|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-382 |
3.22e-91 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 279.11 E-value: 3.22e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 7 VWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTT 86
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 87 MLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVALGAALGGFVAELSFNYIFIANL 165
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 166 LMYVLFAIVAVTQFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDID-ISMSQYSI 244
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILgLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 245 LWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLA 324
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVE--RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488423263 325 PDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVFD 382
Cdd:cd17329 319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-381 |
3.21e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 130.39 E-value: 3.21e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 10 LVIGMALNITGSSFLWPLNTIYMKEeLDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLN 89
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 90 FFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYL-AQNIGVALGAALGGFVAE-LSFNYIFIANLLM 167
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSsAIGLGFLIGPLLGGLLADaLGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 168 YVLFAIVAVTQFNLEYSV--KMHKPDNLELENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQD-IDISMSQYSI 244
Cdd:cd17325 160 ALLALVLALLLLPEPRPPpnKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 245 LWTVNGIMILVAQPLIspVIRILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLA 324
Cdd:cd17325 240 LFGAQGLASALSQPPA--GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488423263 325 PDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-343 |
6.90e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.07 E-value: 6.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTiYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 85 TTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIFI 162
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADlFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 163 ANLLMYVLFAIVAVtqFNLEYSVKMHKPDnlELENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDI-DISMSQ 241
Cdd:COG2814 169 VNAVLALLALLLLL--RLLPESRPAARAR--LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 242 YSILWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIAN 321
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|..
gi 488423263 322 FLAPDGKQGQYQGFVNSASTVG 343
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-348 |
7.49e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.43 E-value: 7.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 10 LVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLN 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 90 FFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIFIANLLM 167
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVsAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 168 YVLFAIVA---VTQFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFSIcWIAYIQWESTIASFTQDIDISMSQYSI 244
Cdd:pfam07690 161 SLLAAVLLllpRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 245 LWTVNGIMILVAQPLISPVI-RILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFL 323
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSdRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 488423263 324 APDGKQGQYQGFVNSASTVGKAFGP 348
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
31-387 |
6.01e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.01 E-value: 6.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 31 YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGM 110
Cdd:COG2271 35 PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 111 IVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIFIANLLMYVLFAIVavtqfnleysvkmh 188
Cdd:COG2271 115 FFPAALKLIAEWFPPKERGRALGIFnAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLALL-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 189 kpdnlelenkdqkrRFKALILLCIMFSICWIAYIQWESTIasFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRILK 268
Cdd:COG2271 181 --------------RFWLLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 269 GNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGP 348
Cdd:COG2271 245 RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324
|
330 340 350
....*....|....*....|....*....|....*....
gi 488423263 349 LIGGILVDAFNMSTMFIGMIVLLSIALCFLAVFDKNMPK 387
Cdd:COG2271 325 LLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-388 |
9.02e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 92.99 E-value: 9.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMALNITGSsfLWPlntiYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTML 88
Cdd:COG0738 17 FFLWGFATALWGP--LIP----ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 89 NFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAELSFN----YIFIAN 164
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhLPYLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 165 LLMYVLFAIVAVTQFNLEYSVKMHKPDNLELENKD--QKRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQY 242
Cdd:COG0738 171 AVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSllKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 243 SILWTVngIMILVAQPLISPVIRILkgNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANF 322
Cdd:COG0738 251 GLSLFW--GGMTIGRFLGGFLLKRF--GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488423263 323 LAPDgKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVFDKNMPKD 388
Cdd:COG0738 327 GLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
39-375 |
1.21e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 92.27 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 39 SLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAM 118
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 119 AGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIFIANLLMyVLFAIVAVTQFNLEYSVKmHKPDNLELE 196
Cdd:cd17489 109 VADIIPPSRRGEGIGYYgLATTLAMALGPALGLFLYQhLGFAVLFIVAAVL-ALLALLLVFLVKDPPPVA-AEEAEAGTR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 197 NKDQKRRFKALILLCIMFSICwIAYiqweSTIASFTQD--IDISMSQYSILWTVNGIMILVAQPLISPVirILKGNIKKQ 274
Cdd:cd17489 187 AFRRLVEKKVLPPALILFLAS-IAY----GAISTFLPLyaAERGISNAGLFFTVYAIALLLSRPFSGKL--SDRKGPKTV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 275 MIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGIL 354
Cdd:cd17489 260 IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
|
330 340
....*....|....*....|...
gi 488423263 355 VDAFNMSTMFI--GMIVLLSIAL 375
Cdd:cd17489 340 AELFGYRAMFLlaAVVVLLALVL 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-378 |
1.03e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.71 E-value: 1.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 30 IYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGG 109
Cdd:cd06174 20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 110 MIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE---LSFNYIFIANLLMYVLFAIVAVtqFNLEYSV 185
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASslgFGWRAVFLIAAALALLAAILLL--LVVPDPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 186 KMHKPDNLELENKDQK------RRFKALILLCIMFSICWIAYIQWESTIASFTQDI-DISMSQYSILWTVNGIMILVAQP 258
Cdd:cd06174 178 ESARAKNEEASSKSVLkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLFGLAGALGSL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 259 LISPVIRILKGnIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNS 338
Cdd:cd06174 258 LLGLLSDRLIG-RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNT 336
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 488423263 339 ASTVGKAFGPLIGG-ILVDAFNMSTMFIGMIVLLSIALCFL 378
Cdd:cd06174 337 FGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-380 |
2.49e-18 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 85.32 E-value: 2.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 10 LVIGMALNITGSSFLWPLNTIYMKEELDKSLT--IAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTM 87
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 88 LNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAelSFNYIFIANLLM 167
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS--TPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 168 YVLFAIVAVTQFnleysvkmhkpdnlelenkdqkRRFKALILLCIMFSICWIAYIQWESTIASFT-QDIDISMSQYSILW 246
Cdd:cd17330 159 AALALLNLVLVL----------------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLkDRFGFSPSQIGLLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 247 TVNGIMILVAQPLISPVIRILKGNiKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPD 326
Cdd:cd17330 217 ALVGIAGILAQLLLIPRLAKRLGE-RKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488423263 327 GKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAV 380
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-379 |
4.77e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.54 E-value: 4.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 32 MKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 112 VPAIYAMAGAVWPNGGRQTFNAIYLAQN-IGVALGAALGGFVAELSFNYIFianLLMYVLFAIVAVTQFNLEYSVKMHKP 190
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLAAISWRYPF---FLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 191 DNLELENKDQKRRFKALILLCIMFS-----ICWIAYIQWESTIASftQDIDISMSQYSILWTVNGIMILVAQPLISPVIR 265
Cdd:cd17474 182 SSSATKLRDLKKALRGRGLLTFLVSaflyfFLYFAFLTYLPFLLE--LLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 266 iLKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKA 345
Cdd:cd17474 260 -KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQA 338
|
330 340 350
....*....|....*....|....*....|....
