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Conserved domains on  [gi|489057116|ref|WP_002967238|]
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MULTISPECIES: EamA family transporter [Brucella]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 8-118 5.07e-12

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member PRK02971:

Pssm-ID: 474045  Cd Length: 129  Bit Score: 58.85  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057116   8 LFTVMTNAAAQLMLKYGMITLGPISFSADTLiqRIFQIVFNPW--VFAGLFTFVISMASHLYVLSKVDLSFAYPFLSLAY 85
Cdd:PRK02971   8 LASVLLASVAQLSLKWGMSRLPLLSHAWDFI--AALLAFGLALraVLLGLAGYALSMLCWLKALRYLPLSRAYPLLSLSY 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489057116  86 VAVALCAWLL--FKEELGAYKIAGIAFICIGTILI 118
Cdd:PRK02971  86 ALVYLAAMLLpwFNETFSLKKTLGVACIMLGVWLI 120
 
Name Accession Description Interval E-value
PRK02971 PRK02971
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
 8-118 5.07e-12

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional


Pssm-ID: 235094  Cd Length: 129  Bit Score: 58.85  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057116   8 LFTVMTNAAAQLMLKYGMITLGPISFSADTLiqRIFQIVFNPW--VFAGLFTFVISMASHLYVLSKVDLSFAYPFLSLAY 85
Cdd:PRK02971   8 LASVLLASVAQLSLKWGMSRLPLLSHAWDFI--AALLAFGLALraVLLGLAGYALSMLCWLKALRYLPLSRAYPLLSLSY 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489057116  86 VAVALCAWLL--FKEELGAYKIAGIAFICIGTILI 118
Cdd:PRK02971  86 ALVYLAAMLLpwFNETFSLKKTLGVACIMLGVWLI 120
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
50-123 1.90e-05

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 40.85  E-value: 1.90e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489057116  50 WVFAGLFTFVISMASHLYVLSKVDLSFAYPFLS-LAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILIAQSGK 123
Cdd:COG2076   30 PSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTgIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGLKLFSG 104
TMEM234 pfam10639
Putative transmembrane family 234; TMEM234 is a family of putative inner membrane proteins. ...
 67-118 1.76e-03

Putative transmembrane family 234; TMEM234 is a family of putative inner membrane proteins. Many bacterial members are annotated as putative L-Ara4N-phosphoundecaprenol flippase subunit ArnE, and as inner membrane proteins. They may be transporters of the multi-drug-resistant superfamily.


Pssm-ID: 371174  Cd Length: 113  Bit Score: 35.72  E-value: 1.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489057116   67 YVLSKVDLSFAYPFL-SLAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILI 118
Cdd:pfam10639  60 YTLGSTDLSLAVPIAnSLSFVFTVLTGWLLGEKVLGKKTYLGMGLVVAGTALC 112
 
Name Accession Description Interval E-value
PRK02971 PRK02971
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
 8-118 5.07e-12

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional


Pssm-ID: 235094  Cd Length: 129  Bit Score: 58.85  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057116   8 LFTVMTNAAAQLMLKYGMITLGPISFSADTLiqRIFQIVFNPW--VFAGLFTFVISMASHLYVLSKVDLSFAYPFLSLAY 85
Cdd:PRK02971   8 LASVLLASVAQLSLKWGMSRLPLLSHAWDFI--AALLAFGLALraVLLGLAGYALSMLCWLKALRYLPLSRAYPLLSLSY 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489057116  86 VAVALCAWLL--FKEELGAYKIAGIAFICIGTILI 118
Cdd:PRK02971  86 ALVYLAAMLLpwFNETFSLKKTLGVACIMLGVWLI 120
PRK15051 PRK15051
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional
 50-121 7.17e-06

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional


Pssm-ID: 185011  Cd Length: 111  Bit Score: 42.11  E-value: 7.17e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489057116  50 WVFAGLFTFVISMASHLYVLSKVDLSFAYPFLSLAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILIAQS 121
Cdd:PRK15051  39 WLGLALACLGLAMVLWLLVLQNVPVGIAYPMLSLNFVWVTLAAVKLWHEPVSPRHWCGVAFIIGGIVILGST 110
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
50-123 1.90e-05

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 40.85  E-value: 1.90e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489057116  50 WVFAGLFTFVISMASHLYVLSKVDLSFAYPFLS-LAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILIAQSGK 123
Cdd:COG2076   30 PSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTgIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGLKLFSG 104
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
1-119 6.94e-05

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 40.17  E-value: 6.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057116   1 MKYIPFILFTVMTNAAAqlmlkygMITLGPISFSADTLiQRIFQIVFNPWVF---AGLFTFvISMASHLYVLSKVDLSFA 77
Cdd:COG2510   24 LKGIDPNLATFIRTLVA-------LIFLLLILLVTGKL-GELPELSPKSWLFlllSGLATG-LSWLFYFRALKLGPASIV 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489057116  78 YPFLSLAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILIA 119
Cdd:COG2510   95 APIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLS 136
TMEM234 pfam10639
Putative transmembrane family 234; TMEM234 is a family of putative inner membrane proteins. ...
 67-118 1.76e-03

Putative transmembrane family 234; TMEM234 is a family of putative inner membrane proteins. Many bacterial members are annotated as putative L-Ara4N-phosphoundecaprenol flippase subunit ArnE, and as inner membrane proteins. They may be transporters of the multi-drug-resistant superfamily.


Pssm-ID: 371174  Cd Length: 113  Bit Score: 35.72  E-value: 1.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489057116   67 YVLSKVDLSFAYPFL-SLAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILI 118
Cdd:pfam10639  60 YTLGSTDLSLAVPIAnSLSFVFTVLTGWLLGEKVLGKKTYLGMGLVVAGTALC 112
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 51-118 4.38e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 34.86  E-value: 4.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489057116   51 VFAGLFTFVISMASHLYVLSKVDLSFAYPFLSLAYVAVALCAWLLFKEELGAYKIAGIAFICIGTILI 118
Cdd:pfam00892  67 LYLGVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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