|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
1-463 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 606.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 1 MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDGMVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMA 80
Cdd:PRK05326 4 INSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRWSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP 160
Cdd:PRK05326 84 RPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGLNLKERVASTLEIESGSNDP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYMLTLILLTLMNNSGVEL---IAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFYTIFITAIAILSYAFSEYLG 237
Cdd:PRK05326 164 MAVFLTITLIELITGGETGLswgFLLLFLQQFGLGALIGLLGGWLLVQLLNRIALPAEGLYPILVLAGALLIFALTAALG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 238 GNGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVL 317
Cdd:PRK05326 244 GSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVFLSL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 318 AKFKFSNKEKLFISWVGLRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDN--TPVLK 395
Cdd:PRK05326 324 LPFRFNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPeaRPVSR 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489531050 396 TFNDYDGEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGSTIIKTGDILVLSG 463
Cdd:PRK05326 404 VELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLG 471
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
1-465 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 579.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 1 MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDGMVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMA 80
Cdd:COG3263 4 LNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRWSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP 160
Cdd:COG3263 84 RPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKGLNLKERLASTLELESGSNDP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYM--LTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFYTIFITAIAILSYAFSEYLGG 238
Cdd:COG3263 164 MAVFltIALIELITGGGASGWSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLPAEGLYPVLVLALALLAFGATALLGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 239 NGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLA 318
Cdd:COG3263 244 SGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFLSLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 319 KFKFSNKEKLFISWVGLRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDNTPVLKTFN 398
Cdd:COG3263 324 PFRFSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPLTRV 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489531050 399 DYD--GEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGSTIIKTGDILVLSGDR 465
Cdd:COG3263 404 ELEllEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPP 472
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
6-383 |
1.06e-32 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 127.76 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 6 IISGLVLLICITSSKvlyKFGVPILLIFILLGMLFGSDGmVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMAKPVAI 85
Cdd:pfam00999 2 VLLILLALLAPLLAR---RLKLPPIVGLIIAGILLGPSG-LGLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 86 PSILMSSLGVIITAGVTGMFCHMVI-GTSLLEGLLIGAIAASTDAASVFAVLRSQKLnLKGSLASLLEVESGSNDPIAYM 164
Cdd:pfam00999 78 SILLLALLGVLIPFVLIGLLLYLLGlGIPLLEALLFGAILSATSPVVVLAILKELGR-VPERLGTLLLGESVLNDGVAVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 165 LTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSN---FEIEGFYTIFITAIAILSYAFSEYLGGNGY 241
Cdd:pfam00999 157 LLAVLLALAQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITrftDDDRELEVLLVLLLALLAALLAEALGVSGI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 242 LSVYISGIIIGNSRI--PLKKSLVHFFDGIswiMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLAK 319
Cdd:pfam00999 237 LGAFLAGLVLSEYPFanKLSEKLEPFGYGL---FNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489531050 320 FKFSNKEKLFISWVGL-RGAASVVFAIyAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARK 383
Cdd:pfam00999 314 LGLSLREALIIGFGGLqRGAVSLALAA-IGPLLGIIARELYPLLIVVVLFTVLVQGITLKPLLFK 377
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
4-389 |
4.75e-13 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 71.07 E-value: 4.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 4 LMIISGLVLLICITSSKVLYKFGVPILLIfiLLGMLFGSDGMVGiyfdNYELTKQLcsIGLIFI---MFFGGFGTNWNMA 80
Cdd:TIGR00831 1 VEIIELVMLATAVAVTVKFIRLPYPIALI--LAGLLLGLAGLLP----EVPLDREI--VLFLFLpplLFEAAMNTDLREL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKgsLASLLEVESGSNDP 160
Cdd:TIGR00831 73 RENFRPIALIAFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKK--LSILLEGESLLNDG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYMLTLILLTLMNNSGVELIAPMVIKQIAF---GLAIGFILAKLSVYILRHSNFE--IEGFYTIFItaiAILSYAFSEY 235