gi 488423263 346 FGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLA 379
Cdd:cd17474 339 VGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-381 |
3.63e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 76.11 E-value: 3.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 8 WMLVIGMALNITGSSFLWPLNTIYMKEeLDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTM 87
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 88 LNFFHGWPWYAVWLVML-----GFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGF-VAELSFNYI 160
Cdd:cd06173 81 LALLALLGSLSLWLLLVlafllGIASAFFGPARQALLPELVPKEQLVRANALNsLATQLARIIGPALGGLlVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 161 FIANLLMYVLFAIVAVT-QFNLEYSVKMHKPDNLE--LENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDI-D 236
Cdd:cd06173 161 FAINALSFLLSALLLLFiRRPPPAAPGESSSLLLRdlREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 237 ISMSQYSILWTVNGIMILVAqPLISPVIRILKGNIKKqMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAV 316
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRL-LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488423263 317 PTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-176 |
1.55e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.15 E-value: 1.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 4 PKSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLV 83
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 84 STTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIF 161
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDaFGFATPF 357
|
170
....*....|....*
gi 488423263 162 IANLLMYVLFAIVAV 176
Cdd:cd17325 358 LAAAALLLLAAVLFL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-375 |
4.38e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.97 E-value: 4.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 34 EELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVP 113
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 114 AIYAMAGAVWPNGGRQTFNAIYLAQN-IGVALGAALGGFVAE-LSFNYIFIANLLMYVLfaIVAVTQFNLEYSVKMHKPD 191
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLtLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALL--AALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 192 NLELENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWT-VNGIMILVAQPLISPVIRilKGN 270
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLlLFGVAGVVGSPLAGRLAD--RGG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 271 IKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKqGQYQGFVNSASTVGKAFGPLI 350
Cdd:cd17324 263 RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAAL 341
|
330 340
....*....|....*....|....*
gi 488423263 351 GGILVDAFNMSTMFIGMIVLLSIAL 375
Cdd:cd17324 342 GGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-381 |
6.19e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.61 E-value: 6.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 7 VWMLVIGMALNItGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTT 86
Cdd:COG2223 7 LLLATLAFFLAF-GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 87 MLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLA-QNIGVALGAALGGFVAE-LSFNYIFIAN 164
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGgGNLGAAVAAFLAPLLIAaFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 165 LLMYVLFAIVAVTQF-NLEYSVKMHKPDNLelenKDQK-----RRFKALILLCIMFSICWIAYIQWESTIASFTQDIDIs 238
Cdd:COG2223 166 GILLLVVAVLAWLFLrDPPAGAAAAAKASL----RDQLealrdPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 239 msqysilwtVNGIMILVAQPLISPVIRILKGNI-------KKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMF 311
Cdd:COG2223 241 ---------ATAGLLAALFALLGALGRPLGGWLsdriggrRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488423263 312 VWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAF-NMSTMFIGMIVLLSIALCFLAVF 381
Cdd:COG2223 312 GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
197-381 |
2.00e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 70.77 E-value: 2.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 197 NKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRILkgNIKKQMI 276
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 277 VGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVD 356
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*
gi 488423263 357 AFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-144 |
9.02e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 68.85 E-value: 9.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488423263 85 TTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAL 144
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYnSAFFLGGPL 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-381 |
3.41e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 3.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 8 WMLVIGMALNITGSSFLWPLNT----IYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLG---GYRT--ILTGT 78
Cdd:COG2211 9 LKEKLAYGLGDLGLNLAFGLLSayllYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwGRRRpwILIGA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 79 AVCLVSTTMLNFFHGWP------WYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQT--FNAIYLAQNIGVALGAALGG 150
Cdd:COG2211 89 IPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTrlSSWRFAFAGLGGLLASVLPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 151 FVAELSFNYIFIANLLMYVLFAIVAV-----TQFNL-EYSVKMHKPDNLeLENKDQKRRFKALILLCIMFSICWIAYIQW 224
Cdd:COG2211 169 PLVAAFGGDAALGYRLTALIFAVLGLlafllTFFGTkERPVPEEEKVSL-KESLKALLKNRPFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 225 ESTIASFTQD-IDISMSQYSILWTVNGIMILVAQPLISPVIRILKGniKKQMIVGIIIFMVSFLVTSFA--EQFSVFLIG 301
Cdd:COG2211 248 AALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK--KKAFIIGLLLAALGLLLLFFLgpGNLWLLLVL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 302 MIILTFGEMFVWPAVPTIANFLAPDGKQ-------GQYQGFVNSASTVGKAFGPLIGGILVDAFNMS----------TMF 364
Cdd:COG2211 326 AALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsalTGI 405
|
410
....*....|....*..
gi 488423263 365 IGMIVLLSIALCFLAVF 381
Cdd:COG2211 406 RLLFFLLPAVLLLLAAL 422
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
23-377 |
2.01e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 64.65 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 23 FLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLV 102
Cdd:cd17333 13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 103 MLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFV--AELSFNYIFIANLLMYVLFAIVAvtqFN 180
Cdd:cd17333 93 LAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLltSELSWSWAYLIIGLIYLLLAILI---LL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 181 LEYSVKMHKPDNLELENKDQKRRFKAL-ILLCIMFSICWIAYIQWESTIASFTQDI-----DISMSQYSILWTVNGIMIL 254
Cdd:cd17333 170 TLFPELPSARNPQQSVGAFSASASRLLrNPSIILGALALFLYVGAETAFSSWVPSYlvekkHVSDGLAGYLLSGFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 255 VAQPLISPVIRILKgnIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPdGKQGQYQG 334
Cdd:cd17333 250 IGRLLGGPISRRIK--PHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTS 326
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 488423263 335 FVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCF 377
Cdd:cd17333 327 VLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
201-381 |
3.32e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 3.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 201 KRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGII 280
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 281 IFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNM 360
Cdd:COG2271 84 LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180
....*....|....*....|....*..
gi 488423263 361 STMFIGM------IVLLSIALCFLAVF 381
Cdd:COG2271 164 RAAFLILglpgllLALLRFWLLALAYF 190
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-176 |
4.31e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 60.66 E-value: 4.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 85 TTMLNFFHGWPWYAVWLVM-LGFGGGMIVPAIYAMAGAVWPnggrqtfnAIYLAQNIG-VALGAALGGFVAELSFNYIFI 162
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLlLGLALGGGNGAVFALVPDIFP--------TKNAGAVYGlVGAAGGLGGFLGPLLFGALLD 356
|
170
....*....|....*...
gi 488423263 163 A----NLLMYVLFAIVAV 176
Cdd:COG2223 357 AtgsyTAAFLVFAVLALV 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-177 |
5.36e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.27 E-value: 5.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 6 SVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLG--GYRTILTGTAVCLV 83
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 84 STTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAI-YLAQNIGVALGAALGGFVAEL-SFNYIF 161
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLvNTFGFLGGALGPLLVGYLLDAtGYQAAF 340
|
170
....*....|....*.
