|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
26-438 |
0e+00 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 566.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 26 VVATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPG-GDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 106 MALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17366 80 MAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 186 LTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRhldespifeemekaqeesedneqfsfmdilkyhkkDFLLSTVIVAF 265
Cdd:cd17366 160 LTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRR-----------------------------------PLLICIGLVLV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGH 345
Cdd:cd17366 205 FNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGS 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 346 IAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLAGVSI 425
Cdd:cd17366 285 IAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAV 364
|
410
....*....|...
gi 447109680 426 IGLVVFSVLFVTT 438
Cdd:cd17366 365 VGLVAVLFLTETA 377
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
12-462 |
1.07e-147 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 431.06 E-value: 1.07e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 12 QDVNIVNPKQARKAVVATGIGNAMEWFDFGLYAYLAVILSQLFFSGVDnSGLQLVLTFATFAVAFLVRPIGGVFFGRIGD 91
Cdd:PRK10642 4 RDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAD-PSVQMIAALATFSVPFLIRPLGGLFFGMLGD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 92 KYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIG 171
Cdd:PRK10642 83 KYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 172 TLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEE-MEKAQEESEDNEQ----FSFM 246
Cdd:PRK10642 163 SIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQhVDKLEQGDREGLQdgpkVSFK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 247 DILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIG 326
Cdd:PRK10642 243 EIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 327 LLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIfGGTTPLVCSYL 406
Cdd:PRK10642 323 SVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWL 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 447109680 407 VHATGNPLAPAFYLAGVSIIGLVVfSVLFVTTSGRALKGSYPTVESKKEAHQIAKE 462
Cdd:PRK10642 402 VESTQNLMMPAYYLMVVAVIGLIT-GVTMKETANRPLKGATPAASDIQEAKEILVE 456
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
23-429 |
5.69e-131 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 385.34 E-value: 5.69e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 23 RKAVVATGIGNAMEWFDFGLYAYLAV-ILSQLFFSGVDnSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLST 101
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAAlVFNKLFFPAVD-PAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 102 TIILMALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASV 181
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 182 IVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEMEKAQEEsednEQFSFMDILKYHKKDFLLSTV 261
Cdd:cd17369 160 VFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQV----VRAPLVEVLRRHWRALLLAIG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 262 IVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLI 341
Cdd:cd17369 236 LRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 342 GNGHIAAI-FAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYL 420
Cdd:cd17369 316 DTGSTWLIvLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYL 395
|
....*....
gi 447109680 421 AGVSIIGLV 429
Cdd:cd17369 396 AALAVISLV 404
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
32-428 |
1.03e-122 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 363.90 E-value: 1.03e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 32 GNAMEWFDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTL 111
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 112 FIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 192 DEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEemekAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITNY 271
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFE----KAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 272 MILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAF-LLIGNGHIAAIF 350
Cdd:TIGR00883 237 LITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLmALLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447109680 351 AGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLAGVSIIGL 428
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
26-437 |
2.45e-98 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 301.99 E-value: 2.45e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 26 VVATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPS-GSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 106 MALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17368 80 MALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 186 LTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEMEKAQEESEdneqfsFMDILKYHKKDFLLSTVIVAF 265
Cdd:cd17368 160 LSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE------LFALLANNRRIILLGMLLVAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNG- 344
Cdd:cd17368 234 STVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAp 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 345 HIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLAGVS 424
Cdd:cd17368 314 SFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAA 393
|
410
....*....|...
gi 447109680 425 IIGLVVFSVLFVT 437
Cdd:cd17368 394 LLGLLATLMLRET 406
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
26-434 |
1.73e-96 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 296.90 E-value: 1.73e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 26 VVATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPS-GDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 106 MALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 186 LTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEMEKAQEESEdneqfSFMDILKYHKKDFLLSTVIVAF 265
Cdd:cd17367 160 LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASA-----GTLRELRRHPRELLLVVGLTAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNG- 344
Cdd:cd17367 235 GTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTd 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 345 HIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHaTGNPLAPAFYLAGVS 424
Cdd:cd17367 315 SPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKS-IGHEWVFFWYVAGLI 393
|
410
....*....|
gi 447109680 425 IIGLVVFSVL 434
Cdd:cd17367 394 AISLVVYLRM 403
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-430 |
1.23e-78 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 249.06 E-value: 1.23e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 26 VVATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIIL 105
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 106 MALSTLFIALLPTyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTI 185
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 186 LTLLLTDEqmlsWGWRIPFLIAAPIGLVGLYLRRhldespifeemekaqeesedneqfsfmdilkyhkkDFLLSTVIVAF 265
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLRR-----------------------------------RTLLLILLWFF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPaFLLIGNGH 345
Cdd:cd17316 189 ISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP-LFYLLSGS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 346 IAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHaTGNPLAPAFYLAGVSI 425
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS-TGGTGVPALILALLAI 346
|
....*
gi 447109680 426 IGLVV 430
Cdd:cd17316 347 VALIV 351
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
32-442 |
4.87e-71 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 232.14 E-value: 4.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 32 GNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTL 111
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFFPA-GNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 112 FIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 192 DEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEMEKAQEESEdneqfsFMDILKYHKKDFLLSTVIVAFFNITNY 271
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMRE------IFRSLAANWRIVLAGMLMVAMTTVSFY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 272 MILSYIPSYLTQVLKVKETTGLLI---ISITMALMIPLalyFGKLSDKIGNKRVvqigLLGLTVFAI----PAFL-LIGN 343
Cdd:PRK15075 256 LITVYTPTFGKTVLHLSAADSLLVtlcVGVSNFIWLPI---GGALSDRIGRRPV----LIAFTVLAIltayPALSwLVAA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 344 GHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLAGV 423
Cdd:PRK15075 329 PSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAAPGYWLSFA 408
|
410
....*....|....*....
gi 447109680 424 SIIGLVVFSVLFVTTSGRA 442
Cdd:PRK15075 409 AVCGLIATLVLYRRRGARL 427
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
20-430 |
3.55e-66 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 219.60 E-value: 3.55e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 20 KQARKAVVATGIGNAMEWFDFGLYAYLA-VILSQLFFSGVdNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIV 98
Cdd:PRK09952 18 SRARRAALGSFAGAVVDWYDFLLYGITAaLVFNREFFPQV-SPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRM 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 99 LSTTIILMALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:PRK09952 97 LMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 179 ASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEemEKAQEESEDNEQFSFMDILKYHKKDFLL 258
Cdd:PRK09952 177 STGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFE--QQQHEQAAAKKRIPVIEALLRHPGAFLK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKE----TTGLLIISITmALMIPLalyFGKLSDKIGNKRVVQIGLLGLTVFA 334
Cdd:PRK09952 255 IIALRLCELLTMYIVTAFALNYSTQNLGLPRelflNIGLLVGGLS-CLTIPC---FAWLADRFGRRRVYITGALIGTLSA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 335 IPAFLLIGNGHIAAI-FAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHAT-GN 412
Cdd:PRK09952 331 FPFFMALEAQSIFWIvFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFgGS 410
|
410
....*....|....*...
gi 447109680 413 PLAPAFYLAGVSIIGLVV 430
Cdd:PRK09952 411 WHSVAIYLLAGCLISAMT 428
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
25-444 |
1.24e-63 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 212.75 E-value: 1.24e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 25 AVVATGIGNAMEWFDFGLYAYLAVILSQLFFSGvDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTII 104
Cdd:PRK10406 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPS-GNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVC 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 105 LMALSTLFIALLPTYEQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVT 184
Cdd:PRK10406 102 MMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 185 ILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESpifeemeKAQEESEDNEQFSFMDILKyHKKDFLLSTVIVA 264
Cdd:PRK10406 182 VLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-------SQQETRALKEAGSLKGLWR-NRRAFIMVLGFTA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 265 FFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNG 344
Cdd:PRK10406 254 AGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPILSALQNV 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 345 HIAAIFAGIFVLGFFLSVYEGTLPSLLPS-LFFTDVRYRALSISFNISVSIFGGTTPLVCSYLvHATGNPLAPAFYlagV 423
Cdd:PRK10406 334 SSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANALFGGSAEYVALSL-KSIGMETAFFWY---V 409
|
410 420
....*....|....*....|..
gi 447109680 424 SIIGLVVFSV-LFVTTSGRALK 444
Cdd:PRK10406 410 TLMAVVAFLVsLMLHRKGKGMR 431
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-442 |
5.38e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 159.28 E-value: 5.38e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 20 KQARKAVVATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdnsGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVL 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 100 STTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGiLGSGLEIGtlSGYIAA 179
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG-LALGLAAG--GGNLGA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 180 SVIVTILTLLLTdeqmlSWGWRIPFLIAAP-IGLVGLYLRRHLDESPIFEEMEKAQEESEdneqfsFMDILKYhkKDFLL 258
Cdd:COG2223 143 AVAAFLAPLLIA-----AFGWRNAFLILGIlLLVVAVLAWLFLRDPPAGAAAAAKASLRD------QLEALRD--PRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAF 338
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 339 LLIGNghIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISvSIFGGTTPLVCSYLVHATGNPLAPAF 418
Cdd:COG2223 290 LALGS--LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGSYTAAFL 366
|
410 420
....*....|....*....|....
gi 447109680 419 YLAGVSIIGLVVFSVLFVTTSGRA 442
Cdd:COG2223 367 VFAVLALVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-390 |
1.51e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 154.36 E-value: 1.51e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 19 PKQARKAVVATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIV 98
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPAQAGLVVTAYLLGAA-----LGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 99 LSTTIILMALSTLFIALLPTYEqigvwapiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 179 ASVIVTILTLLltdeqmlsWGWRIPFLIAAPIGLVGLYLRRHLdespifeeMEKAQEESEDNEQFSFMDILKYhkKDFLL 258
Cdd:COG2814 150 GPLLGGLLADL--------FGWRWVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRR--PRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 259 STVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLgltVFAIPAF 338
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL---LLALGLL 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447109680 339 LLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNI 390
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-435 |
1.08e-39 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 147.45 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 27 VATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdnsGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILM 106
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEF-------GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 107 ALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTIL 186
Cdd:cd17371 75 AVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 187 TLLLTDEqmlsWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEMEKAQEESEDneQFSFMDIL-KYHKKDFLLSTVIVAF 265
Cdd:cd17371 147 FPLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFAD--RPSLRELFsPPLLRTTLLASLLATG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 266 FNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIG-LLGLTVFAIPAFLLIGNG 344
Cdd:cd17371 221 ALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFaLGSAISILLYFFLPLSPT 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 345 hiaAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIfGGTTPLVCSYLvhATGNPLAPAFYLAGVS 424
Cdd:cd17371 301 ---LILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFL--ATSGSLGTAIAVFAAV 374
|
410
....*....|.
gi 447109680 425 IIGLVVFSVLF 435
Cdd:cd17371 375 YYIAGLVLALL 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-441 |
7.20e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 141.93 E-value: 7.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 20 KQARKAVVATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVltfatFAVAFLVRPIGGVFFGRIGDKYGRKIVL 99
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLL-----ASAFFLGYALGQIPAGLLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 100 STTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAA 179
Cdd:COG2271 79 AIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 180 SVIVTILtllltdeqMLSWGWRIPFLIAAPIGLVGLYLRrhldespifeemekaqeesedneqfsfmdilkyhkkdFLLS 259
Cdd:COG2271 151 PPLLGWL--------LAAFGWRAAFLILGLPGLLLALLR-------------------------------------FWLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 260 TVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVqIGLLGLTVFAIPAFL 339
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL-VLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 340 LIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnpLAPAFY 419
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATG--YQAAFL 341
|
410 420
....*....|....*....|..
gi 447109680 420 LAGVSIIGLVVFSVLFVTTSGR 441
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
24-444 |
1.53e-36 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 140.10 E-value: 1.53e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 24 KAVVATgIGNAMEWFDFGLYAYLAVILSQLFFSGVDNS----GLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVL 99
Cdd:pfam00083 1 VALVAA-LGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSvsslAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 100 STTIILMALSTLFIALLPTYeqigvWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGtlsgyIAA 179
Cdd:pfam00083 80 LIANVLFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLA-----ITF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 180 SVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIF------------------------EEMEKAQE 235
Cdd:pfam00083 150 GILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrleearevlaklrgvpdvdRELDEIKD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 236 ESEDNEQFSFMDI-----LKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKET-TGLLIISITMALMIPLALY 309
Cdd:pfam00083 230 SLEAGQEAEKASWkelfsTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSfLVTIIVGVVNFVFTFIAIF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 310 fgkLSDKIGNKRVVQIGLLG----LTVFAIPAFLLIGNGHIAAIFAGIFVLgFFLSVYE---GTLPSLLPS-LFFTDVRY 381
Cdd:pfam00083 310 ---LVDRFGRRPLLLLGAAGmaicFVILGIVALLGVSKSDWAGIVAIVFIA-LFIAFFAmgwGPVPWVIVSeLFPLSVRS 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447109680 382 RALSISFNISVsIFGGTTPLVCSYLVHATGNPLAPAFYlAGVSIIGLVVFSVLFVTTSGRALK 444
Cdd:pfam00083 386 KAMALATAANW-LANFLIGFLFPIITDAIGLGYTFFIF-AGLLVLFIIFVFFFVPETKGRTLE 446
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-224 |
1.70e-35 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 133.78 E-value: 1.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 19 PKQARKAVVATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLtfatfAVAFLVRPIGGVFFGRIGDKYGRKIV 98
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL--GASSAQLGWIV-----SAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 99 LSTTIILMALSTLFIALLPTyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIA 178
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 447109680 179 ASVIVTILTLLltdeqmlsWGWRIPFLIAAPIGLVGLYLRRHLDES 224
Cdd:COG0477 154 GPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPES 191
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-435 |
6.14e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.29 E-value: 6.14e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 53 LFFSGVDNSGLQLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLV 132
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQL---LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 133 ARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLLltdeqmlsWGWRIPFLIAAPIGL 212
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 213 VGLYLRRHLDESPIFEEMEKAQEESEDNEQFSFMDilkyHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTG 292
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL----RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 293 LLIISITMALMIPLALYFGKLSDKIGNKRVVqigLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLP 372
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLI---LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447109680 373 SLFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnpLAPAFYLAG-VSIIGLVVFSVLF 435
Cdd:cd17325 315 DIVPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAaLLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-386 |
1.82e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.51 E-value: 1.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 37 WFDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALL 116
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYA---LAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 117 PTYEqigvwapiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLlltdeqml 196
Cdd:pfam07690 83 SSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 197 SWGWRIPFLIAAPIGLVGLYLRRHLDESPifeemEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAF-FNITNYMILS 275
Cdd:pfam07690 147 LFGWRAAFLILAILSLLAAVLLLLPRPPP-----ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLlFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 276 YIPSYLtQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFV 355
Cdd:pfam07690 222 YLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
330 340 350
....*....|....*....|....*....|.
