|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11195 |
PRK11195 |
lysophospholipid transporter LplT; Provisional |
1-420 |
0e+00 |
|
lysophospholipid transporter LplT; Provisional
Pssm-ID: 236879 [Multi-domain] Cd Length: 393 Bit Score: 556.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 1 MKRGFYLVMAAQAFSSLADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFITNALKVA 80
Cdd:PRK11195 1 MSKGFYAIMAAQFFSALADNALLFAAIALLKELHYPDWSQPLLQMFFVLAYIVLAPFVGAFADSFPKGRVMFIANGIKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 81 GCMLMFsyasIGVPAtyqtylvCAAYGLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLIS 160
Cdd:PRK11195 81 GCLLML----FGIHP-------LLAYGLVGIGAAAYSPAKYGILTELLPGEKLVKANGWMEGSTIAAILLGTVLGGALAD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 161 PHvssvllahpwlnklvhtpAEAAILVIALVYVIAALCNLLIPPTHVRYPPQQRSPFKLVRAFSGYVCVLWRDKLGQISL 240
Cdd:PRK11195 150 PH------------------AEAALAVCALIYLLAALFNLFIPRLGARRPGQSWNPIALLRDFFHACRVLWRDKLGRFSL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 241 AVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVGSILAGR-IPLRKALSVLPVGAAMGLVVLLMPLVY 319
Cdd:PRK11195 212 AGTTLFWGAGATLRFLVLAWAPVALGITLNQPAYLQAVVAIGIAVGAGAAARlVTLETVLRVLPAGILMGLVVLLMALQH 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 320 SPWSVYLLLLVTGGLAGFFVVPMNALLQHRGHVLLSAGHSIAVQNFNEQLNILLMVAIYTVLLWLELPINIIIVIFGLIV 399
Cdd:PRK11195 292 SLLPAYPLLILIGALGGFFVVPMNALLQHRGHVLVGAGHSIAVQNFNENLAMLLMLGLYSLLVKLGVPVVAVIVGFGLLV 371
|
410 420
....*....|....*....|.
gi 489910465 400 TVLMVVFIRWSRRNLSADPAL 420
Cdd:PRK11195 372 ALAMALLWRWHRRNQRQFDSV 392
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
47-408 |
1.30e-48 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 178.19 E-value: 1.30e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 47 FALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCMLMFSYASIGVPatyqtYLVCAAYGLVGIGAAAYSPAKYGIVTE 126
Cdd:PRK08633 56 FLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWF-----WLAFAVTFLLGAQSAIYSPAKYGIIPE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 127 MLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVL---ISPHVSSVLLAHPWlnklvhtPAEAAILVIALVYVIAAlcnLLIP 203
Cdd:PRK08633 131 LVGKENLSRANGLLEAFTIVAILAGTALFSFLfesVNGNTPSEILGRIA-------PAGLVLLAVAVLGLIFA---YRLP 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 204 PTHVRYPPQ-QRSPFKLVRAFSGYVCVLWRDKLgqISLAVT--TLFWGAGATLQLIVIEWGRSHLGY-RLDQASVLMGVA 279
Cdd:PRK08633 201 KVPAAAPEVfDKKKYLFPKLLWRNLKLLRSDRV--LWLAIIglSYFWFISQLAQANFPAYAKEVLGLdNTFQVQYLLAAS 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 280 AVGTVVGSILAGRIPLRK-ALSVLPVGAA-MGLVVLLMPLVYSPWSVYLLLLVTGGLAGFFVVPMNALLQHRG--HVLls 355
Cdd:PRK08633 279 AIGIGIGSLLAGRLSGRHiELGLVPLGALgLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRApeKEL-- 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489910465 356 aGHSIAVQNFNEQLNILLMVAIYTVLLWLELPINIIIVIFGLIVTVLMVVFIR 408
Cdd:PRK08633 357 -GKVLAANNFLQNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLIGTLYTLL 408
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-408 |
5.16e-35 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 133.51 E-value: 5.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 5 FYLVMAAQAFSSLADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCML 84
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 85 MFSYASIGVPATYQTYLVCAaygLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISphvs 164
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAF---LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 165 svllahpwlnklvHTPAEAAILVIALVYVIAALCNLLIPPTHVryPPQQRSPFKLVRAFSGYVCVLWRDKLGQISLAVTT 244
Cdd:cd06173 154 -------------LLGPGGAFAINALSFLLSALLLLFIRRPPP--AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 245 LFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVGSILAGRIPLRKALSVLPVGAA--MGLVVLLMPLVYSPW 322
Cdd:cd06173 219 LFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGAllLGLALLVLGLSPSLW 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 323 SVYLLLLVTGGLAGFFVVPMNALLQHRGHVLLsAGHSIAVQNFNEQLNILLMVAIYTVLLWLeLPINIIIVIFGLIVTVL 402
Cdd:cd06173 299 LLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL-RGRVFSVYNALNSGAMPLGALLAGLLADA-LGLSAVFLLAGALLLLA 376
|
....*.
