|
Name |
Accession |
Description |
Interval |
E-value |
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1-959 |
4.26e-91 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 303.61 E-value: 4.26e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 1 MIIKSLEIYGYGQFVQRKIEFNRQFTEIFGENEAGKSTIQAFIHSILfgfptkkskeprleprlgnqyggklslifddgi 80
Cdd:COG4717 1 MKIKELEIYGFGKFRDRTIEFSPGLNVIYGPNEAGKSTLLAFIRAML--------------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 81 eaeverikgsahgdvkiylkdgtirdevwlnkklnyiskktyqgifsfdvlglqdihknldeeqlqdylleagalgstef 160
Cdd:COG4717 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 161 tsmRDRIGQKKEELYKKSGKNPIINqqIEQLKQLENQIRNEESKLDTYHRLVDDKDKSSRRLENLKQNLNQLSKMHEQKQ 240
Cdd:COG4717 48 ---LERLEKEADELFKPQGRKPELN--LKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE 122
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 241 KEVALHDQTQEWKRLEQSLNIEPinfpekgiDRYEtakshkqslerdkslreerlsilnkeaesinpvdqkyidsfnSLY 320
Cdd:COG4717 123 KLLQLLPLYQELEALEAELAELP--------ERLE------------------------------------------ELE 152
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 321 QQETEIKQKEFELRSIEKDIADKQRELEALQsnigwqevfydTDSTEAMKSHMSDLVLGKQEQIAYINQLERGLEENKIE 400
Cdd:COG4717 153 ERLEELRELEEELEELEAELAELQEELEELL-----------EQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 401 RNSNSNEINQVENELVPDETFEKKKEYTQqvlelhekenlyeklketfeeeqtqknkrqkFLRIGFIVLTILSAALSIFS 480
Cdd:COG4717 222 LEELEEELEQLENELEAAALEERLKEARL-------------------------------LLLIAAALLALLGLGGSLLS 270
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 481 FFTanLIFGIIFALLTVIFVVGIIFSRSKAVDYSTAISQEINDLENQLTQLEkeynldfdleyqqqvreqwrhakknkki 560
Cdd:COG4717 271 LIL--TIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE---------------------------- 320
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 561 leekhqyinqslttanerldslkhsIIEIKKELRLSEKLSDELVVESISTIGQIKAHDKYIIDLNQQRnnllkdinhfye 640
Cdd:COG4717 321 -------------------------LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL------------ 363
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 641 raqsvtephlklfnqmsffhdvkqwlknaeeqneawnknqtetqllnnelkqlksRLSETNQMIKQLFDYVDVDNEEDYY 720
Cdd:COG4717 364 -------------------------------------------------------QLEELEQEIAALLAEAGVEDEEELR 388
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 721 THHHHFETYQSDLNRFNDLNQYLENQNYtyEMSSQLSEKTTAQLEEEDHRLAKQVDDYNDQFLEMQAEVSDLNAQINHME 800
Cdd:COG4717 389 AALEQAEEYQELKEELEELEEQLEELLG--ELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLE 466
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 801 TDRTLAQLRHEYYSLKNRLNDIAKDWASLSYMQALVEEHIKQIKDKRLPQVINEAVSIFKNLTNGTYNMIHYTENHKIHV 880
Cdd:COG4717 467 EDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERASEYFSRLTDGRYRLIRIDEDLSLKV 546
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488386965 881 KHSNGQVFEPVELSQSTKELLYVALRISLIKVLKPyYPFPVIVDDAFVHFDKYRKERMLKYLRELSEHYQILYFTCTKD 959
Cdd:COG4717 547 DTEDGRTRPVEELSRGTREQLYLALRLALAELLAG-EPLPLILDDAFVNFDDERLRAALELLAELAKGRQVIYFTCHEE 624
|
|
| AAA_27 |
pfam13514 |
AAA domain; This domain is found in a number of double-strand DNA break proteins. This domain ... |
1-199 |
3.32e-17 |
|
AAA domain; This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.
Pssm-ID: 433272 [Multi-domain] Cd Length: 207 Bit Score: 81.06 E-value: 3.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 1 MIIKSLEIYGYGQFVQRKIEFNRQ---FTEIFGENEAGKSTIQAFIHSILFGFPTKKS---KEPRLEPRLGnqyggkLSL 74
Cdd:pfam13514 1 MRIRRLDLERYGPFTDRSLDFPAGgpdLHLIYGPNEAGKSTALRAISDLLFGIPLRTPynfLHDYSDLRIG------ATL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 75 IFDDGIEAEVERIKGSAHG--DVkiylkDGTIRDEVWLNKKLNYISKKTYQGIFSFD----VLGLQDIhknLDEE----Q 144
Cdd:pfam13514 75 ENADGETLEFRRRKGRKNTllDA-----DGQPLPDDVLAPFLGGLDRETFERMFGLDherlREGGEAI---LEAEgdlgQ 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 488386965 145 LqdyLLEAGAlGSTEFTSMRDRIGQKKEELYKKSGKNPI-INQQIEQLKQLENQIR 199
Cdd:pfam13514 147 A---LFAAGS-GLAGLRRVLEALDAEADALFKPRGSSPRaFNQALARLDEAQRELR 198
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
159-825 |
6.40e-09 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 60.07 E-value: 6.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 159 EFTSMRDRIGQKKEELYKKSGKNPIINQQIEQLKQLENQIRNEESKLDTYHRLVD-DKDKSSRRLENLKQNLNQLSKMHE 237
Cdd:TIGR02168 275 EVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELEsKLDELAEELAELEEKLEELKEELE 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 238 QKQKEVA-LHDQTQEWKRLEQSLNiepinfpekgiDRYETAKSHKQSLERDKSLREERLSILNKEAESINPVDQKYIDSF 316
Cdd:TIGR02168 355 SLEAELEeLEAELEELESRLEELE-----------EQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEI 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 317 NSLYQ--QETEIKQKEFELRSIEKDIADKQRELEALQsnigwQEVFYDTDSTEAMKSHMSDLVLGKQEQIAYINQLERGL 394
Cdd:TIGR02168 424 EELLKklEEAELKELQAELEELEEELEELQEELERLE-----EALEELREELEEAEQALDAAERELAQLQARLDSLERLQ 498
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 395 EENKiernSNSNEINQVENELvpdetfEKKKEYTQQVLELHEKENLYEKLKETFEEEqtqknkrqkflRIGFIVLTILSA 474
Cdd:TIGR02168 499 ENLE----GFSEGVKALLKNQ------SGLSGILGVLSELISVDEGYEAAIEAALGG-----------RLQAVVVENLNA 557
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 475 ALSIFSFFTANLIFGIIFALLTVIFVVGIIFSRSKAVDYSTAISQEINDLENQLTQLEK--EY---------NLDFDLEY 543
Cdd:TIGR02168 558 AKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalSYllggvlvvdDLDNALEL 637
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 544 QQQVREQWR---------------------------HAKKNKKILEEKHQYINQSLTTANERLDSLKHSIIEIKKELRLS 596
Cdd:TIGR02168 638 AKKLRPGYRivtldgdlvrpggvitggsaktnssilERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 597 EKLSDELVVESISTIGQIKAHDKYIIDLNQQRNNLLKDINHFYERAQSVTEPHLKLFNQmsffhdvkqwlknAEEQNEAW 676
Cdd:TIGR02168 718 RKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE-------------LAEAEAEI 784
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 677 NKNQTETQLLNNELKQLKSRLSETNQMIKQLfdyvdvdNEEdyythhhhfetYQSDLNRFNDLNQYLENQNYTYEMSSQL 756
Cdd:TIGR02168 785 EELEAQIEQLKEELKALREALDELRAELTLL-------NEE-----------AANLRERLESLERRIAATERRLEDLEEQ 846
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488386965 757 SEKTTAQLEEedhrLAKQVDDYNDQFLEMQAEVSDLNAQINHMETDrtLAQLRHEYYSLKNRLNDIAKD 825
Cdd:TIGR02168 847 IEELSEDIES----LAAEIEELEELIEELESELEALLNERASLEEA--LALLRSELEELSEELRELESK 909
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
157-454 |
1.42e-05 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 49.35 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 157 STEFTSMRDRIGQKKEELykksgknpiinqqiEQLKQLENQIRNEESKLDTYHRLVDDKDKSSRRLENLKQNLNQLSKMH 236
Cdd:pfam15921 516 NAEITKLRSRVDLKLQEL--------------QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQH 581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 237 ---------EQKQKEVALHDQTQEWKRLE-----------------QSLNIEPINFPEKGIDRYETAKSHKQslERDKSL 290
Cdd:pfam15921 582 grtagamqvEKAQLEKEINDRRLELQEFKilkdkkdakirelearvSDLELEKVKLVNAGSERLRAVKDIKQ--ERDQLL 659
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 291 REERLSI--LNKEAESINPVDQKYID-------SFNSLYQQ----ETEIKQKEFELRSIE--------------KDIADK 343
Cdd:pfam15921 660 NEVKTSRneLNSLSEDYEVLKRNFRNkseemetTTNKLKMQlksaQSELEQTRNTLKSMEgsdghamkvamgmqKQITAK 739
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 344 QRELEALQSNIGWQEvfydtdstEAMKSHMSDLVLGKQEQiayiNQLERGLEENKIERNSNSNEI-----------NQVE 412
Cdd:pfam15921 740 RGQIDALQSKIQFLE--------EAMTNANKEKHFLKEEK----NKLSQELSTVATEKNKMAGELevlrsqerrlkEKVA 807
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488386965 413 NELVPDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQ 454
Cdd:pfam15921 808 NMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
162-460 |
1.11e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 46.21 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 162 SMRDRIGQKK---EELYKKSGKNP-------------IINQQIEQLKQLENQIR---NEESKLDTYHRLVDDKDKSSRRL 222
Cdd:PRK03918 416 ELKKEIKELKkaiEELKKAKGKCPvcgrelteehrkeLLEEYTAELKRIEKELKeieEKERKLRKELRELEKVLKKESEL 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 223 ENLKQNLNQLSKMhEQKQKEVALHDQTQEWKRLE----QSLNIE-PINFPEKGIDRYETAKSHKQSLERDKSLREERLSI 297
Cdd:PRK03918 496 IKLKELAEQLKEL-EEKLKKYNLEELEKKAEEYEklkeKLIKLKgEIKSLKKELEKLEELKKKLAELEKKLDELEEELAE 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 298 LNKEAESINpvdQKYIDSFNSLYQQETEIKQKEFELRSIEKDIADKQRELEALQSNIgwqevfydtdsteamkshmsdlv 377
Cdd:PRK03918 575 LLKELEELG---FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEEL----------------------- 628
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 378 lgkQEQIAYINQLERGLEENKIERNSNSNEINQVENELVPDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQKNK 457
Cdd:PRK03918 629 ---DKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEE 705
|
...
gi 488386965 458 RQK 460
Cdd:PRK03918 706 REK 708
|
|
| ABC_SMC_barmotin |
cd03278 |
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a ... |
3-76 |
9.76e-04 |
|
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Pssm-ID: 213245 [Multi-domain] Cd Length: 197 Bit Score: 41.30 E-value: 9.76e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488386965 3 IKSLEIYGYGQFVQR-KIEFNRQFTEIFGENEAGKSTIqafIHSILFGFPTKKSKEPRleprlgnqyGGKLS-LIF 76
Cdd:cd03278 1 LKKLELKGFKSFADKtTIPFPPGLTAIVGPNGSGKSNI---IDAIRWVLGEQSAKSLR---------GEKMSdVIF 64
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1-959 |
4.26e-91 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 303.61 E-value: 4.26e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 1 MIIKSLEIYGYGQFVQRKIEFNRQFTEIFGENEAGKSTIQAFIHSILfgfptkkskeprleprlgnqyggklslifddgi 80
Cdd:COG4717 1 MKIKELEIYGFGKFRDRTIEFSPGLNVIYGPNEAGKSTLLAFIRAML--------------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 81 eaeverikgsahgdvkiylkdgtirdevwlnkklnyiskktyqgifsfdvlglqdihknldeeqlqdylleagalgstef 160
Cdd:COG4717 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 161 tsmRDRIGQKKEELYKKSGKNPIINqqIEQLKQLENQIRNEESKLDTYHRLVDDKDKSSRRLENLKQNLNQLSKMHEQKQ 240
Cdd:COG4717 48 ---LERLEKEADELFKPQGRKPELN--LKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE 122
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 241 KEVALHDQTQEWKRLEQSLNIEPinfpekgiDRYEtakshkqslerdkslreerlsilnkeaesinpvdqkyidsfnSLY 320
Cdd:COG4717 123 KLLQLLPLYQELEALEAELAELP--------ERLE------------------------------------------ELE 152
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 321 QQETEIKQKEFELRSIEKDIADKQRELEALQsnigwqevfydTDSTEAMKSHMSDLVLGKQEQIAYINQLERGLEENKIE 400
Cdd:COG4717 153 ERLEELRELEEELEELEAELAELQEELEELL-----------EQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 401 RNSNSNEINQVENELVPDETFEKKKEYTQqvlelhekenlyeklketfeeeqtqknkrqkFLRIGFIVLTILSAALSIFS 480
Cdd:COG4717 222 LEELEEELEQLENELEAAALEERLKEARL-------------------------------LLLIAAALLALLGLGGSLLS 270
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 481 FFTanLIFGIIFALLTVIFVVGIIFSRSKAVDYSTAISQEINDLENQLTQLEkeynldfdleyqqqvreqwrhakknkki 560
