NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488215135|ref|WP_002286343|]
View 

MULTISPECIES: MDR family MFS transporter [Enterococcus]

Protein Classification

MDR family MFS transporter( domain architecture ID 13025406)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  27052334|26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 23-477 6.51e-105

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 317.98  E-value: 6.51e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpiv 182
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkvIGFLVVGVIFIALFswrqlhlehPFL 262
Cdd:cd17503  154 ------------------------------------------------------YINLPIGILALLLA---------PLL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 ELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 343 MFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVL 422
Cdd:cd17503  251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488215135 423 TNVTKANIPSKsvldnTPLAYKDQAINATLSGYHAAFIVAIIFGILGFIIAFLLK 477
Cdd:cd17503  331 TNRTQFHHSRL-----SELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 23-477 6.51e-105

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 317.98  E-value: 6.51e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpiv 182
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkvIGFLVVGVIFIALFswrqlhlehPFL 262
Cdd:cd17503  154 ------------------------------------------------------YINLPIGILALLLA---------PLL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 ELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 343 MFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVL 422
Cdd:cd17503  251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488215135 423 TNVTKANIPSKsvldnTPLAYKDQAINATLSGYHAAFIVAIIFGILGFIIAFLLK 477
Cdd:cd17503  331 TNRTQFHHSRL-----SELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 18-429 1.96e-95

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 296.98  E-value: 1.96e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   18 LLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGT 97
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGM 177
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  178 VLPIVVLVLVLAFFLMKSVIPLSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFL-VVGVIFIALFSWRQLH 256
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILsITGLVAIIAFVVWELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  257 LEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAK 336
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  337 RLAITGMFILTAATAPFAF-LTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGT 415
Cdd:TIGR00711 322 KLVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410
                  ....*....|....
gi 488215135  416 AILISVLTNVTKAN 429
Cdd:TIGR00711 402 ALITTILTNRTQFH 415
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-413 3.36e-39

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 145.12  E-value: 3.36e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  13 PYNRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTI 92
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  93 FLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWR 172
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 173 DLFGMVLpivvlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkVIGFLVVGVIFIAL-FS 251
Cdd:COG2814  165 WVFLVNA--------------------------------------------------------VLALLALLLLLRLLpES 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 252 WRQLHLEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFD 331
Cdd:COG2814  189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 332 KYGAKRLAITGMFILTAATAPFAFltkTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIAS 411
Cdd:COG2814  269 RFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                 ..
gi 488215135 412 SI 413
Cdd:COG2814  346 PL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
23-415 3.23e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 117.52  E-value: 3.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   23 LLIGTFCTVLNQTLLTTAFP-TLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCF 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  102 TAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpi 181
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  182 vvlvlvlafflmksviplsnpsidILSAILSTIGFgsllygfssvgddgwgslkVIGFLVVGVIFIALFSWRQLHLEHPF 261
Cdd:pfam07690 155 ------------------------LILAILSLLAA-------------------VLLLLPRPPPESKRPKPAEEARLSLI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  262 LELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYiQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAIT 341
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  342 GMFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGT 415
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK10504 PRK10504
putative transporter; Provisional
 26-417 6.20e-24

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 104.43  E-value: 6.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  26 GTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPN 105
Cdd:PRK10504  18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 106 FSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGMVLPIVVLV 185
Cdd:PRK10504  98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 186 LVLAFFLMKSvIPLSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLVVGVIFIALFSWRQLHLEHPFLELR 265
Cdd:PRK10504 178 AIATLMLMPN-YTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLK 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 266 VFKSSTFTIAavLAGvTNMAMVGAEMV---VPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:PRK10504 257 LFRTRTFSLG--LAG-SFAGRIGSGMLpfmTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVAT 333

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215135 343 MFILTAATAPFAF--LTKTTPVLYIVILYAIRMFGISMVMMPVTTsgMNALPNNLISHGTAVNNTFRQIASSIGTAI 417
Cdd:PRK10504 334 TLGLALVSLLFMLvaLLGWYYLLPFVLFLQGMVNSTRFSSMNTLT--LKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 23-477 6.51e-105

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 317.98  E-value: 6.51e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpiv 182
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkvIGFLVVGVIFIALFswrqlhlehPFL 262
Cdd:cd17503  154 ------------------------------------------------------YINLPIGILALLLA---------PLL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 ELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 343 MFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVL 422
Cdd:cd17503  251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488215135 423 TNVTKANIPSKsvldnTPLAYKDQAINATLSGYHAAFIVAIIFGILGFIIAFLLK 477
Cdd:cd17503  331 TNRTQFHHSRL-----SELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 18-429 1.96e-95

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 296.98  E-value: 1.96e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   18 LLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGT 97
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGM 177
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  178 VLPIVVLVLVLAFFLMKSVIPLSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFL-VVGVIFIALFSWRQLH 256
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILsITGLVAIIAFVVWELT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  257 LEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAK 336
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  337 RLAITGMFILTAATAPFAF-LTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGT 415
Cdd:TIGR00711 322 KLVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401

                         410
                  ....*....|....
gi 488215135  416 AILISVLTNVTKAN 429
Cdd:TIGR00711 402 ALITTILTNRTQFH 415
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 23-477 1.01e-52

