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Conserved domains on  [gi|490365288|ref|WP_004244952|]
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MULTISPECIES: class II fructose-bisphosphate aldolase [Proteus]

Protein Classification

class II fructose-bisphosphate aldolase( domain architecture ID 10013149)

class II fructose-1,6-bisphosphate (FBP) aldolase catalyzes the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate

EC:  4.1.2.13
Gene Ontology:  GO:0008270|GO:0004332|GO:0016832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 10-359 0e+00

fructose-bisphosphate aldolase; Provisional


:

Pssm-ID: 236406  Cd Length: 350  Bit Score: 746.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  10 PGVITGDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApQQAAILGAIS 89
Cdd:PRK09197   1 PGVATGEDYQEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIAGKGVKDDG-QGAAVLGAIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  90 GAHHVHQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKID 169
Cdd:PRK09197  80 GAKHVHEVAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAAGGKPLFSSHMIDLSEEPLEENIEICSKYLERMAKAG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 170 MTLEIELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYV 249
Cdd:PRK09197 160 MTLEIELGVTGGEEDGVDNSHEDNSKLYTQPEDVLYAYEALGKISGRFTIAASFGNVHGVYKPGNVKLRPEILKDSQEYV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 250 SEKYNLPHNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGADKPNKKYY 329
Cdd:PRK09197 240 SKKFGLPAKPFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDYYFKNYDYLQGQVGNPEGEDKPNKKYY 319

                        330       340       350
                 ....*....|....*....|....*....|
gi 490365288 330 DPRNWLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:PRK09197 320 DPRVWLRAAEASMAARLEEAFEDLNSIGVL 349
 
Name Accession Description Interval E-value
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 10-359 0e+00

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 746.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  10 PGVITGDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApQQAAILGAIS 89
Cdd:PRK09197   1 PGVATGEDYQEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIAGKGVKDDG-QGAAVLGAIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  90 GAHHVHQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKID 169
Cdd:PRK09197  80 GAKHVHEVAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAAGGKPLFSSHMIDLSEEPLEENIEICSKYLERMAKAG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 170 MTLEIELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYV 249
Cdd:PRK09197 160 MTLEIELGVTGGEEDGVDNSHEDNSKLYTQPEDVLYAYEALGKISGRFTIAASFGNVHGVYKPGNVKLRPEILKDSQEYV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 250 SEKYNLPHNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGADKPNKKYY 329
Cdd:PRK09197 240 SKKFGLPAKPFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDYYFKNYDYLQGQVGNPEGEDKPNKKYY 319

                        330       340       350
                 ....*....|....*....|....*....|
gi 490365288 330 DPRNWLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:PRK09197 320 DPRVWLRAAEASMAARLEEAFEDLNSIGVL 349
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 15-359 0e+00

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 647.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  15 GDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApQQAAILGAISGAHHV 94
Cdd:cd00946    1 GDDVLKLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYAGKGLKNEK-QKASIAGAIAAAHHV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  95 HQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEI 174
Cdd:cd00946   80 RSMAEHYGVPVVLHTDHCAKKLLPWFDGLLEADEEYFKQHGEPLFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 175 ELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYVSEKYN 254
Cdd:cd00946  160 EIGITGGEEDGVDNSGVDNAELYTQPEDVWYVYEALSKISPNFSIAAAFGNVHGVYKPGNVKLQPEILGEHQDYVREKLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 255 L-PHNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGADKPNKKYYDPRN 333
Cdd:cd00946  240 LaDDKPLYFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKNEDYLQGQIGNPEGPDKPNKKYYDPRV 319

                        330       340
                 ....*....|....*....|....*.
gi 490365288 334 WLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:cd00946  320 WLREGEKSMVARVKKAFEDLNSVNKL 345
FruBisAldo_II_A TIGR01520
fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Members of this family are ...
 4-359 0e+00

fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Members of this family are class II examples of the glycolytic enzyme fructose-bisphosphate aldolase (FBA). This model represents one of two deeply split, architecturally distinct clades of the family that includes class II fructose-bisphosphate aldolases, tagatose-bisphosphate aldolases, and related uncharacterized proteins. This family is well-conserved and includes characterized FBA from Saccharomyces cerevisiae, Escherichia coli, and Corynebacterium glutamicum. Proteins outside the scope of this model may also be designated as class II fructose-bisphosphate aldolases, but are well separated in an alignment-based phylogenetic tree. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130583  Cd Length: 357  Bit Score: 640.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288    4 VFDFVKPGVITGDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEAPQQAA 83
Cdd:TIGR01520   1 IFDFVKPGVITGDDVHKLFQYAKENNFAIPAINCTSSSTINAALEAAADVKSPIIIQFSNGGAAFIAGKGVKDEVPQGAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   84 ILGAISGAHHVHQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLA 163
Cdd:TIGR01520  81 ILGAIAGAHHVHSIAEHYGVPVVLHTDHCAKKLLPWVDGLLEAGEKYFSAHGKPLFSSHMIDLSEEPIEENIEICVKYLK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  164 RMAKIDMTLEIELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILR 243
Cdd:TIGR01520 161 RMAKIKMWLEIEIGITGGEEDGVDNSHMDAEALYTQPEDVYYAYEELSKISPNFSIAAAFGNVHGVYKPGNVKLTPDILA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  244 NSQDYVSEKYNLP-HNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGAD 322
Cdd:TIGR01520 241 DGQEYVSEKLGLPaAKPLFFVFHGGSGSTKQEIKEALSYGVVKMNIDTDTQWAYWEGILNYYKNNEDYLQGQLGNPKGPD 320