gi 489910465 403 MVVFIR 408
Cdd:cd06173 377 ALLLLL 382
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
3-407 |
2.35e-23 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 103.12 E-value: 2.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 3 RGFYLVMAAQAFSSLADNALFIAAIALIL-ELSG-----PDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFITNA 76
Cdd:PRK06814 11 RRFAPLFWTQFFGAFNDNFLKNALVILILyGLSGalgayNNALVTLAGAVFILPFFIFSALAGQLADKYDKAKLAKILKF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 77 LKVAGCMLM---FSYASIgvpatyqtYLVCAAYGLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTV 153
Cdd:PRK06814 91 AEIGIAALAiygFHLNSV--------PLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLGTI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 154 LGGVLISPHVSSVLLAhpwlnklvhtpaeaaiLVIALVyVIAALCNLLIPPTHVrYPPQQRSPFKLVRAFSGYVCVLWRD 233
Cdd:PRK06814 163 IGGLATISGNFVILVA----------------LLMGIA-VLGWLASLFIPKTGN-AAPDLKIDRNIIRSTITLLKYAKAD 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 234 KlgQISLAV--TTLFWGAGAT----LQLIVIEwgrsHLGYRLDQASVLMGVAAVGTVVGSILAGRI-PLRKALSVLPVGA 306
Cdd:PRK06814 225 K--RIWLAIlgISWFWLVGAVvlsqLPLLAKE----TLGGDENVATLFLAVFSVGVAVGSFLASKLsEGRITLLYVPIGA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 307 A-MGLVVLLMPLVYSP--------------------WSVYLLLLVTGGLAGFFVVPMNALLQHRGHVLLSAgHSIAVQNF 365
Cdd:PRK06814 299 LlMGLFGLDLAFASSSvpaepaqlksilvflskrhgWRILIDLFGLAAAGGLYIVPLFAALQAWANPAHRA-RVIAANNV 377
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489910465 366 neqLNILLMVA---IYTVLLWLELPINIIIVIFG---LIVTVLMVVFI 407
Cdd:PRK06814 378 ---LNAAFMVAgtiILALLQALGFSIPWIILFIAlanLIVAILILRLL 422
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-349 |
4.83e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.94 E-value: 4.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 2 KRGFYLVMAAQAFSSLADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFItnalkvag 81
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL-------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 82 CMLMFSYASIGVPATYQTYLVCAAYGLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISp 161
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 162 hvssvllahpwlnklvHTPAEAAILVIALVYVIAALCNLL-IPPTHVRYPPQQRSPFKlvrafsgyvcVLWRDKLGQISL 240
Cdd:COG2814 160 ----------------LFGWRWVFLVNAVLALLALLLLLRlLPESRPAARARLRGSLR----------ELLRRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 241 AVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVGSILAGRIPLRKALSVLPVGA--AMGLVVLLMPLV 318
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGllLLALGLLLLALA 293
|
330 340 350
....*....|....*....|....*....|.
