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Conserved domains on  [gi|488242576|ref|WP_002313784|]
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MULTISPECIES: PTS sugar transporter subunit IIC [Enterococcus]

Protein Classification

PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC( domain architecture ID 10007905)

PTS mannose/fructose/sorbose/N-acetylgalactosamine-specific transporter subunit IIC is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates (such as mannose, fructose, sorbose, and N-acetylgalactosamine) concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
1-254 5.89e-89

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


:

Pssm-ID: 442929  Cd Length: 259  Bit Score: 264.29  E-value: 5.89e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   1 MLFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIAT 80
Cdd:COG3715    4 SLIQAILIGLVAFLAGIDG-LLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGIIGT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  81 AFAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIYGtVLYSLMYFIPIFLAVYF 160
Cdd:COG3715   83 ALAILSGQDPETAIALAVPVGLLGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGP-LLQFLLRAIPVFLALYF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576 161 GTDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQVK 240
Cdd:COG3715  162 GADAVQALLNAIPAWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLLAIAIIGVAIALIYYQLK 241
                        250
                 ....*....|....
gi 488242576 241 FNGKDNRTAVSEPD 254
Cdd:COG3715  242 KKKNAAAAAASGDD 255
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
1-254 5.89e-89

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 264.29  E-value: 5.89e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   1 MLFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIAT 80
Cdd:COG3715    4 SLIQAILIGLVAFLAGIDG-LLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGIIGT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  81 AFAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIYGtVLYSLMYFIPIFLAVYF 160
Cdd:COG3715   83 ALAILSGQDPETAIALAVPVGLLGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGP-LLQFLLRAIPVFLALYF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576 161 GTDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQVK 240
Cdd:COG3715  162 GADAVQALLNAIPAWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLLAIAIIGVAIALIYYQLK 241
                        250
                 ....*....|....
gi 488242576 241 FNGKDNRTAVSEPD 254
Cdd:COG3715  242 KKKNAAAAAASGDD 255
EII-Sor pfam03609
PTS system sorbose-specific iic component;
2-235 9.63e-85

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 252.33  E-value: 9.63e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576    2 LFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATA 81
Cdd:pfam03609   1 LIQAILIGLVAFLAGLDG-LLGQFTLHRPLVAGTLVGLILGDVQTGLIIGATLQLMYLGVVTIGGAVPPDAALAGIIGTA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   82 FAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIYGTVLYSLMYFIPIFLAVYFG 161
Cdd:pfam03609  80 LAILSGIGPEAAIALAVPVALLGQQLDNLVRTINSFFVHKADKYAEEGNYKGIERIHLLGPQLLGLLIRFIPVFLALYFG 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488242576  162 TDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFV 235
Cdd:pfam03609 160 ADAVQALLNAIPEWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
10-258 1.55e-48

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 161.16  E-value: 1.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  10 LVGIMCILDSRllgrmNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATAFAILSGSN 89
Cdd:PRK15065  17 IAGMESILDEF-----QFHRPLVACTLIGLVLGDLKTGIILGGTLEMIALGWMNIGAAVAPDAALASVISAILVIAGHQG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  90 AETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIyGTVLYSLMYFIP-IFLAVYFGTDLVKNI 168
Cdd:PRK15065  92 IGTGIAIAIPLAAAGQVLTIIVRTITVAFQHAADKAAEEGNFRAIEWLHVS-ALLLQALRIAIPaALVALAVGTSAVQSM 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576 169 VSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQV--KFNGKDN 246
Cdd:PRK15065 171 LNAIPEVLTGGLNIGGGMIVVVGYAMVINMMATRELMPFFYLGFVLAAFTNLNLIALGVIGVVLALIYLQLspKYGRVAG 250
                        250
                 ....*....|..
gi 488242576 247 RTAVSEPDPLDD 258
Cdd:PRK15065 251 GGAAGSGDPLDD 262
EII-Sor TIGR00822
PTS system, mannose/fructose/sorbose family, IIC component; Bacterial PTS transporters ...
2-249 9.56e-47

PTS system, mannose/fructose/sorbose family, IIC component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Man (PTS splinter group) family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine,N-acetylglucosamine, and other sugars. Other members of this family can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the sorbose-specific IIC subunits of this family of PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129902  Cd Length: 265  Bit Score: 156.50  E-value: 9.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576    2 LFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATA 81
Cdd:TIGR00822   5 TLQIILLFILACIAGIGS-VLDEFQTHRPLIACTLVGLILGDLKTGIILGGTLELIALGWMNVGAAQAPDPALASIISTI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   82 FAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIyGTVLYSLMYFIPIFLAVYFG 161
Cdd:TIGR00822  84 LVISGHQSIGTGIALALPLAAAGQVLTIFVRTITVLFQHAADKAAKEANTAAISRLHVT-AMLIQALRVAIPALIVALVS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  162 TDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQvkF 241
Cdd:TIGR00822 163 QSAVQAMLKAIPEVVTHGLQIAGGIIVVVGYAMVLRMMFKAYLMPFFYLGFLFAAYTDFSLLAFGAVGGAGALLYIQ--L 240

                  ....*...
gi 488242576  242 NGKDNRTA 249
Cdd:TIGR00822 241 NPKSHRAQ 248
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
1-254 5.89e-89

