  81 IiGYEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKE 160
Cdd:COG0765   81 L-GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446969659 161 SAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKKSD 219
Cdd:COG0765  160 TSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 3-215 1.25e-56

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 179.14  E-value: 1.25e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   3 LDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQII 82
Cdd:COG4160    1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  83 GYEIP--------AFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEF 154
Cdd:COG4160   81 WVRESwlwpllrdPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEV 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446969659 155 ATLTKESAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRM 215
Cdd:COG4160  161 ILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRL 221
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
15-214 6.89e-53

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 169.92  E-value: 6.89e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  15 ILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIIGY---------- 84
Cdd:COG4215   18 LLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGQILLNAladlfgydgf 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  85 -EIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAV 163
Cdd:COG4215   98 iEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDTAL 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446969659 164 VTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGR 214
Cdd:COG4215  178 VSVIGLVDLVRQAQEAAGSTREPFTFYLAAALIYLALTTVSELVLARLERR 228
PRK15100 PRK15100
cystine ABC transporter permease;
11-219 3.50e-46

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 152.21  E-value: 3.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  11 SIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIiGYEIPAFL 90
Cdd:PRK15100  11 SAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF-GIELDPIP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  91 AAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGAT 170
Cdd:PRK15100  90 AAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446969659 171 DLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKKSD 219
Cdd:PRK15100 170 ELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQE 218
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-216 8.36e-43

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 143.66  E-value: 8.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   1 MNLDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQ 80
Cdd:PRK09494   1 MQFDWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  81 II-GYEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTK 159
Cdd:PRK09494  81 AFnDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446969659 160 ESAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMK 216
Cdd:PRK09494 161 DTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMK 217
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
2-207 2.63e-36

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 126.87  E-value: 2.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   2 NLDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVP-- 79
Cdd:PRK15107   3 EFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPgf 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  80 --QIIGYEIPA---FLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEF 154
Cdd:PRK15107  83 lqNVLGLSPKTdirLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQG 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446969659 155 ATLTKESAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLV 207
Cdd:PRK15107 163 IVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLL 215
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 12-217 3.08e-30

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 111.09  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   12 IPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPqIIGYEIPAFLA 91
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLP-LIGLSLDPVTT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   92 AVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGATD 171
Cdd:TIGR03004  83 GVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLAD 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 446969659  172 LMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGRMKK 217
Cdd:TIGR03004 163 LTFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
21-214 2.46e-28

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 106.69  E-value: 2.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  21 VTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQ-------------------- 80
Cdd:PRK11123  13 MTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGSSQllltlsdgftlnlgfvqipv 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  81 ---IIGYEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATL 157
Cdd:PRK11123  93 qmdIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVL 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446969659 158 TKESAVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYYMLVIILTLVGKAIEGR 214
Cdd:PRK11123 173 LKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELR 229
PRK15069 PRK15069
histidine ABC transporter permease HisM;
14-208 9.32e-27

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 102.44  E-value: 9.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  14 YILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIIGYEIPAFLAA- 92
Cdd:PRK15069  18 YRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVRGTDLLDAf 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  93 --------VLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVV 164
Cdd:PRK15069  98 frsglnctILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLA 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446969659 165 TVIGATDLMRRAYIVGGETFKYLEPLLFVGLIYymLVIILTLVG 208
Cdd:PRK15069 178 FTATVPDILKIARDINSATYQPFQAFGIAAVLY--LIISFVLIS 219
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 11-110 5.24e-26

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 96.45  E-value: 5.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   11 SIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQiIGYEIPAFL 90
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPL-IGIRLSPLT 79

                          90       100
                  ....*....|....*....|
gi 446969659   91 AAVLAFSLNSGAYMSEVIRA 110
Cdd:TIGR01726  80 AAVIALTLFYGAYLAEIFRG 99
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 86-173 1.04e-23

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 97.14  E-value: 1.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  86 IPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVT 165
Cdd:COG4597  262 SPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAV 341