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 181.99  E-value: 1.01e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGMVlpiv 182
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN---- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkvigfLVVGVIFIALfswrqlhlehpfl 262
Cdd:cd17321  157 ---------------------------------------------------------VPIGLVALLL------------- 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 elrvfkSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:cd17321  167 ------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 343 MFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVL 422
Cdd:cd17321  241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488215135 423 TNVTKANIPsksvlDNTPLAYKDQAINATLSGYHAAFIVAIIFGILGFIIAFLLK 477
Cdd:cd17321  321 TAGLSANLG-----DSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-413 3.36e-39

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 145.12  E-value: 3.36e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  13 PYNRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTI 92
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  93 FLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWR 172
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 173 DLFGMVLpivvlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkVIGFLVVGVIFIAL-FS 251
Cdd:COG2814  165 WVFLVNA--------------------------------------------------------VLALLALLLLLRLLpES 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 252 WRQLHLEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFD 331
Cdd:COG2814  189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 332 KYGAKRLAITGMFILTAATAPFAFltkTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIAS 411
Cdd:COG2814  269 RFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                 ..
gi 488215135 412 SI 413
Cdd:COG2814  346 PL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 23-420 8.02e-37

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 138.47  E-value: 8.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDiSASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGmvlpiv 182
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY------ 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksvIPLsnPSIDILSAILSTIGFGSLlygfssvgddgwgslkvIGFLVVGVIFIALFSwrqlhlehpfl 262
Cdd:cd17502  154 --------------INL--PIGGLALALLRTILLSSI-----------------FGFLFGGALFGLIYY----------- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 elrvfksstftiaavlagvtnmamvgaemvVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYG-AKRLAIT 341
Cdd:cd17502  190 ------------------------------LPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVI 239

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488215135 342 GMFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILIS 420
Cdd:cd17502  240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDV 318
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 23-477 3.55e-34

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 131.93  E-value: 3.55e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVsMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGMvlpiv 182
Cdd:cd17504   81 APNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT----- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkVIGFLVVGVIFIalfswrqlhlehPFL 262
Cdd:cd17504  155 -----------------------------------------------------AAPVAVLLAALV------------PLI 169

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 ELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIR----GESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRL 338
Cdd:cd17504  170 DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 339 AITGMFILTAATApfAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAIL 418
Cdd:cd17504  250 LLIGLVISAVGLL--LLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488215135 419 ISVLTNVTKANIPSKSvldntplaykdqainATLSGYHAAFIVAIIFGILGFIIAFLLK 477
Cdd:cd17504  328 GAILTTYTVSITSGGV---------------PTEGAYVLAFLIGAALALAALLLSLLIP 371
MFS_1 pfam07690
Major Facilitator Superfamily;
23-415 3.23e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 117.52  E-value: 3.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   23 LLIGTFCTVLNQTLLTTAFP-TLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCF 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  102 TAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpi 181
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  182 vvlvlvlafflmksviplsnpsidILSAILSTIGFgsllygfssvgddgwgslkVIGFLVVGVIFIALFSWRQLHLEHPF 261
Cdd:pfam07690 155 ------------------------LILAILSLLAA-------------------VLLLLPRPPPESKRPKPAEEARLSLI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  262 LELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYiQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAIT 341
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  342 GMFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGT 415
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK10504 PRK10504
putative transporter; Provisional
 26-417 6.20e-24

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 104.43  E-value: 6.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  26 GTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPN 105
Cdd:PRK10504  18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 106 FSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGMVLPIVVLV 185
Cdd:PRK10504  98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 186 LVLAFFLMKSvIPLSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLVVGVIFIALFSWRQLHLEHPFLELR 265
Cdd:PRK10504 178 AIATLMLMPN-YTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLK 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 266 VFKSSTFTIAavLAGvTNMAMVGAEMV---VPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:PRK10504 257 LFRTRTFSLG--LAG-SFAGRIGSGMLpfmTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVAT 333

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215135 343 MFILTAATAPFAF--LTKTTPVLYIVILYAIRMFGISMVMMPVTTsgMNALPNNLISHGTAVNNTFRQIASSIGTAI 417
Cdd:PRK10504 334 TLGLALVSLLFMLvaLLGWYYLLPFVLFLQGMVNSTRFSSMNTLT--LKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-418 7.73e-24

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 102.64  E-value: 7.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  16 RTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLI 95
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  96 GTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 176 gmvlpivvlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgslkvIGFLVVGVIFIALFSWrql 255
Cdd:COG2271  168 -------------------------------------------------------------LILGLPGLLLALLRFW--- 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 256 hlehpflelrvfksstftIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGa 335
Cdd:COG2271  184 ------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG- 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 336 KRLAITGMFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGT 415
Cdd:COG2271  245 RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324


                 ...
gi 488215135 416 AIL 418
Cdd:COG2271  325 LLV 327
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 15-297 4.22e-23