gi 489910465 319 YSPWSVYLLLLVTGGLAGFFVVPMNALLQHR 349
Cdd:COG2814 294 GSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
46-346 |
2.44e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.90 E-value: 2.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 46 SFALAYVVLAAFVGAFADSFPKgRVMFITNALKVAGCMLMFSYASigvpaTYQTYLVcaAYGLVGIGAAAYSPAKYGIVT 125
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAVSTLLFAFAT-----SYWQLLL--ARFLQGLASAAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 126 EMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISphvssvllahpwlnklvHTPAEAAILVIALVYVIAALCNLLIPPT 205
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD-----------------ALGYRAPFLVCAALALLALVLALLLLPE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 206 HVRYPPQQRSPFKLVRAFSGyvcVLWRDKLGQISLAVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVV 285
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLR---LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489910465 286 GSILAGRIPLRK-ALSVLPVGAA-MGLVVLLMPLVYSPWSVYLLLLVTGGLAGFFVVPMNALL 346
Cdd:cd17325 251 SQPPAGKLSDRIgRKPLILIGLLlSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-365 |
1.37e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.44 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 17 LADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCMLMFSYASIgvpat 96
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF----- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 97 yqtYLVCAAYGLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISPHVSSVLlahpwlnkl 176
Cdd:cd06174 85 ---WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR--------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 177 vhtpaeAAILVIALVYVIAALCNLLIPPTHVRYPPQQRSPFKLVRAFSGYVCVLWRDKLGQISLAvTTLFWGAGATLQLI 256
Cdd:cd06174 153 ------AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLA-IFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 257 VIEWGRSHLGYRLDQASVLMGVAAVGTVVGSILAGRIPLRKA--LSVLPVGAAMGLVVLLMPLVYSPWSVYLLLLVTGGL 334
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIgrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGF 305
|
330 340 350
....*....|....*....|....*....|.
gi 489910465 335 AGFFVVPMNALLQHRGHVLLSAGHSIAVQNF 365
Cdd:cd06174 306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNT 336
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
47-349 |
1.69e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.97 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 47 FALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCMLMFSYASIgvpatyqtYLVCAAYGLVGIGAAAYSPAKYGIVTE 126
Cdd:pfam07690 41 FSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALALIAD 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 127 MLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISphvssvllahpwlnklvHTPAEAAILVIALVYVIAALCNLLipPTH 206
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-----------------LFGWRAAFLILAILSLLAAVLLLL--PRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 207 VRYPPQQRSPFKLVRAFSGYVCVLWRDKLGQISLAVTTLFWGAGATLQLIVIEwgRSHLGYRLDQASVLMGVAAVGTVVG 286
Cdd:pfam07690 174 PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY--QEVLGLSALLAGLLLGLGGLLGAIG 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489910465 287 SILAGRI-----PLRKALSVLPVGAAMGLVVLLMPLVYSPWSVYLLLLVTGGLAGFFVVPMNALLQHR 349
Cdd:pfam07690 252 RLLLGRLsdrlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
57-343 |
1.95e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 57 FVGAFADSF--PKGR---VMFITNALKVAGCMLMFSyaSIGVPATYQTYLVCAAYGLVGIGAAAYSPAKYGIVTEMLP-P 130
Cdd:COG2211 65 LIGALSDRTrtRWGRrrpWILIGAIPLALSFVLLFT--APDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdY 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 131 DLLVKGNSWIEGLTVLSIIIGTVLGGVLISphvssvllahpWLNKLVHTPAEAAILVIALVYVIAALCNLLIPPTHVRYP 210
