|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
24-451 |
5.03e-136 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 396.94 E-value: 5.03e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFG---NVPG 180
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGadwLGAE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 181 IWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPaaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktk 260
Cdd:cd17359 161 GWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKP-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 261 wirrLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGS 340
Cdd:cd17359 197 ----ILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGM 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 341 TVAITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPI 420
Cdd:cd17359 273 AISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPI 352
|
410 420 430
....*....|....*....|....*....|.
gi 489661679 421 GLAQIGMFWTFVCFIGTNLISLLFVLIFVPE 451
Cdd:cd17359 353 LLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
25-463 |
3.99e-104 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 317.68 E-value: 3.99e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 25 VALISTMGGLLFGYDTGVINGALPFIS-----------SELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLIT 93
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIDffknfglsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 94 MLAGLFFLATVASSLSPSAGW---LIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAF 170
Cdd:pfam00083 81 IANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 171 LGTTFGNVPgiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRSAAEVPAEIDHLKQNLAEDAKHK 250
Cdd:pfam00083 161 LNKTSNSDG--WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 251 QASVRALK-TKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDsaLIANIANGVTAVAATIVTLQLLKHVPR 329
Cdd:pfam00083 239 KASWKELFsTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS--FLVTIIVGVVNFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 330 RPMLIVGLIGSTVA---ITGVTFAsrLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFC 406
Cdd:pfam00083 317 RPLLLLGAAGMAICfviLGIVALL--GVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAA 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 489661679 407 LWLANFGVGVLFPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLETLHRE 463
Cdd:pfam00083 395 NWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDEL 451
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
24-460 |
1.02e-100 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 310.04 E-value: 1.02e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISSELKLAPGS--------QGWVTSSLTLGAAFGAILVGRLSDRYGRRRLItML 95
Cdd:TIGR00879 28 LLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTSANsdsyssslWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSL-LI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 96 AGLFFLA----TVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAfl 171
Cdd:TIGR00879 107 IALLFVIgailMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGS-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 172 GTTFGNVPGIWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRS----AAEVPAEIDHLKQNLAEDA 247
Cdd:TIGR00879 185 GKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGtsgeDKELLDELELIDIKRSIEK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 248 KHKQASVRALKT--KWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLK 325
Cdd:TIGR00879 265 RSVQPSWGSLFSstRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVD 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 326 HVPRRPMLIVGLIGSTVA--ITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAA 403
Cdd:TIGR00879 345 RFGRRPLLLIGAAGMAIClfVLGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIA 424
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 489661679 404 TFCLWLANFGVGVLFPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLETL 460
Cdd:TIGR00879 425 VAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
28-451 |
1.48e-88 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 274.84 E-value: 1.48e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 28 ISTMGGLLFGYDTGVINGALPFISSELKLA--PGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVA 105
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGlsTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 106 SSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTfgnVPGIWRWM 185
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLS---PPGWWRLM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 186 IVLAVIPAIILGIGTYFVPESprwlmmkgrpaaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktkwirRL 265
Cdd:cd17315 158 FALAAVPALLQLLLMFFLPES---------------------------------------------------------RA 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 266 VLIGIGLGVIQQIAGINVMMYYGTSILQMTGfGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAIT 345
Cdd:cd17315 181 LLVGVGLQLLQQLTGINAVMYYAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLL 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 346 GVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGLAQI 425
Cdd:cd17315 260 LLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTI 339
|
410 420
....*....|....*....|....*.
gi 489661679 426 GMFWTFVCFIGTNLISLLFVLIFVPE 451
Cdd:cd17315 340 GLAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
24-458 |
1.01e-84 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 267.13 E-value: 1.01e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISSE----LKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLF 99
Cdd:cd17358 2 LATFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 100 FLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGttfgnvp 179
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 180 giWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLR-SAAEVPAEIDHLKQNLAEDAK-HKQASVRAL 257
Cdd:cd17358 155 --WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRgKDADISKEAAEIQEELAELEKeAKESSFSDL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 258 KTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSAlIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGL 337
Cdd:cd17358 233 FQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPN-TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 338 IG---STVAITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGV 414
Cdd:cd17358 312 IGmgiGLLALGLYFYLQEHGALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIV 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 489661679 415 GVLFPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17358 392 TKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLE 435
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
28-451 |
2.70e-77 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 245.64 E-value: 2.70e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 28 ISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGW---VTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATV 104
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGWqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 105 ASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAflgtTFGNVPGIWRW 184
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVING----AFSYLPGGWRW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 185 MIVLAVIPAIILGIGTYFVPESPRWlmmkgrpaaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktKWIRR 264
Cdd:cd17360 157 MLGLAAVPAVLQFIGLLFLPESPRW--------------------------------------------------PSTRR 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 265 LVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRD--SALIANIANGVTAVaATIVTLQLLKHVPRRPMLIVGLIGSTV 342
Cdd:cd17360 187 ALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNqnAIWLSLIVAGTNFI-FTIVGMYLIDKFGRRKLLLISLFGVIV 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 343 AItgVTFASRLPagspfrafatIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGL 422
Cdd:cd17360 266 AL--VVLAVWLA----------LVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLT 333
|
410 420
....*....|....*....|....*....
gi 489661679 423 AQIGMFWTFVCFIGTNLISLLFVLIFVPE 451
Cdd:cd17360 334 QAIGPYGTFLLFAGLAVLGLIFIYFCVPE 362
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
29-458 |
8.57e-76 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 242.64 E-value: 8.57e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 29 STMGGLLFGYDTGVINGALPFISSEL-------KLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFL 101
Cdd:cd17362 2 PALGGLLFGYDIGATSGALLSITSPAlsgtdwyNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 102 ATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFlgttFGNVPGI 181
Cdd:cd17362 82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYA----FADVVGG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 182 WRWMIVLAVIPAIILGIGTYFVPESPRWlmmKGRpaaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktkw 261
Cdd:cd17362 158 WRYMYGLAAPPALLLGIGMWFLPPSPRW---QGN---------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 262 IRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGF-GRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGS 340
Cdd:cd17362 189 YRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFsAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGM 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 341 TVAITGV-TFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFP 419
Cdd:cd17362 269 VVSLFLLaAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFL 348
|
410 420 430
....*....|....*....|....*....|....*....
gi 489661679 420 IGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17362 349 PLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLE 387
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
25-460 |
4.87e-71 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 233.05 E-value: 4.87e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 25 VALISTMGGLLFGYDTGVINGALP-----FISSE---LKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLA 96
Cdd:PRK10077 13 ITLVATLGGLLFGYDTAVISGTVEslntvFVAPQnlsESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 97 GLFFLATVASSL---------SPSAGWLIG---ARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLA 164
Cdd:PRK10077 93 VLFFISALGSAWpefgftsigPDNTGYVPEfviYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 165 FVLNAFL----GTTFGNVPGiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRSAAEVPAEIDHLK 240
Cdd:PRK10077 173 YFVNYFIarsgDASWLNTDG-WRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 241 QNLaedaKHKQASVRALKTKWIrRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVT 320
Cdd:PRK10077 252 HSL----DHGRKTGGKLLMFGV-GVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTVLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 321 LQLLKHVPRRPMLIVGLIGSTVAITGVTFAsrlpAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGM 400
Cdd:PRK10077 327 IMTVDKFGRKPLQIIGALGMAIGMFSLGTA----FYTQAPGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKAL 402
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489661679 401 GAATFCLWLANFGVGVLFPIGLAQI--------GMFWTFVCFIGtnLISLLFVLIFVPETAGRSLETL 460
Cdd:PRK10077 403 AIAVAAQWIANYFVSWTFPMMDKNSwlvahfhnGFSYWIYGCMG--VLAALFMWKFVPETKGKTLEEM 468
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
24-458 |
1.26e-70 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 229.44 E-value: 1.26e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGAL---------PFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITM 94
Cdd:cd17356 1 LLCAFVSLGGFLFGYDTGSISGILnmksfqkyfADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 95 LAGLFFLATVASSLS-PSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGT 173
Cdd:cd17356 81 GCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 174 TFGNVPgiWRWMIVLAVIPAIILGIGTYFVPESPRWLmmkgrpaaarsslevlrsaaevpaeidhlkqnlaedakhkqas 253
Cdd:cd17356 161 LDGSAQ--WRIPLGLQIVWGLLLLIGMFFLPESPRWL------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 254 vralktkwiRRLvLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPML 333
Cdd:cd17356 196 ---------YRT-ILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 334 IVGLIGS-----TVAITGVTFASRLPAGSPFRAFATIGMMM---LFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATF 405
Cdd:cd17356 266 LIGAAGMsiclfIYAAVGVRYLIPNPQSGTSNKSAGNGMIVficLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATA 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 489661679 406 CLWLANFGVGVLFPIGLAQIGmFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17356 346 FNWLWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLE 397
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
26-455 |
2.16e-66 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 219.83 E-value: 2.16e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 26 ALISTMGGLLFGYDTGVINGALPFI------------SSELKLAPGSQGW--VTSSLTLGAAFGAILVGRLSDRYGRRRL 91
Cdd:cd17357 2 VIVAFGGSFQFGYNIGVVNAPQEVFkefindtlvdryGLNLSDSELDLLWslIVSIFFIGGAIGSFISAFLANRFGRKNG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 92 ITMLAGLFFLATV---ASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLN 168
Cdd:cd17357 82 LLISNALLVVSSLlmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 169 afLGTTFGNVPGiWRWMIVLAVIPAIILGIGTYFVPESPRWLMM-KGRPAAARSSLEVLR-SAAEVPAEIDHLKQNLAED 246
Cdd:cd17357 162 --LPSVLGTETL-WPYLLFFPGIPALLQLAALPFFPESPKFLLIsKGDEEEAEKSLKFLRgIEDDVDQELEEIKKESEQM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 247 AKHKQASVR-ALKTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLK 325
Cdd:cd17357 239 GDQKQVSLMqLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 326 HVPRRPMLIVGLIGSTVAITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATF 405
Cdd:cd17357 319 KVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSS 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 489661679 406 CLWLANFGVGVLFPIgLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGR 455
Cdd:cd17357 399 VNWTSNFIVGMAFPP-LQSIGGGFVFIIFAIPCALFLLYLYRYLPETKGR 447
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
30-455 |
4.14e-62 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 208.34 E-value: 4.14e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISS-------ELKLAPGSQGWVT-------SSLTLGAAFGAILVGRLSDRYGRRRLITML 95
Cdd:cd17431 7 VLGSLQFGYNTGVINAPQKVIEEfynktlgDRYGEPISPETLTtlwslsvAIFSVGGMIGSFSVGLFVNRFGRRNSMLYN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 96 AGLFFLATVASSLSPSAG---WLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNafLG 172
Cdd:cd17431 87 NLLAFAGAALMGLSKLAKsyeMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFG--LE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 173 TTFGNvPGIWRWMIVLAVIPAIILGIGTYFVPESPRWLMMK-GRPAAARSSLEVLRSAAEVPAEIDHLKQNLAEDAKHKQ 251
Cdd:cd17431 165 FILGT-EELWPLLLGFTIVPAILQLALLPFCPESPRYLLINrNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMREKK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 252 ASVRAL-KTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGrdSALIANIANGVTAVAATIVTLQLLKHVPRR 330
Cdd:cd17431 244 VTILELfRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQ--QPVYATIGAGVVNTIFTVVSLFLVERAGRR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 331 PMLIVGLIGSTVAITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLA 410
Cdd:cd17431 322 TLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTS 401
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 489661679 411 NFGVGVLFPIgLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGR 455
Cdd:cd17431 402 NFIVGMCFQY-IANLCGPYVFIIFTVFLLTFFIFTYFKVPETKGK 445
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
28-458 |
1.44e-59 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 200.32 E-value: 1.44e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 28 ISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASS 107
Cdd:cd17437 1 LASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 108 LSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPgiWRWMIV 187
Cdd:cd17437 81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLHVG--WRLMLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 188 LAVIPAIILGIGTYFVPESPRWlmmkgRPAaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktkwIRRLVL 267
Cdd:cd17437 159 VGAVPSLFLAIGVLAMPESPRW-----TPA--------------------------------------------VRRMLI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 268 IGIGLGVIQQIAGINVMMYYGTSILQMTGF-GRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAIT- 345
Cdd:cd17437 190 AALGIHFFQQASGIDAVVLYSPRIFKKAGIkSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTa 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 346 ---GVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGL 422
Cdd:cd17437 270 latSLTFIDRNGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMS 349
|
410 420 430
....*....|....*....|....*....|....*.