gi 488423263 162 IANLLMYVLFAIVAVT 177
Cdd:COG2271 341 LLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
209-383 |
8.01e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 8.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 209 LLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRILkgNIKKQMIVGIIIFMVSFLV 288
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 289 TSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMI 368
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*
gi 488423263 369 VLLSIALCFLAVFDK 383
Cdd:pfam07690 159 ILSLLAAVLLLLPRP 173
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
20-381 |
2.31e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 58.36 E-value: 2.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 20 GSSFLWPLNTIYMKEeLDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFF--HGWPWY 97
Cdd:cd17335 12 ALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFvaQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 98 AVWLVMLGFGGGMIVPAIYAMAGAvWPNGGRQTFNAIYLAQNIGVALGAALGGFVAELSFNYI-FIANLLMYVLFAIVAV 176
Cdd:cd17335 91 LLLVILGAFFSAPVVPLVDSITLQ-YLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKnYTIAFYVFAVLMLLAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 177 ---TQFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFSICWIAYiqwESTIASFTQDIDISMSQYSILWTVNGIMI 253
Cdd:cd17335 170 llaLKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLI---YSFLFWHLQDLGGSKTLIGLLWTVGVVSE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 254 LVAQPLISPVIRILKgnIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMII--LTFGEMfvWPAVPTIANFLAPDGKQGQ 331
Cdd:cd17335 247 IPFFFFSSRLIQRFG--HVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLhgLTFALV--WAAAVSYASAAAPPGLRAT 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488423263 332 YQGFVNSAST-VGKAFGPLIGGILVDAFNMSTMFIGMIVLlsiALCFLAVF 381
Cdd:cd17335 323 AQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIA---ALAGLLAF 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-174 |
2.60e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.37 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 3 IPKSVWMLVIGMALNITgSSFLwplnTIYMKEELdksLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCL 82
Cdd:cd17489 197 LPPALILFLASIAYGAI-STFL----PLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 83 VSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLA-QNIGVALGAALGGFVAE-LSFNYI 160
Cdd:cd17489 269 LGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIfFDLGIGLGGLLLGLVAElFGYRAM 348
|
170
....*....|....
gi 488423263 161 FIANLLMYVLFAIV 174
Cdd:cd17489 349 FLLAAVVVLLALVL 362
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-156 |
3.97e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 3.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 4 PKSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLV 83
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 84 STTMLNFFHGWPWYAVWLVM--LGFGGGMIVPAIYAMAGAV-----WPNGGRQT---FNAIYLAQNIGVALGAALGGFVA 153
Cdd:COG2211 307 GLLLLFFLGPGNLWLLLVLAalAGIGLGAILVLPWAMLADVvdydeWKTGRRREglyFGIFTFAIKLGQALAGALAGLLL 386
|
...
gi 488423263 154 ELS 156
Cdd:COG2211 387 ALF 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
201-388 |
4.59e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.58 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 201 KRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRILKGniKKQMIVGII 280
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP--RRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 281 IFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNM 360
Cdd:COG2223 79 LLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180
....*....|....*....|....*...
gi 488423263 361 STMFIGMIVLLSIALCFLAVFDKNMPKD 388
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAG 186
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-175 |
8.16e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.79 E-value: 8.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 85 TTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPnGGRQTFNAIYL-AQNIGVALGAALGGFV-AELSFNYIFI 162
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLaAYNLGGALGAALGGLVlDHGGWAGVGW 356
|
170
....*....|...
gi 488423263 163 ANLLMYVLFAIVA 175
Cdd:cd17324 357 VGAALLLLALLLA 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-374 |
8.79e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 8.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 32 MKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 112 VPAIYAMAGAVWPNGGRQT-FNAIYLAQNIGVALGAALGGFVAE-LSFNYIFIANLLMYVLFAIVAvtqfnleysvkmhk 189
Cdd:cd17321 102 MPASLALIAATFPGERRGRaLGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLINVPIGLVALLLA-------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 190 pdnlelenkdqkRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSqySILWTVNGIMILVAQPLISPVIRilKG 269
Cdd:cd17321 168 ------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA--GLALLPLALAMLVAAPLAGRLAD--RF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 270 NIKKQMIVGIIIFMVSFLVTSFAEQ---FSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAF 346
Cdd:cd17321 232 GPRLVLVAGLLLTAVGLLLLALLGAdssVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
330 340
....*....|....*....|....*....
gi 488423263 347 GP-LIGGILVDAFNMSTMFIGMIVLLSIA 374
Cdd:cd17321 312 GVaLLGALLTAGLSANLGDSGVAALLSAA 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
210-381 |
1.36e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 56.28 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 210 LCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGIIIFMVSFLVT 289
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 290 SFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIV 369
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170
....*....|..
gi 488423263 370 LLSIALCFLAVF 381
Cdd:cd06174 159 AALALLAAILLL 170
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
7-178 |
1.83e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 55.70 E-value: 1.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 7 VWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTT 86
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 87 MLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFVAE-LSFNYIFIAN 164
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLA 369
|
170
....*....|....
gi 488423263 165 LLMYVLFAIVAVTQ 178
Cdd:cd06173 370 GALLLLAALLLLLL 383
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
9-148 |
2.27e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMALNitGSSFLWPLntiYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTML 88
Cdd:cd17503 187 SFLLGLGLF--GAMFLLPL---YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLL 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488423263 89 NFFH---GWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAAL 148
Cdd:cd17503 262 AFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTAL 325
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
59-378 |
2.54e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.24 E-value: 2.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 59 LLGGSLFDKLGGY-RTILTGTAVCLVSTTMLNFFHGWPWyAVWLVMLG-FGGGMIVPAIYAM-AGAVWPNGGRQTFNAIY 135
Cdd:cd17370 52 LFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQL-VLLLRILErLGKGIRTPPRDALlADATPPSGRGKAFGLHR 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 136 LAQNIGVALGAALGGFV---AELSFNYIFIANLLMYVLfAIVAVTQFNLEYSVKMHKPdnLELENKDQKRRFKALILLCI 212
Cdd:cd17370 131 ALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPALL-ALLILLFVVKEYPRPPKLR--KKSKKTSLKKLPKAFWLYLL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 213 MFSICWIAYIQWeSTIASFTQDIDISMSQYSILWTVngimILVAQPLISPVIRIL--KGNIKKQMIVGIIIFMVSFLVTS 290
Cdd:cd17370 208 AVALFALGNFSF-AFLILRAQELGLSAALIPLLYAL----FNLVYALAAYPAGRLsdRIGRKKLLILGYLSLALAYLGFA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 291 FAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVL 370
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
....*...