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVA-----------AFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 211 PQQRSPFKLVRAfsgyvcvLWRDKLGQISLAVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVGSILA 290
Cdd:COG2211 212 EEKVSLKESLKA-------LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489910465 291 G----RIPLRKALSVLPVGAAMGLVVLLMPLVYSPWSVYLLLLVTG-GLAGFFVVPMN 343
Cdd:COG2211 285 PrlakRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGiGLGAILVLPWA 342
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-351 |
1.17e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.24 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 47 FALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCMLMFSYASIGVpatyqtylVCAAYGLVGIGAAAYSPAKYGIVTE 126
Cdd:cd17324 43 YALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--------LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 127 MLPPDLLVKGNSWIEGLTVLSIIIGTVLGGvLISPHVSsvllahpWlnklvhtpaEAAILVIALVYVIAALCNLLIPPTH 206
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLG-------W---------RAAFLAIAVLALLAALLLWRLLPSL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 207 VRYPPQQRSPFKLVRAfsgyvcvLWRDKLGQISLAVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVG 286
Cdd:cd17324 178 PPKKPGSLGLLSSLLL-------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489910465 287 SILAGRIPLRKALSVLPVGAA--MGLVVLLMPLVYSPWSVYLLLLVTGGLAGFFVVPMNALLQHRGH 351
Cdd:cd17324 251 SPLAGRLADRGGRRALLIALLllAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-348 |
2.69e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.16 E-value: 2.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 46 SFALAYVVLAAFVGAFADSFPKGRVMfitnalkvAGCMLMFSYASIGVPATYQTYLVCAAYGLVGIGAAAYSPAKYGIVT 125
Cdd:cd17328 42 VFIISYMVLSPIFGYLGDRYNRKWIL--------AVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 126 EMLPPDLLVKGNSWIegltVLSIIIGTVLGGVLISPHVSSVLlahPWLNKLVHTPAEAAILVIALVyviaalcnLLIPPT 205
Cdd:cd17328 114 DLFPKEKRTRALGVF----YFAIPLGSGLGYVVGGLVAQATG---GWRWAFRVTGVLGVLLAILLL--------LFVREP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 206 HVRYPPQQRSPFKLVRAFSGYVCVLWRDK-LGQISLAVTTLFWGAGATLQ--LIVIEWGRSHLGYRLDQASVLMGVAA-- 280
Cdd:cd17328 179 PRGAAEGGVMAKSTATSFLADLKALAKNPsFILSTLGFTAVSFVTGALAFwaPTFFLRAFGVGDLSSADVGLIFGAITci 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489910465 281 ---VGTVVGSILAGRIPlRKALSVLPVGAAMGL-------VVLLMPLVYSPWSVYLLLLVTGGLAGFFVVPMNALLQH 348
Cdd:cd17328 259 agvLGVLLGGILADRLR-RKTPRADPLVCAVGLlaaapflFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLY 335
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-347 |
1.24e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 7 LVMAAQAFSSLADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFItnalkvagCMLMF 86
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI--------GLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 87 SYASIGVPATYQTYLVCAAYGLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISphvssv 166
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA------ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 167 llAHPWlnklvhtpaEAAILVIALVYVIAALCNLLIppthvryppqqrspfklvrafsgyvcvlwrdkLGQISLAVTTLF 246
Cdd:COG2271 160 --AFGW---------RAAFLILGLPGLLLALLRFWL--------------------------------LALAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 247 WGAGATLQLIVIEwgrsHLGYRLDQASVLMGVAAVGTVVGSILAG----RIPLRKALSVLPVGAAMGLVVLLMPLVYSPW 322
Cdd:COG2271 197 YGFLTWLPTYLVE----VRGLSLAQAGLLLSLPFLAGIVGSLLGGwlsdRLGRRRKLVLAIGLLLAALALLLLALLPSPA 272
|
330 340
....*....|....*....|....*
gi 489910465 323 SVYLLLLVTGGLAGFFVVPMNALLQ 347
Cdd:COG2271 273 LAIALLFLAGFGLGGAFGLLWALAA 297
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
48-337 |
