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Conserved domains on  [gi|490346731|ref|WP_004226713|]
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indole-3-glycerol phosphate synthase TrpC [Lysinibacillus capsici]

Protein Classification

indole-3-glycerol phosphate synthase TrpC( domain architecture ID 10000629)

indole-3-glycerol-phosphate synthase (IGPS) TrpC is an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water

CATH:  3.20.20.70
EC:  4.1.1.48
Gene Ontology:  GO:0004425|GO:0000162
SCOP:  4003071

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-254 7.42e-122

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 439904  Cd Length: 257  Bit Score: 347.79  E-value: 7.42e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   2 NILNKILLQKKIEVgALLEQPDPLANFTE-----TPRRSLFESLCQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYA 76
Cdd:COG0134    2 TILDKIVAHKREEV-AARKARVPLAELEAraaaaPPPRDFAAALRAAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  77 LAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLG 156
Cdd:COG0134   81 AGGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 157 LEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDDAKLVASMGASGVL 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIP--ADVLVVSESGIRTPEDVARLAAAGADAFL 238

                        250
                 ....*....|....*...
gi 490346731 237 VGEALMRSGDAGQALRDL 254
Cdd:COG0134  239 VGEALMRAPDPGAALREL 256
 
Name Accession Description Interval E-value
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-254 7.42e-122

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 347.79  E-value: 7.42e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   2 NILNKILLQKKIEVgALLEQPDPLANFTE-----TPRRSLFESLCQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYA 76
Cdd:COG0134    2 TILDKIVAHKREEV-AARKARVPLAELEAraaaaPPPRDFAAALRAAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  77 LAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLG 156
Cdd:COG0134   81 AGGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 157 LEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDDAKLVASMGASGVL 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIP--ADVLVVSESGIRTPEDVARLAAAGADAFL 238

                        250
                 ....*....|....*...
gi 490346731 237 VGEALMRSGDAGQALRDL 254
Cdd:COG0134  239 VGEALMRAPDPGAALREL 256
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-254 4.35e-119

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 340.60  E-value: 4.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   1 MNILNKILLQKKIEVgALLEQPDPLANFTE-----TPRRSLFESLCQAQtLQVIAEMKRASPSKGLIAGGADPVAQAKVY 75
Cdd:PRK00278   2 MDILDKIVAYKREEV-AARKAQVPLAELKAraaaaPPPRDFAAALRAGK-PAVIAEVKKASPSKGVIREDFDPVEIAKAY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  76 ALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGL 155
Cdd:PRK00278  80 EAGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 156 GLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDDAKLVASMGASGV 235
Cdd:PRK00278 160 GLDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIP--SDRLVVSESGIFTPEDLKRLAKAGADAV 237

                        250
                 ....*....|....*....
gi 490346731 236 LVGEALMRSGDAGQALRDL 254
Cdd:PRK00278 238 LVGESLMRADDPGAALREL 256
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 38-254 6.51e-110

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 315.94  E-value: 6.51e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  38 ESLCQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMI 117
Cdd:cd00331    3 AALKRPGGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDFII 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 118 DRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERT 197
Cdd:cd00331   83 DPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLNTT 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490346731 198 REIANVFPfdENRVLISESGIWTQDDAKLVASMGASGVLVGEALMRSGDAGQALRDL 254
Cdd:cd00331  163 ERLAPLIP--KDVILVSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALREL 217
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
4-253 2.14e-101

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 295.74  E-value: 2.14e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731    4 LNKILLQKKIEVGALLEQPdPLANFTET----PRRSLFESLCQ-AQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYALA 78
Cdd:pfam00218   1 LEKIVADKRAEVAARKARP-PLADLQAAarapPTRSFYDALREsRGRPALIAEVKKASPSKGLIREDFDPAEIARVYEAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   79 GAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLE 158
Cdd:pfam00218  80 GASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGME 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  159 VLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPFDenRVLISESGIWTQDDAKLVASMGASGVLVG 238
Cdd:pfam00218 160 VLVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPAD--VLLVAESGIYTPADVRELKEHGANAFLVG 237

                         250
                  ....*....|....*
gi 490346731  239 EALMRSGDAGQALRD 253
Cdd:pfam00218 238 ESLMRQEDVRAAIRE 252
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
48-254 1.17e-45

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 153.60  E-value: 1.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  48 VIAEMKRASPSkgliAGG---ADPVAQAKVYALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIrf 124
Cdd:NF041303  49 VIAEVKPTSPT----TDGtrdDDPVELAEAMVAGGAAALSVLTEPEHFGGSPETLRRVREAVDVPVLRKDFLLREAQL-- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 125 aKAAGASIILLIVAALTDDaLRDLYSYATGLGLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVF 204
Cdd:NF041303 123 -DAVEADVVLLIARFVGDD-LEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLAKLEVDLGTFESVAPHV 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 490346731 205 PfDENRVLISESGIWTQDDAKLVASMGASGVLVGEALMrSGDAGQALRDL 254
Cdd:NF041303 201 P-DDDVTLIAESGISTPADVRRMREAGADALLVGSAIM-DGDVRENTRRL 248
 
