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Conserved domains on  [gi|488215430|ref|WP_002286638|]
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MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [Enterococcus]

Protein Classification

Mur ligase family protein( domain architecture ID 11433699)

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

CATH:  3.40.1190.10|3.90.190.20|3.40.50.720
EC:  6.3.2.-
Gene Ontology:  GO:0008764|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 7-453 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 560.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   7 YENKKVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENpEAQELLSLGIKVITGSHPIELLDEeFSLMVKNPGIPYSH 86
Cdd:COG0771    2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPEL-AAAELEAPGVEVVLGEHPEELLDG-ADLVVKSPGIPPDH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  87 PLVAKAQEMGIPVITEVELAYEVAECPIIgitgtngk-tttttmtgLLLNAGADqgiARLAGNIGYPASGVAQEAKSEDK 165
Cdd:COG0771   80 PLLKAARAAGIPVIGEIELAYRLSPAPIIaitgtngktttttlighILKAAGLR---VAVGGNIGTPLLDLLLEPEPPDV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 166 IVMELSSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPF 245
Cdd:COG0771  157 YVLELSSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 246 STKEVLEDGVYADDYSIYYKK--EKIMEISELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEI 323
Cdd:COG0771  237 SLKEPLEGGAGLEDGKLVDRAsgEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEI 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 324 QGRKFYNDSKATNILATKMALSGFEtSKVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIEtIVT 402
Cdd:COG0771  317 NGVRFINDSKATNPDATLAALESFD-GPVVLIAGGLDKGADFSPLAPAVAErVKAVVLIGEDAEKIAAALAGAGVP-VVI 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488215430 403 ADSVEQAVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNRLK 453
Cdd:COG0771  395 VETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 7-453 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 560.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   7 YENKKVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENpEAQELLSLGIKVITGSHPIELLDEeFSLMVKNPGIPYSH 86
Cdd:COG0771    2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPEL-AAAELEAPGVEVVLGEHPEELLDG-ADLVVKSPGIPPDH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  87 PLVAKAQEMGIPVITEVELAYEVAECPIIgitgtngk-tttttmtgLLLNAGADqgiARLAGNIGYPASGVAQEAKSEDK 165
Cdd:COG0771   80 PLLKAARAAGIPVIGEIELAYRLSPAPIIaitgtngktttttlighILKAAGLR---VAVGGNIGTPLLDLLLEPEPPDV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 166 IVMELSSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPF 245
Cdd:COG0771  157 YVLELSSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 246 STKEVLEDGVYADDYSIYYKK--EKIMEISELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEI 323
Cdd:COG0771  237 SLKEPLEGGAGLEDGKLVDRAsgEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEI 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 324 QGRKFYNDSKATNILATKMALSGFEtSKVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIEtIVT 402
Cdd:COG0771  317 NGVRFINDSKATNPDATLAALESFD-GPVVLIAGGLDKGADFSPLAPAVAErVKAVVLIGEDAEKIAAALAGAGVP-VVI 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488215430 403 ADSVEQAVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNRLK 453
Cdd:COG0771  395 VETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 7-452 6.58e-139

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 405.89  E-value: 6.58e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   7 YENKKVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENPEAQELLS-LGIKVITGSHPIELLDEeFSLMVKNPGIPYS 85
Cdd:PRK14106   3 LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQLKEALEELGeLGIELVLGEYPEEFLEG-VDLVVVSPGVPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  86 HPLVAKAQEMGIPVITEVELAYEVAECPIIGITGTNGKTTTTTMT-GLLLNAGADQGIArlaGNIGYPASGVAQEAKSED 164
Cdd:PRK14106  82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLgEIFKNAGRKTLVA---GNIGYPLIDAVEEYGEDD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 165 KIVMELSSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLP 244
Cdd:PRK14106 159 IIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVIF 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 245 FSTKEVLEDGVYADDYSIYY----KKEKIMEISELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYV 320
Cdd:PRK14106 239 FSRKSLLEEGVFVKNGKIVIslggKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 321 GEIQGRKFYNDSKATNILATKMALSGFETSkVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIET 399
Cdd:PRK14106 319 AEINGVKFINDSKGTNPDAAIKALEAYETP-IVLIAGGYDKGSDFDEFAKAFKEkVKKLILLGETAQEIAEAARKYGFDN 397