gi 488423263 371 LSIALCFL 378
Cdd:cd17370 363 ALIALLLL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
231-389 |
3.70e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.86 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 231 FTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRILkgNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEM 310
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI--ERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488423263 311 FVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVFDKNMPKDK 389
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-381 |
4.31e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.50 E-value: 4.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 31 YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFG-GG 109
Cdd:cd17319 28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 110 MIVPAIYAMAgaVW-PNGGRQTFNAIYL-AQNIGVALGAALGGFVAEL-----SFNYIFIANLLMYVLFAIVAvtqfnle 182
Cdd:cd17319 108 FFPGAIKALA--EWfPARERGRATGLFNsGAPLGAAIGPPLSGWLLLLfgwrwAFIIEGLLGLLLAVLWWFYL------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 183 ysvkmhkpdnlelenkdqkRRFKALILLCIMFSICWIAYIQWESTIasFTQDIDISMSQYSILWTVNGIMILVAQPLISP 262
Cdd:cd17319 179 -------------------RQVWGLALGYFGINYALYGLLTWLPTY--LKQARGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 263 VI-RILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSAST 341
Cdd:cd17319 238 LSdRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGN 317
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 488423263 342 VGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:cd17319 318 LGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
32-177 |
5.94e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.66 E-value: 5.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 32 MKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488423263 112 VPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIFIANLLMYVLFAIVAVT 177
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWgAAIGLGLALGPLLGGLLVAaLGWRWIFLINAPLGLLALVLRLR 187
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-381 |
6.76e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.11 E-value: 6.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 7 VWMLVIGMALNITGSSFLWPLntiyMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTT 86
Cdd:COG2807 23 IVLVALNLRPAITSVGPLLPE----IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 87 MLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGgRQTFNAIY-LAQNIGVALGAALGGFVAE-LSFNYIFIAN 164
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYtAAMGLGAALAAGLTVPLAAaLGWRGALAVW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 165 LLMYVLFAIVAVTQFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFSICWIAYIQWestIASFTQDIDISMSQYSI 244
Cdd:COG2807 178 ALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAW---LPPILRDAGLSAATAGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 245 LWTVNGIMILVAQPLISPVIRILkGNIKKQMIVGIIIFMVSFLVTSFAEQfSVFLIGMIILTFGEMFVWPAVPTIANFLA 324
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRL-GDRRPLLLLLGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488423263 325 PDGKQ-GQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:COG2807 333 RTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-380 |
7.26e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 53.73 E-value: 7.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 41 TIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAG 120
Cdd:cd17473 35 LLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 121 AVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAELSFNYIFIANLLMYVLFAIVAVTQFNLEYSVKMHKPDNLELENKD 199
Cdd:cd17473 115 DYFEGEERAKMLGLQsAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 200 QKRRFKAL-ILLCIMFSICWIAYIQwestIASFTQDIDI-SMSQYSILWTVNGImilvAQPLISPVIRILKGNIKKQMIV 277
Cdd:cd17473 195 PWKRVLPIyFLAFLAMLLFYVIPIQ----LPFLLQERGGgSAALIGLALAIASL----AGAIGALLFGRLKRRLGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 278 GI--IIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILV 355
Cdd:cd17473 267 AIgfALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346
|
330 340
....*....|....*....|....*..
gi 488423263 356 DAFN--MSTMFIGMIVLLSIALCFLAV 380
Cdd:cd17473 347 NLTGglSGAFLILGVLALVLAIVLLLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
199-375 |
9.70e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 9.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 199 DQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVirilkGNI---KKQM 275
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRL-----GDRygrKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 276 IVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILV 355
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180
....*....|....*....|
gi 488423263 356 DAFNMSTMFIGMIVLLSIAL 375
Cdd:COG0477 163 AALGWRWIFLINAPLGLLAL 182
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
29-381 |
1.44e-07 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 52.96 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 29 TIYMKEELDKSLTIAGIVLMINSF-GMV-VGNLLGGSLFDK-LGGYRTILTGTAVCLVSTTMLNFFHGWPWYA-VWLVML 104
Cdd:cd17346 26 ILYLTAQLGDGFSEADAASIYGAYtALVyLTPIIGGWLADKvLGARRTVFIGGILMALGYLLLALSPFSVSMLyLGLALI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 105 GFGGGMIVPAIYAMAGAVWPNGGRQT---FNAIYLAQNIGVALGAALGGFVAE-LSFNYIFianllmYVLFAIVAVTQFN 180
Cdd:cd17346 106 IVGNGLFKPNISSLVGKLYDENDPRRdsgFSIFYMGINLGAFLAPLLCGTLGDnYGYHYGF------GLAAVGMLLGLLI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 181 LEYSVKMHKpdnlelenkdQKRRFKALILLCIMFSICWIAYIQWESTIASFTQD--------IDISMSQYSILwtvNGIM 252
Cdd:cd17346 180 FLLGRKKLL----------ERKKMLAIIILFLFAVVFWAIYEQAGTSLALFADEnvdrllggFTIPPSWFQSL---NPLF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 253 ILVAQPLISPVIRILKG-----NIKKQMIVGIIIFMVSFLVTSFAEQFSV--------FLIGMIIL-TFGEMFVWPAVPT 318
Cdd:cd17346 247 IILLAPILAALWTKLGKrgkdpSIPTKFALGLLLLGLSFLLMVLAASFAGgsgkvsalWLVLSYFLqTLGELCLSPVGLS 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488423263 319 IANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGI------LVDAFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:cd17346 327 MITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFyaqpkdPLASALVYTDYFGLIGVIALVAGIILLL 395
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-380 |
2.67e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 27 LNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGF 106
Cdd:cd17316 22 APVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 107 GGGMIVPAIYAMAGAVWPNGGRQTFNAIYLAqniGVALGAALGGFVAeLSFNYIFIANLLMYVLFAIVAVTQFNLEYsvk 186
Cdd:cd17316 102 GIGGEYPGASTYVAEFAPSKRRGFALGLLQS---GWALGALLAALVA-SLLIPLLSGDWGWRILFLIGALPALLALL--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 187 mhkpdnlelenkdQKRRFKALILLCIMFSICWIAYIQWESTIasFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRI 266
Cdd:cd17316 175 -------------LRRRTLLLILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 267 LkgNIKKQMIVGIIIFMVS--FLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGK 344
Cdd:cd17316 240 I--GRKKTLVIGLILSGILalPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 488423263 345 AFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAV 380
Cdd:cd17316 318 GGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
200-381 |
4.46e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 4.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 200 QKRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRILkgNIKKQMIVGI 279
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 280 IIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDgKQGQYQGFVNSASTVGKAFGPLIGGILVdAFN 359
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLI-LLG 158
|
170 180
....*....|....*....|..
