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Conserved domains on  [gi|489505129|ref|WP_003410010|]
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MULTISPECIES: type II toxin-antitoxin system toxin endoribonuclease MazF6 [Mycobacterium]

Protein Classification

type II toxin-antitoxin system PemK/MazF family toxin( domain architecture ID 10006385)

type II toxin-antitoxin (TA) system PemK/MazF family toxin similar to Staphylococcus aureus MazF, a ribosome-independent sequence-specific endoribonuclease that cleaves at 5'-UACAU-3' sequences of RNA and is the toxin component of the MazF-MazE TA module

EC:  3.1.-.-
Gene Ontology:  GO:0003677|GO:0004521|GO:0003723|GO:0016075|GO:0006402
PubMed:  23454553|28279904
SCOP:  4002619

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 2-114 1.56e-34

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


:

Pssm-ID: 441908  Cd Length: 111  Bit Score: 114.89  E-value: 1.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505129   2 VISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNAsRLATVIAAVITSNTALAAmPGNVFLPATTTRLPRDSVVNVTAI 81
Cdd:COG2337    1 TPKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNR-YSPTVIVAPITSNIRKGY-PFRVLLPPGENGLKKDSVVLVDQI 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489505129  82 VTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL 114
Cdd:COG2337   79 RTVDKSRLGKKIGRLSEELLEEVLAALKLLLGL 111
 
Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 2-114 1.56e-34

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441908  Cd Length: 111  Bit Score: 114.89  E-value: 1.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505129   2 VISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNAsRLATVIAAVITSNTALAAmPGNVFLPATTTRLPRDSVVNVTAI 81
Cdd:COG2337    1 TPKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNR-YSPTVIVAPITSNIRKGY-PFRVLLPPGENGLKKDSVVLVDQI 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489505129  82 VTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL 114
Cdd:COG2337   79 RTVDKSRLGKKIGRLSEELLEEVLAALKLLLGL 111
PemK_toxin pfam02452
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 5-111 1.05e-28

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


Pssm-ID: 460561  Cd Length: 108  Bit Score: 100.01  E-value: 1.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505129    5 RAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNT-ALAAMPGNVFLPaTTTRLPRDSVVNVTAIVT 83
Cdd:pfam02452   2 RGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNELSTPTVIVAPITSKLkGKAKYPFRVELE-PSLGTNGLSVVLLDQIRT 80

                          90       100
                  ....*....|....*....|....*...
gi 489505129   84 LNKTDLTDRVGEVPASLMHEVDRGLRRV 111
Cdd:pfam02452  81 VDKARLGKKIGRLSDEVMAEVLAALALV 108
 
Name Accession Description Interval E-value
MazF COG2337
mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense ...
 2-114 1.56e-34

mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 441908  Cd Length: 111  Bit Score: 114.89  E-value: 1.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505129   2 VISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNAsRLATVIAAVITSNTALAAmPGNVFLPATTTRLPRDSVVNVTAI 81
Cdd:COG2337    1 TPKRGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNR-YSPTVIVAPITSNIRKGY-PFRVLLPPGENGLKKDSVVLVDQI 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489505129  82 VTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL 114
Cdd:COG2337   79 RTVDKSRLGKKIGRLSEELLEEVLAALKLLLGL 111
PemK_toxin pfam02452
PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. ...
 5-111 1.05e-28

PemK-like, MazF-like toxin of type II toxin-antitoxin system; PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.


Pssm-ID: 460561  Cd Length: 108  Bit Score: 100.01  E-value: 1.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489505129    5 RAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNT-ALAAMPGNVFLPaTTTRLPRDSVVNVTAIVT 83
Cdd:pfam02452   2 RGDIVLVDLDPTVGSEQGKRRPALVVSNDAFNELSTPTVIVAPITSKLkGKAKYPFRVELE-PSLGTNGLSVVLLDQIRT 80

                          90       100
                  ....*....|....*....|....*...
gi 489505129   84 LNKTDLTDRVGEVPASLMHEVDRGLRRV 111
Cdd:pfam02452  81 VDKARLGKKIGRLSDEVMAEVLAALALV 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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