Cdd:COG4717 271 LIL--TIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE---------------------------- 320
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 561 leekhqyinqslttanerldslkhsIIEIKKELRLSEKLSDELVVESISTIGQIKAHDKYIIDLNQQRnnllkdinhfye 640
Cdd:COG4717 321 -------------------------LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL------------ 363
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 641 raqsvtephlklfnqmsffhdvkqwlknaeeqneawnknqtetqllnnelkqlksRLSETNQMIKQLFDYVDVDNEEDYY 720
Cdd:COG4717 364 -------------------------------------------------------QLEELEQEIAALLAEAGVEDEEELR 388
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 721 THHHHFETYQSDLNRFNDLNQYLENQNYtyEMSSQLSEKTTAQLEEEDHRLAKQVDDYNDQFLEMQAEVSDLNAQINHME 800
Cdd:COG4717 389 AALEQAEEYQELKEELEELEEQLEELLG--ELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLE 466
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 801 TDRTLAQLRHEYYSLKNRLNDIAKDWASLSYMQALVEEHIKQIKDKRLPQVINEAVSIFKNLTNGTYNMIHYTENHKIHV 880
Cdd:COG4717 467 EDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERASEYFSRLTDGRYRLIRIDEDLSLKV 546
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488386965 881 KHSNGQVFEPVELSQSTKELLYVALRISLIKVLKPyYPFPVIVDDAFVHFDKYRKERMLKYLRELSEHYQILYFTCTKD 959
Cdd:COG4717 547 DTEDGRTRPVEELSRGTREQLYLALRLALAELLAG-EPLPLILDDAFVNFDDERLRAALELLAELAKGRQVIYFTCHEE 624
|
|
| AAA_27 |
pfam13514 |
AAA domain; This domain is found in a number of double-strand DNA break proteins. This domain ... |
1-199 |
3.32e-17 |
|
AAA domain; This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.
Pssm-ID: 433272 [Multi-domain] Cd Length: 207 Bit Score: 81.06 E-value: 3.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 1 MIIKSLEIYGYGQFVQRKIEFNRQ---FTEIFGENEAGKSTIQAFIHSILFGFPTKKS---KEPRLEPRLGnqyggkLSL 74
Cdd:pfam13514 1 MRIRRLDLERYGPFTDRSLDFPAGgpdLHLIYGPNEAGKSTALRAISDLLFGIPLRTPynfLHDYSDLRIG------ATL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 75 IFDDGIEAEVERIKGSAHG--DVkiylkDGTIRDEVWLNKKLNYISKKTYQGIFSFD----VLGLQDIhknLDEE----Q 144
Cdd:pfam13514 75 ENADGETLEFRRRKGRKNTllDA-----DGQPLPDDVLAPFLGGLDRETFERMFGLDherlREGGEAI---LEAEgdlgQ 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 488386965 145 LqdyLLEAGAlGSTEFTSMRDRIGQKKEELYKKSGKNPI-INQQIEQLKQLENQIR 199
Cdd:pfam13514 147 A---LFAAGS-GLAGLRRVLEALDAEADALFKPRGSSPRaFNQALARLDEAQRELR 198
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
159-825 |
6.40e-09 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 60.07 E-value: 6.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 159 EFTSMRDRIGQKKEELYKKSGKNPIINQQIEQLKQLENQIRNEESKLDTYHRLVD-DKDKSSRRLENLKQNLNQLSKMHE 237
Cdd:TIGR02168 275 EVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELEsKLDELAEELAELEEKLEELKEELE 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 238 QKQKEVA-LHDQTQEWKRLEQSLNiepinfpekgiDRYETAKSHKQSLERDKSLREERLSILNKEAESINPVDQKYIDSF 316
Cdd:TIGR02168 355 SLEAELEeLEAELEELESRLEELE-----------EQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEI 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 317 NSLYQ--QETEIKQKEFELRSIEKDIADKQRELEALQsnigwQEVFYDTDSTEAMKSHMSDLVLGKQEQIAYINQLERGL 394
Cdd:TIGR02168 424 EELLKklEEAELKELQAELEELEEELEELQEELERLE-----EALEELREELEEAEQALDAAERELAQLQARLDSLERLQ 498
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 395 EENKiernSNSNEINQVENELvpdetfEKKKEYTQQVLELHEKENLYEKLKETFEEEqtqknkrqkflRIGFIVLTILSA 474
Cdd:TIGR02168 499 ENLE----GFSEGVKALLKNQ------SGLSGILGVLSELISVDEGYEAAIEAALGG-----------RLQAVVVENLNA 557
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 475 ALSIFSFFTANLIFGIIFALLTVIFVVGIIFSRSKAVDYSTAISQEINDLENQLTQLEK--EY---------NLDFDLEY 543
Cdd:TIGR02168 558 AKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalSYllggvlvvdDLDNALEL 637
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 544 QQQVREQWR---------------------------HAKKNKKILEEKHQYINQSLTTANERLDSLKHSIIEIKKELRLS 596
Cdd:TIGR02168 638 AKKLRPGYRivtldgdlvrpggvitggsaktnssilERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 597 EKLSDELVVESISTIGQIKAHDKYIIDLNQQRNNLLKDINHFYERAQSVTEPHLKLFNQmsffhdvkqwlknAEEQNEAW 676
Cdd:TIGR02168 718 RKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE-------------LAEAEAEI 784
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 677 NKNQTETQLLNNELKQLKSRLSETNQMIKQLfdyvdvdNEEdyythhhhfetYQSDLNRFNDLNQYLENQNYTYEMSSQL 756
Cdd:TIGR02168 785 EELEAQIEQLKEELKALREALDELRAELTLL-------NEE-----------AANLRERLESLERRIAATERRLEDLEEQ 846
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488386965 757 SEKTTAQLEEedhrLAKQVDDYNDQFLEMQAEVSDLNAQINHMETDrtLAQLRHEYYSLKNRLNDIAKD 825
Cdd:TIGR02168 847 IEELSEDIES----LAAEIEELEELIEELESELEALLNERASLEEA--LALLRSELEELSEELRELESK 909
|
|
| AAA_23 |
pfam13476 |
AAA domain; |
6-196 |
5.88e-07 |
|
AAA domain;
Pssm-ID: 463890 [Multi-domain] Cd Length: 190 Bit Score: 50.96 E-value: 5.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 6 LEIYGYGQFVQRKIEFNRQFTEIFGENEAGKSTIQAFIHSILFGFPTKKSKEprlepRLGNQYGGKLSLIFDDGIEAEVE 85
Cdd:pfam13476 1 LTIENFRSFRDQTIDFSKGLTLITGPNGSGKTTILDAIKLALYGKTSRLKRK-----SGGGFVKGDIRIGLEGKGKAYVE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 86 RIKGSAHGDvkiylKDGTIRDEVWLNKKLNYISKKTYQGIFSFDVLG--LQDIHKNLDEEQLQDYLLEAGALGSTEFTSM 163
Cdd:pfam13476 76 ITFENNDGR-----YTYAIERSRELSKKKGKTKKKEILEILEIDELQqfISELLKSDKIILPLLVFLGQEREEEFERKEK 150
|
170 180 190
....*....|....*....|....*....|...