Cdd:TIGR00831 151 AALVVFAIAVAVALGKGVFDPLNAALDFAVVcvgGIAAGLAVGYLAYRLLRAKIDDplVEIALTILA---PFAGFLLAER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 236 LGGNGYLSVYISGIIIGNS----RIPLKKSLV--HFFDGISWIMQIMLFFMLGL---------LSFPSKLPNVFGIAMAI 300
Cdd:TIGR00831 228 FHFSGVIAVVAAGLILTNYgrdfSMSPTTRLIalDFWSVIVFLVNGIIFILIGVqtpgtifsaWKEILVAPAAVILALFT 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 301 SIFMIVIARPLATFI-VLAKF----------KFSNKEKLFISWVGLRGAASV--VFAIYAVTQGVAIENDIFHIIFFIA- 366
Cdd:TIGR00831 308 NAFVIYPVMTYVRFLwTMKPFsnrflkkkpmEFGTRWKHVVSWAGLRGAIPLalALSFPNQLLSGMAFPARYELVFLAAg 387
|
410 420
....*....|....*....|....*
gi 489531050 367 --LLSVGIQGSLIPTVARKLDLVDD 389
Cdd:TIGR00831 388 viLFSLLVQGISLPIFVKRKFVSEH 412
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
1-463 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 606.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 1 MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDGMVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMA 80
Cdd:PRK05326 4 INSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRWSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP 160
Cdd:PRK05326 84 RPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGLNLKERVASTLEIESGSNDP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYMLTLILLTLMNNSGVEL---IAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFYTIFITAIAILSYAFSEYLG 237
Cdd:PRK05326 164 MAVFLTITLIELITGGETGLswgFLLLFLQQFGLGALIGLLGGWLLVQLLNRIALPAEGLYPILVLAGALLIFALTAALG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 238 GNGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVL 317
Cdd:PRK05326 244 GSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVFLSL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 318 AKFKFSNKEKLFISWVGLRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDN--TPVLK 395
Cdd:PRK05326 324 LPFRFNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPeaRPVSR 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489531050 396 TFNDYDGEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGSTIIKTGDILVLSG 463
Cdd:PRK05326 404 VELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLG 471
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
1-465 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 579.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 1 MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDGMVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMA 80
Cdd:COG3263 4 LNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRWSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKGSLASLLEVESGSNDP 160
Cdd:COG3263 84 RPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKGLNLKERLASTLELESGSNDP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYM--LTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSNFEIEGFYTIFITAIAILSYAFSEYLGG 238
Cdd:COG3263 164 MAVFltIALIELITGGGASGWSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLPAEGLYPVLVLALALLAFGATALLGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 239 NGYLSVYISGIIIGNSRIPLKKSLVHFFDGISWIMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLA 318
Cdd:COG3263 244 SGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFLSLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 319 KFKFSNKEKLFISWVGLRGAASVVFAIYAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDNTPVLKTFN 398
Cdd:COG3263 324 PFRFSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPLTRV 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489531050 399 DYD--GEISSKLIEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGSTIIKTGDILVLSGDR 465
Cdd:COG3263 404 ELEllEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPP 472
|
|
| NhaP |
COG0025 |
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]; |
3-392 |
7.53e-54 |
|
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain] Cd Length: 506 Bit Score: 188.25 E-value: 7.53e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 3 ELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSdgMVGIYFD-NYELTKQLCSIGLIFIMFFGGFGTNWNMAK 81
Cdd:COG0025 2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGP--GLGLELDpELGDLEPLLELFLPPLLFEAALNLDLRELR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 82 PVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRsqKLNLKGSLASLLEVESGSNDPI 161
Cdd:COG0025 80 RNGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILR--RLGVPKRLRTILEGESLLNDAT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 162 AYMLTLILLTLMNNSGVEL--IAPMVIKQIAFGLAIGFILAKLSVYILRHSNfeiEGFYTIFIT-AIAILSYAFSEYLGG 238
Cdd:COG0025 158 ALVLFVLALAAALGGGFSLgeALLDFLLAILGGILVGLLLGWLLGRLLRRLP---DPLLEILLTlALPFLAYLLAEALHG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 239 NGYLSVYISGIIIGNSRIP-----LKKSLVHFFDGISWIMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLAT 313
Cdd:COG0025 235 SGVLAVVVAGLVLGNAGRRslspeTRLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 314 FIVLA--KFKFSNKEKLFISWVGLRGAASVVFAIYA---VTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVD 388
Cdd:COG0025 315 FLSLAlrGSRLSWRERLFLSWGGPRGIVSLALALSLplhGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLRE 394
|
....
