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Conserved domains on  [gi|446993276|ref|WP_001070532|]
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MULTISPECIES: autorepressor SdpR family transcription factor [Bacillus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 4-82 7.65e-57

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


:

Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 169.13  E-value: 7.65e-57
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446993276  4 AFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLLTWVFTF 82
Cdd:NF033789  1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 4-82 7.65e-57

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 169.13  E-value: 7.65e-57
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446993276  4 AFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLLTWVFTF 82
Cdd:NF033789  1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-82 1.79e-34

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 113.06  E-value: 1.79e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993276  1 MNQAFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLLTWVF 80
Cdd:COG0640  10 LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLL 89


                ..
gi 446993276 81 TF 82
Cdd:COG0640  90 EL 91
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-76 7.35e-34

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 111.01  E-value: 7.35e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276  1 MNQAFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLL 76
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-68 5.39e-26

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 91.21  E-value: 5.39e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446993276  5 FKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLN 68
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-76 5.07e-21

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 78.41  E-value: 5.07e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446993276   15 KILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLL 76
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLL 62
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 10-54 1.22e-18

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 71.71  E-value: 1.22e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446993276  10 DPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELI 54
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 3-67 6.84e-12

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 56.36  E-value: 6.84e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276   3 QAFKALADPTRRKILDLLKE-GDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSL 67
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 4-82 7.65e-57

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 169.13  E-value: 7.65e-57
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446993276  4 AFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLLTWVFTF 82
Cdd:NF033789  1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-82 1.79e-34

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 113.06  E-value: 1.79e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993276  1 MNQAFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLLTWVF 80
Cdd:COG0640  10 LAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLL 89


                ..
gi 446993276 81 TF 82
Cdd:COG0640  90 EL 91
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 1-76 7.35e-34

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 111.01  E-value: 7.35e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276  1 MNQAFKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLL 76
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-68 5.39e-26

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 91.21  E-value: 5.39e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446993276  5 FKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLN 68
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLT 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-76 5.07e-21

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 78.41  E-value: 5.07e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446993276   15 KILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLNTTVFQDLL 76
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLL 62
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 10-54 1.22e-18

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 71.71  E-value: 1.22e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446993276  10 DPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELI 54
Cdd:pfam01022  1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
5-59 3.08e-17

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 69.60  E-value: 3.08e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 446993276  5 FKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKR 59
Cdd:COG4189  13 LKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 3-61 7.12e-16

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 65.25  E-value: 7.12e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446993276   3 QAFKALADPTRRKILDLLKEGD-LTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQ 61
Cdd:pfam12840  2 DVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
5-60 1.15e-15

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 66.21  E-value: 1.15e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276   5 FKALADPTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRG 60
Cdd:COG1777   11 LDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREG 66
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
3-68 5.30e-15

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 65.28  E-value: 5.30e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446993276   3 QAFKALADPTRRKIL-DLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSLN 68
Cdd:COG3398   89 KILAYLRRETPRRILlYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLN 155
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
1-60 2.00e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 59.94  E-value: 2.00e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446993276   1 MNQAFK--ALADPTRRKILDLLKE-GDLTAGEIAEHFNMTKPSISHHLSALKNAELI--QDEKRG 60
Cdd:COG2345    1 MTDTPAlaALADPTRRRILELLKRaGPVTAAELAEALGLTPNAVRRHLDALEEEGLVerETERRG 65
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 3-67 6.84e-12

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 56.36  E-value: 6.84e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276   3 QAFKALADPTRRKILDLLKE-GDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSL 67
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
1-64 8.64e-08

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 47.58  E-value: 8.64e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276   1 MNQAFKALAD-----PTRRKILDLLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELI-QDEKR------GQFVV 64
Cdd:COG4742    1 MGSMKLDLLDflflsEKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIeRDDGEyelttlGRLVV 76
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 14-67 1.25e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 44.52  E-value: 1.25e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 446993276 14 RKILDLLKE--GDLTAGEIAEHFNMTKPSISHHLSALKNAELIQDEKRGQFVVYSL 67
Cdd:COG2512  18 RRVLELLREngGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVEL 73
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-55 4.70e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 39.18  E-value: 4.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446993276   1 MNQAFKALA-DPTRRKILDLL-KEGDLTAGEIAEHFNMTKPSISHHLSALKNAELIQ 55
Cdd:COG1846   27 LDRALAELGlTPAQFRVLAALaEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 19-54 1.56e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.03  E-value: 1.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 446993276  19 LLKEGDLTAGEIAEHFNMTKPSISHHLSALKNAELI 54
Cdd:pfam12802 14 LARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 11-54 1.18e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 35.66  E-value: 1.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446993276  11 PTRRKILDLLKEGDLTAG------EIAEHFNMTKPSISHHLSALKNAELI 54
Cdd:COG1974    6 KRQREILDFIKEYIRERGyppsqrEIAEALGLSSSAVHRHLKALEKKGYL 55
PspF COG1221
Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain ...
 5-48 6.43e-03

Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription, Signal transduction mechanisms];


Pssm-ID: 440834 [Multi-domain]  Cd Length: 835  Bit Score: 33.93  E-value: 6.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446993276   5 FKALADPTRRKILDLLKEGdLTAGEIAEHFNMTKPSISHHLSAL 48
Cdd:COG1221    8 LNYLKELTKNLSLEKKSEG-FTAEEIAEKLGISRNNVSHELNEL 50
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
11-55 8.09e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 32.57  E-value: 8.09e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 446993276    11 PTRRKILDLLKE-GDLTAGEIAEHFNMTKPSISHHLSALKNAELIQ 55
Cdd:smart00347  10 PTQFLVLRILYEeGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVR 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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