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 99.11  E-value: 4.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  15 NRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFL 94
Cdd:COG0477   11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  95 IGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDL 174
Cdd:COG0477   91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 175 FGMVLPIVVLVLVLAFFLMKSVIPLSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLVVGVIFIALFSWRQ 254
Cdd:COG0477  171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 488215135 255 LHLEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYI 297
Cdd:COG0477  251 LLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 23-414 1.57e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 98.80  E-value: 1.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpiv 182
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplsnpsidILSAILSTIGFgsllygfssvgddgwgsLKVIGFLVVGVIFIALFSWRQLHLEHPFL 262
Cdd:cd17325  154 -----------------------LVCAALALLAL-----------------VLALLLLPEPRPPPNKRAVSAARLRSGLR 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 ELRvfKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:cd17325  194 LLL--RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488215135 343 MFILTAATAPFAFltkTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIG 414
Cdd:cd17325  272 LLLSAVALLLLPL---ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 20-431 1.94e-21

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 95.72  E-value: 1.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTIT 99
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 100 CFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGMvl 179
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 180 pivvlvlvlafflmksviplsnpsidilsailstigfgsllygfssvgddgwgsLKVIGFLVVGVIFIALFSWRQLHLEH 259
Cdd:cd17320  159 ------------------------------------------------------LALLGLLLLLLVLLFLPETLPEEKRK 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 260 PFLE------LRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKY 333
Cdd:cd17320  185 PLLSsllrayKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 334 GAKRLAITGMFILTAATA--PFAFLTKTTPVLYIVILYAIRMFGISMvMMPVTTSGMNALPNNLISHGTAVNNTFRQIAS 411
Cdd:cd17320  265 GPRRLLRLGLLLLLAAALvlLLAALLGGLSLWPLVAPLFLIFFGFGL-IFPNATSLALEPFPHVAGTASALLGFLQFLIG 343

                        410       420
                 ....*....|....*....|
gi 488215135 412 SIGTAiLISVLTNVTKANIP 431
Cdd:cd17320  344 ALAGA-LVGLLPNGTALPMG 362
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 21-477 2.26e-20

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 93.85  E-value: 2.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  21 VVLLIGTFCTVLNQTLLTTAFPTLMKAFDiSASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITC 100
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 101 FTAPNFSTLLIGRLIQACGVGVSmPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYH--WRDLFGMV 178
Cdd:cd06179   80 GTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 179 LPIVVLVLVLAFFLM--KSVIPLSNPS-------IDILSAILSTIGFGSLLYGFSSVGDD-GWGSLKVIGFLVVGVIFIA 248
Cdd:cd06179  159 AIFNALALILLFFFYhpPPRPQLHGSStrqklkrLDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAPLVIGGVLLI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 249 LFSWRQLH--LEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVT 326
Cdd:cd06179  239 AFGLYEWKgtKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 327 GAIFDKYG-AKRLAITGMFILTAATAPFAFLTKTTPVLYIVILyAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNT 405
Cdd:cd06179  319 GLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDNKALAIAFS-VLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGS 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 406 FRQIASSIGTAILISVLTN-------------VTKANIPSKSVLDNTPLAYKDQ-----------------AINATLSGY 455
Cdd:cd06179  398 ARALGGAVGTAIFTSILSNrlsknlparvapaALEAGLPASSLPALLGALASGNiaaltavpginpeiiaaATAALKQAY 477

                        490       500
                 ....*....|....*....|....*.
gi 488215135 456 HAAF----IVAIIFGILGFIIAFLLK 477
Cdd:cd06179  478 ADSFryvwYAAIPFGVVAIIAALFLR 503
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
15-382 4.12e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 91.87  E-value: 4.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  15 NRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFL 94
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  95 IGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDL 174
Cdd:COG2223   82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 175 FGmvlpivvlvlvlafflmksviplsnpsidILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLvvgvifialfswrq 254
Cdd:COG2223  162 FL-----------------------------ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 255 lhlehpfleLRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYG 334
Cdd:COG2223  199 ---------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG 269

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 488215135 335 AKRLAITGMFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMP 382
Cdd:COG2223  270 GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 20-417 4.30e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 88.76  E-value: 4.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTIT 99
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 100 CFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMG--MSGIVIGLapALGPTLSGYIIDNYHWRDLFGm 177
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGlvFSGLTLGL--VLGRPLGGLLGQLLGWRAAFL- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 178 vlpivvlvlvlafflmksviplsnpsidiLSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGflvvgvifialfswrqlhl 257
Cdd:cd17324  158 -----------------------------AIAVLALLAALLLWRLLPSLPPKKPGSLGLLS------------------- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 258 ehpfLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKR 337
Cdd:cd17324  190 ----SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 338 LAITGMFILTAATAPFAFLTKTTPVLYIVILYAirmFGISMVMMPVTTSGMNALPNNLiSHGTAVNNTFRQIASSIGTAI 417
Cdd:cd17324  266 LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWG---LGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAAL 341
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 20-414 7.48e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 88.01  E-value: 7.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTIT 99
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 100 CFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDnYHWRDLFGMVL 179
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 180 PIVVLVLVLAFFLM----KSVIPLSNPSIDILSAILSTIGFGSllygfssvgddgwgslkvigFLVVGVIFIALFswrql 255
Cdd:cd17474  160 ALIPVAFLAILFLLpepkEKAKSSSATKLRDLKKALRGRGLLT--------------------FLVSAFLYFFLY----- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 256 hlehpflelrvfksstFTIAAVLagvtnmamvgaemvvPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDK-YG 334
Cdd:cd17474  215 ----------------FAFLTYL---------------PFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFG 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 335 AKRLAITGMFILTAATAPFAFLTKTTPVLYIVILYAIrmfGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIG 414
Cdd:cd17474  264 ARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL---GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
PRK14995 PRK14995
SmvA family efflux MFS transporter;
35-430 3.88e-16