gi 489661679 423 AQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17437 350 KAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLE 385
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-458 |
2.13e-54 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 186.16 E-value: 2.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:cd17435 1 LSSVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNaflgTTFGNVPGIWR 183
Cdd:cd17435 81 LLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISN----YAFANVSNGWK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 184 WMIVLAVIPAIILGIGTYFVPESPRWLMMKgrpaaarsslevlrsaaevpaeiDHLKQNLaedakhkqasvralktkwir 263
Cdd:cd17435 157 YMFGLVIPLAALQAIAMYFLPPSPRFLVMK-----------------------DNMRARL-------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 264 rlvLIGIGLGVIQQIAGINVMMYYGTSILQMTGF-GRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGliGSTV 342
Cdd:cd17435 194 ---LIGLTLVFFVQITGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIG--SSVM 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 343 AITGVTFASRLPAGSpfrafatigmMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGL 422
Cdd:cd17435 269 AVSLVTMGLWLSLAS----------LLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVT 338
|
410 420 430
....*....|....*....|....*....|....*...
gi 489661679 423 AQIGMFWtfVCFIGT--NLISLLFVLIFVPETAGRSLE 458
Cdd:cd17435 339 ELIGLPW--VCFIYTamSLASLVFVIMFVPETKGCSLE 374
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-458 |
6.84e-51 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 178.15 E-value: 6.84e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISS----ELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRrLITMLAGLF 99
Cdd:cd17433 2 LATFAAVLGPLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRK-LSLMLCSVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 100 FLATVASSLSPSAGW-LIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGttfgnv 178
Cdd:cd17433 81 FIAGFTVITAAQNVWmLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 179 pgiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRsAAEVPAEIDHLKQNLAEDAKHKQASVRALK 258
Cdd:cd17433 155 ---WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLR-GPDQGWEWECIGIEQSFHLEEQSFSLALLK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 259 TKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSalIANIANGVTAVAATIVTLQLLKHVPRRPMLIvgLI 338
Cdd:cd17433 231 QPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS--VASVIVAAIQVLFTAVAALIMDRAGRKVLLV--LS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 339 GSTVAITGVTFAsrlpagspfraFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLF 418
Cdd:cd17433 307 GVVMVFSTAAFG-----------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEF 375
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 489661679 419 PIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17433 376 SSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
28-451 |
2.52e-47 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 167.81 E-value: 2.52e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 28 ISTMGGLLFGYDTGVING-------ALPFISSELKLAPGSQG------------WVTSSLTLGAAFGAILVGRLSDRYGR 88
Cdd:cd17361 1 VAALGGLIFGYDIGISGGvtsmdpfLEKFFPSVYEKKKGASEnnyckyddqllqLFTSSLYLAGLVASLLASYVTRKWGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 89 RRLItMLAGLFFLA-TVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVL 167
Cdd:cd17361 81 KPSM-LIGGVLFLVgAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 168 NAFLGTTFGNVpgiWRWMIVLAVIPAIILGIGTYFVPESPrwlmmkgrpaaarsslevlrSAAEVpaeidhlkqnlaeda 247
Cdd:cd17361 160 NYGTSKIKPNG---WRLSLGLAAVPALILLLGSLFLPETP--------------------NSPQL--------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 248 khkqasvralktkwirrlvLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHV 327
Cdd:cd17361 202 -------------------VIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRF 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 328 PRRPMLIVGLIGSTVA--ITGVTFASRLPAGSPFRAFATIG---MMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGA 402
Cdd:cd17361 263 GRRFLLLEGGVQMLASqvAIGILLAVKFGDGGELPKAYAIAvvvLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSL 342
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 489661679 403 ATFCLWLANFGVGVLFPIGLAQIgMFWTFVCFIGTNLISLLFVLIFVPE 451
Cdd:cd17361 343 TVAVNFLFTFVIAQAFLSMLCAM-KFGIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-458 |
2.21e-45 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 162.28 E-value: 2.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:cd17436 1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFlgttFGNVPGIWR 183
Cdd:cd17436 81 LILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYF----FSNVLTGWR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 184 WMIVLAVIPAIILGIGTYFVPESPrwlmmkgrpaaarsslevlrsaaevpaEIDHLKQNLaedakhkqasvralktkwiR 263
Cdd:cd17436 157 YMFGLAIIPAAIQFASILLLPKKP---------------------------EVLNIKDNM-------------------R 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 264 RLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGF-GRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTV 342
Cdd:cd17436 191 RRTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFqSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 343 AITGVTFasrlpagspfraFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGL 422
Cdd:cd17436 271 SVSGIGL------------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLI 338
|
410 420 430
....*....|....*....|....*....|....*.
gi 489661679 423 AQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17436 339 DVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLE 374
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
25-457 |
2.45e-44 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 161.24 E-value: 2.45e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 25 VALISTMGG-LLFGYDTGVINGALPFI------------SSELKLAPGSQGW--VTSSLTLGAAFGAILVGRLSDRYGRR 89
Cdd:cd17432 1 ATLAAAFGSsFQYGYNLSVVNSPTPYIqnfynetwteryGTPLEESTLTLLWslTVSIFPLGGLFGSLLVGPLVIRLGRK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 90 RLITMLAGLFFLATVASSLSPSAG---WLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFV 166
Cdd:cd17432 81 GTLLLNNIFAIVAAILMGLSKIAKsfeMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 167 LNafLGTTFGNVPGiWRWMIVLAVIPAIILGIGTYFVPESPRWLMM-KGRPAAARSSLEVLRSAAEVPAEIDHLKQNLAE 245
Cdd:cd17432 161 LG--LRELLGNEEG-WPLLLALTGVPALLQLLTLPFFPESPRYLLIeKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 246 DAKHKQASVRAL-KTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLL 324
Cdd:cd17432 238 EKGVGTVSVLELfRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 325 KHVPRRPMLIVGLIGSTVAITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAAT 404
Cdd:cd17432 318 ERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAG 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 489661679 405 FCLWLANFGVGVLFPIGLAQIGMFwTFVCFIGTNLISLLFVLIFVPETAGRSL 457
Cdd:cd17432 398 SLNWLSNFLVGLLFPFIQEGLGAY-CFLVFAVICLLTAIYIFFVLPETKGKTF 449
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-411 |
2.56e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.03 E-value: 2.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 16 ASAKTRLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITML 95
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 96 AGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTF 175
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 176 GnvpgiWRWMIVLAVIPAIILGIGTYF-VPESPRwlmmkgrpaaarsslevlrsaaevpaeidhlkqnlaedaKHKQASV 254
Cdd:COG2814 162 G-----WRWVFLVNAVLALLALLLLLRlLPESRP---------------------------------------AARARLR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 255 RALKTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLI 334
Cdd:COG2814 198 GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489661679 335 VGLIGSTVAITGVTFASrlpagspfrAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLAN 411
Cdd:COG2814 278 IGLLLLALGLLLLALAG---------SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-458 |
1.73e-34 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 133.42 E-value: 1.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFG----YDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRrLITMLAGLF 99
Cdd:cd17434 2 LAVFSAVLGNFSFGyalvYTSPVIPALEQGDDPRLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRK-LSIMFSAVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 100 FLATVASSLSPSAGW-LIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGttfgnv 178
Cdd:cd17434 81 SALGYLLMGSAQGIWmLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLP------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 179 pgiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRSA-AEVPAEIDHLKQNLAEdaKHKQASVRAL 257
Cdd:cd17434 155 ---WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPnTDYMTEFEQIKDNIRK--QSSRLSWAEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 258 KTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGF----GRDSALIanianGVTAVAATIVTLQLLKHVPRRPML 333
Cdd:cd17434 230 KTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVilepKYDAALV-----GAVRLLSVAIAASLMDKAGRKILL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 334 IVGligstvaiTGVTFASRLPAGspfraFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFG 413
Cdd:cd17434 305 FTS--------AFLMFAANLSMG-----LIPLIAAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFV 371
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 489661679 414 VGVLFPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLE 458
Cdd:cd17434 372 LTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-234 |
1.62e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 117.22 E-value: 1.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 16 ASAKTRLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITML 95
Cdd:COG0477 6 AAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 96 AGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTF 175
Cdd:COG0477 86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 489661679 176 GnvpgiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRSAAEVPA 234
Cdd:COG0477 166 G-----WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALL 219
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
64-458 |
5.54e-28 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 116.27 E-value: 5.54e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 64 VTSSLTLGAAFGAILVGRLSDRYGRRR--LITMLAGLFFlaTVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIA 141
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKvlLLSTLVTAVS--GVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 142 PTSHRGRLVTQNElMVVTGQLLAFVLNAFLgttfgnVPGiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARS 221
Cdd:TIGR00898 210 PKKQRAIVGTLIQ-VFFSLGLVLLPLVAYF------IPD-WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALK 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 222 SLEVLRSAAEVPAEIDHLKQNLAEDA--KHKQASVRAL-KTKWIRRLVLIGIGLgviqqIAGINVmMYYGTsILQMTGFG 298
Cdd:TIGR00898 282 ILQRIAKINGKKLPAEVLSLSLEKDLssSKKQYSFLDLfRTPNLRKTTLCLMML-----WFTTAF-SYYGL-VLDLGNLG 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 299 RDSALIANIaNGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFasrLPAGSPF--RAFATIGMMMLFLAFfq 376
Cdd:TIGR00898 355 GNIYLDLFI-SGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLF---VPVDLYFlrTALAVLGKFGITSAF-- 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 377 gaisPMTWLLMSEIFPEQVRGIGMGAatfCLWLANFGvGVLFPI--GLAQIGMFWTFVCFIGTNLISLLFVLiFVPETAG 454
Cdd:TIGR00898 429 ----QMVYLYTAELYPTVVRNLGVGV---CSTMARVG-SIISPFlvYLGEKWLFLPLVLFGGLALLAGILTL-FLPETKG 499
|
....
gi 489661679 455 RSLE 458
Cdd:TIGR00898 500 VPLP 503
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-447 |
9.93e-28 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 113.47 E-value: 9.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 26 ALISTMGGLLFGYDTGVINGALPFISSELK--LAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGiWR 183
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWG-WR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 184 WMIVLAVIPAIILGigtyfvpesprwlmmkgrpaaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktkWIR 263
Cdd:cd17316 160 ILFLIGALPALLAL---------------------------------------------------------------LLR 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 264 RLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVA 343
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 344 ITGVTFASRLPagspfraFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGLA 423
Cdd:cd17316 257 ALPLFYLLSGS-------PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA 329
|
410 420
....*....|....*....|....