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 490365288  323 KPNKKYYDPRNWLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:TIGR01520 321 KPNKKFYDPRVWLREGEKSMKARVEKACQELNNINVL 357
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 17-357 1.92e-120

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 349.00  E-value: 1.92e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  17 DVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIagkglkaeapqqaailGAISGAHHVHQ 96
Cdd:COG0191    4 SLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYA----------------GLEYLAAMVRA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  97 MAEYYGVPVILHTDHCAkkllpwidglldaGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIEL 176
Cdd:COG0191   68 AAEEASVPVALHLDHGA-------------SFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAEL 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 177 GCTGGEEDGVDNTgmDSSALYTQPEDVAYAYEKlnaiSPRFTIAASFGNVHGVYKpGNVQLTPKILRNSQDYVsekynlp 256
Cdd:COG0191  135 GVVGGEEDGVDVD--DAEALYTDPEEAAEFVEE----TGVDALAVAIGTVHGVYK-GEPKLDFDRLKEIREAV------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 257 hnSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNegylqsqlgnpegadkPNKkyYDPRNWLR 336
Cdd:COG0191  201 --PVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTAAVREYLAEN----------------PDK--YDPRKYLK 260

                        330       340
                 ....*....|....*....|.
gi 490365288 337 HGQTSMVVRLEQAFKELNAID 357
Cdd:COG0191  261 PAREAMKEVVKEKIRLFGSAG 281
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
16-357 2.94e-116

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 338.23  E-value: 2.94e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   16 DDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGkglkaeapqqaailGAISGAHHVH 95
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAG--------------GAEALAALVR 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   96 QMAEYYGVPVILHTDHCAKkllpwIDGLLDAGEKhyaktgkpLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIE 175
Cdd:pfam01116  67 AAAEAAGVPVALHLDHGAS-----FELIKEAIEA--------GFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAE 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  176 LGCTGGEEDGVdntgMDSSALYTQPEDVAYAYEKLNaispRFTIAASFGNVHGVYKPGNvQLTPKILRNSQDYVsekynl 255
Cdd:pfam01116 134 LGRIGGEEDGV----VVDEKLYTDPEEAAEFVEATG----VDALAVAIGNVHGVYKPGP-KLDFDRLKEIQEAV------ 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  256 phnSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFykknegylqsqlgnpegadkpnKKYYDPRNWL 335
Cdd:pfam01116 199 ---PVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAVREY----------------------PPNKDPRKYL 253

                         330       340
                  ....*....|....*....|..
gi 490365288  336 RHGQTSMVVRLEQAFKELNAID 357
Cdd:pfam01116 254 RPAEEAMKEVVKEKIRLFGSAG 275
 
Name Accession Description Interval E-value
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 10-359 0e+00

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 746.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  10 PGVITGDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApQQAAILGAIS 89
Cdd:PRK09197   1 PGVATGEDYQEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIAGKGVKDDG-QGAAVLGAIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  90 GAHHVHQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKID 169
Cdd:PRK09197  80 GAKHVHEVAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAAGGKPLFSSHMIDLSEEPLEENIEICSKYLERMAKAG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 170 MTLEIELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYV 249
Cdd:PRK09197 160 MTLEIELGVTGGEEDGVDNSHEDNSKLYTQPEDVLYAYEALGKISGRFTIAASFGNVHGVYKPGNVKLRPEILKDSQEYV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 250 SEKYNLPHNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGADKPNKKYY 329
Cdd:PRK09197 240 SKKFGLPAKPFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDYYFKNYDYLQGQVGNPEGEDKPNKKYY 319

                        330       340       350
                 ....*....|....*....|....*....|
gi 490365288 330 DPRNWLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:PRK09197 320 DPRVWLRAAEASMAARLEEAFEDLNSIGVL 349
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 15-359 0e+00

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 647.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  15 GDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApQQAAILGAISGAHHV 94
Cdd:cd00946    1 GDDVLKLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYAGKGLKNEK-QKASIAGAIAAAHHV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  95 HQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEI 174
Cdd:cd00946   80 RSMAEHYGVPVVLHTDHCAKKLLPWFDGLLEADEEYFKQHGEPLFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 175 ELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYVSEKYN 254
Cdd:cd00946  160 EIGITGGEEDGVDNSGVDNAELYTQPEDVWYVYEALSKISPNFSIAAAFGNVHGVYKPGNVKLQPEILGEHQDYVREKLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 255 L-PHNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGADKPNKKYYDPRN 333
Cdd:cd00946  240 LaDDKPLYFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKNEDYLQGQIGNPEGPDKPNKKYYDPRV 319

