|
Name |
Accession |
Description |
Interval |
E-value |
| DeoA |
COG0213 |
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part ... |
3-431 |
0e+00 |
|
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439983 [Multi-domain] Cd Length: 431 Bit Score: 781.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 3 MVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIKVDKH 82
Cdd:COG0213 1 AVDIIRKKRDGGELTAEEIRFFIDGYTDGSIPDYQMAAFLMAVYFRGMTDEETAALTLAMRDSGDVLDLSDIPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 83 STGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLAPADK 162
Cdd:COG0213 81 STGGVGDKTSLVLAPLVAACGVPVPKMSGRGLGHTGGTLDKLESIPGFRTELSEEEFRRQVNEIGCAIIGQTGDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 163 KLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISDMSQP 242
Cdd:COG0213 161 KLYALRDVTATVESIPLIASSIMSKKLAAGADALVLDVKVGSGAFMKTLEDARELAESMVDIGNGAGRKTVALITDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 243 LGEAIGNSLEIVEAIETLQGNGPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQGGDSSV 322
Cdd:COG0213 241 LGRAVGNALEVKEAIETLKGEGPEDLTELTLALGAEMLVLAGLAKDLEEARAKLEEALASGKALEKFKEMVAAQGGDPDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 323 VDQPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANRE 402
Cdd:COG0213 321 VDDPELLPQAPVVREVKAPRSGYVSAIDARAIGLAAVLLGAGRATKEDPIDPAVGIVLLKKVGDKVEKGEPLATIHANDE 400
|
410 420 430
....*....|....*....|....*....|.
gi 488284957 403 -DVTEVEQLLYKNIEIGPTGEEPI-LIHDII 431
Cdd:COG0213 401 aDAEEAAERLRAAYTIGDEPPEPPpLIYERI 431
|
|
| PRK06078 |
PRK06078 |
pyrimidine-nucleoside phosphorylase; Reviewed |
1-433 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; Reviewed
Pssm-ID: 180387 [Multi-domain] Cd Length: 434 Bit Score: 730.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 1 MRMVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIKVD 80
Cdd:PRK06078 1 MRMVDLIQKKRDGKELTTEEINFFIEGYTNGTIPDYQMSALAMAIYFKDMTDRERADLTMAMVNSGDTIDLSAIEGIKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 81 KHSTGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLAPA 160
Cdd:PRK06078 81 KHSTGGVGDTTTLVLAPLVAAFGVPVAKMSGRGLGHTGGTIDKLESIKGFHVEISQEDFIKLVNENKVAVIGQSGNLTPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 161 DKKLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISDMS 240
Cdd:PRK06078 161 DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTVEDAEELAHAMVRIGNNVGRNTMAVISDMS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 241 QPLGEAIGNSLEIVEAIETLQGNGPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQGGDS 320
Cdd:PRK06078 241 QPLGRAIGNALEVLEAIDTLQGKGPKDLTELVLTLGSQMVVLAGKAKTLEEAREHLIEVMNNGKALEKFKEFLSAQGGDA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 321 SVVDQPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYAN 400
Cdd:PRK06078 321 SVVDDPEKLPQAKYQIEVPAKESGYISELVADEIGLAAMLLGAGRATKEDEIDLAVGIVLRKKVGDSVKKGESLATIYAN 400
|
410 420 430
....*....|....*....|....*....|....
gi 488284957 401 REDVTEVEQLLYKNIEIGP-TGEEPILIHDIITE 433
Cdd:PRK06078 401 RENVEDVKAKFYKNIKISKeHVVAPELIHIIITE 434
|
|
| Y_phosphoryl |
TIGR02644 |
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated ... |
3-403 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274244 [Multi-domain] Cd Length: 405 Bit Score: 627.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 3 MVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIKVDKH 82
Cdd:TIGR02644 1 AVDIIRKKRDGKKLSDEEINFFINGYTNGEIPDYQMSALLMAIYFNGMTDEETAYLTKAMIDSGEVLDLSSLPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 83 STGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLAPADK 162
Cdd:TIGR02644 81 STGGVGDKVSLVLGPIVAACGVKVAKMSGRGLGHTGGTIDKLESIPGFRTELSEAEFIEIVNKVGLAIIGQTKDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 163 KLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISDMSQP 242
Cdd:TIGR02644 161 KLYALRDVTGTVDSIPLIASSIMSKKLAAGADAIVLDVKVGSGAFMKTLEDAKELAKLMVEIGKGAGRKTSALLTDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 243 LGEAIGNSLEIVEAIETLQGNGPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQGGDSSV 322
Cdd:TIGR02644 241 LGRAIGNALEVKEAVEFLKGEGPADLKELTLALAAEMLLLAGIAKTEKEARALAEDVLESGKALEKFRRFVEAQGGDPDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 323 VDQPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANRE 402
Cdd:TIGR02644 321 IKNLDKLPKAKYKEEVKAEKSGYISEIDAEELGLAAVDLGAGRARKEDKIDHEAGIYLHKKTGDRVKKGDPLATLYSSDP 400
|
.
gi 488284957 403 D 403
Cdd:TIGR02644 401 I 401
|
|
| Glycos_transf_3 |
pfam00591 |
Glycosyl transferase family, a/b domain; This family includes anthranilate ... |
75-306 |
6.01e-54 |
|
Glycosyl transferase family, a/b domain; This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate.
Pssm-ID: 459860 [Multi-domain] Cd Length: 253 Bit Score: 180.18 E-value: 6.01e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 75 EGIKVDKHSTGGVGDTT---TLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIpGFKVELTEERFIQLVNDTKVAVI 151
Cdd:pfam00591 1 LGDLVDIVGTGGDGDNTfniSTAAAIVAAACGVKVAKHGNRSVSSKSGSADVLEAL-GINLDLTPEQVRKLLDEVGVGFL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 152 GQSGDLAPADKKLYALRDVTA-TVDSI--PLIAS--------SIMSKKIAAGADAIVLDVTTGEGAFMK----DLASArr 216
Cdd:pfam00591 80 FAPNYHPAMKHVAPVRRELGIrTVFNLlgPLINParvkrqvlGVYSKELAEGLAEVLKDLGRERAAVVHgdglDEASL-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 217 LAETMVRIGKlANRQTMAVISDMSQPLGEAIGNSLEIV---EAIETLQG--NGPEDLVEMCYVL--GSQMVVLAKKAETL 289
Cdd:pfam00591 158 LGKTTVAELK-DGEITEYTLTPEDFGLGRATLEALEGGspkENADILKGvlGGKGSAAHRDLVAlnAGAALYLAGKADSL 236
|
250
....*....|....*..
gi 488284957 290 DEARALLEEALTSGRAL 306
Cdd:pfam00591 237 KEGVAKALEVIDSGKAL 253
|
|
| PYNP_C |
smart00941 |
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal ... |
345-418 |
3.64e-24 |
|
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Pssm-ID: 214925 [Multi-domain] Cd Length: 75 Bit Score: 94.91 E-value: 3.64e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488284957 345 VVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANREDVTE-VEQLLYKNIEIG 418
Cdd:smart00941 1 YVTAIDARALGLAAVLLGAGRARKEDPIDYGVGIVLHKKLGDRVKKGEPLATIHANDEAELEeAAEALRAAITIS 75
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DeoA |
COG0213 |
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part ... |
3-431 |
0e+00 |
|
Thymidine phosphorylase [Nucleotide transport and metabolism]; Thymidine phosphorylase is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439983 [Multi-domain] Cd Length: 431 Bit Score: 781.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 3 MVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIKVDKH 82
Cdd:COG0213 1 AVDIIRKKRDGGELTAEEIRFFIDGYTDGSIPDYQMAAFLMAVYFRGMTDEETAALTLAMRDSGDVLDLSDIPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 83 STGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLAPADK 162
Cdd:COG0213 81 STGGVGDKTSLVLAPLVAACGVPVPKMSGRGLGHTGGTLDKLESIPGFRTELSEEEFRRQVNEIGCAIIGQTGDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 163 KLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISDMSQP 242
Cdd:COG0213 161 KLYALRDVTATVESIPLIASSIMSKKLAAGADALVLDVKVGSGAFMKTLEDARELAESMVDIGNGAGRKTVALITDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 243 LGEAIGNSLEIVEAIETLQGNGPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQGGDSSV 322
Cdd:COG0213 241 LGRAVGNALEVKEAIETLKGEGPEDLTELTLALGAEMLVLAGLAKDLEEARAKLEEALASGKALEKFKEMVAAQGGDPDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 323 VDQPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANRE 402
Cdd:COG0213 321 VDDPELLPQAPVVREVKAPRSGYVSAIDARAIGLAAVLLGAGRATKEDPIDPAVGIVLLKKVGDKVEKGEPLATIHANDE 400
|
410 420 430
....*....|....*....|....*....|.