gi 489661679 424 QIGMFWTFVCFIGTNLISLLFVLI 447
Cdd:cd17316 330 STGGTGVPALILALLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-453 |
1.26e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 110.34 E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 16 ASAKTRLRLVALISTMGGLLFGY-DTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITM 94
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYlDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 95 LAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTT 174
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 175 FGnvpgiWRWMIVLAVIPAIILGIgtyfvpesprwlmmkgrpaaarsslevlrsaaevpaeidhlkqnlaedakhkqasv 254
Cdd:COG2271 161 FG-----WRAAFLILGLPGLLLAL-------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 255 ralktkwirrLVLIGIGLGVIQQIAGINVMMYYGTSILQMT-GFGRDSALIANIANGVTAVAATIVTLQLLKHVPRR--P 331
Cdd:COG2271 180 ----------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 332 MLIVGLIGSTVAITGVTFASrlpagspfrAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLAN 411
Cdd:COG2271 250 VLAIGLLLAALALLLLALLP---------SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 489661679 412 FGVGVLFPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETA 453
Cdd:COG2271 321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
24-403 |
1.77e-25 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 107.83 E-value: 1.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWR 183
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-----WR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 184 WMIVLA-VIPAIILGIGTYFVPESPRWLMMKGRPAAARsslEVLRSAAEVPAEIDHLKQNLAEDAKHKQASVRALKTKwI 262
Cdd:TIGR00895 172 SLFYVGgIAPLLLLLLLMRFLPESIDFLVSKRPETVRR---IVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQG-K 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 263 RRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTV 342
Cdd:TIGR00895 248 TARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVF 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489661679 343 AITgvtfasrlpAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAA 403
Cdd:TIGR00895 328 AVL---------VGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWA 379
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-452 |
2.28e-25 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 107.39 E-value: 2.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 28 ISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASS 107
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 108 LSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGiWRWMIV 187
Cdd:cd17371 83 FAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIA-WRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 188 LAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSlevlrsaaevpaeidhlkqnlaedakhkqASVRALKTKWIRRLVL 267
Cdd:cd17371 162 LGALPALLVLFIRRFVKEPPQWQAARAARRHFADR-----------------------------PSLRELFSPPLLRTTL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 268 IGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGV 347
Cdd:cd17371 213 LASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLY 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 348 TFASRlpagspfrAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATfclwlaNFG--VGVLFPIGLAQI 425
Cdd:cd17371 293 FFLPL--------SPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCY------NVGriIGALFPFLVGFL 358
|
410 420 430
....*....|....*....|....*....|.
gi 489661679 426 GMFWT----FVCFIGTNLISLLFVLIFVPET 452
Cdd:cd17371 359 ATSGSlgtaIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-449 |
9.04e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.20 E-value: 9.04e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLS 109
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 110 PSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVpgiWRWMIVLA 189
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG---WRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 190 VIPAIILGIGTYFVPESPRWlmmkgrpaaarsslevlrsaaevpaeidhlKQNLAEDAKHKQASVRALKTKWIRRLVLIG 269
Cdd:cd06174 159 AALALLAAILLLLVVPDPPE------------------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 270 IGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLL-KHVPRRPMLIVGLIGSTVAITGVT 348
Cdd:cd06174 209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGLALLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 349 FASRLPAGSPfrafatigmMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFpiGLAQIGMF 428
Cdd:cd06174 289 LAPSLLLLLL---------LLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA--GFLLAATF 357
|
410 420
....*....|....*....|.
gi 489661679 429 WTFVCFIGTNLISLLFVLIFV 449
Cdd:cd06174 358 GLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-412 |
9.94e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.87 E-value: 9.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 32 GGLLFGYDTGVINGALP-FISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSP 110
Cdd:pfam07690 4 AAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 111 SAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAV 190
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-----WRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 191 IPAIILGIGTYFVPESPrwlmmkgrpaaarsslevlrsaaevpaeidhlkQNLAEDAKHKQASVRALKTKWIRRLVLIGI 270
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPP---------------------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 271 GLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFA 350
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489661679 351 srlpagSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANF 412
Cdd:pfam07690 286 ------SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-449 |
8.16e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.71 E-value: 8.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLS 109
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 110 PSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLA 189
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-----YRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 190 VIPAIILGIGTYFVPESPRwlmmKGRPAAARSSLEVLRSAAEVPAeidhlkqnlaedakhkqasvralktkwiRRLVLIG 269
Cdd:cd17325 157 AALALLALVLALLLLPEPR----PPPNKRAVSAARLRSGLRLLLR----------------------------DRRLLAL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 270 IGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTF 349
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 350 AsrlpagspfRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGLAQIGMFW 429
Cdd:cd17325 285 A---------TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
410 420
....*....|....*....|
gi 489661679 430 TFVCFIGTNLISLLFVLIFV 449
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-448 |
9.35e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 90.69 E-value: 9.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLS 109
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 110 PSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRW-MIVL 188
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-----WRAaFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 189 AVIPAIILGIGTYFVPesprwlmmkGRPAAARSSLEVLRSaaevpaeidhlkqnlaedakhkqasvraLKTKWIRRLVLI 268
Cdd:cd17324 160 AVLALLAALLLWRLLP---------SLPPKKPGSLGLLSS----------------------------LLLLLRNPRLRL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 269 GIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLigstvAITGVT 348
Cdd:cd17324 203 AYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALL-----LLAAAL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 349 FAsrLPAGSPFRAFATIGMMMLFLAFFQGAISPMTWLLMSeifPEQVRGIGMGAATFCLWLANFGVGVLFPIGLAQIGmf 428
Cdd:cd17324 278 LL--LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL---APEARGLASSLYLAAYNLGGALGAALGGLVLDHGG-- 350
|
410 420
....*....|....*....|
gi 489661679 429 WTFVCFIGTNLISLLFVLIF 448
Cdd:cd17324 351 WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
27-452 |
4.19e-19 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 88.87 E-value: 4.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 27 LISTMGGLLFGYDTGVINGALPFIS-----SELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFL 101
Cdd:cd17364 2 IIAGMGFFTDAYDLFSISLVTKILGrlyygGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 102 ATVASSLSPSA------GWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGrlvtqnelmvvtgqllafvlnAFLGTTF 175
Cdd:cd17364 82 GTILSALSPGStplgvmGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRG---------------------ALIAAVF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 176 GNvpgiWRWMIVLAVIPAIILgigtYFVPESPrwlMMKGRPAAARSSLEVLRSAAEVPaeidhlkqnlaedakhkqasvr 255
Cdd:cd17364 141 AM----QGFGILAGAIVTLIL----SAIFEHP---LPAGTYHHADLVWRIVLGLGAIP---------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 256 ALKTKWIRRLVLIGIGLGVIQQIA--GINVmmyYGTSILQMTGFGR----DSALIAN-IANGVTAVAATI----VTLQLL 324
Cdd:cd17364 188 ALSVLYFRKHLLGTAGTWFLLDIAfyGQNL---FQSTIISAIGFSKtmnaYQELFNIaVGQLIIALAGTVpgywFTVFLI 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 325 KHVPRRPMLIVGLIGSTVAITGVTFASRLPAGSPFRAFATIGMMMLFLAFFQGAispMTWLLMSEIFPEQVRGIGMGAAT 404
Cdd:cd17364 265 DRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGLTFFFSNFGPNT---TTFIVPAEVFPARVRSTCHGISA 341
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489661679 405 FCLWLANFGVGVLFPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPET 452
Cdd:cd17364 342 ASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-448 |
2.20e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.86 E-value: 2.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 23 RLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLA 102
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 103 TVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiW 182
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-----W 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 183 RWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVLRSaaevpaeidhlkqnlaedakhkqasvralktkwi 262
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRD---------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 263 RRLVLIGIGLGVIqQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTV 342
Cdd:COG2223 205 PRFWLLSLLYFGT-FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 343 AITGVTFASrlpagspfRAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGL 422
Cdd:COG2223 284 GLLLLALAL--------GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
410 420
....*....|....*....|....*..
gi 489661679 423 AQIGMF-WTFVCFIGTNLISLLFVLIF 448
Cdd:COG2223 356 DATGSYtAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-196 |
1.62e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 80.68 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 31 MGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSP 110
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 111 SAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAV 190
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-----WRWIFLINV 157
|
....*.
gi 489661679 191 IPAIIL 196
Cdd:cd17321 158 PIGLVA 163
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
75-453 |
2.26e-16 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 80.80 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 75 GAILVGRLSDRYGRRRL----ITMLAGLFFLATVASSLSPSAGW----LIGARLILGLAVGGVSVLVPSFLAEIAPTSHR 146
Cdd:cd17367 56 GGWLFGRLADRIGRRAAltlsVSLMAAGSLVIAVTPTYATIGIWapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRR 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 147 GRLVTQNELMVVTGQLLA----FVLNAFLGTTFGNVPGiWRwmivlavIPAIILGIGTYFVpesprwlmmkgrpaaarss 222
Cdd:cd17367 136 GFYSSFQYVTLIGGQLLAlgvlLVLQHTLGEDQMAAWG-WR-------IPFLLGGVLAVVV------------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 223 LEVLRSAAEVPAEidhlkQNLAEDAKHKQASVRALKTKWIRRLVLIGIGLGviQQIAGINVMMYYGTSILQMTGFGRDSA 302
Cdd:cd17367 189 LWLRRGLEETESF-----EAIAESNEASAGTLRELRRHPRELLLVVGLTAG--GTLAFYTWTTYLQKFLVNTAGFSKGDA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 303 LIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFASRlPAGSPFRAFATIGMMMLFLAFFQGaISPm 382
Cdd:cd17367 262 TWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALD-HTDSPYTAFALVLVGLVFLSGYTS-INA- 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489661679 383 twLLMSEIFPEQVRGIGMGAAtFCLWLANF-GVGVLFPIGLAQIGMFWTFVCFI-GTNLISLLFVLIFvPETA 453
Cdd:cd17367 339 --VVKAELFPTHVRALGVGLP-YALAVAIFgGTAPYVALWLKSIGHEWVFFWYVaGLIAISLVVYLRM-PETR 407
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-427 |
1.66e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.41 E-value: 1.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 16 ASAKTRLRLVALIS-TMGGLLFGYDTGVINGALPFI-SSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSD----RYGRR 89
Cdd:COG2211 1 TAAKKKLSLKEKLAyGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 90 R-------LITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSH-RGRLVTQNELMVVTGQ 161
Cdd:COG2211 81 RpwiligaIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 162 LLAFVLNAFLGTTFG-NVPGIWRWMIVLAVIPAIILGIGTYFvpesprwlMMKGRPAAARSSLEVLRSAAEVpaeidhlk 240
Cdd:COG2211 161 LLASVLPPPLVAAFGgDAALGYRLTALIFAVLGLLAFLLTFF--------GTKERPVPEEEKVSLKESLKAL-------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 241 qnlaedakhkqasvraLKTKWIRRLVLIGIGLGVIQQIAGInVMMYYGTSILqmtGFGRDSALIANIANGVTAVAATIVT 320
Cdd:COG2211 225 ----------------LKNRPFLLLLLAYLLFFLALALVAA-LLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLW 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 321 LQLLKHVPRRPMLIVGLIGSTVAITGVTFasrLPAGSPFRAFAtigmMMLFLAFFQGAISPMTWLLMSEIFPEQ------ 394
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFF---LGPGNLWLLLV----LAALAGIGLGAILVLPWAMLADVVDYDewktgr 357
|
410 420 430
....*....|....*....|....*....|....
gi 489661679 395 -VRGIGMGAATFCLWLANFGVGVLFPIGLAQIGM 427
Cdd:COG2211 358 rREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-196 |
3.25e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 76.86 E-value: 3.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 34 LLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAG 113
Cdd:cd17365 9 VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 114 WLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPA 193
Cdd:cd17365 89 QLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-----WRSVFLLGGVPP 163
|
...
gi 489661679 194 IIL 196
Cdd:cd17365 164 LIL 166
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
48-210 |
3.68e-15 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 76.78 E-value: 3.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 48 PFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVG 127
Cdd:cd17441 23 PQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 128 GVSVLVpSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGIGTYFVPESP 207
Cdd:cd17441 103 GVPQSV-TLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLG-----WRWLLILSALPLLIFAVLCFWLPESA 176
|
...