gi 447109680 356 LGFFLSVYEGTLPSLLPSLFFTDVRYRALSI 386
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGL 331
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
18-390 |
5.62e-25 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 107.48 E-value: 5.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 18 NPKQaRKAVVATGIGNAMEWFDFGLYAYLAVILSQLFfsgvdnsGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKI 97
Cdd:PRK03893 15 NRAQ-WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF-------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 98 VLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSP----DKKRGILGSGLEIGTL 173
Cdd:PRK03893 87 AMVISIVLFSVGTLACGFAPGY--------WTLFIARLVIGMGMAGEYGSSATYVIESWPkhlrNKASGFLISGFSIGAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 174 SGYIAASVIVtiltllltdeqmLSWGWRIPFLIA-APIgLVGLYLRRHLDESPIFEEMEKAQEESEDneqfsFMDILkYH 252
Cdd:PRK03893 159 VAAQVYSLVV------------PVWGWRALFFIGiLPI-IFALWLRKNLPEAEDWKEKHAGKAPVRT-----MVDIL-YR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 253 KKDFLLSTVIVAF----------FNITNYMILSYIP--------SYLTQVLKVKETTGLLIISITMAL------------ 302
Cdd:PRK03893 220 GEHRIINILLTLAaaaalwfcfaGNLQNAAIVAVLGllcaaifiSFMVQSSGKRWPTGVMLMVVVLFAflyswpiqallp 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 303 ------------MIPLALYF------------GKLSDKIGNKRVVQIGLLGLTVFAIPAFlLIGNGHIAAIFAGIFVLGF 358
Cdd:PRK03893 300 tylktdlgydphTVANVLFFsgfgaavgccvgGFLGDWLGTRKAYVCSLLISQLLIIPVF-AIGGANVWVLGLLLFFQQM 378
|
410 420 430
....*....|....*....|....*....|..
gi 447109680 359 FLSVYEGTLPSLLPSLFFTDVRYRALSISFNI 390
Cdd:PRK03893 379 LGQGISGLLPKLIGGYFDTEQRAAGLGFTYNV 410
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
65-431 |
6.68e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.93 E-value: 6.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 65 LVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLVARMIQGFSTGGE 144
Cdd:cd17324 38 LLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 145 YSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIvtiltllltdeqMLSWGWRIPFLIAAPIGLVGLYLRRh 220
Cdd:cd17324 105 WAIAAAYAADLVPPEKRgraiGLVFSGLTLGLVLGRPLGGLL------------GQLLGWRAAFLAIAVLALLAALLLW- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 221 ldespIFEEMEKAQEESEDNEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITM 300
Cdd:cd17324 172 -----RLLPSLPPKKPGSLGLLSSLLLLLR--NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 301 ALMIPLALYFGKLSDKIGNKRVvqIGLLGLTVFAIPAFLLIGNgHIAAIFAGIFVLGFFLsvyeGTLPSLLPSLFF---T 377
Cdd:cd17324 245 VAGVVGSPLAGRLADRGGRRAL--LIALLLLAAALLLLTLLGP-SPLLLLVGLVLWGLGF----FAAHSALQTRVLrlaP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447109680 378 DVRYRALSI---SFNISVSIFGgttpLVCSYLVHATGNPLAPAFyLAGVSIIGLVVF 431
Cdd:cd17324 318 EARGLASSLylaAYNLGGALGA----ALGGLVLDHGGWAGVGWV-GAALLLLALLLA 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-436 |
7.23e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 99.94 E-value: 7.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 46 LAVILSQLFFS-------------GVDNSGLQLVLTFATFAVAFLVrpiggVFFGRIGDKYGRKIVLSTTIILMALSTLF 112
Cdd:cd17321 3 LAVFLAALDVTivnvalptiardlGASPSQLQWVVNAYLLAFAALL-----LLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 113 IALLPTyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILtl 188
Cdd:cd17321 78 CALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgralGLWGAVVGIGAALGPLLGGLLLELF-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 189 lltdeqmlswGWRIPFLIAAPIGLVGLYLRRHldespifeemekaqeesedneqfsfmdilkyhkkdFLLSTVIVAFFNI 268
Cdd:cd17321 148 ----------GWRWIFLINVPIGLVALLLART-----------------------------------FSGAVLAAFLLGA 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 269 TNYMILSYIPSYLTQVLKVKET-TGLLII--SITMALMIPLAlyfGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGH 345
Cdd:cd17321 183 ALGGLLFLLPLYLQGVLGYSPLqAGLALLplALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSS 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 346 IAAIFAGIFV----LGFFLSVYEGTLPSLLP-------SLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPL 414
Cdd:cd17321 260 VWLLLPGLVLlglgLGLFATPLTNAALSSVPkekagaaSGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSA 339
|
410 420
....*....|....*....|..
gi 447109680 415 APAFYLAGVSIIGLVVFSVLFV 436
Cdd:cd17321 340 AAAAFAAGFHLAFLVAAALALL 361
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
12-407 |
2.34e-22 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 98.58 E-value: 2.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 12 QDVNIVNPKQARKAVVATgIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFATFAVAFlvrpiGGVFFGRIGD 91
Cdd:TIGR00895 6 IRKQPLSRYQWRAIILSF-LIMLMDGYDLAAMGFAAPAISAEW--GLDPVQLGFLFSAGLIGMAF-----GALFFGPLAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 92 KYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSG 167
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgtavGLMFCG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 168 LEIGTLSGYIAASVIVTILtllltdeqmlswGWRIPFLIAAPIGLV-GLYLRRHLDESPIFEEMEK-------------- 232
Cdd:TIGR00895 150 YPIGAAVGGFLAGWLIPVF------------GWRSLFYVGGIAPLLlLLLLMRFLPESIDFLVSKRpetvrrivnaiapq 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 233 --AQEESEDNEQFSFMDILKYHKK-----DFLLSTVIV----AFFNITNYMILSYIPsYLTQVLKVKETTGLLIISITMA 301
Cdd:TIGR00895 218 mqAEAQSALPEQKSTQGTKRSVFKalfqgKTARITVLLwllyFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNF 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 302 LMIPLALYFGKLSDKIGnKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFagIFVLGFFLSVYEGTLPSLLPSLFFTDVRY 381
Cdd:TIGR00895 297 GGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSPTLLLLL--GAIAGFFVNGGQSGLYALMALFYPTAIRA 373
|
410 420
....*....|....*....|....*...
gi 447109680 382 RALSISFNIS--VSIFGgttPLVCSYLV 407
Cdd:TIGR00895 374 TGVGWAIGIGrlGAIIG---PILAGYLL 398
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-435 |
9.27e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 96.85 E-value: 9.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 18 NPKQARKAVVATGIGNAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFatFAVAFLvrpIGGVFFGRIGDKYGRKI 97
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAF--GLSDAQAGLLLFA--FFLGYL---LASLPAGRLIDRFGYKR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 98 VLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILgSGLEIGTLSGYI 177
Cdd:COG0738 75 GLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGAL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 178 AASVIVTILTLLLtdeqmLSWGWRIPFLIAA--PIGLVGLYLRRHLDESpifeemeKAQEESEDNEQFSFMDILKYhkKD 255
Cdd:COG0738 146 LGPLLGGLLILLG-----LSLSWHLPYLILAvlLLLLALLFLRSKLPEI-------EEEEEEAAGSAASLKSLLKN--PR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 256 FLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAI 335
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 336 pAFLLIGNGHIAaiFAGIFVLGFFLSVYEGTLPSLLPSLFftdVRYRALSISFNISVSIFGGTT-PLVCSYLVHATGnpL 414
Cdd:COG0738 292 -LALLAPGPWLA--LIGLALVGLGLSLMFPTIFSLALDGL---GKRTAAAVSAVLIMGIVGGAIgPPLIGFLADAFG--L 363
|
410 420
....*....|....*....|.
gi 447109680 415 APAFYLAGVSIIGLVVFSVLF 435
Cdd:COG0738 364 RAAFLVPLVCYLLILLLALAL 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
72-431 |
1.06e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.73 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 72 FAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVY 151
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 152 IAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLlltdeqMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEME 231
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 232 KAQEESEDNEQFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFG 311
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKN--PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 312 KLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVyegTLPSLLPSLFFTDVRYRALSISFNIS 391
Cdd:cd06174 261 LLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL---PLSFALIAELFPPEIRGTAFGLLNTF 337
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 447109680 392 VSIFGGTTPLVCSYLVHATGNPLAPAFYLAGVSIIGLVVF 431
Cdd:cd06174 338 GFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-436 |
2.39e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 93.43 E-value: 2.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 18 NPKQARKAVVATGIGN-AMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFATFAVAFlVRPIGGVFFGRIGDKYG-R 95
Cdd:COG2211 4 KKKLSLKEKLAYGLGDlGLNLAFGLLSAYLLYFYTDVL--GLSAALVGLILLVARLWDAI-TDPLIGALSDRTRTRWGrR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 96 KIVLSTTIILMALSTLFIALLPTYEQIG--VWAPILLLVARMIqgfstggeYSGAMV----YIAESSPD-KKRGILGSGL 168
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLA--------YTLVNIpysaLGAELTPDyEERTRLSSWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 169 EIGTLSGYIAASVIVTILTLLLTDEQmlSWGWRIPFLIAAPIGLVGLYL-RRHLDESPIFEEmekaqeesednEQFSFMD 247
Cdd:COG2211 153 FAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLLtFFGTKERPVPEE-----------EKVSLKE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 248 ILKY--HKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQI 325
Cdd:COG2211 220 SLKAllKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 326 GLLGLTVFAIpAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLP-----SLFFTDVRYRALSIS-FNISVSIFGGTT 399
Cdd:COG2211 300 GLLLAALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdyDEWKTGRRREGLYFGiFTFAIKLGQALA 378
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 447109680 400 PLVCSYLVHATG---NPLAPAFYLAGVSIIGLVVFSVLFV 436
Cdd:COG2211 379 GALAGLLLALFGyvaGAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
17-406 |
3.34e-19 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 89.60 E-value: 3.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 17 VNPKQaRKAVVATGIGNAMEWFDFGLYAYLAVILsqlffsgvdNSGLQLVLTFATF--AVAFLVRPIGGVFFGRIGDKYG 94
Cdd:PRK12307 12 ITRPQ-KNALFSAWLGYVFDGFDFMLIFYIMYLI---------KADLGLTDMEGAFlaTAAFIGRPFGGALFGLLADKFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 95 RKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSP----DKKRGILGSGLEI 170
Cdd:PRK12307 82 RKPLMMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPkhlkSKASAFLVSGFGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 171 GTLsgyIAASVIVTILTllltdeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEME---KAQEESEDNEQFSFMD 247
Cdd:PRK12307 154 GNI---IAAYFMPSFAE---------AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgKGKHSQSAWSVFSLSM 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 248 ILKYHKKDFLLS-TVIVAFFNI--TNYMILSYIPSYLTQvlkvkETTGLLIISITMAL----MIPLALYFGKLSDKIGNK 320
Cdd:PRK12307 222 KGLFNRAQFPLTlCVFIVLFSIfgANWPIFGLLPTYLAG-----EGFDTGVVSNLMTAaafgTVLGNIVWGLCADRIGLK 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 321 RVVQIGLLGLTVFAIPAFlLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSifGGT-T 399
Cdd:PRK12307 297 KTFSIGLLMSFLFIFPLF-RIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAAT--SGTfN 373
|
....*..