gi 488423263 360 MSTMFIGMIVLLSIALCFLAVF 381
Cdd:COG0738 159 LSLSWHLPYLILAVLLLLLALL 180
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
10-379 |
7.28e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 10 LVIGMALNITGSSFLWPLNTIyMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLN 89
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 90 FFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVwPNGGRQTFNAIY-LAQNIGVALGAALGGFVAELSFNYIFIANLLMY 168
Cdd:cd17478 80 FAPNYWLLLLLVALAGIGSAAFHPEGARLASQA-AGGRRGLAMSIFsVGGNLGFALGPLIAAALVALFGGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 169 VLFAIVAVTQFNLEYSVKMHKPDNLELENKDQKRRFKALILL-CIMFSICWIAYiqwestiasftqdidiSMSQY-SILW 246
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLlIIVFLRSWVLS----------------SLTTFlPFYL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 247 TVNGIMILVAQPLISpvIRILKGNI--------------KKQMIVGIIIFMVSFLVTSFAEQFSVFlIGMIILTFGEMFV 312
Cdd:cd17478 223 VQRGYSLVFAGLLLS--LFLFAGAIgtliggplsdrfgrRRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFAS 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 313 WPAVPTIANFLAPDGK---QGQYQGFVNSAStvgkAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLA 379
Cdd:cd17478 300 FPVTVVLAQELLPGNVglaSGLMMGLSFGLG----GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
59-359 |
9.94e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.34 E-value: 9.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 59 LLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQT--FNAIYL 136
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNivFSLFGA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 137 AQNIGVALGAALGGFVAEL-SFNYIFIANLLMYVLFAIVAVTQFNleysvkmhkpdnlelenkdqkrRFKALILLCIMFs 215
Cdd:cd17476 131 TAPLGFALGGVFGGLFAQLaWWPWIFWFLAILAAIVAVAAIFWTS----------------------PSFIAVLLAVFL- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 216 iCWIAYIQWESTIASFTQDID-ISMSQYSILWTVNGIMILVAQPLISPVIRILKGNikKQMIVGIIIFMVS--FLVTSFA 292
Cdd:cd17476 188 -GWASFGIWVFYATQYFQNVRgYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPS--YIMAISMVAFLVGpiLFATMPV 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488423263 293 EQ--FSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFN 359
Cdd:cd17476 265 HQtyWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTVETSVN 333
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
245-370 |
2.01e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.52 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 245 LWTVNGIMILVAQPLISPVIRIL-KGNIKKQMIVGIIIFM-VSFLVTSFAE-QFSVFLIGMIILTFGEMFVWPAVPTIAN 321
Cdd:cd17472 231 LWKVYLPAILIGFILMVPFVIYAeKKGKMKQVFVSSILLIaVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSLVS 310
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 488423263 322 FLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVL 370
Cdd:cd17472 311 KIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILIL 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
5-152 |
2.26e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.09 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488423263 85 TTMLNFFH---GWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFV 152
Cdd:cd17321 248 LLLLALLGadsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILnTARQLGGALGVALLGAL 319
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
9-179 |
2.46e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.19 E-value: 2.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMALNITGSSFLwPLNTIYMKE---ELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILtgtaVCLVST 85
Cdd:cd17391 206 LFVTTFIIQLANQSIE-PILTLYIRQlmgDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILL----GALLAS 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 86 TMLNF---FHGWPWYAVWLVML-GFGGGMIVPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFV-AELSFNY 159
Cdd:cd17391 281 ALLYIpqaFVQTPWQLGILRFLlGLATGGLLPAINSLLAKITPKEVAgRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRA 360
|
170 180
....*....|....*....|
gi 488423263 160 IFIANLLMYVLFAIVAVTQF 179
Cdd:cd17391 361 VFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
23-381 |
2.86e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.79 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 23 FLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWL- 101
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLg 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 102 VMLGFGGGMIVPAIYaMAGAVWPNGGRQTFNAIYL-AQNIGVALGAALG----GFVAELSFNYIFIANLLMYVLFAIVAV 176
Cdd:cd17341 96 FLLGFAGANFASGQP-WASFWFPKEKIGGAAGGIAgAGNMGVAVSQLLApliaGAIVFDGGFVGWRNAFFVPGILLAIAA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 177 TQFNLEYSVKMHKPDNLELENKDQKRRFK--ALILLCIMFSICWIAYIQWESTIASFTQDI-DISMSQYSILWTVNGIMI 253
Cdd:cd17341 175 VLVLLFGDDLPTGKASALEFLKVQLAVLKnyRTWILSLLYGVTFGSFVGFSNVLPTYFKTRfGLPLVTAGILAALFPLAG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 254 LVAQPL---ISPVIRILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPdGKQG 330
Cdd:cd17341 255 ALARPAggwLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFR-RELG 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488423263 331 QYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIgMIVLLSIALCFLAVF 381
Cdd:cd17341 334 AVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAF-SLFGVLAVACTLLVW 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
272-378 |
3.63e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.36 E-value: 3.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 272 KKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIG 351
Cdd:cd17489 61 KRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140
|
90 100
....*....|....*....|....*....
gi 488423263 352 GILVDAFNMSTMFI--GMIVLLSIALCFL 378
Cdd:cd17489 141 LFLYQHLGFAVLFIvaAVLALLALLLVFL 169
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
272-382 |
3.66e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 3.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 272 KKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIG 351
Cdd:cd17503 61 RRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLG 140
|
90 100 110
....*....|....*....|....*....|.
gi 488423263 352 GILVDAFNMSTMFIGMIVLLSIALCFLAVFD 382
Cdd:cd17503 141 GWLTDNLSWRWIFYINLPIGILALLLAPLLD 171
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-175 |
4.35e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 4.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 10 LVIGMALNITGSSFLWPLNTI---YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTT 86
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFlptYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 87 --MLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTfnAIYLAQNIGVALGAALGGFVAELSFNYIFIAN 164
Cdd:cd17316 259 plFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT--GVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
170
....*....|.
gi 488423263 165 LLMYVLFAIVA 175
Cdd:cd17316 337 PALILALLAIV 347
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
8-375 |
5.07e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.00 E-value: 5.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 8 WMLVIGMALNITGSSFLWPLntiyMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTM 87
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPF----LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 88 LNFFHGWPWYAVWLVMLGFGGGMIVPA-IYAMAGAVWPN------GGRQTfnaiylAQNIGVALGAALGGFVAE-LSFNY 159
Cdd:cd17475 78 MALVGSYPVLLVLLFLVGAGYGSVQPGgGRAIMRWFPPRerglamGIRQT------GVPLGGALAAALLPPLALhYGWRA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 160 IFIANLLMYVLFAIVAVTqFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFSICWIAYIQWesTIASFT-----QD 234
Cdd:cd17475 152 AFVVAGLVSILAAVLFWL-FYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQF--ALLTFLllflhDH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 235 IDISMSQYSILWTV---NGIMILVAQPLISPviRILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMF 311
Cdd:cd17475 229 LGLSVVAAGALLAVaqlGGALGRIGLGRVSD--RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488423263 312 V--W--PAVPTIANfLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDA---FNMSTMFIGMIVLLSIAL 375
Cdd:cd17475 307 AigWngLYLTLVAE-SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAthsYAPAWLALALLLVLAALL 376
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-378 |
6.18e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.94 E-value: 6.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 10 LVIGMALNITGSSFLWPLNTIYMKEElDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLN 89
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 90 FFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAELSFNYIFIANLLMy 168
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYsTVLGLGFALGPLLLALVGTAGALPFLIAAVLL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 169 vLFAIVAVTqfnleySVKMHKPDNLELENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTV 248
Cdd:cd17477 159 -LLALVPLL------LTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 249 NGIMILVAQPlisPVIRILKGNIKKQMIVGI-IIFMVSFLVTSFAEQFSVFLIGMIILTFGEMF-VWPAVPTIANFLAPD 326
Cdd:cd17477 232 FVLGGLLLQW---PLGWLADRFDRRRVLLGCaLLGALAALLLPLVPGLPLALLVLLFLWGGAAGpLYTLALALAGDRLPG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 488423263 327 GKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFL 378
Cdd:cd17477 309 DELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
44-381 |
1.10e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.87 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 44 GIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVW 123
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 124 PNGGRQTFNAIYLAQNIGVALGAALGGFVAELSFnYIFIANLLMYVLFAIVAVT--QFNLEYSVKMHKPDNLELENKDQK 201
Cdd:cd17393 117 RAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGV-SPGVHLLAAAVLLLLAALVaiRALLPGTGEAAEDRPDGAGKPGFL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 202 RRFKALILLCIMfsiCWIAYIQwESTIAS-----FTQDIDISMSQYSILWTVNGIMILVAQPL-------ISPVIRILKG 269
Cdd:cd17393 196 LPNRLLLLLGLL---ALAAALA-EGAAADwsalyLRDVLGASAALAALGYAVFSLAMTVGRLFgdrlvdrFGDVAVLRAG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 270 nikkqMIVGIIifmvSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPdGKQGQYQGFVNSASTVGKAFGPL 349
Cdd:cd17393 272 -----ALLAAL----GLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPG-LAAGIAVARVATLGYLGFLVGPP 341
|
330 340 350
....*....|....*....|....*....|..