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 264.29  E-value: 5.89e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   1 MLFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIAT 80
Cdd:COG3715    4 SLIQAILIGLVAFLAGIDG-LLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGIIGT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  81 AFAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIYGtVLYSLMYFIPIFLAVYF 160
Cdd:COG3715   83 ALAILSGQDPETAIALAVPVGLLGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGP-LLQFLLRAIPVFLALYF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576 161 GTDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQVK 240
Cdd:COG3715  162 GADAVQALLNAIPAWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLLAIAIIGVAIALIYYQLK 241
                        250
                 ....*....|....
gi 488242576 241 FNGKDNRTAVSEPD 254
Cdd:COG3715  242 KKKNAAAAAASGDD 255
EII-Sor pfam03609
PTS system sorbose-specific iic component;
2-235 9.63e-85

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 252.33  E-value: 9.63e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576    2 LFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATA 81
Cdd:pfam03609   1 LIQAILIGLVAFLAGLDG-LLGQFTLHRPLVAGTLVGLILGDVQTGLIIGATLQLMYLGVVTIGGAVPPDAALAGIIGTA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   82 FAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIYGTVLYSLMYFIPIFLAVYFG 161
Cdd:pfam03609  80 LAILSGIGPEAAIALAVPVALLGQQLDNLVRTINSFFVHKADKYAEEGNYKGIERIHLLGPQLLGLLIRFIPVFLALYFG 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488242576  162 TDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFV 235
Cdd:pfam03609 160 ADAVQALLNAIPEWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVLAAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
10-258 1.55e-48

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 161.16  E-value: 1.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  10 LVGIMCILDSRllgrmNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATAFAILSGSN 89
Cdd:PRK15065  17 IAGMESILDEF-----QFHRPLVACTLIGLVLGDLKTGIILGGTLEMIALGWMNIGAAVAPDAALASVISAILVIAGHQG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  90 AETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIyGTVLYSLMYFIP-IFLAVYFGTDLVKNI 168
Cdd:PRK15065  92 IGTGIAIAIPLAAAGQVLTIIVRTITVAFQHAADKAAEEGNFRAIEWLHVS-ALLLQALRIAIPaALVALAVGTSAVQSM 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576 169 VSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQV--KFNGKDN 246
Cdd:PRK15065 171 LNAIPEVLTGGLNIGGGMIVVVGYAMVINMMATRELMPFFYLGFVLAAFTNLNLIALGVIGVVLALIYLQLspKYGRVAG 250
                        250
                 ....*....|..
gi 488242576 247 RTAVSEPDPLDD 258
Cdd:PRK15065 251 GGAAGSGDPLDD 262
EII-Sor TIGR00822
PTS system, mannose/fructose/sorbose family, IIC component; Bacterial PTS transporters ...
2-249 9.56e-47

PTS system, mannose/fructose/sorbose family, IIC component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Man (PTS splinter group) family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine,N-acetylglucosamine, and other sugars. Other members of this family can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the sorbose-specific IIC subunits of this family of PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129902  Cd Length: 265  Bit Score: 156.50  E-value: 9.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576    2 LFQSIALGLVGIMCILDSrLLGRMNFERPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATA 81
Cdd:TIGR00822   5 TLQIILLFILACIAGIGS-VLDEFQTHRPLIACTLVGLILGDLKTGIILGGTLELIALGWMNVGAAQAPDPALASIISTI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   82 FAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIyGTVLYSLMYFIPIFLAVYFG 161
Cdd:TIGR00822  84 LVISGHQSIGTGIALALPLAAAGQVLTIFVRTITVLFQHAADKAAKEANTAAISRLHVT-AMLIQALRVAIPALIVALVS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  162 TDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYSGLSITGIAAFACIVAFVMAQvkF 241
Cdd:TIGR00822 163 QSAVQAMLKAIPEVVTHGLQIAGGIIVVVGYAMVLRMMFKAYLMPFFYLGFLFAAYTDFSLLAFGAVGGAGALLYIQ--L 240

                  ....*...
gi 488242576  242 NGKDNRTA 249
Cdd:TIGR00822 241 NPKSHRAQ 248
PRK09757 PRK09757
PTS N-acetylgalactosamine transporter subunit IIC;
2-253 7.42e-32

PTS N-acetylgalactosamine transporter subunit IIC;


Pssm-ID: 236621  Cd Length: 267  Bit Score: 118.02  E-value: 7.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576   2 LFQSIALGLVGIMCILDSRLLGRMNFeRPLIVSTLVGLVLGDLEKGLLVGASLELMSLGLVNIGAAAPPDMNMASIIATA 81
Cdd:PRK09757   6 LLQGLSLAALVFVLGIDFWLEALFLF-RPIIVCTLTGAILGDIQTGLITGGLTELAFAGLTPAGGVQPPNPIMAGLMTTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576  82 FAILSGSNAETALTIAIPISVLGQMLGILMRTVLSNLTHWADNLINEGKFSRARRIHIIyGTVLYSLMYFIPIFLAVYFG 161
Cdd:PRK09757  85 IAWSTGVDAKTAIGLGLPFSLLMQYVILFFYSAFSLFMTKADKCAKEADTAAFSRLNWT-TMLIVASAYAVIAFLCTYLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488242576 162 TDLVKNIVSSIPVWLTNGLTLASKILPAYGFALLLQTMLTKKMIPFLLLGFLITAYsgLSITGIAAFACIVAFVMAQVKF 241
Cdd:PRK09757 164 QGAMQALVKAMPAWLTHGFEVAGGILPAVGFGLLLRVMFKAQYIPYLIAGFLFVCY--IQVSNLLPVAVLGAGFAVYEFF 241
                        250
                 ....*....|..
gi 488242576 242 NGKDNRTAVSEP 253
Cdd:PRK09757 242 NAKSRQQAQPQP 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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