                        330       340
                 ....*....|....*....|....*.
gi 490365288 334 WLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:cd00946  320 WLREGEKSMVARVKKAFEDLNSVNKL 345
FruBisAldo_II_A TIGR01520
fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Members of this family are ...
 4-359 0e+00

fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Members of this family are class II examples of the glycolytic enzyme fructose-bisphosphate aldolase (FBA). This model represents one of two deeply split, architecturally distinct clades of the family that includes class II fructose-bisphosphate aldolases, tagatose-bisphosphate aldolases, and related uncharacterized proteins. This family is well-conserved and includes characterized FBA from Saccharomyces cerevisiae, Escherichia coli, and Corynebacterium glutamicum. Proteins outside the scope of this model may also be designated as class II fructose-bisphosphate aldolases, but are well separated in an alignment-based phylogenetic tree. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130583  Cd Length: 357  Bit Score: 640.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288    4 VFDFVKPGVITGDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEAPQQAA 83
Cdd:TIGR01520   1 IFDFVKPGVITGDDVHKLFQYAKENNFAIPAINCTSSSTINAALEAAADVKSPIIIQFSNGGAAFIAGKGVKDEVPQGAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   84 ILGAISGAHHVHQMAEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLA 163
Cdd:TIGR01520  81 ILGAIAGAHHVHSIAEHYGVPVVLHTDHCAKKLLPWVDGLLEAGEKYFSAHGKPLFSSHMIDLSEEPIEENIEICVKYLK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  164 RMAKIDMTLEIELGCTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILR 243
Cdd:TIGR01520 161 RMAKIKMWLEIEIGITGGEEDGVDNSHMDAEALYTQPEDVYYAYEELSKISPNFSIAAAFGNVHGVYKPGNVKLTPDILA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  244 NSQDYVSEKYNLP-HNSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGAD 322
Cdd:TIGR01520 241 DGQEYVSEKLGLPaAKPLFFVFHGGSGSTKQEIKEALSYGVVKMNIDTDTQWAYWEGILNYYKNNEDYLQGQLGNPKGPD 320

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 490365288  323 KPNKKYYDPRNWLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:TIGR01520 321 KPNKKFYDPRVWLREGEKSMKARVEKACQELNNINVL 357
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 18-357 0e+00

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 550.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  18 VQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEAPQQAAILGAISGAHHVHQM 97
Cdd:cd00453    1 VQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISGAHHVHQM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  98 AEYYGVPVILHTDHCAKKLLPWIDGLLDAGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELG 177
Cdd:cd00453   81 AEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 178 CTGGEEDGVDNTGMDSSALYTQPEDVAYAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYVSEKYNLPH 257
Cdd:cd00453  161 CTGGEEDGVDNSHMDASALYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKKGNVVLTPTILRDSQEYVSKKHNLPH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 258 NSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGYLQSQLGNPEGADKPNKKYYDPRNWLRH 337
Cdd:cd00453  241 NSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLQGQLGNPKGEDQPNKKYYDPRVWLRA 320

                        330       340
                 ....*....|....*....|
gi 490365288 338 GQTSMVVRLEQAFKELNAID 357
Cdd:cd00453  321 GQTSMIARLEKAFQELNAID 340
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 13-359 2.60e-140

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 399.77  E-value: 2.60e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   13 ITGDDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGkglkaeapqqaaiLGAISGAH 92
Cdd:TIGR00167   1 MMLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAG-------------LGAISAMV 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   93 HVHQMAEYYGVPVILHTDHCAkkllpwidglldaGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTL 172
Cdd:TIGR00167  68 KAMSEAYPYGVPVALHLDHGA-------------SEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSV 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  173 EIELGCTGGEEDGVDntGMDSSALYTQPEdvayAYEKLNAISPRFTIAASFGNVHGVYKPGNVQLTPKILRNSQDYVsek 252
Cdd:TIGR00167 135 EAELGTLGGEEDGVS--VADESALYTDPE----EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKGLDFERLEEIQKYV--- 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  253 ynlphnSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKnegylqsqlgnpegadkpNKKYYDPR 332
Cdd:TIGR00167 206 ------NLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQIAFAAAVRNYYAE------------------NKDYYDPR 261

                         330       340
                  ....*....|....*....|....*..
gi 490365288  333 NWLRHGQTSMVVRLEQAFKELNAIDVL 359
Cdd:TIGR00167 262 VWLRPGEKAMKEVVLEKIKLFGSANKA 288
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 17-357 1.92e-120

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 349.00  E-value: 1.92e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  17 DVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIagkglkaeapqqaailGAISGAHHVHQ 96
Cdd:COG0191    4 SLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYA----------------GLEYLAAMVRA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  97 MAEYYGVPVILHTDHCAkkllpwidglldaGEKHYAKTGKPLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIEL 176
Cdd:COG0191   68 AAEEASVPVALHLDHGA-------------SFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAEL 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 177 GCTGGEEDGVDNTgmDSSALYTQPEDVAYAYEKlnaiSPRFTIAASFGNVHGVYKpGNVQLTPKILRNSQDYVsekynlp 256
Cdd:COG0191  135 GVVGGEEDGVDVD--DAEALYTDPEEAAEFVEE----TGVDALAVAIGTVHGVYK-GEPKLDFDRLKEIREAV------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 257 hnSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNegylqsqlgnpegadkPNKkyYDPRNWLR 336
Cdd:COG0191  201 --PVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTAAVREYLAEN----------------PDK--YDPRKYLK 260