gi 488423263 350 IGGILVDAFNMSTMFiGMIVLLSIALCFLAVF 381
Cdd:cd17393 342 LIGFLADATGLRTAF-LVVALLALLVALLARA 372
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
26-154 |
1.55e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.46 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 26 PLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFF--HGWPWYAVWLVM 103
Cdd:cd17318 41 KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRIL 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 488423263 104 LGFGGGMIVPAIYAMAgAVW--PNGGRQTFNAIYLAQNIGVALGAALGGFVAE 154
Cdd:cd17318 121 QGLAQGVTFPAMHALW-AKWapPLERSRLTSIAYSGSQFGTVIAMPLSGFLCE 172
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
5-176 |
3.89e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 85 TTMLNFFHG-WPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE--LSFNYI 160
Cdd:cd06174 283 GLALLLLAPsLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLnTFGFLGGAIGPLLAGFLLAatFGLTGA 362
|
170
....*....|....*.
gi 488423263 161 FIANLLMYVLFAIVAV 176
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-381 |
4.60e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 4.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMALNITGSSFLWPLNtiymkEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGT---AVCLVST 85
Cdd:cd17355 11 ILILSWGIRYYFGVFIIPII-----AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLlllAAGLVLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 86 TMLNffHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQT-----FNAIYLAQNIGVALGAALggfVAELSFNYI 160
Cdd:cd17355 86 ALAT--SLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLalgilTAGGGLGSLVFLPLGAAL---IEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 161 FIANLLMYVLfAIVAVTQFNLEYSVKMHKPDNLELENKDQKRRFKALI------LLCIMFSICWIAYIQWESTIASFTQD 234
Cdd:cd17355 161 LLVLALLALL-VLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALrsasfwLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 235 IDISMSQYSILWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILtFGemFVWP 314
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGD--RYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAAL-FG--LGWG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488423263 315 AVPTIANFLA----PDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:cd17355 315 ATVPLTAALAaryfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
43-153 |
5.32e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 43 AGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAV 122
Cdd:cd17365 36 LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEY 115
|
90 100 110
....*....|....*....|....*....|.
gi 488423263 123 WPNGGRQTFNAIYLAqniGVALGAALGGFVA 153
Cdd:cd17365 116 APARRRSLAVTLMFC---GYPLGAALGGFLA 143
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
9-385 |
5.50e-05 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 44.89 E-value: 5.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMALNITGSSfLWPlntiYMKEeLDKSLTIA--GIVLMINSFGMVVGNLLGGSLFDKLGGYRTIL-TGTAVCLVST 85
Cdd:cd17326 8 MFLSSLQFSIVLTS-IWP----YLQK-IDPTATASffGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLiVSILIAIVGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 86 TMLNFFHGWPWYAVWLVML-----GFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAELSF--- 157
Cdd:cd17326 82 ILYALAEYFPSNRKYVMLVarfliGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYpgy 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 158 NYIFIANLLMY----VLFAIVAVTQFNLEYSVkmhkpdnlelenkdqkrrFKALILLCIMFSICWIAYIqWESTIASFTQ 233
Cdd:cd17326 162 VIGIKLRFNMYtapaWLMAILGIINIILILFF------------------FKEVVCIFLFFVVLFIFAN-LETIGTPLTM 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 234 DI-----DISMSQYSILWTVNGIMILVAQPLISPvIRILKGNIKKQMIVGIIIFMVSFLVTsfaeqFSVFLIGMIILTFG 308
Cdd:cd17326 223 DMygwtrEEAVLYNGIILAVSGVLSVLVFLLFKF-LSLGLIDERKILLGGLILFFLGFVVT-----LPWGITGVILFGLG 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488423263 309 EMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFLAVFDKNM 385
Cdd:cd17326 297 YPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
231-389 |
5.70e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 5.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 231 FTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEM 310
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLAD--RKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 311 FVWPAVPTIANFLAPdGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFI-GMIVLLSIALCFLAVFDKNMPKDK 389
Cdd:cd17478 100 AFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLIlLIIPGLAVALLLLRLRPLKKPEAK 178
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
31-364 |
6.93e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.67 E-value: 6.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 31 YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGM 110
Cdd:TIGR00881 20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 111 IVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAELSFNY--IFIANLLMYVLFAIVAV----------- 176
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPLVLFGIAELYSWhwVFIVPGIIAIIVSLICFlllrdspqscg 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 177 -TQFNLEYSVKMHKPDNLELENKDQKRRF-------KALILLCI----MFSICWIaYIQWESTIASFTQDID-ISMSQYS 243
Cdd:TIGR00881 180 lPPAEEMPNEEPDGDAEKKEEELTKKQIFlqyvllnKVLWYISLgyvfVYVVRTG-ILDWSPLYLTQEKGFSkEKASWAF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 244 ILWTVNGIM-ILVAQPLISPVIRILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMII--LTFGEMFVWpavPTIA 320
Cdd:TIGR00881 259 TLYELGGLVgTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALgfLVYGPQMLI---GVIA 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 488423263 321 NFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMF 364
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
39-175 |
7.10e-05 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 44.70 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 39 SLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAM 118
Cdd:PRK10091 233 SETSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFICCAGLFALSAPLQI 312
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488423263 119 AGAVWPNGGRQTFNA-IYLAQNIGVALGAALGGFVAELSFNYIFIANLLMYVLFAIVA 175
Cdd:PRK10091 313 LLLQNAKGGELLGAAgGQIAFNLGSAIGAYCGGMMLTLGLAYNYVALPAALLSFAAMS 370
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
9-378 |
1.19e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMAlnitgSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTML 88
Cdd:cd17471 5 TLLTGLA-----GAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 89 --NFFHGWPWYAVWLVMLGFGGgMIVPAIYAMA--GAVWPNGGRQTF------NAIYLAQNIGVALGAALggfVAELSFN 158
Cdd:cd17471 80 faFLRNYWVLLLVGVVLLSLGA-AAFPQLFALAreYADRSSGRDATLfnsvlrAAFSLAWVIGPPLAFLL---LDVLGFT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 159 YIFianLLMYVLFAIVAVTQFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFSICWIAyiQWESTIAS---FTQDI 235
Cdd:cd17471 156 GLF---LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAA--NSMYIIAMplyVTNEL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 236 DISMSQYSILWTVNG-----IMILVAqplispvIRILKGNIKKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEM 310
Cdd:cd17471 231 GGSESWVGLLFGLAAaleipIMLLAG-------LLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488423263 311 FVWPAVPTIANFLAPdGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMFIGMIVLLSIALCFL 378
Cdd:cd17471 304 ITAGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
4-176 |
1.23e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.79 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 4 PKSVWML-VIGMALNIT-GSSFLWplNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVC 81
Cdd:cd17393 198 NRLLLLLgLLALAAALAeGAAADW--SALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 82 LVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAE---LSFN 158
Cdd:cd17393 276 ALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADatgLRTA 355
|
170
....*....|....*...
gi 488423263 159 YIFIANLLMYVLFAIVAV 176
Cdd:cd17393 356 FLVVALLALLVALLARAV 373
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
24-365 |
1.26e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 43.77 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 24 LWPLNTIYMK-EELDKSLTiaGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILT----GTAVCLVSTTMLNFFHGWPWYA 98
Cdd:pfam12832 18 LLPYWGLYLRsIGLNPSEI--GLITAILPLTRILAPPIWGWLADRTGKRKAVVRlasiLAAVLFLSVLFIPISLTFWWLA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 99 VWLVMLGFGGGMIVPaIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAEL-SFNYIFIANLLMYVLFAIVAVT 177
Cdd:pfam12832 96 LLVVLFSFFWNAILP-QFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHySVGLLPSVLFYLFAALMLLSLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 178 QFNLEYSVKMHKPDNLELENKDQKRRFKALILLCIMFsICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQ 257
Cdd:pfam12832 175 LPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAF-LLGFSHGPFYTFLFLYLENLGASNTLLGALWALGVVAEIPLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 258 PLISPVIRILkgNIKKQMIVGIIIFMVSF-LVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFV 336
Cdd:pfam12832 254 FYAHRLLRRF--GHRNLLIIALLLTALRWlLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALY 331
|
330 340 350
....*....|....*....|....*....|
gi 488423263 337 NSAS-TVGKAFGPLIGGILVDAFNMSTMFI 365
Cdd:pfam12832 332 SGLYfGLGGALGSLIGGQLWDLFGARFTFR 361
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
43-153 |
1.86e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 43 AGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAV 122
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133
|
90 100 110
....*....|....*....|....*....|.
gi 488423263 123 WPNGGRQTFNAIYLaqnIGVALGAALGGFVA 153
Cdd:TIGR00895 134 APKRFRGTAVGLMF---CGYPIGAAVGGFLA 161
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
9-175 |
2.36e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.95 E-value: 2.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 9 MLVIGMALNITGSSFLWPLNTIYMkeeLDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTML 88
Cdd:cd17504 188 LAGFGMFMVFQLLPQLLQLPTPTG---FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 89 NFFHGWPWYAVWLVML-GFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFV-------------- 152
Cdd:cd17504 265 ALLHSSLWALVVALLLiGIGLGLAFASLPNIVVESVPPDRTGIATGMNtVLRTIGSAIGPAIAGAIlttytvsitsggvp 344
|
170 180
....*....|....*....|...
gi 488423263 153 AELSFNYIFIANLLMYVLFAIVA 175
Cdd:cd17504 345 TEGAYVLAFLIGAALALAALLLS 367
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
14-178 |
3.57e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 42.99 E-value: 3.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 14 MALNITGSSFLWPLNTI-------YMKEELDKSLTI-AGIVLMINSFGMVVGNLLGGslfdKLGGyRTILTGT----AVC 81
Cdd:PRK08633 234 LWLAIIGLSYFWFISQLaqanfpaYAKEVLGLDNTFqVQYLLAASAIGIGIGSLLAG----RLSG-RHIELGLvplgALG 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 82 LvsTTMLNFFHGWP---WYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFVA--EL 155
Cdd:PRK08633 309 L--ALSLFLLPTAPslaSVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELgKVLAANNFLQNVGMLLFLALTTLFSglGL 386
|
170 180
....*....|....*....|...
gi 488423263 156 SFNYIFIANLLMYVLFAIVAVTQ 178
Cdd:PRK08633 387 SPAGLFYLIALVTLIGTLYTLLL 409
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
134-375 |
4.14e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.21 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 134 IYLAQNIGVALGAALGGFVAE-LSFNYIFianlLMYVLFAIVA-VTQFNLEYSVKMHKPDNLELENKDQKRRFKALILLC 211
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEhFGMRAPF----LLAALAGVLGfILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFS 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 212 IMFSICWiaYIQWeSTIASFTQDI--DISMSQYSILWTVNGIMIL-VAQPLISPVIRILKGNIKKQMIVGIIIFMVSFLV 288
Cdd:cd17490 201 LLAILQQ--MITF-STTFGFTPLIakQLGASSFQLGLLSIIYLLPnALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 289 TSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMSTMF--IG 366
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFfvIG 357
|
....*....
gi 488423263 367 MIVLLSIAL 375
Cdd:cd17490 358 VIALLAAIL 366
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-177 |
5.60e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGmalNITGSSFLWPLNT---IYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYR---TILTGT 78
Cdd:cd17319 179 RQVWGLALG---YFGINYALYGLLTwlpTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 79 AVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMIVPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAEL-- 155
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLInSGGNLGGFVAPLLIGYLVDAtg 335
|
170 180
....*....|....*....|..
gi 488423263 156 SFNYIFIANLLMYVLFAIVAVT 177
Cdd:cd17319 336 SYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
32-381 |
6.21e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 32 MKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 112 VPAIYAMAGAVWPNGGRQTFNA-IYLAQNIGVALGAALGGFVAE-LSFNYIFIANLLMYVLFAIVAVTQFNlEYSVKMHK 189
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSlLMMILAIAPALAPLLGGLLLLfFGWRAIFVFLALLGLLLLLLVLLFLP-ETLPEEKR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 190 PDNLELENKDQK-----RRFKALILLCIMFSICWIAYIqwesTIASF--TQDIDISMSQYSILWTVNGIMILVAQPLISP 262
Cdd:cd17320 184 KPLLSSLLRAYKrvlknRRFLGYALALGLSFAGLFAYL----AAAPFiyIEQLGLSPAQFGLLFALNAIALILGSLLNGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 263 VIRILKgnIKKQMIVGIIIFMVS---FLVTSFAEQFSV--FLIGMIILTFGEMFVWPAVPTIAnfLAPDGKQ-GQYQGFV 336
Cdd:cd17320 260 LVRRFG--PRRLLRLGLLLLLAAalvLLLAALLGGLSLwpLVAPLFLIFFGFGLIFPNATSLA--LEPFPHVaGTASALL 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488423263 337 NSASTVGKAFGPLIGGILVDaFNMSTMFIGMIVLLSIALCFLAVF 381
Cdd:cd17320 336 GFLQFLIGALAGALVGLLPN-GTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
30-176 |
8.23e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.01 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 30 IYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYR-TILTGTAVCLVSTTMLNFFH---GWPWYAVWLVMLG 105
Cdd:cd17502 192 LYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVGAGLLTTLTldtSKWLLIGYLILLG 271
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488423263 106 FGGGMIVPA-IYAMAGAVWPNGGRQTFNAIYLAQNIGVALGaalggfvaeLSFNYIFIANLLMYVLFAIVAV 176
Cdd:cd17502 272 LGLGIGFQQpLVAVQNAVPPADVGVATATNTFFRSLGGTLG---------VAITDVFLVALALAALAFLLSL 334
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
44-380 |
1.09e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 40.70 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 44 GIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHgwpwyAVWLVMLGFGGGMIVPAIYAMAGA-- 121
Cdd:cd17388 41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP-----TLWWLYLGRIIAGITGATGAVAAAyi 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 122 --VWPNGGR-QTFNAIYLAQNIGVALGAALGGFVAELSFNYIFIA----NLLMYVLFAIVAVTQFNLEYSVKMHKPDNLE 194
Cdd:cd17388 116 adVTPPEQRaRNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVaaglNGLNFLLGLFVLPESLPPERRRAFRWRRANP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 195 LENKDQKRRFKALILLCIMFSICWIAYIQWESTIASFTQD-IDISMSQYSILWTVNGIMILVAQP-LISPVIRILkgNIK 272
Cdd:cd17388 196 FGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDrFDWSPTMVGLSLAVFGLLHALFQAfVTGPIAKRL--GEK 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 273 KQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMfVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGG 352
Cdd:cd17388 274 RAILLGLAADALGFLLLAFATQGWMVFPILILLALGGI-AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFT 352
|
330 340
....*....|....*....|....*...