gi 489661679 208 RWL 210
Cdd:cd17441 177 RYW 179
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
27-204 |
4.25e-15 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 76.42 E-value: 4.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 27 LISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVAS 106
Cdd:cd17372 2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 107 SLSPSAGWLIGARLILGLAVGGVSVLVpSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMI 186
Cdd:cd17372 82 AFAPNYMWLIILRCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-----WRWLL 155
|
170
....*....|....*...
gi 489661679 187 VLAVIPAIILGIGTYFVP 204
Cdd:cd17372 156 AFSSVPSSLLLVFYRWTP 173
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
27-463 |
4.66e-15 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 77.08 E-value: 4.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 27 LISTMGGLLFGYDTGVINGALPFIS-----SELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFL 101
Cdd:TIGR00887 19 VIAGVGFFTDSYDLFCISLVTKMLGyvyyhGKGPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMII 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 102 ATVASSLSPSA------GWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLA-----FVLNAF 170
Cdd:TIGR00887 99 ATVASGLSPGSspksvmATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGaivalIVLAGF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 171 -------------LGTTFGNVPGIWRWMIVLAVIPAiilGIGTYF---VPESPRWLMMKGRPA--AARSSLEVLRSAAEv 232
Cdd:TIGR00887 179 khsleaaadeascTGSCVPAVDYMWRILIGFGAVPA---LLALYFrltIPETPRYTADVAKDVeqAASDMSAVLQVKIE- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 233 pAEIDHLkQNLAEDAKHKQASVRALKT---KWIRRLVLIGIGLG-VIQQIAginvmmYYGTS-----ILQMTGFGRDSA- 302
Cdd:TIGR00887 255 -AEPDEV-EKASTAVEVPKASWSDFFThffKWRHGKHLLGTAGSwFLLDIA------FYGVNlnqkvILSAIGYSPPAAt 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 303 -----LIANIANGVT--AVAATI----VTLQLLKHVPRRPMLIVGLIgstvaITGVTFASrlpAGSPFRAFATIGMMMLF 371
Cdd:TIGR00887 327 nnayeELYKTAVGNLiiALAGTVpgywVTVFLVDIIGRKPIQLMGFF-----ILTVLFFV---LGFAYNHLSTHGFLAIY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 372 -LAFFQGAISP--MTWLLMSEIFPEQVR----GIGMGAATFCLWLANFGVGVLFPIGLAQIG---------MFWTFVCFi 435
Cdd:TIGR00887 399 vLAQFFANFGPnaTTFIVPGEVFPTRYRstahGISAASGKAGAIIGQFGFLYLAQHGDPTKGyptgiwmghVLEIFALF- 477
|
490 500
....*....|....*....|....*...
gi 489661679 436 gtNLISLLFVLIfVPETAGRSLETLHRE 463
Cdd:TIGR00887 478 --MFLGILFTLL-IPETKGKSLEELSGE 502
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
63-406 |
1.04e-14 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 74.92 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 63 WVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAP 142
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 143 TSHRGRLVTQNELMVVTGQLLAFVLNAFLGTtfgnvpgiWRWMIVLAVIPAIILGIGTYFVPesprwlmmkgrpaaarss 222
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIRD--------WRWLQLAISLPGLLFLLLLWWLP------------------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 223 levlrsaaevpaeidhlkqnlaedakhkqasvralktkwiRRLVLIGIglgviqqIAGINVMMYYGTSiLQMTGFGRDsA 302
Cdd:cd17317 163 ----------------------------------------RRTIIVGL-------IWFVTSLVYYGLS-LNSSNLGGN-L 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 303 LIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFasrLPAGSPFR--AFATIGMMMLFLAFFqgais 380
Cdd:cd17317 194 YLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTAL---LPDDENTLalTLALVGKFAISAAFS----- 265
|
330 340
....*....|....*....|....*.
gi 489661679 381 pMTWLLMSEIFPEQVRGIGMGAATFC 406
Cdd:cd17317 266 -VIYLYTAELYPTVVRNTGVGLCSTV 290
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
75-429 |
1.93e-13 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 71.64 E-value: 1.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 75 GAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPS---AGW-----LIGARLILGLAVGGVSVLVPSFLAEIAPTSHR 146
Cdd:cd17368 56 GAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTyatIGIaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRR 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 147 G-----RLVTQnELMVVTGQLLAFVLNAFLGTtfgNVPGIWRWMIVLAvIPAIILGIGTYFvpesprwlmmkgrpaaaRS 221
Cdd:cd17368 136 GfytswQSASQ-QVAIVAGALVGYLLSLTLTA---EALAEWGWRIPFF-IGLLIIPLGLWL-----------------RR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 222 SLEvlrsaaEVPAEIDHLKQnlaedaKHKQASVRALKTKWirRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDS 301
Cdd:cd17368 194 SLE------ETEAFLERKAR------PTRRELFALLANNR--RIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 302 ALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVtFASRLPAGSPFRAFATIGMMMLFLAFFQGAIsp 381
Cdd:cd17368 260 SFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPV-FAWLTAAPSFGRLLLVLLVLSFFFGMYGGAM-- 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489661679 382 mtWLLMSEIFPEQVRGIGMgAATFCLWLANFGvgvlfpiGLAQIGMFW 429
Cdd:cd17368 337 --VVALVELFPVRVRSTGF-SLVYALAVAIFG-------GFAQFIVTW 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-203 |
2.23e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.06 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGglLFGY-DTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLF 99
Cdd:cd17319 1 RWRIIPLLFLAY--VINYlDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 100 FLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvp 179
Cdd:cd17319 79 SLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG--- 155
|
170 180
....*....|....*....|....
gi 489661679 180 giWRWMIVLAVIPAIILGIGTYFV 203
Cdd:cd17319 156 --WRWAFIIEGLLGLLLAVLWWFY 177
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-234 |
1.19e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.19 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 31 MGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSP 110
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 111 SAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLvtqneLMVVT-----GQLLAFVlnafLGTTFGNVPGIWRWM 185
Cdd:cd17328 86 NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRA-----LGVFYfaiplGSGLGYV----VGGLVAQATGGWRWA 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 489661679 186 IVLAVIPAIILGIGTYFVPESPRWLMMKG---RPAAARSSLEVLRSAAEVPA 234
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPRGAAEGgvmAKSTATSFLADLKALAKNPS 208
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-448 |
1.19e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.11 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 18 AKTRLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAG 97
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 98 LFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQ---NELMVVTGQLLAFVLnaflgtT 174
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLhafFSLGALLGPLLGGLL------I 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 175 FGNVPGIWRWMIVLAVIPAIILGIGTYFVPesprwlmmkgrpaaarsslevlrsaaevpaeIDHLKQNLAEDAKHKQASV 254
Cdd:COG0738 156 LLGLSLSWHLPYLILAVLLLLLALLFLRSK-------------------------------LPEIEEEEEEAAGSAASLK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 255 RALKTKWIrRLVLIGIGLGVIQQIAGINVMMYYGTSILQMtgfgrdSALIANIANGVTAVAATI---VTLQLLKHVPRRP 331
Cdd:COG0738 205 SLLKNPRL-LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL------SEATAALGLSLFWGGMTIgrfLGGFLLKRFGPVR 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 332 MLIVGLIGSTVAITGVTFASrlpagspfrAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQvrgiGMGAATFCLWLAN 411
Cdd:COG0738 278 LLRLSALLAAVGLLLALLAP---------GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR----TAAAVSAVLIMGI 344
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 489661679 412 FGVGVLFPI--GLAQ-IGMFWTFVCFIGTNLISLLFVLIF 448
Cdd:COG0738 345 VGGAIGPPLigFLADaFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-436 |
1.32e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 69.14 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLA 125
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 126 VGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWM-IVLAVIPAIILGIGTYFVP 204
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFG-----WRAIfVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 205 ESPRwlmmkgRPAAARSSLEVLRSAAEVpaeidhlkqnlaedAKHKQAsvralktkwIRRLVLIGIGLGVIQ---QIAGI 281
Cdd:cd17320 176 ETLP------EEKRKPLLSSLLRAYKRV--------------LKNRRF---------LGYALALGLSFAGLFaylAAAPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 282 NVMMYYGTSILQmtgFGrdsalIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFASrlpAGSPFRA 361
Cdd:cd17320 227 IYIEQLGLSPAQ---FG-----LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAA---LLGGLSL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489661679 362 FATIGMMMLFLAFFqGAISPMTWLLMSEIFPeQVRGIG---MGAATFCL-WLANFGVGVLFPIGLAQIGMFWTFVCFIG 436
Cdd:cd17320 296 WPLVAPLFLIFFGF-GLIFPNATSLALEPFP-HVAGTAsalLGFLQFLIgALAGALVGLLPNGTALPMGLLILVLGLLA 372
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
12-226 |
6.79e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 66.91 E-value: 6.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 12 TGHLASAKTRLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRL 91
Cdd:PRK11551 3 TRTSSASSSRLALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 92 ITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFL 171
Cdd:PRK11551 83 LIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLA 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 489661679 172 GttfgnVPGIWRWM-IVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVL 226
Cdd:PRK11551 163 A-----GDAAWRHIfYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRAL 213
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
48-206 |
1.28e-11 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 65.98 E-value: 1.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 48 PFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRR--LITMLAGLFFlaTVASSLSPSAGWLIGARLILGLA 125
Cdd:cd17442 25 PEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKilLLSFVWGAYF--SLLTSFAPSYIWFVFLRCMVGCG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 126 VGGVS---VLVPSFLaeiaPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGIGTYF 202
Cdd:cd17442 103 VSGHSqglIIKTEFL----PTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLG-----WRWLIRFASIPGIILIVVFKF 173
|
....
gi 489661679 203 VPES 206
Cdd:cd17442 174 IPRT 177
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
42-216 |
1.32e-11 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 66.50 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 42 VINGALPFISSELkLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLI 121
Cdd:cd06179 16 LPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 122 LGLAvGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTtfgNVPGIWRWMIVLAVIPAIILGIGTY 201
Cdd:cd06179 95 IGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVE---ANAAGWRWIFYINAIFNALALILLF 170
|
170
....*....|....*
gi 489661679 202 FVPESPRWLMMKGRP 216
Cdd:cd06179 171 FFYHPPPRPQLHGSS 185
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
37-215 |
1.47e-11 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 66.54 E-value: 1.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 37 GYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRR--LITMLAGLFFlaTVASSLSPSAGW 114
Cdd:TIGR01299 180 GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQclLICLSVNGFF--AFFSSFVQGYGF 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 115 LIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQL----LAFVLNAFLGTTFGNVPGI----WRWMI 186
Cdd:TIGR01299 258 FLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIyaaaMAWAIIPHYGWSFQMGSAYqfhsWRVFV 337
|
170 180
....*....|....*....|....*....
gi 489661679 187 VLAVIPAIILGIGTYFVPESPRWLMMKGR 215
Cdd:TIGR01299 338 IVCAFPCVFAIGALTFMPESPRFFLENGK 366
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
37-215 |
1.49e-11 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 66.10 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 37 GYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLI 116
Cdd:cd17438 12 GVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 117 GARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVL----------NAFLGTTFGNVPgiWRWMI 186
Cdd:cd17438 92 FCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMawsiiphygwGFSMGTNYHFHS--WRVFV 169
|
170 180
....*....|....*....|....*....
gi 489661679 187 VLAVIPAIILGIGTYFVPESPRWLMMKGR 215
Cdd:cd17438 170 IICALPCIASIIALKFMPESPRFLLEMGK 198
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
30-204 |
2.99e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 64.90 E-value: 2.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLS 109
Cdd:cd17503 2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 110 PSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLA 189
Cdd:cd17503 82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-----WRWIFYIN 156
|
170
....*....|....*
gi 489661679 190 VIPAIILGIGTYFVP 204
Cdd:cd17503 157 LPIGILALLLAPLLD 171
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-202 |
4.66e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.12 E-value: 4.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 31 MGGLLFGYDTGVINGALPFISSELKLApGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSP 110
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGL-SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 111 SAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLvtQNELMVVTGqlLAFVLNAFLGTTFGNVPGiWRW------ 184
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY--QGYIGAVFG--IASVAGPLIGGAFTDHLS-WRWcfyinl 156
|
170 180
....*....|....*....|.
gi 489661679 185 ---MIVLAVIPAIILGIGTYF 202
Cdd:cd17502 157 pigGLALALLRTILLSSIFGF 177
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
24-448 |
8.12e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 8.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGgllfgydTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:cd17474 6 FATLLAVLG-------VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTfgnvpgIWR 183
Cdd:cd17474 79 LLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI------SWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 184 WMIVLAVIPAIILGIGTYFVPESPRwlmmkgrpaaarsslevlrsaaevpaeidhlKQNLAEDAKHKQASVRALKTKWIr 263
Cdd:cd17474 153 YPFFLLAALIPVAFLAILFLLPEPK-------------------------------EKAKSSSATKLRDLKKALRGRGL- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 264 RLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRdsALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVA 343
Cdd:cd17474 201 LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII--GLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 344 ITGVTFASRLPAGSPFRAFATIGmmmlflaffQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGLA 423
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLFGLG---------LGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
|
410 420
....*....|....*....|....*
gi 489661679 424 QIGMFWTFVCFIGTNLISLLFVLIF 448
Cdd:cd17474 350 IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-198 |
1.07e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.98 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 31 MGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSP 110
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 111 SAGWLIGARLILGLAvGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAV 190
Cdd:cd17504 83 NLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-----WRWIFWTAA 156
|
....*...
gi 489661679 191 IPAIILGI 198
Cdd:cd17504 157 PVAVLLAA 164
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
39-203 |
1.95e-10 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 62.78 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 39 DTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGA 118
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 119 RLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGI 198
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYH-----WRWIFLINVPIGIIVVV 171
|
....*
gi 489661679 199 GTYFV 203
Cdd:TIGR00711 172 VAFFI 176
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
37-215 |
3.36e-10 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 61.85 E-value: 3.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 37 GYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRR--LITMLAGLFFlaTVASSLSPSAGW 114
Cdd:cd17440 12 GVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQslLICMSVNGFF--AFLSSFVQGYGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 115 LIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGI--------WRWMI 186
Cdd:cd17440 90 FLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMgsayqfhsWRVFV 169
|
170 180
....*....|....*....|....*....
gi 489661679 187 VLAVIPAIILGIGTYFVPESPRWLMMKGR 215
Cdd:cd17440 170 IVCALPCVSSVVALTFMPESPRFLLEVGK 198
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-208 |
4.66e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 61.04 E-value: 4.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 25 VALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFF--LA 102
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLaaLA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 103 TVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTqneLMVVTGQLLAFVLNAFLGTTFGNVpGIW 182
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASG---LVNTFGFLGGALGPLLVGYLLDAT-GYQ 337
|
170 180
....*....|....*....|....*.
gi 489661679 183 RWMIVLAVIPAIILGIGTYFVPESPR 208
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
37-215 |
5.03e-10 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 61.35 E-value: 5.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 37 GYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLI 116
Cdd:cd17363 12 GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 117 GARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLN---------AF-LGTTFGNVPgiWRWMI 186
Cdd:cd17363 92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAwaiiphygwGFsMGTAYQFHS--WRVFV 169
|
170 180
....*....|....*....|....*....
gi 489661679 187 VLAVIPAIILGIGTYFVPESPRWLMMKGR 215
Cdd:cd17363 170 IVCALPSVASVVALTFMPESPRFLLEVGK 198
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
32-196 |
1.12e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.88 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 32 GGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPS 111
Cdd:cd17477 4 SVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 112 AGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVvtgqLLAFVLNAFLGTTFGNVPGIWRWMIVLAVI 191
Cdd:cd17477 84 PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVL----GLGFALGPLLLALVGTAGALPFLIAAVLLL 159
|
....*
gi 489661679 192 PAIIL 196
Cdd:cd17477 160 LALVP 164
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
68-401 |
2.07e-09 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 59.08 E-value: 2.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 68 LTLGAAF-----GAILVGRLSDRYGRRR--LITMLagLFFLATVASSLSP---SAGW-----LIGARLILGLAVGGV--- 129
Cdd:cd17369 48 ATFGVGFlarplGGVVFGHFGDRIGRKKtlVLTLL--LMGIATFLIGLLPtyaQIGIlapilLVLLRLLQGLALGGEwgg 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 130 SVLVpsfLAEIAPTSHRGRLVTQNELMVVTGQLLA----FVLNAFLGTTFGNVPGiWRwmivlavIP----AIILGIGTY 201
Cdd:cd17369 126 AVLM---AVEHAPPKRRGFYGSFPQLGAPVGLLLAtgvfLLLSALLSDEAFLSWG-WR-------IPfllsAVLVAVGLY 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 202 F---VPESPRWLMMKGRPAAARSSLevlrsaaevpaeidhlkqnlaedakhkqasVRALKTKWirRLVLIGIGLGVIQQI 278
Cdd:cd17369 195 IrlrLEETPVFRRAKEAGQVVRAPL------------------------------VEVLRRHW--RALLLAIGLRLAENV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 279 A---GINVMMYYGTSILqmtGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGStvAITGVTFASRLPA 355
Cdd:cd17369 243 LfylFTTFALSYATQTL---GVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLA--ALFAFPFFWLLDT 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489661679 356 GSPFrafATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMG 401
Cdd:cd17369 318 GSTW---LIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGAS 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-421 |
2.72e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 2.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLS 109
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 110 PSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAfvlnAFLGTTFGNVPGIWRWMIVLA 189
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALG----PALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 190 VIPAIILGIGtyfvpesprwLMMKGRPAAARSSlevlrsaaevpaeidhlkQNLAEDAKHKQASVRALKTKWIrrLVLIG 269
Cdd:cd17489 158 VLALLALLLV----------FLVKDPPPVAAEE------------------AEAGTRAFRRLVEKKVLPPALI--LFLAS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 270 IGLGVIQQIaginVMMYYGTSILQMTGFgrdsaliANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTF 349
Cdd:cd17489 208 IAYGAISTF----LPLYAAERGISNAGL-------FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 350 AsrlpagspfrafATIGMMMLFLAFF---QGAISPMTWLLMSEIFPEQVR-------------GIGMGAATFCLWLANFG 413
Cdd:cd17489 277 A------------GSPWMLLLAAVLYglgFGLLFPALQALAVDLVPPHRRgaangtffiffdlGIGLGGLLLGLVAELFG 344
|
....*...
gi 489661679 414 VGVLFPIG 421
Cdd:cd17489 345 YRAMFLLA 352
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
62-205 |
3.25e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 55.35 E-value: 3.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 62 GWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIA 141
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489661679 142 PTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGIGTYFVPE 205
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG-----WRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-202 |
5.22e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.01 E-value: 5.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFF 100
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 101 LATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpg 180
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG---- 361
|
170 180
....*....|....*....|..
gi 489661679 181 iWRWMIVLAVIPAIILGIGTYF 202
Cdd:cd06173 362 -LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-412 |
9.62e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.20 E-value: 9.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGllfgydtGVINGALPFISSELKLAPGSQ-GWVTSSLTLGAAFGAILVGRLSDRYGRRRLItmLAGLFF-- 100
Cdd:cd17473 6 LASTLTVMAG-------AAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLL--IAGLLLyg 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 101 LATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGtTFGnvpg 180
Cdd:cd17473 77 IGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIG---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 181 iWRWMIVLAVIPAIILGIGTYFVPESPRwlmmkgrpaaarsslevlrsaaevpaeidhlkqnlaEDAKHKQASVRALKTK 260
Cdd:cd17473 152 -WRAPFLVYLLALPVLILVLLFLPEPAR------------------------------------KSKSAASPGAATAAAL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 261 WIRRLVLIGIglgviqqIAGINVMMYYGTSI---LQMTGFGRDSALIANIANGVTAVAATIVTLQ---LLKHVPRRPMLI 334
Cdd:cd17473 195 PWKRVLPIYF-------LAFLAMLLFYVIPIqlpFLLQERGGGSAALIGLALAIASLAGAIGALLfgrLKRRLGKRRLLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 335 VGLIGSTVAITGVTFASrlpagspfrafaTIGMMMLFLAFFQ---GAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLAN 411
Cdd:cd17473 268 IGFALMALGFLLLALAS------------GLWVVLLGAILAGlgfGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
.
gi 489661679 412 F 412
Cdd:cd17473 336 F 336
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-198 |
1.81e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 4 SKTHNHRFTGHLASAKTRLRLVALISTMGGLLFGYdTGVINGALpFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLS 83
Cdd:cd17473 180 SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFY-VIPIQLPF-LLQERGGGSAALIGLALAIASLAGAIGALLFGRLK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 84 DRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLL 163
Cdd:cd17473 258 RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFL 337
|
170 180 190
....*....|....*....|....*....|....*
gi 489661679 164 AFVLNAFLGTTFGNVPGIWRWMIVLAVIPAIILGI 198
Cdd:cd17473 338 SPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-198 |
2.90e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.30 E-value: 2.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGGLLFGYDtgVINGALP-FISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRR--LITMLAG 97
Cdd:cd17316 176 RRRTLLLILLWFFISFGYY--GLTTFLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKtlVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 98 LFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLV-TQNELMVVTGQLLAFVLNAFLGTTFG 176
Cdd:cd17316 254 GILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVgLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|..
gi 489661679 177 nvPGIWRWMIVLAVIPAIILGI 198
Cdd:cd17316 334 --TGVPALILALLAIVALIVAL 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
4-203 |
3.69e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 3.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 4 SKTHNHRFTGHLASAKTRLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQ-GWVTSSLTLGAAFGAILVGRL 82
Cdd:cd17474 178 EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIiGLLFAGWSVLLALGSLFVGRL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 83 SD-RYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQ 161
Cdd:cd17474 258 LKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQ 337
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 489661679 162 LLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGIGTYFV 203
Cdd:cd17474 338 AVGPLLFGLLLEIFG-----LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-202 |
1.14e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.73 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 27 LISTMGGLLFGYDTGVINGALP-FISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVA 105
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 106 SSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWM 185
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-----FATP 356
|
170
....*....|....*..
gi 489661679 186 IVLAVIPAIILGIGTYF 202
Cdd:cd17325 357 FLAAAALLLLAAVLFLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-199 |
1.42e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.75 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSP--SAGWLIGARLILG 123
Cdd:COG2211 251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAG 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 124 LAVGGVSVLVPSFLAEIAPtSHRGRLVTQNE--------LMVVTGQLLAFVLNAFLGTTFGNVPG-------IWRWMIVL 188
Cdd:COG2211 331 IGLGAILVLPWAMLADVVD-YDEWKTGRRREglyfgiftFAIKLGQALAGALAGLLLALFGYVAGaaqspsaLTGIRLLF 409
|
170
....*....|.
gi 489661679 189 AVIPAIILGIG 199
Cdd:COG2211 410 FLLPAVLLLLA 420
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
46-142 |
4.14e-07 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 52.00 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLA 125
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90
....*....|....*..
gi 489661679 126 VGGVSVLVPSFLAEIAP 142
Cdd:TIGR00710 107 ASAGSVISQALVRDIYP 123
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
46-223 |
5.35e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 51.98 E-value: 5.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPgSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLA 125
Cdd:pfam06609 66 ALPNILQDIGQSE-NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 126 VG--GVSvlvPSFLAEIAP--TSHRGRLVTQNELMVVTGqllafvLNAFLGTTFGnVPGIWRWMIVLAVIPAII--LGIG 199
Cdd:pfam06609 145 AGpaGAS---PLFIGELMSnkTKFLGLLIVSAPTIAMNG------AGPYFGQRLA-IQGNWRWIFYIYIIMSAIavLLII 214
|
170 180
....*....|....*....|....