gi 447109680 400 PLVCSYL 406
Cdd:PRK12307 374 SMAATWL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-431 |
2.60e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 83.39 E-value: 2.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSGLQLVLTFATFAVAFLvrpigGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLVARMI 136
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVL-----MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVtiltllltdeqmlSWGWRIPFLIAAPIGL 212
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGGLLA-------------AISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 213 VGLYLRRHLDEspifeemEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTG 292
Cdd:cd17474 164 VAFLAILFLLP-------EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 293 LLIISITMALMIPLALYFGKLSDK-IGNKRVVQIGLLGLTVfaipAFLLIGNGH-IAAIFAGIFVLGFFLSVYEGTLPSL 370
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYAL----SLLLLGFVPsLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447109680 371 LPSLFFTDvrYRALSISFNISVSIFGGTT-PLVCSYLVHATGNPlAPAFYLAGVSIIGLVVF 431
Cdd:cd17474 313 VTELAPEE--ERGTASSLYNFVRFLGQAVgPLLFGLLLEIFGLS-APFLVGAAIALAAAVLL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
64-430 |
3.34e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 83.00 E-value: 3.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 64 QLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALlptyeqigVWAPILLLVARMIQGFSTGG 143
Cdd:cd17319 39 QYGLIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF--------ATSLTSLYVLRFLLGVAEAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 144 EYSGAMVYIAESSPDKKRGiLGSGLeigTLSGYIAASVIVTILTLLLtdeqMLSWGWRIPFLIAAPIGLVglylrrhlde 223
Cdd:cd17319 108 FFPGAIKALAEWFPARERG-RATGL---FNSGAPLGAAIGPPLSGWL----LLLFGWRWAFIIEGLLGLL---------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 224 spifeemekaqeesedneqFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALM 303
Cdd:cd17319 170 -------------------LAVLWWFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 304 IPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFftDVRYRA 383
Cdd:cd17319 229 AIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL--PGEAAA 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 447109680 384 LSISFNISVSIFGG-TTPLVCSYLVHATGNPLAPAFYLAGVSIIGLVV 430
Cdd:cd17319 307 TAGGLINSGGNLGGfVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
26-361 |
1.56e-16 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 81.17 E-value: 1.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 26 VVATGIGNAMEWFDFGLYAYLAVILSQLFFS--GVDNSGLQLVLTfatfAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTI 103
Cdd:cd17364 1 IIIAGMGFFTDAYDLFSISLVTKILGRLYYGgkGSLPSGVSGLVN----AAALVGTIIGQLFFGFLGDRFGRKRVYGVEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 104 ILMALSTLFIALLPTYEQIGVWApiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGIL----GSGLEIGTLSGYIAA 179
Cdd:cd17364 77 IIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAGAIVT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 180 SVIVTIL--TLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLdespifeemekaqeesedneqfsfmdilkyhkkdfL 257
Cdd:cd17364 155 LILSAIFehPLPAGTYHHADLVWRIVLGLGAIPALSVLYFRKHL-----------------------------------L 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 258 LSTVIVAFFNITNYMILSYIPSYLTQV--LKVKETTGLLIISITMALMIPLALYF------GKLSDKIGNKRVVQIGLLG 329
Cdd:cd17364 200 GTAGTWFLLDIAFYGQNLFQSTIISAIgfSKTMNAYQELFNIAVGQLIIALAGTVpgywftVFLIDRIGRKKIQMMGFFG 279
|
330 340 350
....*....|....*....|....*....|...
gi 447109680 330 LTVF-AIPAFLLIGNGHIAAIFAGIFVLGFFLS 361
Cdd:cd17364 280 MTIFlLILAGPYDHWKISTIGFFVLYGLTFFFS 312
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-435 |
3.03e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 80.31 E-value: 3.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 46 LAVILSQLFFSGVDNSGL--QLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqig 123
Cdd:cd17473 18 IAPALPAIAQHFVPNSELlvPLLLTLPALFIA-----LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 124 vwapiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRgilgsgleiGTLSGYIAASVIVTILTLLLTDEQMLSWGWRIP 203
Cdd:cd17473 90 -----ALLASRALLGIGVAGIMTLATALIGDYFEGEER---------AKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 204 FLI---AAPIG-LVGLYLRrhldespifeemEKAQEESEDNEQFSFMdILKYHKKDFLLSTVIVAFFNITNYMILSYIPS 279
Cdd:cd17473 156 FLVyllALPVLiLVLLFLP------------EPARKSKSAASPGAAT-AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 280 YLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVqigLLGLTVFAIpAFLLIG-NGHIAAIFAGIFVLGF 358
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL---AIGFALMAL-GFLLLAlASGLWVVLLGAILAGL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447109680 359 FLSVYEGTLPSLLPSLFFTDVRYRALSIsfnISVSIFGG--TTPLVCSYLVHATGNPLApAFYLAGVSIIGLVVFSVLF 435
Cdd:cd17473 299 GFGLLLPTLNSWAMSLVPPELRGRAMGI---VTSAFFLGqfLSPLVLGPLVNLTGGLSG-AFLILGVLALVLAIVLLLL 373
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
67-431 |
2.11e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.63 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 67 LTFATFAVAFLVRPiggvFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvwaPILLLVARMIQGFSTGGEYS 146
Cdd:cd17489 36 VVGLFTLAALLARP----FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 147 GAMVYIAESSPDKKRgilGSGLEIGTLSGYIAAsVIVTILTLLLTDEqmlsWGWRIPFLIAAPIGLVGLYLrrhldeSPI 226
Cdd:cd17489 104 AAATLVADIIPPSRR---GEGIGYYGLATTLAM-ALGPALGLFLYQH----LGFAVLFIVAAVLALLALLL------VFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 227 FEEMEKAQEESEDNEQFSFMDILkyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPL 306
Cdd:cd17489 170 VKDPPPVAAEEAEAGTRAFRRLV---EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 307 alyFGKLSDKIGNKRVVQIGLLgLTVFAIPAFLLIGNGHIAAIFAGIFVLGFflsvyeGTLPSLLPSLFFTDV----RYR 382
Cdd:cd17489 247 ---SGKLSDRKGPKTVIIPGLL-LLALGLLLLSFAGSPWMLLLAAVLYGLGF------GLLFPALQALAVDLVpphrRGA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 447109680 383 ALSIsFNISVSIFGGTTPLVCSYLVHATGNPlAPAFYLAGVSIIGLVVF 431
Cdd:cd17489 317 ANGT-FFIFFDLGIGLGGLLLGLVAELFGYR-AMFLLAAVVVLLALVLY 363
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
70-336 |
1.85e-14 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 74.61 E-value: 1.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 70 ATFAVAFLVRPIGGvffgRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTgGEYSGAM 149
Cdd:cd17391 44 STFLVSAIFSPIWG----RLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGVFS-GYVPNAT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 150 VYIAESSPDKKrgilgSGLEIGTLS-GYIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLrrhldesPIFE 228
Cdd:cd17391 111 ALIASQTPKEK-----SGWALGTLStGVVAGTLIGPLLGGFLAD----LFGIRNVFFITGGLLFLAFLL-------TLFF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 229 EMEKAQEESEDnEQFSFMDILKYHKKDFLLSTVIVAFF--NITNYMILSYIPSY---LTQVLKVKETTGLLIISITMALM 303
Cdd:cd17391 175 VKEDFKPVEKK-KMVSTKEVWNSVPNPSLLISLFVTTFiiQLANQSIEPILTLYirqLMGDASNLAFISGLVFSATGVSS 253
|
250 260 270
....*....|....*....|....*....|...
gi 447109680 304 IPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIP 336
Cdd:cd17391 254 LLSAPRLGKLGDRIGHHRILLGALLASALLYIP 286
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
57-361 |
3.99e-14 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 73.76 E-value: 3.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSGLQLVLTFATFAVAFLVrPIGGVffgrIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMI 136
Cdd:cd17503 27 GASLDTVQWVITSYLLALAIMI-PLSGW----LADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKKRGilgSGLEIGTLSGyIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLY 216
Cdd:cd17503 94 QGFGGGVLIPLAQTILLRIYPPEKRG---AAMGLVGLVI-LLAPAIGPTLGGWLTD----NLSWRWIFYINLPIGILALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 217 LrrhldeSPIFEemekaqeesedneqfsfMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVK-ETTGLLI 295
Cdd:cd17503 166 L------APLLD-----------------LRLFKD--RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSaFESGLVL 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447109680 296 I--SITMALMIPLAlyfGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLS 361
Cdd:cd17503 221 ApgGLASAILSPLV---GRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMG 285
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
81-436 |
2.07e-13 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 71.45 E-value: 2.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSGLEIGTLSGYIAASVIVTILtllltdEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIfeemekaqeesedn 240
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLAL------SLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 241 eqfsfmdilkyhkkdFLLSTVIVAFFNIT--NyMILSYIPSYLTQVLkvKETTGLLIISITMALMIPLALYFGKLSDKIG 318
Cdd:cd17315 181 ---------------LLVGVGLQLLQQLTgiN-AVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 319 NKRVVQIGLLGLTVFAIP---AFLLIGNGHIAAIFAGIFVLGFFL--SVYEGTLPSLLPS-LFFTDVRYRALSISFNISv 392
Cdd:cd17315 243 RRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLALLGILLYIAafAMGAGPVPWLLLSeIFPLRIRGKGMAIATLVN- 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447109680 393 sifggttpLVCSYLVHATGNPLAPAFYLAGVSII--GLVVFSVLFV 436
Cdd:cd17315 322 --------WIFNFIVGLTFLIMVSTIGLAGVFIFfaAVCLLALVFV 359
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-439 |
2.54e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 71.07 E-value: 2.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 25 AVVATGIGNAMewfdfgLYAYLAVILSQLffsGVDNSGLQLVLTfATFAVAFLVRPIggvfFGRIGDKYGRKIVLSTTII 104
Cdd:cd17504 4 AALAVMLVETM------LSPALPTIQREF---GTSAAAVSWVLT-AYLLVGAVSTPI----LGRLGDLYGRKKVLLIVLA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 105 LMALSTLFIALLPTYEqigvwapiLLLVARMIQGFstggeySGAMVYIA-----ESSPDKKR----GILGSGLEIGTLSG 175
Cdd:cd17504 70 IYTAGSLLAAFAPNLP--------VLIAGRALQGI------GGAVFPLAfalvrEEFPPERVpvaqGILSATFGIGAGIG 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 176 YIAASVIVTILtllltdeqmlswGWRIPFLIAAPIGLVGLYLrrhldeSPIfeemekaqeesedneqfsfMDILKYHKKD 255
Cdd:cd17504 136 LPLGGWIVQHL------------GWRWIFWTAAPVAVLLAAL------VPL-------------------IDLRLLRRRN 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 256 FLLSTVIVAFFNITNYMILSYIPSYLTQvlkVKETTGLLIISITMALMIPLAL-------YFGKLSDKIGNKRVVQIGLL 328
Cdd:cd17504 179 VLLANITALLAGFGMFMVFQLLPQLLQL---PTPTGFGLGITEAGLLLLPGALvmliagpLAGRLIARVGPRRVLLIGLV 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 329 GLTVFAipAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLpsLFFTDVRYRALSISFNISVSIFG--------GTTP 400
Cdd:cd17504 256 ISAVGL--LLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV--VESVPPDRTGIATGMNTVLRTIGsaigpaiaGAIL 331
|
410 420 430
....*....|....*....|....*....|....*....
gi 447109680 401 LVCSYLVHATGNPLAPAFYLAGVSIIGLVVFSVLFVTTS 439
Cdd:cd17504 332 TTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-434 |
3.92e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 70.31 E-value: 3.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 33 NAMEWFDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLF 112
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDW--GLSPAQLGPVGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 113 IALLPTYEQIGVWapilllvaRMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSgleiGTLSGYIAASVIVTILTLLLTD 192
Cdd:cd17365 81 TAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVT----LMFCGYPLGAALGGFLAAALIP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 193 eqmlSWGWRIPFLIAAPIGLVGLYLrrhldespifeemekaqeesedneqfsfmdilkyhkkdfLLSTVI--VAFFN--I 268
Cdd:cd17365 149 ----AFGWRSVFLLGGVPPLILLPL---------------------------------------LRGTLLlwVTFFMglL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 269 TNYMILSYIPSYLtqvlkvkETTGL-LIISITMALMIPL-----ALYFGKLSDKIGNKRVVqIGLLGLTVFAIPAFLLIG 342
Cdd:cd17365 186 LVYLLNSWLPKLM-------VEAGYsLSQALTITLLLNIggvigSLLLGWLADRFGPKRVL-ALFFALGAVSLALLGVSP 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 343 NGhIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVryRALSISFNISVSIFGGTT-PLVCSYLVHATGNPLAPAFYLA 421
Cdd:cd17365 258 AS-LVLLYVLVFLAGACVNGAQVGLYALAARFYPTEV--RATGVGWALGVGRLGAILgPLLGGLLLAAGLGPESVFLALA 334
|
410
....*....|...