                        330       340
                 ....*....|....*....|.
gi 490365288 337 HGQTSMVVRLEQAFKELNAID 357
Cdd:COG0191  261 PAREAMKEVVKEKIRLFGSAG 281
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
16-357 2.94e-116

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 338.23  E-value: 2.94e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   16 DDVQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGkglkaeapqqaailGAISGAHHVH 95
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAG--------------GAEALAALVR 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   96 QMAEYYGVPVILHTDHCAKkllpwIDGLLDAGEKhyaktgkpLFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIE 175
Cdd:pfam01116  67 AAAEAAGVPVALHLDHGAS-----FELIKEAIEA--------GFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAE 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  176 LGCTGGEEDGVdntgMDSSALYTQPEDVAYAYEKLNaispRFTIAASFGNVHGVYKPGNvQLTPKILRNSQDYVsekynl 255
Cdd:pfam01116 134 LGRIGGEEDGV----VVDEKLYTDPEEAAEFVEATG----VDALAVAIGNVHGVYKPGP-KLDFDRLKEIQEAV------ 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  256 phnSLNFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFykknegylqsqlgnpegadkpnKKYYDPRNWL 335
Cdd:pfam01116 199 ---PVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAVREY----------------------PPNKDPRKYL 253

                         330       340
                  ....*....|....*....|..
gi 490365288  336 RHGQTSMVVRLEQAFKELNAID 357
Cdd:pfam01116 254 RPAEEAMKEVVKEKIRLFGSAG 275
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 21-335 3.20e-51

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 171.56  E-value: 3.20e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  21 VFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIagkglkaeapqqaailGAISGAHHVHQMAEY 100
Cdd:cd00947    4 LLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYA----------------GLELLVAMVKAAAER 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 101 YGVPVILHTDHCAKkllpwIDGLLDAgekhyAKTGkplFSSHMIDLSEESLEENIEIcSKYLARMAK-IDMTLEIELGCT 179
Cdd:cd00947   68 ASVPVALHLDHGSS-----FELIKRA-----IRAG---FSSVMIDGSHLPFEENVAK-TKEVVELAHaYGVSVEAELGRI 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 180 GGEEDGVdntgMDSSALYTQPEDVAyayeklnaispRF-------TIAASFGNVHGVYKPGNVQLTPKILRNsqdyVSEK 252
Cdd:cd00947  134 GGEEDGV----VGDEGLLTDPEEAE-----------EFveetgvdALAVAIGTSHGAYKGGEPKLDFDRLKE----IAER 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 253 YNLPhnslnFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKnegylqsqlgnpegadkpNKKYYDPR 332
Cdd:cd00947  195 VNVP-----LVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALREYLAE------------------NPKEFDPR 251


                 ...
gi 490365288 333 NWL 335
Cdd:cd00947  252 KYL 254
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 20-354 1.36e-42

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 149.43  E-value: 1.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   20 KVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApqqaailgaisgahhVHQMAE 99
Cdd:TIGR01859   6 EILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGYKMAVAM---------------VKTLIE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  100 YYG-VPVILHTDH------CAKKLlpwidgllDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTL 172
Cdd:TIGR01859  71 RMSiVPVALHLDHgssyesCIKAI--------KAG-----------FSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSV 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  173 EIELGCTGGEEDGVDNTGmdssALYTQPEDVAYAYEKLNAISprftIAASFGNVHGVYkPGNVQLTPKILRNsqdyVSEK 252
Cdd:TIGR01859 132 EAELGTLGGIEDGVDEKE----AELADPDEAEQFVKETGVDY----LAAAIGTSHGKY-KGEPGLDFERLKE----IKEL 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  253 YNLPhnslnFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKnegylqsqlgnpegadkpNKKYYDPR 332
Cdd:TIGR01859 199 TNIP-----LVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTAAIRKVLTE------------------KKDEYDPR 255

                         330       340
                  ....*....|....*....|..
gi 490365288  333 NWLRHGQTSMVVRLEQAFKELN 354
Cdd:TIGR01859 256 KILGPAREAIKETVKEKMRLFG 277
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
18-308 7.85e-33

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 123.68  E-value: 7.85e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  18 VQKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFiAGkglkaeapqqaaiLGAISGAhhVHQM 97
Cdd:PRK12857   6 VAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKY-AG-------------IEYISAM--VRTA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  98 AEYYGVPVILHTDHCAKklLPWIDGLLDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELG 177
Cdd:PRK12857  70 AEKASVPVALHLDHGTD--FEQVMKCIRNG-----------FTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELG 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 178 CTGGEEDgvDNTGMDSSALYTQPEDVAYAYEKLNAISprftIAASFGNVHGVYKpgnvqLTPKILRNSQDYVSEKYNLPh 257
Cdd:PRK12857 137 KIGGTED--DITVDEREAAMTDPEEARRFVEETGVDA----LAIAIGTAHGPYK-----GEPKLDFDRLAKIKELVNIP- 204