gi 488423263 353 ILVDAFnmSTMFIGMIVLLSIALCFLAV 380
Cdd:cd17388 353 GIFAAS--PATWPGLAWIIGAALYLICL 378
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
39-376 |
1.37e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 40.66 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 39 SLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVML-------GFGGGMI 111
Cdd:cd17385 32 SDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRVPDGTVFIALCflvriveAVGFAAF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 112 VPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAElSFNYIFIANLLMYVLFAIVAVTQFNLeysvkmhkPD 191
Cdd:cd17385 112 ITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQ-AGGYELPFLVLGCLLLLTVPLNMFIL--------PR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 192 NLELENKDQKRRFKALILLCIMFSIcwiAYIQWESTIASFtqdIDISMSQYSILWTVN----GIMILVAQ---PLISPVI 264
Cdd:cd17385 183 YDDDPSPKSGSMLKLLKIPSVLLLC---LSIVSGSVSLGF---LDPTLSPHLRQFKLSpgqvGLMFLILAgsyAISAPLW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 265 RIL--KGNIKKQMIV-GIIIFMVSFL------VTSFAEQFSVFLIGMIILTFGEMFVwpAVPTIANFLA-------PDG- 327
Cdd:cd17385 257 GWLsdKKKIPKWLMViGSIITGVGFLllgpapLLPIKSELWMVIIGLVLLGLSLGAA--LVPTFPELLNcareygfPDNl 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 488423263 328 -KQGQYQGFVNSASTVGKAFGPLIGGILVDA--FNMSTMFIGMIVLLSIALC 376
Cdd:cd17385 335 sTYGLVSGLFNAAFSLGAFIGPTLGGFLLERlgFEWAATIQAGLAFVVGILM 386
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
31-119 |
1.48e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 31 YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWLVMLGFGGGM 110
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL 302
|
....*....
gi 488423263 111 IVPAIYAMA 119
Cdd:cd17473 303 LLPTLNSWA 311
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
203-380 |
1.48e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.25 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 203 RFKALILLCIMFSICWIAYIQWESTIASFTQDIDISMSQYSILWTVNGIMILVAQPLISPVIRilKGNIKKQMIVGIIIF 282
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLD--RFGARKVLAVSMLLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 283 MVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGILVDAFNMST 362
Cdd:cd17319 79 SLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW 158
|
170 180
....*....|....*....|
gi 488423263 363 MFI--GMIVLLSIALCFLAV 380
Cdd:cd17319 159 AFIieGLLGLLLAVLWWFYL 178
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
12-154 |
1.57e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 40.48 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 12 IGMALNITGSSFLWPLNtIYmkeeldkSLTIAGIVLMInsfgmvvgnllgGSLFDKLGGYRTILTGTAVCLVSTTMLNFF 91
Cdd:PRK14995 32 LSMTLGASGNELLWIID-IY-------SLVMAGMVLPM------------GALGDRIGFKRLLMLGGTLFGLASLAAAFS 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488423263 92 HGWPWYAVWLVMLGFGGGMIVPAIYA-------------MAGAVWPNGGrqtfnaiylaqNIGVALGAALGGFVAE 154
Cdd:PRK14995 92 PTASWLIATRALLAIGAAMIVPATLAgiratfteekqrnMALGVWAAVG-----------SGGAAFGPLVGGILLE 156
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-153 |
1.93e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.98 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 31 YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWYAVWlvmLGFGGGM 110
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILI---LGFPLGF 311
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 488423263 111 IVPAIYAMAGA----VWPNGGRQT-FNAIYLAQNIGVALGAALGGFVA 153
Cdd:cd17371 312 FASGPFSGMGAylteLFPTAVRATaQGFCYNVGRIIGALFPFLVGFLA 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
5-175 |
2.56e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 5 KSVWMLVIGMALNITGSSFLWPLNTIYMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVS 84
Cdd:cd17353 213 PTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 85 TTMLNFF-HGWPWYAVWLVMLGFGGGmivpAIYAMAgavwPNGGRQTFNAIYLAQNIGV-----ALGAALGGFVA----- 153
Cdd:cd17353 293 MFLLPFIgSVAVLFVLGVALIGFCYG----GGFALF----PALTADFFGTKNAGTNYGLlytakGVGGLIGPIIAayvly 364
|
170 180
....*....|....*....|..
gi 488423263 154 ELSFNYIFIANLLMYVLFAIVA 175
Cdd:cd17353 365 TGGYNAAFIIAAALSLVALALA 386
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
275-378 |
3.15e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 275 MIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIGGIL 354
Cdd:cd17391 273 LLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAI 352
|
90 100
....*....|....*....|....
gi 488423263 355 VDAFNMSTMFIGMIVLLSIALCFL 378
Cdd:cd17391 353 AAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
272-381 |
4.05e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.08 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 272 KKQMIVGIIIFMVSFLVTSFAEQFSVFLIGMIILTFGEMFVWPAVPTIANFLAPDGKQGQYQGFVNSASTVGKAFGPLIG 351
Cdd:cd17502 60 KWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIG 139
|
90 100 110
....*....|....*....|....*....|....*...
gi 488423263 352 GILVDAFNMSTMF-----IGMI---VLLSIALCFLAVF 381
Cdd:cd17502 140 GAFTDHLSWRWCFyinlpIGGLalaLLRTILLSSIFGF 177
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
39-176 |
5.47e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.34 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 39 SLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCLVSTTMLNFFHGWPWyavWLVMLGFGGGMIVPA---- 114
Cdd:cd17365 204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLV---LLYVLVFLAGACVNGaqvg 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488423263 115 IYAMAGAVWPNGGRQTFNAIYLA-QNIGVALGAALGGFV--AELSFNYIFIAnllmyvlFAIVAV 176
Cdd:cd17365 281 LYALAARFYPTEVRATGVGWALGvGRLGAILGPLLGGLLlaAGLGPESVFLA-------LAIPAA 338
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
4-153 |
8.26e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 37.89 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488423263 4 PKSVWmLVIGMALNITGSSFLWPLNTI-YMKEELDKSLTIAGIVLMINSFGMVVGNLLGGSLFDKLGGYRTILTGTAVCL 82
Cdd:cd17369 227 WRALL-LAIGLRLAENVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAA 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488423263 83 VSttMLNFFHGWPWYAVWLVMLGF--GGGMIVPAIYAMAGAVWPN--GGRQTFNAIYLAQNIGVALGAALGGFVA 153
Cdd:cd17369 306 LF--AFPFFWLLDTGSTWLIVLAAvvVLGVLHGMMYGPQAAFLAElfPTRVRYTGASLGYQLGAILGGGFAPLIA 378
|
|
| |