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 80.54  E-value: 3.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  35 TLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRL 114
Cdd:PRK14995  23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 115 IQACGVGVSMPLLQNIMLSIFPPEK-RGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGMVLPIVVLVLVLAFFLM 193
Cdd:PRK14995 103 LLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 194 KSVIPLSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLVVGVIFIALFSWRQLHLEHPFLELRVFKSSTFT 273
Cdd:PRK14995 183 PRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRIIL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 274 IAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITGMFILTAATAPF 353
Cdd:PRK14995 263 SGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFYGL 342

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215135 354 AFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVLTNVTKANI 430
Cdd:PRK14995 343 AMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSYSASI 419
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 20-175 1.33e-15

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 78.39  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTIT 99
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488215135 100 CFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:cd17323   81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-422 7.31e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.84  E-value: 7.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWrdlfgmvlpiv 182
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 183 vlvlvlafflmksviplSNPSIDILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLVVGVIFialfswrqlhlehpfl 262
Cdd:cd06174  150 -----------------GWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL---------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 263 eLRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITG 342
Cdd:cd06174  197 -KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 343 MFILTAATapFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVL 422
Cdd:cd06174  276 GLLLMALG--LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
2_A_01_02 TIGR00880
Multidrug resistance protein;
57-175 1.20e-13

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 68.06  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   57 WLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFP 136
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 488215135  137 PEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPF 120
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 14-175 2.82e-13

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 71.26  E-value: 2.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   14 YNRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIF 93
Cdd:TIGR00710   1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   94 LIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRD 173
Cdd:TIGR00710  81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160


                  ..
gi 488215135  174 LF 175
Cdd:TIGR00710 161 IF 162
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-177 3.03e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 67.98  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   1 MSNNQPVDIYGKPYNRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKF 80
Cdd:COG2807    1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  81 SSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFpPEKRGSAMGMSGIVIGLAPALGPT 160
Cdd:COG2807   81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAG 159

                        170
                 ....*....|....*..
gi 488215135 161 LSGYIIDNYHWRDLFGM 177
Cdd:COG2807  160 LTVPLAAALGWRGALAV 176
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 16-426 6.05e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 66.83  E-value: 6.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  16 RTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLI 95
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  96 GTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 176 gmvlpivvlvlvlafflmksviplsnpsidILSAILSTI-GFGSLLYGFSSVGDdgwgslkVIGFLVVGVIFIALFSWrq 254
Cdd:cd17319  161 ------------------------------IIEGLLGLLlAVLWWFYLRQVWGL-------ALGYFGINYALYGLLTW-- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 255 lhlehpflelrvfksstftiaavlagvtnmamvgaemvVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYG 334
Cdd:cd17319  202 --------------------------------------LPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 335 AKRLAITGMFILTAATAPFAFLTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIG 414
Cdd:cd17319  244 RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA 323

                        410
                 ....*....|..
gi 488215135 415 tAILISVLTNVT 426
Cdd:cd17319  324 -PLLIGYLVDAT 334
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 19-172 1.68e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 65.67  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  19 LVVVLLIGTFcTVLNQTLLTTAFPTLMKAF-DISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGT 97
Cdd:cd17473    1 LITLLLASTL-TVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488215135  98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDnYHWR 172
Cdd:cd17473   80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWR 153
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 36-418 1.06e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.00  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  36 LLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLI 115
Cdd:cd17489   14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 116 QACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpivvlvlvlafflmks 195
Cdd:cd17489   94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF-------------------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 196 viplsnpsidILSAILSTIGFGSLLY----GFSSVGDDGWGSLKVIGFLVVGVIFIALfswrqlhlehpflelrvfksST 271
Cdd:cd17489  154 ----------IVAAVLALLALLLVFLvkdpPPVAAEEAEAGTRAFRRLVEKKVLPPAL--------------------IL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 272 FTIAAVLAGVTNMamvgaemvVPLYIQNIRGESAfhsGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITGMFILTAATA 351
Cdd:cd17489  204 FLASIAYGAISTF--------LPLYAAERGISNA---GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLL 272

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215135 352 PFAFLTKTTPVLYIVILYAIrmfGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAIL 418
Cdd:cd17489  273 LLSFAGSPWMLLLAAVLYGL---GFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-177 1.30e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.97  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  18 LLVVVLLIGTFCTVLNQTLLTTAFPT-LMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRN--LYLSAMTIFL 94
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  95 IGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDL 174
Cdd:COG2271  260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339


