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Conserved domains on  [gi|488223740|ref|WP_002294948|]
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MULTISPECIES: MurR/RpiR family transcriptional regulator [Enterococcus]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-271 1.60e-52

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 173.58  E-value: 1.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   1 MLLREKIKEI--SFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAFLAEtayLEGN 78
Cdd:COG1737    5 MSLLERIRARypSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQE---LAEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  79 FQDVDANLPFSTTDGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKM 158
Cdd:COG1737   82 LSSYERLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 159 DVTIVTTFGESFYE-AYNCTSDMCGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAALRLTTRERLYs 237
Cdd:COG1737  162 NVVLLDGDGHLQAEsAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTL- 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 488223740 238 KIGNFTINTSICYLLDVLYSCVFAENYQQNLVHL 271
Cdd:COG1737  241 RSSAFSSRVAQLALIDALAAAVAQRDGDKARERL 274
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-271 1.60e-52

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 173.58  E-value: 1.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   1 MLLREKIKEI--SFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAFLAEtayLEGN 78
Cdd:COG1737    5 MSLLERIRARypSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQE---LAEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  79 FQDVDANLPFSTTDGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKM 158
Cdd:COG1737   82 LSSYERLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 159 DVTIVTTFGESFYE-AYNCTSDMCGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAALRLTTRERLYs 237
Cdd:COG1737  162 NVVLLDGDGHLQAEsAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTL- 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 488223740 238 KIGNFTINTSICYLLDVLYSCVFAENYQQNLVHL 271
Cdd:COG1737  241 RSSAFSSRVAQLALIDALAAAVAQRDGDKARERL 274
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 119-258 7.58e-24

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 94.22  E-value: 7.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 119 DQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKMDVTIVTTFGESFYEAYNCTSDMCGILISYTGENNVILRTA 198
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 199 EILKQNHVPILALTSIGDSTLSSMSTAALRLTTRERLYsKIGNFTINTSICYLLDVLYSC 258
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDF-RSSAFSSRIAQLALIDALFLA 139
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
1-254 1.28e-17

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 80.90  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   1 MLLREKIK--EISFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAFLAETAYLEGN 78
Cdd:PRK15482   1 MLYLTKIRnaESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  79 FQDVDANLPFSTT--DGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRI 156
Cdd:PRK15482  81 TNATALHLHSSITsdDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 157 ------KMDVTIVTTFGESFYEAynctsDMcGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAALRLT 230
Cdd:PRK15482 161 gyrvacEADTHVQATVSQALKKG-----DV-QIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTV 234

                        250       260
                 ....*....|....*....|....*.
gi 488223740 231 TRERLY--SKIGNFTINTSICYLLDV 254
Cdd:PRK15482 235 SGETEWrsSSMSTRTAQNSVTDLLFV 260
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 127-233 5.97e-12

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 61.93  E-value: 5.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  127 LMLQAKKIVIFASNSNTLISQDFMLKMKRIKMDVTIVTTFGESFYE-AYNCTSDMCGILISYTGENNVILRTAEILKQNH 205
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGvLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100
                  ....*....|....*....|....*...
gi 488223740  206 VPILALTSIGDSTLSSMSTAALRLTTRE 233
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVLYINAGP 108
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-65 4.18e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 4.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 488223740    31 GEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFR 65
Cdd:smart00347  23 GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRRE 57
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-271 1.60e-52

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 173.58  E-value: 1.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   1 MLLREKIKEI--SFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAFLAEtayLEGN 78
Cdd:COG1737    5 MSLLERIRARypSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQE---LAEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  79 FQDVDANLPFSTTDGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKM 158
Cdd:COG1737   82 LSSYERLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 159 DVTIVTTFGESFYE-AYNCTSDMCGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAALRLTTRERLYs 237
Cdd:COG1737  162 NVVLLDGDGHLQAEsAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTL- 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 488223740 238 KIGNFTINTSICYLLDVLYSCVFAENYQQNLVHL 271
Cdd:COG1737  241 RSSAFSSRVAQLALIDALAAAVAQRDGDKARERL 274
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 119-258 7.58e-24

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 94.22  E-value: 7.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 119 DQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKMDVTIVTTFGESFYEAYNCTSDMCGILISYTGENNVILRTA 198
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 199 EILKQNHVPILALTSIGDSTLSSMSTAALRLTTRERLYsKIGNFTINTSICYLLDVLYSC 258
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDF-RSSAFSSRIAQLALIDALFLA 139
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
1-254 1.28e-17

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 80.90  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   1 MLLREKIK--EISFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAFLAETAYLEGN 78
Cdd:PRK15482   1 MLYLTKIRnaESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  79 FQDVDANLPFSTT--DGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRI 156
Cdd:PRK15482  81 TNATALHLHSSITsdDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 157 ------KMDVTIVTTFGESFYEAynctsDMcGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAALRLT 230
Cdd:PRK15482 161 gyrvacEADTHVQATVSQALKKG-----DV-QIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTV 234