gi 447109680 422 GVSIIGLVVFSVL 434
Cdd:cd17365 335 IPAALGALAVLLL 347
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
81-436 |
6.15e-13 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 70.37 E-value: 6.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALlptyeQIGVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSGLEIGTLSGYIAASVIVtiLTLLLTDEQmlswGWRIPFLIAAPIGLVGLYLRRHLDESPIF------------- 227
Cdd:cd17357 139 RGALGSLTQIGVTLGILLGQVFG--LPSVLGTET----LWPYLLFFPGIPALLQLAALPFFPESPKFlliskgdeeeaek 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 228 ----------------EEMEKAQEESEDNEQFSFMDILK---YHKKdfLLSTVIVAFFNITN--YMILSYIPSYLTQV-L 285
Cdd:cd17357 213 slkflrgieddvdqelEEIKKESEQMGDQKQVSLMQLLRdpsLRLP--LLLVLVVSASQQFSgiNAIFFYSTFIFENAgF 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 286 KVKE----TTGLLIISITMALMIPLALyfgklsDKIGNKRVVQIGLLG----LTVFAIPAFLLIGNGHIAAIFAG-IFVL 356
Cdd:cd17357 291 SPQLaewaNLGIGIVNVLSTIVGPFLI------EKVGRRPLLLISLSVcavaLLLMSVFLFLSEQNSWMSYGCIVaIFLF 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 357 GFFLSVYEGTLPSLLPSLFFTDvRYRALSISFnisvsifggttplvcSYLVHATGNPLAPAFYLAGVSIIGLVVFsVLFV 436
Cdd:cd17357 365 IFFFAIGLGPIPWFIGAELFPQ-APRSAAQSL---------------GSSVNWTSNFIVGMAFPPLQSIGGGFVF-IIFA 427
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
57-431 |
1.73e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.80 E-value: 1.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSgLQLVLTFAtFAVAFLVrpiGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMI 136
Cdd:cd17328 30 LIDDS-LAGLLQTV-FIISYMV---LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTiltllltdeqmLSWGWRIPFLIAAPIGL 212
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRtralGVFYFAIPLGSGLGYVVGGLVAQ-----------ATGGWRWAFRVTGVLGV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 213 V-GLYLRRHLDESPIFEEMEKAQEESEDNeqfSFMDILKY--HKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKE 289
Cdd:cd17328 166 LlAILLLLFVREPPRGAAEGGVMAKSTAT---SFLADLKAlaKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 290 TT----GLLIISITMALMIPLALYFGKLSDKIGNKR------VVQIGLLGLTVFAIPAFLLiGNGHIAAIFAGIFVLGFF 359
Cdd:cd17328 243 LSsadvGLIFGAITCIAGVLGVLLGGILADRLRRKTpradplVCAVGLLAAAPFLFLALVL-ALSNLLLAWVLLFLGEFL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 360 LSVYEG-----TLPSLLPSLfftdvryRALSISFNISVS-IFGGTTP-----LVCSYLVHATGNPLAPA-------FYLA 421
Cdd:cd17328 322 LSLNWApvfaiLLYVVIPTR-------RSTASAIQILLShLLGDAGSpyligLISDLLRQNKDSPLAEAaslqyalLLCS 394
|
410
....*....|
gi 447109680 422 GVSIIGLVVF 431
Cdd:cd17328 395 FVLVLGGFFF 404
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
57-430 |
4.49e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.59 E-value: 4.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSGLQLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMI 136
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFG-----LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKkrgilgsgleIGTLSG-YIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGL 215
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFPDR----------VGLMTGlYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLAL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 216 YLRRhldesPIFEEMEKAQEESEDNEQFSFMdilkYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQvLKVKETTGLLI 295
Cdd:COG2807 186 LLWL-----PLLRRRPAAAAAAPAAASLRSL----WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 296 ISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGH--IAAIFAGIFVLGFFlsvyegTLPSLLPS 373
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLpwLWAVLLGLGQGGLF------PLALTLIG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 447109680 374 LFFTDVRYRALSISFNISVS-IFGGTTPLVCSYLVHATGNPLAPAFYLAGVSIIGLVV 430
Cdd:COG2807 330 LRARTPAEAAALSGMAQSVGyLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
66-361 |
5.31e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.20 E-value: 5.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 66 VLTFATFAVAFLVRPiggvFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEY 145
Cdd:cd17478 35 LLVSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY--------WLLLLLVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 146 SGAMVYIAESSPDKKrgilGSGLEIGTLSGYIAASVIVTILTLLLTdeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESP 225
Cdd:cd17478 103 PEGARLASQAAGGRR----GLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 226 IFEEMEKAQEESedneqfsFMDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIP 305
Cdd:cd17478 174 KPEAKKAAAKSS-------ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 447109680 306 lALYFGKLSDKIGNKRVVQIGLLGltvfAIPAFLLIGNGHIAAIFAGIFVLGFFLS 361
Cdd:cd17478 247 -TLIGGPLSDRFGRRRVIIASLLL----AAPFLLLFLLTPGIWSYILLVLAGFLLF 297
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
81-387 |
5.49e-12 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 67.21 E-value: 5.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSGLEIGTLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRRHLDESPIFeemekaqeesedn 240
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 241 eqfsfmdiLKYHKKDFLLSTVIVAFFN--ITNYMILSYIPSYLTQVlKVKETTGLL---IISITMALMIPLALYfgkLSD 315
Cdd:cd17359 190 --------LVSKGKPILIIGIGLAIFQqfVGINVIFYYGPEIFQNA-GFSENAALLqtiGIGVVNVIFTIIAIL---LVD 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447109680 316 KIGNKRVVQIGLLGLTVFAI---PAFLLIGNGHIAAIFAGIFVLgFFLSVYEGTLPS----LLPSLFFTDVRYRALSIS 387
Cdd:cd17359 258 KVGRKPLLLIGSIGMAISLLligTAFYFAPGSQASGIVALVLIL-LFVAFFAMSWGPvtwvLLSEIFPNRIRGLAMGIA 335
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-435 |
5.81e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 67.26 E-value: 5.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 25 AVVATGIGNAMEWFDFGLYAYlavilsqlffsGVDNSGLQLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTII 104
Cdd:cd06173 7 AQLLSALGDWIFTVALPWLVL-----------QLTGSALLVGLVLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 105 LMALSTLFIALLPTYEQIGVWAPILLLVARMIQG-FSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIV 183
Cdd:cd06173 73 LRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 184 TILtllltdeqmlswGWRIPFLIAAPIGLVGLYLrrhldESPIFEEMEKAQEESEDNEQFSFMDILKYHKKDFLLSTVI- 262
Cdd:cd06173 153 ALL------------GPGGAFAINALSFLLSALL-----LLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLl 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 263 -VAFFNITNYMILSYIPSYLTQVLKVKETT-GLL--IISITMALMiplALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAF 338
Cdd:cd06173 216 aLALFALLGGALTVLLPLLAKEVLGGGAAGyGLLlaAFGVGALLG---ALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 339 LLignGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnpLAPAF 418
Cdd:cd06173 293 LS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV-YNALNSGAMPLGALLAGLLADALG--LSAVF 366
|
410
....*....|....*..
gi 447109680 419 YLAGVSIIGLVVFSVLF 435
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-431 |
2.04e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 65.29 E-value: 2.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSGLQLVLTfaTFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMI 136
Cdd:cd17320 30 GASASAVQLTLS--AYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIvtiltllltdeqMLSWGWRIPFLIAAPIGL 212
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDLYSGAELakifSLLMMILAIAPALAPLLGGLL------------LLFFGWRAIFVFLALLGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 213 V--GLYLRRhldespiFEEMEKAQEESEDNEQF--SFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKV- 287
Cdd:cd17320 165 LllLLVLLF-------LPETLPEEKRKPLLSSLlrAYKRVLK--NRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLs 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 288 KETTGLLIISITMALMIpLALYFGKLSDKIGNKRVVQIGLLGLTV--FAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEG 365
Cdd:cd17320 236 PAQFGLLFALNAIALIL-GSLLNGRLVRRFGPRRLLRLGLLLLLAaaLVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFP 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447109680 366 TLPSLLPSLfFTDVRYRALSISFNISVSIFGGTTPLVcSYLVHATGNPLAPAFYLAGVSIIGLVVF 431
Cdd:cd17320 315 NATSLALEP-FPHVAGTASALLGFLQFLIGALAGALV-GLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
67-430 |
4.47e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 64.14 E-value: 4.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 67 LTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLVARMIQGFSTGGEYS 146
Cdd:cd17317 29 LVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 147 GAMVYIAESSPDKKRGILGSGLEIGTLSGYiaasVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYlrrhldespi 226
Cdd:cd17317 98 VGFVLGMEIVGPKYRSFVGILFGLFWALGY----MLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLPR---------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 227 feemekaqeesedneqfsfmdilkyhkkdfllSTVIVAFFNITNYMIlsyipsYLTQVLKVKETTG-LLIISITMALMIP 305
Cdd:cd17317 164 --------------------------------RTIIVGLIWFVTSLV------YYGLSLNSSNLGGnLYLNFFLSGLVEI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 306 LALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALS 385
Cdd:cd17317 206 PAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVG 285
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 447109680 386 isfniSVSIFGGTTPLVCSYLVH-ATGNPLAPAFYLAGVSIIGLVV 430
Cdd:cd17317 286 -----LCSTVARVGAILAPFIVLlGKIGPLLPLIIFGVLALLGGLL 326
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-431 |
5.57e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.10 E-value: 5.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 41 GLYAYLAVILSQLffsGVDNSGLQLVLTFATFaVAFLVRpiggVFFGRIGDKYG-RKIVLSTTIILMALSTLFIALLPTY 119
Cdd:cd17370 17 MARSILPLFLVVL---GASAAAVGLIEGLAEA-LGSLLR----LFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 120 EqigvWAPILLLVARMIQGFSTggeySGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILtllltdeqm 195
Cdd:cd17370 89 Q----LVLLLRILERLGKGIRT----PPRDALLADATPPSGRgkafGLHRALDTLGAVLGPLLAALLLYLL--------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 196 lSWGWRIPFLIAAPIGLVGLYLrrhldespIFEEMEKAQEESEDNEQFSFMDILKYhKKDFLLSTVIVAFFNITNYmilS 275
Cdd:cd17370 152 -GGNYRTIFLLAAIPALLALLI--------LLFVVKEYPRPPKLRKKSKKTSLKKL-PKAFWLYLLAVALFALGNF---S 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 276 YI-PSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVqigLLGLTVFAIPAFLLIGNGHIAAIFAGIF 354
Cdd:cd17370 219 FAfLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLL---ILGYLSLALAYLGFALGSSLWLLLLGFI 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447109680 355 VLGFFLSVYEGTLPSLLPSLFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGnPLAPAFYLAGVSIIGLVVF 431
Cdd:cd17370 296 LWGLYMGAQESIERAAVADLVPAELRGTAYGL-FNTVVGIGWLLASLIAGYLWDLIS-PSAAFLFSAVLALIALLLL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
72-431 |
6.37e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.83 E-value: 6.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 72 FAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapiLLLVARMIQGFSTGGEYSGAMVY 151
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLLGGGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 152 IAESSPDKKRGIlgsGLEIGTLSGYIAASVIVTILTLLLTDeqmlsWGWRIPFLIAAPIGL-----VGLYLRRHLDespi 226
Cdd:cd17355 117 VAAWWFERRRGL---ALGILTAGGGLGSLVFLPLGAALIEA-----FGWRTALLVLALLALlvlvpVLLLLRRRPA---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 227 feemEKAQEESEDNEQFSFMDILKYHKKD--FLLSTVIVAFFNITNYMILSYIPSYLTQvLKVKETTGLLIISITMALMI 304
Cdd:cd17355 185 ----DLALRAYDDASPASPGSTLKEALRSasFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 305 PLALYFGKLSDKIGNKRVVqIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSvyEGTLPSLLPSLFFTDVRYRAL 384
Cdd:cd17355 260 VGRLLSGWLGDRYSPRRLL-AASYALRALGLALLLLLPFPPLALLLFAALFGLGWGA--TVPLTAALAARYFGARSYGTL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 447109680 385 SISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLAGVSIIGLVVF 431
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
85-358 |
5.29e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 60.65 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 85 FFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGIL 164
Cdd:cd17502 49 IYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 165 gsgleIGTLSG-YIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLRRhldespifeemekaqeesedneqf 243
Cdd:cd17502 121 -----QGYIGAvFGIASVAGPLIGGAFTD----HLSWRWCFYINLPIGGLALALLR------------------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 244 sfmdilkyhkkDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKET-TGLLIISITMALMIpLALYFGKLSDKIGN-KR 321
Cdd:cd17502 168 -----------TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATkSGVRLLPLIIGLVI-GSIISGALISKTGRyKP 235
|
250 260 270
....*....|....*....|....*....|....*..