gi 489661679 200 TYFVPesPRWLMMKGRPAAARSSL 223
Cdd:pfam06609 215 IWYHP--PSFAQLHGKKARKRDEL 236
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
39-140 |
5.54e-07 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 52.04 E-value: 5.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 39 DTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGA 118
Cdd:PRK14995 21 DATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIAT 100
|
90 100
....*....|....*....|..
gi 489661679 119 RLILGLavgGVSVLVPSFLAEI 140
Cdd:PRK14995 101 RALLAI---GAAMIVPATLAGI 119
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
47-427 |
9.07e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 9.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 47 LPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAV 126
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 127 GGVSVLVPSFLAEIAPtSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGIgtyfvpes 206
Cdd:COG2807 121 AVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG-----WRGALAVWALLALLALL-------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 207 PRWLMMKGRPAAARSslevlrsaaevpaeidhlkqnlaedAKHKQASVRALKTkwiRRLVLIGIGLGViqQIAGINVMMY 286
Cdd:COG2807 187 LWLPLLRRRPAAAAA-------------------------APAAASLRSLWRS---PLAWLLTLFFGL--QSLLYYAVVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 287 YGTSILQMTGFGRDSA-LIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLigstvaitgvtfasrlpagspfrAFATI 365
Cdd:COG2807 237 WLPPILRDAGLSAATAgLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG-----------------------LLGLA 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489661679 366 GMMMLFLAffqGAISPMTWLLmseifpeqvrgigmgaatfclwLANFGVGVLFPIGLAQIGM 427
Cdd:COG2807 294 GLLGLLLA---PGSLPWLWAV----------------------LLGLGQGGLFPLALTLIGL 330
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
14-226 |
9.32e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 51.24 E-value: 9.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 14 HLASAKTRLRLVALIstmGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLIT 93
Cdd:PRK03893 13 HLNRAQWKAFSAAWL---GYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 94 MLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGR----LVTQNELmvvtGQLLAFVLNA 169
Cdd:PRK03893 90 ISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKasgfLISGFSI----GAVVAAQVYS 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 489661679 170 FLGTTFGnvpgiWRWMIVLAVIPAIILGIGTYFVPESPRWLMMKGRPAAARSSLEVL 226
Cdd:PRK03893 166 LVVPVWG-----WRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDIL 217
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
43-147 |
1.87e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.89 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 43 INGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRR--LITMLAGLFFLATVASSLSPSAgWLIGARL 120
Cdd:cd17365 190 LNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRvlALFFALGAVSLALLGVSPASLV-LLYVLVF 268
|
90 100
....*....|....*....|....*..
gi 489661679 121 ILGLAVGGVSVLVPSFLAEIAPTSHRG 147
Cdd:cd17365 269 LAGACVNGAQVGLYALAARFYPTEVRA 295
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
46-206 |
1.92e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 49.91 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLA 125
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 126 VGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWR---WMIVLAVIPAIILGIgtYF 202
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS-----WHaifWVLALAAILAAALVF--FF 165
|
....
gi 489661679 203 VPES 206
Cdd:PRK11102 166 IPET 169
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
64-196 |
2.41e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 49.45 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 64 VTSSLTLGAAFGAI---LVGRLSDRYGRRR--LITMLAGLFFLATVASSLSPSAGWLI--GARLILGLAVGGVSVLVPSF 136
Cdd:cd17369 266 VLLAVLIASVVAAItipLFGWLSDRVGRRPvyLAGALLAALFAFPFFWLLDTGSTWLIvlAAVVVLGVLHGMMYGPQAAF 345
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489661679 137 LAEIAPTSHR--GRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGIWrWMIVLAVIPAIIL 196
Cdd:cd17369 346 LAELFPTRVRytGASLGYQLGAILGGGFAPLIATALVAATGSWWPVAL-YLAALAVISLVAA 406
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
62-455 |
2.73e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 49.38 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 62 GWVTSSLTLGAAFGAILVGRLSDRYGRR-RLITMLAGLFFLATVASSLSPSAGWLIGArLILGLA---VGGVSVLVPSFL 137
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkPFLAFFTLLGVLATAALFFVAPGGLWLGL-LLFVLAnigFEGSLVFYNAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 138 AEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFL---GTTFGNVPGIW--RWMIVLAVIPAIILGIGT-YFVPESPrwlm 211
Cdd:COG2270 134 PDIATPEEIGRVSGLGWALGYLGGVLLLLINLALflkPEAFGLPDAGEavRISFLLTALWWLLFALPLfLFLPERP---- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 212 mkgRPAAARSSLEVLRSAAEVPAEIDHLKQNlaedakhkqasvRALKTKWIRRLVLigiglgviqqIAGINVMMYYGTSI 291
Cdd:COG2270 210 ---RPGPAPPRGAVRAGFRELRRTLRELRRY------------RDLLRFLLAYFFY----------RDGVQTVIAFAGIY 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 292 LQMT-GFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFASRLPAgspfrafatIGMMML 370
Cdd:COG2270 265 AAGVlGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALA---------FWILGL 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 371 FLAFFQGAISPMTWLLMSEIFPEQVRGIGMG----AATFCLWLANFGVGVLFPI-GLAQIGMFWTFVCF-IGtnlislLF 444
Cdd:COG2270 336 LIGLVMGGIQALSRSLLARLIPPGREAEFFGlyalSGKAASFLGPLLFGLVTQLtGSQRLGILSLIVFFvIG------LV 409
|
410
....*....|.
gi 489661679 445 VLIFVPETAGR 455
Cdd:COG2270 410 LLLRVKVPRGR 420
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
37-215 |
3.42e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.26 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 37 GYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLI 116
Cdd:cd17439 12 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 117 GARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQL----LAFVLNAFLGTTFGNVPGI----WRWMIVL 188
Cdd:cd17439 92 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIyasaMAWAIIPHYGWSFQMGSAYqfhsWRVFVLV 171
|
170 180
....*....|....*....|....*..
gi 489661679 189 AVIPAIILGIGTYFVPESPRWLMMKGR 215
Cdd:cd17439 172 CAFPSVFAIGALTTMPESPRFFLENGK 198
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-449 |
3.63e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 3.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 49 FISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRliTMLAGLFFLATVASSL--SPSAGWLIGARLILGLAV 126
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKP--VMLAGLLLRALGFALLgfAHSPWLFAIALVLTGFGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 127 GGVSVLVPSFLAEIAPTSHRGRlvtqnelmvvtgqllAFVLNaflgttfgnvpgiwRWMIVLAVipAIILGIGTYFVPES 206
Cdd:cd17329 103 GLFEPASEAMIADVTTPENRTR---------------AFSLL--------------YWAINLGV--AIGPLLGGLLLLYS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 207 PRWLMMKgrpAAARSSLEVLRSAAEVPAEIdhlkqnLAEDAKHKQASVRALKTKWIRRLVLIGIGLGVIQQIAGINVMMY 286
Cdd:cd17329 152 FRLLFLA---AAVLFLLAALVLLFLLPETR------PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 287 YGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFASRLPAGSPFRAFATIG 366
Cdd:cd17329 223 LPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 367 MMMLFlaffqgaisPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGLAQIGMFWTFVCFIGTNLISLLFVL 446
Cdd:cd17329 303 EMLVF---------PAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
...
gi 489661679 447 IFV 449
Cdd:cd17329 374 GLQ 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
258-470 |
4.41e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 4.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 258 KTKWIRRLVLIGIGLGVIQQIAGINVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGL 337
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 338 IGSTVAITGVTFASrlpagspfrAFATIGMMMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVL 417
Cdd:COG2814 83 LLFALGSLLCALAP---------SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 489661679 418 FPIGLAQIGMFWTFVCFIGTNLISLLFVLIFVPETAGRSLETLHREEKARLNH 470
Cdd:COG2814 154 GGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR 206
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-148 |
5.69e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 5.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 22 LRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFL 101
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 489661679 102 ATVA---SSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGR 148
Cdd:pfam07690 278 AALGlllLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGT 327
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-203 |
5.91e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.33 E-value: 5.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGGLLFGydtgVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFF 100
Cdd:COG2807 216 LAWLLTLFFGLQSLLYY----AVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 101 LATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHR-GRLVTqneLMVVTGQLLAFV---LNAFLGTTFG 176
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSG---MAQSVGYLLAALgplLVGALHDATG 368
|
170 180
....*....|....*....|....*..
gi 489661679 177 NvpgiWRWMIVLAVIPAIILGIGTYFV 203
Cdd:COG2807 369 S----WTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-448 |
6.88e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 6.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRL-----ITMLAGLFFLATVASSLSPSAGWLIGARL 120
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 121 ILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNvpgiwRWMIVLAVIPAIILGIGT 200
Cdd:cd06173 101 LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP-----GGAFAINALSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 201 YFVPESPRwlmmkgrpaaarsslevlrsaaevpaeidhlKQNLAEDAKHKQASVRALKTKWIRRLVLIGIGLGVIQQIAG 280
Cdd:cd06173 176 LFIRRPPP-------------------------------AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 281 INVMMYYGTSILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFASRLPAGSPFr 360
Cdd:cd06173 225 GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAA- 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 361 afatigmmMLFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAATFCLWLANFGVGVLFPIGLAQIGMFWTFVCFIGTNLI 440
Cdd:cd06173 304 --------LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLL 375
|
....*...
gi 489661679 441 SLLFVLIF 448
Cdd:cd06173 376 AALLLLLL 383
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
41-148 |
8.83e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.84 E-value: 8.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 41 GVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRR-LITMLAGLFFLATVASSLSPSAGWLIGAr 119
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRvILVSLVIWIVVCLAAYFLTTALAFWILG- 334
|
90 100
....*....|....*....|....*....
gi 489661679 120 LILGLAVGGVSVLVPSFLAEIAPTSHRGR 148
Cdd:COG2270 335 LLIGLVMGGIQALSRSLLARLIPPGREAE 363
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
61-163 |
1.23e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 47.43 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 61 QGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITmlAGLFFLATVASSLSPSAG----WLIGARLILGLAVGGVSVLVPSF 136
Cdd:TIGR00894 78 QGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIG--IGMFLSSVISIVIPWAAGggiaLVVFCRVIQGLAQGSVSPATHKI 155
|
90 100
....*....|....*....|....*..
gi 489661679 137 LAEIAPTSHRGRLVTqnelMVVTGQLL 163
Cdd:TIGR00894 156 IVKWAPPKERSRLLG----MSTSGFQL 178
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
63-127 |
1.66e-05 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 46.86 E-value: 1.66e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 63 WVTSSLT---LGAAFGAILVGRLSDRYGRRRLitMLAG--LFFLATVASSLSPSAGWLIGARLILGLAVG 127
Cdd:PRK15402 49 WVPTSMTaylAGGMFLQWLLGPLSDRIGRRPV--MLAGvaFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-196 |
2.80e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.01 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFF 100
Cdd:cd17477 185 RLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 101 LATVA-SSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPtshRGRLVTQNELMVVT---GQLLAFVLNAFLGTTFG 176
Cdd:cd17477 265 LAALLlPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLP---GDELVAANAALLLLyglGSVIGPLLAGALMDAFG 341
|
170 180
....*....|....*....|
gi 489661679 177 NvPGIWRWMIVLAVIPAIIL 196
Cdd:cd17477 342 P-HGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-211 |
2.81e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.03 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 62 GWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVlVPSFLAEIA 141
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADIT 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 142 PTSHRgrlvTQNELMVVTGQLLAFVLNAFLGTTFGNVPGIWRWMIVLAVIPAIILGIGTYFVPESPRWLM 211
Cdd:cd17330 116 DEEER----AKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLL 181
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
46-228 |
4.67e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 45.67 E-value: 4.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLI--LG 123
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIqgLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 124 LAVGGVsvlvpsfLAEIAPTSH--RGRLVTQNELM---VVTGQLLAFVLNAFLGTTFGnvpgiWR-WMIVLAVIPAIILG 197
Cdd:PRK11652 110 TGVGGV-------MARTLPRDLyeGTQLRHANSLLnmgILVSPLLAPLIGGLLTTLFG-----WRaCYLFLLLLGAGVTF 177
|
170 180 190
....*....|....*....|....*....|.
gi 489661679 198 IGTYFVPESprwlmmkgRPAAARSSlEVLRS 228
Cdd:PRK11652 178 SMARWMPET--------RPADARRT-RVLAS 199
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
47-232 |
5.09e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 45.32 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 47 LPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVAS-SLSPSAGWLIGARLILGLA 125
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALaLAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 126 VGGVSVLVPsFLAEIAPTSHRGRLVTQNELM----VVTGQLLA---FVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGI 198
Cdd:cd17341 102 GANFASGQP-WASFWFPKEKIGGAAGGIAGAgnmgVAVSQLLApliAGAIVFDGGFVG-----WRNAFFVPGILLAIAAV 175
|
170 180 190
....*....|....*....|....*....|....
gi 489661679 199 GTyfvpesprWLMMKGRPAAARSSLEVLRSAAEV 232
Cdd:cd17341 176 LV--------LLFGDDLPTGKASALEFLKVQLAV 201
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
73-147 |
5.20e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 5.20e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489661679 73 AFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRG 147
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
24-205 |
5.61e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.26 E-value: 5.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 24 LVALISTMGGLLFGYDTGVINGALPfISSELKLAPgsqgwvTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLAT 103
Cdd:cd17323 6 FLTFVVTFGSSIYSPALPQIAEDFH-VSEEVANLG------VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 104 VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWR 183
Cdd:cd17323 79 IGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-----WR 153
|
170 180
....*....|....*....|...
gi 489661679 184 WM-IVLAVIPAIILGIGTYFVPE 205
Cdd:cd17323 154 WIfWFLAIISGFCLILIFLFLPI 176
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-198 |
7.37e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.06 E-value: 7.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRrlITMLAGLFF--LATVASS 107
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPR--VFLPIGLILcaIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 108 LSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVT-QNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMI 186
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSfWNCSHNVGGGLLPPLVLFGIAELYS-----WHWVF 153
|
170
....*....|..
gi 489661679 187 VLAVIPAIILGI 198
Cdd:TIGR00881 154 IVPGIIAIIVSL 165
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-173 |
7.98e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 7.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 62 GWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIA 141
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110
....*....|....*....|....*....|....*.
gi 489661679 142 PTSHRGRLVTQNE----LMVVTGQLLAFVLNAFLGT 173
Cdd:cd17391 323 PKEVAGRIFGYNQsfqyLGNVAGPLLGSAIAAHFGY 358
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
73-390 |
8.27e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.90 E-value: 8.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 73 AFGAILVGRLSD----RYGRRR----LITMLAGLFFLA---TVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIA 141
Cdd:cd17332 49 AINDPLMGYLIDrtrsRWGRFRpwllWGAIPLALLFVLlftTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 142 PTSH-RGRLVTQNELMVVTGQLLAFVLNAFLGTTFG--NVPGIWRWMIVLAVIPAIILGIGTYFvpesprwlmmkgrpaa 218
Cdd:cd17332 129 DDPEeRTSLTSWRMFFATIGGLLVTVLPPPLVAYFGggNASRGYFLTALIIGIIGIILLLICFF---------------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 219 arsslevlrSAAEVPAEIdhlkQNLAEDAKHKQASVRALKTKWIRRLVLIGIGLGVIQQIAGiNVMMYYGTSILQmtgfG 298
Cdd:cd17332 193 ---------GTRERVVPP----EEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVN-TVLVYYFKYVLG----G 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 299 RDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITGVTFAsrlpagsPFRAFATIGMMMLFLAFFQGA 378
Cdd:cd17332 255 RAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFL-------PPGNLVLILVLAVLAGIGYGG 327
|
330
....*....|..
gi 489661679 379 ISPMTWLLMSEI 390
Cdd:cd17332 328 ANLLPWAMLADV 339
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
71-204 |
9.13e-05 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 44.33 E-value: 9.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 71 GAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLV 150
Cdd:cd17446 45 GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVG 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489661679 151 TQNELMVVTGQLLafvlnaFLGTTFGNVPgiWRWMIVLAVIPAIILGIGTYFVP 204
Cdd:cd17446 125 TLLGYCYTLGQLI------LAGVAYAIRD--WRWLQLAVSLPFFIFFLYSWWFP 170
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
70-195 |
1.01e-04 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 44.38 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 70 LGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRL 149
Cdd:cd17445 47 LGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLV 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 489661679 150 VTQNELMVVTGQLLafvlnaFLGTTFGNvpGIWRWMIVLAVIPAII 195
Cdd:cd17445 127 AMAGGLTMVGGHFL------LLGLALGC--GSWRVLQGTITAPLSL 164
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
32-217 |
1.18e-04 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 44.26 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 32 GGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPS 111
Cdd:PRK03633 14 GLLLLTLAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 112 AGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQnELMV-----VTGQLLAFVLNAFLGTTFGNVPGiwrwMI 186
Cdd:PRK03633 94 FWSWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAA-YMMVyylgtVLGQLLVSKVSTELMSVLPWVTG----LV 168
|
170 180 190
....*....|....*....|....*....|....*...
gi 489661679 187 VLAVIPAIIlgigTYFVPESPR-------WLMMKGRPA 217
Cdd:PRK03633 169 LAAILPLLF----TRILNQQAEnhdstsiWPMLKLRQA 202
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
47-208 |
1.34e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.22 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 47 LPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAV 126
Cdd:cd06180 22 LPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 127 GGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGIWRWMIVLAVIPAIILGIGTYFVPES 206
Cdd:cd06180 102 AFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSA 181
|
..
gi 489661679 207 PR 208
Cdd:cd06180 182 PT 183
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
47-208 |
1.41e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.13 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 47 LPFISSELKLAPGSqgwvtSSLTLGAAFGA---------ILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIG 117
Cdd:cd17472 16 LPVLSVYAKSLPGA-----TPTLIGLALGIygltqaifqIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 118 ARLILGLavGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnVPGIWrWMIvlAVIPAIILG 197
Cdd:cd17472 91 GRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLG-VSGLF-LIT--AILSLVSLL 164
|
170
....*....|.
gi 489661679 198 IGTYFVPESPR 208
Cdd:cd17472 165 ILLFFVPDPPK 175
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
70-204 |
1.54e-04 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 43.57 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 70 LGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRgrl 149
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHR--- 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 489661679 150 vTQNELMVVTGQLLAFVLNAFLGTTFGNvpgiWRWMIVLAVIPAIILGIGTYFVP 204
Cdd:cd17447 123 -TVAGVLISLFWTVGNMLLALVAYLIRD----WRWLILAVTLPCAPGIITWWWVP 172
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
66-211 |
1.87e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 43.49 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 66 SSLTLGAAFGAILVGRLSDRYGRRrlITMLAGLFFLAT--VASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPT 143
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRK--VCFLISILGNGVsgVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGS 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489661679 144 SHRgRLVTQNELMVVTGQLLAFVLNAFLGTTfgnvpgiWRWMIVLAVIPAIILGIGTYFVPESPRWLM 211
Cdd:cd17379 118 KYR-RTVGIVYQMFFTLGLLILPGIAYFIPH-------WRWLQLAVTLPNFLFLLYYWFIPKHTFILM 177
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-147 |
1.93e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.44 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 22 LRLVALISTM-GGLLFGYdTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLI---TMLAG 97
Cdd:cd17371 208 LRTTLLASLLaTGALGGY-YGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFalfALGSA 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 489661679 98 LFFLATVASSLSPSAGWLIGarLILGLAVGGVSVLVPSFLAEIAPTSHRG 147
Cdd:cd17371 287 ISILLYFFLPLSPTLILILG--FPLGFFASGPFSGMGAYLTELFPTAVRA 334
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
21-196 |
2.22e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.38 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRY--GRRRLITMLAGL 98
Cdd:cd17475 196 RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 99 FFLATVASSLSPSAG---WLIGARLIL-GLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTT 174
Cdd:cd17475 276 IAAAALLVLSLLSPGtplWLLVLLLILlGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDA 355
|
170 180
....*....|....*....|..
gi 489661679 175 FGNVPGIWRWMIVLAVIPAIIL 196
Cdd:cd17475 356 THSYAPAWLALALLLVLAALLL 377
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
56-132 |
2.24e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.41 E-value: 2.24e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489661679 56 LAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGL-AVGGVSVL 132
Cdd:PRK11551 252 LSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLfVVGGQSVL 329
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
66-204 |
2.60e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 43.05 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 66 SSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSH 145
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRH 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 489661679 146 RGrlvtqnelMVVTGQLLAFVLNAFLGTTFGNVPGIWRWMIVLAVIPAIILGIGTYFVP 204
Cdd:cd17374 122 RA--------LAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP 172
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
69-403 |
2.82e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 43.12 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 69 TLGAAF-----GAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAG----W----LIGARLILGLAVGGVSVLVPS 135
Cdd:cd17366 45 TFAVAFlvrplGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYAtigvWapilLLLARMVQGFSTGGEYGGAAT 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 136 FLAEIAPTSHRGRLVTQNELMVVTGQLLA----FVLNAFLGTTFGNVpgiWRWMI-VLAVIPAIILGIgtyfvpesprwl 210
Cdd:cd17366 125 FVAEYAPDRKRGFLGSWLEFGTLAGFILGaglvTLLTLLLTEAQMLD---WGWRIpFLIAAPLGLVGL------------ 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 211 mmkgrpaaarsslevlrsaaevpaeidhlkqnlaedakhkqasvralktkWIRRLVLIGIGLGVIQQIAGINVMMYYGTS 290
Cdd:cd17366 190 --------------------------------------------------YLRRPLLICIGLVLVFNVTNYMLLSYMPSY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 291 ILQMTGFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAitGVTFASRLPAGSPFRAFATIGMMML 370
Cdd:cd17366 220 LEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVL--AVPAFLLMNSGSIAAIFIGLLVLGL 297
|
330 340 350
....*....|....*....|....*....|...
gi 489661679 371 FLAFFQGAISPmtwlLMSEIFPEQVRGIGMGAA 403
Cdd:cd17366 298 LLSCYTATMAS----TLPALFPTHVRYSALAIA 326
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
60-418 |
3.18e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 60 SQGWVTSSLTLG---AAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLIL-GLAVGGVSVLVPS 135
Cdd:cd17355 36 SRAVISLAFTVGllaFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 136 FLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGnvpgiWRWMIVLAVIPAIILGIgtyfvpesPRWLMMKGR 215
Cdd:cd17355 116 TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG-----WRTALLVLALLALLVLV--------PVLLLLRRR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 216 PAaarsslevlrsaaevpaeidHLKQNLAEDAKHKQASVRALKTKWIRRLVLIGIGLGVIqqIAGINVMMYYGTSILQMT 295
Cdd:cd17355 183 PA--------------------DLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLC--GFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 296 GFGRDSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIVGLIGSTVAITgvtfasrLPAGSPFRAFATIGMMMLFlAFF 375
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA-------LLLLLPFPPLALLLFAALF-GLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489661679 376 QGAISPMTWLLMSEIFPEQ----VRGIGMGAATFCLWLANFGVGVLF 418
Cdd:cd17355 313 WGATVPLTAALAARYFGARsygtLFGLVFAPHQLGSALGPWLGGLLY 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-196 |
3.36e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.80 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 21 RLRLVALISTMGGLLFGydtGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFF 100
Cdd:cd06174 204 GLWLLLLAIFLVNLAYY---SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 101 -LATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVP 179
Cdd:cd06174 281 aLGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360
|
170
....*....|....*..