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488215430 400 IVTADSVEQAVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNRL 452
Cdd:PRK14106 398 ILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 11-451 1.66e-130

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 384.00  E-value: 1.66e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   11 KVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENPEAQELLSLGIKVITGSHPIELLDEEFSLMVKNPGIPYSHPLVA 90
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLHTGLHLEDLNNADLVVKSPGIPPDHPLVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   91 KAQEMGIPVITEVELAYEVAECPIIGITGTNGKTTTTTMTGLLLNAGADQgiARLAGNIGYPASGVAQEAKSeDKIVMEL 170
Cdd:TIGR01087  81 AAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLK--AFLGGNIGTPALEVLDQEGA-ELYVLEL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  171 SSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPFSTKEV 250
Cdd:TIGR01087 158 SSFQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  251 LEDGVYADDysiyyKKEKIMEISELG-VPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEIQGRKFY 329
Cdd:TIGR01087 238 AERGLCIRD-----GGLYLKPNDLEGsLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  330 NDSKATNILATKMALSGFETsKVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIETIVtADSVEQ 408
Cdd:TIGR01087 313 NDSKATNVHATLAALSAFDN-PVILIVGGDDKGADFSPLAPAAAGkVKAVLAIGEDAAKIAPLLKEAGLSVYL-VESLEE 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 488215430  409 AVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNR 451
Cdd:TIGR01087 391 AVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVRA 433
Mur_ligase_M pfam08245
Mur ligase middle domain;
149-293 1.20e-25

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 103.54  E-value: 1.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  149 IGYPASgVAQEAKSE-DKIVMELSSF-----QLMGITdfRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYL 222
Cdd:pfam08245  43 IGLPLT-LAEMVEAGaEYAVLEVSSHglgegRLSGLL--KPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  223 ILNW---NQSELQELAQRTKARVLPFSTKEvlEDGVYADD---------YSIYYKKEKIMEIsELGVPGKHNVENALAAI 290
Cdd:pfam08245 120 VINAddpYGAFLIAKLKKAGVRVITYGIEG--EADLRAANielssdgtsFDLFTVPGGELEI-EIPLLGRHNVYNALAAI 196


                  ...
gi 488215430  291 SVA 293
Cdd:pfam08245 197 AAA 199
AlaDh_PNT_C smart01002
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...
 11-83 1.00e-03

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.


Pssm-ID: 214966 [Multi-domain]  Cd Length: 149  Bit Score: 39.41  E-value: 1.00e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488215430    11 KVLVLGLAKSGVSAAKLLHELGALVTVndgkpFDENPEAQELLS--LGIKVIT---GSHPIELLDEEFSLMVKNPGIP 83
Cdd:smart01002  22 KVVVIGAGVVGLGAAATAKGLGAEVTV-----LDVRPARLRQLEslLGARFTTlysQAELLEEAVKEADLVIGAVLIP 94
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 7-453 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 560.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   7 YENKKVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENpEAQELLSLGIKVITGSHPIELLDEeFSLMVKNPGIPYSH 86
Cdd:COG0771    2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPEL-AAAELEAPGVEVVLGEHPEELLDG-ADLVVKSPGIPPDH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  87 PLVAKAQEMGIPVITEVELAYEVAECPIIgitgtngk-tttttmtgLLLNAGADqgiARLAGNIGYPASGVAQEAKSEDK 165
Cdd:COG0771   80 PLLKAARAAGIPVIGEIELAYRLSPAPIIaitgtngktttttlighILKAAGLR---VAVGGNIGTPLLDLLLEPEPPDV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 166 IVMELSSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPF 245
Cdd:COG0771  157 YVLELSSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 246 STKEVLEDGVYADDYSIYYKK--EKIMEISELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEI 323
Cdd:COG0771  237 SLKEPLEGGAGLEDGKLVDRAsgEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEI 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 324 QGRKFYNDSKATNILATKMALSGFEtSKVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIEtIVT 402
Cdd:COG0771  317 NGVRFINDSKATNPDATLAALESFD-GPVVLIAGGLDKGADFSPLAPAVAErVKAVVLIGEDAEKIAAALAGAGVP-VVI 394