gi 447109680 322 VVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGF 358
Cdd:cd17502 236 LIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGL 272
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
80-443 |
4.24e-09 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 58.36 E-value: 4.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 80 PIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWM--------LYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 160 KRGILGSGLE----IGTLSGYIAASVI----VTILTLLLTDEQMLSwgwrIPFLIAAPIGLVG-----------LYLR-R 219
Cdd:cd17358 127 VRGALGSLNQllvnIGILLGYVLGSFLpwrtLALIGAIPPVVFLIL----LFFIPESPRWLAKkgreeeaekslQFLRgK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 220 HLDESPIFEEMEKAQEESEDNEQFSFMDILKYHK--KDFLLSTVIVAF------FNITNYMilSYIPSYLTQVLKVKetT 291
Cdd:cd17358 203 DADISKEAAEIQEELAELEKEAKESSFSDLFQRKylKPLVIGLGLMLFqqlsgiNAVIFYA--SSIFDEAGSGLDPN--T 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 292 GLLIISITMALMIPLALYfgkLSDKIGNKR--VVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLG------FFLSVY 363
Cdd:cd17358 279 ATIIIGVVQVVGTLVATL---LVDRLGRRPllLVSAIGMGIGLLALGLYFYLQEHGALLSSVSWLPLVglviyiISFSIG 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 364 EGTLPSLLPS-LFFTDVRYRALSI---SFNISVSIFGGTTPLVCSYLvhatgNPLAPAFYLAGVSIIGLvVFSVLFV-TT 438
Cdd:cd17358 356 LGPLPWVIMSeIFPAKIKGLAGSLvtlVNWLFAFIVTKTFPFLTLAW-----GASGTFWIFAGICGLAL-VFVLLFVpET 429
|
....*
gi 447109680 439 SGRAL 443
Cdd:cd17358 430 KGKSL 434
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-432 |
5.79e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.63 E-value: 5.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 62 GLQLVLTFATFAVAF--LVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWapiLLLVarmiqGF 139
Cdd:cd17475 25 DLHLSLAQVGLLLSAlnLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVL---LFLV-----GA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 140 STGGEYSGAMVYIAESSPDKKRG----ILGSGLEIGtlsGYIAASVIVTIltllltdeqMLSWGWRIPFLIAAPIGLV-G 214
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGlamgIRQTGVPLG---GALAAALLPPL---------ALHYGWRAAFVVAGLVSILaA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 215 LYLRRHLDESPIFeemeKAQEESEDNEQFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLL 294
Cdd:cd17475 165 VLFWLFYREPPAA----SAATESASTLLRSLKEVLRN--RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 295 IISITMALMIPLALYFGKLSDKI--GNKRVVQIGLLGLTVFAIPAFLLIGNG-HIAAIFAGIFVLGFFLSVYEGTLPSLL 371
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGtPLWLLVLLLILLGLFAIGWNGLYLTLV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447109680 372 PSLffTDVRYRALSISFNISVSIFG-GTTPLVCSYLVHATGNPLAPAFYLAGVSIIGLVVFS 432
Cdd:cd17475 319 AES--AGPEQAGTALGLANTINFIGiAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
246-446 |
7.56e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 7.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 246 MDILKYHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQI 325
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 326 GLLGLTVFAIPAFLLignGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFftDVRYRALSISFNISVSIFGGTT-PLVCS 404
Cdd:COG2814 81 GLLLFALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLV--PPERRGRALGLLGAGLGLGPALgPLLGG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 447109680 405 YLVHATGnpLAPAFYLAGVSIIGLVVFSVLFVTTSGRALKGS 446
Cdd:COG2814 156 LLADLFG--WRWVFLVNAVLALLALLLLLRLLPESRPAARAR 195
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
87-443 |
8.72e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 57.36 E-value: 8.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 87 GRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGS 166
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 167 ----GLEIGTLSGYIAASVIVTiltllltdeqmLSWGWRIPFLIAAPIGLV---GLYLrrhLDESPIFEemekaqeesed 239
Cdd:cd17362 132 lkelFIVLGILLGYVSGYAFAD-----------VVGGWRYMYGLAAPPALLlgiGMWF---LPPSPRWQ----------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 240 neqfsfmdilKYHKKDFLLSTVIVAFFNITNY-MILSYIPSYLTQV---LKVKETTGLLIISITMALMIPLALYfgkLSD 315
Cdd:cd17362 187 ----------GNYRKPLIIGLGLVLFQQITGQpSVLYYAATIFKSAgfsAASDATLVSVGLGVFKLLMTIVAVL---LVD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 316 KIGNKRVVQIGLLGLTV--FAIPAFLL-IGNGHIAAIFAGIFVLGFFLSVYE---GTLPSLLPS-LFFTDVRYRALSisf 388
Cdd:cd17362 254 KLGRRPLLLGGVSGMVVslFLLAAYNLfVQMGPAGLAWLSLVALLLYVGAYQisfGPISWLMVSeIFPLRVRGRAIA--- 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 447109680 389 nISVSIFGGTTPLVCSYLVHATGNPLAPAFYL--AGVSIIGLVVFSVLFVTTSGRAL 443
Cdd:cd17362 331 -LAVLVNFGSNALVSLAFLPLQELIGLPGTFLgfGVIGVLALLFIYFTVPETKGLSL 386
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-431 |
9.06e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.18 E-value: 9.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 25 AVVATGIGNAMewfdfgLYAYLAVILSQlffSGVDNSGLQLVLTFatFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTII 104
Cdd:cd17477 4 SVALLGLGSGL------LLPLLSLRLER---EGVSTALIGLVASA--YYLGIL---LGSPLVPRLIRRVGHIRAFAAGAA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 105 LMALSTLFIALLPTyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVT 184
Cdd:cd17477 70 ITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 185 ILTLLltdeqmlswGWRiPFLIAAPI---GLVGLYLRRHldespifeemekAQEESEDNEQFSFMDILKYHKkdflLSTV 261
Cdd:cd17477 142 LVGTA---------GAL-PFLIAAVLlllALVPLLLTRR------------AAPEIEEAESISLRRLLRIAP----LALL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 262 IVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIpLALYFGKLSDKIGnKRVVQIGLLGLTVFAIPAFLLI 341
Cdd:cd17477 196 GAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLL-LQWPLGWLADRFD-RRRVLLGCALLGALAALLLPLV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 342 GNGHIAAIFAGIFVLGFFLSVYegTLPSLLPSLFFTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGnPLAPAFYLA 421
Cdd:cd17477 274 PGLPLALLVLLFLWGGAAGPLY--TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG-PHGLFLFLA 350
|
410
....*....|
gi 447109680 422 GVSIIGLVVF 431
Cdd:cd17477 351 AVALLFLLFL 360
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
24-245 |
9.52e-09 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 57.43 E-value: 9.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 24 KAVVATGIGNAMEWFDFGLYAYLAVILSQLFF--SGVDNSGLQLVLTfatfAVAFLVRPIGGVFFGRIGDKYGRKIVLST 101
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYhgKGPLPSSVSAAVN----GSASIGTLAGQLFFGWLADKLGRKRVYGM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 102 TIILMALSTLFIALLPTYEQIGVWApiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGL----EIGTLSGYI 177
Cdd:TIGR00887 92 ELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVfamqGFGILAGAI 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447109680 178 AASVIVTILTLLLTDEQMLS-----------WGWRIPFLIAAPIGLVGLYLRRHLDESPIFEEMEKAQEESEDNEQFSF 245
Cdd:TIGR00887 170 VALIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDVEQAASDMSAV 248
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
81-359 |
2.21e-08 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 56.10 E-value: 2.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWAPILLLVARMIQGFstGGEYSGAMvyIAESSPDKK 160
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQGM--GWPPSGRT--MVHWFSKKE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSGLEIG-TLSGYIAASVIVTILTLLLTDEQMLSWGwrIPFLIAAPIGLVGLYLRRHLDES----PI---FEEMEK 232
Cdd:cd17345 129 RGTWTSIWNIShNVGGGLVGPLAGLGLAIFGDGWWRGAFI--FPAIIAIIVAVIVLFLGKDTPESeglpPIeeyKGDYPE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 233 AQEESEDNEQFSFMDIL-KYHKKDFLLstVIVAFFNITNYM----ILSYIPSYLTQVLKVKETTGLLIISITMALMIPLA 307
Cdd:cd17345 207 EADGEEEEQELSAWEIFvKYVLKNKLL--WYIAIANVFVYLvrygILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGT 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 447109680 308 LYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFF 359
Cdd:cd17345 285 LLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFL 336
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
37-355 |
3.67e-08 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 55.54 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 37 WFDFGLYAYLAVILSQLF---FSGVDNSGLQ--------LVLTFATFAVAfLVRPIggvfFGRIGDKYGRKIVLstTIIL 105
Cdd:COG2270 17 LYDWANSAFSTVITTFVFppyFTSVAALGDPaaatalwgYALAIAGLLVA-LLAPV----LGAIADRSGRKKPF--LAFF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 106 MALSTLFIALLPTYEQIGVWAPILLLVARMIQgfstggeYSGAMV----YIAESSPDKKRGILgSGleIGTLSGYIAASV 181
Cdd:COG2270 90 TLLGVLATAALFFVAPGGLWLGLLLFVLANIG-------FEGSLVfynaFLPDIATPEEIGRV-SG--LGWALGYLGGVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 182 IVTILTLLLTDEQML-----SWGWRIPFLIAA-PIGLVGLYLRRHLDESPIFEEMEKAQEESEDNEQF--SFMDILKYHK 253
Cdd:COG2270 160 LLLINLALFLKPEAFglpdaGEAVRISFLLTAlWWLLFALPLFLFLPERPRPGPAPPRGAVRAGFRELrrTLRELRRYRD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 254 -KDFLLSTvivAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTV 332
Cdd:COG2270 240 lLRFLLAY---FFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIV 316
|
330 340
....*....|....*....|....*
gi 447109680 333 FAIPAFLLIGNGH--IAAIFAGIFV 355
Cdd:COG2270 317 VCLAAYFLTTALAfwILGLLIGLVM 341
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-215 |
1.10e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.76 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 23 RKAVVATGIGNAMEWFDF-GLYAYLAVILSQLFFSGVDNSGLQLVLTFATFAVaflvrpiGGVFFGRIGDKYGRKIVLST 101
Cdd:cd17316 176 RRRTLLLILLWFFISFGYyGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALV-------GALIAGLLSDRIGRKKTLVI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 102 TIILMALSTLFIALLPTYEqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRgilGSGLEIGTLSGYIAASV 181
Cdd:cd17316 249 GLILSGILALPLFYLLSGS------PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR---ATGVGLSYNLGRLGGGG 319
|
170 180 190
....*....|....*....|....*....|....
gi 447109680 182 IVTILTLLLTdeqmLSWGWRIPFLIAAPIGLVGL 215
Cdd:cd17316 320 APPLIALLLA----STGGTGVPALILALLAIVAL 349
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
67-176 |
1.15e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 54.25 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 67 LTFATFAVAFLVrpiGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQIGVWapilllvaRMIQGFSTGGEYS 146
Cdd:TIGR00898 131 LTQSCFFVGVLL---GSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--------RLLVGMGIGGIWV 199
|
90 100 110
....*....|....*....|....*....|
gi 447109680 147 GAMVYIAESSPDKKRGIlgsgleIGTLSGY 176
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAI------VGTLIQV 223
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
251-362 |
1.43e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 53.32 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 251 YHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGL 330
Cdd:cd17471 196 PVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAG 275
|
90 100 110
....*....|....*....|....*....|..
gi 447109680 331 TVFAIpafLLIGNGHIAAIFAGIFVLGFFLSV 362
Cdd:cd17471 276 VLFYL---GLALATSLWQLIALQLLNAIFIGI 304
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-213 |
1.79e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 50.34 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 69 FATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGA 148
Cdd:TIGR00880 4 LAGYALGQL---IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447109680 149 MVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILTLlltdeqmlSWGWRIPFLIAAPIGLV 213
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQ--------FLGWRAPFLFLAILALA 129
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
55-357 |
1.87e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.97 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 55 FSGVDNSGLQLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVAR 134
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQF---LASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL--------WLLFLAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 135 MIQGFsTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILTLLLtdeqmlswgwriPFLIAAPI 210
Cdd:cd17330 95 FLDGL-TGGNVSVAQAYIADITDEEERakafGIISAAFGLGFILGPALGGFLSTPYGYAL------------PFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 211 GLVGLYLRRHldespifeemekaqeesedneqfsfmdILKYhkkdFLLSTVIVAFFNITNYMILSYIPSYLTQVLK-VKE 289
Cdd:cd17330 162 ALLNLVLVLF---------------------------FLPP----LRRLLLVYFLIALAFAGLESVFSLFLKDRFGfSPS 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447109680 290 TTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLgltvFAIPAFLLIG---NGHIAAIFAGIFVLG 357
Cdd:cd17330 211 QIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLL----LAIIGLLLLPfasSVPLLVLAAAILAFG 277
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-380 |
2.02e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 53.04 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 82 GGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR 161
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 162 G----ILGSGLEIGtlsGYIAAsvivtILTLLLTDEQmlswGWRIPFLI--AAPIGLVGLyLRRHLDESPIFEEMEKAQE 235
Cdd:PRK11551 138 GtavsLMYCGVPFG---GALAS-----VIGVLAAGDA----AWRHIFYVggVGPLLLVPL-LMRWLPESRAFAQAAGAGK 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 236 ESEdneqfSFMDILkyHKKDFLLSTVI--VAFFN--ITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPlALYFG 311
Cdd:PRK11551 205 QRA-----PVLRAL--FGEGRATATLLlwISYFFtlIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALG-SLLIG 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447109680 312 KLSDKIGNKRVVQIGLLGLtVFAIPAflLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVR 380
Cdd:PRK11551 277 ALMDRLRPRRVVLLIYAGI-LASLAA--LAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVR 342
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
161-372 |
2.28e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 52.99 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSGLEIGTLSGYIAASVIVTILTLLLTDEQMlSWGWRIPFLIAAPIGLVGLYLRrhldespIFEEMEKAQEESEDN 240
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNA-SRGYFLTALIIGIIGIILLLIC-------FFGTRERVVPPEEEK 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 241 EQFSFMDILKY--HKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALyFGKLSDKIG 318
Cdd:cd17332 206 SKLPLLKSLKAllKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLP-WPPLKKRFG 284
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 447109680 319 NKRVVQIGLLgLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLP 372
Cdd:cd17332 285 KKKAFFIGLL-LAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLA 337
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
58-430 |
2.32e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 2.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 58 VDNSGLQLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALlptyeqigVWAPILLLVARMIQ 137
Cdd:cd17329 27 HQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF--------AHSPWLFAIALVLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 138 GFSTGGEYSGAMVYIAESSPDKKRG----ILGSGLEIGTLSGYIAASVIVTIltllltdeqmlswGWRIPFLIAAP---I 210
Cdd:cd17329 99 GFGGGLFEPASEAMIADVTTPENRTrafsLLYWAINLGVAIGPLLGGLLLLY-------------SFRLLFLAAAVlflL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 211 GLVGLYLRRHldespifEEMEKAQEESEDNEQFSFMDILKYhkKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLK--VK 288
Cdd:cd17329 166 AALVLLFLLP-------ETRPKRRAAEKTEILRGYKIVLRD--RAFLLFLLASFLISLIYFQLESTLPVYVVEILGlgES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 289 ETTGLLIIS--ITMALMIPLALYFGKlsdkignKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGT 366
Cdd:cd17329 237 LLGLLLALNalLIVLLQFPVARLVER-------FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447109680 367 LPSLLPSLffTDVRYRALSISFNISVSIFGGTTPLVCSYLVHATGNPLAPAFYLAGVSIIGLVV 430
Cdd:cd17329 310 VQTLVAAL--APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
20-215 |
3.24e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.17 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 20 KQARKAVVATGIGNAMEwfdFGLYAYLAVILSQLFFsgvdNSGLQLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVL 99
Cdd:cd17324 198 PRLRLAYLITFLLFGGF---FALYTYLAPFLTDVPG----FSSSAIIGLLLLFGVAGV---VGSPLAGRLADRGGRRALL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 100 STTIILMALSTLFIALLPTyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDkKRGILGSgleIGTLSGYIAA 179
Cdd:cd17324 268 IALLLLAAALLLLTLLGPS--------PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASS---LYLAAYNLGG 335
|
170 180 190
....*....|....*....|....*....|....*.
gi 447109680 180 SVIVTILTLLLTdeqmlSWGWRIPFLIAAPIGLVGL 215
Cdd:cd17324 336 ALGAALGGLVLD-----HGGWAGVGWVGAALLLLAL 366
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-431 |
3.40e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.32 E-value: 3.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 64 QLVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALsTLFIALLPtyeqigvWAPILLLVARMIQGFSTGG 143
Cdd:cd17333 32 DVSVIFSSQNAGYL---IGSLLAGFLMKRLGRRRTLILGLLLISL-ALALIFAT-------PSIYLFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 144 EYSGAMVYIAESSPdKKRGILGSGLEigTLSGyIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVGLYLRrhlde 223
Cdd:cd17333 101 LDTGANTFVGALFE-ESSATRLNVLH--GFFG-LGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTL----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 224 spiFEEMEKAQEESEDNEQFSfMDILKYHKKDFLLSTVIVAFFNI-TNYMILSYIPSYLTQVLKVKETTGLLIISITMAL 302
Cdd:cd17333 172 ---FPELPSARNPQQSVGAFS-ASASRLLRNPSIILGALALFLYVgAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 303 MIPLALYFGKLSDKIGNKRVVQIGLLGLTVFaipAFLLIGNGHIAAIFAGIFVLGFFLSvyeGTLPSLLpSLFFTDVRYR 382
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLVLSGSGALLG---LLILLLAPTLVVGLVATALLGLFMA---ALFPTIL-SLGISNLPYA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 447109680 383 ALS-ISFNISVSIFGG-TTPLVCSYLVHATGNPLAPAFYLA-GVSIIGLVVF 431
Cdd:cd17333 321 KGKgTSVLLAAGSIGGaIIPFIMGFIAEAVGIQTAMLLITIlYAIIFVLALL 372
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-217 |
5.90e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.40 E-value: 5.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 37 WFDFGLYAYLAVILSQLFFSgvdNSGLQLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALL 116
Cdd:cd17478 209 WVLSSLTTFLPFYLVQRGYS---LVFAGLLLSLFLFAGA-----IGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 117 PtyeqiGVWAPILLLVArmiqGFSTGGEYSGAMVYIAESSPDKKRgiLGSGLEIGTlsGYIAASVIVTILTLLltdeqML 196
Cdd:cd17478 281 P-----GIWSYILLVLA----GFLLFASFPVTVVLAQELLPGNVG--LASGLMMGL--SFGLGGIGAPVLGAL-----AD 342
|
170 180
....*....|....*....|.
