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Conserved domains on  [gi|488140892|ref|WP_002212100|]
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MULTISPECIES: type VI secretion system baseplate subunit TssE [Yersinia pseudotuberculosis complex]

Protein Classification

type VI secretion system baseplate subunit TssE( domain architecture ID 10022389)

type VI secretion system (T6SS) baseplate subunit TssE is a component of the T6SS baseplate that serves not only as the tail assembly platform, but also docks the tail to the membrane complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VI_zyme TIGR03357
type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 ...
 12-141 8.39e-43

type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 cites acidic lysozyme activity for some phage-encoded members. This family represents a different subgroup of the proteins from pfam04965, where all members are associated with bacterial type VI secretion system genomic contexts.


:

Pssm-ID: 274540  Cd Length: 133  Bit Score: 138.13  E-value: 8.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   12 SASLFDRIQGKGASSSSDGR--LRELLNSIQKHLNEVLNSRPGACQSAVDLGVIDLNDATATSSDFRKSIEKAIKDCIEN 89
Cdd:TIGR03357   1 TPSLFERLPDASGESPSTRRssAEQLRESIRRHLERLLNTRRGSCASLPDYGLPDLNDLSLSSADDRRRIRRAIEQAIER 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488140892   90 YEPRISAVTVQSLLNHGDPLQLSFHISARVNFDDMGDVVEFNIQLDNNRRYC 141
Cdd:TIGR03357  81 YEPRLSRVRVTALPDEEDPLALRFRIEAELDVDGGPEPVSFDALLDPSGRYR 132
 
Name Accession Description Interval E-value
VI_zyme TIGR03357
type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 ...
 12-141 8.39e-43

type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 cites acidic lysozyme activity for some phage-encoded members. This family represents a different subgroup of the proteins from pfam04965, where all members are associated with bacterial type VI secretion system genomic contexts.


Pssm-ID: 274540  Cd Length: 133  Bit Score: 138.13  E-value: 8.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   12 SASLFDRIQGKGASSSSDGR--LRELLNSIQKHLNEVLNSRPGACQSAVDLGVIDLNDATATSSDFRKSIEKAIKDCIEN 89
Cdd:TIGR03357   1 TPSLFERLPDASGESPSTRRssAEQLRESIRRHLERLLNTRRGSCASLPDYGLPDLNDLSLSSADDRRRIRRAIEQAIER 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488140892   90 YEPRISAVTVQSLLNHGDPLQLSFHISARVNFDDMGDVVEFNIQLDNNRRYC 141
Cdd:TIGR03357  81 YEPRLSRVRVTALPDEEDPLALRFRIEAELDVDGGPEPVSFDALLDPSGRYR 132
COG3518 COG3518
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 1-141 1.03e-36

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442740  Cd Length: 162  Bit Score: 123.55  E-value: 1.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   1 MAALLNWDRgSSASLFDRIQGKGASSSSDGR------LRELLNSIQKHLNEVLNSRPGAC----------QSAVDLGVID 64
Cdd:COG3518    1 MARLRPRRR-LQPSLLDRLTDDEPDRSRESPlsrvvsLEQLRESVRRDLEWLLNTRRGEAsllaaypevrRSVLNYGLPD 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488140892  65 LNDATATSSDFRKSIEKAIKDCIENYEPRISAVTVQSLLNHG-DPLQLSFHISARVNFDDMGDVVEFNIQLD-NNRRYC 141
Cdd:COG3518   80 LSGASLGSPDDREAIERAIRQAILRFEPRLRRVSVTVLPDDDdSPNTLRFRIEAVLWADPAPEPVRFDTVLDlETGRVS 158
GPW_gp25 pfam04965
Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like ...
 33-123 1.75e-21

Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like proteins, found in several systems, including contractile tail bacteriophages, the type VI secretion system (T6SS) and R-type pyocins, which constitute a multiprotein tubular apparatus to attach to and penetrate host cell membranes. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerization, playing a critical role in sheath assembly and contraction. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD). This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.