gi 488284957 403 -DVTEVEQLLYKNIEIGPTGEEPI-LIHDII 431
Cdd:COG0213 401 aDAEEAAERLRAAYTIGDEPPEPPpLIYERI 431
|
|
| PRK06078 |
PRK06078 |
pyrimidine-nucleoside phosphorylase; Reviewed |
1-433 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; Reviewed
Pssm-ID: 180387 [Multi-domain] Cd Length: 434 Bit Score: 730.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 1 MRMVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIKVD 80
Cdd:PRK06078 1 MRMVDLIQKKRDGKELTTEEINFFIEGYTNGTIPDYQMSALAMAIYFKDMTDRERADLTMAMVNSGDTIDLSAIEGIKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 81 KHSTGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLAPA 160
Cdd:PRK06078 81 KHSTGGVGDTTTLVLAPLVAAFGVPVAKMSGRGLGHTGGTIDKLESIKGFHVEISQEDFIKLVNENKVAVIGQSGNLTPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 161 DKKLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISDMS 240
Cdd:PRK06078 161 DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTVEDAEELAHAMVRIGNNVGRNTMAVISDMS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 241 QPLGEAIGNSLEIVEAIETLQGNGPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQGGDS 320
Cdd:PRK06078 241 QPLGRAIGNALEVLEAIDTLQGKGPKDLTELVLTLGSQMVVLAGKAKTLEEAREHLIEVMNNGKALEKFKEFLSAQGGDA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 321 SVVDQPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYAN 400
Cdd:PRK06078 321 SVVDDPEKLPQAKYQIEVPAKESGYISELVADEIGLAAMLLGAGRATKEDEIDLAVGIVLRKKVGDSVKKGESLATIYAN 400
|
410 420 430
....*....|....*....|....*....|....
gi 488284957 401 REDVTEVEQLLYKNIEIGP-TGEEPILIHDIITE 433
Cdd:PRK06078 401 RENVEDVKAKFYKNIKISKeHVVAPELIHIIITE 434
|
|
| Y_phosphoryl |
TIGR02644 |
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated ... |
3-403 |
0e+00 |
|
pyrimidine-nucleoside phosphorylase; In general, members of this protein family are designated pyrimidine-nucleoside phosphorylase, enzyme family EC 2.4.2.2, as in Bacillus subtilis, and more narrowly as the enzyme family EC 2.4.2.4, thymidine phosphorylase (alternate name: pyrimidine phosphorylase), as in Escherichia coli. The set of proteins encompassed by this model is designated subfamily rather than equivalog for this reason; the protein name from this model should be used when TIGR02643 does not score above trusted cutoff. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274244 [Multi-domain] Cd Length: 405 Bit Score: 627.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 3 MVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIKVDKH 82
Cdd:TIGR02644 1 AVDIIRKKRDGKKLSDEEINFFINGYTNGEIPDYQMSALLMAIYFNGMTDEETAYLTKAMIDSGEVLDLSSLPGPKVDKH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 83 STGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLAPADK 162
Cdd:TIGR02644 81 STGGVGDKVSLVLGPIVAACGVKVAKMSGRGLGHTGGTIDKLESIPGFRTELSEAEFIEIVNKVGLAIIGQTKDLAPADK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 163 KLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISDMSQP 242
Cdd:TIGR02644 161 KLYALRDVTGTVDSIPLIASSIMSKKLAAGADAIVLDVKVGSGAFMKTLEDAKELAKLMVEIGKGAGRKTSALLTDMNQP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 243 LGEAIGNSLEIVEAIETLQGNGPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQGGDSSV 322
Cdd:TIGR02644 241 LGRAIGNALEVKEAVEFLKGEGPADLKELTLALAAEMLLLAGIAKTEKEARALAEDVLESGKALEKFRRFVEAQGGDPDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 323 VDQPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANRE 402
Cdd:TIGR02644 321 IKNLDKLPKAKYKEEVKAEKSGYISEIDAEELGLAAVDLGAGRARKEDKIDHEAGIYLHKKTGDRVKKGDPLATLYSSDP 400
|
.