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490365288 258 nslnFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNE 308
Cdd:PRK12857 205 ----IVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFVARLREVLEKNP 251
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 25-345 2.41e-31

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 119.85  E-value: 2.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFiAGKGLkaeapqqaaiLGAIsgahhVHQMAEYYGVP 104
Cdd:PRK09195  13 AQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSY-AGTEY----------LLAI-----VSAAAKQYHHP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDHCAKklLPWIDGLLDAGEKhyaktgkplfsSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGCTGGEED 184
Cdd:PRK09195  77 LALHLDHHEK--FDDIAQKVRSGVR-----------SVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQED 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 185 GVDNTGMDssALYTQPEDVAYAYEKLNAISprftIAASFGNVHGVYKpGNVQLTPKILRNsqdyVSEKYNLPhnslnFVF 264
Cdd:PRK09195 144 DLQVDEAD--ALYTDPAQAREFVEATGIDS----LAVAIGTAHGMYK-GEPKLDFDRLEN----IRQWVNIP-----LVL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 265 HGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQfykknegYLQSqlgNPEGAdkpnkkyyDPRNWLRHGQTSM-- 342
Cdd:PRK09195 208 HGASGLPTKDIQQTIKLGICKVNVATELKIAFSQALKN-------YLTE---HPEAN--------DPRHYLQPAKSAMkd 269


                 ...
gi 490365288 343 VVR 345
Cdd:PRK09195 270 VVS 272
PRK08185 PRK08185
hypothetical protein; Provisional
 23-333 2.51e-31

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 119.45  E-value: 2.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  23 AVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSnggaafiagkglkaeaPQQAAILGAISGAHhVHQMAEYYG 102
Cdd:PRK08185   6 KVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIH----------------PNELDFLGDNFFAY-VRERAKRSP 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 103 VPVILHTDHCAKKllpwidglldageKHYAKTGKPLFSSHMIDLSEESLEENIEIcSKYLARMA-KIDMTLEIELGCTGG 181
Cdd:PRK08185  69 VPFVIHLDHGATI-------------EDVMRAIRCGFTSVMIDGSLLPYEENVAL-TKEVVELAhKVGVSVEGELGTIGN 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 182 EEDGVDntGMDSSALYTQPEDvAYAYEKLNAISprfTIAASFGNVHGVYKPGnvqLTPKILRNSQDYVSEKYNLPhnsln 261
Cdd:PRK08185 135 TGTSIE--GGVSEIIYTDPEQ-AEDFVSRTGVD---TLAVAIGTAHGIYPKD---KKPELQMDLLKEINERVDIP----- 200

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490365288 262 FVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWAtwdgilqFYKKNEGYLQSqlgNPEGADkPNKKYYDPRN 333
Cdd:PRK08185 201 LVLHGGSANPDAEIAESVQLGVGKINISSDMKYA-------FFKKVREILSD---NPSLYE-PNQIYPSAIE 261
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 25-335 4.31e-30

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 116.24  E-value: 4.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKglkaeapqqAAILGAISGAHHVHQMAeyygVP 104
Cdd:PRK08610  13 AKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSGF---------YTVVKMVEGLMHDLNIT----IP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDH------CAKKLlpwidgllDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGC 178
Cdd:PRK08610  80 VAIHLDHgssfekCKEAI--------DAG-----------FTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGT 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 179 TGGEEDGVDNTGMdssaLYTQPEDVAYAYEKlNAISprfTIAASFGNVHGVYKPgnvqlTPKILRNSQDYVSEKYNLPhn 258
Cdd:PRK08610 141 VGGQEDDVVADGI----IYADPKECQELVEK-TGID---ALAPALGSVHGPYKG-----EPKLGFKEMEEIGLSTGLP-- 205

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490365288 259 slnFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGIlqfykknegylQSQLGNpegadkpNKKYYDPRNWL 335
Cdd:PRK08610 206 ---LVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASAKAV-----------RDVLNN-------DKEVYDPRKYL 261
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
25-345 3.15e-29

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 114.02  E-value: 3.15e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQ-----FSNGGAAFIAgkglkaeapqqaailgAISGahhvhQMAE 99
Cdd:PRK12737  13 AQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAgtpgtFSYAGTDYIV----------------AIAE-----VAAR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 100 YYGVPVILHTDHcaKKLLPWIDGLLDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGCT 179
Cdd:PRK12737  72 KYNIPLALHLDH--HEDLDDIKKKVRAG-----------IRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRL 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 180 GGEEDgvDNTGMDSSALYTQPEDvAYAYEKLNAISprfTIAASFGNVHGVYKPgnvqlTPKILRNSQDYVSEKYNLPhns 259
Cdd:PRK12737 139 GGQED--DLVVDEKDAMYTNPDA-AAEFVERTGID---SLAVAIGTAHGLYKG-----EPKLDFERLAEIREKVSIP--- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 260 lnFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKnegylqsqlgNPEGAdkpnkkyyDPRNWLRHGQ 339
Cdd:PRK12737 205 --LVLHGASGVPDEDVKKAISLGICKVNVATELKIAFSDAVKKYFYE----------NPKAN--------DPRKYMTPGK 264