Pssm-ID: 428225  Cd Length: 93  Bit Score: 82.24  E-value: 1.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   33 RELLNSIQKHLNEVLNSRPGACQSAVDLGVIDLNDATATSSDF-RKSIEKAIKDCIENYEPRISAVTVQSLLNHGDPLQL 111
Cdd:pfam04965   1 SSLRESVRRDLEILLNTRPGERVSRPNYGCPDLALLFAPNDDAtRALIERAIREAILRFEPRIRVVSVEVDPDPDSPGTL 80

                          90
                  ....*....|..
gi 488140892  112 SFHISARVNFDD 123
Cdd:pfam04965  81 RFTIEYTLRATP 92
25 PHA00415
baseplate wedge subunit
 77-138 5.09e-03

baseplate wedge subunit


Pssm-ID: 222788  Cd Length: 131  Bit Score: 34.98  E-value: 5.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488140892  77 KSIEKAIKDCIENYEPRISAVTVQSLLNHGD---PLQLSFHIsarvnFDDMGDVVEFNIQLDNNR 138
Cdd:PHA00415  72 DTIERNIESAIRNYEPRVYNLNVEVIPVYDDnsiIVTIYFSI-----IDNPDDLEQIKFQLSRSR 131
 
Name Accession Description Interval E-value
VI_zyme TIGR03357
type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 ...
 12-141 8.39e-43

type VI secretion system lysozyme-like protein; The description for Pfam family pfam04965 cites acidic lysozyme activity for some phage-encoded members. This family represents a different subgroup of the proteins from pfam04965, where all members are associated with bacterial type VI secretion system genomic contexts.


Pssm-ID: 274540  Cd Length: 133  Bit Score: 138.13  E-value: 8.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   12 SASLFDRIQGKGASSSSDGR--LRELLNSIQKHLNEVLNSRPGACQSAVDLGVIDLNDATATSSDFRKSIEKAIKDCIEN 89
Cdd:TIGR03357   1 TPSLFERLPDASGESPSTRRssAEQLRESIRRHLERLLNTRRGSCASLPDYGLPDLNDLSLSSADDRRRIRRAIEQAIER 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488140892   90 YEPRISAVTVQSLLNHGDPLQLSFHISARVNFDDMGDVVEFNIQLDNNRRYC 141
Cdd:TIGR03357  81 YEPRLSRVRVTALPDEEDPLALRFRIEAELDVDGGPEPVSFDALLDPSGRYR 132
COG3518 COG3518
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 1-141 1.03e-36

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442740  Cd Length: 162  Bit Score: 123.55  E-value: 1.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   1 MAALLNWDRgSSASLFDRIQGKGASSSSDGR------LRELLNSIQKHLNEVLNSRPGAC----------QSAVDLGVID 64
Cdd:COG3518    1 MARLRPRRR-LQPSLLDRLTDDEPDRSRESPlsrvvsLEQLRESVRRDLEWLLNTRRGEAsllaaypevrRSVLNYGLPD 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488140892  65 LNDATATSSDFRKSIEKAIKDCIENYEPRISAVTVQSLLNHG-DPLQLSFHISARVNFDDMGDVVEFNIQLD-NNRRYC 141
Cdd:COG3518   80 LSGASLGSPDDREAIERAIRQAILRFEPRLRRVSVTVLPDDDdSPNTLRFRIEAVLWADPAPEPVRFDTVLDlETGRVS 158
GPW_gp25 pfam04965
Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like ...
 33-123 1.75e-21

Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like proteins, found in several systems, including contractile tail bacteriophages, the type VI secretion system (T6SS) and R-type pyocins, which constitute a multiprotein tubular apparatus to attach to and penetrate host cell membranes. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerization, playing a critical role in sheath assembly and contraction. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD). This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.


Pssm-ID: 428225  Cd Length: 93  Bit Score: 82.24  E-value: 1.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488140892   33 RELLNSIQKHLNEVLNSRPGACQSAVDLGVIDLNDATATSSDF-RKSIEKAIKDCIENYEPRISAVTVQSLLNHGDPLQL 111
Cdd:pfam04965   1 SSLRESVRRDLEILLNTRPGERVSRPNYGCPDLALLFAPNDDAtRALIERAIREAILRFEPRIRVVSVEVDPDPDSPGTL 80

                          90
                  ....*....|..
gi 488140892  112 SFHISARVNFDD 123
Cdd:pfam04965  81 RFTIEYTLRATP 92
25 PHA00415
baseplate wedge subunit
 77-138 5.09e-03

baseplate wedge subunit


Pssm-ID: 222788  Cd Length: 131  Bit Score: 34.98  E-value: 5.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488140892  77 KSIEKAIKDCIENYEPRISAVTVQSLLNHGD---PLQLSFHIsarvnFDDMGDVVEFNIQLDNNR 138
Cdd:PHA00415  72 DTIERNIESAIRNYEPRVYNLNVEVIPVYDDnsiIVTIYFSI-----IDNPDDLEQIKFQLSRSR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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