                 ...
gi 488215135 175 FGM 177
Cdd:COG2271  340 FLL 342
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 19-175 1.98e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.13  E-value: 1.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  19 LVVVLLIGTFCTVLNQTLLTTAFPTLMKA-FDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGT 97
Cdd:cd17325  200 RLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488215135  98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:cd17325  280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
15-166 3.88e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 58.33  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  15 NRTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFL 94
Cdd:COG0738    5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488215135  95 IGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLqNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYII 166
Cdd:COG0738   85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAA-NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI 155
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
206-423 1.56e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.83  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 206 ILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIG--FLVVGVIFIALFSWRQLHLEHPFLELR-----VFKSSTFTIAAVL 278
Cdd:COG2211  157 GLGGLLASVLPPPLVAAFGGDAALGYRLTALIFavLGLLAFLLTFFGTKERPVPEEEKVSLKeslkaLLKNRPFLLLLLA 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 279 AGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITGMFILTAATAPFAFLTK 358
Cdd:COG2211  237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP 316

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488215135 359 TTPVLyIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHG-------TAVNNTFRQIASSIGTAILISVLT 423
Cdd:COG2211  317 GNLWL-LLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLA 387
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-167 4.52e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 4.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  16 RTLLVVVLLIGTFCTVLnqtLLTTAFPTLMK-AFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFL 94
Cdd:COG2223  206 RFWLLSLLYFGTFGSFI---GFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  95 IGTITCFTAP-NFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIID 167
Cdd:COG2223  283 LGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD 356
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 15-175 6.00e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.50  E-value: 6.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  15 NRTLLVVVLLIGTFCTVLNQTLltTAFPTLMKA-FDISASDVQWLTTGFLLVNGIMIPITAWLINK-FSSRNLYLSAMTI 92
Cdd:cd17474  197 GRGLLTFLVSAFLYFFLYFAFL--TYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  93 FLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWR 172
Cdd:cd17474  275 YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS 354


                 ...
gi 488215135 173 DLF 175
Cdd:cd17474  355 APF 357
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 23-161 9.40e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 54.10  E-value: 9.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFT 102
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488215135 103 APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTL 161
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL 139
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 42-169 9.44e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 54.15  E-value: 9.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  42 PTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWL-INKFSSRNLylsAMTIFLIGTITCFTAPNFSTLLIGRLIQAC-- 118
Cdd:cd17490  219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNT---IIIGFLLLGAYCFLIPFAPNLTLLYLLQALng 295

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488215135 119 -GVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNY 169
Cdd:cd17490  296 fGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAF 347
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 19-172 1.18e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.78  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  19 LVVVLLIGTFCTVLNQTLlTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTI 98
Cdd:cd17328    1 VAVLFLINLLNYMDRFTI-AGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488215135  99 TCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIID-NYHWR 172
Cdd:cd17328   80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWR 154
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 13-175 1.90e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 53.13  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   13 PYNRTLLVVVLL--IGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLvnGIMIP--ITAWLINKFSSRNLYLS 88
Cdd:TIGR00895  10 PLSRYQWRAIILsfLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLI--GMAFGalFFGPLADRIGRRRVLLW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   89 AMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMG--MSGIVIGLApaLGPTLSGYII 166
Cdd:TIGR00895  88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGlmFCGYPIGAA--VGGFLAGWLI 165


                  ....*....
gi 488215135  167 DNYHWRDLF 175
Cdd:TIGR00895 166 PVFGWRSLF 174
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 25-419 2.52e-07

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 52.72  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   25 IGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYlsAMTIFLIGTITCFTA- 103
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTL--AVFIVIWGVFTGLQAf 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  104 -PNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgmvlpiv 182
Cdd:TIGR00893  79 aGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAF------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  183 vlvlvlafflmksviplsnpsidILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGFLVVGVIFIALFSwRQLHLEHPFL 262
Cdd:TIGR00893 152 -----------------------IIEGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQG-KGPSTPKKYQ 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  263 ELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGESAFHSGLM-LLPGALIMGAMmpVTGAIFDKYGAKR---- 337
Cdd:TIGR00893 208 IKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMaSLPGIVGFIGM--ILGGRLSDLLLRRgksl 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  338 ------LAITGMFiltAATAPFAFlTKTTPVLYIVILYAIRMFGISMVMMPVTTSGMNAlPNNLISHGTAVNNTFRQIAS 411
Cdd:TIGR00893 286 vfarktAIIAGLV---LSLLMFAT-NYVNIPYAALALVALGFFGLGAGAIGWALISDNA-PGNIAGLTGGLINSLGNLGG 360


                  ....*...
gi 488215135  412 SIGTAILI 419
Cdd:TIGR00893 361 IVGPIVIG 368
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
15-167 2.78e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.60  E-value: 2.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  15 NRTLLVvvLLIGTFCTVLNQTLLTTAFPTLMK-AFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIF 93
Cdd:COG2211  227 NRPFLL--LLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  94 LIGTITCFTAP--NFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEK-------RGSAMGMSGIVIGLAPALGPTLSGY 164
Cdd:COG2211  305 ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGL 384