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488215430 403 ADSVEQAVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNRLK 453
Cdd:COG0771  395 VETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVRELA 445
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 7-452 6.58e-139

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 405.89  E-value: 6.58e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   7 YENKKVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENPEAQELLS-LGIKVITGSHPIELLDEeFSLMVKNPGIPYS 85
Cdd:PRK14106   3 LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQLKEALEELGeLGIELVLGEYPEEFLEG-VDLVVVSPGVPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  86 HPLVAKAQEMGIPVITEVELAYEVAECPIIGITGTNGKTTTTTMT-GLLLNAGADQGIArlaGNIGYPASGVAQEAKSED 164
Cdd:PRK14106  82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLgEIFKNAGRKTLVA---GNIGYPLIDAVEEYGEDD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 165 KIVMELSSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLP 244
Cdd:PRK14106 159 IIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVIF 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 245 FSTKEVLEDGVYADDYSIYY----KKEKIMEISELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYV 320
Cdd:PRK14106 239 FSRKSLLEEGVFVKNGKIVIslggKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFV 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 321 GEIQGRKFYNDSKATNILATKMALSGFETSkVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIET 399
Cdd:PRK14106 319 AEINGVKFINDSKGTNPDAAIKALEAYETP-IVLIAGGYDKGSDFDEFAKAFKEkVKKLILLGETAQEIAEAARKYGFDN 397

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488215430 400 IVTADSVEQAVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNRL 452
Cdd:PRK14106 398 ILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 11-451 1.66e-130

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 384.00  E-value: 1.66e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   11 KVLVLGLAKSGVSAAKLLHELGALVTVNDGKPFDENPEAQELLSLGIKVITGSHPIELLDEEFSLMVKNPGIPYSHPLVA 90
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEELEPSMGQLRLNEGSVLHTGLHLEDLNNADLVVKSPGIPPDHPLVQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   91 KAQEMGIPVITEVELAYEVAECPIIGITGTNGKTTTTTMTGLLLNAGADQgiARLAGNIGYPASGVAQEAKSeDKIVMEL 170
Cdd:TIGR01087  81 AAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLK--AFLGGNIGTPALEVLDQEGA-ELYVLEL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  171 SSFQLMGITDFRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPFSTKEV 250
Cdd:TIGR01087 158 SSFQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  251 LEDGVYADDysiyyKKEKIMEISELG-VPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEIQGRKFY 329
Cdd:TIGR01087 238 AERGLCIRD-----GGLYLKPNDLEGsLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  330 NDSKATNILATKMALSGFETsKVVLLAGGLDRGNTFDELIPSLKG-IKAMVVFGQTKEKLMDAGKKAGIETIVtADSVEQ 408
Cdd:TIGR01087 313 NDSKATNVHATLAALSAFDN-PVILIVGGDDKGADFSPLAPAAAGkVKAVLAIGEDAAKIAPLLKEAGLSVYL-VESLEE 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 488215430  409 AVPLALENSTDGDVVLLSPANASWDQYPNFETRGNRFMEAVNR 451
Cdd:TIGR01087 391 AVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVRA 433
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 20-424 4.55e-32