2.74e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 48 ALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCMLMFSYASIgvpatyqtYLVCAAYGLVGIGAAAYSPAKYGIVTEM 127
Cdd:cd17329 45 AVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP--------WLFAIALVLTGFGGGLFEPASEAMIADV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 128 LPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISPHVSSVLLAhpwlnklvhtpaeaailvIALVYVIAALCNLLIPPTHV 207
Cdd:cd17329 117 TTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA------------------AAVLFLLAALVLLFLLPETR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 208 RYPPQQRSPfklvRAFSGYVCVLwRDKLGQISLAVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVGS 287
Cdd:cd17329 179 PKRRAAEKT----EILRGYKIVL-RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 489910465 288 I----LAGRIPLRKALSVLPVGAAMGLVVLLMPLVYSPWSVYLLLLVTGGLAGF 337
Cdd:cd17329 254 FpvarLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVF 307
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
47-346 |
3.61e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 47 FALAYVVLAAFVGAFADSFPKGRVMFITNALKVAGCMLMfsyasiGVPATYQTYLVCAAYGLVGIGAAAYSPAKYgiVTE 126
Cdd:COG2223 49 PVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL------ALAVSYWLLLLLGLLLGIGGGGSFAVGIAL--VSK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 127 MLPPDLLvkgnSWIEGLTVLsiiiGTVLGGVLISPHVSSVLLAHPWlnklvhtpaEAAILVIALVYVIAALCN-LLIPPT 205
Cdd:COG2223 121 WFPPDRR----GLALGLAAG----GGNLGAAVAAFLAPLLIAAFGW---------RNAFLILGILLLVVAVLAwLFLRDP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 206 HVRYPPQQRSPFKLVRAfsgyvcvLWRDKLGQISLAVTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMG----VAAV 281
Cdd:COG2223 184 PAGAAAAAKASLRDQLE-------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAAlfalLGAL 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489910465 282 GTVVGSILAGRIPLRKALSVLPVGAAMGLVVLLMPLvYSPWSVYLLLLVTGGLAGFFVVPMNALL 346
Cdd:COG2223 257 GRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-338 |
7.03e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.76 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 1 MKRGFYLVMAAQAFSSLADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFITNALKVA 80
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 81 GCMLMFSYASIgvpatyqtYLVCAAYGLVGIGAAAYSPAKYGIVTEmLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLIS 160
Cdd:COG0738 86 GLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 161 PHVSSvllahpwlnkLVHTPaeaaILVIALVYVIAALCNLLIPPTHVRYPPQQRSPFKLVRAFsgyvcvLWRDKlgQISL 240
Cdd:COG0738 157 LGLSL----------SWHLP----YLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKS------LLKNP--RLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 241 AVTTLFWGAGA--TLQLIVIEWGRSHLGYRLDQA----SVLMGVAAVGTVVGSILAGRIPLRKALSVLPVGAAMGLvVLL 314
Cdd:COG0738 215 GGLAIFLYVGAegAIGDWLPLYLKDVLGLSEATAalglSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL-LLA 293
|
330 340
....*....|....*....|....
gi 489910465 315 MPLVYSPWSVYLLLLVTGGLAGFF 338
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMF 317
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-309 |
3.01e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 2 KRGFYLVMAAQAFSSLADNALFIAAIALILELSGPDWMAPMMKWSFALAYVVLAAFVGAFADSFPKGRVMFITnalkvag 81
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 82 cMLMFSYASIGVPATYQTYLVCAAYGLVGIGAAAYSPAKYGIVTEMLPPDLLVKGNSWIEGLTVLSIIIGTVLGGVLISp 161
Cdd:COG0477 86 -LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910465 162 hvssvllahpwlnklvHTPAEAAILVIALVYVIAALCNLLIPPTHVRYPPQQRSPFKLVRAFSGYVCVLWRDKLGQISLA 241
Cdd:COG0477 164 ----------------ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489910465 242 VTTLFWGAGATLQLIVIEWGRSHLGYRLDQASVLMGVAAVGTVVGSILAGRIPLRKALSVLPVGAAMG 309
Cdd:COG0477 228 ALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| |