                 ...
gi 488215135 165 IID 167
Cdd:COG2211  385 LLA 387
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 23-417 4.82e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.85  E-value: 4.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNL-----YLSAMTIFLIGT 97
Cdd:cd06173    4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFgm 177
Cdd:cd06173   84 LALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF-- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 178 vlpivvlvlvlafflmksviplsnpSIDILSAILSTIGFGSLLYGFSSVGDdgwgslkvigflvvgvifialfSWRQLHL 257
Cdd:cd06173  162 -------------------------AINALSFLLSALLLLFIRRPPPAAPG----------------------ESSSLLL 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 258 EHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMV-VPLYIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAK 336
Cdd:cd06173  195 RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVlLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 337 RLAITGMFILTAATAPFAFltkTTPVLYIVILYAIRMFGISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTA 416
Cdd:cd06173  275 RLLLIGALLLGLALLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351


                 .
gi 488215135 417 I 417
Cdd:cd06173  352 L 352
emrD PRK11652
multidrug transporter EmrD;
19-172 2.11e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 49.91  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  19 LVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTI 98
Cdd:PRK11652   9 LLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  99 TCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWR 172
Cdd:PRK11652  89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWR 162
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 17-170 4.64e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 4.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  17 TLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDI-SASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLI 95
Cdd:cd17473  196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488215135  96 GTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYH 170
Cdd:cd17473  276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 36-175 5.53e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 48.45  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  36 LLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLI 115
Cdd:cd17371   17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135 116 QACGVGVSMPLLQNIMLSIFPPEKRGSAMG--MSGIVIG--LAPALGPTLSGYIIDNYHWRDLF 175
Cdd:cd17371   97 AGLGFGGEWAAGAALMAEYVPARHRGKALGyvQSGWAVGwlLATLLAALLFPLLPPEIAWRVLF 160
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 16-448 5.55e-06

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 48.84  E-value: 5.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  16 RTLLVVVLLIGTFCTVLNQTLLTTAFPTLMKAFDiSASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLI 95
Cdd:cd17322    1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFS-KHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  96 GTITCFTAPNFSTLLIGRLIQACGVgVSMPLLQNIMLSIFPPEK-RGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDL 174
Cdd:cd17322   80 GTIIMAASTNVQTYAAGSVFYNAGY-TGLNLLLTLILADFSSLKnRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 175 FGMVLPIVVLVLVLAFFLM--------KSVIPLSNPS--------------------IDILSAILSTIGFGSLLYGFSSV 226
Cdd:cd17322  159 YGMWAIILPLSSLPLVLCLlymqrkarKDGEIKELKNqeteeqtgglsqnlvklfwkLDIFGVILLTAGLGLILVPLTLA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 227 GDD--GWGSLKVIGFLVVG-VIFIALFSWRQLHLEHPFLELRVFKSSTFTIAAVLAGVTNMAMVGAEMVVPLYIQNIRGE 303
Cdd:cd17322  239 GGAksKWKNSSIIAMIVLGgVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 304 SAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKR--------LAITGMFILtaatapFAFLTKTTPVLYIVILYAIRMFG 375
Cdd:cd17322  319 SITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKvlviigvpLYIVGMGLL------IRYRGGSGSHGGIIGALILIGIG 392

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215135 376 ISMVMMPVTTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVLTNvtkaNIPSKsVLDNTPLAYKDQAI 448
Cdd:cd17322  393 GGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQ----TLPKK-LLKNLPDSLKATAA 460
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 21-177 5.76e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 48.41  E-value: 5.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  21 VVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITC 100
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488215135 101 FTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGS-AMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGM 177
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 16-166 6.54e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.32  E-value: 6.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  16 RTLLVVVLLIGTFCTVLNQTLLTTAFpTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLI 95
Cdd:cd17321  168 RTFSGAVLAAFLLGAALGGLLFLLPL-YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  96 GTI---TCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYII 166
Cdd:cd17321  247 GLLllaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 20-169 1.65e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKafdISASDVQWLTTGFLLVNGIMI----PITAWLINKFSSRNLYLSAMTIFLI 95
Cdd:cd17329  202 FLLFLLASFLISLIYFQLESTLPVYVV---EILGLGESLLGLLLALNALLIvllqFPVARLVERFRLRKILMIGILLFAI 278

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  96 GTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNY 169
Cdd:cd17329  279 GFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL 352
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 62-177 2.59e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.43  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  62 FLLVNGIMI----PITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPP 137
Cdd:cd17489  232 FFTVYAIALllsrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488215135 138 EKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGM 177
Cdd:cd17489  312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLL 351
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-167 2.63e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.27  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPT-LMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSR-NLYLSAMTIFLIGT 97
Cdd:cd06174  205 LWLLLLAIFLVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALGL 284

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIID 167
Cdd:cd06174  285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 20-170 3.48e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.06  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKA-FDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTI 98
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  99 TCFTAP--NFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYH 170
Cdd:cd17316  259 PLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 16-177 3.97e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.62  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  16 RTLLVVVLLIGTFCTVLNQTLLTTAF-PTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFL 94
Cdd:cd17324  196 RNPRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  95 IGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIfPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDL 174
Cdd:cd17324  276 ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV 354