gi 488386965 164 RDRIGQKKEELYKKSGKNPIINQQIEQLKQLEN 196
Cdd:pfam13476 151 KERLEELEKALEEKEDEKKLLEKLLQLKEKKKE 183
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
3-463 |
8.46e-07 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 53.15 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 3 IKSLEIYGYGQFVQRK-IEFNRQFTEIFGENEAGKSTIqafIHSILFGFPTKKSKEPRLEprlgnqyggKLS-LIFDDgi 80
Cdd:TIGR02169 2 IERIELENFKSFGKKKvIPFSKGFTVISGPNGSGKSNI---GDAILFALGLSSSKAMRAE---------RLSdLISNG-- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 81 eaevERIKGSAHGDVKIYLK--DGTIRDEVWLNKKLNyISKKTYQGIFSFD--VLGLQDIHknldeEQLQDYLLEAGALG 156
Cdd:TIGR02169 68 ----KNGQSGNEAYVTVTFKndDGKFPDELEVVRRLK-VTDDGKYSYYYLNgqRVRLSEIH-----DFLAAAGIYPEGYN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 157 S------TEFTSMRDRIGQKkeelykksgknpiINQQIEQLKQLENQIRNEESKLDTYHRLVddkDKSSRRLENLKQNLN 230
Cdd:TIGR02169 138 VvlqgdvTDFISMSPVERRK-------------IIDEIAGVAEFDRKKEKALEELEEVEENI---ERLDLIIDEKRQQLE 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 231 QLSKMHEQKQKEVALHDQTQEwkrLEQSLNIEPINFPEKGIdryETAKSHKQSLERDKSLREERLSILNKEAESINPVDQ 310
Cdd:TIGR02169 202 RLRREREKAERYQALLKEKRE---YEGYELLKEKEALERQK---EAIERQLASLEEELEKLTEEISELEKRLEEIEQLLE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 311 KYIDSFNSLYQQE-----TEIKQKEFELRSIEKDIADKQRELEALQSNIGWQEVFYDtdsteAMKSHMSDLVLGKQEQIA 385
Cdd:TIGR02169 276 ELNKKIKDLGEEEqlrvkEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEID-----KLLAEIEELEREIEEERK 350
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488386965 386 YINQLERGLEENKIERNSNSNEINQVENELvpDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQKNKRQKFLR 463
Cdd:TIGR02169 351 RRDKLTEEYAELKEELEDLRAELEEVDKEF--AETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLN 426
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
180-846 |
4.34e-06 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 50.82 E-value: 4.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 180 KNPIINQQIEQLKQLENQIRNEESKLDTYHRLVDDKDKSSRRLENLKQNLNQLSKMHEQKQKEVALHDQTQEWKRLEQSL 259
Cdd:TIGR00606 445 KKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEM 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 260 niepinfpeKGIDRYETAKSHKQSLERDKSLREERLSILNKEAESINPVDQKYidsFNSLYQQETEIKQKEFELRSIEKD 339
Cdd:TIGR00606 525 ---------EQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGY---FPNKKQLEDWLHSKSKEINQTRDR 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 340 IADKQRELEALQSNigWQEVFYDTDSTEAMKSHMSDL---VLGKQEQIAYINQLERGLEENKIER-------NSNSNEIN 409
Cdd:TIGR00606 593 LAKLNKELASLEQN--KNHINNELESKEEQLSSYEDKlfdVCGSQDEESDLERLKEEIEKSSKQRamlagatAVYSQFIT 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 410 QVENE-----LVPDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQKNKRQKflrigfIVLTILSAALSIFSffta 484
Cdd:TIGR00606 671 QLTDEnqsccPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRD------EMLGLAPGRQSIID---- 740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 485 nlifgiifalltvIFVVGIIFSRSKAVDYSTAISQEINDLENQLTQL-------EKEYNLDFDLEYQQQVREQWRHAKKN 557
Cdd:TIGR00606 741 -------------LKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLgtimpeeESAKVCLTDVTIMERFQMELKDVERK 807
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 558 KKILEEKHQYIN--QSLTTANERLDSLKHSIIEIKKELRLSEKLSD---ELVVESISTIGQIKAHDKYIIDLNQQRNNLL 632
Cdd:TIGR00606 808 IAQQAAKLQGSDldRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQdqqEQIQHLKSKTNELKSEKLQIGTNLQRRQQFE 887
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 633 KDINHFYERAQSVTEPHLKLFNQMSFFHDVKQwlKNAEEQNEAWNKNQTETQLLNNELKQLKSRLSETNQMIKQLFDYVD 712
Cdd:TIGR00606 888 EQLVELSTEVQSLIREIKDAKEQDSPLETFLE--KDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQ 965
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 713 VDNEEDYYTHHHHFETYQSDLNRFNDLNQYLENQNYTYEMSSQLSEKTTAQLEEEDHRLAKqvddyNDQFLEMQAEVSDL 792
Cdd:TIGR00606 966 DGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKR-----ENELKEVEEELKQH 1040
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
gi 488386965 793 NAQINHMEtdrtLAQLRHEYYSLKNRLNDIAKDWASLSYMQALVEEHIKQIKDK 846
Cdd:TIGR00606 1041 LKEMGQMQ----VLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKE 1090
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
157-454 |
1.42e-05 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 49.35 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 157 STEFTSMRDRIGQKKEELykksgknpiinqqiEQLKQLENQIRNEESKLDTYHRLVDDKDKSSRRLENLKQNLNQLSKMH 236
Cdd:pfam15921 516 NAEITKLRSRVDLKLQEL--------------QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQH 581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 237 ---------EQKQKEVALHDQTQEWKRLE-----------------QSLNIEPINFPEKGIDRYETAKSHKQslERDKSL 290
Cdd:pfam15921 582 grtagamqvEKAQLEKEINDRRLELQEFKilkdkkdakirelearvSDLELEKVKLVNAGSERLRAVKDIKQ--ERDQLL 659
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 291 REERLSI--LNKEAESINPVDQKYID-------SFNSLYQQ----ETEIKQKEFELRSIE--------------KDIADK 343
Cdd:pfam15921 660 NEVKTSRneLNSLSEDYEVLKRNFRNkseemetTTNKLKMQlksaQSELEQTRNTLKSMEgsdghamkvamgmqKQITAK 739
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 344 QRELEALQSNIGWQEvfydtdstEAMKSHMSDLVLGKQEQiayiNQLERGLEENKIERNSNSNEI-----------NQVE 412
Cdd:pfam15921 740 RGQIDALQSKIQFLE--------EAMTNANKEKHFLKEEK----NKLSQELSTVATEKNKMAGELevlrsqerrlkEKVA 807
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488386965 413 NELVPDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQ 454
Cdd:pfam15921 808 NMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
|
|
| SbcC |
COG0419 |
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
2-89 |
2.33e-05 |
|
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
Pssm-ID: 440188 [Multi-domain] Cd Length: 204 Bit Score: 46.54 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 2 IIKSLEIYGYGQFVQR-KIEFNRQFTEIFGENEAGKSTIQAFIHSILFGFPTKKSKEPRLEPRLGNQyGGKLSLIFD-DG 79
Cdd:COG0419 1 KLLRLRLENFRSYRDTeTIDFDDGLNLIVGPNGAGKSTILEAIRYALYGKARSRSKLRSDLINVGSE-EASVELEFEhGG 79
|
90
....*....|
gi 488386965 80 IEAEVERIKG 89
Cdd:COG0419 80 KRYRIERRQG 89
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
189-463 |
1.10e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.08 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 189 EQLKQLENQIRNEESKLDtyhRLVDDKDKSSRRLENLKQNLNQLSKMHEQKQKEVALHDQTQEwkRLEQSLNIEpinfpe 268
Cdd:COG1196 239 AELEELEAELEELEAELE---ELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELA--RLEQDIARL------ 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 269 kgIDRYETAKSHKQSLERDKSLREERLSILNKEAEsinpvdqkyidsfnslyQQETEIKQKEFELRSIEKDIADKQRELE 348
Cdd:COG1196 308 --EERRRELEERLEELEEELAELEEELEELEEELE-----------------ELEEELEEAEEELEEAEAELAEAEEALL 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 349 ALQSNI-GWQEvfydtdSTEAMKSHMSDLVLGKQEQIAYINQLERGLEENKIERNSNSNEINQVENELvpDETFEKKKEY 427
Cdd:COG1196 369 EAEAELaEAEE------ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL--AELEEEEEEE 440
|
250 260 270
....*....|....*....|....*....|....*.
gi 488386965 428 TQQVLELHEKENLYEKLKETFEEEQTQKNKRQKFLR 463
Cdd:COG1196 441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLE 476
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
162-460 |
1.11e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 46.21 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 162 SMRDRIGQKK---EELYKKSGKNP-------------IINQQIEQLKQLENQIR---NEESKLDTYHRLVDDKDKSSRRL 222
Cdd:PRK03918 416 ELKKEIKELKkaiEELKKAKGKCPvcgrelteehrkeLLEEYTAELKRIEKELKeieEKERKLRKELRELEKVLKKESEL 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 223 ENLKQNLNQLSKMhEQKQKEVALHDQTQEWKRLE----QSLNIE-PINFPEKGIDRYETAKSHKQSLERDKSLREERLSI 297
Cdd:PRK03918 496 IKLKELAEQLKEL-EEKLKKYNLEELEKKAEEYEklkeKLIKLKgEIKSLKKELEKLEELKKKLAELEKKLDELEEELAE 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 298 LNKEAESINpvdQKYIDSFNSLYQQETEIKQKEFELRSIEKDIADKQRELEALQSNIgwqevfydtdsteamkshmsdlv 377
Cdd:PRK03918 575 LLKELEELG---FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEEL----------------------- 628
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 378 lgkQEQIAYINQLERGLEENKIERNSNSNEINQVENELVPDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQKNK 457
Cdd:PRK03918 629 ---DKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEE 705
|
...
gi 488386965 458 RQK 460
Cdd:PRK03918 706 REK 708
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
169-460 |
2.57e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.13 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 169 QKKEELYKKSGKNpiiNQQIEQLKQLENQIRNEESKLDTYHrlVDDKDKSSRRLENLKQNLNQLSKMHEQKQKEVAlhDQ 248
Cdd:PTZ00121 1457 KKAEEAKKKAEEA---KKADEAKKKAEEAKKADEAKKKAEE--AKKKADEAKKAAEAKKKADEAKKAEEAKKADEA--KK 1529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 249 TQEWKRLEQSLNIEPINFPEKGIDRYETAKSHKQSLERDKSLREERLSILNKEAESINPVDQKYIDSFNSLYQQETEIKQ 328
Cdd:PTZ00121 1530 AEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 329 KEFELRSIEKDIADKQRElealqsnigwqevfydtdsTEAMKSHMSDLVLGKQEQIAYINQLERGLEENKI---ERNSNS 405
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEELKK-------------------AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIkaaEEAKKA 1670
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 488386965 406 NEINQVENELVPDETFEKKKEytQQVLELHEKENLYEKLKETFEEEQTQKNKRQK 460
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEKKAA--EALKKEAEEAKKAEELKKKEAEEKKKAEELKK 1723
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
186-446 |
3.32e-04 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 44.65 E-value: 3.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 186 QQIEQLKQLENQIRNEESKLDTYHRLVDDKDKSSRRLENLKQNLNQLSKMHEQKQKEVALHDQTQEWKRLE-QSLNIEPI 264
Cdd:PRK02224 475 ERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERaAELEAEAE 554
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 265 NFPEKGIDRYETAKSHKQ---SLERDKSLREERLSILNKEAESINPVDQkYIDSFNSLYQQETEIKQKEFELRSIEKDIA 341
Cdd:PRK02224 555 EKREAAAEAEEEAEEAREevaELNSKLAELKERIESLERIRTLLAAIAD-AEDEIERLREKREALAELNDERRERLAEKR 633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 342 DKQRELEALqsnigwqevfYDTDSTEAMKSHmsdlvlgKQEQIAYINQLERGLEENKIERNSNSNEINQVENELvpdETF 421
Cdd:PRK02224 634 ERKRELEAE----------FDEARIEEARED-------KERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL---EEL 693
|
250 260
....*....|....*....|....*.