                 ....*...
gi 446969659 166 VIGATDLM 173
Cdd:COG4597  342 AIGYPDLV 349
artM PRK11122
arginine ABC transporter permease ArtM;
12-214 4.33e-23

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 92.71  E-value: 4.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  12 IPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIIG-YEIP--- 87
Cdd:PRK11122   5 LPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPWlQEYPwlw 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  88 -----AFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRnIIFPQALKNILPALVNEFATLTKESA 162
Cdd:PRK11122  85 hllsqPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446969659 163 VVTVIGATDLMRRAYIVGGETFkylEPLLFV--GLIYYMLVIILTLVGKAIEGR 214
Cdd:PRK11122 164 LAYTITLMDVMGYSQLLYGRTY---DVMVFGaaGIIYLVVNGLLTLLMRLIERK 214
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
15-197 4.13e-18

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 79.45  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  15 ILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTP-LVLQLMIIY------------FGVPQI 81
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPdLVLMLLIFYglqialnsvteaLGVGQI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  82 igyEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKES 161
Cdd:PRK15135  89 ---DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKAT 165

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446969659 162 AVVTVIGATDLMRRAYIVGGETFKYLEPLLFVGLIY 197
Cdd:PRK15135 166 ALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIY 201
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 21-206 1.18e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.62  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  21 VTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVPQIIGYEIPA--FLAAVLAFSL 98
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglGLPALILALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  99 NSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGATDLMRRAYI 178
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTG 162

                        170       180
                 ....*....|....*....|....*...
gi 446969659 179 VGGETFKYLEPLLFVGLIYYMLVIILTL 206
Cdd:cd06261  163 LLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 33-217 2.77e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.01  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   33 GFILGTLLALckiARIRALNIAADFYTSIFRGTPLVLQLMIIYFGVpqIIGYEIPAFLAAVLAFSLNSGAYMSEVIRAGI 112
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIA--ILSILGHGILPAIILALLGWAGYARLIRRAAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  113 QAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKESAVVTVIGATDLMRRAYIVGGETFKY---LEP 189
Cdd:pfam00528  76 RSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYpeiQGP 155

                         170       180
                  ....*....|....*....|....*...
gi 446969659  190 LLFVGLIYYMLVIILTLVGKAIEGRMKK 217
Cdd:pfam00528 156 VLAAALILLLLNLLVDILQRLLDPRVRK 183
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 13-150 1.43e-07

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 50.53  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  13 PYILKGLEVTLKIVAVSALAGFILGTLLALCkIARIRALNIAADFYTSIFRGTPLV--LQLMIIYFGvpqiIGYEIPAFL 90
Cdd:COG0600   57 GELWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPLalAPLLILWFG----IGEASKIFV 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  91 AAVLAFslnsgAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPAL 150
Cdd:COG0600  132 IFLGAF-----FPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGL 186
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
3-160 1.12e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 39.37  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659   3 LDFSAITPSIPYILKGLEVTLKIVAVSALAGFILGTLLALCKIARIRALNIAADFYTSIFRGTP-LVLQLMIIYFGVPQI 81
Cdd:COG1178  324 LDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPgIVLGLGLLLLFNRPL 403

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446969659  82 IGYEIPAFLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPQALKNILPALVNEFATLTKE 160
Cdd:COG1178  404 PLLLYGTLAILVLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKE 482
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 13-151 9.95e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 36.24  E-value: 9.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  13 PYILKGLEVTLKIVAVSALAGFILGTLLALCkIARIRalniaadfytsiFRGTPLVLQLMIIYFGVPQII---------- 82
Cdd:COG1177   57 PRLLDALLNSLLIALLSTLLATVLGTPAALA-LARYR------------FRGRRLLLALLLLPLVVPGIVlgvallllfs 123

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446969659  83 GYEIPA-FLAAVLAFSLNSGAYMSEVIRAGIQAVDKGQTEAAMALGIPYGKMMRNIIFPqalkNILPALV 151
Cdd:COG1177  124 ALGLSGgLWGLILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLP----LIAPGIL 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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