Name Accession Description Interval E-value
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-254 7.42e-122

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 347.79  E-value: 7.42e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   2 NILNKILLQKKIEVgALLEQPDPLANFTE-----TPRRSLFESLCQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYA 76
Cdd:COG0134    2 TILDKIVAHKREEV-AARKARVPLAELEAraaaaPPPRDFAAALRAAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  77 LAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLG 156
Cdd:COG0134   81 AGGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 157 LEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDDAKLVASMGASGVL 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIP--ADVLVVSESGIRTPEDVARLAAAGADAFL 238

                        250
                 ....*....|....*...
gi 490346731 237 VGEALMRSGDAGQALRDL 254
Cdd:COG0134  239 VGEALMRAPDPGAALREL 256
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-254 4.35e-119

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 340.60  E-value: 4.35e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   1 MNILNKILLQKKIEVgALLEQPDPLANFTE-----TPRRSLFESLCQAQtLQVIAEMKRASPSKGLIAGGADPVAQAKVY 75
Cdd:PRK00278   2 MDILDKIVAYKREEV-AARKAQVPLAELKAraaaaPPPRDFAAALRAGK-PAVIAEVKKASPSKGVIREDFDPVEIAKAY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  76 ALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGL 155
Cdd:PRK00278  80 EAGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 156 GLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDDAKLVASMGASGV 235
Cdd:PRK00278 160 GLDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIP--SDRLVVSESGIFTPEDLKRLAKAGADAV 237

                        250
                 ....*....|....*....
gi 490346731 236 LVGEALMRSGDAGQALRDL 254
Cdd:PRK00278 238 LVGESLMRADDPGAALREL 256
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 38-254 6.51e-110

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 315.94  E-value: 6.51e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  38 ESLCQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMI 117
Cdd:cd00331    3 AALKRPGGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDFII 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 118 DRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERT 197
Cdd:cd00331   83 DPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLNTT 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490346731 198 REIANVFPfdENRVLISESGIWTQDDAKLVASMGASGVLVGEALMRSGDAGQALRDL 254
Cdd:cd00331  163 ERLAPLIP--KDVILVSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALREL 217
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
4-253 2.14e-101

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 295.74  E-value: 2.14e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731    4 LNKILLQKKIEVGALLEQPdPLANFTET----PRRSLFESLCQ-AQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYALA 78
Cdd:pfam00218   1 LEKIVADKRAEVAARKARP-PLADLQAAarapPTRSFYDALREsRGRPALIAEVKKASPSKGLIREDFDPAEIARVYEAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   79 GAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLE 158
Cdd:pfam00218  80 GASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGME 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  159 VLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPFDenRVLISESGIWTQDDAKLVASMGASGVLVG 238
Cdd:pfam00218 160 VLVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPAD--VLLVAESGIYTPADVRELKEHGANAFLVG 237

                         250
                  ....*....|....*
gi 490346731  239 EALMRSGDAGQALRD 253
Cdd:pfam00218 238 ESLMRQEDVRAAIRE 252
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 2-254 3.24e-78

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 243.18  E-value: 3.24e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   2 NILNKILLQKKIEVGALlEQPDPLANFTE--TPR-RSLFESLCQAQTlQVIAEMKRASPSKGLIAGGADPVAQAKVYAlA 78
Cdd:PRK09427   5 TVLAKIVADKAIWVAAR-KQQQPLASFQNeiQPSdRSFYDALKGPKT-AFILECKKASPSKGLIRDDFDPAEIARVYK-H 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  79 GAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLE 158
Cdd:PRK09427  82 YASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 159 VLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDDAKLVASmGASGVLVG 238
Cdd:PRK09427 162 VLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIP--ADVIVISESGIYTHAQVRELSP-FANGFLIG 238

                        250
                 ....*....|....*.
gi 490346731 239 EALMRSGDAGQALRDL 254
Cdd:PRK09427 239 SSLMAEDDLELAVRKL 254
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 2-254 5.37e-60