gi 489531050 389 DNTP 392
Cdd:COG0025 395 DEPE 398
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
6-383 |
1.06e-32 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 127.76 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 6 IISGLVLLICITSSKvlyKFGVPILLIFILLGMLFGSDGmVGIYFDNYELTKQLCSIGLIFIMFFGGFGTNWNMAKPVAI 85
Cdd:pfam00999 2 VLLILLALLAPLLAR---RLKLPPIVGLIIAGILLGPSG-LGLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 86 PSILMSSLGVIITAGVTGMFCHMVI-GTSLLEGLLIGAIAASTDAASVFAVLRSQKLnLKGSLASLLEVESGSNDPIAYM 164
Cdd:pfam00999 78 SILLLALLGVLIPFVLIGLLLYLLGlGIPLLEALLFGAILSATSPVVVLAILKELGR-VPERLGTLLLGESVLNDGVAVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 165 LTLILLTLMNNSGVELIAPMVIKQIAFGLAIGFILAKLSVYILRHSN---FEIEGFYTIFITAIAILSYAFSEYLGGNGY 241
Cdd:pfam00999 157 LLAVLLALAQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITrftDDDRELEVLLVLLLALLAALLAEALGVSGI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 242 LSVYISGIIIGNSRI--PLKKSLVHFFDGIswiMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIARPLATFIVLAK 319
Cdd:pfam00999 237 LGAFLAGLVLSEYPFanKLSEKLEPFGYGL---FNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489531050 320 FKFSNKEKLFISWVGL-RGAASVVFAIyAVTQGVAIENDIFHIIFFIALLSVGIQGSLIPTVARK 383
Cdd:pfam00999 314 LGLSLREALIIGFGGLqRGAVSLALAA-IGPLLGIIARELYPLLIVVVLFTVLVQGITLKPLLFK 377
|
|
| KefB |
COG0475 |
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ... |
1-369 |
1.80e-16 |
|
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain] Cd Length: 384 Bit Score: 80.96 E-value: 1.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 1 MTELMIISGLVLLICITSSKVLYKFGVPILLIFILLGMLFGSDGMVGIyfDNYELTKQLCSIGLIFIMFFGGFGTNWNMA 80
Cdd:COG0475 2 LASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLI--EDSEALELLAELGVVLLLFLIGLELDLKRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFChMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLnLKGSLASLLEVESGSNDP 160
Cdd:COG0475 80 RKMGRRALGIGLLQVLLPFLLGFLLA-LLLGLSLAAALFLGAALAATSTAIVLKVLKELGL-LKTPLGQLILGVALFDDI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYMLTLILLTLMNNSGVEL-IAPMVIKQIAFGLAIGFILAKLSVYILRH-SNFEIEGFYTIFITAIAILSYAFSEYLGG 238
Cdd:COG0475 158 AAILLLALVPALAGGGSVAGsLLLALLKALLFLALLLLVGRYLLRRLFRLvARTRSRELFLLFALLLVLLAAALAELLGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 239 NGYLSVYISGIIIGNSriPLKKSLVHFFDGISWIMQIMLFFMLGLLSFPSKLPNVFGIAMAISIFMIVIaRPLATFIVLA 318
Cdd:COG0475 238 SAALGAFLAGLVLAES--EYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSALLSNPLLALLLVLAAIVG-KLLGAYLAAR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489531050 319 KFKFSNKEKLFIsWVGL--RGAASVVFAIYAVTQGVaIENDIFHIIFFIALLS 369
Cdd:COG0475 315 LFGLSRREALRI-GLLLapRGEFALVLASLGLSAGL-ISPELFAALVLVVLLT 365
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
4-389 |
4.75e-13 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 71.07 E-value: 4.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 4 LMIISGLVLLICITSSKVLYKFGVPILLIfiLLGMLFGSDGMVGiyfdNYELTKQLcsIGLIFI---MFFGGFGTNWNMA 80
Cdd:TIGR00831 1 VEIIELVMLATAVAVTVKFIRLPYPIALI--LAGLLLGLAGLLP----EVPLDREI--VLFLFLpplLFEAAMNTDLREL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 81 KPVAIPSILMSSLGVIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASVFAVLRSQKLNLKgsLASLLEVESGSNDP 160
Cdd:TIGR00831 73 RENFRPIALIAFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKK--LSILLEGESLLNDG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 161 IAYMLTLILLTLMNNSGVELIAPMVIKQIAF---GLAIGFILAKLSVYILRHSNFE--IEGFYTIFItaiAILSYAFSEY 235
Cdd:TIGR00831 151 AALVVFAIAVAVALGKGVFDPLNAALDFAVVcvgGIAAGLAVGYLAYRLLRAKIDDplVEIALTILA---PFAGFLLAER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 236 LGGNGYLSVYISGIIIGNS----RIPLKKSLV--HFFDGISWIMQIMLFFMLGL---------LSFPSKLPNVFGIAMAI 300
Cdd:TIGR00831 228 FHFSGVIAVVAAGLILTNYgrdfSMSPTTRLIalDFWSVIVFLVNGIIFILIGVqtpgtifsaWKEILVAPAAVILALFT 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 301 SIFMIVIARPLATFI-VLAKF----------KFSNKEKLFISWVGLRGAASV--VFAIYAVTQGVAIENDIFHIIFFIA- 366
Cdd:TIGR00831 308 NAFVIYPVMTYVRFLwTMKPFsnrflkkkpmEFGTRWKHVVSWAGLRGAIPLalALSFPNQLLSGMAFPARYELVFLAAg 387
|
410 420
....*....|....*....|....*
gi 489531050 367 --LLSVGIQGSLIPTVARKLDLVDD 389
Cdd:TIGR00831 388 viLFSLLVQGISLPIFVKRKFVSEH 412
|
|
| TrkA_C |
pfam02080 |
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ... |
408-472 |
8.86e-10 |
|
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.