gi 488386965 422 EKKKEYTQQVLELHEK-ENLYEKLKE 446
Cdd:PRK02224 694 EELRERREALENRVEAlEALYDEAEE 719
|
|
| COG3950 |
COG3950 |
Predicted ATP-binding protein involved in virulence [General function prediction only]; |
1-76 |
6.41e-04 |
|
Predicted ATP-binding protein involved in virulence [General function prediction only];
Pssm-ID: 443150 [Multi-domain] Cd Length: 276 Bit Score: 42.68 E-value: 6.41e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488386965 1 MIIKSLEIYGYGQFVQRKIEFN--RQFTEIFGENEAGKSTIQAFIHSILFGFPTKKSKEPRLEPRLGN-QYGGKLSLIF 76
Cdd:COG3950 1 MRIKSLTIENFRGFEDLEIDFDnpPRLTVLVGENGSGKTTLLEAIALALSGLLSRLDDVKFRKLLIRNgEFGDSAKLIL 79
|
|
| ABC_SMC_barmotin |
cd03278 |
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a ... |
3-76 |
9.76e-04 |
|
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Pssm-ID: 213245 [Multi-domain] Cd Length: 197 Bit Score: 41.30 E-value: 9.76e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488386965 3 IKSLEIYGYGQFVQR-KIEFNRQFTEIFGENEAGKSTIqafIHSILFGFPTKKSKEPRleprlgnqyGGKLS-LIF 76
Cdd:cd03278 1 LKKLELKGFKSFADKtTIPFPPGLTAIVGPNGSGKSNI---IDAIRWVLGEQSAKSLR---------GEKMSdVIF 64
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
189-354 |
1.05e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 43.08 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 189 EQLKQLENQIRNEESKLDTY---HRLVDDKDKSSRRLENLKQNLNQLSKMHEQKQKEVALHDQTQewKRLEQSLNIEPIN 265
Cdd:COG3206 182 EQLPELRKELEEAEAALEEFrqkNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALR--AQLGSGPDALPEL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 266 FPEKGI----DRYETAKSHKQSLERD--------KSLREERLSILNKEAESINPVDQKYIDSFNSLYQQETEIKQKEFEL 333
Cdd:COG3206 260 LQSPVIqqlrAQLAELEAELAELSARytpnhpdvIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQL 339
|
170 180
....*....|....*....|.
gi 488386965 334 RSIEKDIADKQRELEALQSNI 354
Cdd:COG3206 340 EARLAELPELEAELRRLEREV 360
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
164-353 |
1.55e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 42.06 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 164 RDRIGQKKEELYKKSGKnpiINQQIEQLKQLENQIRNEESKLDTYHRlvdDKDKSSRRLENLKQNLNQLSKMHEQKQKEV 243
Cdd:COG4942 33 QQEIAELEKELAALKKE---EKALLKQLAALERRIAALARRIRALEQ---ELAALEAELAELEKEIAELRAELEAQKEEL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 244 AlhDQTQEWKRLEQSLNIEPINFPEKGIDRYETAKSHKQSLERDKSLREE------RLSILNKEAESINPVDQKYIDSFN 317
Cdd:COG4942 107 A--ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEElradlaELAALRAELEAERAELEALLAELE 184
|
170 180 190
....*....|....*....|....*....|....*..
gi 488386965 318 SLYQQ-ETEIKQKEFELRSIEKDIADKQRELEALQSN 353
Cdd:COG4942 185 EERAAlEALKAERQKLLARLEKELAELAAELAELQQE 221
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
661-828 |
2.06e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 41.74 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 661 DVKQWLKNAEEQNEAWNKNQTETQLLNNELKQLKSRLSETNQMIKQL-----------------FDYVDV----DNEEDY 719
Cdd:COG3883 38 ELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERreelgeraralyrsggsVSYLDVllgsESFSDF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 720 ythhhhfetyqsdLNRFNDLNQYLENQNytyEMSSQLsEKTTAQLEEEDHRLAKQVDDYNDQFLEMQAEVSDLNAQINhm 799
Cdd:COG3883 118 -------------LDRLSALSKIADADA---DLLEEL-KADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQA-- 178
|
170 180
....*....|....*....|....*....
gi 488386965 800 ETDRTLAQLRHEYYSLKNRLNDIAKDWAS 828
Cdd:COG3883 179 EQEALLAQLSAEEAAAEAQLAELEAELAA 207
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
270-862 |
3.08e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 41.59 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 270 GIDRYETAKSHKQSLERDKSLREERLSILNKEAESINpvdqkyidsfNSLYQQETEIKQKEFELRSIEKDIADKQRELEA 349
Cdd:PRK03918 156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIE----------ELIKEKEKELEEVLREINEISSELPELREELEK 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 350 LQSNIgwqevfydtdstEAMKSHMSDLVlGKQEQIAYINQLERGLEENKIERNSNSNEINQVENELvpdetfekkKEYTQ 429
Cdd:PRK03918 226 LEKEV------------KELEELKEEIE-ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL---------EEKVK 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 430 QVLELHEKENLYEKLKETFEEEQTQKNKRQKFLRIGFIVLTILSAALSIFSFFTANL--IFGIIFALLTVIfvvGIIFSR 507
Cdd:PRK03918 284 ELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLeeLKKKLKELEKRL---EELEER 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 508 SKAVDYSTAISQEINDLENQLTQLEKEynldfdleyqqQVREQWRHAKKNKKILEEKHQYINQSLTTANERLDSLKHSII 587
Cdd:PRK03918 361 HELYEEAKAKKEELERLKKRLTGLTPE-----------KLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIE 429
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 588 EIKKELR--------LSEKLSDELVVESISTIGQIKAHDKYIIDLNQQRNNLLKDInhfyeraqsvtEPHLKLFNQMSFF 659
Cdd:PRK03918 430 ELKKAKGkcpvcgreLTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL-----------EKVLKKESELIKL 498
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 660 HDVKQWLKNAEEQNEAWN-----KNQTETQLLNNELKQLKSRLSETNQMIKQLFDYVD--------VDNEEDYYTHHHH- 725
Cdd:PRK03918 499 KELAEQLKELEEKLKKYNleeleKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKklaelekkLDELEEELAELLKe 578
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 726 -----FETYQSDLNRFNDL----NQYLENQNYTYEMSSQlsEKTTAQLEEEDHRLAKQVDDYNDQFLEMQAEVSDLNAQI 796
Cdd:PRK03918 579 leelgFESVEELEERLKELepfyNEYLELKDAEKELERE--EKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKY 656
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 797 N----------HMETDRTLAQLRHEYYSLKNRLNDIAKDWASLSYMQALVEEHIKQIKD--KRLP--QVINEAVSIFKNL 862
Cdd:PRK03918 657 SeeeyeelreeYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKleKALErvEELREKVKKYKAL 736
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
142-257 |
3.58e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 40.92 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 142 EEQLQDYLLEAgalgsteftsmRDRIGQKKEELYKKsgknpiINQQIEQLKQLENQIRNEESKLDTYHRLVDDKDkssRR 221
Cdd:PRK12704 52 EAIKKEALLEA-----------KEEIHKLRNEFEKE------LRERRNELQKLEKRLLQKEENLDRKLELLEKRE---EE 111
|
90 100 110
....*....|....*....|....*....|....*..
gi 488386965 222 LENLKQNLNQLSKMHEQKQKEV-ALHDQTQEwkRLEQ 257
Cdd:PRK12704 112 LEKKEKELEQKQQELEKKEEELeELIEEQLQ--ELER 146
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
134-354 |
3.65e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.44 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 134 QDIHKNLDEEQLQDYLLEAGAL--GSTEFTSMRDRIGQKKEELykksgknpiiNQQIEQLKQLENQIRNEESKLDTYHRL 211
Cdd:COG4913 262 ERYAAARERLAELEYLRAALRLwfAQRRLELLEAELEELRAEL----------ARLEAELERLEARLDALREELDELEAQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 212 VDDKDksSRRLENLKQnlnqlskmhEQKQKEVALHDQTQEWKRLEQSLniepinfpeKGIDryETAKSHKQSLERDKSLR 291
Cdd:COG4913 332 IRGNG--GDRLEQLER---------EIERLERELEERERRRARLEALL---------AALG--LPLPASAEEFAALRAEA 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488386965 292 EERLSILNKEAESINpvdqkyidsfNSLYQQETEIKQKEFELRSIEKDIAdkqrELEALQSNI 354
Cdd:COG4913 390 AALLEALEEELEALE----------EALAEAEAALRDLRRELRELEAEIA----SLERRKSNI 438
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
213-458 |
3.68e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 40.90 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 213 DDKDKSSRRLENLKQNLNQLSKMHEQKQKEVAlhDQTQEWKRLEQSLNiepinfpekgidryETAKSHKQsLERDKSLRE 292
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEK--ALLKQLAALERRIA--------------ALARRIRA-LEQELAALE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 293 ERLSILNKEAE----SINPVDQKYIDSFNSLYQQEteiKQKEFELRSIEKDIADKQRELEALQsnigwQEVFYDTDSTEA 368
Cdd:COG4942 83 AELAELEKEIAelraELEAQKEELAELLRALYRLG---RQPPLALLLSPEDFLDAVRRLQYLK-----YLAPARREQAEE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 369 MKSHMSDLVLGKQEQIAYINQLERGLEENKIERNSNSNEINQVENELvpDETFEKKKEYTQQVLELHEKENLYEKLKETF 448
Cdd:COG4942 155 LRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLL--ARLEKELAELAAELAELQQEAEELEALIARL 232
|
250
....*....|
gi 488386965 449 EEEQTQKNKR 458
Cdd:COG4942 233 EAEAAAAAER 242
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
184-447 |
3.88e-03 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 41.15 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 184 INQQIEQLKQLENQIRNEESKLDTYHRLVDDKDKSSrrlenlKQNLNQLSKMHEQKQKEValhdqtQEWKRLEQSLNIEP 263
Cdd:PHA02562 176 IRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKN------GENIARKQNKYDELVEEA------KTIKAEIEELTDEL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 264 INFPEKGIDRYETAKSHKQSLERDKSlreeRLSILNKEA----------------ESINPVDQKYIDSFNSLYQQETEIK 327
Cdd:PHA02562 244 LNLVMDIEDPSAALNKLNTAAAKIKS----KIEQFQKVIkmyekggvcptctqqiSEGPDRITKIKDKLKELQHSLEKLD 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 328 QKEFELRSIEKDIADKQRELEALQSNIgwqevfydtdSTEamkshmsdlvlgKQEQIAYINQ---LERGLEENKIERNSN 404
Cdd:PHA02562 320 TAIDELEEIMDEFNEQSKKLLELKNKI----------STN------------KQSLITLVDKakkVKAAIEELQAEFVDN 377
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 488386965 405 SNEINQVENELVpdetfEKKKEYTQQVLELHEKENLYEKLKET 447
Cdd:PHA02562 378 AEELAKLQDELD-----KIVKTKSELVKEKYHRGIVTDLLKDS 415
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
521-842 |
6.18e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 40.69 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 521 INDLENQLTQLEKE------YnldfdLEYQQQVRE--------QWRHAKKNKKILEEKHQYINQSLTTANERLDSLKHSI 586
Cdd:COG1196 195 LGELERQLEPLERQaekaerY-----RELKEELKEleaellllKLRELEAELEELEAELEELEAELEELEAELAELEAEL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 587 IEIKKELRLSEKLSDELVVESISTIGQIKAHDKYIIDLNQQRNNLLKDINHFYERAQSVTEphlklfnqmsffhDVKQWL 666
Cdd:COG1196 270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE-------------ELEELE 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 667 KNAEEQNEAWNKNQTETQLLNNELKQLKSRLSETNQMIKQLfdyvdvdnEEDYYTHHHHFETYQSDLNRFNDLNQYLENQ 746
Cdd:COG1196 337 EELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA--------EEELEELAEELLEALRAAAELAAQLEELEEA 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 747 NYTYEMSSQLSEKTTAQLEEEDHRLAKQVDDYNDQFLEMQAEVSDLNAQInhMETDRTLAQLRHEYYSLKNRLNDIAKDW 826
Cdd:COG1196 409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE--EALLELLAELLEEAALLEAALAELLEEL 486
|
330
....*....|....*.