                 ...
gi 488215135 175 FGM 177
Cdd:cd17324  355 GWV 357
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 44-368 9.17e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.57  E-value: 9.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  44 LMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGR-LIQACGVGV 122
Cdd:cd17355   29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGGGGAGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 123 SMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGmvlpivvlvlvlafflmksviplsnp 202
Cdd:cd17355  109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL-------------------------- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 203 sidILSAILSTIGFGSLLYGFSSVGDDGWGSLKVIGflvvgvifialfswrqlHLEHPFLELRVFKSSTFTIAAVLAGVT 282
Cdd:cd17355  163 ---VLALLALLVLVPVLLLLRRRPADLALRAYDDAS-----------------PASPGSTLKEALRSASFWLLALAFFLC 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 283 NMAMVGAEMVVPLYIQNiRGESAFHSGLMLlpgALIMGAMM---PVTGAIFDKYGAKRLAITGMFILTAATAPFAFLTKT 359
Cdd:cd17355  223 GFAVVGLIVHLVPYLAD-RGISPAAAAVAL---ALIGLFNIvgrLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFP 298


                 ....*....
gi 488215135 360 TPVLYIVIL 368
Cdd:cd17355  299 PLALLLFAA 307
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 23-175 1.33e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.11  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  23 LLIGTFCTVL---NQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTIT 99
Cdd:cd17365    1 LALCFLIIVLdgfDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488215135 100 CFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMG--MSGIVIGlaPALGPTLSGYIIDNYHWRDLF 175
Cdd:cd17365   81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTlmFCGYPLG--AALGGFLAAALIPAFGWRSVF 156
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 20-169 1.99e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKA-FDISASDVQWLTTGFLLVNGIM-IPITAWLINKFSSRNLYLSAMTIFLIGT 97
Cdd:cd17330  176 LRRLLLVYFLIALAFAGLESVFSLFLKDrFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488215135  98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNY 169
Cdd:cd17330  256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 36-171 2.24e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.46  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  36 LLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLI 115
Cdd:cd17333   14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFL 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488215135 116 QACGVGVSMPLLQNIMLSIFpPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHW 171
Cdd:cd17333   94 AGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELS 148
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 40-177 2.66e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 43.32  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  40 AFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACG 119
Cdd:cd17359   23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488215135 120 VGVSMPLLQNIMLSIFPPEKRGSAMGMS--GIVIGLAPA------LGPTLSGYIIDNYHWRDLFGM 177
Cdd:cd17359  103 VGGASALVPMYIAEVAPAEIRGRLVSLNqlMIVFGQLLAyivnylIANAGGADWLGAEGWRWMLGL 168
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 296-383 5.83e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.13  E-value: 5.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 296 YIQNIRGESAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITGMFILTAATAP-FAFLTKTTPVLYIVILYAIRMF 374
Cdd:cd17369  254 YATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPfFWLLDTGSTWLIVLAAVVVLGV 333


                 ....*....
gi 488215135 375 GISMVMMPV 383
Cdd:cd17369  334 LHGMMYGPQ 342
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-169 6.97e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  19 LVVVLLIGTFCTVLNQTLLTTAFPTLMK-AFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGT 97
Cdd:COG0738  211 RLLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488215135  98 ITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFP--PEKRGSAMGMSGIVIGlapALGPTLSGYIIDNY 169
Cdd:COG0738  291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGkrTAAAVSAVLIMGIVGG---AIGPPLIGFLADAF 361
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 62-176 7.91e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 7.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  62 FLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRG 141
Cdd:cd17370  243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488215135 142 SAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFG 176
Cdd:cd17370  323 TAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 20-170 1.05e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 41.38  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  20 VVVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTIT 99
Cdd:cd17352  185 FVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSL 264

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215135 100 CFT--APNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYH 170
Cdd:cd17352  265 LAFplATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 15-175 1.15e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.06  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  15 NRTLLVVVLLIGTFCTVLnqTLLTTAFPTLMK-AFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIF 93
Cdd:cd06173  207 SPLLRLLLLALALFALLG--GALTVLLPLLAKeVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  94 LIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRD 173
Cdd:cd06173  285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364


                 ..
gi 488215135 174 LF 175
Cdd:cd06173  365 VF 366
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 25-172 1.35e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 40.82  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   25 IGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAP 104
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488215135  105 NFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIdNYHWR 172
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGI-AELYS 148
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 39-424 1.59e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 41.19  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   39 TAFPTLMKafDISASDVQWL-TTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLL--IGRLI 115
Cdd:pfam06609  65 SALPNILQ--DIGQSENQGLfSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLaaMTLLG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  116 QACGVGVSMPLLQNIMLSifppeKRGSAMGMSGIVI------GLAPALGPTLSgyIIDNYHWRDLFGMVLPIVVLVLVLA 189
Cdd:pfam06609 143 VAAGPAGASPLFIGELMS-----NKTKFLGLLIVSAptiamnGAGPYFGQRLA--IQGNWRWIFYIYIIMSAIAVLLIII 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  190 FFLMKSVIPLSN---------PSIDILSAILSTIGFGSLLYGFSSVG--DDGWGSLKVIGFLVVGVIFIALFSWRQLH-- 256
Cdd:pfam06609 216 WYHPPSFAQLHGkkarkrdelAKLDWIGIFLVIAGTSLFLLGVSWGGkpNNPWNSAKIIGLISSGAGSLVIFALYEVFgk 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  257 LEHPFLELRVFKSS----TFTIAAVLAGVTNMAMVgaeMVVPLYIQNIRGESAFH---SGLMLLPGALIMGAMMPVTGAI 329
Cdd:pfam06609 296 PEQPIIPPALFKDTrgfvCILIISSIMGAMHLCLT---IIYPQQVINIFGSSLKNweeTAWMSATASFGTGAGVMILGNL 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  330 FDKYGAKRLAI-TGMFILTAATAPFAFLTKTTPVLYIVILYAIRMF-----GISMVMMPVTTSGMNalpnnlISHGTAVN 403
Cdd:pfam06609 373 FHLIRHIRWQIlVGALWLTAFLGAMSSINRDNKNAAIALSFFSGFVvawaqDITMLLVQFITTDED------LGVAFAVV 446