                        250       260
                 ....*....|....*....|....*.
gi 488223740 231 TRERLY--SKIGNFTINTSICYLLDV 254
Cdd:PRK15482 235 SGETEWrsSSMSTRTAQNSVTDLLFV 260
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
6-266 5.47e-13

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 67.86  E-value: 5.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   6 KIKEISFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAflaetayLEGNFQDVDAN 85
Cdd:PRK11337  20 RMKQEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSA-------LEDYFSQSEQV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  86 LPF--STTDGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKMDVTIV 163
Cdd:PRK11337  93 LHSelSFDDAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 164 TTFGESFYEAYNCTSDMCGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSM------STAALRLTTRERLYS 237
Cdd:PRK11337 173 DDAHIMLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLadyvicSTAQGSPLLGENAAA 252

                        250       260
                 ....*....|....*....|....*....
gi 488223740 238 KIGNFTIntsicylLDVLYSCVFAENYQQ 266
Cdd:PRK11337 253 RIAQLNI-------LDAFFVSVAQLNIEQ 274
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
11-227 3.60e-12

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 65.17  E-value: 3.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  11 SFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRNAfLAETAYLEGNFQDVDANLPFST 90
Cdd:PRK11557   9 GLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLA-LSEALASQPEPPSVPVHNQIRG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  91 TDGIMTIANKMASLEQMTIQDTLSLIHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKMDVTIVTTFGESF 170
Cdd:PRK11557  88 DDPLRLVGEKLIKENTAAMRATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGINAVAERDMHALL 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488223740 171 YEAYNCTSDMCGILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAAL 227
Cdd:PRK11557 168 ATVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHCL 224
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 127-233 5.97e-12

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 61.93  E-value: 5.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  127 LMLQAKKIVIFASNSNTLISQDFMLKMKRIKMDVTIVTTFGESFYE-AYNCTSDMCGILISYTGENNVILRTAEILKQNH 205
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASELRHGvLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100
                  ....*....|....*....|....*...
gi 488223740  206 VPILALTSIGDSTLSSMSTAALRLTTRE 233
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVLYINAGP 108
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-233 2.05e-09

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 57.31  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   1 MLLREKIKE--ISFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRnAFLAE-----TA 73
Cdd:PRK11302   1 MNMLEKIQSrlEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFK-LHLAQslangTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  74 YLEGNFQDVDAnlPFSTTDGIMTIAnkMASLEqmTIQDTLSlihHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKM 153
Cdd:PRK11302  80 YVNRNVEEDDS--VEAYTGKIFESA--MASLD--HARQSLD---PSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKF 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 154 KRIKMDVTIVTTFGESFYEAYNCTSDMCGILISYTGENNVILRTAEILKQNHVPILALTSiGDSTLSSMSTAALRLTTRE 233
Cdd:PRK11302 151 FRFNVPVVYFDDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITS-AGSPLAREATLALTLDVPE 229
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
5-239 2.05e-07

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 52.23  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740   5 EKIKEI--SFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFRnafLAETAYLEGNFQdv 82
Cdd:PRK14101 345 ERIRQMrdALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFK---LKLATGLTGTIP-- 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740  83 DANLPFSTTDgimTIANKMASLEQMTIQDTLSL---IHHDQLQKAKQLMLQAKKIVIFASNSNTLISQDFMLKMKRIKMD 159
Cdd:PRK14101 420 MSHSQVHLGD---TATDFGAKVLDNTVSAILQLrehLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIP 496

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488223740 160 vtiVTTFGESFYEAynCTSDMCG-----ILISYTGENNVILRTAEILKQNHVPILALTSiGDSTLSSMSTAALRLTTRER 234
Cdd:PRK14101 497 ---TIAYGDLYMQA--ASAALLGkgdviVAVSKSGRAPELLRVLDVAMQAGAKVIAITS-SNTPLAKRATVALETDHIEM 570


                 ....*
gi 488223740 235 LYSKI 239
Cdd:PRK14101 571 RESQL 575
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-65 1.70e-06

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 45.01  E-value: 1.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488223740    1 MLLREKI--KEISFSPSENEVIQFLLSDSPALGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFR 65
Cdd:pfam01418   1 MGLLEKIqsRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELK 67
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 183-233 7.01e-04

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 40.73  E-value: 7.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488223740 183 ILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLSSMSTAALRLT-TRE 233
Cdd:COG0794   96 IAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLPvERE 147
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 183-220 1.07e-03

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 38.29  E-value: 1.07e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 488223740 183 ILISYTGENNVILRTAEILKQNHVPILALTSIGDSTLS 220
Cdd:cd05014   52 IAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLA 89
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-65 4.18e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 4.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 488223740    31 GEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFR 65
Cdd:smart00347  23 GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRRE 57
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-65 9.95e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.06  E-value: 9.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 488223740   30 LGEMTIQEIAERCYVHPSTLIRVAKKMGFDGWVSFR 65
Cdd:pfam01047  15 HGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERS 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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