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 127.10  E-value: 4.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  20 SGVSA-AKLLHELGALVTVNDGKpfdENPEAQELLSLGIKVITGsHPIELLDEEfSLMVKNPGIPYSHPLVAKAQEMGIP 98
Cdd:COG0773   15 IGMSGlAEILLALGYKVSGSDLA---ESPMTERLEALGIPVFIG-HDAENIDDA-DLVVVSSAIPRDNPELVAARERGIP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  99 VITEVELAYE----------------------VAecpiigitgtngktttttmtGLLLNAGADQGIArlagnIGypasGV 156
Cdd:COG0773   90 VLSRAEMLAElmrgkrsiavagthgkttttsmLA--------------------HILEEAGLDPTFL-----IG----GI 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 157 AQEAKS------EDKIVME----LSSFQLmgitdFRPHIAVITNIyEA-HIDYHGTRKEYVKAKWNLQKNMTEKDYLILN 225
Cdd:COG0773  141 LNNFGTnarlgdGDYFVAEadesDGSFLH-----YSPDIAVVTNI-EAdHLDIYGDLEAIKEAFHEFARNVPFYGLLVLC 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 226 WNQSELQELAQRTKARVLPFSTKEvlEDGVYADDYS---------IYYKKEKIMEIsELGVPGKHNVENALAAISVAKLY 296
Cdd:COG0773  215 ADDPGLRELLPRCGRPVITYGFSE--DADYRAENIRidgggstfdVLRRGEELGEV-ELNLPGRHNVLNALAAIAVALEL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 297 GISNEAIRETLHFFHGVPHRTQYVGEIQGRKFYND-----SKatnILAT-KMALSGFETSKVVL-----LaggldrgNT- 364
Cdd:COG0773  292 GVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDDyahhpTE---IAATlAAAREKYPDRRLVAvfqphR-------YSr 361

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488215430 365 ----FDELIPSLKGIKAMVVF-----------GQTKEKLMDAGKKAGIETIVtADSVEQAVPLALENSTDGDVVL 424
Cdd:COG0773  362 trdfLDEFAEALSLADEVILLdiyaarekpipGVSSEDLAEAIRKRGKDVVY-VPDLDELVEALAEIARPGDVVL 435
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 182-425 1.62e-27

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 114.04  E-value: 1.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 182 RPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPFSTKEvlEDGVYADDYS 261
Cdd:COG0770  175 RPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKARVLTFGLSE--DADVRAEDIE 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 262 ---------IYYKKEKImEIsELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEIQGRKFYNDS 332
Cdd:COG0770  253 ldedgtrftLHTPGGEL-EV-TLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDS 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 333 -KAtNILATKMALSGFET-----SKVVLLAG----GLDRGNTFDELIPSLK--GIKAMVVFGqtkEKLMDAGKKAGIETI 400
Cdd:COG0770  331 yNA-NPDSMKAALDVLAQlpgggRRIAVLGDmlelGEESEELHREVGELAAelGIDRLFTVG---ELARAIAEAAGGERA 406

                        250       260
                 ....*....|....*....|....*
gi 488215430 401 VTADSVEQAVPLALENSTDGDVVLL 425
Cdd:COG0770  407 EHFEDKEELLAALKALLRPGDVVLV 431
Mur_ligase_M pfam08245
Mur ligase middle domain;
149-293 1.20e-25

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 103.54  E-value: 1.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  149 IGYPASgVAQEAKSE-DKIVMELSSF-----QLMGITdfRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYL 222
Cdd:pfam08245  43 IGLPLT-LAEMVEAGaEYAVLEVSSHglgegRLSGLL--KPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  223 ILNW---NQSELQELAQRTKARVLPFSTKEvlEDGVYADD---------YSIYYKKEKIMEIsELGVPGKHNVENALAAI 290
Cdd:pfam08245 120 VINAddpYGAFLIAKLKKAGVRVITYGIEG--EADLRAANielssdgtsFDLFTVPGGELEI-EIPLLGRHNVYNALAAI 196


                  ...
gi 488215430  291 SVA 293
Cdd:pfam08245 197 AAA 199
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 15-354 5.15e-22

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 98.15  E-value: 5.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   15 LGLAKSGVSA-AKLLHELGALVTVNDGKpfdENPEAQELLSLGIKVITGsHPIELLDEeFSLMVKNPGIPYSHPLVAKAQ 93
Cdd:TIGR01082   5 VGIGGIGMSGiAEILLNRGYQVSGSDIA---ENATTKRLEALGIPIYIG-HSAENLDD-ADVVVVSAAIKDDNPEIVEAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430   94 EMGIPVITEVELAYEV--AECPIIGITGTNGKTTTTTMTGLLLNAGADQGIArLAGNIGypASGVAQEAKSEDKIVMEL- 170
Cdd:TIGR01082  80 ERGIPVIRRAEMLAELmrFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVV-VGGLVK--EAGTNARLGSGEYLVAEAd 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  171 ---SSFqlmgiTDFRPHIAVITNIYEAHIDYHGTRKEYVKAKW-----NLQKNmtekDYLILNWNQSELQELAQRTKARV 242
Cdd:TIGR01082 157 esdASF-----LHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFekfihNLPFY----GLAVICADDPVLRELVPKATEQV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  243 ----LPFSTKEVLEDGVYADDYSIYY---KKEKIMEISELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPH 315
Cdd:TIGR01082 228 itygGSGEDADYRAENIQQSGAEGKFsvrGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKR 307

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 488215430  316 RTQYVGEIQGRKFYND--SKATNILAT-KMALSGFETSKVVL 354
Cdd:TIGR01082 308 RFEILGEFGGVLLIDDyaHHPTEIKATlKAARQGYPDKRIVV 349
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 167-331 2.15e-20

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 93.22  E-value: 2.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 167 VMELSSfqlMGI-------TDFrpHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTK 239
Cdd:COG0769  152 VMEVSS---HALdqgrvdgVRF--DVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAP 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 240 ARVLPFSTKEvlEDGVYADD---------YSIYYKkEKIMEIsELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFF 310
Cdd:COG0769  227 ARVITYGLKA--DADLRATDielsadgtrFTLVTP-GGEVEV-RLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKL 302

                        170       180
                 ....*....|....*....|.
gi 488215430 311 HGVPHRTQYVGEIQGRKFYND 331
Cdd:COG0769  303 KGVPGRMERVDGGQGPTVIVD 323
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 148-355 3.96e-15

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 76.92  E-value: 3.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  148 NIGYPASgVAQEAKSEDKIVMELS-SFQ-----LMGITdfRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDY 221
Cdd:TIGR01143 112 EIGLPLT-LLRAPGDHDYAVLEMGaSHPgeiayLAEIA--KPDIAVITNIGPAHLEGFGSLEGIAEAKGEILQGLKENGI 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  222 LILNWNQSELQELAQRTKAR-VLPFS-------TKEVLEDGVYADDYSIYYKKEKImEISeLGVPGKHNVENALAAISVA 293
Cdd:TIGR01143 189 AVINADDPAFADLAKRLPNRnILSFGfeggdfvAKDISYSALGSTSFTLVAPGGEF-EVS-LPLLGRHNVMNALAAAALA 266

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488215430  294 KLYGISNEAIRETLHFFHGVPHRTQYVgEIQGRKFYNDSKATN---ILATKMALSGFETSKVVLL 355
Cdd:TIGR01143 267 LELGIPLEEIAEGLAELKLVKGRFEVQ-TKNGLTLIDDTYNANpdsMRAALDALARFPGKKILVL 330
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 167-425 1.41e-14

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 75.43  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  167 VMELSSFQL----MGITDFRphIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKARV 242
Cdd:TIGR01085 160 VMEVSSHALaqgrVRGVRFD--AAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLPKDI 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  243 lpFSTKEVLEDGVYADDYSI---------------YYKKEKIMEISelgVPGKHNVENALAAISVAKLYG-ISNEAIRET 306
Cdd:TIGR01085 238 --TVSAITQPADGRAQDIKItdsgysfegqqftfeTPAGEGHLHTP---LIGRFNVYNLLAALATLLHLGgIDLEDIVAA 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430  307 LHFFHGVPHRTQYVGEIQGRKFYNDSKAT-----NILATKMALSGFETSKVVLLAGGLDRGNTF----------DELI-- 369
Cdd:TIGR01085 313 LEKFRGVPGRMELVDGGQKFLVIVDYAHTpdaleKALRTLRKHKDGRLIVVFGCGGDRDRGKRPlmgaiaeqlaDLVIlt 392

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488215430  370 ---P---SLKGIKAMVVfgqtkeklmdAGKKAGIETIVTADSvEQAVPLALENSTDGDVVLL 425
Cdd:TIGR01085 393 sdnPrgeDPEQIIADIL----------AGISEKEKVVIIADR-RQAIRYAISNAKAGDVVLI 443
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 182-446 1.90e-12

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 69.35  E-value: 1.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 182 RPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQE-LAQRTKARVLPFSTKEVLEdgVYADDY 260
Cdd:PRK11929 681 APTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIwAKLAGARRVLRFGLQPGAD--VYAEKI 758

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 261 ----------SIYYKKEKIMEISELGVP--GKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEIQGRKF 328
Cdd:PRK11929 759 akdisvgeagGTRCQVVTPAGSAEVYLPliGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRI 838

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 329 YNDSKATNILATKMALSGFET----SKVVLLAGGLDRGNTFDEL---IPSL---KGIKAMVVFGqtkEKLMDAGKKAGIE 398
Cdd:PRK11929 839 IDDTYNANPDSMRAAIDVLAElpngPRALVLGDMLELGDNGPAMhreVGKYarqLGIDALITLG---EAARDAAAAFGAG 915

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488215430 399 TIVTADSVEQAVPLALENSTDGDVVLLspanaswdqypnfetRGNRFM 446
Cdd:PRK11929 916 ARGVCASVDEIIAALRGALPEGDSVLI---------------KGSRFM 948
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 167-325 3.31e-11

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 64.77  E-value: 3.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 167 VMELSS-----FQLMGiTDFRphIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKdyLILNWNQSELQELAQRTKAR 241
Cdd:PRK00139 167 AMEVSShaldqGRVDG-LKFD--VAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLA--AVINADDEVGRRLLALPDAY 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 242 VLPFStkevlEDGVYADDYSIYYKKEKIMEISELGVP--GKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQY 319
Cdd:PRK00139 242 AVSMA-----GADLRATDVEYTDSGQTFTLVTEVESPliGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMER 316


                 ....*.
gi 488215430 320 VGEIQG 325
Cdd:PRK00139 317 VDAGQG 322
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 164-326 3.62e-11

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 65.50  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 164 DKIVMELSSFQL-MGITD-FRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKAR 241
Cdd:PRK11929 181 DAVAMEASSHGLeQGRLDgLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALPRG 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 242 VLPFSTKEVLEDGVYADDYSIYYKKEkIMEIS--------ELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGV 313
Cdd:PRK11929 261 LKVGYSPQNAGADVQARDLRATAHGQ-VFTLAtpdgsyqlVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPV 339

                        170
                 ....*....|...
gi 488215430 314 PHRTQYVGEIQGR 326
Cdd:PRK11929 340 PGRMERVGPTAGA 352
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
178-318 6.48e-11

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 64.45  E-value: 6.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 178 ITDFRPHIAVITNIYEAHIDYHGTRKEYVKAkwNLQKNMTEKDYLILNWNQSELQELAQRTKARVLPFSTKEVLEDGVYA 257
Cdd:PRK14573 166 LKHYTPEFSVITNIDNEHLSNFEGDRELLLA--SIQDFARKVQQINKCFYNGDCPRLKGCLQGHSYGFSSSCDLHILSYY 243

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488215430 258 DD-----YSIYYKKEKIMEIsELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQ 318
Cdd:PRK14573 244 QEgwrsyFSAKFLGVVYQDI-ELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLE 308
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 313-381 1.80e-10