                         410       420
                  ....*....|....*....|.
gi 488215135  404 NTFRQIASSIGTAILISVLTN 424
Cdd:pfam06609 447 AAARPFAGSIFTAAFISLYSN 467
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 75-141 1.67e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 40.72  E-value: 1.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215135  75 WLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIFPPEKRG 141
Cdd:cd17360   57 WLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRG 123
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 42-175 3.07e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.90  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  42 PTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGR-LIQACGV 120
Cdd:cd17353   27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGA 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488215135 121 GVSMPLLQNIMLSIFpPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:cd17353  107 GIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
40-175 3.44e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.88  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  40 AFPTLMKAFDISASDVQWLTTGFLLvnGIMIPITAW--LINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQA 117
Cdd:PRK11043  28 AFKAIQADLQTSASAVSASLSLFLA--GFALGQLLWgpLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQA 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 118 CGVGVSMPLLQNIMLSIFPPEK--RGSAMGMSgiVIGLAPALGPTLSGYIIDNYHWRDLF 175
Cdd:PRK11043 106 VGVCSAAVIWQALVIDRYPAQKanRVFATIMP--LVALSPALAPLLGAWLLNHFGWQAIF 163
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 50-175 3.68e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  50 ISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQN 129
Cdd:cd17329   32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 488215135 130 IMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDnYHWRDLF 175
Cdd:cd17329  112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLF 156
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 21-173 3.96e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 39.60  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135   21 VVLLIGTFCTVLNQTLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITC 100
Cdd:pfam13347 227 LILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALA 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  101 FTAPNFSTLLIGrLIQACGvGVSMPLLQNIMLSIFP-----------PEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNY 169
Cdd:pfam13347 307 LLLGPNNTLLFL-VLYIII-GFGYGSSFFLPWSMLAdvvdygelrtgKRREGTFFAMWSFISKLATGVGLGVSGLLLSAF 384


                  ....
gi 488215135  170 HWRD 173
Cdd:pfam13347 385 GYNA 388
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 35-171 4.51e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 39.10  E-value: 4.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  35 TLLTTAFPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITcFTAPNFSTLLIGRL 114
Cdd:cd17339   16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILL-RSLGGIALLFLGTA 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488215135 115 IQACGVGVSMPLLQNIMLSIFpPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHW 171
Cdd:cd17339   95 LAGAGIAVGNVLLPSLIKRDF-PRRVGLMTGLYTTSMNLGAALASGLSVPLAQALGG 150
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 41-172 7.66e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 38.69  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  41 FPTLMKAFDISASDVQWLTTGFLLVNGIMIPITAWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGR-LIQACG 119
Cdd:cd17352   26 FVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGLG 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488215135 120 VGVSMPLLQNIMLSIFpPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWR 172
Cdd:cd17352  106 LGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR 157
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 44-172 8.79e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 38.35  E-value: 8.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  44 LMKAFDISASDVQWLTT--GFL--LVNGIMIPitaWLINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACG 119
Cdd:cd17331  234 AMDFFGLTPEENGYLMSyaGVLgmVVQGLLVG---PLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIG 310

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488215135 120 VGVSMPLLQNIMLSIFPPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWR 172
Cdd:cd17331  311 GSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFP 363
PRK03545 PRK03545
putative arabinose transporter; Provisional
 67-177 8.86e-03

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 38.33  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135  67 GIMIPITAW-----------LINKFSSRNLYLSAMTIFLIGTITCFTAPNFSTLLIGRLIQACGVGVSMPLLQNIMLSIF 135
Cdd:PRK03545  47 GLMLTIYAWvvalmslplmlLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVA 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 488215135 136 PPEKRGSAMGMSGIVIGLAPALGPTLSGYIIDNYHWRDLFGM 177
Cdd:PRK03545 127 PAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
304-425 9.26e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 38.31  E-value: 9.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215135 304 SAFHSGLMLLPGALIMGAMMPVTGAIFDKYGAKRLAITGMFILTAATAPFAFltkTTPVLYIVILYAIRMFGISMVMMPV 383
Cdd:COG2271   43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAA 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 488215135 384 TTSGMNALPNNLISHGTAVNNTFRQIASSIGTAILISVLTNV 425
Cdd:COG2271  120 LKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH