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Conserved domains on  [gi|489521565|ref|WP_003426355|]
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phosphoribosylaminoimidazolesuccinocarboxamide synthase [Clostridioides difficile]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-200 1.80e-48

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


:

Pssm-ID: 439922  Cd Length: 245  Bit Score: 159.09  E-value: 1.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   1 MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEE 80
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDP-------IPGKGEVLNQISAFWFELLEDIGIPTHFIET-LSG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  81 ATMEVLPAKVFGngLEVICRYRAVGSFLRRYGSCV------EEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQA 153
Cdd:COG0152   76 REMLVKKLEMIP--VEVVVRNYAAGSLWKRYQAGIalplglEEGTKLPEpIFEPSTKADEGHDPNISEEHIVALGLATEE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489521565 154 QFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGF-YNDEVILIDEI 200
Cdd:COG0152  154 EAEELRELALKINERLSELAAERGIILVDTKLEFGRdADGEIVLADEI 201
 
Name Accession Description Interval E-value
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-200 1.80e-48

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 159.09  E-value: 1.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   1 MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEE 80
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDP-------IPGKGEVLNQISAFWFELLEDIGIPTHFIET-LSG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  81 ATMEVLPAKVFGngLEVICRYRAVGSFLRRYGSCV------EEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQA 153
Cdd:COG0152   76 REMLVKKLEMIP--VEVVVRNYAAGSLWKRYQAGIalplglEEGTKLPEpIFEPSTKADEGHDPNISEEHIVALGLATEE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489521565 154 QFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGF-YNDEVILIDEI 200
Cdd:COG0152  154 EAEELRELALKINERLSELAAERGIILVDTKLEFGRdADGEIVLADEI 201
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 3-207 1.97e-47

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 156.07  E-value: 1.97e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   3 KVYQGKTKDVFELDNGN-YLLKFKDDVTGKDGVfdpgensVGLSIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEEA 81
Cdd:cd01415    1 LLYEGKAKIVYATDDPDvLIVEFKDDATAFNGK-------KKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEK-LSDR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  82 TMEVLPAKVFGngLEVICRYRAVGSFLRRYGscVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKS 160
Cdd:cd01415   73 EQLVKKVEIIP--LEVVVRNIAAGSLVKRLG--IEEGTVLDPpIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKE 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489521565 161 MTQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEIASGNMRV 207
Cdd:cd01415  149 LALKINEVLSEFFAEIGIILVDFKLEFGRDKDgEIVLADEISPDTCRL 196
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-206 3.66e-46

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 152.95  E-value: 3.66e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   1 MKKVYQGKTKDVFELDNGNYLL-KFKDDVTGKDGVfdpgensVGLSIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLE 79
Cdd:PRK09362   4 KELLYEGKAKIVYSTDDPDLLIvEFKDDATAFNGE-------KKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEK-LS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  80 EATMEVLPAKVFGngLEVICRYRAVGSFLRRYGscVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSM 158
Cdd:PRK09362  76 DREQLVKKVEIIP--LEVVVRNVAAGSLVKRLG--IEEGTVLPPpIVEFYYKNDALGDPMINEDHILALGWATPEELAEI 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489521565 159 KSMTQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEIASGNMR 206
Cdd:PRK09362 152 KELALKINDVLKGLFAGAGIRLVDFKLEFGRDKDgEIVLADEISPDTCR 200
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 3-200 7.91e-46

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 151.75  E-value: 7.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565    3 KVYQGKTKDVFELDNGNYLL-KFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEEA 81
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLvVAKDRISAFDGVKKGT-------IPGKGAVNNQISAFWFELLEIAGIPTHFIKS-LSGR 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   82 TMEVLPAKVFGngLEVICRYRAVGSFLRRY-GscVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMK 159
Cdd:pfam01259  73 EMLVKKVKIIP--LEVVVRNYAAGSLGKRLpG--LKEGTKLPEpIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIR 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 489521565  160 SMTQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEI 200
Cdd:pfam01259 149 ELALKINEILKEYAAERGIILVDTKLEFGLDSDgEIVLADEI 190
 
Name Accession Description Interval E-value
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-200 1.80e-48