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 193.07  E-value: 5.37e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   2 NILNKILLQKKIEVgALLEQPDPLANFTET-----PRRSLFESLCQAQTLQ----VIAEMKRASPSKGLIAGGADPVAQA 72
Cdd:PLN02460  67 NILEEIVWYKDVEV-AQMKERKPLYLLKKAlqnapPARDFVGALRAAHKRTgqpgLIAEVKKASPSRGVLRENFDPVEIA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  73 KVYALAGAAAISVLTDKEFFKGSFEDLAAVAGA-VDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSY 151
Cdd:PLN02460 146 QAYEKGGAACLSVLTDEKYFQGSFENLEAIRNAgVKCPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKI 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 152 ATGLGLEVLVEVHDCEELERALAVNA-KLIGVNNRDLRTFEVSLERTREIANVFPFDENR----VLISESGIWTQDDAKL 226
Cdd:PLN02460 226 CKSLGMAALIEVHDEREMDRVLGIEGvELIGINNRSLETFEVDISNTKKLLEGERGEQIRekgiIVVGESGLFTPDDVAY 305

                        250       260
                 ....*....|....*....|....*...
gi 490346731 227 VASMGASGVLVGEALMRSGDAGQALRDL 254
Cdd:PLN02460 306 VQNAGVKAVLVGESLVKQDDPGKGIAGL 333
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 3-254 7.32e-51

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 166.98  E-value: 7.32e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731   3 ILNKILLQKKIEVgalleqpDPLANFTETPRR--SLFESLcQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYALAGA 80
Cdd:PRK13957   4 VLREIIETKQNEI-------EKISRWDPLPDRglPLRDSL-KSRSFSIIAECKRKSPSAGELRADYHPVQIAKTYETLGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  81 AAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLEVL 160
Cdd:PRK13957  76 SAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMDVL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 161 VEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPfdENRVLISESGIWTQDD----AKLVASMgasgvL 236
Cdd:PRK13957 156 VEVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFLP--PNIVKVGESGIESRSDldkfRKLVDAA-----L 228

                        250
                 ....*....|....*...
gi 490346731 237 VGEALMRSGDAGQALRDL 254
Cdd:PRK13957 229 IGTYFMEKKDIRKAWLSL 246
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 40-254 1.86e-50

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 175.60  E-value: 1.86e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  40 LCQAQTLQVIAEMKRASPSKGLIAGGADPVAQAKVYALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDR 119
Cdd:PRK13802  44 LKRADGIPVIAEIKRASPSKGHLSDIPDPAALAREYEQGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTD 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 120 VQIRFAKAAGASIILLIVAALTDDALRDLYSYATGLGLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTRE 199
Cdd:PRK13802 124 YQIWEARAHGADLVLLIVAALDDAQLKHLLDLAHELGMTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNE 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490346731 200 IANVFPFDENRVliSESGIWTQDDAKLVASMGASGVLVGEALMRSGDAGQALRDL 254
Cdd:PRK13802 204 LAADLPDDVIKV--AESGVFGAVEVEDYARAGADAVLVGEGVATADDHELAVERL 256
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
48-254 1.17e-45

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 153.60  E-value: 1.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  48 VIAEMKRASPSkgliAGG---ADPVAQAKVYALAGAAAISVLTDKEFFKGSFEDLAAVAGAVDTPLLCKDFMIDRVQIrf 124
Cdd:NF041303  49 VIAEVKPTSPT----TDGtrdDDPVELAEAMVAGGAAALSVLTEPEHFGGSPETLRRVREAVDVPVLRKDFLLREAQL-- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 125 aKAAGASIILLIVAALTDDaLRDLYSYATGLGLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVF 204
Cdd:NF041303 123 -DAVEADVVLLIARFVGDD-LEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLAKLEVDLGTFESVAPHV 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 490346731 205 PfDENRVLISESGIWTQDDAKLVASMGASGVLVGEALMrSGDAGQALRDL 254
Cdd:NF041303 201 P-DDDVTLIAESGISTPADVRRMREAGADALLVGSAIM-DGDVRENTRRL 248
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 64-238 2.89e-05

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 43.73  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731  64 GGADPVAQAKVYALAGAAAISVLTDKEFFKGSFED----LAAVAGAVDTPLLCKDFMIDRVQI-----RFAKAAGASIIL 134
Cdd:cd04722   10 PSGDPVELAKAAAEAGADAIIVGTRSSDPEEAETDdkevLKEVAAETDLPLGVQLAINDAAAAvdiaaAAARAAGADGVE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490346731 135 LIVAA-----LTDDALRDLYSYATGLGLEVLVEVHDCEELERALAVNAKLIGVNNRDLRTFEVSLERTREIANVFPFDEN 209
Cdd:cd04722   90 IHGAVgylarEDLELIRELREAVPDVKVVVKLSPTGELAAAAAEEAGVDEVGLGNGGGGGGGRDAVPIADLLLILAKRGS 169

                        170       180       190
                 ....*....|....*....|....*....|
gi 490346731 210 RV-LISESGIWTQDDAKLVASMGASGVLVG 238
Cdd:cd04722  170 KVpVIAGGGINDPEDAAEALALGADGVIVG 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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