FtsW/RodA/SpoVE family cell cycle protein similar to peptidoglycan glycosyltransferases FtsW that is essential for cell division and RodA that is involved in peptidoglycan cell wall formation
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ...
19-382
5.71e-91
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division]
Pssm-ID: 274232 Cd Length: 356 Bit Score: 278.29 E-value: 5.71e-91
rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE ...
19-397
1.85e-32
rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE superfamily. It has been reported that RodA proteins play important roles in maintaining cell shape and antibiotic resistance in bacteria.
Pssm-ID: 411566 Cd Length: 415 Bit Score: 126.55 E-value: 1.85e-32
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ...
19-382
5.71e-91
cell division protein FtsW; This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division]
Pssm-ID: 274232 Cd Length: 356 Bit Score: 278.29 E-value: 5.71e-91
rod shape-determining protein RodA; This protein is a member of the FtsW/RodA/SpoVE family ...
19-382
2.77e-83
rod shape-determining protein RodA; This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division]
Pssm-ID: 274033 Cd Length: 352 Bit Score: 258.60 E-value: 2.77e-83
stage V sporulation protein E; This model represents an exception within the members of the ...
19-382
2.71e-61
stage V sporulation protein E; This model represents an exception within the members of the FtsW model TIGR02614. This exception occurs only in endospore-forming genera such as Bacillus, Geobacillus, and Oceanobacillus. Like FtsW, members are found in a peptidoglycan operon context, but in these genera they part of a larger set of paralogs (not just the pair FtsW and RodA) and are required specifically for sporulation, not for viability. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]
Pssm-ID: 131664 Cd Length: 354 Bit Score: 201.93 E-value: 2.71e-61
rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE ...
19-397
1.85e-32
rod shape-determining protein RodA; Proteins of this family are members of the FtsW/RodA/SpoVE superfamily. It has been reported that RodA proteins play important roles in maintaining cell shape and antibiotic resistance in bacteria.
Pssm-ID: 411566 Cd Length: 415 Bit Score: 126.55 E-value: 1.85e-32
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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