gi 488284957 403 D 403
Cdd:TIGR02644 401 I 401
|
|
| deoA |
PRK05820 |
thymidine phosphorylase; Reviewed |
1-433 |
0e+00 |
|
thymidine phosphorylase; Reviewed
Pssm-ID: 180276 [Multi-domain] Cd Length: 440 Bit Score: 550.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 1 MRMVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIE--GIK 78
Cdd:PRK05820 2 FLAQEIIRKKRDGGALSDEEIDWFIDGYTDGTVSDGQIAALAMAIFFNGMTRPERVALTLAMRDSGEVLDWSSLNlnGPI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 79 VDKHSTGGVGDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPGFKVELTEERFIQLVNDTKVAVIGQSGDLA 158
Cdd:PRK05820 82 VDKHSTGGVGDKISLMLAPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYRAFPSNDRFREILKDVGVAIIGQTSDLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 159 PADKKLYALRDVTATVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVISD 238
Cdd:PRK05820 162 PADKRLYALRDVTATVESIPLITASILSKKLAEGLDALVLDVKVGSGAFMKTYEEARELARSMVEVANGAGVRTTALLTD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 239 MSQPLGEAIGNSLEIVEAIETLQGN-GPEDLVEMCYVLGSQMVVLAKKAETLDEARALLEEALTSGRALAKFKEMIENQG 317
Cdd:PRK05820 242 MNQPLASSAGNALEVREAVEFLTGGyRPPRLVEVTMALAAEMLVLAGLAKDEAEARADLAAVLDSGKAAERFGRMVAAQG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 318 GDSSVVDQPEKLL-TATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLT 396
Cdd:PRK05820 322 GPPDFVENYDKYLpTAPHTKPVYADRSGVLSAMDTRALGMAVVRLGGGRRRKGDPIDYSVGLTLHARLGDRVDAGEPLAT 401
|
410 420 430
....*....|....*....|....*....|....*....
gi 488284957 397 IYANRED-VTEVEQLLYKNIEIGPTG-EEPILIHDIITE 433
Cdd:PRK05820 402 LHADDEErFQEAAAALKAAIRIGDEApEATPLIYRRITA 440
|
|
| PRK04350 |
PRK04350 |
thymidine phosphorylase; Provisional |
4-402 |
1.95e-76 |
|
thymidine phosphorylase; Provisional
Pssm-ID: 235289 [Multi-domain] Cd Length: 490 Bit Score: 246.26 E-value: 1.95e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 4 VDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSsiEGIKVDKHS 83
Cdd:PRK04350 82 LSAIRKKIDGEKLDKEEIEAIIRDIVAGRYSDIELSAFLTASAINGLDMDEIEALTRAMVETGERLDWD--RPPVVDKHS 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 84 TGGV-GDTTTLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIPgfKVELTEERFIQLVNDTK-VAVIGQSGDLAPAD 161
Cdd:PRK04350 160 IGGVpGNRTTLIVVPIVAAAGLTIPKTSSRAITSPAGTADTMEVLA--PVDLSVEEIKRVVEKVGgCLVWGGAVNLSPAD 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 162 KKL----YALRdvtatVDSIPLIASSIMSKKIAAGADAIVLDVTTGEGAFMKDLASARRLAETMVRIGKLANRQTMAVIS 237
Cdd:PRK04350 238 DILirveRPLS-----IDPRGQLVASILSKKIAAGSTHVVIDIPVGPTAKVRSVEEARRLARLFEEVGDRLGLRVECAIT 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 238 DMSQPLGEAIGNSLEIVEAIETLQG--NGPEDLVEMCYVLGSQMVVL---AKKAETLDEARALLEealtSGRALAKFKEM 312
Cdd:PRK04350 313 DGSQPIGRGIGPALEARDVLAVLENdpDAPNDLREKSLRLAGILLEMggvAPGGEGYALAREILE----SGKALEKFQEI 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 313 IENQGGDssvvdqPEKLLTATYQFDLPAKETGVVQKIVANEIGVAAMLLGAGRatkedtiDFAVGLKLHKKVGSPVEKGE 392
Cdd:PRK04350 389 IEAQGGD------SEDIPLGDHTHDVTAPRDGYVTAIDNRRLARIARLAGAPK-------DKGAGIDLHVKVGDKVKKGD 455
|
410
....*....|
gi 488284957 393 SLLTIYANRE 402
Cdd:PRK04350 456 PLYTIHAESE 465
|
|
| Glycos_transf_3 |
pfam00591 |
Glycosyl transferase family, a/b domain; This family includes anthranilate ... |
75-306 |
6.01e-54 |
|
Glycosyl transferase family, a/b domain; This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate.