                 ....*...
gi 490365288 340 TSM--VVR 345
Cdd:PRK12737 265 AAMkeVVR 272
PRK06806 PRK06806
class II aldolase;
25-310 9.27e-25

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 101.76  E-value: 9.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQfsnggaafIAGKGLKaEAPQQaaILGAIsgahhVHQMAEYYGVP 104
Cdd:PRK06806  13 ANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQ--------IAEVRLN-HSPLH--LIGPL-----MVAAAKQAKVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDHcaKKLLPWIDGLLDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGCTGGEED 184
Cdd:PRK06806  77 VAVHFDH--GMTFEKIKEALEIG-----------FTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSED 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 185 GVDNTGMdssaLYTQPEDVAYAYEKLNAISprftIAASFGNVHGVYKpGNVQLTPKILRNsqdyVSEKYNLPhnslnFVF 264
Cdd:PRK06806 144 GSEDIEM----LLTSTTEAKRFAEETDVDA----LAVAIGNAHGMYN-GDPNLRFDRLQE----INDVVHIP-----LVL 205

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 490365288 265 HGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEGY 310
Cdd:PRK06806 206 HGGSGISPEDFKKCIQHGIRKINVATATFNSVITAVNNLVLNTPYS 251
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 25-342 5.51e-24

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 99.74  E-value: 5.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGkgLKAEAPQQAAILGAISgahhvhqmaeyYGVP 104
Cdd:PRK07709  13 ALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTG--FKTVVAMVKALIEEMN-----------ITVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDHCAKklLPWIDGLLDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGCTGGEED 184
Cdd:PRK07709  80 VAIHLDHGSS--FEKCKEAIDAG-----------FTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQED 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 185 GVDNTGMdssaLYTQPEDVAYAYEK--LNAISPrftiaaSFGNVHGVYKPgnvqlTPKILRNSQDYVSEKYNLPhnslnF 262
Cdd:PRK07709 147 DVIAEGV----IYADPAECKHLVEAtgIDCLAP------ALGSVHGPYKG-----EPNLGFAEMEQVRDFTGVP-----L 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 263 VFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKNEgylqsqlgnpegadkpnkKYYDPRNWLRHGQTSM 342
Cdd:PRK07709 207 VLHGGTGIPTADIEKAISLGTSKINVNTENQIEFTKAVREVLNKDQ------------------EVYDPRKFIGPGRDAI 268
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
19-359 1.40e-23

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 99.42  E-value: 1.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  19 QKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKAEApqQAAIlgaisgahhvhQMA 98
Cdd:PRK07084  13 REMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANATLLRYMA--QGAV-----------EYA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  99 EYYG--VPVILHTDHCakkllpwidgllDAGE--KHYAKTGkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEI 174
Cdd:PRK07084  80 KELGcpIPIVLHLDHG------------DSFElcKDCIDSG---FSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 175 ELGCTGGEEDGVDNTgmdsSALYTQPEDVAYAYEKLNAISprftIAASFGNVHGVYK--PGnvQLTPKILRNSQDYVSEK 252
Cdd:PRK07084 145 ELGVLAGVEDEVSAE----HHTYTQPEEVEDFVKKTGVDS----LAISIGTSHGAYKfkPG--QCPPPLRFDILEEIEKR 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 253 ynLPhnSLNFVFHGGS---------------------GSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYkknegyl 311
Cdd:PRK07084 215 --IP--GFPIVLHGSSsvpqeyvktineyggklkdaiGIPEEQLRKAAKSAVCKINIDSDGRLAMTAAIRKVF------- 283

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 490365288 312 qsqlgnpegADKPnkKYYDPRNWLRHGQTSMvvrlEQAFKELNaIDVL 359
Cdd:PRK07084 284 ---------DEKP--EEFDPRKYLGPARDEL----KKLYKHKI-INVL 315
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
25-345 5.37e-23

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 97.03  E-value: 5.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLKaeapqqaailgAISGAHhvhqmAEYYGVP 104
Cdd:PRK12738  13 AQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIY-----------ALCSAY-----STTYNMP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDHcaKKLLPWIDGLLDAGEKhyaktgkplfsSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGCTGGEED 184
Cdd:PRK12738  77 LALHLDH--HESLDDIRRKVHAGVR-----------SAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVED 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 185 GVDntgMDS-SALYTQPEDvAYAYEKLNAISprfTIAASFGNVHGVYKPgnvqlTPKILRNSQDYVSEKYNLPhnslnFV 263
Cdd:PRK12738 144 DMS---VDAeSAFLTDPQE-AKRFVELTGVD---SLAVAIGTAHGLYSK-----TPKIDFQRLAEIREVVDVP-----LV 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 264 FHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKnegylqsqlgNPEGAdkpnkkyyDPRNWLRHGQTSM- 342
Cdd:PRK12738 207 LHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAE----------NPQGN--------DPRYYMRVGMDAMk 268