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 159.09  E-value: 1.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   1 MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEE 80
Cdd:COG0152    4 LELLYEGKVKDVYATDDDTLLMVFKDRISAFDGVKPDP-------IPGKGEVLNQISAFWFELLEDIGIPTHFIET-LSG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  81 ATMEVLPAKVFGngLEVICRYRAVGSFLRRYGSCV------EEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQA 153
Cdd:COG0152   76 REMLVKKLEMIP--VEVVVRNYAAGSLWKRYQAGIalplglEEGTKLPEpIFEPSTKADEGHDPNISEEHIVALGLATEE 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489521565 154 QFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGF-YNDEVILIDEI 200
Cdd:COG0152  154 EAEELRELALKINERLSELAAERGIILVDTKLEFGRdADGEIVLADEI 201
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 3-207 1.97e-47

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 156.07  E-value: 1.97e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   3 KVYQGKTKDVFELDNGN-YLLKFKDDVTGKDGVfdpgensVGLSIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEEA 81
Cdd:cd01415    1 LLYEGKAKIVYATDDPDvLIVEFKDDATAFNGK-------KKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEK-LSDR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  82 TMEVLPAKVFGngLEVICRYRAVGSFLRRYGscVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKS 160
Cdd:cd01415   73 EQLVKKVEIIP--LEVVVRNIAAGSLVKRLG--IEEGTVLDPpIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKE 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489521565 161 MTQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEIASGNMRV 207
Cdd:cd01415  149 LALKINEVLSEFFAEIGIILVDFKLEFGRDKDgEIVLADEISPDTCRL 196
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-206 3.66e-46

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 152.95  E-value: 3.66e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   1 MKKVYQGKTKDVFELDNGNYLL-KFKDDVTGKDGVfdpgensVGLSIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLE 79
Cdd:PRK09362   4 KELLYEGKAKIVYSTDDPDLLIvEFKDDATAFNGE-------KKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEK-LS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  80 EATMEVLPAKVFGngLEVICRYRAVGSFLRRYGscVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSM 158
Cdd:PRK09362  76 DREQLVKKVEIIP--LEVVVRNVAAGSLVKRLG--IEEGTVLPPpIVEFYYKNDALGDPMINEDHILALGWATPEELAEI 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489521565 159 KSMTQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEIASGNMR 206
Cdd:PRK09362 152 KELALKINDVLKGLFAGAGIRLVDFKLEFGRDKDgEIVLADEISPDTCR 200
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 3-200 7.91e-46

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 151.75  E-value: 7.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565    3 KVYQGKTKDVFELDNGNYLL-KFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEEA 81
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLvVAKDRISAFDGVKKGT-------IPGKGAVNNQISAFWFELLEIAGIPTHFIKS-LSGR 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   82 TMEVLPAKVFGngLEVICRYRAVGSFLRRY-GscVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMK 159
Cdd:pfam01259  73 EMLVKKVKIIP--LEVVVRNYAAGSLGKRLpG--LKEGTKLPEpIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIR 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 489521565  160 SMTQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEI 200
Cdd:pfam01259 149 ELALKINEILKEYAAERGIILVDTKLEFGLDSDgEIVLADEI 190
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 3-211 1.76e-39

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 135.67  E-value: 1.76e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   3 KVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFdpgENSvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSAnLEEAT 82
Cdd:cd00476    1 TLYRGKTKIVYETKDGVLLLEFKDDISAGDGAR---RNF----LDEKGDITAKLTLFIFKYLSEAGIPTHFVER-LGPRT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  83 MEVLPAKVFGngLEVICRYRAVGSFLRRYGScVEEGAKLDC-YVEATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKSM 161
Cdd:cd00476   73 LLVDKLK*IP--LEVVVRNRATGSFVKRYGG-FKEGREFPPpLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KEL 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489521565 162 TQKISNIVRDTIAEKGLELYDIKFEFGFYND-EVILIDEIASGNMRVYKDG 211
Cdd:cd00476  150 AVKINTVLKKLFSPAGLELWDFKLEFGLDEEgEIVLGDEISPDSSRLWRKG 200
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 2-211 2.45e-29

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 110.07  E-value: 2.45e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   2 KKVYQGKTKDVFELDN--GNYLLKFKDDVTGKDGVFDpGEnsvglsIDGIGRANLETSVKFFEILNNAGIKTHYVSANLE 79
Cdd:cd01416    5 KKLIEGKTKIVYELPDqpGLVLIQSKDRITAGDGARK-DE------IEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  80 EATM----EVLPakvfgngLEVICRYRAVGSFLRRYGScVEEGAKLD-CYVEATLKDDDRCDPLITSEGLEALNIM---- 150
Cdd:cd01416   78 TAFIarkcEMIP-------IEWVCRRIATGSFLKRNPG-VKEGYRFSpPKLEFFYKDDANHDPQWSEEQLLEAKLNcggl 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489521565 151 --TQAQFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGFYND--EVILIDEIASGNMRVYKDG 211
Cdd:cd01416  150 kiGKKEVDIMTKSTIAIFEILEKAWATQDCTLVDMKIEFGVDVTtgEILLADVIDNDSWRLWPSG 214
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 3-200 4.32e-24