Pssm-ID: 459860 [Multi-domain] Cd Length: 253 Bit Score: 180.18 E-value: 6.01e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 75 EGIKVDKHSTGGVGDTT---TLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIpGFKVELTEERFIQLVNDTKVAVI 151
Cdd:pfam00591 1 LGDLVDIVGTGGDGDNTfniSTAAAIVAAACGVKVAKHGNRSVSSKSGSADVLEAL-GINLDLTPEQVRKLLDEVGVGFL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 152 GQSGDLAPADKKLYALRDVTA-TVDSI--PLIAS--------SIMSKKIAAGADAIVLDVTTGEGAFMK----DLASArr 216
Cdd:pfam00591 80 FAPNYHPAMKHVAPVRRELGIrTVFNLlgPLINParvkrqvlGVYSKELAEGLAEVLKDLGRERAAVVHgdglDEASL-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 217 LAETMVRIGKlANRQTMAVISDMSQPLGEAIGNSLEIV---EAIETLQG--NGPEDLVEMCYVL--GSQMVVLAKKAETL 289
Cdd:pfam00591 158 LGKTTVAELK-DGEITEYTLTPEDFGLGRATLEALEGGspkENADILKGvlGGKGSAAHRDLVAlnAGAALYLAGKADSL 236
|
250
....*....|....*..
gi 488284957 290 DEARALLEEALTSGRAL 306
Cdd:pfam00591 237 KEGVAKALEVIDSGKAL 253
|
|
| PYNP_C |
pfam07831 |
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal ... |
345-417 |
1.61e-26 |
|
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Pssm-ID: 429685 [Multi-domain] Cd Length: 74 Bit Score: 101.50 E-value: 1.61e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488284957 345 VVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANRED-VTEVEQLLYKNIEI 417
Cdd:pfam07831 1 YVSSIDAREIGMAAMELGAGRATKTDPIDYGVGIYLHKKLGDKVKKGEPLATIYANDEIrLEEAVKKLKKAIEI 74
|
|
| PYNP_C |
smart00941 |
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal ... |
345-418 |
3.64e-24 |
|
Pyrimidine nucleoside phosphorylase C-terminal domain; This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer.
Pssm-ID: 214925 [Multi-domain] Cd Length: 75 Bit Score: 94.91 E-value: 3.64e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488284957 345 VVQKIVANEIGVAAMLLGAGRATKEDTIDFAVGLKLHKKVGSPVEKGESLLTIYANREDVTE-VEQLLYKNIEIG 418
Cdd:smart00941 1 YVTAIDARALGLAAVLLGAGRARKEDPIDYGVGIVLHKKLGDRVKKGEPLATIHANDEAELEeAAEALRAAITIS 75
|
|
| Glycos_trans_3N |
pfam02885 |
Glycosyl transferase family, helical bundle domain; This family includes anthranilate ... |
4-66 |
6.36e-22 |
|
Glycosyl transferase family, helical bundle domain; This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase. All these proteins can transfer a phosphorylated ribose substrate.
Pssm-ID: 460737 [Multi-domain] Cd Length: 63 Bit Score: 88.59 E-value: 6.36e-22
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488284957 4 VDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSG 66
Cdd:pfam02885 1 KELIKKLRDGEDLTREEARAAMDGIMSGEATDAQIAAFLMALRMKGETAEEIAGLARAMRESG 63
|
|
| PRK14607 |
PRK14607 |
bifunctional anthranilate synthase component II/anthranilate phosphoribosyltransferase; |
3-146 |
1.81e-09 |
|
bifunctional anthranilate synthase component II/anthranilate phosphoribosyltransferase;
Pssm-ID: 237764 [Multi-domain] Cd Length: 534 Bit Score: 59.73 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 3 MVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMvhSGEIVDLSSIEGIKVDKH 82
Cdd:PRK14607 195 IKSYLKKLVEGEDLSFEEAEDVMEDITDGNATDAQIAGFLTALRMKGETADELAGFASVM--REKSRHIPAPSPRTVDTC 272
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488284957 83 STGGVGDTT---TLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIpGFKVELTEERFIQLVNDT 146
Cdd:PRK14607 273 GTGGDGFGTfniSTTSAFVVAAAGVPVAKHGNRAVSSKSGSADVLEAL-GVKLEMTPEEAASVLRET 338