                 ....
gi 490365288 343 -VVR 345
Cdd:PRK12738 269 eVVR 272
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
25-348 1.10e-22

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 97.33  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNG-----GAAFIAgkglkaeapqqAAILGAIsgahhvhqmAE 99
Cdd:PRK09196  13 AAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGarkyaGEPFLR-----------HLILAAV---------EE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 100 YYGVPVILHTDH------CAkkllpwidGLLDAGekhyaktgkplFSSHMIDLSEE-------SLEENIEICSKyLARMA 166
Cdd:PRK09196  73 YPHIPVVMHQDHgnspatCQ--------RAIQLG-----------FTSVMMDGSLKadgktpaSYEYNVDVTRK-VVEMA 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 167 -KIDMTLEIELGC-------TGGEEDGVDNTG-MDSSALYTQPEDVA--YAYEKLNAIsprftiAASFGNVHGVYK---- 231
Cdd:PRK09196 133 hACGVSVEGELGClgsletgMGGEEDGHGAEGkLSHDQLLTDPEEAAdfVKKTQVDAL------AIAIGTSHGAYKftrk 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 232 PgnvqlTPKILRnsQDYVSEKYN-LPHNSLnfVFHGGS---------------------GSSAEEIKEAVSYGVVKMNID 289
Cdd:PRK09196 207 P-----TGDVLA--IDRIKEIHArLPNTHL--VMHGSSsvpqelldiineyggdmpetyGVPVEEIQEGIKHGVRKVNID 277

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490365288 290 TDTQWATWDGILQFYKKnegylqsqlgnpegadkpNKKYYDPRNWLRHGQTSM----VVRLEQ 348
Cdd:PRK09196 278 TDLRLAMTGAIRRFLAE------------------NPSEFDPRKYLKPAMEAMkkicKARYEA 322
gatY PRK07998
class II aldolase;
25-307 1.97e-22

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 95.21  E-value: 1.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQfsnggaafIAGKGLKAEAPQqaaILGAIsgahhVHQMAEYYGVP 104
Cdd:PRK07998  13 IQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQ--------IAPTNAQLSGYD---YIYEI-----VKRHADKMDVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDHcaKKLLPWIDGLLDAGekhyaktgkplFSSHMIDLSEESLEENIEIcSKYLARMAKI-DMTLEIELGCTGGEE 183
Cdd:PRK07998  77 VSLHLDH--GKTFEDVKQAVRAG-----------FTSVMIDGAALPFEENIAF-TKEAVDFAKSyGVPVEAELGAILGKE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 184 DGvDNTGMDSsalYTQPEDVAYAYEKLNAIsprfTIAASFGNVHGvykpgnVQLTPKILRNSQDYVSEKYNLPhnslnFV 263
Cdd:PRK07998 143 DD-HVSEADC---KTEPEKVKDFVERTGCD----MLAVSIGNVHG------LEDIPRIDIPLLKRIAEVSPVP-----LV 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 490365288 264 FHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYKKN 307
Cdd:PRK07998 204 IHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFITTVGKAYVNN 247
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
23-290 1.39e-20

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 90.20  E-value: 1.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  23 AVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFsnggaafiagkglkAEAPQQAAILGAIsgAHHVHQMAEYYG 102
Cdd:PRK06801  11 AHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINI--------------AEVHFKYISLESL--VEAVKFEAARHD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 103 VPVILHTDHcakkllpwidGLLDAGEKHYAKTGkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELGCTGGE 182
Cdd:PRK06801  75 IPVVLNLDH----------GLHFEAVVRALRLG---FSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGD 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 183 EDGVDNTGMDSsALYTQPEdVAYAYEKLNAISprfTIAASFGNVHGVYKPgnvqlTPKILRNSQDYVSEKYNLPhnslnF 262
Cdd:PRK06801 142 EGGALYGEADS-AKFTDPQ-LARDFVDRTGID---ALAVAIGNAHGKYKG-----EPKLDFARLAAIHQQTGLP-----L 206

                        250       260
                 ....*....|....*....|....*...
gi 490365288 263 VFHGGSGSSAEEIKEAVSYGVVKMNIDT 290
Cdd:PRK06801 207 VLHGGSGISDADFRRAIELGIHKINFYT 234
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 19-348 4.66e-20

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 88.79  E-value: 4.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  19 QKVFAVAKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFIAGKGLkaeapqqAAILgaisgahhVHQMA 98
Cdd:PRK07315   7 EKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKV-------CKNL--------IENLV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  99 EYYG--VPVILHTDHCAkkllpwIDGLLDAGEKHYaktgkplfSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIEL 176
Cdd:PRK07315  72 ESMGitVPVAIHLDHGH------YEDALECIEVGY--------TSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEV 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 177 GCTGGEEDGVDNTGMdssalyTQPEDVAYAyekLNAISPRFtIAASFGNVHGVYKPGNVQLTPKILRNSQDYVSekyNLP 256
Cdd:PRK07315 138 GTIGGEEDGIIGKGE------LAPIEDAKA---MVETGIDF-LAAGIGNIHGPYPENWEGLDLDHLEKLTEAVP---GFP 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 257 hnslnFVFHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQF---YKKNEgylqsqlgnpegADKPNKKYYDPRN 333
Cdd:PRK07315 205 -----IVLHGGSGIPDDQIQEAIKLGVAKVNVNTECQIAFANATRKFardYEANE------------AEYDKKKLFDPRK 267