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 57.35  E-value: 1.80e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215430  313 VPHRTQYVGEIQGRKFYNDsKATNILATKMALSGFET---SKVVLLAGG-LDRGNTFDELIPSLKGIKAMVVF 381
Cdd:pfam02875   1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNlfpGRLILVFGGmGDRDAEFHALLGRLAAALADVVI 72
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 182-311 1.13e-06

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 50.93  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 182 RPHIAVITNIYEAH--IDYHGTRKE--YVKAkwnLQKNMTEKD-YLILNWNQSELQELAQRTKARVLPFST-------KE 249
Cdd:PRK14016 565 RCDVGVVTNIGEDHlgLGGINTLEDlaKVKR---VVVEAVKPDgYAVLNADDPMVAAMAERCKGKVIFFSMdpdnpviAE 641

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215430 250 VLEDG---VYADDYSIYY----KKEKIMEISELGV--PGK--HNVENALAAISVAKLYGISNEAIRETLHFFH 311
Cdd:PRK14016 642 HRAQGgraVYVEGDYIVLaeggWEIRIISLADIPLtlGGKagFNIENALAAIAAAWALGIDIELIRAGLRTFV 714
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 182-316 2.74e-05

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 46.18  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 182 RPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILN--------WNQSelqeLAQRTKARvlpFSTKEVLED 253
Cdd:PRK10773 175 RPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNadsndwlnWQSV----IGSKTVWR---FSPNAANSV 247

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215430 254 GVYADDYSIyykKEKIMEIS----------ELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHR 316
Cdd:PRK10773 248 DFTATNIHV---TSHGTEFTlhtptgsvdvLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGR 317
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 182-297 5.29e-05

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 45.54  E-value: 5.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 182 RPHIAVITNIYEAHIDYHGTRKEYVKAKWNLQKNMTEKDYLILNWNQSELQELAQRTKA----RVLPFSTKEVLE----- 252
Cdd:PRK14093 183 RPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAagiaRIVSFGADEKADarlld 262

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488215430 253 -------DGVYAD--DYSIYYKkekimeiseLGVPGKHNVENALAAISVAKLYG 297
Cdd:PRK14093 263 valhadcSAVHADilGHDVTYK---------LGMPGRHIAMNSLAVLAAAELAG 307
AlaDh_PNT_C smart01002
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...
 11-83 1.00e-03

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.


Pssm-ID: 214966 [Multi-domain]  Cd Length: 149  Bit Score: 39.41  E-value: 1.00e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488215430    11 KVLVLGLAKSGVSAAKLLHELGALVTVndgkpFDENPEAQELLS--LGIKVIT---GSHPIELLDEEFSLMVKNPGIP 83
Cdd:smart01002  22 KVVVIGAGVVGLGAAATAKGLGAEVTV-----LDVRPARLRQLEslLGARFTTlysQAELLEEAVKEADLVIGAVLIP 94
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
 181-368 7.29e-03

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 38.79  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 181 FRPHIAVITNIYEAHIDYHGTRKEYVKAKWNLqknMTEKDYLILNWNQSELQELAQRT--KARVLPFSTK--------EV 250
Cdd:PRK11930 181 IKPTIGILTNIGGAHQENFRSIKQKIMEKLKL---FKDCDVIIYNGDNELISSCITKSnlTLKLISWSRKdpeaplyiPF 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215430 251 LEDGVYADDYSIYYKKEKIMEisELGVPGKHNVENALAAISVAKLYGISNEAIRETLHFFHGVPHRTQYVGEIQGRKFYN 330
Cdd:PRK11930 258 VEKKEDHTVISYTYKGEDFHF--EIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEPVAMRLEVKEGINNCTLIN 335

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 488215430 331 DSKATNILATKMALSGFE-----TSKVVLLAGGLDRGNTFDEL 368
Cdd:PRK11930 336 DSYNSDLQSLDIALDFLNrrsqsKKKTLILSDILQSGQSPEEL 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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