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 96.46  E-value: 4.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   3 KVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNnAGIKTHYVSANLEEAT 82
Cdd:cd01414    1 LIYSGKVRDVYDLGDGRLLFVATDRISAFDVILPPD-------IPGKGEVLTQISAFWFELTE-DIIPNHLISTDVEDLP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  83 MEVLPAKVFGNG----------LEVICRYRAVGSFLRRY--GSCV---------EEGAKLD-CYVEATLKDDDRCDPLIT 140
Cdd:cd01414   73 EIKEPEDPDGRSmvvkkakpipIECIVRGYLTGSGWKEYqkGGTVcgiklpeglREAQKLPePIFTPSTKAEEGHDENIS 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489521565 141 SEglEALNIMTQAQFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGFY-NDEVILIDEI 200
Cdd:cd01414  153 FE--EAVEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDeNGEIILIDEV 211
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 7-198 3.18e-15

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 73.18  E-value: 3.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   7 GKTKDVF------ELDNGNYLLKFKDDVTgkdgVFDPGEnsVGLSIDGIGRANLETSVKFFEILNNAGIKTHYVS----- 75
Cdd:PRK13959   2 GSVKDFYvdeeptETDLGRGRFVFSDRYS----VFDWGI--MPDEIPDKGASLCTMGAYNFELLEEEGIKTHYIGvvedg 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  76 -----ANLEEAT--MEV----LPAKVFGNG------------------LEVICRYR-AVGSFLRR--------------- 110
Cdd:PRK13959  76 evvrlAEASEPPneMAVkltqVPDLPFEGGsydydayheaagenylipLEVIFRNYvPVGSSLRDrikegkikpedlgld 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565 111 YGSCVEEGAKL-DCYVEATLK--DDDRcdpLITSEglEALNI--MTQAQFDSMKSMTQKISNIVRDTIAEKGLELYDIKF 185
Cdd:PRK13959 156 ADEWPEEGVKLpEPIVEFSTKyeEQDR---YLSRK--EADEIagLSRAEIEELEELALKVDEIITEEAEKRGLIHEDGKI 230

                        250
                 ....*....|....
gi 489521565 186 EFGFYND-EVILID 198
Cdd:PRK13959 231 EFALYEErEIRVVD 244
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 128-200 5.56e-06

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 46.35  E-value: 5.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489521565 128 TLKDDDRCDPlITSEGLEALNIMTQAQFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGFYNDEVI-LIDEI 200
Cdd:PLN02544 206 TTKAADHDVP-ISPEEIVEEGLMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDADGTIlLIDEV 278
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 127-200 1.35e-05

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 44.88  E-value: 1.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489521565 127 ATLKDDDRCDPLITSEGLEALNIMTQAQFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGFY-NDEVILIDEI 200
Cdd:PRK12607 143 TTKAEEGGHDEPISPEEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDaDGRIVLIDEI 217
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 1-200 1.93e-04

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 41.34  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565   1 MKKVYQGKTKDVFELDNGNYLLKFKDDVTGKDGVFDPGensvglsIDGIGRANLETSVKFFEILNNAgIKTHYVSANLEE 80
Cdd:PRK13961  12 LPLLGRGKVRDIYAVDDDRLLMVATDRISAFDVILPEP-------IPDKGRVLTQMSNFWFDKLAHI-VPNHLTGIDVDD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489521565  81 ATMEVLPAKVFGNGleVICR------YRAV------GSFLRRY---GS-C-------VEEGAKLD--CYVEATLKDDDRC 135
Cdd:PRK13961  84 VVPADEADQVLGRA--VVVKklkplpVECVvrgyltGSGWKDYqatGTvCgiklpagLVEASKLPepIFTPATKAELGDH 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489521565 136 DPLITSEglEALNIMTQAQFDSMKSMTQKISNIVRDTIAEKGLELYDIKFEFGFY-NDEVILIDEI 200
Cdd:PRK13961 162 DENISFE--EVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDeDGTLTLMDEV 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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