                        330
                 ....*....|....*
gi 490365288 334 WLRHGQTSMVVRLEQ 348
Cdd:PRK07315 268 FLAPGVKAIQASVEE 282
PLN02858 PLN02858
fructose-bisphosphate aldolase
 25-295 4.70e-18

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 85.67  E-value: 4.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288   25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGgaAFIAGkGLkaeaPQQAAILGAisgahhvhqmAEYYGVP 104
Cdd:PLN02858 1109 AEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPG--ALKQG-GI----PLVSCCIAA----------AEQASVP 1171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  105 VILHTDHCAKKllpwiDGLLDAGEKHyaktgkplFSSHMIDLSEESLEENIEIcSKYLARMAKI-DMTLEIELGCTGGEE 183
Cdd:PLN02858 1172 ITVHFDHGTSK-----HELLEALELG--------FDSVMVDGSHLSFTENISY-TKSISSLAHSkGLMVEAELGRLSGTE 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  184 DGVdnTGMDSSALYTqpeDVAYAYEKLNAISPRfTIAASFGNVHGVYKPGNVQLTPKILRNSQDYVSEKynlphnSLNFV 263
Cdd:PLN02858 1238 DGL--TVEEYEAKLT---DVDQAKEFIDETGID-ALAVCIGNVHGKYPASGPNLRLDLLKELRALSSKK------GVLLV 1305

                         250       260       270
                  ....*....|....*....|....*....|..
gi 490365288  264 FHGGSGSSAEEIKEAVSYGVVKMNIDTDTQWA 295
Cdd:PLN02858 1306 LHGASGLPESLIKECIENGVRKFNVNTEVRTA 1337
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
25-354 2.29e-16

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 79.05  E-value: 2.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFiAGkglkaEAPQQAAILGAISgahhvhqmaEYYGVP 104
Cdd:PRK13399  13 AAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKY-AG-----DAMLRHMVLAAAE---------MYPDIP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 105 VILHTDHcakkllpwidGLLDAGEKHYAKTGkplFSSHMIDLSEE-------SLEENIEIcSKYLARMAK-IDMTLEIEL 176
Cdd:PRK13399  78 ICLHQDH----------GNSPATCQSAIRSG---FTSVMMDGSLLadgktpaSYDYNVDV-TRRVTEMAHaVGVSVEGEL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 177 GC-------TGGEEDGVDNTG-MDSSALYTQPEDVAYAYEKLNAISprftIAASFGNVHGVYKPGNvQLTPKILrnSQDY 248
Cdd:PRK13399 144 GClgsletgEAGEEDGVGAEGkLSHDQMLTDPDQAVDFVQRTGVDA----LAIAIGTSHGAYKFTR-KPDGDIL--AIDR 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 249 VSEKY-NLPHNSLnfVFHGGS---------------------GSSAEEIKEAVSYGVVKMNIDTDTQWATWDGILQFYkk 306
Cdd:PRK13399 217 IEEIHaRLPNTHL--VMHGSSsvpqelqeiinayggkmketyGVPVEEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVL-- 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 490365288 307 negylqsqlgnpegADKPNKkyYDPRNWLRHGQTSMVVRLEQAFKELN 354
Cdd:PRK13399 293 --------------AEHPSE--FDPRKALKPAMKAMTALCKQRFEAFG 324
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
25-295 6.56e-15

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 74.24  E-value: 6.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288  25 AKENNFALPAVNCVGTDSINAVLEAAAKVRSPVIVQFSNGGAAFiagkglkaeapqqaaiLGAISGAHHVHQMAEYY-GV 103
Cdd:PRK05835  12 AHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKY----------------MGIDMAVGMVKIMCERYpHI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 104 PVILHTDH------CAKKLlpwidgllDAGekhyaktgkplFSSHMIDLSEESLEENIEICSKYLARMAKIDMTLEIELG 177
Cdd:PRK05835  76 PVALHLDHgttfesCEKAV--------KAG-----------FTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELG 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490365288 178 CTGGEEDGVDNTGMDssALYTQPEDvAYAYEKLNAISprfTIAASFGNVHGVYKpgnVQLTPKILRNSQDYVSEKYNLPh 257
Cdd:PRK05835 137 RLMGIEDNISVDEKD--AVLVNPKE-AEQFVKESQVD---YLAPAIGTSHGAFK---FKGEPKLDFERLQEVKRLTNIP- 206

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 490365288 258 nslnFVFHGGS---------------------GSSAEEIKEAVSYGVVKMNIDTDTQWA 295
Cdd:PRK05835 207 ----LVLHGASaipddvrksyldaggdlkgskGVPFEFLQESVKGGINKVNTDTDLRIA 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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