gi 488386965 827 ASLSYMQALVEEHIKQ 842
Cdd:COG1196 487 AEAAARLLLLLEAEAD 502
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
665-847 |
6.71e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 40.43 E-value: 6.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 665 WLKNAEEQNEAWNKNQTETQLLNNELKQLKSRLSETNQMIKQLFDYVDVDNEEdyythhhhFETYQSDLNRF----NDLN 740
Cdd:TIGR02168 230 LVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEE--------IEELQKELYALaneiSRLE 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 741 Q----------YLENQNYTYEMSSQLSEKTTAQLEEEDHRLAKQVDDYNDQFLEMQAEVSDLNAQINHMEtdRTLAQLRH 810
Cdd:TIGR02168 302 QqkqilrerlaNLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELE--SRLEELEE 379
|
170 180 190
....*....|....*....|....*....|....*..
gi 488386965 811 EYYSLKNRLNDIAKDWASLSYMQALVEEHIKQIKDKR 847
Cdd:TIGR02168 380 QLETLRSKVAQLELQIASLNNEIERLEARLERLEDRR 416
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1-463 |
8.54e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 40.05 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 1 MIIKSLEIYGYGQFVQRKIEFNRQFTEIFGENEAGKSTI-QAFIHSILFGFPTKKSKEPRLEPRLGNQYGGKLSLIFD-D 78
Cdd:PRK03918 1 MKIEELKIKNFRSHKSSVVEFDDGINLIIGQNGSGKSSIlEAILVGLYWGHGSKPKGLKKDDFTRIGGSGTEIELKFEkN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 79 GIEAEVER--IKGSAH-----GDVKIYLKDGTIRD--------EVWLNKKlnYISKKTYQGIFSFD---------VLGLQ 134
Cdd:PRK03918 81 GRKYRIVRsfNRGESYlkyldGSEVLEEGDSSVREwverlipyHVFLNAI--YIRQGEIDAILESDesrekvvrqILGLD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 135 DIHKNldEEQLQDYLLEagalgsteftsMRDRIGQKKEELYKKSGKNPIINQQIEQLKQLENQIRNEESKLDTYHRLVDD 214
Cdd:PRK03918 159 DYENA--YKNLGEVIKE-----------IKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 215 KDKSSRRLENLKQNLNQLSKMHEQKQKEVA--------LHDQTQEWKRLEQSL--NIEPINFPEKGIDRYETAKSHKQSL 284
Cdd:PRK03918 226 LEKEVKELEELKEEIEELEKELESLEGSKRkleekireLEERIEELKKEIEELeeKVKELKELKEKAEEYIKLSEFYEEY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 285 ERDKSLREERLSILNKEAESInpvdQKYIDsfnslyqqetEIKQKEFELRSIEKDIADKQRELEALQ-SNIGWQEVFYDT 363
Cdd:PRK03918 306 LDELREIEKRLSRLEEEINGI----EERIK----------ELEEKEERLEELKKKLKELEKRLEELEeRHELYEEAKAKK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 364 DSTEAMKSHMSDLVLGK---------------QEQIAYINQLERGLEENKIERNSNSNEINQVEN-------ELVPDETF 421
Cdd:PRK03918 372 EELERLKKRLTGLTPEKlekeleelekakeeiEEEISKITARIGELKKEIKELKKAIEELKKAKGkcpvcgrELTEEHRK 451
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 488386965 422 EKKKEYTQQVL----ELHEKENLYEKLKETFEEEQTQKNKRQKFLR 463
Cdd:PRK03918 452 ELLEEYTAELKriekELKEIEEKERKLRKELRELEKVLKKESELIK 497
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
282-459 |
8.85e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 39.43 E-value: 8.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 282 QSLERDKSLREERLSILNKEAESINpvdqkyidsfNSLYQQETEIKQKEFELRSIEKDIADKQRELEALQ---------- 351
Cdd:COG3883 26 SELQAELEAAQAELDALQAELEELN----------EEYNELQAELEALQAEIDKLQAEIAEAEAEIEERReelgeraral 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 352 ----SNIGWQEVFYDTDST----------EAMKSHMSDLVLGKQEQIAYINQLERGLEENKIERNSNSNEINQVENELVp 417
Cdd:COG3883 96 yrsgGSVSYLDVLLGSESFsdfldrlsalSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE- 174
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 488386965 418 detfEKKKEYTQQVLELHEKENLYEKLKETFEEEQTQKNKRQ 459
Cdd:COG3883 175 ----AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
3-460 |
9.03e-03 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 39.95 E-value: 9.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 3 IKSLEIYGYGQFVQRKI-EFNRQFTEIFGENEAGKSTIqafIHSILFGFPTKKSKEPRleprlgnqyGGKLS-LIFDDG- 79
Cdd:pfam02463 2 LKRIEIEGFKSYAKTVIlPFSPGFTAIVGPNGSGKSNI---LDAILFVLGERSAKSLR---------SERLSdLIHSKSg 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 80 ---IEAEVERIKGSAHGDVKIYLKDGTIRDEVWLNKKLNY------ISKKTYQGIFS--------FDVLGLQDIHKNL-- 140
Cdd:pfam02463 70 afvNSAEVEITFDNEDHELPIDKEEVSIRRRVYRGGDSEYyingknVTKKEVAELLEsqgispeaYNFLVQGGKIEIIam 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 141 --DEEQLQdylLEAGALGSTEFTSMRDRIGQKKEELYKKSGKNPIINQQIEQLKQLENQIRNEESKLDTyhrlvddkdks 218
Cdd:pfam02463 150 mkPERRLE---IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQL----------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 219 SRRLENLKQNLNQLSKMHEQKQKEVALHDQTQEWKRLEQSLNIEPINFPEKGIDRYETAKSHKQSLERDKSLREERLSIL 298
Cdd:pfam02463 216 KEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEE 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 299 NKEAESINPVDQKYIDSFNSLYQQETEIKQKEFELRSIEKDIADKQRELEALQSNIGWQEVFYD--TDSTEAMKSHMSDL 376
Cdd:pfam02463 296 EELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEelEKLQEKLEQLEEEL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488386965 377 VLGKQEQIAYINQLERGLEENKIERN---SNSNEINQVENELVPDETFEKKKEYTQQVLELHEKENLYEKLKETFEEEQT 453
Cdd:pfam02463 376 LAKKKLESERLSSAAKLKEEELELKSeeeKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEK 455
|
....*..
gi 488386965 454 QKNKRQK 460
Cdd:pfam02463 456 QELKLLK 462
|
|
| |