Pssm-ID: 460440 [Multi-domain] Cd Length: 70 Bit Score: 54.54 E-value: 8.86e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489531050 408 LIEVNVDEGNKWANKSIIDSNIPD--DILIVMIKRKEQVLIPKGSTIIKTGDILVLSG--DRIEELIQL 472
Cdd:pfam02080 1 LVEVTVPENSPLVGKTLKELNLPErfGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGtpDDLAALREL 69
|
|
| b_cpa1 |
TIGR00840 |
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ... |
53-390 |
4.85e-09 |
|
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273294 [Multi-domain] Cd Length: 559 Bit Score: 58.64 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 53 YELTKQLCSIGLIFIMFFGGFGTNWNMAkpvaipsilmsSLGvIITAGVTGMFCHMVIGTSLLEGLLIGAIAASTDAASV 132
Cdd:TIGR00840 82 YFMPQRNFFENLGSILIFAVVGTLINAF-----------VIG-LSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 133 FAVLrsQKLNLKGSLASLLEVESGSNDPIAYMLTLILLTLMNNSGVELIAPMVIKQIAF-------GLAIGFILAKLSVY 205
Cdd:TIGR00840 150 LAVF--EEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASffvvtcgGLLVGVVFGFLVAF 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 206 ILRHSNfEIEGFYTIFITAIAILSYAFSEYLGGNGYLSVYISGIII-----GNSRIPLKKSLVHFFDGISWIMQIMLFFM 280
Cdd:TIGR00840 228 ITRFTH-HIRQIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMkkyveANMSRRSQTTIKYFMKMLSSLSETLIFIF 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 281 LGLlSFPSKLPNVFGIAMAISIFMIVIARPLATFIV------LAKFKFSNKEKLFISWVGLRGAASVVFAIYAVTQGVAI 354
Cdd:TIGR00840 307 LGV-SLVTENHEWNWAFVVATLSFCVIYRVLGVRTLswitneFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPY 385
|
330 340 350
....*....|....*....|....*....|....*.
gi 489531050 355 ENDIFHIIFFIALLSVGIQGSLIPTVARKLDLVDDN 390
Cdd:TIGR00840 386 KFLFVTTTLVVVFFTVIFQGGTIKPLVEVLKVKKGC 421
|
|
| TrkA |
COG0569 |
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ... |
393-460 |
5.09e-08 |
|
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440335 [Multi-domain] Cd Length: 296 Bit Score: 54.30 E-value: 5.09e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489531050 393 VLKTFNDYDGEISskLIEVNVDEGNKWANKSIIDSNIPD--DILIVMIKRKEQVLIPKGSTIIKTGDILV 460
Cdd:COG0569 229 VLDVLELADGDAE--IVEVTVPEGSPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
409-461 |
2.30e-07 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 52.82 E-value: 2.30e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 489531050 409 IEVNVDEGNKWANKSIIDSNIPDDILIVMIKRKEQVLIPKGSTIIKTGDILVL 461
Cdd:PRK09496 381 IEAVAHETSKVVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIV 433
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
401-465 |
9.26e-07 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 50.89 E-value: 9.26e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489531050 401 DGEISskLIEVNVDEGNKWANKSI--IDSNIPD-DILIVMIKRKEQVLIPKGSTIIKTGDILVLSGDR 465
Cdd:PRK09496 149 DGRVQ--LVEVKVYEGSPLVGKPLsdLREHFPDiDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAR 214
|
|
| KhtT |
COG0490 |
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ... |
403-472 |
8.70e-06 |
|
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440256 [Multi-domain] Cd Length: 140 Bit Score: 45.30 E-value: 8.70e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489531050 403 EISSKLIEVNVDEGNKWANKSIIDSNIPD--DILIVMIKRKEQVLI-PKGSTIIKTGDILVLSGDR--IEELIQL 472
Cdd:COG0490 65 VLLLAIEEVKVPPGSPLVGKTLGELNLRQrtGVTVVAIRRGGEVILsPGPDTVLEAGDTLVVVGTReqLERLEEL 139
|
|
| COG3273 |
COG3273 |
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only]; |
392-465 |
3.25e-03 |
|
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
Pssm-ID: 442504 [Multi-domain] Cd Length: 387 Bit Score: 39.65 E-value: 3.25e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489531050 392 PVLKTFNDYDGEIsskLIEVNVDEGNKWANKSIIDSNIPDDI--LIVMIKRKEQ-VLIPKGSTIIKTGDILVLSGDR 465
Cdd:COG3273 302 PVVAEAVRESDER---IVRVTVPPGSPLVGKTLGELKLETETgvRVIAIRRGGGwIYDPDGDTRLRAGDVLIVKGTR 375
|
|
| |