|
|
| TrpD |
COG0547 |
Anthranilate phosphoribosyltransferase, glycosyltransferase domain [Amino acid transport and ... |
2-309 |
6.42e-08 |
|
Anthranilate phosphoribosyltransferase, glycosyltransferase domain [Amino acid transport and metabolism]; Anthranilate phosphoribosyltransferase, glycosyltransferase domain is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 440313 [Multi-domain] Cd Length: 327 Bit Score: 53.93 E-value: 6.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 2 RMVDIIEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAM--------VHSGEIVDLSs 73
Cdd:COG0547 1 MMKELLKKLAEGKDLTREEAREAMRQIMSGEATPAQIGAFLTALRMKGETVEEIAGFADAMrelavpvpLPDGDVVDIV- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 74 iegikvdkhSTGGVGDTT---TLILAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIpGFKVELTEERFIQLVNDTKVAV 150
Cdd:COG0547 80 ---------GTGGDGANTfniSTAAAFVAAAAGVPVAKHGNRSVSSKSGSADVLEAL-GVNLDLSPEQVARCLEEAGIGF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 151 IGQSGdLAPADKKLYALRDV--TATVDSI--PLIAssimskkiAAGADAIVLdvttgeGAFMKDLasARRLAETMVRIGk 226
Cdd:COG0547 150 LFAPL-FHPAMKHVAPVRKElgVRTIFNLlgPLTN--------PAGPKRQLL------GVYHPEL--VEPLAEVLQLLG- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 227 lanRQTMAVISDM--------SQP--LGEAIGNSLEIVE-----------AIETLQGNGPEDLVEMCY-VL----GSQ-- 278
Cdd:COG0547 212 ---VKRALVVHGLdgldeislTGPtkVAELRDGEIEEYTldpedfglpraPLEDLRGGDAEENAEILRaVLagegGPArd 288
|
330 340 350
....*....|....*....|....*....|....*....
gi 488284957 279 MVVL--------AKKAETLDEARALLEEALTSGRALAKF 309
Cdd:COG0547 289 AVLLnaaaalyvAGKADSLAEGVELAREAIDSGAALAKL 327
|
|
| PLN02641 |
PLN02641 |
anthranilate phosphoribosyltransferase |
6-149 |
3.88e-05 |
|
anthranilate phosphoribosyltransferase
Pssm-ID: 215345 [Multi-domain] Cd Length: 343 Bit Score: 45.49 E-value: 3.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 6 IIEKKRDGHQLTSEEIQFIINGYTDGSIPDyQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDlssieGIK--VDKHS 83
Cdd:PLN02641 7 LIESLIQGTDLTEEEAEAALDFLLDDADEA-QISAFLVLLRAKGETFEEIAGLARAMIKRARKVD-----GLVdaVDIVG 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488284957 84 TGGVGDTTTLI---LAPLVASVGVNVAKMSGRGLGYTGGTLDKLEAIpGFKVELTEERFIQLVNDTKVA 149
Cdd:PLN02641 81 TGGDGANTVNIstgSSILAAACGAKVAKQGNRSSSSACGSADVLEAL-GVAIDLGPEGVKRCVEEVGIG 148
|
|
| trpD |
TIGR01245 |
anthranilate phosphoribosyltransferase; In many widely different species, including E. coli, ... |
7-146 |
3.89e-05 |
|
anthranilate phosphoribosyltransferase; In many widely different species, including E. coli, Thermotoga maritima, and Archaeoglobus fulgidus, this enzymatic domain (anthranilate phosphoribosyltransferase) is found C-terminal to glutamine amidotransferase; the fusion protein is designated anthranilate synthase component II (EC 4.1.3.27) [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273522 [Multi-domain] Cd Length: 330 Bit Score: 45.34 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284957 7 IEKKRDGHQLTSEEIQFIINGYTDGSIPDYQVSAFLMAVFYQDMTDEEITQMTLAMVHSGEIVDLSSIEGIkVDKHSTGG 86
Cdd:TIGR01245 1 LEKLIDGKDLSRDEAEQLMKEIMSGEASPAQIAAILTALRIKGETPEEITGFAKAMREHAVKVPGRPPEDL-VDIVGTGG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488284957 87 VG------DTTTLILAplvASVGVNVAKMSGRGLGYTGGTLDKLEAIpGFKVELTEERFIQLVNDT 146
Cdd:TIGR01245 80 DGantiniSTASAFVA---AAAGVKVAKHGNRSVSSKSGSADVLEAL-GVNLDLGPEKVARSLEET 141
|
|
| |