gi 447109680 197 SWGWRIPFLIAAPIGLVGLYL 217
Cdd:cd17478 343 AFGLESVLLILALLPLLGALL 363
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
81-443 |
9.26e-07 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 51.10 E-value: 9.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRK-IVLSTTIILMALSTLFIAllptyeQIGVWApiLLLVARMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17356 60 FGALISSFLSDRIGRKkSIQIGCVIYIIGAIIQVA------AIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKH 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 160 KRGILGSGLEIGTLSGYIAASVIVTILTLLLTDEQmlswgWRIPF---LIAAPIGLVGLYLrrhLDESPifeemekaqee 236
Cdd:cd17356 132 IRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLglqIVWGLLLLIGMFF---LPESP----------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 237 sedneqfsfmdilKYHKKDFLLstVIVAFFNITNYMilSYIPSYLTQVLK---VKETTGLL---IISITMALMIPLALYF 310
Cdd:cd17356 193 -------------RWLYRTILG--IMLQLFQQLTGI--NYFFYYGTTIFQstgLTGSSPLLtsiILYIVNFVSTIPGLFF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 311 gklSDKIGNKRVVQIGLLG-----LTVFAIPAFLLIGNGHI--------AAIFAGIFVLGFFLSVYEGTLPSLLPSLFFt 377
Cdd:cd17356 256 ---VDKFGRRTCLLIGAAGmsiclFIYAAVGVRYLIPNPQSgtsnksagNGMIVFICLFIFSFATTWGPIAWVYVAEVF- 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447109680 378 DVRYRALSISFNISVSIFGGTtplVCSYLVHATGNPLAPAFYL--AGVSIIGLVVFSVLFVTTSGRAL 443
Cdd:cd17356 332 PLRVRSKGMALATAFNWLWNF---LISFFTPFIIGSIGFKYYYifAGCNLLAFIVVFFFVPETKGLTL 396
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
66-215 |
1.48e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 50.33 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 66 VLTFATFAVAFLVRPIggvfFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigVWapiLLLVARMIQGFsTGGEY 145
Cdd:cd17388 42 VLLALYALMQFIFAPI----LGALSDRFGRRPVLLLSLAGAALDYLLMAFAPT-----LW---WLYLGRIIAGI-TGATG 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447109680 146 SGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTIltllltdeqmlswGWRIPFLIAApiGLVGL 215
Cdd:cd17388 109 AVAAAYIADVTPPEQRarnfGLLGAAFGLGFIAGPALGGLLGEI-------------SPRAPFLVAA--GLNGL 167
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
64-359 |
2.98e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.30 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 64 QLVLTFATFAVAFlvrPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPtyeqiGVWApilLLVARMIQGFSTGG 143
Cdd:TIGR00881 31 DLGLLLSSFSIAY---GISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-----SLWV---MAALWALNGIFQGM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 144 EYSGAMVYIAESSPDKKRGILGSGLEIG-TLSGYIAASVIVTILtllltdEQMLSWGWR--IPFLIAAPIGLVGLYLRR- 219
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWNCShNVGGGLLPPLVLFGI------AELYSWHWVfiVPGIIAIIVSLICFLLLRd 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 220 --------HLDESPIfEEMEKAQEESEDNEQF--SFMDILKYHKKDFLLSTVIVAFFnITNYMILSYIPSYLTQVLKVKE 289
Cdd:TIGR00881 174 spqscglpPAEEMPN-EEPDGDAEKKEEELTKkqIFLQYVLLNKVLWYISLGYVFVY-VVRTGILDWSPLYLTQEKGFSK 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447109680 290 TTGLLIISITMALMIPLALYFGKLSDKI--GNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFF 359
Cdd:TIGR00881 252 EKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFL 323
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
74-381 |
3.47e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 49.11 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 74 VAFLVRPIGGVFFGRIGdkYGRKIVLSTtiILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIA 153
Cdd:cd17384 43 VQLITNPIVGPLTNRIG--YSLPMFVGF--VIMFISTLLFAFGESY--------GVLFLARALQGVGSACSSVAGMGMLA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 154 ESSPDKKR-----GILGSGLEIGTLSGYIAASVIVTILtllltdeqmlswGWRIPFLIAAPIGLVGLYLRRHldespiFE 228
Cdd:cd17384 111 SLYPDDKErgkamGIALGGLALGVLVGPPFGGVMYEFV------------GKSAPFLILAFLALLDGALQLF------IL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 229 EMEKAQEESEdnEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKE-TTGLLIISITMALMIPLA 307
Cdd:cd17384 173 QPSVKSEESE--EGTPWKTLLK--DPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKwQLGTAFLPDSIGYLIGTN 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447109680 308 LyFGKLSDKIGNKRVVQIGLL--GLTVFAIPAflligNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLffTDVRY 381
Cdd:cd17384 249 L-FGPLAHKIGRWLCSLLGMLlvGISLILIPL-----AKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYL--VDLRH 316
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
61-233 |
3.50e-06 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 49.19 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 61 SGLQLVLTFATFAVAFlvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFS 140
Cdd:cd17360 34 TGWQELIVSSTVAGAA----VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEV--------LIVGRVLVGLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 141 TGGEYSGAMVYIAESSPDKKRGILgsgleigtlsgyiaasviVTILTLLLTDEQMLSW-----------GWRIPFLIAAP 209
Cdd:cd17360 102 VGIASMTVPLYIAEAAPPRIRGRL------------------VTINVLFITGGQFVAYvingafsylpgGWRWMLGLAAV 163
|
170 180
....*....|....*....|....
gi 447109680 210 IGLVGLYLRRHLDESPIFEEMEKA 233
Cdd:cd17360 164 PAVLQFIGLLFLPESPRWPSTRRA 187
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
87-434 |
4.50e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.77 E-value: 4.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 87 GRIGDKYGRKIVLSTTIILMALSTLFIallPTYEQIGVWApilLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILG- 165
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTLLT---PLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTs 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 166 ---SGLEIGTLSGYIAASVIVTiltllltdeqmlSWGWRIPFLIAAPIGLVGlylrrhldeSPIFeemekaqeesedneq 242
Cdd:cd17318 151 iaySGSQFGTVIAMPLSGFLCE------------SLGWPSIFYIFGGLGLLW---------CLLW--------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 243 fsfmdilkyhkkdFLLS----TVIVAFF--NITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDK 316
Cdd:cd17318 195 -------------FFLVlpvwAIVVAHFghNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADW 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 317 IGNKRVVQ----------IGLLGLTVFAIPA------------FLLIGNGHIAAIFAGIFVLGFFLS-VYEGTLpsllps 373
Cdd:cd17318 262 LRSRGILStttvrklftsIGFLGPGVFLIALgylgsnatlavvFLTLSVGLSGACYSGFLVNHLDLApNYAGTL------ 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447109680 374 lfftdvryraLSISFNISvSIFGGTTPLVCSYLVHATGNPLA--PAFYL-AGVSIIGLVVFSVL 434
Cdd:cd17318 336 ----------MGITNTAA-TIAGIISPLIVGAIVKNDQTIGQwrIVFFIsAAIYILGAIFYLIF 388
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
84-431 |
5.67e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 84 VFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR-- 161
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY------SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERsr 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 162 --GILGSGLEIGTLSGYIAASVIvtiltllltdeqMLSWGWRIPFLIAAPIGLVGLYLRRHLdESPIFeemekaqeesed 239
Cdd:cd17380 126 avSIVTAGSYLGTLLGGLIGPLL------------LEYYGWPSVFYFFGLLGLLWALVWLIY-LPPVW------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 240 neqfsfmdilkyhkkdfllsTVIVAFF--NITNYMILSYIPSYLTQVLkVKETTGLLIISITMALMIPLALYFGKLSDKI 317
Cdd:cd17380 181 --------------------AIIVAHFcmNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 318 GNKRV---------VQIGLLGltvfaiPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSlfFTDVRYRALSISF 388
Cdd:cd17380 240 ISRGWtvtsvrklmQSIGFLG------PALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVN--HQDIAPNYAGIVF 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 447109680 389 NISVSIfgGTTP-----LVCSYLVHATGNpLAPAFYL-AGVSIIGLVVF 431
Cdd:cd17380 312 GISNTA--GTIPgivgvYLTGYILEATGS-WSLVFVLaAVVNLVGAVVF 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
263-436 |
6.80e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.19 E-value: 6.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 263 VAFFNITNYMILSYIPSYLTQVLKVK---ETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVqigLLGLTVFAIPAFL 339
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFglsASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVL---LLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 340 LIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGNPLAPAFY 419
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFL 156
|
170
....*....|....*..
gi 447109680 420 LAGVSIIGLVVFSVLFV 436
Cdd:cd06174 157 IAAALALLAAILLLLVV 173
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
75-227 |
6.95e-06 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 48.26 E-value: 6.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 75 AFLVRPIGGVFFgrigDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAE 154
Cdd:cd17435 49 ALLASLTGGVLI----DRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAE 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447109680 155 SSPDKKRGILGSGLE----IGTLSGYIAASVIVTIltllltdeqmlSWGWRIPFLIAAPIGLVGLYLRRHLDESPIF 227
Cdd:cd17435 117 IAPQHRRGLLVSLNElmivIGILLAYISNYAFANV-----------SNGWKYMFGLVIPLAALQAIAMYFLPPSPRF 182
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
44-374 |
2.33e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 46.34 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 44 AYLAVILSQLFFSGVDNSglqLVLTFATFAVAflvrpIGGVFFGRIGDKYG-RKIVLSTTIILMALSTLFIALLptyeqI 122
Cdd:cd17337 18 GFLSPYLVDLGFSEAQAA---LLFTVYGLTVA-----IASWLSGVLAELFGpRRVMLIGLIIWLVFEVLFLAFG-----L 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 123 GVWAPILLLVARMIQGFStggeYS----GAMVYIAESSPDKKRGILGS------GLEIGTLSGYIAAS---VIVTILTLL 189
Cdd:cd17337 85 PSHNYPLMLLTYGLRGFG----YPlfaySFLVWITYRTPAERLGSAVGwfwfafTGGLPVLGSYLASFtipVIGEIGTLW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 190 LtdeqmlSWGWripfliAAPIGLVGLYLRRHldespIFEEMEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNIT 269
Cdd:cd17337 161 L------SLVF------VALGGLIALFLVRD-----RTGEQPLANPSEEPLKELLSGITILFRNPKIAIGGIVRIINTLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 270 NYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQI------GLLGLTVFAIPafLLIGN 343
Cdd:cd17337 224 QFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWfggvgcAISTLLFYYVP--QLFGH 301
|
330 340 350
....*....|....*....|....*....|.
gi 447109680 344 GHIAAIFAGIFvLGFFLSVYeGTLPSLLPSL 374
Cdd:cd17337 302 NYWAALIAAIL-FGIGLAGF-VPLSALMPSL 330
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
59-377 |
3.19e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 46.09 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 59 DNSGLQLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIvlstTIILMALSTLFIALLptyeqiGVWAPIL--LLVARMI 136
Cdd:cd17361 49 DDQLLQLFTSSLYLAGL-----VASLLASYVTRKWGRKP----SMLIGGVLFLVGAAL------NAAAQNIamLIVGRIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIvTILTllltdEQMLSWGWRIPFLIAAPIGLVGLY 216
Cdd:cd17361 114 LGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLI-NYGT-----SKIKPNGWRLSLGLAAVPALILLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 217 LRRHLDESPIFEEMekaqeesedneqfsfmdilkyhkkdfLLSTVIVAFFNIT-NYMILSYIPSyLTQVLKVKETTGLLI 295
Cdd:cd17361 188 GSLFLPETPNSPQL--------------------------VIAILIPFFQQLTgINVIMFYAPV-LFQTLGFGSDASLIS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 296 ISITMALMIPLALYFGKLSDKIGNKRV------------VQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVy 363
Cdd:cd17361 241 AVITGAVNVVSTLVSIYLVDRFGRRFLlleggvqmlasqVAIGILLAVKFGDGGELPKAYAIAVVVLICLYVAAFAWSW- 319
|
330
....*....|....