gi 489661679 180 GIWRWMIVLAVIPAIIL 196
Cdd:cd06174 361 GAFLVLAVLLLLAAILL 377
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
56-196 |
3.70e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 3.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 56 LAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVA-SSLSPSAGWLIGARLILGLAVGGVSVLVP 134
Cdd:cd17355 242 ISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALlLLLPFPPLALLLFAALFGLGWGATVPLTA 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489661679 135 SFLAEIAPTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGIWRWMIVLAVIPAIIL 196
Cdd:cd17355 322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
26-213 |
4.85e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.22 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 26 ALISTMGGLLF-GYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATV 104
Cdd:PRK12307 19 ALFSAWLGYVFdGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 105 ASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTShrgrLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPGiWRW 184
Cdd:PRK12307 99 LSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKH----LKSKASAFLVSGFGIGNIIAAYFMPSFAEAYG-WRA 173
|
170 180
....*....|....*....|....*....
gi 489661679 185 MIVLAVIPAIILGIGTYFVPESPRWLMMK 213
Cdd:PRK12307 174 AFFVGLLPVLLVIYIRARAPESKEWEEAK 202
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
64-204 |
6.10e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 42.07 E-value: 6.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 64 VTSSLTLGAAF-GAILVGRLSDRYGRRRLitMLAGLFF--LATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEI 140
Cdd:cd17377 43 LASSFFFAGVLiGVVSFGQLSDRFGRKPV--YLTGLALdiLFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNEC 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489661679 141 APTSHRGRLVTQNELMVVTGqllaFVLNAFLGTTFGNvpgiWRWMIVLAVIPAIILGIGTYFVP 204
Cdd:cd17377 121 VGKSYWALAGSLGGLFFAVG----IAQYALLGYFIRS----WRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
69-413 |
7.03e-04 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 41.85 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 69 TLGAAF-----GAILVGRLSDRYGRRR-----LITMLAGLFFLATVAS----SLSPSAGWLIGaRLILGLA----VGGVS 130
Cdd:PRK15075 61 VFGAGFlmrplGAIVLGAYIDRVGRRKglivtLSIMASGTLLIAFVPGyatiGLAAPLLVLLG-RLLQGFSagveLGGVS 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 131 VlvpsFLAEIAPTSHRGRLVT----QNELMVVTGQLLAFVLNAFLGttfGNVPGIWRWMIVLAVIPAIILGIgtyFV--- 203
Cdd:PRK15075 140 V----YLAEIATPGRKGFYTSwqsaSQQVAVVFAALLGYLLNQWLS---PAQMAEWGWRIPFLIGCLIVPFI---FLirr 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 204 --PESPRWLMMKGRPAAArsslEVLRSAAEvpaeidhlkqnlaedakhkqasvralktKWirRLVLIGIGLGVIQQIAGI 281
Cdd:PRK15075 210 slEETEEFLARKHRPSMR----EIFRSLAA----------------------------NW--RIVLAGMLMVAMTTVSFY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 282 NVMMY---YGTSILQMTGFgrdSALIANIANGVTAVAATIVTLQLLKHVPRRPMLIvgligstvAITGVTFASRLPAGSP 358
Cdd:PRK15075 256 LITVYtptFGKTVLHLSAA---DSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLI--------AFTVLAILTAYPALSW 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489661679 359 FRAFATIGMMM---LFLAFFQGAISPMTWLLMSEIFPEQVRGIGMGAAtFCLWLANFG 413
Cdd:PRK15075 325 LVAAPSFARMLaveLWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLA-YSLATAIFG 381
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
43-446 |
7.07e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 7.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 43 INGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAglFFLATVASSLSPSAGWLIGARLIL 122
Cdd:cd17370 18 ARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILG--YGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 123 GLAVGGVSVLVPS---FLAEIAPTSHRGRLVTQNELM----VVTGQLLAFVLNAFLGTTFgnvpgiwRWMIVLAVIPAII 195
Cdd:cd17370 96 ILERLGKGIRTPPrdaLLADATPPSGRGKAFGLHRALdtlgAVLGPLLAALLLYLLGGNY-------RTIFLLAAIPALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 196 -LGIGTYFVPESPRwlmmkgrpaaarsslevlrsaaevpaeidhlkqnlAEDAKHKQASVRALKTKWIRRLVLIGIGLGV 274
Cdd:cd17370 169 aLLILLFVVKEYPR-----------------------------------PPKLRKKSKKTSLKKLPKAFWLYLLAVALFA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 275 iqqIAGINVMMYygtsILQMTGFGRDSALIA---NIANGVTAVAATIVTLqLLKHVPRRPMLIVGLIgsTVAITGVTFAS 351
Cdd:cd17370 214 ---LGNFSFAFL----ILRAQELGLSAALIPllyALFNLVYALAAYPAGR-LSDRIGRKKLLILGYL--SLALAYLGFAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 352 RLPAGSPFRAFATIGmmmLFLAFFQGAISPMtwllMSEIFPEQVRGIGMGAATF----CLWLANFGVGVLFPiglaQIGM 427
Cdd:cd17370 284 GSSLWLLLLGFILWG---LYMGAQESIERAA----VADLVPAELRGTAYGLFNTvvgiGWLLASLIAGYLWD----LISP 352
|
410
....*....|....*....
gi 489661679 428 FWTFVCFIGTNLISLLFVL 446
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
67-163 |
1.51e-03 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 40.58 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 67 SLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSHR 146
Cdd:cd17373 33 SLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKR 112
|
90
....*....|....*..
gi 489661679 147 GRLVTQNELMVVTGQLL 163
Cdd:cd17373 113 LMITMVASLVAVAGQFL 129
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-130 |
1.84e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 48 PFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLitMLAGLFFLATVASSLSPSAG-WLIGARLILGLAV 126
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV--LAVGLLLMGAAALLMALVGSyPVLLVLLFLVGAG 97
|
....
gi 489661679 127 GGVS 130
Cdd:cd17475 98 YGSV 101
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
75-401 |
2.05e-03 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 40.56 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 75 GAILVGRLSDRYGRRR--------------LITMLAGLFFLATVASSLspsagwLIGARLILGLAVGGVSVLVPSFLAEI 140
Cdd:PRK10406 79 GGWLFGRIADKHGRKKsmlisvcmmcfgslVIACLPGYETIGTWAPAL------LLLARLFQGLSVGGEYGTSATYMSEV 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 141 APTSHRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVP-GIWRWMIVLAVIPAIilgigtyfvpesprwlmmkgrpaaA 219
Cdd:PRK10406 153 AVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQTLEDAElREWGWRIPFALGAVL------------------------A 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 220 RSSLEVLRSAAEVPAeidhlkqnlAEDAKHKQASvrALKTKWIRRLVLIgiglGVIQQIAGINVMMYYGTSILQMTgFGR 299
Cdd:PRK10406 209 VVALWLRRQLDETSQ---------QETRALKEAG--SLKGLWRNRRAFI----MVLGFTAAGSLCFYTFTTYMQKY-LVN 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 300 DSALIANIANGVTAVAATIVTL------QLLKHVPRR-PMLIvglIGSTVAITGVTFASRLP-AGSPFRAFATIgMMMLF 371
Cdd:PRK10406 273 TAGMHANVASGIMTAALFVFMLiqpligALSDKIGRRtSMLC---FGSLAALFTVPILSALQnVSSPYAAFGLV-MCALL 348
|
330 340 350
....*....|....*....|....*....|
gi 489661679 372 LAFFQGAISPmtwLLMSEIFPEQVRGIGMG 401
Cdd:PRK10406 349 IVSFYTSISG---ILKAEMFPAQVRALGVG 375
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
30-202 |
2.56e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 30 TMGGLLFGYDTGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLS 109
Cdd:cd17476 4 SGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 110 PSAGWLIGARLILGLavgGVSVLVPSFLAEIAPTSHRGRLvtQNELMVVTGQL--LAFVLNAFLGTTFGNvPGIWRWMIV 187
Cdd:cd17476 84 PNFIFFIICRALQGL---GPAFLLPNAMALLGRTYPPGPR--KNIVFSLFGATapLGFALGGVFGGLFAQ-LAWWPWIFW 157
|
170
....*....|....*
gi 489661679 188 LAVIPAIILGIGTYF 202
Cdd:cd17476 158 FLAILAAIVAVAAIF 172
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
60-121 |
2.68e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.88 E-value: 2.68e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489661679 60 SQGWVTSSLTL---GAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAGWLIGARLI 121
Cdd:PRK11043 39 SASAVSASLSLflaGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFV 103
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
49-146 |
3.49e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 39.65 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 49 FISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLI-TMLAGLFFLATVASSL--SPSAGWLIGARLILGLA 125
Cdd:cd17366 219 YLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYaAGLAGLLVLAVPAFLLmnSGSIAAIFIGLLVLGLL 298
|
90 100
....*....|....*....|.
gi 489661679 126 VGGVSVLVPSFLAEIAPTSHR 146
Cdd:cd17366 299 LSCYTATMASTLPALFPTHVR 319
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-208 |
4.61e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 40 TGVINGALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLitMLAGLFFLATVASSL--SPSAGWLIG 117
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYL--LPLGPLLTGLGLSLLgfAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 118 ARLILGLAVGGVSVLVPSFLAEIAPTShRGRLVTQNELMVVTGQLLAFVLNAFLGTTFGNVPgiwrwMIVLAVIPAIILG 197
Cdd:cd17478 90 LVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG-----LLILLIIPGLAVA 163
|
170
....*....|.
gi 489661679 198 IGTYFVPESPR 208
Cdd:cd17478 164 LLLLRLRPLKK 174
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
77-227 |
5.15e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.21 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 77 ILVGRLSDRYGRRR-------LITMLAGLFFLATVASSLSPSAGWLIGARLILGLAVGGVSVLVPSFLAEIAPTSH-RGR 148
Cdd:pfam13347 55 HIIDRTRTRWGRRRpwlllsaIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDeRTS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 149 LVTQNELMVVTGQL----LAFVLNAFLGTTFGNVPGIWRWMIVLAVIPAIILGIGTYFVPESPRwlMMKGRPAAARSSLE 224
Cdd:pfam13347 135 LTSYRSFFSVGGGLlaaaLAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVS--MRSKEDTGQKEAGS 212
|
...
gi 489661679 225 VLR 227
Cdd:pfam13347 213 LLD 215
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
46-185 |
5.70e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 46 ALPFISSELKLAPGSQGWVTSSLTLGAAFGAILVGRLSDRYGRRRLITMLAGLFFLATVASSLSPSAG--WLIGARLILG 123
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSlpLLILSRILLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 124 LAVGgvsVLVPSF---LAEIAPTSHRGRLVTqnelmVVT-----GQLLAFVLNAFLGTTFGnvpgiWRWM 185
Cdd:cd17380 101 LGEG---VHFPSMtslFSRWVPVSERSRAVS-----IVTagsylGTLLGGLIGPLLLEYYG-----WPSV 157
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
62-148 |
8.30e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.39 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489661679 62 GWVTSSLTLGAAFGAILVGRLSDRYGRRRLITM-LAGlFFLATVASSLSPSAGWLIGARLILGLaVGGVSVLVPSFLAEI 140
Cdd:cd17388 41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLsLAG-AALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADV 118
|
....*...
gi 489661679 141 APTSHRGR 148
Cdd:cd17388 119 TPPEQRAR 126
|
|
| |