gi 447109680 364 eGTLPSLLPSLFFT 377
Cdd:cd17361 320 -GPLGWLVPSEIFP 332
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
162-359 |
3.20e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.84 E-value: 3.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 162 GILGSGLEIGTLSGYIAASVIVTILtLLLTDEQMLSWGWRIPFLIAApIGLVGLYLRRHLDESPifeemEKAQEESEDNE 241
Cdd:PRK08633 142 GLLEAFTIVAILAGTALFSFLFESV-NGNTPSEILGRIAPAGLVLLA-VAVLGLIFAYRLPKVP-----AAAPEVFDKKK 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 242 QFSFMDILK-----YHKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPL-ALYFGKLSD 315
Cdd:PRK08633 215 YLFPKLLWRnlkllRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIGIgSLLAGRLSG 294
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 447109680 316 KIGNKRVVQIGLLGLTVFAipaFLLIGNGHIAAIFAGIFVLGFF 359
Cdd:PRK08633 295 RHIELGLVPLGALGLALSL---FLLPTAPSLASVLVLFFLFGFS 335
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
71-430 |
6.84e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.91 E-value: 6.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 71 TFAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwaPILLLVARMIQGFSTGGEYSGAMV 150
Cdd:cd17353 43 AFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL-------PLLFLGYGVLGGIGAGIGYITPVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 151 YIAESSPDkKRGiLGSGLEIG--TLSGYIAASVIVTILTLLLTDEQMLSWGwrIPFLIAAPIGlvGLYLRRHLDESPIFE 228
Cdd:cd17353 116 TAVKWFPD-KRG-LATGIVIAgfGLGSLIFSPLIAYLINTVGVPTTFLILG--IIFLIIIVIG--AFLIRDPPKGWVPPG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 229 EMEKAQEESEDNEQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLAL 308
Cdd:cd17353 190 VDPLANNAENSPRDYTPREMLR--TPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRP 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 309 YFGKLSDKIGNKRVVQIGLLGLTVFaipAFLLIGNGHIAAIF-AGIFVLGFFLSVYEGTLPSLLPSLFFTD---VRYRAL 384
Cdd:cd17353 268 FWGWLSDKIGRKNTLSIAFLIQGVA---MFLLPFIGSVAVLFvLGVALIGFCYGGGFALFPALTADFFGTKnagTNYGLL 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 447109680 385 SISFNISvSIFGgttPLVCSYLVHATGnpLAPAFYLAGV-SIIGLVV 430
Cdd:cd17353 345 YTAKGVG-GLIG---PIIAAYVLYTGG--YNAAFIIAAAlSLVALAL 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-218 |
7.37e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 7.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 19 PKQARKAVVATGIGNAME----WFDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFAT--------FAVAFLVRPIGGVFF 86
Cdd:cd17473 174 PEPARKSKSAASPGAATAaalpWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGsaaliglaLAIASLAGAIGALLF 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 87 GRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGS 166
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFALMALGFLLLALASGL--------WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 447109680 167 GLEIGTLSGYIAASVIVTILTLLLTDEQMLswgWRIPFLIAAPIGLVGLYLR 218
Cdd:cd17473 326 IVTSAFFLGQFLSPLVLGPLVNLTGGLSGA---FLILGVLALVLAIVLLLLR 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-215 |
8.09e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 8.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 19 PKQARKAVVATGIgNAMEWFDFGLYAYLAvilSQLFFSgvdnsglqLVLTFATFAVAFLVRPIGGVFFGRIGDKYGRKIV 98
Cdd:cd17370 199 PKAFWLYLLAVAL-FALGNFSFAFLILRA---QELGLS--------AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 99 LSTTIILMALSTLFIALLPtyeqigvwAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLS 174
Cdd:cd17370 267 LILGYLSLALAYLGFALGS--------SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRgtayGLFNTVVGIGWLL 338
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 447109680 175 GYIAASVIVTiltllltdeqmlSWGWRIPFLIAAPIGLVGL 215
Cdd:cd17370 339 ASLIAGYLWD------------LISPSAAFLFSAVLALIAL 367
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
81-357 |
1.74e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 43.96 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKivlSTTIILMALSTLFIALLPTYEQIGVwapILLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:TIGR00894 91 IIQIPVGYLAGKYVFK---WSIGIGMFLSSVISIVIPWAAGGGI---ALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKE 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSgleiGTLSGYIAASVIVTILTLLLTDEQMlswGWRIPFLIAAPIGLVGLYL---------RRHLDESpIFEEM- 230
Cdd:TIGR00894 165 RSRLLG----MSTSGFQLGTFIFLPISGWLCESWG---GWPMIFYVFGIVGCAWSLLwfvfpaddpSIHPCIS-KFEKKy 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 231 --EKAQEESEDNEQ-FSFMDILKYhKKDFLLSTVIVAFFNITNYMILsYIPSYLTQVLKVKETTGLLIISITMALMIPLA 307
Cdd:TIGR00894 237 inSSLQGQKGSTRQsLPIKAIPKS-LPVWAIWFAIFGHFWLYTILPT-YLPTFISWVLRVSGKENGLLSSLPYLFAWLCS 314
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447109680 308 LYFGKLSD-KIGNKRVVQ---------IGLLGLTVFAIPA------------FLLIGNGHIAAIFAGIFVLG 357
Cdd:TIGR00894 315 IFAGYLADfLKSSKTLSLtaarkifngIGGLGPGIFAYALpylsaafyltiiILTLANAVSSGPLAGVLINS 386
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
81-360 |
1.88e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17312 53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSL--------WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RG----ILGSGLEIGTLSGYIAASVIVtiltllltdeqmLSWGWRIPFLIAAPIGLVG-LYLRRHLDESPIFEemekaqe 235
Cdd:cd17312 125 RGtvygIWSTSHNFGGILAPILAASLA------------SYYGWRAAFLVPGIVGLVVaIILFFFLRDSPPYV------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 236 esedneqfsfmdilkyhkkdFLLSTVIvAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSD 315
Cdd:cd17312 186 --------------------WVLSLAY-AFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 447109680 316 KI--GNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGiFVLGFFL 360
Cdd:cd17312 245 KLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLL-FLIGFFV 290
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
57-215 |
3.00e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.97 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSGLqlvlTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvwaPILLLVARMI 136
Cdd:cd17489 225 GISNAGL----FFTVYAIALL---LSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS--------PWMLLLAAVL 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447109680 137 QGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILtllltdeqMLSWGWRIPFLIAAPIGLVGL 215
Cdd:cd17489 290 YGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV--------AELFGYRAMFLLAAVVVLLAL 360
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
81-411 |
3.88e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAM--------LIILRFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 161 RGILGSGLEIGTLSGYIAASVIVTILTllltdeqmLSWGWRIPFLIAAPIGLVGLYLrrhldespifeemekaqeesedn 240
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPIIGGFIT--------QSLGWRWIFWFLAIISGFCLIL----------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 241 eQFSFMDILkyhkkdfLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKE-TTGLLIISITMALMIpLALYFGKLSDKIGN 319
Cdd:cd17323 170 -IFLFLPIV-------LLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPgEVGLMYLPIGIGALI-GSIIGGRLSDYYYR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 320 KRVVQIG----------LLGLTVFAIPAFLLI------GNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFftdVRYRA 383
Cdd:cd17323 241 RLKKKNGgkpepearlpPAFIGAFLFPIGLFIfgwtiyPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSY---PKYAA 317
|
330 340
....*....|....*....|....*....
gi 447109680 384 LSIS-FNISVSIFGGTTPLVCSYLVHATG 411
Cdd:cd17323 318 SALAaNTLVRSIFAAIFPLFAQPMFNNLG 346
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
81-165 |
4.15e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 42.35 E-value: 4.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGD-KYGRKIVLSTTIILMALSTLFIALLPTYeqigvWAPILLlvaRMIQGFSTGGEYSGAMVYIAESSPDK 159
Cdd:cd17378 48 IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY-----WVYAFL---RFLTGFGRSGIGTCALVLATEPVGPK 119
|
....*.
gi 447109680 160 KRGILG 165
Cdd:cd17378 120 WRGQVG 125
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
81-178 |
4.85e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 42.39 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 81 IGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEqigvwapiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKK 160
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100
....*....|....*....|..
gi 447109680 161 RGILGSGLEI----GTLSGYIA 178
Cdd:cd17437 119 RGFLTSFPEIfiniGILLGYVS 140
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
257-443 |
5.63e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 257 LLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIP 336
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 337 AFLLIGnghIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFftDVRYRALSISFNISVSIFGGTT-PLVCSYLVHATGNPLa 415
Cdd:COG0477 96 CGLAPS---PELLIAARALQGIGAGGLMPGALALIAELF--PARERGRALGLWGAAIGLGLALgPLLGGLLVAALGWRW- 169
|
170 180
....*....|....*....|....*...
gi 447109680 416 pAFYLAGVSIIGLVVFSVLFVTTSGRAL 443
Cdd:COG0477 170 -IFLINAPLGLLALVLRLRLPESRGLLL 196
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
65-165 |
6.62e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 41.95 E-value: 6.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 65 LVLTFATFAVAFLvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYeqigvwapILLLVARMIQGFSTGGE 144
Cdd:cd17379 35 LDLFQSSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGG 103
|
90 100
....*....|....*....|.
gi 447109680 145 YSGAMVYIAESSPDKKRGILG 165
Cdd:cd17379 104 WMTGYVLVTEFVGSKYRRTVG 124
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
34-143 |
7.54e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 41.69 E-value: 7.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 34 AMEWFDFGLYAYLAVILSQLFFSGVdnsglqlvltfatfavaflvrPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFI 113
Cdd:cd17377 28 VSEWFLVGNAAYKVSLASSFFFAGV---------------------LIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFN 86
|
90 100 110
....*....|....*....|....*....|
gi 447109680 114 ALLPTYEqigvwapiLLLVARMIQGFSTGG 143
Cdd:cd17377 87 ALAPSYE--------FFAVSRFLVGVMNGG 108
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
86-371 |
7.82e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 7.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 86 FGRIGDKYGRKIvlsttIILMALSTLFIALLPTYEQIGVWapiLLLVARMIQGfsTGGEYSGAMVYIAESSPDKKR---- 161
Cdd:cd17472 52 FGLLSDRIGRKP-----VILFGLLLFIAGSLLAAYATSIY---GLILGRALQG--SGAISSVVMALLADLTREENRtkam 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 162 GILGSGLEIGTLSGYIAASVIVTIltllltdeqmlsWGWRIPFLIAAPIGLVGL-YLRRHLDESPIfeemekaQEESEDN 240
Cdd:cd17472 122 ALIGASIGIAFAISMVLGPLLAAH------------LGVSGLFLITAILSLVSLlILLFFVPDPPK-------IVQISEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 241 EQFSFMDILKyhKKDFLLSTVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLL---IISITMALMIPlalyFGKLSDKI 317
Cdd:cd17472 183 EKKKLKKLLK--NKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVylpAILIGFILMVP----FVIYAEKK 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 447109680 318 GnkRVVQIGLLGLTVFAIP-AFLLIGNGHIAAIFAG--IFVLGFFLsvYEGTLPSLL 371
Cdd:cd17472 257 G--KMKQVFVSSILLIAVGfLLLLFAATSLWLLIIGliIFFIGFNL--LEALLPSLV 309
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
56-436 |
8.05e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.63 E-value: 8.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 56 SGVDNSGLQLVLTFATfAVAFLVRPIGGVFFgrigDKYGRKIVLSTTIILMALSTLFIALLPTyeqigvwAPILLLVARM 135
Cdd:cd17314 33 FGYSSSQIATAASLSN-LGMLLTQPILGFIA----DSFGPRPLMALAGIMVLAGYTYLSYVFN-------SFPLSYACFV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 136 IQGFSTGGEYSGAMVYIAESSPDKKrgilgsGLEIG-TLSGYIAASVIVTILTLLLTDEQMLSWGWRIPFLIAAPIGLVG 214
Cdd:cd17314 101 FIGAGTGILYGSAVLVTTQYFPDTK------GLALGlPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 215 LYLrrHLDESPIFEEMEKAQEESEDNEQFSFMDilkyhKKDFLLSTVIVAFFniTNYMILSYIPSYLTQVLKVKETTGLL 294
Cdd:cd17314 175 SLL--GFKEPPDNQARLHVQKKKTQTMGEIFRD-----KVFWILFIAIFLVL--IGGFLFIANMASLVRSLQLDAPSFVT 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 295 IISITMALMIPL-ALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAAIFAGIFVLGFFLSVYEGTLPSLLPS 373
Cdd:cd17314 246 KLMSIYGLFNAFgRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVST 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447109680 374 LFFTDVRYRALSIsFNISVSIFGGTTPLVCSYLVHATGNPLApAFYLAGVsIIGLVVFSVLFV 436
Cdd:cd17314 326 VFGTESFATLYGI-LLFAPAIGSILGPMLGAKFYDRTPSYIS-AVYIYAV-IVFLASAILLAV 385
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
57-140 |
1.25e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.05 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 57 GVDNSGLQLVLTFATFAVAflvrpIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTYEQigvwapilLLVARMI 136
Cdd:PRK11102 22 GVSAGSVQMTLSAYILGFA-----IGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQ--------LIYMRFL 88
|
....
gi 447109680 137 QGFS 140
Cdd:PRK11102 89 HGLA 92
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
72-441 |
1.50e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.06 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 72 FAVAFLVRPIGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTyeqigVWApilLLVARMIQGFsTGGEYSGAMVY 151
Cdd:PRK09874 60 FSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQN-----IWQ---FLILRALLGL-LGGFVPNANAL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 152 IAESSPDKKrgilgSGLEIGTLS-GYIAASVIVTILTLLLTDeqmlSWGWRIPFLIAAPIGLVGLYLrrhldesPIFEEM 230
Cdd:PRK09874 131 IATQVPRNK-----SGWALGTLStGGVSGALLGPLAGGLLAD----SYGLRPVFFITASVLFLCFLV-------TLFCIR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 231 EKAQEESEdNEQFSFMDILKYHKK-----DFLLSTVIVAFFNITNYMILS-YIPSYLTQVLKVKETTGlLIISITMALMI 304
Cdd:PRK09874 195 ENFQPVSK-KEMLHMREVVTSLKNpklvlSLFVTTLIIQVATGSIAPILTlYVRELAGNVSNIAFISG-MIASVPGVAAL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 305 PLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHIAaifagifVLGFFLSVYEGT-LPSLLPSLFFTDVRYRA 383
Cdd:PRK09874 273 LSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLG-------ILRFLLGAADGAlLPAVQTLLVYNSSNQIA 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447109680 384 LSI-SFNISVSIFGGTT-PLVcsylvhatGNPLAPAFYLAGVSII--GLVVFSVLFVTTSGR 441
Cdd:PRK09874 346 GRIfSYNQSFRDIGNVTgPLM--------GAAISANYGFRAVFLVtaGVVLFNAVYSWNSLR 399
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
73-215 |
1.69e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 40.68 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 73 AVAFLVRPIGGVFFGRIGDKYGRKIVLSTT-------IILMALSTLFIALLPTYEQIGVWAPILLLVARMIQGFStggeY 145
Cdd:cd17318 242 SLPYLAMWICSIVGGYLADWLRSRGILSTTtvrklftSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGAC----Y 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 146 SGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAasviVTILTLLLTDEQMLSwGWRIPFLIAAPIGLVGL 215
Cdd:cd17318 318 SGFLVNHLDLAPNYAGTLMGITNTAATIAGIIS----PLIVGAIVKNDQTIG-QWRIVFFISAAIYILGA 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
260-358 |
1.87e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 260 TVIVAFFNITNYMILSYIPSYLTQVLKVKETTGLLIISITMALMIpLALYFGKLSDKIGNKRVVQIGLLgltVFAIPAFL 339
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALL-ARPFAGRLLDRFGRKRLLLIGLL---IFALATLL 77
|
90
....*....|....*....
gi 447109680 340 LIGNGHIAAIFAGIFVLGF 358
Cdd:cd17489 78 YLLATSVALLLVLRLIHGI 96
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
40-217 |
1.97e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 40 FGLYAYLAVILSQLFFSGVDNSGLQLVLTFATFAVAFLVrpiGGVFFGRIGDKYGRKIVLSTTIILMALSTLFIALLPTy 119
Cdd:cd17321 181 GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLV---AAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGA- 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 120 eqigVWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGIlGSGLEIGT--LSGYIAASVIVTILTLLLTDEQMLS 197
Cdd:cd17321 257 ----DSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGA-ASGILNTArqLGGALGVALLGALLTAGLSANLGDS 331
|
170 180 190
....*....|....*....|....*....|....
gi 447109680 198 W--------------GWRIPFLIAAPIGLVGLYL 217
Cdd:cd17321 332 GvaallsaaaaafaaGFHLAFLVAAALALLAALL 365
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
73-182 |
2.13e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 40.67 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 73 AVAFLVRPIGGVFFGRIGDKYGRKIVLsttIILMALSTLFiALLPTYEQigvwAPILLLVARMIQGFSTGGEYSGAMVYI 152
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSL---LICMSVNGFF-AFLSSFVQ----GYGLFLFCRLLSGFGIGGAVPTVFSYF 112
|
90 100 110
....*....|....*....|....*....|
gi 447109680 153 AESSPDKKRGILGSGLEIGTLSGYIAASVI 182
Cdd:cd17440 113 AEVLAREKRGEHLSWLCMFWMIGGIYASAM 142
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-136 |
2.14e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 40 FGLYAYLAVILSQLFFsgvDNSGLQLV----LTFATFAVAFLVRPIGGVffgrIGDKYGRKIVLSTTIILMALSTLFIAL 115
Cdd:cd17341 218 FGSFVGFSNVLPTYFK---TRFGLPLVtagiLAALFPLAGALARPAGGW----LSDRFGGRRRLWWLFIVMTIGAALLSL 290
|
90 100
....*....|....*....|.
gi 447109680 116 LPTYEQIGVWAPILLLVARMI 136
Cdd:cd17341 291 SLPTSGTNLVLFLALFVALGL 311
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
73-182 |
2.31e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 40.25 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 73 AVAFLVRPIGGVFFGRIGDKYGRKIVLsttiilMALSTLFIALLPTYEQI-GVWapiLLLVARMIQGFSTGGEYSGAMVY 151
Cdd:cd17433 48 SVVTLGAAAGGVLGGWIVDRAGRKLSL------MLCSVPFIAGFTVITAAqNVW---MLYVGRLLTGLASGVTSLVVPVY 118
|
90 100 110
....*....|....*....|....*....|....*
gi 447109680 152 IAESSPDKKRGILGSGLE----IGTLSGYIAASVI 182
Cdd:cd17433 119 ISEIAHPRVRGTLGSCVQlmvvIGIMGAYLAGLVL 153
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
260-411 |
2.64e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.87 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 260 TVIVAFFNITNYMILS-YIP--SYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIP 336
Cdd:cd17323 1 VFIISFLTFVVTFGSSiYSPalPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447109680 337 AFLLIgngHIAAIFAGIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSIsfnISVSIFGGTT--PLVCSYLVHATG 411
Cdd:cd17323 81 CALAP---NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGV---YSLGPLLGPAlgPIIGGFITQSLG 151
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
38-436 |
3.91e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 38 FDFGLYAYLAVILSQLFFSGVDNSGLQLVLTFATFAVAFLVRPIGgVFFGRIGDkygRKIVLSTTIILMALSTLFIALLP 117
Cdd:cd17490 8 FWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLG-ILSDRIGK---RKLFIIIGLLFTVLASLIMILFP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 118 TyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPD---KKRGILGSGLEIGTLSGYIAASVIVTiltllltdeq 194
Cdd:cd17490 84 S--------PWGLLIARFLSGIAAATWVSFTVLYASYFPPDeaaKAMGLINLVNNLGQLIAFLIGGLIAE---------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 195 mlSWGWRIPFLIAAPIGLVGLYLRRHLDEspifeemekaQEESEDNEQFSFMDILKYHKKDFLLstvIVAFFNITNYMIL 274
Cdd:cd17490 146 --HFGMRAPFLLAALAGVLGFILSLFIKE----------ERREKKPVLTELKELLSVLKDKKLL---FFSLLAILQQMIT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 275 SYIPSYLT-QVLKVKETTGLLIISITMALMIP--LALYFG--KLSDKIGNKRVVQIG--LLGLTVFAIPaflligngHIA 347
Cdd:cd17490 211 FSTTFGFTpLIAKQLGASSFQLGLLSIIYLLPnaLASLLSgtLFYKKLGERNTIIIGflLLGAYCFLIP--------FAP 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 348 AIFAgIFVLGFFLSVYEGTLPSLLPSLFFTDVRYRALSISFNISVSIFG-GTT--PLVCSYLVHATGnpLAPAFYLAGVS 424
Cdd:cd17490 283 NLTL-LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYAlGMFlgPVLVGIISEAFG--LQTGFFVIGVI 359
|
410
....*....|..
gi 447109680 425 IIGLVVFSVLFV 436
Cdd:cd17490 360 ALLAAILSLAYY 371
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
80-237 |
4.30e-03 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 39.52 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 80 PIGGVF----FGRIGDKYGRK--IVLSTTI-----ILMALSTLFiallPTYEqigvwapiLLLVARMIQGFSTGGEYSGA 148
Cdd:cd17432 60 PLGGLFgsllVGPLVIRLGRKgtLLLNNIFaivaaILMGLSKIA----KSFE--------MIIVGRFLVGINAGISLNVV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 149 MVYIAESSPDKKRGILGSGLEIGTLSGYIAASvIVTILTLLLTDEqmlswGWRIPF-LIAAPiGLVGLYLRRHLDESPIF 227
Cdd:cd17432 128 PMYLGESAPKNLRGAVGLVPAIFITLGILLGQ-VLGLRELLGNEE-----GWPLLLaLTGVP-ALLQLLTLPFFPESPRY 200
|
170
....*....|
gi 447109680 228 EEMEKAQEES 237
Cdd:cd17432 201 LLIEKGDEEA 210
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
272-443 |
5.07e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 272 MILSYIPSYLTQVLKVKET--TGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVfaipAFLLIGN-GHIAA 348
Cdd:cd17330 14 IVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAV----SYVLLGLsRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 349 IFAGIFVLGFFlSVYEGTLPSLLPSLffTDVRYRALSISFnISVSIFGGTT--PLVCSYLVHATGnPLAPAFYLAGVSII 426
Cdd:cd17330 90 LFLARFLDGLT-GGNVSVAQAYIADI--TDEEERAKAFGI-ISAAFGLGFIlgPALGGFLSTPYG-YALPFLVAAALALL 164
|
170
....*....|....*..
gi 447109680 427 GLvVFSVLFVTTSGRAL 443
Cdd:cd17330 165 NL-VLVLFFLPPLRRLL 180
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
40-187 |
5.17e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 40 FGLYAYLAVILSQLFFSGVDNSGLqlvLTFATFAVAFLVRPIGGvffgRIGDKYGRKIVLSTTIILMALSTLFIALLptY 119
Cdd:cd17503 195 FGAMFLLPLYLQNVLGYSAFESGL---VLAPGGLASAILSPLVG----RLLDKFGPRLLLLAGLLLLALGTLLLAFL--T 265
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 120 EQIGVWapiLLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGiLGSGL--EIGTLSGYIAASVIVTILT 187
Cdd:cd17503 266 PDTSLW---LIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIG-DATALfnTIRQLGGSIGTALLATLLT 331
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
38-372 |
5.57e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.21 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 38 FDFGLYAYLAVILSQLFfsGVDNSGLQLVLTFATFAVAFLVrPIGGVFFGRIGDKYGRK---IVLSTtiILMALSTLFIA 114
Cdd:pfam13347 12 KYAGLATYLLYFYTDVL--GLSAAAVGLVLLVARLVDAFTD-PIVGHIIDRTRTRWGRRrpwLLLSA--IILAVSFILLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 115 LLPTYEQIG--VWAPILLLVARMIQGFSTGGEYSgamvYIAESSPD-KKRGILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:pfam13347 87 TPPELGRAPlfIWLLATYILLRIAYTFFEIPYWS----LGPELTRDyDERTSLTSYRSFFSVGGGLLAAALAFPLVLILG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 192 DEQMLSWGWRIPFLIAAPIGLVGLYL----RRHLDEspifeemEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAF-- 265
Cdd:pfam13347 163 GTGLERKGYRIFALIGAVLMLLGVIItaagTKERVS-------MRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFll 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 266 ----FNITNYMILSYIPSYLTQVLKVKETTGLLIISitMALMIPLALYFGKlsdKIGNKRVVQIGLLGLTVFAIPAFLLI 341
Cdd:pfam13347 236 aalaMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIG--ALLGIPLWPPLAK---RIGKKNTYILGALITIAGFALALLLG 310
|
330 340 350
....*....|....*....|....*....|.
gi 447109680 342 GNgHIAAIFAGIFVLGFFLSVYEGTLPSLLP 372
Cdd:pfam13347 311 PN-NTLLFLVLYIIIGFGYGSSFFLPWSMLA 340
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
44-362 |
6.78e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.76 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 44 AYLAVILSQLffsGVDNSGLQLVLTFATFAvAFLVRPIGGVFFGRIGDKYGRKIVLstTIILMALSTLFIALLPTYEQIG 123
Cdd:cd17313 20 SYVPPILQTL---GLSHALIGFVWTLGPIL-GLFVQPLVGSLSDRCNSRIGRRRPF--ILVGAPLAALGLILIPNAADIG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 124 --------VWAPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR----GILGSGLEIGTLSGYIAASVIVTILTLLLT 191
Cdd:cd17313 94 lalgdgprTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRskanGIINFMGGLGGVLGYLLGAILWDHNWFGFA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 192 DEQMLswgwRIPFLIAAPIGLVGLYLRRHL-DESPIFEEMEKAQEESEDNEQFSFMDILKYHKKDFLLSTVIVAFFNITN 270
Cdd:cd17313 174 LGGNL----KVPFYIGAIILLVCVLVTLFFvKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 271 YM-ILSYIPSYLTQVLKVKETT--------------GLLIISITMALMiplALYFGKLSDKIGNKRVVQIGLLGLTVFAI 335
Cdd:cd17313 250 FFpFELFFTDYMGEEVYHGTSAasshygagvrmgawGLLIFSLAFLIF---SLPIGKLGKKIGRKKVYLIGLVLFAVGMA 326
|
330 340
....*....|....*....|....*..
gi 447109680 336 PAFLLignGHIAAIFAGIFVLGFFLSV 362
Cdd:cd17313 327 LMALV---HNVTVALVLFALGGIGWAT 350
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
83-213 |
8.57e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 38.37 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 83 GVFFGRIGDKYGRKIVLSTTIILMALSTLFIALlptyeqigvwaPILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKR- 161
Cdd:cd17336 55 VLLVSYFGGRGHRPRWIGIGSILMGLGCFLLAL-----------PHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSp 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447109680 162 ---GILGSGLEIGTLSGYIAASVIVTI-------LTLLLTDEQMLSWGWRIPFLIAAPIGLV 213
Cdd:cd17336 124 lyiGILYAMRVLGPALGFLLGSFLLRIyvdfsrvPLGITPDDPRWIGAWWLGFLILGILLLI 185
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-215 |
8.69e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 8.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 40 FGLYAYLAVILSQLFfsGVDNSGLQLVLTFATFAVAflvrpIGGVFFGRI-GDKYGRKIVLSTTIILMALSTLFIALLPT 118
Cdd:cd17474 215 FAFLTYLPFLLELLY--GISPIIIGLLFAGWSVLLA-----LGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPS 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 119 YeqigvwapILLLVARMIQGFSTGGEYSGAMVYIAESSPDKKRGILGSGLEIGTLSGYIAASVIVTILtllltdeqMLSW 198
Cdd:cd17474 288 L--------ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLL--------LEIF 351
|
170
....*....|....*..
gi 447109680 199 GWRIPFLIAAPIGLVGL 215
Cdd:cd17474 352 GLSAPFLVGAAIALAAA 368
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
279-375 |
9.74e-03 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 38.36 E-value: 9.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447109680 279 SYLTQVLKVKETTGLLIISITMALMIPLALYFGKLSDKIGNKRVVQIGLLGLTVFAIPAFLLIGNGHiaaifagIFVLGF 358
Cdd:cd17482 213 IYGAEEGKLGSSALILALLLTQFVAFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWD-------FWILAA 285
|
90
....*....|....*..
gi 447109680 359 FLSVYEGTLPSLLPSLF 375
Cdd:cd17482 286 LIGLVQGGIQALSRSLF 302
|
|
| |
